TreeWAS – Variant ID: rs10242100

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
S52.50 Fracture of lower end of radius (closed)	0.000	0.000	1.000
S52.60 Fracture of lower end of both ulna and radius (closed)	0.000	0.000	1.000
S52.6 Fracture of lower end of both ulna and radius	0.000	0.000	1.000
S52.5 Fracture of lower end of radius	0.000	0.001	0.999
S52 Fracture of forearm	0.000	0.001	0.999
M81.99 Osteoporosis, unspecified (Site unspecified)	0.000	0.002	0.998
M81.9 Osteoporosis, unspecified	0.000	0.056	0.944
S52.61 Fracture of lower end of both ulna and radius (open)	0.000	0.069	0.931
Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device	0.000	0.112	0.888
M81.90 Osteoporosis, unspecified (Multiple sites)	0.000	0.114	0.886
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.000	0.123	0.877
S52.4 Fracture of shafts of both ulna and radius	0.000	0.214	0.786
S52.8 Fracture of other parts of forearm	0.000	0.238	0.762
S52.7 Multiple fractures of forearm	0.000	0.267	0.732
S52.3 Fracture of shaft of radius	0.000	0.268	0.732
M81.96 Osteoporosis, unspecified (Lower leg)	0.000	0.282	0.718
S52.9 Fracture of forearm, part unspecified	0.000	0.284	0.716
S52.1 Fracture of upper end of radius	0.000	0.303	0.697
S52.51 Fracture of lower end of radius (open)	0.000	0.319	0.681
M81.94 Osteoporosis, unspecified (Hand)	0.000	0.323	0.677
M81.93 Osteoporosis, unspecified (Forearm)	0.000	0.323	0.677
M81.92 Osteoporosis, unspecified (Upper arm)	0.000	0.323	0.677
M81 Osteoporosis without pathological fracture	0.000	0.339	0.661
S52.0 Fracture of upper end of ulna	0.000	0.348	0.651
S52.40 Fracture of shafts of both ulna and radius (closed)	0.000	0.367	0.633
S52.80 Fracture of other parts of forearm (closed)	0.000	0.408	0.592
S82.0 Fracture of patella	0.000	0.415	0.585
S82 Fracture of lower leg, including ankle	0.000	0.416	0.584
S82.00 Fracture of patella (closed)	0.000	0.416	0.584
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.000	0.419	0.580
M81.91 Osteoporosis, unspecified (Shoulder region)	0.000	0.433	0.567
S52.41 Fracture of shafts of both ulna and radius (open)	0.000	0.437	0.563
S82.8 Fractures of other parts of lower leg	0.000	0.441	0.559
M81.98 Osteoporosis, unspecified (Other)	0.000	0.453	0.546
S52.81 Fracture of other parts of forearm (open)	0.000	0.454	0.546
S82.80 Fractures of other parts of lower leg (closed)	0.000	0.455	0.545
S52.70 Multiple fractures of forearm (closed)	0.000	0.458	0.541
S52.30 Fracture of shaft of radius (closed)	0.000	0.459	0.541
S82.5 Fracture of medial malleolus	0.000	0.459	0.541
S52.01 Fracture of upper end of ulna (open)	0.000	0.468	0.532
S52.71 Multiple fractures of forearm (open)	0.000	0.475	0.525
S52.31 Fracture of shaft of radius (open)	0.000	0.475	0.525
S52.2 Fracture of shaft of ulna	0.000	0.476	0.523
S82.1 Fracture of upper end of tibia	0.000	0.479	0.521
M81.4 Drug-induced osteoporosis	0.000	0.486	0.514
S52.91 Fracture of forearm, part unspecified (open)	0.000	0.486	0.513
S52.90 Fracture of forearm, part unspecified (closed)	0.000	0.486	0.513
S82.50 Fracture of medial malleolus (closed)	0.000	0.488	0.512
M81.2 Osteoporosis of disuse	0.000	0.492	0.508
M81.0 Postmenopausal osteoporosis	0.000	0.499	0.501
S52.11 Fracture of upper end of radius (open)	0.000	0.500	0.500
S82.6 Fracture of lateral malleolus	0.000	0.517	0.483
S52.10 Fracture of upper end of radius (closed)	0.000	0.519	0.481
M81.3 Postsurgical malabsorption osteoporosis	0.000	0.522	0.478
S82.01 Fracture of patella (open)	0.000	0.524	0.476
M81.8 Other osteoporosis	0.000	0.526	0.474
M81.6 Localised osteoporosis [Lequesne]	0.000	0.526	0.474
M81.5 Idiopathic osteoporosis	0.000	0.526	0.474
M81.1 Postoophorectomy osteoporosis	0.000	0.526	0.474
S82.10 Fracture of upper end of tibia (closed)	0.000	0.527	0.473
S82.7 Multiple fractures of lower leg	0.000	0.529	0.471
S82.4 Fracture of fibula alone	0.000	0.548	0.452
S82.3 Fracture of lower end of tibia	0.000	0.550	0.450
M81.49 Drug-induced osteoporosis (Site unspecified)	0.000	0.555	0.445
S82.9 Fracture of lower leg, part unspecified	0.000	0.581	0.419
S82.60 Fracture of lateral malleolus (closed)	0.000	0.589	0.411
S82.86 Maisonneuve's fracture	0.000	0.599	0.401
M81.20 Osteoporosis of disuse (Multiple sites)	0.000	0.601	0.399
S82.70 Multiple fractures of lower leg (closed)	0.000	0.610	0.390
M81.09 Postmenopausal osteoporosis (Site unspecified)	0.000	0.614	0.386
S82.11 Fracture of upper end of tibia (open)	0.000	0.618	0.381
S82.51 Fracture of medial malleolus (open)	0.000	0.622	0.378
M81.48 Drug-induced osteoporosis (Other)	0.000	0.631	0.368
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.000	0.631	0.368
M81.46 Drug-induced osteoporosis (Lower leg)	0.000	0.631	0.368
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.000	0.631	0.368
M81.44 Drug-induced osteoporosis (Hand)	0.000	0.631	0.368
M81.43 Drug-induced osteoporosis (Forearm)	0.000	0.631	0.368
M81.42 Drug-induced osteoporosis (Upper arm)	0.000	0.631	0.368
M81.41 Drug-induced osteoporosis (Shoulder region)	0.000	0.631	0.368
M81.29 Osteoporosis of disuse (Site unspecified)	0.000	0.635	0.364
M81.28 Osteoporosis of disuse (Other)	0.000	0.635	0.364
M81.27 Osteoporosis of disuse (Ankle and foot)	0.000	0.635	0.364
M81.26 Osteoporosis of disuse (Lower leg)	0.000	0.635	0.364
M81.25 Osteoporosis of disuse (Pelvic region and thigh)	0.000	0.635	0.364
M81.24 Osteoporosis of disuse (Hand)	0.000	0.635	0.364
M81.23 Osteoporosis of disuse (Forearm)	0.000	0.635	0.364
M81.22 Osteoporosis of disuse (Upper arm)	0.000	0.635	0.364
M81.21 Osteoporosis of disuse (Shoulder region)	0.000	0.635	0.364
S82.30 Fracture of lower end of tibia (closed)	0.000	0.638	0.362
M81.08 Postmenopausal osteoporosis (Other)	0.000	0.641	0.359
M81.07 Postmenopausal osteoporosis (Ankle and foot)	0.000	0.641	0.359
M81.06 Postmenopausal osteoporosis (Lower leg)	0.000	0.641	0.359
M81.05 Postmenopausal osteoporosis (Pelvic region and thigh)	0.000	0.641	0.359
M81.04 Postmenopausal osteoporosis (Hand)	0.000	0.641	0.359
M81.03 Postmenopausal osteoporosis (Forearm)	0.000	0.641	0.359
M81.02 Postmenopausal osteoporosis (Upper arm)	0.000	0.641	0.359
M81.01 Postmenopausal osteoporosis (Shoulder region)	0.000	0.641	0.359
M81.00 Postmenopausal osteoporosis (Multiple sites)	0.000	0.641	0.359
S82.40 Fracture of fibula alone (closed)	0.000	0.642	0.358
S82.81 Fractures of other parts of lower leg (open)	0.000	0.647	0.352
M81.30 Postsurgical malabsorption osteoporosis (Multiple sites)	0.000	0.653	0.347
S82.61 Fracture of lateral malleolus (open)	0.000	0.653	0.347
M81.39 Postsurgical malabsorption osteoporosis (Site unspecified)	0.000	0.657	0.343
M81.38 Postsurgical malabsorption osteoporosis (Other)	0.000	0.657	0.343
M81.37 Postsurgical malabsorption osteoporosis (Ankle and foot)	0.000	0.657	0.343
M81.36 Postsurgical malabsorption osteoporosis (Lower leg)	0.000	0.657	0.343
M81.35 Postsurgical malabsorption osteoporosis (Pelvic region and thigh)	0.000	0.657	0.343
M81.34 Postsurgical malabsorption osteoporosis (Hand)	0.000	0.657	0.343
M81.33 Postsurgical malabsorption osteoporosis (Forearm)	0.000	0.657	0.343
M81.32 Postsurgical malabsorption osteoporosis (Upper arm)	0.000	0.657	0.343
M81.31 Postsurgical malabsorption osteoporosis (Shoulder region)	0.000	0.657	0.343
S52.21 Fracture of shaft of ulna (open)	0.001	0.658	0.341
M81.19 Postoophorectomy osteoporosis (Site unspecified)	0.000	0.660	0.340
M81.18 Postoophorectomy osteoporosis (Other)	0.000	0.660	0.340
M81.17 Postoophorectomy osteoporosis (Ankle and foot)	0.000	0.660	0.340
M81.16 Postoophorectomy osteoporosis (Lower leg)	0.000	0.660	0.340
M81.15 Postoophorectomy osteoporosis (Pelvic region and thigh)	0.000	0.660	0.340
M81.14 Postoophorectomy osteoporosis (Hand)	0.000	0.660	0.340
M81.13 Postoophorectomy osteoporosis (Forearm)	0.000	0.660	0.340
M81.12 Postoophorectomy osteoporosis (Upper arm)	0.000	0.660	0.340
M81.11 Postoophorectomy osteoporosis (Shoulder region)	0.000	0.660	0.340
M81.10 Postoophorectomy osteoporosis (Multiple sites)	0.000	0.660	0.340
M81.59 Idiopathic osteoporosis (Site unspecified)	0.000	0.660	0.340
M81.58 Idiopathic osteoporosis (Other)	0.000	0.660	0.340
M81.57 Idiopathic osteoporosis (Ankle and foot)	0.000	0.660	0.340
M81.56 Idiopathic osteoporosis (Lower leg)	0.000	0.660	0.340
M81.55 Idiopathic osteoporosis (Pelvic region and thigh)	0.000	0.660	0.340
M81.54 Idiopathic osteoporosis (Hand)	0.000	0.660	0.340
M81.53 Idiopathic osteoporosis (Forearm)	0.000	0.660	0.340
M81.52 Idiopathic osteoporosis (Upper arm)	0.000	0.660	0.340
M81.51 Idiopathic osteoporosis (Shoulder region)	0.000	0.660	0.340
M81.50 Idiopathic osteoporosis (Multiple sites)	0.000	0.660	0.340
M81.69 Localized osteoporosis [Lequesne] (Site unspecified)	0.000	0.660	0.340
M81.68 Localized osteoporosis [Lequesne] (Other)	0.000	0.660	0.340
M81.67 Localized osteoporosis [Lequesne] (Ankle and foot)	0.000	0.660	0.340
M81.66 Localized osteoporosis [Lequesne] (Lower leg)	0.000	0.660	0.340
M81.65 Localized osteoporosis [Lequesne] (Pelvic region and thigh)	0.000	0.660	0.340
M81.64 Localized osteoporosis [Lequesne] (Hand)	0.000	0.660	0.340
M81.63 Localized osteoporosis [Lequesne] (Forearm)	0.000	0.660	0.340
M81.62 Localized osteoporosis [Lequesne] (Upper arm)	0.000	0.660	0.340
M81.61 Localized osteoporosis [Lequesne] (Shoulder region)	0.000	0.660	0.340
M81.60 Localized osteoporosis [Lequesne] (Multiple sites)	0.000	0.660	0.340
M81.89 Other osteoporosis (Site unspecified)	0.000	0.660	0.340
M81.88 Other osteoporosis (Other)	0.000	0.660	0.340
M81.87 Other osteoporosis (Ankle and foot)	0.000	0.660	0.340
M81.86 Other osteoporosis (Lower leg)	0.000	0.660	0.340
M81.85 Other osteoporosis (Pelvic region and thigh)	0.000	0.660	0.340
M81.84 Other osteoporosis (Hand)	0.000	0.660	0.340
M81.83 Other osteoporosis (Forearm)	0.000	0.660	0.340
M81.82 Other osteoporosis (Upper arm)	0.000	0.660	0.340
M81.81 Other osteoporosis (Shoulder region)	0.000	0.660	0.340
M81.80 Other osteoporosis (Multiple sites)	0.000	0.660	0.340
S82.71 Multiple fractures of lower leg (open)	0.000	0.662	0.338
S82.41 Fracture of fibula alone (open)	0.000	0.675	0.324
S82.31 Fracture of lower end of tibia (open)	0.000	0.689	0.311
S82.91 Fracture of lower leg, part unspecified (open)	0.000	0.699	0.300
S82.90 Fracture of lower leg, part unspecified (closed)	0.000	0.699	0.300
M81.40 Drug-induced osteoporosis (Multiple sites)	0.000	0.708	0.292
M80-M85 Disorders of bone density and structure	0.000	0.719	0.281
S82.2 Fracture of shaft of tibia	0.000	0.723	0.277
S52.00 Fracture of upper end of ulna (closed)	0.000	0.732	0.268
M84 Disorders of continuity of bone	0.000	0.737	0.263
S80-S89 Injuries to the knee and lower leg	0.000	0.745	0.255
M84.1 Nonunion of fracture [pseudarthrosis]	0.000	0.746	0.254
S52.20 Fracture of shaft of ulna (closed)	0.001	0.753	0.246
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.000	0.763	0.237
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.000	0.764	0.236
S89 Other and unspecified injuries of lower leg	0.000	0.786	0.214
M83 Adult osteomalacia	0.000	0.792	0.208
S86 Injury of muscle and tendon at lower leg level	0.000	0.792	0.208
M84.0 Malunion of fracture	0.000	0.793	0.207
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.000	0.803	0.197
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.000	0.807	0.193
M84.3 Stress fracture, not elsewhere classified	0.000	0.809	0.191
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.000	0.811	0.189
M84.9 Disorder of continuity of bone, unspecified	0.000	0.811	0.189
M84.2 Delayed union of fracture	0.000	0.811	0.189
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.000	0.811	0.188
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.000	0.814	0.186
S88 Traumatic amputation of lower leg	0.000	0.817	0.183
S87 Crushing injury of lower leg	0.000	0.817	0.183
S85 Injury of blood vessels at lower leg level	0.000	0.817	0.183
S84 Injury of nerves at lower leg level	0.000	0.817	0.183
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.000	0.817	0.183
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.000	0.817	0.183
S89.9 Unspecified injury of lower leg	0.000	0.821	0.179
M84.03 Malunion of fracture (Forearm)	0.000	0.825	0.175
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.000	0.826	0.173
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.000	0.827	0.173
Z47 Other orthopaedic follow-up care	0.000	0.829	0.171
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.000	0.830	0.170
M84.4 Pathological fracture, not elsewhere classified	0.000	0.833	0.167
M82 Osteoporosis in diseases classified elsewhere	0.001	0.835	0.165
S81 Open wound of lower leg	0.000	0.836	0.164
S89.8 Other specified injuries of lower leg	0.000	0.837	0.163
M84.8 Other disorders of continuity of bone	0.000	0.837	0.162
M84.05 Malunion of fracture (Pelvic region and thigh)	0.000	0.839	0.160
S82.21 Fracture of shaft of tibia (open)	0.000	0.840	0.160
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.000	0.842	0.158
M84.01 Malunion of fracture (Shoulder region)	0.000	0.844	0.156
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.000	0.845	0.155
M84.04 Malunion of fracture (Hand)	0.000	0.846	0.154
S89.7 Multiple injuries of lower leg	0.000	0.847	0.153
S89.1 Other specified injuries of lower leg	0.000	0.847	0.153
S89.0 Multiple injuries of lower leg	0.000	0.847	0.153
M83.8 Other adult osteomalacia	0.000	0.847	0.152
M83.1 Senile osteomalacia	0.000	0.847	0.152
M84.02 Malunion of fracture (Upper arm)	0.000	0.850	0.150
M83.9 Adult osteomalacia, unspecified	0.000	0.851	0.149
M83.5 Other drug-induced osteomalacia in adults	0.000	0.851	0.149
M83.4 Aluminum bone disease	0.000	0.851	0.149
M83.3 Adult osteomalacia due to malnutrition	0.000	0.851	0.149
M83.2 Adult osteomalacia due to malabsorption	0.000	0.851	0.149
M83.0 Puerperal osteomalacia	0.000	0.851	0.149
S86.0 Injury of Achilles tendon	0.000	0.851	0.149
S86.7 Injury of multiple muscles and tendons at lower leg level	0.000	0.851	0.149
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.000	0.851	0.149
M84.09 Malunion of fracture (Site unspecified)	0.000	0.851	0.149
M84.00 Malunion of fracture (Multiple sites)	0.000	0.851	0.149
S83.7 Injury to multiple structures of knee	0.000	0.854	0.146
M85 Other disorders of bone density and structure	0.000	0.859	0.141
M84.07 Malunion of fracture (Ankle and foot)	0.000	0.861	0.139
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.000	0.861	0.139
M80 Osteoporosis with pathological fracture	0.000	0.863	0.137
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.000	0.863	0.137
M84.38 Stress fracture, not elsewhere classified (Other)	0.000	0.863	0.137
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.000	0.863	0.137
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.000	0.863	0.137
M84.34 Stress fracture, not elsewhere classified (Hand)	0.000	0.863	0.137
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.000	0.863	0.137
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.000	0.863	0.137
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.000	0.863	0.137
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.000	0.863	0.137
M84.29 Delayed union of fracture (Site unspecified)	0.000	0.864	0.136
M84.28 Delayed union of fracture (Other)	0.000	0.864	0.136
M84.27 Delayed union of fracture (Ankle and foot)	0.000	0.864	0.136
M84.26 Delayed union of fracture (Lower leg)	0.000	0.864	0.136
M84.25 Delayed union of fracture (Pelvic region and thigh)	0.000	0.864	0.136
M84.24 Delayed union of fracture (Hand)	0.000	0.864	0.136
M84.23 Delayed union of fracture (Forearm)	0.000	0.864	0.136
M84.22 Delayed union of fracture (Upper arm)	0.000	0.864	0.136
M84.21 Delayed union of fracture (Shoulder region)	0.000	0.864	0.136
M84.20 Delayed union of fracture (Multiple sites)	0.000	0.864	0.136
M84.99 Disorder of continuity of bone, unspecified (Site unspecified)	0.000	0.864	0.136
M84.98 Disorder of continuity of bone, unspecified (Other)	0.000	0.864	0.136
M84.97 Disorder of continuity of bone, unspecified (Ankle and foot)	0.000	0.864	0.136
M84.96 Disorder of continuity of bone, unspecified (Lower leg)	0.000	0.864	0.136
M84.95 Disorder of continuity of bone, unspecified (Pelvic region and thigh)	0.000	0.864	0.136
M84.94 Disorder of continuity of bone, unspecified (Hand)	0.000	0.864	0.136
M84.93 Disorder of continuity of bone, unspecified (Forearm)	0.000	0.864	0.136
M84.92 Disorder of continuity of bone, unspecified (Upper arm)	0.000	0.864	0.136
M84.91 Disorder of continuity of bone, unspecified (Shoulder region)	0.000	0.864	0.136
M84.90 Disorder of continuity of bone, unspecified (Multiple sites)	0.000	0.864	0.136
S81.7 Multiple open wounds of lower leg	0.000	0.865	0.135
M84.08 Malunion of fracture (Other)	0.000	0.866	0.134
S83.3 Tear of articular cartilage of knee, current	0.000	0.867	0.133
S83.1 Dislocation of knee	0.000	0.867	0.133
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.000	0.867	0.133
S86.8 Injury of other muscles and tendons at lower leg level	0.000	0.868	0.132
S84.9 Injury of unspecified nerve at lower leg level	0.000	0.869	0.131
S84.8 Injury of other nerves at lower leg level	0.000	0.869	0.131
S84.7 Injury of multiple nerves at lower leg level	0.000	0.869	0.131
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.000	0.869	0.131
S84.1 Injury of peroneal nerve at lower leg level	0.000	0.869	0.131
S84.0 Injury of tibial nerve at lower leg level	0.000	0.869	0.131
S85.9 Injury of unspecified blood vessel at lower leg level	0.000	0.869	0.131
S85.8 Injury of other blood vessels at lower leg level	0.000	0.869	0.131
S85.7 Injury of multiple blood vessels at lower leg level	0.000	0.869	0.131
S85.5 Injury of popliteal vein	0.000	0.869	0.131
S85.4 Injury of lesser saphenous vein at lower leg level	0.000	0.869	0.131
S85.3 Injury of greater saphenous vein at lower leg level	0.000	0.869	0.131
S85.2 Injury of peroneal artery	0.000	0.869	0.131
S85.1 Injury of (anterior)(posterior) tibial artery	0.000	0.869	0.131
S85.0 Injury of popliteal artery	0.000	0.869	0.131
S87.8 Crushing injury of other and unspecified parts of lower leg	0.000	0.869	0.131
S87.0 Crushing injury of knee	0.000	0.869	0.131
S88.9 Traumatic amputation of lower leg, level unspecified	0.000	0.869	0.131
S88.1 Traumatic amputation at level between knee and ankle	0.000	0.869	0.131
S88.0 Traumatic amputation at knee level	0.000	0.869	0.131
S82.20 Fracture of shaft of tibia (closed)	0.000	0.870	0.130
M84.06 Malunion of fracture (Lower leg)	0.000	0.871	0.129
M84.45 Pathological fracture, not elsewhere classified (Pelvic region and thigh)	0.000	0.873	0.127
M84.49 Pathological fracture, not elsewhere classified (Site unspecified)	0.000	0.880	0.120
M84.47 Pathological fracture, not elsewhere classified (Ankle and foot)	0.000	0.880	0.120
M84.46 Pathological fracture, not elsewhere classified (Lower leg)	0.000	0.880	0.120
M84.44 Pathological fracture, not elsewhere classified (Hand)	0.000	0.880	0.120
M84.43 Pathological fracture, not elsewhere classified (Forearm)	0.000	0.880	0.120
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.000	0.880	0.120
M84.41 Pathological fracture, not elsewhere classified (Shoulder region)	0.000	0.880	0.120
M84.40 Pathological fracture, not elsewhere classified (Multiple sites)	0.000	0.880	0.120
M82.8 Osteoporosis in other diseases classified elsewhere	0.001	0.881	0.118
M82.0 Osteoporosis in multiple myelomatosis	0.001	0.881	0.118
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.001	0.881	0.118
M84.89 Other disorders of continuity of bone (Site unspecified)	0.000	0.883	0.117
M84.88 Other disorders of continuity of bone (Other)	0.000	0.883	0.117
M84.86 Other disorders of continuity of bone (Lower leg)	0.000	0.883	0.117
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.000	0.883	0.117
M84.84 Other disorders of continuity of bone (Hand)	0.000	0.883	0.117
M84.82 Other disorders of continuity of bone (Upper arm)	0.000	0.883	0.117
M84.81 Other disorders of continuity of bone (Shoulder region)	0.000	0.883	0.117
M84.80 Other disorders of continuity of bone (Multiple sites)	0.000	0.883	0.117
S83.0 Dislocation of patella	0.000	0.885	0.115
S81.9 Open wound of lower leg, part unspecified	0.000	0.886	0.114
M80.8 Other osteoporosis with pathological fracture	0.000	0.887	0.113
M83.80 Other adult osteomalacia (Multiple sites)	0.000	0.887	0.113
M83.12 Senile osteomalacia (Upper arm)	0.000	0.887	0.113
S83.6 Sprain and strain of other and unspecified parts of knee	0.000	0.887	0.113
M85.6 Other cyst of bone	0.000	0.889	0.111
M83.89 Other adult osteomalacia (Site unspecified)	0.000	0.890	0.109
M83.88 Other adult osteomalacia (Other)	0.000	0.890	0.109
M83.87 Other adult osteomalacia (Ankle and foot)	0.000	0.890	0.109
M83.86 Other adult osteomalacia (Lower leg)	0.000	0.890	0.109
M83.85 Other adult osteomalacia (Pelvic region and thigh)	0.000	0.890	0.109
M83.84 Other adult osteomalacia (Hand)	0.000	0.890	0.109
M83.83 Other adult osteomalacia (Forearm)	0.000	0.890	0.109
M83.82 Other adult osteomalacia (Upper arm)	0.000	0.890	0.109
M83.81 Other adult osteomalacia (Shoulder region)	0.000	0.890	0.109
M83.19 Senile osteomalacia (Site unspecified)	0.000	0.890	0.109
M83.18 Senile osteomalacia (Other)	0.000	0.890	0.109
M83.17 Senile osteomalacia (Ankle and foot)	0.000	0.890	0.109
M83.16 Senile osteomalacia (Lower leg)	0.000	0.890	0.109
M83.15 Senile osteomalacia (Pelvic region and thigh)	0.000	0.890	0.109
M83.14 Senile osteomalacia (Hand)	0.000	0.890	0.109
M83.13 Senile osteomalacia (Forearm)	0.000	0.890	0.109
M83.11 Senile osteomalacia (Shoulder region)	0.000	0.890	0.109
M83.10 Senile osteomalacia (Multiple sites)	0.000	0.890	0.109
M84.83 Other disorders of continuity of bone (Forearm)	0.000	0.892	0.108
S81.0 Open wound of knee	0.000	0.892	0.108
M83.09 Puerperal osteomalacia (Site unspecified)	0.000	0.893	0.107
M83.08 Puerperal osteomalacia (Other)	0.000	0.893	0.107
M83.07 Puerperal osteomalacia (Ankle and foot)	0.000	0.893	0.107
M83.06 Puerperal osteomalacia (Lower leg)	0.000	0.893	0.107
M83.05 Puerperal osteomalacia (Pelvic region and thigh)	0.000	0.893	0.107
M83.04 Puerperal osteomalacia (Hand)	0.000	0.893	0.107
M83.03 Puerperal osteomalacia (Forearm)	0.000	0.893	0.107
M83.02 Puerperal osteomalacia (Upper arm)	0.000	0.893	0.107
M83.01 Puerperal osteomalacia (Shoulder region)	0.000	0.893	0.107
M83.00 Puerperal osteomalacia (Multiple sites)	0.000	0.893	0.107
M83.29 Adult osteomalacia due to malabsorption (Site unspecified)	0.000	0.893	0.107
M83.28 Adult osteomalacia due to malabsorption (Other)	0.000	0.893	0.107
M83.27 Adult osteomalacia due to malabsorption (Ankle and foot)	0.000	0.893	0.107
M83.26 Adult osteomalacia due to malabsorption (Lower leg)	0.000	0.893	0.107
M83.25 Adult osteomalacia due to malabsorption (Pelvic region and thigh)	0.000	0.893	0.107
M83.24 Adult osteomalacia due to malabsorption (Hand)	0.000	0.893	0.107
M83.23 Adult osteomalacia due to malabsorption (Forearm)	0.000	0.893	0.107
M83.22 Adult osteomalacia due to malabsorption (Upper arm)	0.000	0.893	0.107
M83.21 Adult osteomalacia due to malabsorption (Shoulder region)	0.000	0.893	0.107
M83.20 Adult osteomalacia due to malabsorption (Multiple sites)	0.000	0.893	0.107
M83.39 Adult osteomalacia due to malnutrition (Site unspecified)	0.000	0.893	0.107
M83.38 Adult osteomalacia due to malnutrition (Other)	0.000	0.893	0.107
M83.37 Adult osteomalacia due to malnutrition (Ankle and foot)	0.000	0.893	0.107
M83.36 Adult osteomalacia due to malnutrition (Lower leg)	0.000	0.893	0.107
M83.35 Adult osteomalacia due to malnutrition (Pelvic region and thigh)	0.000	0.893	0.107
M83.34 Adult osteomalacia due to malnutrition (Hand)	0.000	0.893	0.107
M83.33 Adult osteomalacia due to malnutrition (Forearm)	0.000	0.893	0.107
M83.32 Adult osteomalacia due to malnutrition (Upper arm)	0.000	0.893	0.107
M83.31 Adult osteomalacia due to malnutrition (Shoulder region)	0.000	0.893	0.107
M83.30 Adult osteomalacia due to malnutrition (Multiple sites)	0.000	0.893	0.107
M83.49 Aluminium bone disease (Site unspecified)	0.000	0.893	0.107
M83.48 Aluminium bone disease (Other)	0.000	0.893	0.107
M83.47 Aluminium bone disease (Ankle and foot)	0.000	0.893	0.107
M83.46 Aluminium bone disease (Lower leg)	0.000	0.893	0.107
M83.45 Aluminium bone disease (Pelvic region and thigh)	0.000	0.893	0.107
M83.44 Aluminium bone disease (Hand)	0.000	0.893	0.107
M83.43 Aluminium bone disease (Forearm)	0.000	0.893	0.107
M83.42 Aluminium bone disease (Upper arm)	0.000	0.893	0.107
M83.41 Aluminium bone disease (Shoulder region)	0.000	0.893	0.107
M83.40 Aluminium bone disease (Multiple sites)	0.000	0.893	0.107
M83.59 Other drug-induced osteomalacia in adults (Site unspecified)	0.000	0.893	0.107
M83.58 Other drug-induced osteomalacia in adults (Other)	0.000	0.893	0.107
M83.57 Other drug-induced osteomalacia in adults (Ankle and foot)	0.000	0.893	0.107
M83.56 Other drug-induced osteomalacia in adults (Lower leg)	0.000	0.893	0.107
M83.55 Other drug-induced osteomalacia in adults (Pelvic region and thigh)	0.000	0.893	0.107
M83.54 Other drug-induced osteomalacia in adults (Hand)	0.000	0.893	0.107
M83.53 Other drug-induced osteomalacia in adults (Forearm)	0.000	0.893	0.107
M83.52 Other drug-induced osteomalacia in adults (Upper arm)	0.000	0.893	0.107
M83.51 Other drug-induced osteomalacia in adults (Shoulder region)	0.000	0.893	0.107
M83.50 Other drug-induced osteomalacia in adults (Multiple sites)	0.000	0.893	0.107
M83.99 Adult osteomalacia, unspecified (Site unspecified)	0.000	0.893	0.107
M83.98 Adult osteomalacia, unspecified (Other)	0.000	0.893	0.107
M83.97 Adult osteomalacia, unspecified (Ankle and foot)	0.000	0.893	0.107
M83.96 Adult osteomalacia, unspecified (Lower leg)	0.000	0.893	0.107
M83.95 Adult osteomalacia, unspecified (Pelvic region and thigh)	0.000	0.893	0.107
M83.94 Adult osteomalacia, unspecified (Hand)	0.000	0.893	0.107
M83.93 Adult osteomalacia, unspecified (Forearm)	0.000	0.893	0.107
M83.92 Adult osteomalacia, unspecified (Upper arm)	0.000	0.893	0.107
M83.91 Adult osteomalacia, unspecified (Shoulder region)	0.000	0.893	0.107
M83.90 Adult osteomalacia, unspecified (Multiple sites)	0.000	0.893	0.107
S86.00 Unspecified injury of Achilles tendon	0.000	0.893	0.107
Z47.9 Orthopaedic follow-up care, unspecified	0.000	0.893	0.106
S80 Superficial injury of lower leg	0.000	0.894	0.106
S50-S59 Injuries to the elbow and forearm	0.000	0.895	0.105
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.000	0.898	0.101
M85.5 Aneurysmal bone cyst	0.000	0.898	0.101
M85.4 Solitary bone cyst	0.000	0.898	0.101
M85.3 Osteitis condensans	0.000	0.898	0.101
M85.1 Skeletal fluorosis	0.000	0.898	0.101
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.000	0.899	0.101
M85.2 Hyperostosis of skull	0.000	0.900	0.099
M80.4 Drug-induced osteoporosis with pathological fracture	0.000	0.901	0.099
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.000	0.901	0.099
M80.2 Osteoporosis of disuse with pathological fracture	0.000	0.901	0.099
M85.9 Disorder of bone density and structure, unspecified	0.000	0.902	0.098
M80.88 Other osteoporosis with pathological fracture (Other)	0.000	0.904	0.096
M85.0 Fibrous dysplasia (monostotic)	0.000	0.910	0.090
M80.5 Idiopathic osteoporosis with pathological fracture	0.000	0.912	0.088
M85.65 Other cyst of bone (Pelvic region and thigh)	0.000	0.913	0.087
M84.48 Pathological fracture, not elsewhere classified (Other)	0.000	0.914	0.086
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.001	0.914	0.085
M82.09 Osteoporosis in multiple myelomatosis (Site unspecified)	0.001	0.915	0.085
M82.08 Osteoporosis in multiple myelomatosis (Other)	0.001	0.915	0.085
M82.07 Osteoporosis in multiple myelomatosis (Ankle and foot)	0.001	0.915	0.085
M82.06 Osteoporosis in multiple myelomatosis (Lower leg)	0.001	0.915	0.085
M82.05 Osteoporosis in multiple myelomatosis (Pelvic region and thigh)	0.001	0.915	0.085
M82.04 Osteoporosis in multiple myelomatosis (Hand)	0.001	0.915	0.085
M82.03 Osteoporosis in multiple myelomatosis (Forearm)	0.001	0.915	0.085
M82.02 Osteoporosis in multiple myelomatosis (Upper arm)	0.001	0.915	0.085
M82.01 Osteoporosis in multiple myelomatosis (Shoulder region)	0.001	0.915	0.085
M82.00 Osteoporosis in multiple myelomatosis (Multiple sites)	0.001	0.915	0.085
M82.89 Osteoporosis in other diseases classified elsewhere (Site unspecified)	0.001	0.915	0.085
M82.88 Osteoporosis in other diseases classified elsewhere (Other)	0.001	0.915	0.085
M82.87 Osteoporosis in other diseases classified elsewhere (Ankle and foot)	0.001	0.915	0.085
M82.86 Osteoporosis in other diseases classified elsewhere (Lower leg)	0.001	0.915	0.085
M82.85 Osteoporosis in other diseases classified elsewhere (Pelvic region and thigh)	0.001	0.915	0.085
M82.84 Osteoporosis in other diseases classified elsewhere (Hand)	0.001	0.915	0.085
M82.83 Osteoporosis in other diseases classified elsewhere (Forearm)	0.001	0.915	0.085
M82.82 Osteoporosis in other diseases classified elsewhere (Upper arm)	0.001	0.915	0.085
M82.81 Osteoporosis in other diseases classified elsewhere (Shoulder region)	0.001	0.915	0.085
M82.80 Osteoporosis in other diseases classified elsewhere (Multiple sites)	0.001	0.915	0.085
S80.1 Contusion of other and unspecified parts of lower leg	0.000	0.915	0.085
S81.8 Open wound of other parts of lower leg	0.000	0.916	0.084
M82.1 Osteoporosis in endocrine disorders	0.001	0.918	0.081
M85.67 Other cyst of bone (Ankle and foot)	0.000	0.918	0.082
M80.0 Postmenopausal osteoporosis with pathological fracture	0.000	0.918	0.082
M80.89 Other osteoporosis with pathological fracture (Site unspecified)	0.000	0.919	0.081
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)	0.000	0.919	0.081
M80.86 Other osteoporosis with pathological fracture (Lower leg)	0.000	0.919	0.081
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.919	0.081
M80.84 Other osteoporosis with pathological fracture (Hand)	0.000	0.919	0.081
M80.83 Other osteoporosis with pathological fracture (Forearm)	0.000	0.919	0.081
M80.82 Other osteoporosis with pathological fracture (Upper arm)	0.000	0.919	0.081
M80.81 Other osteoporosis with pathological fracture (Shoulder region)	0.000	0.919	0.081
M80.80 Other osteoporosis with pathological fracture (Multiple sites)	0.000	0.919	0.081
M85.69 Other cyst of bone (Site unspecified)	0.000	0.920	0.079
M85.66 Other cyst of bone (Lower leg)	0.000	0.920	0.079
M85.64 Other cyst of bone (Hand)	0.000	0.920	0.079
M85.63 Other cyst of bone (Forearm)	0.000	0.920	0.079
M85.62 Other cyst of bone (Upper arm)	0.000	0.920	0.079
M85.61 Other cyst of bone (Shoulder region)	0.000	0.920	0.079
M85.60 Other cyst of bone (Multiple sites)	0.000	0.920	0.079
M85.68 Other cyst of bone (Other)	0.000	0.921	0.079
S59 Other and unspecified injuries of forearm	0.000	0.921	0.078
S62.60 Fracture of other finger (closed)	0.000	0.922	0.078
S80.9 Superficial injury of lower leg, unspecified	0.000	0.923	0.077
S58 Traumatic amputation of forearm	0.000	0.924	0.076
S57 Crushing injury of forearm	0.000	0.924	0.076
S53 Dislocation, sprain and strain of joints and ligaments of elbow	0.000	0.925	0.075
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.000	0.926	0.074
M85.19 Skeletal fluorosis (Site unspecified)	0.000	0.927	0.073
M85.18 Skeletal fluorosis (Other)	0.000	0.927	0.073
M85.17 Skeletal fluorosis (Ankle and foot)	0.000	0.927	0.073
M85.16 Skeletal fluorosis (Lower leg)	0.000	0.927	0.073
M85.15 Skeletal fluorosis (Pelvic region and thigh)	0.000	0.927	0.073
M85.14 Skeletal fluorosis (Hand)	0.000	0.927	0.073
M85.13 Skeletal fluorosis (Forearm)	0.000	0.927	0.073
M85.12 Skeletal fluorosis (Upper arm)	0.000	0.927	0.073
M85.11 Skeletal fluorosis (Shoulder region)	0.000	0.927	0.073
M85.10 Skeletal fluorosis (Multiple sites)	0.000	0.927	0.073
M85.39 Osteitis condensans (Site unspecified)	0.000	0.927	0.073
M85.38 Osteitis condensans (Other)	0.000	0.927	0.073
M85.37 Osteitis condensans (Ankle and foot)	0.000	0.927	0.073
M85.36 Osteitis condensans (Lower leg)	0.000	0.927	0.073
M85.35 Osteitis condensans (Pelvic region and thigh)	0.000	0.927	0.073
M85.34 Osteitis condensans (Hand)	0.000	0.927	0.073
M85.33 Osteitis condensans (Forearm)	0.000	0.927	0.073
M85.32 Osteitis condensans (Upper arm)	0.000	0.927	0.073
M85.31 Osteitis condensans (Shoulder region)	0.000	0.927	0.073
M85.30 Osteitis condensans (Multiple sites)	0.000	0.927	0.073
M85.49 Solitary bone cyst (Site unspecified)	0.000	0.927	0.073
M85.48 Solitary bone cyst (Other)	0.000	0.927	0.073
M85.47 Solitary bone cyst (Ankle and foot)	0.000	0.927	0.073
M85.46 Solitary bone cyst (Lower leg)	0.000	0.927	0.073
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.000	0.927	0.073
M85.44 Solitary bone cyst (Hand)	0.000	0.927	0.073
M85.43 Solitary bone cyst (Forearm)	0.000	0.927	0.073
M85.42 Solitary bone cyst (Upper arm)	0.000	0.927	0.073
M85.41 Solitary bone cyst (Shoulder region)	0.000	0.927	0.073
M85.40 Solitary bone cyst (Multiple sites)	0.000	0.927	0.073
M85.59 Aneurysmal bone cyst (Site unspecified)	0.000	0.927	0.073
M85.58 Aneurysmal bone cyst (Other)	0.000	0.927	0.073
M85.57 Aneurysmal bone cyst (Ankle and foot)	0.000	0.927	0.073
M85.56 Aneurysmal bone cyst (Lower leg)	0.000	0.927	0.073
M85.55 Aneurysmal bone cyst (Pelvic region and thigh)	0.000	0.927	0.073
M85.54 Aneurysmal bone cyst (Hand)	0.000	0.927	0.073
M85.53 Aneurysmal bone cyst (Forearm)	0.000	0.927	0.073
M85.52 Aneurysmal bone cyst (Upper arm)	0.000	0.927	0.073
M85.51 Aneurysmal bone cyst (Shoulder region)	0.000	0.927	0.073
M85.50 Aneurysmal bone cyst (Multiple sites)	0.000	0.927	0.073
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.000	0.928	0.072

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations