TreeWAS – Variant ID: rs10899489

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
F10 Mental and behavioural disorders due to use of alcohol	0.915	0.085	0.000
F10.2 Dependence syndrome	0.913	0.087	0.000
F10.1 Harmful use	0.899	0.101	0.000
F10.3 Withdrawal state	0.896	0.104	0.000
F10.0 Acute intoxication	0.860	0.140	0.000
F10.5 Psychotic disorder	0.733	0.267	0.000
F10.9 Unspecified mental and behavioural disorder	0.673	0.327	0.000
F10.8 Other mental and behavioural disorders	0.656	0.344	0.000
F10.7 Residual and late-onset psychotic disorder	0.656	0.344	0.000
F10.4 Withdrawal state with delirium	0.631	0.369	0.000
F10.6 Amnesic syndrome	0.557	0.443	0.000
M20.1 Hallux valgus (acquired)	0.000	0.489	0.511
M20 Acquired deformities of fingers and toes	0.000	0.588	0.412
M20.2 Hallux rigidus	0.000	0.617	0.383
M20.5 Other deformities of toe(s) (acquired)	0.000	0.631	0.369
M20.6 Acquired deformity of toe(s), unspecified	0.000	0.672	0.328
M20.3 Other deformity of hallux (acquired)	0.000	0.739	0.261
M20.4 Other hammer toe(s) (acquired)	0.000	0.755	0.245
M20.0 Deformity of finger(s)	0.000	0.757	0.243
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.143	0.857	0.000
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine	0.108	0.892	0.000
F18 Mental and behavioural disorders due to use of volatile solvents	0.103	0.897	0.000
F16 Mental and behavioural disorders due to use of hallucinogens	0.103	0.897	0.000
F14 Mental and behavioural disorders due to use of cocaine	0.103	0.897	0.000
F13 Mental and behavioural disorders due to use of sedatives or hypnotics	0.103	0.897	0.000
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.102	0.898	0.000
F11 Mental and behavioural disorders due to use of opioids	0.095	0.905	0.000
F12 Mental and behavioural disorders due to use of cannabinoids	0.089	0.911	0.000
F15.1 Harmful use	0.082	0.918	0.000
F15.9 Unspecified mental and behavioural disorder	0.077	0.923	0.000
F15.8 Other mental and behavioural disorders	0.077	0.923	0.000
F15.7 Residual and late-onset psychotic disorder	0.077	0.923	0.000
F15.6 Amnesic syndrome	0.077	0.923	0.000
F15.5 Psychotic disorder	0.077	0.923	0.000
F15.4 Withdrawal state with delirium	0.077	0.923	0.000
F15.3 Withdrawal state	0.077	0.923	0.000
F15.2 Dependence syndrome	0.077	0.923	0.000
F15.0 Acute intoxication	0.077	0.923	0.000
F13.9 Unspecified mental and behavioural disorder	0.074	0.926	0.000
F13.8 Other mental and behavioural disorders	0.074	0.926	0.000
F13.7 Residual and late-onset psychotic disorder	0.074	0.926	0.000
F13.6 Amnesic syndrome	0.074	0.926	0.000
F13.5 Psychotic disorder	0.074	0.926	0.000
F13.4 Withdrawal state with delirium	0.074	0.926	0.000
F13.3 Withdrawal state	0.074	0.926	0.000
F13.2 Dependence syndrome	0.074	0.926	0.000
F13.1 Harmful use	0.074	0.926	0.000
F13.0 Acute intoxication	0.074	0.926	0.000
F14.9 Unspecified mental and behavioural disorder	0.074	0.926	0.000
F14.8 Other mental and behavioural disorders	0.074	0.926	0.000
F14.7 Residual and late-onset psychotic disorder	0.074	0.926	0.000
F14.6 Amnesic syndrome	0.074	0.926	0.000
F14.5 Psychotic disorder	0.074	0.926	0.000
F14.4 Withdrawal state with delirium	0.074	0.926	0.000
F14.3 Withdrawal state	0.074	0.926	0.000
F14.2 Dependence syndrome	0.074	0.926	0.000
F14.1 Harmful use	0.074	0.926	0.000
F14.0 Acute intoxication	0.074	0.926	0.000
F16.9 Unspecified mental and behavioural disorder	0.074	0.926	0.000
F16.8 Other mental and behavioural disorders	0.074	0.926	0.000
F16.7 Residual and late-onset psychotic disorder	0.074	0.926	0.000
F16.6 Amnesic syndrome	0.074	0.926	0.000
F16.5 Psychotic disorder	0.074	0.926	0.000
F16.4 Withdrawal state with delirium	0.074	0.926	0.000
F16.3 Withdrawal state	0.074	0.926	0.000
F16.2 Dependence syndrome	0.074	0.926	0.000
F16.1 Harmful use	0.074	0.926	0.000
F16.0 Acute intoxication	0.074	0.926	0.000
F18.9 Unspecified mental and behavioural disorder	0.074	0.926	0.000
F18.8 Other mental and behavioural disorders	0.074	0.926	0.000
F18.7 Residual and late-onset psychotic disorder	0.074	0.926	0.000
F18.6 Amnesic syndrome	0.074	0.926	0.000
F18.5 Psychotic disorder	0.074	0.926	0.000
F18.4 Withdrawal state with delirium	0.074	0.926	0.000
F18.3 Withdrawal state	0.074	0.926	0.000
F18.2 Dependence syndrome	0.074	0.926	0.000
F18.1 Harmful use	0.074	0.926	0.000
F18.0 Acute intoxication	0.074	0.926	0.000
F19.9 Unspecified mental and behavioural disorder	0.073	0.927	0.000
F19.8 Other mental and behavioural disorders	0.073	0.927	0.000
F19.7 Residual and late-onset psychotic disorder	0.073	0.927	0.000
F19.6 Amnesic syndrome	0.073	0.927	0.000
F19.5 Psychotic disorder	0.073	0.927	0.000
F19.4 Withdrawal state with delirium	0.073	0.927	0.000
F19.3 Withdrawal state	0.073	0.927	0.000
F19.0 Acute intoxication	0.073	0.927	0.000
F19.1 Harmful use	0.073	0.927	0.000
F19.2 Dependence syndrome	0.072	0.927	0.000
F11.9 Unspecified mental and behavioural disorder	0.068	0.932	0.000
F11.8 Other mental and behavioural disorders	0.068	0.932	0.000
F11.7 Residual and late-onset psychotic disorder	0.068	0.932	0.000
F11.6 Amnesic syndrome	0.068	0.932	0.000
F11.5 Psychotic disorder	0.068	0.932	0.000
F11.4 Withdrawal state with delirium	0.068	0.932	0.000
F11.3 Withdrawal state	0.068	0.932	0.000
F11.1 Harmful use	0.068	0.932	0.000
F11.0 Acute intoxication	0.068	0.932	0.000
F12.9 Unspecified mental and behavioural disorder	0.064	0.936	0.000
F12.8 Other mental and behavioural disorders	0.064	0.936	0.000
F12.7 Residual and late-onset psychotic disorder	0.064	0.936	0.000
F12.6 Amnesic syndrome	0.064	0.936	0.000
F12.5 Psychotic disorder	0.064	0.936	0.000
F12.4 Withdrawal state with delirium	0.064	0.936	0.000
F12.3 Withdrawal state	0.064	0.936	0.000
F12.0 Acute intoxication	0.064	0.936	0.000
F11.2 Dependence syndrome	0.060	0.940	0.000
F12.1 Harmful use	0.058	0.942	0.000
F12.2 Dependence syndrome	0.058	0.942	0.000
D73.0 Hyposplenism	0.035	0.965	0.000
F17 Mental and behavioural disorders due to use of tobacco	0.032	0.968	0.000
I73.9 Peripheral vascular disease, unspecified	0.000	0.969	0.031
D73 Diseases of spleen	0.030	0.970	0.000
N95.8 Other specified menopausal and perimenopausal disorders	0.029	0.971	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.026	0.974	0.000
D73.9 Disease of spleen, unspecified	0.025	0.975	0.000
D70 Agranulocytosis	0.024	0.976	0.000
F17.9 Unspecified mental and behavioural disorder	0.023	0.977	0.000
F17.8 Other mental and behavioural disorders	0.023	0.977	0.000
F17.7 Residual and late-onset psychotic disorder	0.023	0.977	0.000
F17.6 Amnesic syndrome	0.023	0.977	0.000
F17.5 Psychotic disorder	0.023	0.977	0.000
F17.4 Withdrawal state with delirium	0.023	0.977	0.000
F17.3 Withdrawal state	0.023	0.977	0.000
F17.0 Acute intoxication	0.023	0.977	0.000
D89.2 Hypergammaglobulinaemia, unspecified	0.023	0.977	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.022	0.978	0.000
D73.4 Cyst of spleen	0.022	0.978	0.000
D73.3 Abscess of spleen	0.022	0.978	0.000
D73.2 Chronic congestive splenomegaly	0.022	0.978	0.000
D73.1 Hypersplenism	0.022	0.978	0.000
D72 Other disorders of white blood cells	0.021	0.979	0.000
D73.8 Other diseases of spleen	0.021	0.979	0.000
D80-D89 Certain disorders involving the immune mechanism	0.020	0.980	0.000
D69.6 Thrombocytopenia, unspecified	0.020	0.980	0.000
D73.5 Infarction of spleen	0.020	0.980	0.000
N93.8 Other specified abnormal uterine and vaginal bleeding	0.020	0.980	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.019	0.981	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.019	0.981	0.000
D74 Methaemoglobinaemia	0.019	0.981	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.019	0.981	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.019	0.981	0.000
I73 Other peripheral vascular diseases	0.000	0.981	0.019
D72.8 Other specified disorders of white blood cells	0.018	0.982	0.000
D69 Purpura and other haemorrhagic conditions	0.018	0.982	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.018	0.982	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.016	0.984	0.000
E89.0 Postprocedural hypothyroidism	0.000	0.984	0.016
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.016	0.984	0.000
D89.3 Immune reconstitution syndrome	0.016	0.984	0.000
D89.1 Cryoglobulinaemia	0.016	0.984	0.000
I73.0 Raynaud's syndrome	0.000	0.984	0.016
D82 Immunodeficiency associated with other major defects	0.016	0.984	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.016	0.984	0.000
D72.9 Disorder of white blood cells, unspecified	0.015	0.984	0.000
D72.0 Genetic anomalies of leukocytes	0.015	0.984	0.000
D80 Immunodeficiency with predominantly antibody defects	0.015	0.984	0.000
D72.1 Eosinophilia	0.015	0.985	0.000
D55-D59 Haemolytic anaemias	0.015	0.985	0.000
D69.5 Secondary thrombocytopenia	0.015	0.985	0.000
D81 Combined immunodeficiencies	0.015	0.985	0.000
I73.8 Other specified peripheral vascular diseases	0.000	0.985	0.015
D83 Common variable immunodeficiency	0.014	0.985	0.000
D86 Sarcoidosis	0.014	0.986	0.000
D69.9 Haemorrhagic condition, unspecified	0.014	0.986	0.000
D84 Other immunodeficiencies	0.014	0.986	0.000
D74.9 Methaemoglobinaemia, unspecified	0.014	0.986	0.000
D74.8 Other methaemoglobinaemias	0.014	0.986	0.000
D74.0 Congenital methaemoglobinaemia	0.014	0.986	0.000
I73.1 Thromboangiitis obliterans [Buerger]	0.000	0.986	0.014
D69.4 Other primary thrombocytopenia	0.014	0.986	0.000
D69.2 Other nonthrombocytopenic purpura	0.013	0.987	0.000
D58 Other hereditary haemolytic anaemias	0.013	0.987	0.000
D69.8 Other specified haemorrhagic conditions	0.013	0.987	0.000
D69.1 Qualitative platelet defects	0.013	0.987	0.000
D69.0 Allergic purpura	0.013	0.987	0.000
D67 Hereditary factor IX deficiency	0.013	0.987	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.013	0.987	0.000
D82.1 Di George's syndrome	0.013	0.987	0.000
D66 Hereditary factor VIII deficiency	0.013	0.987	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.012	0.988	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.012	0.988	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.012	0.988	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.012	0.988	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.011	0.988	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.011	0.988	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.011	0.988	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.011	0.988	0.000
D82.2 Immunodeficiency with short-limbed stature	0.011	0.988	0.000
D82.0 Wiskott-Aldrich syndrome	0.011	0.988	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.011	0.989	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.011	0.989	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.011	0.989	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.011	0.989	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.011	0.989	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.011	0.989	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.011	0.989	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.011	0.989	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.011	0.989	0.000
D86.1 Sarcoidosis of lymph nodes	0.011	0.989	0.000
D57 Sickle-cell disorders	0.011	0.989	0.000
D55 Anaemia due to enzyme disorders	0.011	0.989	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.011	0.989	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.011	0.989	0.000
D81.9 Combined immunodeficiency, unspecified	0.011	0.989	0.000
D81.8 Other combined immunodeficiencies	0.011	0.989	0.000
D81.7 Major histocompatibility complex class II deficiency	0.011	0.989	0.000
D81.6 Major histocompatibility complex class I deficiency	0.011	0.989	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.011	0.989	0.000
D81.4 Nezelof's syndrome	0.011	0.989	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.011	0.989	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.011	0.989	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.011	0.989	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.011	0.989	0.000
D75 Other diseases of blood and blood-forming organs	0.010	0.989	0.001
D86.8 Sarcoidosis of other and combined sites	0.011	0.989	0.000
D83.8 Other common variable immunodeficiencies	0.010	0.989	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.010	0.989	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.010	0.989	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.010	0.989	0.000
D56 Thalassaemia	0.010	0.989	0.000
D58.0 Hereditary spherocytosis	0.010	0.990	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.010	0.990	0.000
D83.9 Common variable immunodeficiency, unspecified	0.010	0.990	0.000
D86.3 Sarcoidosis of skin	0.010	0.990	0.000
D59 Acquired haemolytic anaemia	0.010	0.990	0.000
D84.8 Other specified immunodeficiencies	0.010	0.990	0.000
D84.1 Defects in the complement system	0.010	0.990	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.010	0.990	0.000
H53.1 Subjective visual disturbances	0.010	0.990	0.000
H60.9 Otitis externa, unspecified	0.010	0.990	0.000
I12.0 Hypertensive renal disease with renal failure	0.000	0.990	0.010
D58.8 Other specified hereditary haemolytic anaemias	0.010	0.990	0.000
D58.2 Other haemoglobinopathies	0.010	0.990	0.000
D58.1 Hereditary elliptocytosis	0.010	0.990	0.000
D76.3 Other histiocytosis syndromes	0.009	0.990	0.000
F17.2 Dependence syndrome	0.010	0.990	0.000
D84.9 Immunodeficiency, unspecified	0.009	0.991	0.000
H60 Otitis externa	0.009	0.991	0.000
D75.0 Familial erythrocytosis	0.009	0.991	0.000
D86.9 Sarcoidosis, unspecified	0.009	0.991	0.000
O46.9 Antepartum haemorrhage, unspecified	0.009	0.991	0.000
M79.86 Other specified soft tissue disorders (Lower leg)	0.009	0.991	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.000	0.991	0.008
E83.1 Disorders of iron metabolism	0.000	0.991	0.008
D75.9 Disease of blood and blood-forming organs, unspecified	0.008	0.992	0.000
H60.8 Other otitis externa	0.008	0.992	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.008	0.992	0.000
D55.8 Other anaemias due to enzyme disorders	0.008	0.992	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.008	0.992	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.008	0.992	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.008	0.992	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.008	0.992	0.000
D57.8 Other sickle-cell disorders	0.008	0.992	0.000
D57.3 Sickle-cell trait	0.008	0.992	0.000
D57.2 Double heterozygous sickling disorders	0.008	0.992	0.000
D57.1 Sickle-cell anaemia without crisis	0.008	0.992	0.000
D57.0 Sickle-cell anaemia with crisis	0.008	0.992	0.000
L98.9 Disorder of skin and subcutaneous tissue, unspecified	0.000	0.992	0.008
E78.0 Pure hypercholesterolaemia	0.000	0.992	0.008
I12 Hypertensive renal disease	0.000	0.992	0.008
D56.9 Thalassaemia, unspecified	0.008	0.992	0.000
D56.8 Other thalassaemias	0.008	0.992	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.008	0.992	0.000
D56.2 Delta-beta thalassaemia	0.008	0.992	0.000
D56.1 Beta thalassaemia	0.008	0.992	0.000
D56.0 Alpha thalassaemia	0.008	0.992	0.000
D86.0 Sarcoidosis of lung	0.008	0.992	0.000
H60.4 Cholesteatoma of external ear	0.008	0.992	0.000
H60.3 Other infective otitis externa	0.008	0.992	0.000
D59.8 Other acquired haemolytic anaemias	0.007	0.992	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.007	0.992	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.007	0.992	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.007	0.992	0.000
D59.3 Haemolytic-uraemic syndrome	0.007	0.992	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.007	0.992	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.007	0.992	0.000
H21.8 Other specified disorders of iris and ciliary body	0.008	0.992	0.000
H21 Other disorders of iris and ciliary body	0.008	0.992	0.000
H60.1 Cellulitis of external ear	0.007	0.992	0.000
G35 Multiple sclerosis	0.007	0.993	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.007	0.993	0.000
E83.3 Disorders of phosphorus metabolism	0.000	0.993	0.007
H21.5 Other adhesions and disruptions of iris and ciliary body	0.007	0.993	0.000
D56.3 Thalassaemia trait	0.007	0.993	0.000
N28.8 Other specified disorders of kidney and ureter	0.000	0.993	0.007
D75.8 Other specified diseases of blood and blood-forming organs	0.007	0.993	0.000
D68 Other coagulation defects	0.007	0.993	0.000
G43.9 Migraine, unspecified	0.007	0.993	0.000
E83 Disorders of mineral metabolism	0.000	0.993	0.007
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.007	0.993	0.000
H60.0 Abscess of external ear	0.007	0.993	0.000
D59.1 Other autoimmune haemolytic anaemias	0.007	0.993	0.000
Z85.4 Personal history of malignant neoplasm of genital organs	0.007	0.993	0.000
H18 Other disorders of cornea	0.007	0.993	0.000
I12.9 Hypertensive renal disease without renal failure	0.000	0.993	0.007
E73.9 Lactose intolerance, unspecified	0.000	0.993	0.007
H60.2 Malignant otitis externa	0.007	0.993	0.000
N28.9 Disorder of kidney and ureter, unspecified	0.000	0.993	0.007
N28 Other disorders of kidney and ureter, not elsewhere classified	0.000	0.993	0.007
H60.5 Acute otitis externa, non-infective	0.006	0.993	0.000
H18.5 Hereditary corneal dystrophies	0.007	0.993	0.000
E73 Lactose intolerance	0.000	0.993	0.007
H18.9 Disorder of cornea, unspecified	0.006	0.993	0.000
H16 Keratitis	0.006	0.994	0.000
E70-E90 Metabolic disorders	0.000	0.994	0.006
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.006	0.994	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.000	0.994	0.006
E89.8 Other postprocedural endocrine and metabolic disorders	0.000	0.994	0.006
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.000	0.994	0.006
E89.5 Postprocedural testicular hypofunction	0.000	0.994	0.006
E89.4 Postprocedural ovarian failure	0.000	0.994	0.006
E89.1 Postprocedural hypoinsulinaemia	0.000	0.994	0.006
R93.1 Abnormal findings on diagnostic imaging of heart and coronary circulation	0.006	0.994	0.000
M35.3 Polymyalgia rheumatica	0.000	0.994	0.006
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.994	0.006
H21.9 Disorder of iris and ciliary body, unspecified	0.006	0.994	0.000
H16.0 Corneal ulcer	0.006	0.994	0.000
H16.9 Keratitis, unspecified	0.006	0.994	0.000
D68.1 Hereditary factor XI deficiency	0.006	0.994	0.000
D68.5 Primary Thrombophilia	0.006	0.994	0.000
D50-D53 Nutritional anaemias	0.006	0.994	0.000
N28.0 Ischaemia and infarction of kidney	0.000	0.994	0.006
H18.2 Other corneal oedema	0.006	0.994	0.000
D60-D64 Aplastic and other anaemias	0.006	0.994	0.000
D68.8 Other specified coagulation defects	0.006	0.994	0.000
D75.2 Essential thrombocytosis	0.005	0.994	0.001
H21.4 Pupillary membranes	0.006	0.994	0.000
H21.3 Cyst of iris, ciliary body and anterior chamber	0.006	0.994	0.000
H21.2 Degeneration of iris and ciliary body	0.006	0.994	0.000
H18.8 Other specified disorders of cornea	0.006	0.994	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.006	0.994	0.000
H21.0 Hyphaema	0.005	0.994	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.005	0.995	0.000
E89.2 Postprocedural hypoparathyroidism	0.000	0.995	0.005
D68.4 Acquired coagulation factor deficiency	0.005	0.995	0.000
I10 Essential (primary) hypertension	0.000	0.995	0.005
I10-I15 Hypertensive diseases	0.000	0.995	0.005
E83.9 Disorder of mineral metabolism, unspecified	0.000	0.995	0.005
E83.8 Other disorders of mineral metabolism	0.000	0.995	0.005
E83.2 Disorders of zinc metabolism	0.000	0.995	0.005
E83.0 Disorders of copper metabolism	0.000	0.995	0.005
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.005	0.995	0.000
H18.7 Other corneal deformities	0.005	0.995	0.000
H18.6 Keratoconus	0.005	0.995	0.000
H18.3 Changes in corneal membranes	0.005	0.995	0.000
H18.0 Corneal pigmentations and deposits	0.005	0.995	0.000
Z30.1 Insertion of (intra-uterine) contraceptive device	0.005	0.995	0.000
C15.9 Oesophagus, unspecified	0.005	0.995	0.000
E78.5 Hyperlipidaemia, unspecified	0.000	0.995	0.005
H18.4 Corneal degeneration	0.005	0.995	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.005	0.995	0.000
Y84.2 Radiological procedure and radiotherapy	0.005	0.995	0.000
H21.1 Other vascular disorders of iris and ciliary body	0.005	0.995	0.000
O16 Unspecified maternal hypertension	0.005	0.995	0.000
E73.8 Other lactose intolerance	0.000	0.995	0.005
E73.1 Secondary lactase deficiency	0.000	0.995	0.005
E73.0 Congenital lactase deficiency	0.000	0.995	0.005
H17 Corneal scars and opacities	0.005	0.995	0.000
E85 Amyloidosis	0.000	0.995	0.005
H15 Disorders of sclera	0.005	0.995	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.005	0.995	0.000
H16.8 Other keratitis	0.005	0.995	0.000
H16.4 Corneal neovascularisation	0.005	0.995	0.000
H16.3 Interstitial and deep keratitis	0.005	0.995	0.000
H16.1 Other superficial keratitis without conjunctivitis	0.005	0.995	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.000	0.995	0.005
E79 Disorders of purine and pyrimidine metabolism	0.000	0.995	0.005
E77 Disorders of glycoprotein metabolism	0.000	0.995	0.005
E76 Disorders of glycosaminoglycan metabolism	0.000	0.995	0.005
E72 Other disorders of amino-acid metabolism	0.000	0.995	0.005
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.000	0.995	0.005
E70 Disorders of aromatic amino-acid metabolism	0.000	0.995	0.005
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.000	0.995	0.005
G37 Other demyelinating diseases of central nervous system	0.005	0.995	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.995	0.005
H22 Disorders of iris and ciliary body in diseases classified elsewhere	0.005	0.995	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.995	0.005
E78.8 Other disorders of lipoprotein metabolism	0.000	0.995	0.005
D53 Other nutritional anaemias	0.005	0.995	0.000
E84 Cystic fibrosis	0.000	0.995	0.005
E78.3 Hyperchylomicronaemia	0.000	0.995	0.005
N28.1 Cyst of kidney, acquired	0.000	0.995	0.005
D68.0 Von Willebrand's disease	0.005	0.995	0.000
E78.6 Lipoprotein deficiency	0.000	0.995	0.004
D68.9 Coagulation defect, unspecified	0.005	0.995	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.000	0.995	0.004
N25-N29 Other disorders of kidney and ureter	0.000	0.995	0.005
H16.2 Keratoconjunctivitis	0.004	0.995	0.000
E74 Other disorders of carbohydrate metabolism	0.000	0.995	0.004
E89.3 Postprocedural hypopituitarism	0.000	0.996	0.004
H19 Disorders of sclera and cornea in diseases classified elsewhere	0.004	0.996	0.000
H18.1 Bullous keratopathy	0.004	0.996	0.000
D61 Other aplastic anaemias	0.004	0.996	0.000
E78.1 Pure hyperglyceridaemia	0.000	0.996	0.004
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.004	0.996	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.004	0.996	0.000
S06.20 Diffuse brain injury (without open intracranial wound)	0.004	0.996	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.004	0.996	0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.004	0.996	0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.004	0.996	0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.004	0.996	0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.004	0.996	0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.004	0.996	0.000
M79.8 Other specified soft tissue disorders	0.004	0.996	0.000
Z95.5 Presence of coronary angioplasty implant and graft	0.000	0.996	0.004
I22.8 Subsequent myocardial infarction of other sites	0.000	0.996	0.004
H60-H62 Diseases of external ear	0.004	0.996	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.004	0.996	0.000
O46 Antepartum haemorrhage, not elsewhere classified	0.004	0.996	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.004	0.996	0.000
E80.4 Gilbert's syndrome	0.000	0.996	0.004
M06.9 Rheumatoid arthritis, unspecified	0.004	0.996	0.000
I13 Hypertensive heart and renal disease	0.000	0.996	0.004
E85.9 Amyloidosis, unspecified	0.000	0.996	0.004
M79.80 Other specified soft tissue disorders (Multiple sites)	0.004	0.996	0.000
I15 Secondary hypertension	0.000	0.996	0.004
I22 Subsequent myocardial infarction	0.000	0.996	0.004
N26 Unspecified contracted kidney	0.000	0.996	0.004
D53.9 Nutritional anaemia, unspecified	0.004	0.996	0.000
D68.6 Other Thrombophilia	0.004	0.996	0.000
H17.8 Other corneal scars and opacities	0.004	0.996	0.000
N25 Disorders resulting from impaired renal tubular function	0.000	0.996	0.004
I11 Hypertensive heart disease	0.000	0.996	0.004
E85.3 Secondary systemic amyloidosis	0.000	0.996	0.004
M79.87 Other specified soft tissue disorders (Ankle and foot)	0.004	0.996	0.000
H15.1 Episcleritis	0.004	0.996	0.000
E85.8 Other amyloidosis	0.000	0.996	0.004
E85.2 Heredofamilial amyloidosis, unspecified	0.000	0.996	0.004
E85.1 Neuropathic heredofamilial amyloidosis	0.000	0.996	0.004
E85.0 Nonneuropathic heredofamilial amyloidosis	0.000	0.996	0.004
H17.1 Other central corneal opacity	0.004	0.996	0.000
H17.0 Adherent leukoma	0.004	0.996	0.000
E88 Other metabolic disorders	0.000	0.996	0.004
H15.9 Disorder of sclera, unspecified	0.004	0.996	0.000
H15.8 Other disorders of sclera	0.004	0.996	0.000
H15.0 Scleritis	0.004	0.996	0.000
G36 Other acute disseminated demyelination	0.004	0.996	0.000
D64.8 Other specified anaemias	0.004	0.996	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.000	0.996	0.004
E70.8 Other disorders of aromatic amino-acid metabolism	0.000	0.996	0.004
E70.3 Albinism	0.000	0.996	0.004
E70.2 Disorders of tyrosine metabolism	0.000	0.996	0.004
E70.1 Other hyperphenylalaninaemias	0.000	0.996	0.004
E70.0 Classical phenylketonuria	0.000	0.996	0.004
E71.3 Disorders of fatty-acid metabolism	0.000	0.996	0.004
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.000	0.996	0.004
E71.1 Other disorders of branched-chain amino-acid metabolism	0.000	0.996	0.004
E71.0 Maple-syrup-urine disease	0.000	0.996	0.004
E72.9 Disorder of amino-acid metabolism, unspecified	0.000	0.996	0.004
E72.8 Other specified disorders of amino-acid metabolism	0.000	0.996	0.004
E72.5 Disorders of glycine metabolism	0.000	0.996	0.004
E72.4 Disorders of ornithine metabolism	0.000	0.996	0.004
E72.3 Disorders of lysine and hydroxylysine metabolism	0.000	0.996	0.004
E72.2 Disorders of urea cycle metabolism	0.000	0.996	0.004
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.000	0.996	0.004
E72.0 Disorders of amino-acid transport	0.000	0.996	0.004
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.000	0.996	0.004
E76.8 Other disorders of glucosaminoglycan metabolism	0.000	0.996	0.004
E76.3 Mucopolysaccharidosis, unspecified	0.000	0.996	0.004
E76.2 Other mucopolysaccharidoses	0.000	0.996	0.004
E76.1 Mucopolysaccharidosis, type II	0.000	0.996	0.004
E76.0 Mucopolysaccharidosis, type I	0.000	0.996	0.004
E77.9 Disorder of glycoprotein metabolism, unspecified	0.000	0.996	0.004
E77.8 Other disorders of glycoprotein metabolism	0.000	0.996	0.004
E77.1 Defects in glycoprotein degradation	0.000	0.996	0.004
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.000	0.996	0.004
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.000	0.996	0.004
E79.8 Other disorders of purine and pyrimidine metabolism	0.000	0.996	0.004
E79.1 Lesch-Nyhan syndrome	0.000	0.996	0.004
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.000	0.996	0.004
E80.7 Disorder of bilirubin metabolism, unspecified	0.000	0.996	0.004
E80.5 Crigler-Najjar syndrome	0.000	0.996	0.004
E80.3 Defects of catalase and peroxydase	0.000	0.996	0.004
E80.2 Other porphyria	0.000	0.996	0.004
E80.1 Porphyria cutanea tarda	0.000	0.996	0.004
E80.0 Hereditary erythropoietic porphyria	0.000	0.996	0.004
H17.9 Corneal scar and opacity, unspecified	0.004	0.996	0.000
G37.5 Concentric sclerosis [Balo]	0.004	0.996	0.000
G37.4 Subacute necrotising myelitis	0.004	0.996	0.000
G37.2 Central pontine myelinolysis	0.004	0.996	0.000
G37.1 Central demyelination of corpus callosum	0.004	0.996	0.000
G37.0 Diffuse sclerosis	0.004	0.996	0.000
D64 Other anaemias	0.004	0.996	0.000
N27 Small kidney of unknown cause	0.000	0.996	0.004
H22.8 Other disorders of iris and ciliary body in diseases classified elsewhere	0.004	0.996	0.000
H22.0 Iridocyclitis in infectious and parasitic diseases classified elsewhere	0.004	0.996	0.000
E84.8 Cystic fibrosis with other manifestations	0.000	0.996	0.003
E84.1 Cystic fibrosis with intestinal manifestations	0.000	0.996	0.003
E84.0 Cystic fibrosis with pulmonary manifestations	0.000	0.996	0.003
H81.0 Meniere's disease	0.004	0.996	0.000
K66.0 Peritoneal adhesions	0.004	0.996	0.000
C15.5 Lower third of oesophagus	0.004	0.996	0.000
D53.8 Other specified nutritional anaemias	0.003	0.996	0.000
D53.2 Scorbutic anaemia	0.003	0.996	0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.003	0.996	0.000
D53.0 Protein deficiency anaemia	0.003	0.996	0.000
D75.1 Secondary polycythaemia	0.001	0.996	0.002
H22.1 Iridocyclitis in other diseases classified elsewhere	0.003	0.996	0.000
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere	0.003	0.996	0.000
S06.60 Traumatic subarachnoid haemorrhage (without open intracranial wound)	0.004	0.996	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations