TreeWAS – Variant ID: rs114357381

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability
M20-M25 Other joint disorders	1.000	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	1.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000
# Top node	1.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000
M23 Internal derangement of knee	0.999	0.001
M25 Other joint disorders, not elsewhere classified	0.999	0.001
M23.2 Derangement of meniscus due to old tear or injury	0.999	0.001
M25.5 Pain in joint	0.994	0.006
Chapter V Mental and behavioural disorders	0.990	0.010
M05-M14 Inflammatory polyarthropathies	0.988	0.012
I20-I25 Ischaemic heart diseases	0.986	0.014
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)	0.986	0.014
I10-I15 Hypertensive diseases	0.984	0.016
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.984	0.016
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.983	0.017
M10 Gout	0.978	0.022
I10 Essential (primary) hypertension	0.973	0.027
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.972	0.028
M10.9 Gout, unspecified	0.970	0.030
S00-S09 Injuries to the head	0.966	0.034
Chapter XX External causes of morbidity and mortality	0.965	0.035
S60-S69 Injuries to the wrist and hand	0.964	0.036
M10.99 Gout, unspecified (Site unspecified)	0.962	0.038
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.960	0.040
I84 Haemorrhoids	0.960	0.040
M25.56 Pain in joint (Lower leg)	0.959	0.041
I84.6 Residual haemorrhoidal skin tags	0.958	0.042
Chapter XI Diseases of the digestive system	0.950	0.050
S64 Injury of nerves at wrist and hand level	0.941	0.059
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.937	0.063
F30-F39 Mood [affective] disorders	0.934	0.066
K65-K67 Diseases of peritoneum	0.931	0.069
M25.6 Stiffness of joint, not elsewhere classified	0.922	0.078
K66 Other disorders of peritoneum	0.922	0.078
S01 Open wound of head	0.921	0.079
S64.4 Injury of digital nerve of other finger	0.920	0.080
I24 Other acute ischaemic heart diseases	0.919	0.081
K66.0 Peritoneal adhesions	0.916	0.084
Y86 Sequelae of other accidents	0.915	0.085
K70-K77 Diseases of liver	0.914	0.086
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.914	0.086
M24 Other specific joint derangements	0.912	0.088
M25.55 Pain in joint (Pelvic region and thigh)	0.909	0.091
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.902	0.098
F17 Mental and behavioural disorders due to use of tobacco	0.902	0.098
S40-S49 Injuries to the shoulder and upper arm	0.897	0.103
F32 Depressive episode	0.895	0.105
M80-M85 Disorders of bone density and structure	0.893	0.107
I20 Angina pectoris	0.889	0.111
I24.9 Acute ischaemic heart disease, unspecified	0.881	0.119
Chapter VIII Diseases of the ear and mastoid process	0.880	0.120
S80-S89 Injuries to the knee and lower leg	0.875	0.125
T85 Complications of other internal prosthetic devices, implants and grafts	0.874	0.126
Chapter IV Endocrine, nutritional and metabolic diseases	0.873	0.127
F17.1 Harmful use	0.866	0.134
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.864	0.136
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.864	0.136
F10 Mental and behavioural disorders due to use of alcohol	0.862	0.138
I20.0 Unstable angina	0.860	0.140
E10-E14 Diabetes mellitus	0.858	0.142
T81 Complications of procedures, not elsewhere classified	0.856	0.144
I70-I79 Diseases of arteries, arterioles and capillaries	0.856	0.144
F32.9 Depressive episode, unspecified	0.852	0.148
I84.1 Internal haemorrhoids with other complications	0.852	0.148
I05-I09 Chronic rheumatic heart diseases	0.851	0.149
S01.0 Open wound of scalp	0.849	0.151
M13 Other arthritis	0.846	0.154
K86 Other diseases of pancreas	0.845	0.155
T66-T78 Other and unspecified effects of external causes	0.843	0.157
M23.3 Other meniscus derangements	0.833	0.167
M25.53 Pain in joint (Forearm)	0.832	0.168
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified	0.829	0.171
H60-H62 Diseases of external ear	0.828	0.172
S00 Superficial injury of head	0.827	0.173
T36-T50 Poisoning by drugs, medicaments and biological substances	0.825	0.175
T86 Failure and rejection of transplanted organs and tissues	0.825	0.175
S01.8 Open wound of other parts of head	0.825	0.175
M24.1 Other articular cartilage disorders	0.820	0.180
K82 Other diseases of gallbladder	0.819	0.181
M25.4 Effusion of joint	0.819	0.181
I25 Chronic ischaemic heart disease	0.818	0.182
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.818	0.182
S10-S19 Injuries to the neck	0.818	0.182
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.818	0.182
E10 Insulin-dependent diabetes mellitus	0.817	0.183
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)	0.814	0.186
Chapter XV Pregnancy, childbirth and the puerperium	0.812	0.188
I84.4 External haemorrhoids with other complications	0.804	0.196
M65-M68 Disorders of synovium and tendon	0.803	0.197
S42 Fracture of shoulder and upper arm	0.801	0.199
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.798	0.202
M84 Disorders of continuity of bone	0.796	0.204
M23.4 Loose body in knee	0.796	0.204
M25.8 Other specified joint disorders	0.794	0.206
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.792	0.208
I71 Aortic aneurysm and dissection	0.789	0.211
Z72.1 Alcohol use	0.789	0.211
M10.97 Gout, unspecified (Ankle and foot)	0.788	0.212
K70 Alcoholic liver disease	0.788	0.212
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)	0.786	0.214
M25.54 Pain in joint (Hand)	0.785	0.215
K72 Hepatic failure, not elsewhere classified	0.784	0.216
S60 Superficial injury of wrist and hand	0.783	0.217
M86-M90 Other osteopathies	0.783	0.217
W00-W19 Falls	0.783	0.217
K90-K93 Other diseases of the digestive system	0.782	0.218
M91-M94 Chondropathies	0.782	0.218
Chapter VI Diseases of the nervous system	0.781	0.219
K86.1 Other chronic pancreatitis	0.779	0.221
M45-M49 Spondylopathies	0.777	0.223
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.774	0.226
X60-X84 Intentional self-harm	0.774	0.226
M25.7 Osteophyte	0.773	0.227
S62 Fracture at wrist and hand level	0.773	0.227
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.772	0.228
M25.59 Pain in joint (Site unspecified)	0.768	0.231
Z72 Problems related to lifestyle	0.768	0.232
Chapter XXI Factors influencing health status and contact with health services	0.767	0.233
M22 Disorders of patella	0.767	0.233
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.767	0.233
Chapter XXII Codes for special purposes	0.766	0.234
M14 Arthropathies in other diseases classified elsewhere	0.766	0.234
Z70-Z76 Persons encountering health services in other circumstances	0.765	0.235
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.763	0.237
I22 Subsequent myocardial infarction	0.762	0.238
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.762	0.238
M25.50 Pain in joint (Multiple sites)	0.762	0.238
W50-W64 Exposure to animate mechanical forces	0.761	0.239
H61 Other disorders of external ear	0.756	0.244
M34 Systemic sclerosis	0.756	0.244
I86 Varicose veins of other sites	0.752	0.248
F10.1 Harmful use	0.752	0.248
K74 Fibrosis and cirrhosis of liver	0.752	0.248
K81 Cholecystitis	0.752	0.248
H90-H95 Other disorders of ear	0.752	0.248
Chapter I Certain infectious and parasitic diseases	0.749	0.251
S49 Other and unspecified injuries of shoulder and upper arm	0.749	0.251
T84.1 Mechanical complication of internal fixation device of bones of limb	0.749	0.251
I21 Acute myocardial infarction	0.745	0.255
O80-O84 Delivery	0.745	0.255
I85 Oesophageal varices	0.745	0.255
T79-T79 Certain early complications of trauma	0.744	0.256
S90-S99 Injuries to the ankle and foot	0.741	0.259
S20-S29 Injuries to the thorax	0.741	0.259
S64.2 Injury of radial nerve at wrist and hand level	0.741	0.259
I08 Multiple valve diseases	0.739	0.261
I95-I99 Other and unspecified disorders of the circulatory system	0.739	0.261
F33 Recurrent depressive disorder	0.739	0.261
Q60-Q64 Congenital malformations of the urinary system	0.737	0.263
S02 Fracture of skull and facial bones	0.735	0.264
M24.2 Disorder of ligament	0.735	0.265
X20-X29 Contact with venomous animals and plants	0.734	0.266
E14 Unspecified diabetes mellitus	0.734	0.266
E10.9 Without complications	0.733	0.267
Chapter X Diseases of the respiratory system	0.733	0.267
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.733	0.267
F10.0 Acute intoxication	0.732	0.268
S82 Fracture of lower leg, including ankle	0.732	0.268
T81.3 Disruption of operation wound, not elsewhere classified	0.730	0.270
M84.1 Nonunion of fracture [pseudarthrosis]	0.729	0.271
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.729	0.271
T90 Sequelae of injuries of head	0.728	0.271
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.728	0.272
I25.2 Old myocardial infarction	0.727	0.273
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.727	0.273
T94 Sequelae of injuries involving multiple and unspecified body regions	0.726	0.274
F99-F99 Unspecified mental disorder	0.726	0.274
X40-X49 Accidental poisoning by and exposure to noxious substances	0.724	0.276
I74 Arterial embolism and thrombosis	0.724	0.276
S70-S79 Injuries to the hip and thigh	0.723	0.277
S42.3 Fracture of shaft of humerus	0.722	0.278
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.720	0.280
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts	0.720	0.280
K82.8 Other specified diseases of gallbladder	0.718	0.282
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.718	0.282
S00.8 Superficial injury of other parts of head	0.717	0.283
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.717	0.283
M33 Dermatopolymyositis	0.717	0.283
M32 Systemic lupus erythematosus	0.717	0.283
M30 Polyarteritis nodosa and related conditions	0.717	0.283
M60-M63 Disorders of muscles	0.717	0.283
M00-M03 Infectious arthropathies	0.717	0.283
T33-T35 Frostbite	0.717	0.283
T26-T28 Burns and corrosions confined to eye and internal organs	0.717	0.283
T20-T25 Burns and corrosions of external body surface, specified by site	0.717	0.283
T00-T07 Injuries involving multiple body regions	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
I00-I02 Acute rheumatic fever	0.717	0.283
M23.9 Internal derangement of knee, unspecified	0.717	0.283
M23.6 Other spontaneous disruption of ligament(s) of knee	0.717	0.283
M23.5 Chronic instability of knee	0.717	0.283
M23.1 Discoid meniscus (congenital)	0.717	0.283
M23.0 Cystic meniscus	0.717	0.283
M25.9 Joint disorder, unspecified	0.716	0.284
M25.3 Other instability of joint	0.716	0.284
M25.2 Flail joint	0.716	0.284
M25.1 Fistula of joint	0.716	0.284
M25.0 Haemarthrosis	0.716	0.284
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.716	0.284
S81 Open wound of lower leg	0.716	0.284
I84.0 Internal thrombosed haemorrhoids	0.715	0.285
F80-F89 Disorders of psychological development	0.715	0.285
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts	0.713	0.287
M25.58 Pain in joint (Other)	0.712	0.287
M25.52 Pain in joint (Upper arm)	0.712	0.287
M13.9 Arthritis, unspecified	0.712	0.288
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.712	0.288
M85 Other disorders of bone density and structure	0.712	0.288
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.710	0.290
F70-F79 Mental retardation	0.710	0.290
I84.3 External thrombosed haemorrhoids	0.710	0.290
K75 Other inflammatory liver diseases	0.709	0.291
M12 Other specific arthropathies	0.709	0.291
M09 Juvenile arthritis in diseases classified elsewhere	0.709	0.291
M08 Juvenile arthritis	0.709	0.291
M25.57 Pain in joint (Ankle and foot)	0.708	0.292
J40-J47 Chronic lower respiratory diseases	0.708	0.292
M24.16 Other articular cartilage disorders (Lower leg)	0.708	0.292
J45 Asthma	0.708	0.292
I89.0 Lymphoedema, not elsewhere classified	0.707	0.293
I23 Certain current complications following acute myocardial infarction	0.707	0.293
I15 Secondary hypertension	0.706	0.294
I13 Hypertensive heart and renal disease	0.706	0.294
I11 Hypertensive heart disease	0.706	0.294
T87 Complications peculiar to reattachment and amputation	0.705	0.295
T80 Complications following infusion, transfusion and therapeutic injection	0.705	0.295
K76 Other diseases of liver	0.705	0.295
F60-F69 Disorders of adult personality and behaviour	0.705	0.295
H60 Otitis externa	0.704	0.296
T68 Hypothermia	0.703	0.297
E13 Other specified diabetes mellitus	0.702	0.298
M10.4 Other secondary gout	0.701	0.299
M10.3 Gout due to impairment of renal function	0.701	0.299
M10.2 Drug-induced gout	0.701	0.299
M10.1 Lead-induced gout	0.701	0.299
M10.0 Idiopathic gout	0.701	0.299
M70-M79 Other soft tissue disorders	0.700	0.300
V20-V29 Motorcycle rider injured in transport accident	0.700	0.300
J45.9 Asthma, unspecified	0.699	0.301
I71.0 Dissection of aorta [any part]	0.699	0.301
Y88 Sequelae of surgical and medical care as external cause	0.698	0.302
T15-T19 Effects of foreign body entering through natural orifice	0.698	0.302
I88 Nonspecific lymphadenitis	0.697	0.303
I81 Portal vein thrombosis	0.697	0.303
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.696	0.304
M10.98 Gout, unspecified (Other)	0.696	0.304
M10.96 Gout, unspecified (Lower leg)	0.696	0.304
M10.95 Gout, unspecified (Pelvic region and thigh)	0.696	0.304
M10.94 Gout, unspecified (Hand)	0.696	0.304
M10.93 Gout, unspecified (Forearm)	0.696	0.304
M10.92 Gout, unspecified (Upper arm)	0.696	0.304
M10.91 Gout, unspecified (Shoulder region)	0.696	0.304
M10.90 Gout, unspecified (Multiple sites)	0.696	0.304
I12 Hypertensive renal disease	0.696	0.304
F52 Sexual dysfunction, not caused by organic disorder or disease	0.695	0.305
T92 Sequelae of injuries of upper limb	0.693	0.307
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.693	0.307
S08 Traumatic amputation of part of head	0.693	0.307
S07 Crushing injury of head	0.693	0.307
S05 Injury of eye and orbit	0.693	0.307
S04 Injury of cranial nerves	0.693	0.307
S03 Dislocation, sprain and strain of joints and ligaments of head	0.693	0.307
T88 Other complications of surgical and medical care, not elsewhere classified	0.692	0.308
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.692	0.308
Y35-Y36 Legal intervention and operations of war	0.692	0.308
Y10-Y34 Event of undetermined intent	0.692	0.308
Y00-Y09 Assault	0.692	0.308
X85-X99 Assault	0.692	0.308
X58-X59 Accidental exposure to other and unspecified factors	0.692	0.308
X50-X57 Overexertion, travel and privation	0.692	0.308
X30-X39 Exposure to forces of nature	0.692	0.308
X10-X19 Contact with heat and hot substances	0.692	0.308
X00-X09 Exposure to smoke, fire and flames	0.692	0.308
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.692	0.308
W75-W84 Other accidental threats to breathing	0.692	0.308
W65-W74 Accidental drowning and submersion	0.692	0.308
V98-V99 Other and unspecified transport accidents	0.692	0.308
V95-V97 Air and space transport accidents	0.692	0.308
V90-V94 Water transport accidents	0.692	0.308
V80-V89 Other land transport accidents	0.692	0.308
V70-V79 Bus occupant injured in transport accident	0.692	0.308
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.692	0.308
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.692	0.308
V40-V49 Car occupant injured in transport accident	0.692	0.308
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.692	0.308
V01-V09 Pedestrian injured in transport accident	0.692	0.308
S69 Other and unspecified injuries of wrist and hand	0.691	0.309
S67 Crushing injury of wrist and hand	0.691	0.309
S65 Injury of blood vessels at wrist and hand level	0.691	0.309
M65 Synovitis and tenosynovitis	0.691	0.309
G90-G99 Other disorders of the nervous system	0.691	0.309
K72.9 Hepatic failure, unspecified	0.690	0.310
S06 Intracranial injury	0.689	0.310
S66 Injury of muscle and tendon at wrist and hand level	0.689	0.311
S01.5 Open wound of lip and oral cavity	0.689	0.311
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.689	0.311
F18 Mental and behavioural disorders due to use of volatile solvents	0.689	0.311
F16 Mental and behavioural disorders due to use of hallucinogens	0.689	0.311
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine	0.689	0.311
F14 Mental and behavioural disorders due to use of cocaine	0.689	0.311
F13 Mental and behavioural disorders due to use of sedatives or hypnotics	0.689	0.311
F12 Mental and behavioural disorders due to use of cannabinoids	0.689	0.311
F11 Mental and behavioural disorders due to use of opioids	0.689	0.311
M13.99 Arthritis, unspecified (Site unspecified)	0.689	0.311
F32.3 Severe depressive episode with psychotic symptoms	0.688	0.312
T93 Sequelae of injuries of lower limb	0.688	0.312
K86.2 Cyst of pancreas	0.687	0.313
T91 Sequelae of injuries of neck and trunk	0.687	0.313
M05 Seropositive rheumatoid arthritis	0.685	0.315
M21 Other acquired deformities of limbs	0.685	0.315
O20-O29 Other maternal disorders predominantly related to pregnancy	0.685	0.315
F00-F09 Organic, including symptomatic, mental disorders	0.684	0.316
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.684	0.316
Q00-Q07 Congenital malformations of the nervous system	0.681	0.318
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.681	0.319
K70.3 Alcoholic cirrhosis of liver	0.678	0.322
I87 Other disorders of veins	0.678	0.322
F32.1 Moderate depressive episode	0.677	0.323
K80 Cholelithiasis	0.677	0.323
K82.1 Hydrops of gallbladder	0.677	0.323
Chapter VII Diseases of the eye and adnexa	0.676	0.324
M47 Spondylosis	0.676	0.324
F32.0 Mild depressive episode	0.676	0.324
S64.9 Injury of unspecified nerve at wrist and hand level	0.675	0.325
S64.8 Injury of other nerves at wrist and hand level	0.675	0.325
S64.7 Injury of multiple nerves at wrist and hand level	0.675	0.325
S64.3 Injury of digital nerve of thumb	0.675	0.325
S64.1 Injury of median nerve at wrist and hand level	0.675	0.325
S64.0 Injury of ulnar nerve at wrist and hand level	0.675	0.325
E20-E35 Disorders of other endocrine glands	0.673	0.327
O80 Single spontaneous delivery	0.672	0.328
Y85 Sequelae of transport accidents	0.672	0.328
Y89 Sequelae of other external causes	0.672	0.328
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.672	0.328
M25.46 Effusion of joint (Lower leg)	0.672	0.328
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.671	0.329
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.671	0.329
I82 Other venous embolism and thrombosis	0.670	0.330
F38 Other mood [affective] disorders	0.669	0.331
F34 Persistent mood [affective] disorders	0.669	0.331
F30 Manic episode	0.669	0.331
F39 Unspecified mood [affective] disorder	0.669	0.331
M24.17 Other articular cartilage disorders (Ankle and foot)	0.668	0.332
W19 Unspecified fall	0.668	0.332
K67 Disorders of peritoneum in infectious diseases classified elsewhere	0.667	0.333
T86.1 Kidney transplant failure and rejection	0.667	0.333
I08.0 Disorders of both mitral and aortic valves	0.666	0.334
H61.0 Perichondritis of external ear	0.666	0.334
S42.30 Fracture of shaft of humerus (closed)	0.665	0.335
E10.1 With ketoacidosis	0.665	0.335
K66.8 Other specified disorders of peritoneum	0.665	0.335
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.664	0.335
M11 Other crystal arthropathies	0.664	0.336
E11 Non-insulin-dependent diabetes mellitus	0.663	0.337
T84.3 Mechanical complication of other bone devices, implants and grafts	0.662	0.338
M13.0 Polyarthritis, unspecified	0.662	0.338
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.661	0.339
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.661	0.339
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.661	0.339
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.661	0.339
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.661	0.339
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.661	0.339
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.661	0.339
K66.9 Disorder of peritoneum, unspecified	0.661	0.339
K66.1 Haemoperitoneum	0.661	0.339
S01.7 Multiple open wounds of head	0.660	0.340
S01.4 Open wound of cheek and temporomandibular area	0.660	0.340
S01.3 Open wound of ear	0.660	0.340
S42.1 Fracture of scapula	0.660	0.340
M25.76 Osteophyte (Lower leg)	0.659	0.341
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.659	0.341
I24.1 Dressler's syndrome	0.659	0.341
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.659	0.341
I72 Other aneurysm	0.659	0.341
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.659	0.341
M07 Psoriatic and enteropathic arthropathies	0.658	0.342
I25.0 Atherosclerotic cardiovascular disease, so described	0.658	0.342
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.658	0.342
S01.9 Open wound of head, part unspecified	0.657	0.343
T86.8 Failure and rejection of other transplanted organs and tissues	0.657	0.343
K77 Liver disorders in diseases classified elsewhere	0.656	0.344
K73 Chronic hepatitis, not elsewhere classified	0.656	0.344
K71 Toxic liver disease	0.656	0.344
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere	0.655	0.344
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.655	0.345
S01.2 Open wound of nose	0.655	0.345
S19 Other and unspecified injuries of neck	0.655	0.345
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.655	0.345
J45.0 Predominantly allergic asthma	0.654	0.346
S60.8 Other superficial injuries of wrist and hand	0.654	0.346
M24.9 Joint derangement, unspecified	0.654	0.346
M24.8 Other specific joint derangements, not elsewhere classified	0.654	0.346
M24.7 Protrusio acetabuli	0.654	0.346
M24.6 Ankylosis of joint	0.654	0.346
M24.5 Contracture of joint	0.654	0.346
M24.4 Recurrent dislocation and subluxation of joint	0.654	0.346
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.654	0.346
M24.0 Loose body in joint	0.654	0.346
G30-G32 Other degenerative diseases of the nervous system	0.653	0.347
Q50-Q56 Congenital malformations of genital organs	0.651	0.349
M25.87 Other specified joint disorders (Ankle and foot)	0.651	0.349
T78 Adverse effects, not elsewhere classified	0.650	0.350
M23.49 Loose body in knee-Unspec lig/men	0.650	0.350
K82.9 Disease of gallbladder, unspecified	0.649	0.351
T98 Sequelae of other and unspecified effects of external causes	0.647	0.353
T95 Sequelae of burns, corrosions and frostbite	0.647	0.353
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.647	0.353
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.647	0.353
F17.9 Unspecified mental and behavioural disorder	0.647	0.353
F17.8 Other mental and behavioural disorders	0.647	0.353
F17.7 Residual and late-onset psychotic disorder	0.647	0.353
F17.6 Amnesic syndrome	0.647	0.353
F17.5 Psychotic disorder	0.647	0.353
F17.4 Withdrawal state with delirium	0.647	0.353
F17.3 Withdrawal state	0.647	0.353
F17.0 Acute intoxication	0.647	0.353
Q61 Cystic kidney disease	0.647	0.353
G93 Other disorders of brain	0.645	0.355
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.644	0.356
S48 Traumatic amputation of shoulder and upper arm	0.643	0.356
S46 Injury of muscle and tendon at shoulder and upper arm level	0.643	0.356
S45 Injury of blood vessels at shoulder and upper arm level	0.643	0.356
S44 Injury of nerves at shoulder and upper arm level	0.643	0.356
S41 Open wound of shoulder and upper arm	0.643	0.356
S40 Superficial injury of shoulder and upper arm	0.643	0.356
S47 Crushing injury of shoulder and upper arm	0.643	0.356
S49.9 Unspecified injury of shoulder and upper arm	0.643	0.357
O94-O99 Other obstetric conditions, not elsewhere classified	0.643	0.357
F32.8 Other depressive episodes	0.642	0.358
E40-E46 Malnutrition	0.641	0.359
M83 Adult osteomalacia	0.640	0.359
M82 Osteoporosis in diseases classified elsewhere	0.640	0.359
V10-V19 Pedal cyclist injured in transport accident	0.640	0.360
I07 Rheumatic tricuspid valve diseases	0.638	0.362
K74.6 Other and unspecified cirrhosis of liver	0.638	0.362
E10.3 With ophthalmic complications	0.637	0.363
I20.1 Angina pectoris with documented spasm	0.637	0.363
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified	0.637	0.363
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified	0.637	0.363
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.637	0.363
E10.5 With peripheral circulatory complications	0.636	0.364
F10.2 Dependence syndrome	0.636	0.364
M23.8 Other internal derangements of knee	0.635	0.365
K81.0 Acute cholecystitis	0.635	0.365
M65.9 Synovitis and tenosynovitis, unspecified	0.634	0.366
S62.3 Fracture of other metacarpal bone	0.634	0.366
S12 Fracture of neck	0.631	0.368
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.631	0.369
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.630	0.370
M80 Osteoporosis with pathological fracture	0.630	0.370
M06 Other rheumatoid arthritis	0.629	0.370
I21.1 Acute transmural myocardial infarction of inferior wall	0.629	0.371
J30-J39 Other diseases of upper respiratory tract	0.629	0.371
M81 Osteoporosis without pathological fracture	0.628	0.372
H93 Other disorders of ear, not elsewhere classified	0.628	0.372
F32.2 Severe depressive episode without psychotic symptoms	0.628	0.372
S89 Other and unspecified injuries of lower leg	0.627	0.373
S88 Traumatic amputation of lower leg	0.627	0.373
S87 Crushing injury of lower leg	0.627	0.373
S86 Injury of muscle and tendon at lower leg level	0.627	0.373
S85 Injury of blood vessels at lower leg level	0.627	0.373
S84 Injury of nerves at lower leg level	0.627	0.373
T46 Poisoning by agents primarily affecting the cardiovascular system	0.627	0.373
T85.9 Unspecified complication of internal prosthetic device, implant and graft	0.626	0.374
T85.2 Mechanical complication of intraocular lens	0.626	0.374
T85.1 Mechanical complication of implanted electronic stimulator of nervous system	0.626	0.374
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt	0.626	0.374
S09 Other and unspecified injuries of head	0.626	0.374
M40-M43 Deforming dorsopathies	0.625	0.375
S80 Superficial injury of lower leg	0.625	0.375
T82.4 Mechanical complication of vascular dialysis catheter	0.624	0.376
H92 Otalgia and effusion of ear	0.624	0.376
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.624	0.376
K85 Acute pancreatitis	0.624	0.376
M90 Osteopathies in diseases classified elsewhere	0.622	0.378
K70.0 Alcoholic fatty liver	0.622	0.378
I20.8 Other forms of angina pectoris	0.622	0.378
K91 Postprocedural disorders of digestive system, not elsewhere classified	0.621	0.379
G35-G37 Demyelinating diseases of the central nervous system	0.621	0.379
M25.51 Pain in joint (Shoulder region)	0.620	0.379
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.620	0.380
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.620	0.380
K86.3 Pseudocyst of pancreas	0.619	0.380
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.619	0.380
Q80-Q89 Other congenital malformations	0.619	0.380
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.619	0.380
Q38-Q45 Other congenital malformations of the digestive system	0.619	0.380
Q35-Q37 Cleft lip and cleft palate	0.619	0.380
Q30-Q34 Congenital malformations of the respiratory system	0.619	0.380
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.619	0.380
S00.2 Other superficial injuries of eyelid and periocular area	0.619	0.381
O80.0 Spontaneous vertex delivery	0.619	0.381
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.618	0.382
I60-I69 Cerebrovascular diseases	0.618	0.382
I25.9 Chronic ischaemic heart disease, unspecified	0.618	0.382
F10.9 Unspecified mental and behavioural disorder	0.618	0.382
F10.8 Other mental and behavioural disorders	0.618	0.382
F10.7 Residual and late-onset psychotic disorder	0.618	0.382
F10.6 Amnesic syndrome	0.618	0.382

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations