TreeWAS – Variant ID: rs10231759

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Showing all nodes without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
G56.0 Carpal tunnel syndrome	0.000	0.913	0.087
I35.0 Aortic (valve) stenosis	0.000	0.937	0.063
I35.2 Aortic (valve) stenosis with insufficiency	0.000	0.943	0.057
I35 Nonrheumatic aortic valve disorders	0.000	0.943	0.057
I35.9 Aortic valve disorder, unspecified	0.000	0.949	0.051
I35.8 Other aortic valve disorders	0.000	0.958	0.042
N13.8 Other obstructive and reflux uropathy	0.000	0.973	0.027
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.000	0.976	0.024
N13.5 Kinking and stricture of ureter without hydronephrosis	0.000	0.977	0.023
N13 Obstructive and reflux uropathy	0.000	0.979	0.021
N13.0 Hydronephrosis with ureteropelvic junction obstruction	0.000	0.979	0.021
R10.2 Pelvic and perineal pain	0.000	0.981	0.019
N13.4 Hydroureter	0.000	0.982	0.018
M80.9 Unspecified osteoporosis with pathological fracture	0.000	0.983	0.017
G56 Mononeuropathies of upper limb	0.000	0.983	0.017
N13.3 Other and unspecified hydronephrosis	0.000	0.983	0.017
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.000	0.984	0.016
R00.8 Other and unspecified abnormalities of heart beat	0.000	0.984	0.016
I35.1 Aortic (valve) insufficiency	0.000	0.984	0.016
O16 Unspecified maternal hypertension	0.016	0.984	0.000
N13.7 Vesicoureteral-reflux-associated uropathy	0.000	0.984	0.016
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.000	0.987	0.013
G56.4 Causalgia	0.000	0.987	0.013
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.000	0.987	0.013
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.000	0.987	0.013
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.000	0.987	0.013
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.000	0.987	0.013
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.000	0.987	0.013
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.000	0.987	0.013
G56.8 Other mononeuropathies of upper limb	0.000	0.987	0.012
G56.1 Other lesions of median nerve	0.000	0.988	0.012
G56.9 Mononeuropathy of upper limb, unspecified	0.000	0.988	0.012
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.989	0.011
G56.3 Lesion of radial nerve	0.000	0.989	0.011
N13.6 Pyonephrosis	0.000	0.989	0.011
N13.9 Obstructive and reflux uropathy, unspecified	0.000	0.990	0.010
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.010	0.990	0.000
Z96.6 Presence of orthopaedic joint implants	0.000	0.991	0.009
D50.8 Other iron deficiency anaemias	0.000	0.991	0.009
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.009	0.991	0.000
K35.0 Acute appendicitis with generalised peritonitis	0.009	0.991	0.000
K83.8 Other specified diseases of biliary tract	0.000	0.992	0.008
N13.2 Hydronephrosis with renal and ureteral calculous obstruction	0.000	0.992	0.008
I84.3 External thrombosed haemorrhoids	0.008	0.992	0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.008	0.992	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.007	0.992	0.000
K62.9 Disease of anus and rectum, unspecified	0.007	0.993	0.000
G56.2 Lesion of ulnar nerve	0.000	0.993	0.007
O15 Eclampsia	0.007	0.993	0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.006	0.994	0.000
O10.0 Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium	0.006	0.994	0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.006	0.994	0.000
O10.9 Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.006	0.994	0.000
O10.4 Pre-existing secondary hypertension complicating pregnancy, childbirth and the puerperium	0.006	0.994	0.000
O10.3 Pre-existing hypertensive heart and renal disease complicating pregnancy, childbirth and the puerperium	0.006	0.994	0.000
O10.2 Pre-existing hypertensive renal disease complicating pregnancy, childbirth and the puerperium	0.006	0.994	0.000
O10.1 Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium	0.006	0.994	0.000
R73.0 Abnormal glucose tolerance test	0.006	0.994	0.000
O15.9 Eclampsia, unspecified as to time period	0.005	0.995	0.000
O15.2 Eclampsia in the puerperium	0.005	0.995	0.000
O15.1 Eclampsia in labour	0.005	0.995	0.000
O15.0 Eclampsia in pregnancy	0.005	0.995	0.000
I45.9 Conduction disorder, unspecified	0.000	0.995	0.005
O14.0 Moderate preeclampsia	0.005	0.995	0.000
M17.1 Other primary gonarthrosis	0.000	0.995	0.005
O12.0 Gestational oedema	0.005	0.995	0.000
O14.2 HELLP syndrome	0.005	0.995	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.995	0.005
H43.8 Other disorders of vitreous body	0.005	0.995	0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified	0.001	0.995	0.004
O12.2 Gestational oedema with proteinuria	0.004	0.995	0.000
H90.5 Sensorineural hearing loss, unspecified	0.005	0.995	0.000
O14.1 Severe preeclampsia	0.004	0.996	0.000
G63.2 Diabetic polyneuropathy	0.004	0.996	0.000
O12.1 Gestational proteinuria	0.004	0.996	0.000
G62.9 Polyneuropathy, unspecified	0.004	0.996	0.000
M17.5 Other secondary gonarthrosis	0.000	0.996	0.004
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.000	0.996	0.004
O14.9 Preeclampsia, unspecified	0.004	0.996	0.000
G63 Polyneuropathy in diseases classified elsewhere	0.003	0.997	0.000
N81.4 Uterovaginal prolapse, unspecified	0.000	0.997	0.003
M17 Gonarthrosis [arthrosis of knee]	0.000	0.997	0.003
Q12.0 Congenital cataract	0.003	0.997	0.000
Q87.4 Marfan's syndrome	0.003	0.997	0.000
M17.4 Other secondary gonarthrosis, bilateral	0.000	0.997	0.003
Q12 Congenital lens malformations	0.003	0.997	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.000	0.997	0.003
G62 Other polyneuropathies	0.003	0.997	0.000
Z73.3 Stress, not elsewhere classified	0.003	0.997	0.000
M17.9 Gonarthrosis, unspecified	0.000	0.997	0.003
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.003	0.997	0.000
N70.1 Chronic salpingitis and oophoritis	0.000	0.997	0.003
G62.0 Drug-induced polyneuropathy	0.003	0.997	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.003	0.997	0.000
G63.8 Polyneuropathy in other diseases classified elsewhere	0.003	0.997	0.000
G63.6 Polyneuropathy in other musculoskeletal disorders	0.003	0.997	0.000
G63.5 Polyneuropathy in systemic connective tissue disorders	0.003	0.997	0.000
G63.4 Polyneuropathy in nutritional deficiency	0.003	0.997	0.000
G63.3 Polyneuropathy in other endocrine and metabolic diseases	0.003	0.997	0.000
G63.1 Polyneuropathy in neoplastic disease	0.003	0.997	0.000
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere	0.003	0.997	0.000
Q17 Other congenital malformations of ear	0.003	0.997	0.000
Z04.8 Examination and observation for other specified reasons	0.003	0.997	0.000
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.000	0.997	0.003
Q15 Other congenital malformations of eye	0.003	0.997	0.000
M80 Osteoporosis with pathological fracture	0.000	0.997	0.003
N31.8 Other neuromuscular dysfunction of bladder	0.003	0.997	0.000
Q17.5 Prominent ear	0.003	0.997	0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems	0.003	0.997	0.000
K70.3 Alcoholic cirrhosis of liver	0.003	0.997	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.997	0.003
Q50-Q56 Congenital malformations of genital organs	0.003	0.997	0.000
Q50.4 Embryonic cyst of Fallopian tube	0.003	0.997	0.000
Q52 Other congenital malformations of female genitalia	0.003	0.997	0.000
M17.2 Posttraumatic gonarthrosis, bilateral	0.000	0.997	0.002
Q15.0 Congenital glaucoma	0.003	0.997	0.000
G20 Parkinson's disease	0.000	0.997	0.003
Q55 Other congenital malformations of male genital organs	0.003	0.997	0.000
Q54 Hypospadias	0.003	0.997	0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.003	0.997	0.000
M17.3 Other posttraumatic gonarthrosis	0.000	0.997	0.002
S32.50 Fracture of pubis (closed)	0.000	0.997	0.003
E27.1 Primary adrenocortical insufficiency	0.000	0.997	0.003
Q54.9 Hypospadias, unspecified	0.002	0.997	0.000
Q12.9 Congenital lens malformation, unspecified	0.002	0.997	0.000
Q12.8 Other congenital lens malformations	0.002	0.997	0.000
Q12.4 Spherophakia	0.002	0.997	0.000
Q12.3 Congenital aphakia	0.002	0.997	0.000
Q12.2 Coloboma of lens	0.002	0.997	0.000
Q12.1 Congenital displaced lens	0.002	0.997	0.000
Y48.2 Other and unspecified general anaesthetics	0.000	0.997	0.002
Q55.6 Other congenital malformations of penis	0.002	0.997	0.000
Q85.0 Neurofibromatosis (nonmalignant)	0.002	0.997	0.000
G61 Inflammatory polyneuropathy	0.002	0.997	0.000
K74.6 Other and unspecified cirrhosis of liver	0.002	0.998	0.000
Y60.0 During surgical operation	0.002	0.998	0.000
G62.2 Polyneuropathy due to other toxic agents	0.002	0.998	0.000
Q14 Congenital malformations of posterior segment of eye	0.002	0.998	0.000
Q52.5 Fusion of labia	0.002	0.998	0.000
Y48.4 Anaesthetic, unspecified	0.000	0.998	0.002
Y40.8 Other systemic antibiotics	0.000	0.998	0.002
H11.4 Other conjunctival vascular disorders and cysts	0.002	0.998	0.000
H43.9 Disorder of vitreous body, unspecified	0.002	0.998	0.000
H43 Disorders of vitreous body	0.002	0.998	0.000
Q85 Phakomatoses, not elsewhere classified	0.002	0.998	0.000
H34.8 Other retinal vascular occlusions	0.000	0.998	0.002
Q16 Congenital malformations of ear causing impairment of hearing	0.002	0.998	0.000
Q13 Congenital malformations of anterior segment of eye	0.002	0.998	0.000
Q11 Anophthalmos, microphthalmos and macrophthalmos	0.002	0.998	0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit	0.002	0.998	0.000
N10-N16 Renal tubulo-interstitial diseases	0.000	0.998	0.002
Q52.1 Doubling of vagina	0.002	0.998	0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level	0.002	0.998	0.000
Q80-Q89 Other congenital malformations	0.002	0.998	0.000
G61.8 Other inflammatory polyneuropathies	0.002	0.998	0.000
K76.6 Portal hypertension	0.002	0.998	0.000
G62.1 Alcoholic polyneuropathy	0.002	0.998	0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care	0.002	0.998	0.000
G93.8 Other specified disorders of brain	0.000	0.998	0.002
X62.9 Unspecified place	0.000	0.998	0.002
G61.9 Inflammatory polyneuropathy, unspecified	0.002	0.998	0.000
G64 Other disorders of peripheral nervous system	0.002	0.998	0.000
Q17.9 Congenital malformation of ear, unspecified	0.002	0.998	0.000
Q17.8 Other specified congenital malformations of ear	0.002	0.998	0.000
Q17.4 Misplaced ear	0.002	0.998	0.000
Q17.3 Other misshapen ear	0.002	0.998	0.000
Q17.2 Microtia	0.002	0.998	0.000
Q17.1 Macrotia	0.002	0.998	0.000
Q17.0 Accessory auricle	0.002	0.998	0.000
G60.8 Other hereditary and idiopathic neuropathies	0.002	0.998	0.000
Y60.8 During other surgical and medical care	0.002	0.998	0.000
G60 Hereditary and idiopathic neuropathy	0.002	0.998	0.000
Q18 Other congenital malformations of face and neck	0.002	0.998	0.000
Q15.9 Congenital malformation of eye, unspecified	0.002	0.998	0.000
Q15.8 Other specified congenital malformations of eye	0.002	0.998	0.000
R73 Elevated blood glucose level	0.002	0.998	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.000	0.998	0.002
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.000	0.998	0.002
M80.2 Osteoporosis of disuse with pathological fracture	0.000	0.998	0.002
Z73.9 Problem related to life-management difficulty, unspecified	0.002	0.998	0.000
Q87.5 Other congenital malformation syndromes with other skeletal changes	0.002	0.998	0.000
Q87.3 Congenital malformation syndromes involving early overgrowth	0.002	0.998	0.000
Q87.2 Congenital malformation syndromes predominantly involving limbs	0.002	0.998	0.000
Q87.1 Congenital malformation syndromes predominantly associated with short stature	0.002	0.998	0.000
U80.1 Methicillin resistant agent	0.002	0.998	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.998	0.002
Q53 Undescended testicle	0.002	0.998	0.000
Y48 Anaesthetics and therapeutic gases	0.000	0.998	0.002
Q56 Indeterminate sex and pseudohermaphroditism	0.002	0.998	0.000
Q54.0 Hypospadias, balanic	0.002	0.998	0.000
Q52.9 Congenital malformation of female genitalia, unspecified	0.002	0.998	0.000
Q52.8 Other specified congenital malformations of female genitalia	0.002	0.998	0.000
Q52.7 Other congenital malformations of vulva	0.002	0.998	0.000
Q52.6 Congenital malformation of clitoris	0.002	0.998	0.000
Q52.4 Other congenital malformations of vagina	0.002	0.998	0.000
Q52.3 Imperforate hymen	0.002	0.998	0.000
Q52.2 Congenital rectovaginal fistula	0.002	0.998	0.000
Q52.0 Congenital absence of vagina	0.002	0.998	0.000
Q55.2 Other congenital malformations of testis and scrotum	0.002	0.998	0.000
Q87.8 Other specified congenital malformation syndromes, not elsewhere classified	0.002	0.998	0.000
Y60.5 During heart catheterisation	0.002	0.998	0.000
Q14.1 Congenital malformation of retina	0.002	0.998	0.000
Q50.6 Other congenital malformatons of Fallopian tube and broad ligament	0.002	0.998	0.000
Q50.3 Other congenital malformations of ovary	0.002	0.998	0.000
Q50.2 Congenital torsion of ovary	0.002	0.998	0.000
Q50.1 Developmental ovarian cyst	0.002	0.998	0.000
Q50.0 Congenital absence of ovary	0.002	0.998	0.000
Q54.8 Other hypospadias	0.002	0.998	0.000
Q54.4 Congenital chordee	0.002	0.998	0.000
Q54.3 Hypospadias, perineal	0.002	0.998	0.000
Q54.2 Hypospadias, penoscrotal	0.002	0.998	0.000
Q55.9 Congenital malformation of male genital organ, unspecified	0.002	0.998	0.000
Q55.8 Other specified congenital malformations of male genital organs	0.002	0.998	0.000
Q55.5 Congenital absence and aplasia of penis	0.002	0.998	0.000
Q55.4 Other congenital malformations of vas deferens, epididymis, seminal vesicles and prostate	0.002	0.998	0.000
Q55.3 Atresia of vas deferens	0.002	0.998	0.000
Q55.1 Hypoplasia of testis and scrotum	0.002	0.998	0.000
Q55.0 Absence and aplasia of testis	0.002	0.998	0.000
Q87.0 Congenital malformation syndromes predominantly affecting facial appearance	0.002	0.998	0.000
Y60.4 During endoscopic examination	0.002	0.998	0.000
Q54.1 Hypospadias, penile	0.002	0.998	0.000
Z94.4 Liver transplant status	0.002	0.998	0.000
G61.1 Serum neuropathy	0.002	0.998	0.000
Y52 Agents primarily affecting the cardiovascular system	0.000	0.998	0.002
H43.2 Crystalline deposits in vitreous body	0.002	0.998	0.000
Q14.9 Congenital malformation of posterior segment of eye, unspecified	0.002	0.998	0.000
Q14.8 Other congenital malformations of posterior segment of eye	0.002	0.998	0.000
Q14.3 Congenital malformation of choroid	0.002	0.998	0.000
Q14.2 Congenital malformation of optic disk	0.002	0.998	0.000
Q14.0 Congenital malformation of vitreous humour	0.002	0.998	0.000
Q53.9 Undescended testicle, unspecified	0.002	0.998	0.000
I45.6 Preexcitation syndrome	0.000	0.998	0.002
Q85.8 Other phakomatoses, not elsewhere classified	0.002	0.998	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.002	0.998	0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions	0.000	0.998	0.002
H43.0 Vitreous prolapse	0.002	0.998	0.000
K83 Other diseases of biliary tract	0.000	0.998	0.002
M80.8 Other osteoporosis with pathological fracture	0.000	0.998	0.002
Q10.7 Congenital malformation of orbit	0.002	0.998	0.000
Q10.6 Other congenital malformations of lachrymal apparatus	0.002	0.998	0.000
Q10.5 Congenital stenosis and stricture of lachrymal duct	0.002	0.998	0.000
Q10.4 Absence and agenesis of lachrymal apparatus	0.002	0.998	0.000
Q10.3 Other congenital malformations of eyelid	0.002	0.998	0.000
Q10.2 Congenital entropion	0.002	0.998	0.000
Q10.1 Congenital ectropion	0.002	0.998	0.000
Q11.3 Macrophthalmos	0.002	0.998	0.000
Q11.2 Microphthalmos	0.002	0.998	0.000
Q11.1 Other anophthalmos	0.002	0.998	0.000
Q11.0 Cystic eyeball	0.002	0.998	0.000
Q13.9 Congenital malformation of anterior segment of eye, unspecified	0.002	0.998	0.000
Q13.8 Other congenital malformations of anterior segment of eye	0.002	0.998	0.000
Q13.5 Blue sclera	0.002	0.998	0.000
Q13.4 Other congenital corneal malformations	0.002	0.998	0.000
Q13.3 Congenital corneal opacity	0.002	0.998	0.000
Q13.2 Other congenital malformations of iris	0.002	0.998	0.000
Q13.1 Absence of iris	0.002	0.998	0.000
Q13.0 Coloboma of iris	0.002	0.998	0.000
Q16.9 Congenital malformation of ear causing impairment of hearing, unspecified	0.002	0.998	0.000
Q16.5 Congenital malformation of inner ear	0.002	0.998	0.000
Q16.4 Other congenital malformations of middle ear	0.002	0.998	0.000
Q16.3 Congenital malformation of ear ossicles	0.002	0.998	0.000
Q16.2 Absence of eustachian tube	0.002	0.998	0.000
Q16.1 Congenital absence, atresia and stricture of auditory canal (external)	0.002	0.998	0.000
Q16.0 Congenital absence of (ear) auricle	0.002	0.998	0.000
Q85.1 Tuberous sclerosis	0.002	0.998	0.000
R22.0 Localised swelling, mass and lump, head	0.000	0.998	0.002
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere	0.000	0.998	0.002
Q86 Congenital malformation syndromes due to known exogenous causes, not elsewhere classified	0.002	0.998	0.000
Q84 Other congenital malformations of integument	0.002	0.998	0.000
Q81 Epidermolysis bullosa	0.002	0.998	0.000
Q80 Congenital ichthyosis	0.002	0.998	0.000
Q10.0 Congenital ptosis	0.002	0.998	0.000
Q83 Congenital malformations of breast	0.002	0.998	0.000
Q18.1 Preauricular sinus and cyst	0.002	0.998	0.000
Q50.5 Embryonic cyst of broad ligament	0.002	0.998	0.000
Y60.9 During unspecified surgical and medical care	0.002	0.998	0.000
Y60.7 During administration of enema	0.002	0.998	0.000
Y60.6 During aspiration, puncture and other catheterisation	0.002	0.998	0.000
Y60.3 During injection or immunisation	0.002	0.998	0.000
Y60.2 During kidney dialysis or other perfusion	0.002	0.998	0.000
Y60.1 During infusion or transfusion	0.002	0.998	0.000
N15 Other renal tubulo-interstitial diseases	0.000	0.998	0.002
M80.5 Idiopathic osteoporosis with pathological fracture	0.000	0.998	0.002
Q89 Other congenital malformations, not elsewhere classified	0.002	0.998	0.000
I82.9 Embolism and thrombosis of unspecified vein	0.000	0.998	0.002
Q85.9 Phakomatosis, unspecified	0.002	0.998	0.000
Q74 Other congenital malformations of limb(s)	0.002	0.998	0.000
R72 Abnormality of white blood cells, not elsewhere classified	0.002	0.998	0.000
G60.3 Idiopathic progressive neuropathy	0.002	0.998	0.000
G60.2 Neuropathy in association with hereditary ataxia	0.002	0.998	0.000
G60.1 Refsum's disease	0.002	0.998	0.000
Q18.9 Congenital malformation of face and neck, unspecified	0.002	0.998	0.000
Q18.8 Other specified congenital malformations of face and neck	0.002	0.998	0.000
Q18.7 Microcheilia	0.002	0.998	0.000
Q18.6 Macrocheilia	0.002	0.998	0.000
Q18.5 Microstomia	0.002	0.998	0.000
Q18.4 Macrostomia	0.002	0.998	0.000
Q18.3 Webbing of neck	0.002	0.998	0.000
Q18.2 Other branchial cleft malformations	0.002	0.998	0.000
Q74.2 Other congenital malformations of lower limb(s), including pelvic girdle	0.002	0.998	0.000
S50.9 Superficial injury of forearm, unspecified	0.000	0.998	0.002
Q35-Q37 Cleft lip and cleft palate	0.002	0.998	0.000
S82.30 Fracture of lower end of tibia (closed)	0.000	0.998	0.002
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.002	0.998	0.000
M80.29 Osteoporosis of disuse with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.28 Osteoporosis of disuse with pathological fracture (Other)	0.000	0.998	0.002
M80.27 Osteoporosis of disuse with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.26 Osteoporosis of disuse with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.25 Osteoporosis of disuse with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.24 Osteoporosis of disuse with pathological fracture (Hand)	0.000	0.998	0.002
M80.23 Osteoporosis of disuse with pathological fracture (Forearm)	0.000	0.998	0.002
M80.22 Osteoporosis of disuse with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.21 Osteoporosis of disuse with pathological fracture (Shoulder region)	0.000	0.998	0.002
M80.20 Osteoporosis of disuse with pathological fracture (Multiple sites)	0.000	0.998	0.002
M80.39 Postsurgical malabsorption osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.38 Postsurgical malabsorption osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.37 Postsurgical malabsorption osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.36 Postsurgical malabsorption osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.35 Postsurgical malabsorption osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.34 Postsurgical malabsorption osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.33 Postsurgical malabsorption osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.32 Postsurgical malabsorption osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.31 Postsurgical malabsorption osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
M80.30 Postsurgical malabsorption osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.002
M80.49 Drug-induced osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.48 Drug-induced osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.47 Drug-induced osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.46 Drug-induced osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.45 Drug-induced osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.44 Drug-induced osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.43 Drug-induced osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.42 Drug-induced osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.41 Drug-induced osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
M80.40 Drug-induced osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.002
G60.9 Hereditary and idiopathic neuropathy, unspecified	0.002	0.998	0.000
K72.0 Acute and subacute hepatic failure	0.002	0.998	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.000	0.998	0.002
Q53.2 Undescended testicle, bilateral	0.002	0.998	0.000
Q53.0 Ectopic testis	0.002	0.998	0.000
Y48.5 Therapeutic gases	0.000	0.998	0.002
Y48.1 Parenteral anaesthetics	0.000	0.998	0.002
Y48.0 Inhaled anaesthetics	0.000	0.998	0.002
Q56.4 Indeterminate sex, unspecified	0.002	0.998	0.000
Q56.3 Pseudohermaphroditism, unspecified	0.002	0.998	0.000
Q56.2 Female pseudohermaphroditism, not elsewhere classified	0.002	0.998	0.000
Q56.1 Male pseudohermaphroditism, not elsewhere classified	0.002	0.998	0.000
Q56.0 Hermaphroditism, not elsewhere classified	0.002	0.998	0.000
Q65.8 Other congenital deformities of hip	0.002	0.998	0.000
Q65 Congenital deformities of hip	0.002	0.998	0.000
Y40.3 Macrolides	0.000	0.998	0.002
Y40.1 Cefalosporins and other -lactam antibiotics	0.000	0.998	0.002
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.998	0.002
M80.0 Postmenopausal osteoporosis with pathological fracture	0.000	0.998	0.002
H43.3 Other vitreous opacities	0.002	0.998	0.000
Q25.0 Patent ductus arteriosus	0.002	0.998	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.000	0.998	0.002
E27 Other disorders of adrenal gland	0.000	0.998	0.002
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)	0.002	0.998	0.000
J38.0 Paralysis of vocal cords and larynx	0.002	0.998	0.000
K83.3 Fistula of bile duct	0.000	0.998	0.002
S46.2 Injury of muscle and tendon of other parts of biceps	0.000	0.998	0.002
Y40 Systemic antibiotics	0.000	0.998	0.002
Z73 Problems related to life-management difficulty	0.002	0.998	0.000
K62.6 Ulcer of anus and rectum	0.002	0.998	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.998	0.002
Y52.8 Antivaricose drugs, including sclerosing agents	0.000	0.998	0.002
Y52.7 Peripheral vasodilators	0.000	0.998	0.002
N14.1 Nephropathy induced by other drugs, medicaments and biological substances	0.000	0.998	0.002
Q74.0 Other congenital malformations of upper limb(s), including shoulder girdle	0.002	0.998	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.000	0.998	0.002
Q30-Q34 Congenital malformations of the respiratory system	0.002	0.998	0.000
H20.9 Iridocyclitis, unspecified	0.002	0.998	0.000
N14.4 Toxic nephropathy, not elsewhere classified	0.000	0.998	0.001
N14.3 Nephropathy induced by heavy metals	0.000	0.998	0.001
N14.2 Nephropathy induced by unspecified drug, medicament or biological substance	0.000	0.998	0.001
N14.0 Analgesic nephropathy	0.000	0.998	0.001
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.998	0.002
Q37 Cleft palate with cleft lip	0.002	0.998	0.000
M80.89 Other osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.001
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.001
M80.86 Other osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.001
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.001
M80.84 Other osteoporosis with pathological fracture (Hand)	0.000	0.998	0.001
M80.83 Other osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.001
M80.82 Other osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.001
M80.81 Other osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.001
M80.80 Other osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.001
K83.2 Perforation of bile duct	0.000	0.998	0.002
K86.0 Alcohol-induced chronic pancreatitis	0.000	0.998	0.002
Q25.4 Other congenital malformations of aorta	0.002	0.998	0.000
Q83.8 Other congenital malformations of breast	0.002	0.998	0.000
Q25 Congenital malformations of great arteries	0.002	0.998	0.000
S12.90 Fracture of neck, part unspecified (closed)	0.002	0.998	0.000
N16.8 Renal tubulo-interstitial disorders in other diseases classified elsewhere	0.000	0.998	0.001
N16.5 Renal tubulo-interstitial disorders in transplant rejection	0.000	0.998	0.001
N16.4 Renal tubulo-interstitial disorders in systemic connective tissue disorders	0.000	0.998	0.001
N16.3 Renal tubulo-interstitial disorders in metabolic diseases	0.000	0.998	0.001
N16.2 Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism	0.000	0.998	0.001
N16.1 Renal tubulo-interstitial disorders in neoplastic diseases	0.000	0.998	0.001
N16.0 Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere	0.000	0.998	0.001
Q80.9 Congenital ichthyosis, unspecified	0.001	0.998	0.000
Q80.8 Other congenital ichthyosis	0.001	0.998	0.000
Q80.4 Harlequin foetus	0.001	0.998	0.000
Q80.3 Congenital bullous ichthyosiform erythroderma	0.001	0.998	0.000
Q80.2 Lamellar ichthyosis	0.001	0.998	0.000
Q80.1 X-linked ichthyosis	0.001	0.998	0.000
Q80.0 Ichthyosis vulgaris	0.001	0.998	0.000
Q81.9 Epidermolysis bullosa, unspecified	0.001	0.998	0.000
Q81.8 Other epidermolysis bullosa	0.001	0.998	0.000
Q81.2 Epidermolysis bullosa dystrophica	0.001	0.998	0.000
Q81.1 Epidermolysis bullosa letalis	0.001	0.998	0.000
Q81.0 Epidermolysis bullosa simplex	0.001	0.998	0.000
Q83.9 Congenital malformation of breast, unspecified	0.001	0.998	0.000
Q83.3 Accessory nipple	0.001	0.998	0.000
Q83.2 Absent nipple	0.001	0.998	0.000
Q83.0 Congenital absence of breast with absent nipple	0.001	0.998	0.000
Q84.9 Congenital malformation of integument, unspecified	0.001	0.998	0.000
Q84.8 Other specified congenital malformations of integument	0.001	0.998	0.000
Q84.6 Other congenital malformations of nails	0.001	0.998	0.000
Q84.5 Enlarged and hypertrophic nails	0.001	0.998	0.000
Q84.4 Congenital leukonychia	0.001	0.998	0.000
Q84.3 Anonychia	0.001	0.998	0.000
Q84.2 Other congenital malformations of hair	0.001	0.998	0.000
Q84.1 Congenital morphological disturbances of hair, not elsewhere classified	0.001	0.998	0.000
Q84.0 Congenital alopecia	0.001	0.998	0.000
Q86.8 Other congenital malformation syndromes due to known exogenous causes	0.001	0.998	0.000
Q86.2 Dysmorphism due to warfarin	0.001	0.998	0.000
Q86.1 Foetal hydantoin syndrome	0.001	0.998	0.000
Q86.0 Foetal alcohol syndrome (dysmorphic)	0.001	0.998	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.998	0.002
Q35 Cleft palate	0.002	0.998	0.000
S12.20 Fracture of other specified cervical vertebra (closed)	0.002	0.998	0.000
E27.9 Disorder of adrenal gland, unspecified	0.000	0.998	0.002
K83.0 Cholangitis	0.000	0.998	0.002
S46.0 Injury of tendon of the rotator cuff of shoulder	0.000	0.998	0.002
Y52.1 Calcium-channel blockers	0.000	0.998	0.002
Q78 Other osteochondrodysplasias	0.002	0.998	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.002	0.998	0.000
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.001
M80.58 Idiopathic osteoporosis with pathological fracture (Other)	0.000	0.998	0.001
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.001
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.001
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.001
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)	0.000	0.998	0.001
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.001
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.001
N15.8 Other specified renal tubulo-interstitial diseases	0.000	0.998	0.001
N15.0 Balkan nephropathy	0.000	0.998	0.001
Y42.0 Glucocorticoids and synthetic analogs	0.000	0.998	0.002
Y48.3 Local anaesthetics	0.000	0.998	0.002
M77.57 Other enthesopathy of foot-Ankle/Foot	0.002	0.998	0.000
K74.0 Hepatic fibrosis	0.002	0.998	0.000
K83.9 Disease of biliary tract, unspecified	0.000	0.998	0.002
Q74.9 Unspecified congenital malformation of limb(s)	0.001	0.998	0.000
Q74.8 Other specified congenital malformations of limb(s)	0.001	0.998	0.000
Q74.3 Arthrogryposis multiplex congenita	0.001	0.998	0.000
Q74.1 Congenital malformation of knee	0.001	0.998	0.000
Q89.9 Congenital malformation, unspecified	0.001	0.998	0.000
Q89.8 Other specified congenital malformations	0.001	0.998	0.000
Q89.7 Multiple congenital malformations, not elsewhere classified	0.001	0.998	0.000
Q89.4 Conjoined twins	0.001	0.998	0.000
Q89.3 Situs inversus	0.001	0.998	0.000
Q89.1 Congenital malformations of adrenal gland	0.001	0.998	0.000
Q89.0 Congenital malformations of spleen	0.001	0.998	0.000
Y49.5 Other antipsychotics and neuroleptics	0.000	0.998	0.002
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.998	0.002
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.002	0.998	0.000
M22.8 Other disorders of patella	0.000	0.998	0.002
N15.1 Renal and perinephric abscess	0.000	0.998	0.001
Q83.1 Accessory breast	0.001	0.998	0.000
N10 Acute tubulo-interstitial nephritis	0.000	0.998	0.002
Q36 Cleft lip	0.001	0.998	0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.001
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.000	0.998	0.001
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.001
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.001
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.001
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.000	0.998	0.001
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.001
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.001
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.001
K83.5 Biliary cyst	0.000	0.998	0.001
N15.9 Renal tubulo-interstitial disease, unspecified	0.000	0.998	0.001
Q25.3 Stenosis of aorta	0.001	0.998	0.000
Q53.1 Undescended testicle, unilateral	0.001	0.998	0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.000	0.998	0.002
N11 Chronic tubulo-interstitial nephritis	0.000	0.998	0.001
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.001	0.998	0.000
Q75 Other congenital malformations of skull and face bones	0.001	0.998	0.000
Q73 Reduction defects of unspecified limb	0.001	0.998	0.000
Q72 Reduction defects of lower limb	0.001	0.998	0.000
Q71 Reduction defects of upper limb	0.001	0.998	0.000
Q70 Syndactyly	0.001	0.998	0.000
Q69 Polydactyly	0.001	0.998	0.000
Q68 Other congenital musculoskeletal deformities	0.001	0.998	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.002	0.998	0.000
E27.2 Addisonian crisis	0.000	0.998	0.002
F43.2 Adjustment disorders	0.002	0.998	0.000
M17.0 Primary gonarthrosis, bilateral	0.000	0.998	0.002
Q18.0 Sinus, fistula and cyst of branchial cleft	0.001	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations