TreeWAS – Variant ID: rs12272917

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.000	0.002	0.998
T36-T50 Poisoning by drugs, medicaments and biological substances	0.000	0.002	0.998
M81.99 Osteoporosis, unspecified (Site unspecified)	0.998	0.002	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.000	0.003	0.997
T39.1 4-Aminophenol derivatives	0.000	0.004	0.996
T43.2 Other and unspecified antidepressants	0.000	0.016	0.984
M81.9 Osteoporosis, unspecified	0.983	0.017	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.000	0.027	0.973
M81 Osteoporosis without pathological fracture	0.966	0.034	0.000
M80-M85 Disorders of bone density and structure	0.955	0.045	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.052	0.948
M84 Disorders of continuity of bone	0.939	0.061	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.000	0.063	0.937
T46 Poisoning by agents primarily affecting the cardiovascular system	0.000	0.085	0.915
T39.0 Salicylates	0.000	0.096	0.904
M84.1 Nonunion of fracture [pseudarthrosis]	0.898	0.102	0.000
T40.2 Other opioids	0.000	0.103	0.897
M81.98 Osteoporosis, unspecified (Other)	0.873	0.127	0.000
M82 Osteoporosis in diseases classified elsewhere	0.871	0.129	0.000
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.868	0.132	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.000	0.145	0.855
M85 Other disorders of bone density and structure	0.852	0.148	0.000
M82.1 Osteoporosis in endocrine disorders	0.812	0.188	0.000
M84.0 Malunion of fracture	0.804	0.196	0.000
M85.8 Other specified disorders of bone density and structure	0.799	0.201	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.205	0.795
T43.6 Psychostimulants with abuse potential	0.000	0.219	0.781
M81.94 Osteoporosis, unspecified (Hand)	0.779	0.220	0.000
T46.1 Calcium-channel blockers	0.000	0.225	0.775
T46.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.230	0.770
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.770	0.230	0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.765	0.235	0.000
M81.8 Other osteoporosis	0.765	0.235	0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)	0.765	0.235	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.237	0.763
M81.0 Postmenopausal osteoporosis	0.756	0.244	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.000	0.245	0.755
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.000	0.246	0.754
M84.4 Pathological fracture, not elsewhere classified	0.751	0.249	0.000
M81.96 Osteoporosis, unspecified (Lower leg)	0.743	0.257	0.000
M84.3 Stress fracture, not elsewhere classified	0.737	0.263	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.272	0.728
M81.93 Osteoporosis, unspecified (Forearm)	0.726	0.274	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.000	0.275	0.724
T40.6 Other and unspecified narcotics	0.000	0.283	0.717
M82.10 Osteoporosis in endocrine disorders (Multiple sites)	0.716	0.284	0.000
T43.9 Psychotropic drug, unspecified	0.000	0.284	0.716
T43.8 Other psychotropic drugs, not elsewhere classified	0.000	0.284	0.716
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.000	0.284	0.716
T41 Poisoning by anaesthetics and therapeutic gases	0.000	0.284	0.716
T39.4 Antirheumatics, not elsewhere classified	0.000	0.285	0.715
T39.2 Pyrazolone derivatives	0.000	0.285	0.715
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.708	0.292	0.000
M82.11 Osteoporosis in endocrine disorders (Shoulder region)	0.708	0.292	0.000
T45.0 Antiallergic and antiemetic drugs	0.000	0.294	0.706
M81.92 Osteoporosis, unspecified (Upper arm)	0.705	0.295	0.000
M81.91 Osteoporosis, unspecified (Shoulder region)	0.705	0.295	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.000	0.295	0.705
M83 Adult osteomalacia	0.697	0.303	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.000	0.306	0.694
M81.6 Localised osteoporosis [Lequesne]	0.692	0.307	0.000
M81.5 Idiopathic osteoporosis	0.692	0.307	0.000
M81.1 Postoophorectomy osteoporosis	0.692	0.307	0.000
M84.8 Other disorders of continuity of bone	0.689	0.311	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.688	0.312	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.000	0.315	0.684
M84.04 Malunion of fracture (Hand)	0.676	0.324	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.675	0.325	0.000
M84.9 Disorder of continuity of bone, unspecified	0.673	0.326	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.000	0.328	0.672
T40.8 Lysergide [LSD]	0.000	0.328	0.672
T40.7 Cannabis (derivatives)	0.000	0.328	0.672
T40.5 Cocaine	0.000	0.328	0.672
T40.3 Methadone	0.000	0.328	0.672
T40.1 Heroin	0.000	0.328	0.672
T40.0 Opium	0.000	0.328	0.672
T46.3 Coronary vasodilators, not elsewhere classified	0.000	0.333	0.667
M84.2 Delayed union of fracture	0.666	0.334	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.659	0.341	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.344	0.656
T46.8 Antivaricose drugs, including sclerosing agents	0.000	0.344	0.656
T46.7 Peripheral vasodilators	0.000	0.344	0.656
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.344	0.656
T45.5 Anticoagulants	0.000	0.345	0.655
T45.1 Antineoplastic and immunosuppressive drugs	0.000	0.346	0.654
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.000	0.347	0.653
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.653	0.347	0.000
T36 Poisoning by systemic antibiotics	0.000	0.349	0.651
T46.4 Angiotensin-converting-enzyme inhibitors	0.000	0.352	0.648
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.644	0.356	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.644	0.356	0.000
M84.02 Malunion of fracture (Upper arm)	0.641	0.359	0.000
M85.9 Disorder of bone density and structure, unspecified	0.639	0.361	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.635	0.365	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.000	0.370	0.630
M82.8 Osteoporosis in other diseases classified elsewhere	0.625	0.375	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.625	0.375	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.625	0.375	0.000
M81.80 Other osteoporosis (Multiple sites)	0.621	0.379	0.000
M81.2 Osteoporosis of disuse	0.616	0.384	0.000
T38.1 Thyroid hormones and substitutes	0.000	0.387	0.613
T45.9 Primarily systemic and haematological agent, unspecified	0.000	0.387	0.613
T45.8 Other primarily systemic and haematological agents	0.000	0.387	0.613
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.000	0.387	0.613
T45.6 Fibrinolysis-affecting drugs	0.000	0.387	0.613
T45.4 Iron and its compounds	0.000	0.387	0.613
T45.3 Enzymes, not elsewhere classified	0.000	0.387	0.613
T45.2 Vitamins, not elsewhere classified	0.000	0.389	0.611
M85.5 Aneurysmal bone cyst	0.611	0.389	0.000
M85.4 Solitary bone cyst	0.611	0.389	0.000
M85.3 Osteitis condensans	0.611	0.389	0.000
M85.1 Skeletal fluorosis	0.611	0.389	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.000	0.390	0.610
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.000	0.392	0.608
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.000	0.392	0.608
M81.09 Postmenopausal osteoporosis (Site unspecified)	0.605	0.395	0.000
M85.6 Other cyst of bone	0.603	0.397	0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.602	0.398	0.000
M84.06 Malunion of fracture (Lower leg)	0.597	0.403	0.000
M85.2 Hyperostosis of skull	0.597	0.403	0.000
M80 Osteoporosis with pathological fracture	0.595	0.405	0.000
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.591	0.409	0.000
T40.4 Other synthetic narcotics	0.000	0.414	0.585
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.000	0.416	0.584
M82.19 Osteoporosis in endocrine disorders (Site unspecified)	0.582	0.418	0.000
M82.18 Osteoporosis in endocrine disorders (Other)	0.582	0.418	0.000
M82.17 Osteoporosis in endocrine disorders (Ankle and foot)	0.582	0.418	0.000
M82.16 Osteoporosis in endocrine disorders (Lower leg)	0.582	0.418	0.000
M82.15 Osteoporosis in endocrine disorders (Pelvic region and thigh)	0.582	0.418	0.000
M82.14 Osteoporosis in endocrine disorders (Hand)	0.582	0.418	0.000
M82.13 Osteoporosis in endocrine disorders (Forearm)	0.582	0.418	0.000
M82.12 Osteoporosis in endocrine disorders (Upper arm)	0.582	0.418	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.000	0.419	0.581
M81.4 Drug-induced osteoporosis	0.580	0.420	0.000
M84.09 Malunion of fracture (Site unspecified)	0.576	0.423	0.000
M84.08 Malunion of fracture (Other)	0.576	0.423	0.000
M84.00 Malunion of fracture (Multiple sites)	0.576	0.423	0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.575	0.425	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.573	0.427	0.000
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.573	0.427	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.573	0.427	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.573	0.427	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.573	0.427	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.573	0.427	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.428	0.572
M84.45 Pathological fracture, not elsewhere classified (Pelvic region and thigh)	0.571	0.429	0.000
M84.01 Malunion of fracture (Shoulder region)	0.568	0.432	0.000
M84.48 Pathological fracture, not elsewhere classified (Other)	0.559	0.441	0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.559	0.441	0.000
M81.89 Other osteoporosis (Site unspecified)	0.549	0.451	0.000
M81.88 Other osteoporosis (Other)	0.549	0.451	0.000
M81.87 Other osteoporosis (Ankle and foot)	0.549	0.451	0.000
M81.86 Other osteoporosis (Lower leg)	0.549	0.451	0.000
M81.85 Other osteoporosis (Pelvic region and thigh)	0.549	0.451	0.000
M81.84 Other osteoporosis (Hand)	0.549	0.451	0.000
M81.83 Other osteoporosis (Forearm)	0.549	0.451	0.000
M81.82 Other osteoporosis (Upper arm)	0.549	0.451	0.000
M81.81 Other osteoporosis (Shoulder region)	0.549	0.451	0.000
M81.08 Postmenopausal osteoporosis (Other)	0.542	0.458	0.000
M81.07 Postmenopausal osteoporosis (Ankle and foot)	0.542	0.458	0.000
M81.06 Postmenopausal osteoporosis (Lower leg)	0.542	0.458	0.000
M81.05 Postmenopausal osteoporosis (Pelvic region and thigh)	0.542	0.458	0.000
M81.04 Postmenopausal osteoporosis (Hand)	0.542	0.458	0.000
M81.03 Postmenopausal osteoporosis (Forearm)	0.542	0.458	0.000
M81.02 Postmenopausal osteoporosis (Upper arm)	0.542	0.458	0.000
M81.01 Postmenopausal osteoporosis (Shoulder region)	0.542	0.458	0.000
M81.00 Postmenopausal osteoporosis (Multiple sites)	0.542	0.458	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.000	0.458	0.541
T37.5 Antiviral drugs	0.000	0.458	0.541
T37.4 Anthelminthics	0.000	0.458	0.541
T37.3 Other antiprotozoal drugs	0.000	0.458	0.541
T37.2 Antimalarials and drugs acting on other blood protozoa	0.000	0.458	0.541
T37.1 Antimycobacterial drugs	0.000	0.458	0.541
T37.0 Sulphonamides	0.000	0.458	0.541
T47.1 Other antacids and anti-gastric-secretion drugs	0.000	0.461	0.539
M84.49 Pathological fracture, not elsewhere classified (Site unspecified)	0.538	0.461	0.000
M84.47 Pathological fracture, not elsewhere classified (Ankle and foot)	0.538	0.461	0.000
M84.46 Pathological fracture, not elsewhere classified (Lower leg)	0.538	0.461	0.000
M84.44 Pathological fracture, not elsewhere classified (Hand)	0.538	0.461	0.000
M84.43 Pathological fracture, not elsewhere classified (Forearm)	0.538	0.461	0.000
M84.41 Pathological fracture, not elsewhere classified (Shoulder region)	0.538	0.461	0.000
M84.40 Pathological fracture, not elsewhere classified (Multiple sites)	0.538	0.461	0.000
M84.05 Malunion of fracture (Pelvic region and thigh)	0.536	0.464	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.000	0.472	0.528
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.528	0.472	0.000
M84.38 Stress fracture, not elsewhere classified (Other)	0.528	0.472	0.000
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.528	0.472	0.000
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.528	0.472	0.000
M84.34 Stress fracture, not elsewhere classified (Hand)	0.528	0.472	0.000
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.528	0.472	0.000
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.528	0.472	0.000
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.528	0.472	0.000
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.528	0.472	0.000
T38.9 Other and unspecified hormone antagonists	0.000	0.478	0.522
T38.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.478	0.522
T38.7 Androgens and anabolic congeners	0.000	0.478	0.522
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.000	0.478	0.522
T38.4 Oral contraceptives	0.000	0.478	0.522
T38.2 Antithyroid drugs	0.000	0.478	0.522
T38.0 Glucocorticoids and synthetic analogues	0.000	0.478	0.522
M84.83 Other disorders of continuity of bone (Forearm)	0.521	0.479	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.000	0.480	0.519
T48.5 Anti-common-cold drugs	0.000	0.480	0.519
T48.4 Expectorants	0.000	0.480	0.519
T48.3 Antitussives	0.000	0.480	0.519
T48.2 Other and unspecified agents primarily acting on muscles	0.000	0.480	0.519
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.000	0.480	0.519
T48.0 Oxytocic drugs	0.000	0.480	0.519
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.518	0.482	0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.516	0.484	0.000
T41.5 Therapeutic gases	0.000	0.487	0.513
T41.4 Anaesthetic, unspecified	0.000	0.487	0.513
T41.3 Local anaesthetics	0.000	0.487	0.513
T41.2 Other and unspecified general anaesthetics	0.000	0.487	0.513
T41.1 Intravenous anaesthetics	0.000	0.487	0.513
T41.0 Inhaled anaesthetics	0.000	0.487	0.513
T49.9 Topical agent, unspecified	0.000	0.487	0.513
T49.8 Other topical agents	0.000	0.487	0.513
T49.7 Dental drugs, topically applied	0.000	0.487	0.513
T49.6 Otorhinolaryngological drugs and preparations	0.000	0.487	0.513
T49.5 Ophthalmological drugs and preparations	0.000	0.487	0.513
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.000	0.487	0.513
T49.3 Emollients, demulcents and protectants	0.000	0.487	0.513
T49.2 Local astringents and local detergents	0.000	0.487	0.513
T49.1 Antipruritics	0.000	0.487	0.513
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.000	0.487	0.513
M83.1 Senile osteomalacia	0.512	0.488	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.507	0.493	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.000	0.495	0.505
T47.8 Other agents primarily affecting the gastro-intestinal system	0.000	0.495	0.505
T47.7 Emetics	0.000	0.495	0.505
T47.6 Antidiarrhoeal drugs	0.000	0.495	0.505
T47.5 Digestants	0.000	0.495	0.505
T47.4 Other laxatives	0.000	0.495	0.505
T47.3 Saline and osmotic laxatives	0.000	0.495	0.505
T47.2 Stimulant laxatives	0.000	0.495	0.505
M85.0 Fibrous dysplasia (monostotic)	0.502	0.498	0.000
M83.9 Adult osteomalacia, unspecified	0.500	0.500	0.000
M83.8 Other adult osteomalacia	0.500	0.500	0.000
M83.5 Other drug-induced osteomalacia in adults	0.500	0.500	0.000
M83.4 Aluminum bone disease	0.500	0.500	0.000
M83.3 Adult osteomalacia due to malnutrition	0.500	0.500	0.000
M83.2 Adult osteomalacia due to malabsorption	0.500	0.500	0.000
M83.0 Puerperal osteomalacia	0.500	0.500	0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.499	0.501	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.000	0.502	0.498
T42.2 Succinimides and oxazolidinediones	0.000	0.502	0.498
M81.19 Postoophorectomy osteoporosis (Site unspecified)	0.496	0.503	0.000
M81.18 Postoophorectomy osteoporosis (Other)	0.496	0.503	0.000
M81.17 Postoophorectomy osteoporosis (Ankle and foot)	0.496	0.503	0.000
M81.16 Postoophorectomy osteoporosis (Lower leg)	0.496	0.503	0.000
M81.15 Postoophorectomy osteoporosis (Pelvic region and thigh)	0.496	0.503	0.000
M81.14 Postoophorectomy osteoporosis (Hand)	0.496	0.503	0.000
M81.13 Postoophorectomy osteoporosis (Forearm)	0.496	0.503	0.000
M81.12 Postoophorectomy osteoporosis (Upper arm)	0.496	0.503	0.000
M81.11 Postoophorectomy osteoporosis (Shoulder region)	0.496	0.503	0.000
M81.10 Postoophorectomy osteoporosis (Multiple sites)	0.496	0.503	0.000
M81.59 Idiopathic osteoporosis (Site unspecified)	0.496	0.503	0.000
M81.58 Idiopathic osteoporosis (Other)	0.496	0.503	0.000
M81.57 Idiopathic osteoporosis (Ankle and foot)	0.496	0.503	0.000
M81.56 Idiopathic osteoporosis (Lower leg)	0.496	0.503	0.000
M81.55 Idiopathic osteoporosis (Pelvic region and thigh)	0.496	0.503	0.000
M81.54 Idiopathic osteoporosis (Hand)	0.496	0.503	0.000
M81.53 Idiopathic osteoporosis (Forearm)	0.496	0.503	0.000
M81.52 Idiopathic osteoporosis (Upper arm)	0.496	0.503	0.000
M81.51 Idiopathic osteoporosis (Shoulder region)	0.496	0.503	0.000
M81.50 Idiopathic osteoporosis (Multiple sites)	0.496	0.503	0.000
M81.69 Localized osteoporosis [Lequesne] (Site unspecified)	0.496	0.503	0.000
M81.68 Localized osteoporosis [Lequesne] (Other)	0.496	0.503	0.000
M81.67 Localized osteoporosis [Lequesne] (Ankle and foot)	0.496	0.503	0.000
M81.66 Localized osteoporosis [Lequesne] (Lower leg)	0.496	0.503	0.000
M81.65 Localized osteoporosis [Lequesne] (Pelvic region and thigh)	0.496	0.503	0.000
M81.64 Localized osteoporosis [Lequesne] (Hand)	0.496	0.503	0.000
M81.63 Localized osteoporosis [Lequesne] (Forearm)	0.496	0.503	0.000
M81.62 Localized osteoporosis [Lequesne] (Upper arm)	0.496	0.503	0.000
M81.61 Localized osteoporosis [Lequesne] (Shoulder region)	0.496	0.503	0.000
M81.60 Localized osteoporosis [Lequesne] (Multiple sites)	0.496	0.503	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.000	0.505	0.495
M84.89 Other disorders of continuity of bone (Site unspecified)	0.494	0.506	0.000
M84.88 Other disorders of continuity of bone (Other)	0.494	0.506	0.000
M84.86 Other disorders of continuity of bone (Lower leg)	0.494	0.506	0.000
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.494	0.506	0.000
M84.84 Other disorders of continuity of bone (Hand)	0.494	0.506	0.000
M84.82 Other disorders of continuity of bone (Upper arm)	0.494	0.506	0.000
M84.81 Other disorders of continuity of bone (Shoulder region)	0.494	0.506	0.000
M84.80 Other disorders of continuity of bone (Multiple sites)	0.494	0.506	0.000
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.487	0.513	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.000	0.514	0.486
T42.0 Hydantoin derivatives	0.000	0.515	0.485
T42.1 Iminostilbenes	0.000	0.516	0.484
M81.39 Postsurgical malabsorption osteoporosis (Site unspecified)	0.484	0.516	0.000
M81.38 Postsurgical malabsorption osteoporosis (Other)	0.484	0.516	0.000
M81.37 Postsurgical malabsorption osteoporosis (Ankle and foot)	0.484	0.516	0.000
M81.36 Postsurgical malabsorption osteoporosis (Lower leg)	0.484	0.516	0.000
M81.35 Postsurgical malabsorption osteoporosis (Pelvic region and thigh)	0.484	0.516	0.000
M81.34 Postsurgical malabsorption osteoporosis (Hand)	0.484	0.516	0.000
M81.33 Postsurgical malabsorption osteoporosis (Forearm)	0.484	0.516	0.000
M81.32 Postsurgical malabsorption osteoporosis (Upper arm)	0.484	0.516	0.000
M81.31 Postsurgical malabsorption osteoporosis (Shoulder region)	0.484	0.516	0.000
M84.99 Disorder of continuity of bone, unspecified (Site unspecified)	0.483	0.517	0.000
M84.98 Disorder of continuity of bone, unspecified (Other)	0.483	0.517	0.000
M84.97 Disorder of continuity of bone, unspecified (Ankle and foot)	0.483	0.517	0.000
M84.96 Disorder of continuity of bone, unspecified (Lower leg)	0.483	0.517	0.000
M84.95 Disorder of continuity of bone, unspecified (Pelvic region and thigh)	0.483	0.517	0.000
M84.94 Disorder of continuity of bone, unspecified (Hand)	0.483	0.517	0.000
M84.93 Disorder of continuity of bone, unspecified (Forearm)	0.483	0.517	0.000
M84.92 Disorder of continuity of bone, unspecified (Upper arm)	0.483	0.517	0.000
M84.91 Disorder of continuity of bone, unspecified (Shoulder region)	0.483	0.517	0.000
M84.90 Disorder of continuity of bone, unspecified (Multiple sites)	0.483	0.517	0.000
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.481	0.519	0.000
M84.29 Delayed union of fracture (Site unspecified)	0.477	0.523	0.000
M84.28 Delayed union of fracture (Other)	0.477	0.523	0.000
M84.27 Delayed union of fracture (Ankle and foot)	0.477	0.523	0.000
M84.25 Delayed union of fracture (Pelvic region and thigh)	0.477	0.523	0.000
M84.24 Delayed union of fracture (Hand)	0.477	0.523	0.000
M84.23 Delayed union of fracture (Forearm)	0.477	0.523	0.000
M84.22 Delayed union of fracture (Upper arm)	0.477	0.523	0.000
M84.21 Delayed union of fracture (Shoulder region)	0.477	0.523	0.000
M84.20 Delayed union of fracture (Multiple sites)	0.477	0.523	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.000	0.525	0.475
M84.26 Delayed union of fracture (Lower leg)	0.469	0.530	0.000
T36.9 Systemic antibiotic, unspecified	0.000	0.533	0.467
T36.8 Other systemic antibiotics	0.000	0.533	0.467
T36.7 Antifungal antibiotics, systemically used	0.000	0.533	0.467
T36.6 Rifamycins	0.000	0.533	0.467
T36.5 Aminoglycosides	0.000	0.533	0.467
T36.4 Tetracyclines	0.000	0.533	0.467
T36.2 Chloramphenicol group	0.000	0.533	0.467
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.000	0.533	0.467
M81.30 Postsurgical malabsorption osteoporosis (Multiple sites)	0.466	0.534	0.000
M84.03 Malunion of fracture (Forearm)	0.461	0.539	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.000	0.541	0.459
M85.98 Disorder of bone density and structure, unspecified (Other)	0.458	0.541	0.000
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.458	0.541	0.000
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.458	0.541	0.000
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.458	0.541	0.000
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.458	0.541	0.000
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.458	0.541	0.000
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.458	0.541	0.000
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.458	0.541	0.000
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.458	0.541	0.000
M85.64 Other cyst of bone (Hand)	0.455	0.545	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.000	0.548	0.452
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.000	0.548	0.452
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.000	0.548	0.452
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.000	0.548	0.452
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.000	0.548	0.452
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.000	0.548	0.452
T44.1 Other parasympathomimetics [cholinergics]	0.000	0.548	0.452
T44.0 Anticholinesterase agents	0.000	0.548	0.452
M85.66 Other cyst of bone (Lower leg)	0.451	0.549	0.000
T47.0 Histamine H(2)-receptor antagonists	0.000	0.549	0.451
M82.09 Osteoporosis in multiple myelomatosis (Site unspecified)	0.448	0.552	0.000
M82.08 Osteoporosis in multiple myelomatosis (Other)	0.448	0.552	0.000
M82.07 Osteoporosis in multiple myelomatosis (Ankle and foot)	0.448	0.552	0.000
M82.06 Osteoporosis in multiple myelomatosis (Lower leg)	0.448	0.552	0.000
M82.05 Osteoporosis in multiple myelomatosis (Pelvic region and thigh)	0.448	0.552	0.000
M82.04 Osteoporosis in multiple myelomatosis (Hand)	0.448	0.552	0.000
M82.03 Osteoporosis in multiple myelomatosis (Forearm)	0.448	0.552	0.000
M82.02 Osteoporosis in multiple myelomatosis (Upper arm)	0.448	0.552	0.000
M82.01 Osteoporosis in multiple myelomatosis (Shoulder region)	0.448	0.552	0.000
M82.00 Osteoporosis in multiple myelomatosis (Multiple sites)	0.448	0.552	0.000
M82.89 Osteoporosis in other diseases classified elsewhere (Site unspecified)	0.448	0.552	0.000
M82.88 Osteoporosis in other diseases classified elsewhere (Other)	0.448	0.552	0.000
M82.87 Osteoporosis in other diseases classified elsewhere (Ankle and foot)	0.448	0.552	0.000
M82.86 Osteoporosis in other diseases classified elsewhere (Lower leg)	0.448	0.552	0.000
M82.85 Osteoporosis in other diseases classified elsewhere (Pelvic region and thigh)	0.448	0.552	0.000
M82.84 Osteoporosis in other diseases classified elsewhere (Hand)	0.448	0.552	0.000
M82.83 Osteoporosis in other diseases classified elsewhere (Forearm)	0.448	0.552	0.000
M82.82 Osteoporosis in other diseases classified elsewhere (Upper arm)	0.448	0.552	0.000
M82.81 Osteoporosis in other diseases classified elsewhere (Shoulder region)	0.448	0.552	0.000
M82.80 Osteoporosis in other diseases classified elsewhere (Multiple sites)	0.448	0.552	0.000
T36.0 Penicillins	0.000	0.553	0.446
T42.3 Barbiturates	0.000	0.557	0.443
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.443	0.557	0.000
M81.29 Osteoporosis of disuse (Site unspecified)	0.441	0.558	0.000
M81.28 Osteoporosis of disuse (Other)	0.441	0.558	0.000
M81.27 Osteoporosis of disuse (Ankle and foot)	0.441	0.558	0.000
M81.26 Osteoporosis of disuse (Lower leg)	0.441	0.558	0.000
M81.25 Osteoporosis of disuse (Pelvic region and thigh)	0.441	0.558	0.000
M81.24 Osteoporosis of disuse (Hand)	0.441	0.558	0.000
M81.23 Osteoporosis of disuse (Forearm)	0.441	0.558	0.000
M81.22 Osteoporosis of disuse (Upper arm)	0.441	0.558	0.000
M81.21 Osteoporosis of disuse (Shoulder region)	0.441	0.558	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.441	0.559	0.000
M85.19 Skeletal fluorosis (Site unspecified)	0.438	0.562	0.000
M85.18 Skeletal fluorosis (Other)	0.438	0.562	0.000
M85.17 Skeletal fluorosis (Ankle and foot)	0.438	0.562	0.000
M85.16 Skeletal fluorosis (Lower leg)	0.438	0.562	0.000
M85.15 Skeletal fluorosis (Pelvic region and thigh)	0.438	0.562	0.000
M85.14 Skeletal fluorosis (Hand)	0.438	0.562	0.000
M85.13 Skeletal fluorosis (Forearm)	0.438	0.562	0.000
M85.12 Skeletal fluorosis (Upper arm)	0.438	0.562	0.000
M85.11 Skeletal fluorosis (Shoulder region)	0.438	0.562	0.000
M85.10 Skeletal fluorosis (Multiple sites)	0.438	0.562	0.000
M85.39 Osteitis condensans (Site unspecified)	0.438	0.562	0.000
M85.38 Osteitis condensans (Other)	0.438	0.562	0.000
M85.37 Osteitis condensans (Ankle and foot)	0.438	0.562	0.000
M85.36 Osteitis condensans (Lower leg)	0.438	0.562	0.000
M85.35 Osteitis condensans (Pelvic region and thigh)	0.438	0.562	0.000
M85.34 Osteitis condensans (Hand)	0.438	0.562	0.000
M85.33 Osteitis condensans (Forearm)	0.438	0.562	0.000
M85.32 Osteitis condensans (Upper arm)	0.438	0.562	0.000
M85.31 Osteitis condensans (Shoulder region)	0.438	0.562	0.000
M85.30 Osteitis condensans (Multiple sites)	0.438	0.562	0.000
M85.49 Solitary bone cyst (Site unspecified)	0.438	0.562	0.000
M85.48 Solitary bone cyst (Other)	0.438	0.562	0.000
M85.47 Solitary bone cyst (Ankle and foot)	0.438	0.562	0.000
M85.46 Solitary bone cyst (Lower leg)	0.438	0.562	0.000
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.438	0.562	0.000
M85.44 Solitary bone cyst (Hand)	0.438	0.562	0.000
M85.43 Solitary bone cyst (Forearm)	0.438	0.562	0.000
M85.42 Solitary bone cyst (Upper arm)	0.438	0.562	0.000
M85.41 Solitary bone cyst (Shoulder region)	0.438	0.562	0.000
M85.40 Solitary bone cyst (Multiple sites)	0.438	0.562	0.000
M85.59 Aneurysmal bone cyst (Site unspecified)	0.438	0.562	0.000
M85.58 Aneurysmal bone cyst (Other)	0.438	0.562	0.000
M85.57 Aneurysmal bone cyst (Ankle and foot)	0.438	0.562	0.000
M85.56 Aneurysmal bone cyst (Lower leg)	0.438	0.562	0.000
M85.55 Aneurysmal bone cyst (Pelvic region and thigh)	0.438	0.562	0.000
M85.54 Aneurysmal bone cyst (Hand)	0.438	0.562	0.000
M85.53 Aneurysmal bone cyst (Forearm)	0.438	0.562	0.000
M85.52 Aneurysmal bone cyst (Upper arm)	0.438	0.562	0.000
M85.51 Aneurysmal bone cyst (Shoulder region)	0.438	0.562	0.000
M85.50 Aneurysmal bone cyst (Multiple sites)	0.438	0.562	0.000
M85.65 Other cyst of bone (Pelvic region and thigh)	0.434	0.566	0.000
M85.69 Other cyst of bone (Site unspecified)	0.432	0.568	0.000
M85.63 Other cyst of bone (Forearm)	0.432	0.568	0.000
M85.62 Other cyst of bone (Upper arm)	0.432	0.568	0.000
M85.61 Other cyst of bone (Shoulder region)	0.432	0.568	0.000
M85.60 Other cyst of bone (Multiple sites)	0.432	0.568	0.000
T38.5 Other oestrogens and progestogens	0.000	0.568	0.431
M85.29 Hyperostosis of skull-Site unspec	0.428	0.572	0.000
M85.28 Hyperostosis of skull-Other	0.428	0.572	0.000
M85.27 Hyperostosis of skull-Ankle/Foot	0.428	0.572	0.000
M85.26 Hyperostosis of skull-Lower Leg	0.428	0.572	0.000
M85.25 Hyperostosis of skull-Pelvic/Thigh	0.428	0.572	0.000
M85.24 Hyperostosis of skull-Hand	0.428	0.572	0.000
M85.23 Hyperostosis of skull-Forearm	0.428	0.572	0.000
M85.22 Hyperostosis of skull-Upper arm	0.428	0.572	0.000
M85.21 Hyperostosis of skull-Shldr region	0.428	0.572	0.000
T36.3 Macrolides	0.000	0.573	0.427
M80.4 Drug-induced osteoporosis with pathological fracture	0.427	0.573	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.427	0.573	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.427	0.573	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.426	0.574	0.000
T50.7 Analeptics and opioid receptor antagonists	0.000	0.581	0.419
T50.6 Antidotes and chelating agents, not elsewhere classified	0.000	0.581	0.419
T50.5 Appetite depressants	0.000	0.581	0.419
T50.4 Drugs affecting uric acid metabolism	0.000	0.581	0.419
T50.3 Electrolytic, caloric and water-balance agents	0.000	0.581	0.419
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.000	0.581	0.419
T50.1 Loop [high-ceiling] diuretics	0.000	0.581	0.419
T50.0 Mineralocorticoids and their antagonists	0.000	0.581	0.419
M81.48 Drug-induced osteoporosis (Other)	0.416	0.584	0.000
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.416	0.584	0.000
M81.46 Drug-induced osteoporosis (Lower leg)	0.416	0.584	0.000
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.416	0.584	0.000
M81.44 Drug-induced osteoporosis (Hand)	0.416	0.584	0.000
M81.43 Drug-induced osteoporosis (Forearm)	0.416	0.584	0.000
M81.42 Drug-induced osteoporosis (Upper arm)	0.416	0.584	0.000
M81.41 Drug-induced osteoporosis (Shoulder region)	0.416	0.584	0.000
M85.20 Hyperostosis of skull-Mult sites	0.415	0.585	0.000
M85.68 Other cyst of bone (Other)	0.407	0.592	0.000
M80.8 Other osteoporosis with pathological fracture	0.404	0.596	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.399	0.601	0.000
T42.4 Benzodiazepines	0.000	0.607	0.393
M83.12 Senile osteomalacia (Upper arm)	0.380	0.620	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.000	0.623	0.377
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.377	0.623	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.375	0.625	0.000
M81.40 Drug-induced osteoporosis (Multiple sites)	0.374	0.626	0.000
M83.19 Senile osteomalacia (Site unspecified)	0.367	0.633	0.000
M83.18 Senile osteomalacia (Other)	0.367	0.633	0.000
M83.17 Senile osteomalacia (Ankle and foot)	0.367	0.633	0.000
M83.16 Senile osteomalacia (Lower leg)	0.367	0.633	0.000
M83.15 Senile osteomalacia (Pelvic region and thigh)	0.367	0.633	0.000
M83.14 Senile osteomalacia (Hand)	0.367	0.633	0.000
M83.13 Senile osteomalacia (Forearm)	0.367	0.633	0.000
M83.11 Senile osteomalacia (Shoulder region)	0.367	0.633	0.000
M83.10 Senile osteomalacia (Multiple sites)	0.367	0.633	0.000
M81.20 Osteoporosis of disuse (Multiple sites)	0.365	0.635	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.363	0.637	0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.363	0.637	0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.363	0.637	0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.363	0.637	0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.363	0.637	0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.363	0.637	0.000
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.360	0.640	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.360	0.640	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.360	0.640	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.360	0.640	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.360	0.640	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.360	0.640	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.360	0.640	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.360	0.640	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.360	0.640	0.000
M81.49 Drug-induced osteoporosis (Site unspecified)	0.360	0.640	0.000
M83.09 Puerperal osteomalacia (Site unspecified)	0.358	0.641	0.000
M83.08 Puerperal osteomalacia (Other)	0.358	0.641	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations