TreeWAS – Variant ID: rs16945612

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
H72.9 Perforation of tympanic membrane, unspecified	0.109	0.891	0.000
H72 Perforation of tympanic membrane	0.107	0.893	0.000
H65-H75 Diseases of middle ear and mastoid	0.105	0.895	0.000
H71 Cholesteatoma of middle ear	0.100	0.900	0.000
H66 Suppurative and unspecified otitis media	0.091	0.909	0.000
H73 Other disorders of tympanic membrane	0.088	0.912	0.000
H74 Other disorders of middle ear and mastoid	0.085	0.915	0.000
H72.2 Other marginal perforations of tympanic membrane	0.080	0.920	0.000
H72.0 Central perforation of tympanic membrane	0.079	0.921	0.000
H70 Mastoiditis and related conditions	0.077	0.922	0.000
H69 Other disorders of Eustachian tube	0.077	0.923	0.000
H66.9 Otitis media, unspecified	0.077	0.923	0.000
H72.1 Attic perforation of tympanic membrane	0.076	0.923	0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.076	0.924	0.000
H68 Eustachian salpingitis and obstruction	0.076	0.924	0.000
H67 Otitis media in diseases classified elsewhere	0.076	0.924	0.000
H72.8 Other perforations of tympanic membrane	0.074	0.925	0.000
H33.0 Retinal detachment with retinal break	0.000	0.927	0.073
H73.8 Other specified disorders of tympanic membrane	0.071	0.929	0.000
H74.9 Disorder of middle ear and mastoid, unspecified	0.071	0.929	0.000
H66.2 Chronic atticoantral suppurative otitis media	0.071	0.929	0.000
H73.9 Disorder of tympanic membrane, unspecified	0.069	0.931	0.000
H66.3 Other chronic suppurative otitis media	0.069	0.931	0.000
H74.4 Polyp of middle ear	0.066	0.934	0.000
H66.1 Chronic tubotympanic suppurative otitis media	0.066	0.934	0.000
H66.0 Acute suppurative otitis media	0.066	0.934	0.000
H66.4 Suppurative otitis media, unspecified	0.066	0.934	0.000
H73.1 Chronic myringitis	0.063	0.937	0.000
H73.0 Acute myringitis	0.063	0.937	0.000
H74.3 Other acquired abnormalities of ear ossicles	0.063	0.937	0.000
H65 Nonsuppurative otitis media	0.061	0.938	0.000
H74.2 Discontinuity and dislocation of ear ossicles	0.061	0.939	0.000
H74.1 Adhesive middle ear disease	0.061	0.939	0.000
H69.9 Eustachian tube disorder, unspecified	0.060	0.940	0.000
H74.0 Tympanosclerosis	0.059	0.941	0.000
H70.9 Mastoiditis, unspecified	0.058	0.942	0.000
Chapter VIII Diseases of the ear and mastoid process	0.058	0.942	0.000
H74.8 Other specified disorders of middle ear and mastoid	0.057	0.942	0.000
H70.8 Other mastoiditis and related conditions	0.056	0.944	0.000
H70.2 Petrositis	0.056	0.944	0.000
H70.1 Chronic mastoiditis	0.056	0.944	0.000
H70.0 Acute mastoiditis	0.056	0.944	0.000
H69.0 Patulous Eustachian tube	0.055	0.945	0.000
H33 Retinal detachments and breaks	0.000	0.945	0.055
H67.8 Otitis media in other diseases classified elsewhere	0.054	0.945	0.000
H67.1 Otitis media in viral diseases classified elsewhere	0.054	0.945	0.000
H67.0 Otitis media in bacterial diseases classified elsewhere	0.054	0.945	0.000
H68.1 Obstruction of Eustachian tube	0.054	0.945	0.000
H68.0 Eustachian salpingitis	0.054	0.945	0.000
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere	0.054	0.945	0.000
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere	0.054	0.945	0.000
C80.0 Malignant neoplasm, primary site unknown, so stated	0.052	0.948	0.000
C80 Malignant neoplasm without specification of site	0.052	0.948	0.000
H69.8 Other specified disorders of Eustachian tube	0.051	0.949	0.000
C77.2 Intra-abdominal lymph nodes	0.051	0.949	0.000
H90-H95 Other disorders of ear	0.050	0.950	0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.050	0.950	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.050	0.950	0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes	0.049	0.951	0.000
H33.2 Serous retinal detachment	0.000	0.951	0.049
C77.0 Lymph nodes of head, face and neck	0.049	0.951	0.000
H65.2 Chronic serous otitis media	0.048	0.952	0.000
H33.5 Other retinal detachments	0.000	0.952	0.048
H65.4 Other chronic nonsuppurative otitis media	0.048	0.952	0.000
H60-H62 Diseases of external ear	0.047	0.953	0.000
C80.9 Malignant neoplasm, unspecified	0.047	0.953	0.000
C78.7 Secondary malignant neoplasm of liver	0.046	0.954	0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum	0.045	0.955	0.000
H33.4 Traction detachment of retina	0.000	0.955	0.045
H33.1 Retinoschisis and retinal cysts	0.000	0.955	0.045
C78.4 Secondary malignant neoplasm of small intestine	0.044	0.955	0.000
C78.2 Secondary malignant neoplasm of pleura	0.045	0.955	0.000
H65.1 Other acute nonsuppurative otitis media	0.044	0.956	0.000
H65.0 Acute serous otitis media	0.044	0.956	0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.043	0.957	0.000
C77.5 Intrapelvic lymph nodes	0.042	0.958	0.000
H93 Other disorders of ear, not elsewhere classified	0.042	0.958	0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs	0.041	0.959	0.000
H60 Otitis externa	0.040	0.960	0.000
H91 Other hearing loss	0.039	0.961	0.000
H95.1 Other disorders following mastoidectomy	0.038	0.962	0.000
H92 Otalgia and effusion of ear	0.038	0.962	0.000
H94 Other disorders of ear in diseases classified elsewhere	0.036	0.964	0.000
C76 Malignant neoplasm of other and ill-defined sites	0.036	0.964	0.000
H93.1 Tinnitus	0.035	0.965	0.000
H65.9 Nonsuppurative otitis media, unspecified	0.034	0.965	0.000
H62 Disorders of external ear in diseases classified elsewhere	0.034	0.966	0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs	0.034	0.966	0.000
H61 Other disorders of external ear	0.034	0.966	0.000
H93.9 Disorder of ear, unspecified	0.034	0.966	0.000
C78.1 Secondary malignant neoplasm of mediastinum	0.033	0.967	0.000
H60.3 Other infective otitis externa	0.033	0.967	0.000
H91.8 Other specified hearing loss	0.032	0.968	0.000
C77.4 Inguinal and lower limb lymph nodes	0.032	0.968	0.000
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity	0.032	0.968	0.000
H92.1 Otorrhoea	0.032	0.968	0.000
H95.9 Postprocedural disorder of ear and mastoid process, unspecified	0.031	0.969	0.000
H95.8 Other postprocedural disorders of ear and mastoid process	0.031	0.969	0.000
H60.0 Abscess of external ear	0.031	0.969	0.000
H60.1 Cellulitis of external ear	0.031	0.969	0.000
H93.3 Disorders of acoustic nerve	0.031	0.969	0.000
H93.2 Other abnormal auditory perceptions	0.031	0.969	0.000
H93.0 Degenerative and vascular disorders of ear	0.031	0.969	0.000
H61.8 Other specified disorders of external ear	0.031	0.969	0.000
H60.4 Cholesteatoma of external ear	0.030	0.970	0.000
H93.8 Other specified disorders of ear	0.030	0.970	0.000
H65.3 Chronic mucoid otitis media	0.029	0.971	0.000
C77.9 Lymph node, unspecified	0.029	0.971	0.000
H60.2 Malignant otitis externa	0.029	0.971	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.029	0.971	0.000
H60.9 Otitis externa, unspecified	0.029	0.971	0.000
H60.5 Acute otitis externa, non-infective	0.028	0.971	0.000
H91.2 Sudden idiopathic hearing loss	0.028	0.972	0.000
H91.1 Presbycusis	0.028	0.972	0.000
H91.0 Ototoxic hearing loss	0.028	0.972	0.000
H91.3 Deaf mutism, not elsewhere classified	0.028	0.972	0.000
H60.8 Other otitis externa	0.028	0.972	0.000
H91.9 Hearing loss, unspecified	0.028	0.972	0.000
H92.2 Otorrhagia	0.028	0.972	0.000
H61.2 Impacted cerumen	0.027	0.973	0.000
H61.9 Disorder of external ear, unspecified	0.026	0.973	0.000
H94.8 Other specified disorders of ear in diseases classified elsewhere	0.026	0.974	0.000
H94.0 Acoustic neuritis in infectious and parasitic diseases classified elsewhere	0.026	0.974	0.000
H80-H83 Diseases of inner ear	0.026	0.974	0.000
C76.8 Overlapping lesion of other and ill-defined sites	0.026	0.974	0.000
C76.7 Other ill-defined sites	0.026	0.974	0.000
C76.5 Lower limb	0.026	0.974	0.000
C76.4 Upper limb	0.026	0.974	0.000
C76.3 Pelvis	0.026	0.974	0.000
C76.2 Abdomen	0.026	0.974	0.000
C76.1 Thorax	0.026	0.974	0.000
C76.0 Head, face and neck	0.026	0.974	0.000
H62.8 Other disorders of external ear in diseases classified elsewhere	0.025	0.975	0.000
H62.4 Otitis externa in other diseases classified elsewhere	0.025	0.975	0.000
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere	0.025	0.975	0.000
H62.2 Otitis externa in mycoses	0.025	0.975	0.000
H62.1 Otitis externa in viral diseases classified elsewhere	0.025	0.975	0.000
H62.0 Otitis externa in bacterial diseases classified elsewhere	0.025	0.975	0.000
H61.3 Acquired stenosis of external ear canal	0.025	0.975	0.000
H92.0 Otalgia	0.025	0.975	0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum	0.023	0.977	0.000
C77.8 Lymph nodes of multiple regions	0.021	0.979	0.000
H90 Conductive and sensorineural hearing loss	0.021	0.979	0.000
H61.1 Non-infective disorders of pinna	0.020	0.980	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.020	0.980	0.000
H82 Vertiginous syndromes in diseases classified elsewhere	0.019	0.981	0.000
H83 Other diseases of inner ear	0.018	0.982	0.000
C78.0 Secondary malignant neoplasm of lung	0.018	0.982	0.000
C77.3 Axillary and upper limb lymph nodes	0.018	0.982	0.000
H80 Otosclerosis	0.017	0.982	0.000
T82.1 Mechanical complication of cardiac electronic device	0.017	0.983	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.017	0.983	0.000
T82.4 Mechanical complication of vascular dialysis catheter	0.017	0.983	0.000
T82.3 Mechanical complication of other vascular grafts	0.017	0.983	0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.016	0.984	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.016	0.984	0.000
H90.5 Sensorineural hearing loss, unspecified	0.016	0.984	0.000
C77.1 Intrathoracic lymph nodes	0.016	0.984	0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.015	0.985	0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.015	0.985	0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.015	0.985	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.014	0.985	0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.014	0.986	0.000
T82.0 Mechanical complication of heart valve prosthesis	0.014	0.986	0.000
H83.9 Disease of inner ear, unspecified	0.014	0.986	0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.014	0.986	0.000
H83.8 Other specified diseases of inner ear	0.013	0.986	0.000
H83.3 Noise effects on inner ear	0.013	0.987	0.000
H83.2 Labyrinthine dysfunction	0.013	0.987	0.000
H83.1 Labyrinthine fistula	0.013	0.987	0.000
H80.8 Other otosclerosis	0.013	0.987	0.000
H80.2 Cochlear otosclerosis	0.013	0.987	0.000
H80.1 Otosclerosis involving oval window, obliterative	0.013	0.987	0.000
H80.0 Otosclerosis involving oval window, nonobliterative	0.013	0.987	0.000
H90.3 Sensorineural hearing loss, bilateral	0.012	0.988	0.000
H90.0 Conductive hearing loss, bilateral	0.011	0.988	0.000
H80.9 Otosclerosis, unspecified	0.011	0.989	0.000
H90.2 Conductive hearing loss, unspecified	0.011	0.989	0.000
H61.0 Perichondritis of external ear	0.010	0.989	0.000
H83.0 Labyrinthitis	0.010	0.990	0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.010	0.990	0.000
E87.6 Hypokalaemia	0.010	0.990	0.000
H81 Disorders of vestibular function	0.009	0.991	0.000
H33.3 Retinal breaks without detachment	0.000	0.992	0.008
I61.9 Intracerebral haemorrhage, unspecified	0.000	0.992	0.008
R21 Rash and other nonspecific skin eruption	0.008	0.992	0.000
H81.8 Other disorders of vestibular function	0.007	0.992	0.000
N45.9 Orchitis, epididymitis and epididymo-orchitis without abscess	0.000	0.993	0.007
H81.4 Vertigo of central origin	0.007	0.993	0.000
H81.3 Other peripheral vertigo	0.007	0.993	0.000
H81.9 Disorder of vestibular function, unspecified	0.006	0.993	0.000
H81.2 Vestibular neuronitis	0.006	0.994	0.000
H30-H36 Disorders of choroid and retina	0.000	0.994	0.006
H53.8 Other visual disturbances	0.000	0.994	0.006
I61 Intracerebral haemorrhage	0.000	0.994	0.006
I64 Stroke, not specified as haemorrhage or infarction	0.000	0.995	0.005
H81.1 Benign paroxysmal vertigo	0.004	0.995	0.000
I61.5 Intracerebral haemorrhage, intraventricular	0.000	0.995	0.005
H81.0 Meniere's disease	0.005	0.995	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.000	0.995	0.004
I61.8 Other intracerebral haemorrhage	0.000	0.996	0.004
E55.9 Vitamin D deficiency, unspecified	0.004	0.996	0.000
H34 Retinal vascular occlusions	0.000	0.996	0.004
H32 Chorioretinal disorders in diseases classified elsewhere	0.000	0.996	0.004
H30 Chorioretinal inflammation	0.000	0.996	0.004
I61.6 Intracerebral haemorrhage, multiple localised	0.000	0.996	0.004
I61.2 Intracerebral haemorrhage in hemisphere, unspecified	0.000	0.996	0.004
N99.3 Prolapse of vaginal vault after hysterectomy	0.000	0.996	0.004
I61.1 Intracerebral haemorrhage in hemisphere, cortical	0.000	0.996	0.004
L03.0 Cellulitis of finger and toe	0.004	0.996	0.000
C79 Secondary malignant neoplasm of other sites	0.004	0.996	0.000
S01.1 Open wound of eyelid and periocular area	0.004	0.996	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.000	0.996	0.004
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.004	0.996	0.000
S86.8 Injury of other muscles and tendons at lower leg level	0.004	0.996	0.000
I61.4 Intracerebral haemorrhage in cerebellum	0.000	0.996	0.004
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified	0.000	0.996	0.004
H31 Other disorders of choroid	0.000	0.996	0.003
I60-I69 Cerebrovascular diseases	0.000	0.996	0.004
H34.8 Other retinal vascular occlusions	0.000	0.996	0.003
N99.5 Malfunction of external stoma of urinary tract	0.000	0.997	0.003
H34.9 Retinal vascular occlusion, unspecified	0.000	0.997	0.003
H34.0 Transient retinal artery occlusion	0.000	0.997	0.003
H30.9 Chorioretinal inflammation, unspecified	0.000	0.997	0.003
H30.8 Other chorioretinal inflammations	0.000	0.997	0.003
H30.2 Posterior cyclitis	0.000	0.997	0.003
H30.1 Disseminated chorioretinal inflammation	0.000	0.997	0.003
H30.0 Focal chorioretinal inflammation	0.000	0.997	0.003
H32.8 Other chorioretinal disorders in diseases classified elsewhere	0.000	0.997	0.003
H32.0 Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere	0.000	0.997	0.003
H34.1 Central retinal artery occlusion	0.000	0.997	0.003
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.003	0.997	0.000
H53 Visual disturbances	0.000	0.997	0.003
S86 Injury of muscle and tendon at lower leg level	0.003	0.997	0.000
C79.6 Secondary malignant neoplasm of ovary	0.003	0.997	0.000
H34.2 Other retinal artery occlusions	0.000	0.997	0.003
S01.9 Open wound of head, part unspecified	0.003	0.997	0.000
S62.60 Fracture of other finger (closed)	0.003	0.997	0.000
H53.2 Diplopia	0.000	0.997	0.003
N99.0 Postprocedural renal failure	0.000	0.997	0.003
S01 Open wound of head	0.003	0.997	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.000	0.997	0.003
N99.8 Other postprocedural disorders of genito-urinary system	0.000	0.997	0.003
S01.0 Open wound of scalp	0.003	0.997	0.000
I69 Sequelae of cerebrovascular disease	0.000	0.997	0.003
H53.4 Visual field defects	0.000	0.997	0.003
Z86.1 Personal history of infectious and parasitic diseases	0.003	0.997	0.000
S01.5 Open wound of lip and oral cavity	0.003	0.997	0.000
E55 Vitamin D deficiency	0.003	0.997	0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs	0.003	0.997	0.000
N45 Orchitis and epididymitis	0.000	0.997	0.003
S82.30 Fracture of lower end of tibia (closed)	0.003	0.997	0.000
Z34.8 Supervision of other normal pregnancy	0.000	0.997	0.003
N99.4 Postprocedural pelvic peritoneal adhesions	0.000	0.997	0.003
E61.1 Iron deficiency	0.003	0.997	0.000
N99.9 Postprocedural disorder of genito-urinary system, unspecified	0.000	0.997	0.003
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.003	0.997	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.000	0.997	0.003
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.000	0.997	0.003
H31.9 Disorder of choroid, unspecified	0.000	0.997	0.003
H31.4 Choroidal detachment	0.000	0.997	0.003
H31.3 Choroidal haemorrhage and rupture	0.000	0.997	0.003
H31.2 Hereditary choroidal dystrophy	0.000	0.997	0.003
S01.4 Open wound of cheek and temporomandibular area	0.003	0.997	0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.000	0.997	0.003
N99.1 Postprocedural urethral stricture	0.000	0.997	0.003
I63 Cerebral infarction	0.000	0.997	0.003
H36 Retinal disorders in diseases classified elsewhere	0.000	0.997	0.003
H31.0 Chorioretinal scars	0.000	0.997	0.003
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system	0.003	0.997	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.000	0.997	0.003
H53.6 Night blindness	0.000	0.997	0.003
H53.5 Colour vision deficiencies	0.000	0.997	0.003
H53.3 Other disorders of binocular vision	0.000	0.997	0.003
S86.0 Injury of Achilles tendon	0.003	0.997	0.000
S86.7 Injury of multiple muscles and tendons at lower leg level	0.003	0.997	0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.003	0.997	0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.003	0.997	0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis	0.003	0.997	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.000	0.997	0.003
I67.1 Cerebral aneurysm, nonruptured	0.000	0.997	0.003
M48.02 Spinal stenosis (Cervical region)	0.003	0.997	0.000
H31.8 Other specified disorders of choroid	0.000	0.997	0.002
C79.2 Secondary malignant neoplasm of skin	0.002	0.997	0.000
E55.0 Rickets, active	0.002	0.997	0.000
N99.2 Postprocedural adhesions of vagina	0.000	0.997	0.002
S01.3 Open wound of ear	0.002	0.997	0.000
H31.1 Choroidal degeneration	0.000	0.997	0.002
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.000	0.997	0.002
E61 Deficiency of other nutrient elements	0.002	0.997	0.000
N45.0 Orchitis, epididymitis and epididymo-orchitis with abscess	0.000	0.998	0.002
S01.2 Open wound of nose	0.002	0.998	0.000
I60 Subarachnoid haemorrhage	0.000	0.998	0.002
Y85.0 Sequelae of motor-vehicle accident	0.002	0.998	0.000
I63.8 Other cerebral infarction	0.000	0.998	0.002
S89.8 Other specified injuries of lower leg	0.002	0.998	0.000
C79.9 Secondary malignant neoplasm, unspecified site	0.002	0.998	0.000
C91.1 Chronic lymphocytic leukaemia	0.002	0.998	0.000
H53.0 Amblyopia ex anopsia	0.000	0.998	0.002
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.000	0.998	0.002
I67 Other cerebrovascular diseases	0.000	0.998	0.002
Z37.0 Single live birth	0.000	0.998	0.002
Y88 Sequelae of surgical and medical care as external cause	0.002	0.998	0.000
S01.7 Multiple open wounds of head	0.002	0.998	0.000
I66.9 Occlusion and stenosis of unspecified cerebral artery	0.000	0.998	0.002
I66.8 Occlusion and stenosis of other cerebral artery	0.000	0.998	0.002
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries	0.000	0.998	0.002
I66.3 Occlusion and stenosis of cerebellar arteries	0.000	0.998	0.002
I66.2 Occlusion and stenosis of posterior cerebral artery	0.000	0.998	0.002
I66.1 Occlusion and stenosis of anterior cerebral artery	0.000	0.998	0.002
I66.0 Occlusion and stenosis of middle cerebral artery	0.000	0.998	0.002
I68.8 Other cerebrovascular disorders in diseases classified elsewhere	0.000	0.998	0.002
I68.2 Cerebral arteritis in other diseases classified elsewhere	0.000	0.998	0.002
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere	0.000	0.998	0.002
I68.0 Cerebral amyloid angiopathy	0.000	0.998	0.002
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.000	0.998	0.002
I60.9 Subarachnoid haemorrhage, unspecified	0.000	0.998	0.002
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.000	0.998	0.002
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.000	0.998	0.002
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.000	0.998	0.002
C79.5 Secondary malignant neoplasm of bone and bone marrow	0.002	0.998	0.000
H36.8 Other retinal disorders in diseases classified elsewhere	0.000	0.998	0.002
H53.1 Subjective visual disturbances	0.000	0.998	0.002
S86.00 Unspecified injury of Achilles tendon	0.002	0.998	0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery	0.000	0.998	0.002
Z51.5 Palliative care	0.002	0.998	0.000
S82.3 Fracture of lower end of tibia	0.002	0.998	0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.000	0.998	0.002
S89 Other and unspecified injuries of lower leg	0.002	0.998	0.000
C79.7 Secondary malignant neoplasm of adrenal gland	0.002	0.998	0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.000	0.998	0.002
S89.9 Unspecified injury of lower leg	0.002	0.998	0.000
C44.6 Skin of upper limb, including shoulder	0.000	0.998	0.002
E61.2 Magnesium deficiency	0.002	0.998	0.000
H26.4 After-cataract	0.000	0.998	0.002
N12 Tubulo-interstitial nephritis, not specified as acute or chronic	0.002	0.998	0.000
E50-E64 Other nutritional deficiencies	0.002	0.998	0.000
E61.9 Deficiency of nutrient element, unspecified	0.002	0.998	0.000
E61.8 Deficiency of other specified nutrient elements	0.002	0.998	0.000
E61.7 Deficiency of multiple nutrient elements	0.002	0.998	0.000
E61.6 Vanadium deficiency	0.002	0.998	0.000
E61.5 Molybdenum deficiency	0.002	0.998	0.000
E61.4 Chromium deficiency	0.002	0.998	0.000
E61.3 Manganese deficiency	0.002	0.998	0.000
E61.0 Copper deficiency	0.002	0.998	0.000
H53.9 Visual disturbance, unspecified	0.000	0.998	0.002
I60.5 Subarachnoid haemorrhage from vertebral artery	0.000	0.998	0.002
I60.4 Subarachnoid haemorrhage from basilar artery	0.000	0.998	0.002
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.000	0.998	0.002
C79.8 Secondary malignant neoplasm of other specified sites	0.002	0.998	0.000
D41.4 Bladder	0.002	0.998	0.000
I67.7 Cerebral arteritis, not elsewhere classified	0.000	0.998	0.002
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.000	0.998	0.002
I67.5 Moyamoya disease	0.000	0.998	0.002
I67.4 Hypertensive encephalopathy	0.000	0.998	0.002
I67.3 Progressive vascular leukoencephalopathy	0.000	0.998	0.002
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.002	0.998	0.000
Y88.2 Sequelae of adverse incidents associated with medical devices in diagnostic and therapeutic use	0.002	0.998	0.000
Y88.1 Sequelae of misadventures to patients during surgical and medical procedures	0.002	0.998	0.000
Y88.0 Sequelae of adverse effects caused by drugs, medicaments and biological substances in therapeutic use	0.002	0.998	0.000
H00.1 Chalazion	0.000	0.998	0.002
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.000	0.998	0.002
S82.31 Fracture of lower end of tibia (open)	0.002	0.998	0.000
Z90.4 Acquired absence of other parts of digestive tract	0.002	0.998	0.000
Z93.2 Ileostomy status	0.002	0.998	0.000
I62 Other nontraumatic intracranial haemorrhage	0.000	0.998	0.002
S06.00 Concussion (without open intracranial wound)	0.002	0.998	0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk	0.000	0.998	0.002
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.000	0.998	0.002
I65.8 Occlusion and stenosis of other precerebral artery	0.000	0.998	0.002
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.000	0.998	0.002
I65.1 Occlusion and stenosis of basilar artery	0.000	0.998	0.002
I69.3 Sequelae of cerebral infarction	0.000	0.998	0.002
S89.7 Multiple injuries of lower leg	0.002	0.998	0.000
S89.1 Other specified injuries of lower leg	0.002	0.998	0.000
S89.0 Multiple injuries of lower leg	0.002	0.998	0.000
I46.0 Cardiac arrest with successful resuscitation	0.000	0.998	0.002
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.000	0.998	0.002
Z86.5 Personal history of other mental and behavioural disorders	0.000	0.998	0.002
Y85 Sequelae of transport accidents	0.002	0.998	0.000
A41.1 Septicaemia due to other specified staphylococcus	0.002	0.998	0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms	0.002	0.998	0.000
I60.8 Other subarachnoid haemorrhage	0.000	0.998	0.002
H35.0 Background retinopathy and retinal vascular changes	0.000	0.998	0.002
C91.0 Acute lymphoblastic leukaemia	0.002	0.998	0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.000	0.998	0.002
C91 Lymphoid leukaemia	0.002	0.998	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.002	0.998	0.000
E63 Other nutritional deficiencies	0.002	0.998	0.000
E56 Other vitamin deficiencies	0.002	0.998	0.000
E51 Thiamine deficiency	0.002	0.998	0.000
E50 Vitamin A deficiency	0.002	0.998	0.000
E60 Dietary zinc deficiency	0.002	0.998	0.000
E59 Dietary selenium deficiency	0.002	0.998	0.000
E58 Dietary calcium deficiency	0.002	0.998	0.000
E54 Ascorbic acid deficiency	0.002	0.998	0.000
E52 Niacin deficiency [pellagra]	0.002	0.998	0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.000	0.998	0.002
I65.0 Occlusion and stenosis of vertebral artery	0.000	0.998	0.002
I67.0 Dissection of cerebral arteries, nonruptured	0.000	0.998	0.002
S80-S89 Injuries to the knee and lower leg	0.002	0.998	0.000
J43.9 Emphysema, unspecified	0.002	0.998	0.000
I35.1 Aortic (valve) insufficiency	0.000	0.998	0.002
H35 Other retinal disorders	0.000	0.998	0.002
Y42.7 Androgens and anabolic congeners	0.000	0.998	0.002
Y42.5 Other oestrogens and progestogens	0.000	0.998	0.002
R39.1 Other difficulties with micturition	0.000	0.998	0.002
S80.8 Other superficial injuries of lower leg	0.002	0.998	0.000
C91.5 Adult T-cell leukaemia	0.002	0.998	0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms	0.002	0.998	0.000
H35.2 Other proliferative retinopathy	0.000	0.998	0.002
I67.8 Other specified cerebrovascular diseases	0.000	0.998	0.002
Z86.3 Personal history of endocrine, nutritional and metabolic diseases	0.002	0.998	0.000
H20.9 Iridocyclitis, unspecified	0.000	0.998	0.002
M13.97 Arthritis, unspecified (Ankle and foot)	0.000	0.998	0.002
I62.1 Nontraumatic extradural haemorrhage	0.000	0.998	0.001
K82.8 Other specified diseases of gallbladder	0.002	0.998	0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.000	0.998	0.001
S91.3 Open wound of other parts of foot	0.002	0.998	0.000
M11.26 Other chondrocalcinosis (Lower leg)	0.000	0.998	0.002
M47.96 Spondylosis, unspecified (Lumbar region)	0.000	0.998	0.002
F31.8 Other bipolar affective disorders	0.002	0.998	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.000	0.998	0.002
N99-N99 Other disorders of the genitourinary system	0.000	0.998	0.002
F33.9 Recurrent depressive disorder, unspecified	0.002	0.998	0.000
K12.2 Cellulitis and abscess of mouth	0.002	0.998	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.998	0.002
Z39.0 Care and examination immediately after delivery	0.000	0.998	0.002
E50.9 Vitamin A deficiency, unspecified	0.001	0.998	0.000
E50.8 Other manifestations of vitamin A deficiency	0.001	0.998	0.000
E50.7 Other ocular manifestations of vitamin A deficiency	0.001	0.998	0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.001	0.998	0.000
E50.5 Vitamin A deficiency with night blindness	0.001	0.998	0.000
E50.4 Vitamin A deficiency with keratomalacia	0.001	0.998	0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.001	0.998	0.000
E50.2 Vitamin A deficiency with corneal xerosis	0.001	0.998	0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.001	0.998	0.000
E50.0 Vitamin A deficiency with conjunctival xerosis	0.001	0.998	0.000
E51.9 Thiamine deficiency, unspecified	0.001	0.998	0.000
E51.8 Other manifestations of thiamine deficiency	0.001	0.998	0.000
E51.2 Wernicke's encephalopathy	0.001	0.998	0.000
E51.1 Beriberi	0.001	0.998	0.000
E56.9 Vitamin deficiency, unspecified	0.001	0.998	0.000
E56.8 Deficiency of other vitamins	0.001	0.998	0.000
E56.1 Deficiency of vitamin K	0.001	0.998	0.000
E56.0 Deficiency of vitamin E	0.001	0.998	0.000
E63.9 Nutritional deficiency, unspecified	0.001	0.998	0.000
E63.8 Other specified nutritional deficiencies	0.001	0.998	0.000
E63.1 Imbalance of constituents of food intake	0.001	0.998	0.000
E63.0 Essential fatty acid [EFA] deficiency	0.001	0.998	0.000
E64.9 Sequelae of unspecified nutritional deficiency	0.001	0.998	0.000
E64.8 Sequelae of other nutritional deficiencies	0.001	0.998	0.000
E64.3 Sequelae of rickets	0.001	0.998	0.000
E64.2 Sequelae of vitamin C deficiency	0.001	0.998	0.000
E64.1 Sequelae of vitamin A deficiency	0.001	0.998	0.000
E64.0 Sequelae of protein-energy malnutrition	0.001	0.998	0.000
F31 Bipolar affective disorder	0.002	0.998	0.000
C91.8 Mature B-cell leukaemia Burkitt-type	0.001	0.998	0.000
C91.7 Other lymphoid leukaemia	0.001	0.998	0.000
C91.6 Prolymphocytic leukaemia of T-cell type	0.001	0.998	0.000
C91.3 Prolymphocytic leukaemia	0.001	0.998	0.000
C91.2 Subacute lymphocytic leukaemia	0.001	0.998	0.000
K82.1 Hydrops of gallbladder	0.002	0.998	0.000
R41.0 Disorientation, unspecified	0.000	0.998	0.002
S88 Traumatic amputation of lower leg	0.001	0.998	0.000
S87 Crushing injury of lower leg	0.001	0.998	0.000
S85 Injury of blood vessels at lower leg level	0.001	0.998	0.000
S84 Injury of nerves at lower leg level	0.001	0.998	0.000
C91.4 Hairy-cell leukaemia	0.001	0.998	0.000
Z43.1 Attention to gastrostomy	0.000	0.998	0.002
H35.1 Retinopathy of prematurity	0.000	0.998	0.001
R50.9 Fever, unspecified	0.002	0.998	0.000
C91.9 Lymphoid leukaemia, unspecified	0.001	0.998	0.000
F31.7 Bipolar affective disorder, currently in remission	0.001	0.998	0.000
I67.2 Cerebral atherosclerosis	0.000	0.998	0.001
E53 Deficiency of other B group vitamins	0.001	0.998	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.998	0.001
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.001	0.998	0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms	0.001	0.999	0.000
H35.6 Retinal haemorrhage	0.000	0.999	0.001
S82 Fracture of lower leg, including ankle	0.001	0.999	0.000
H20.0 Acute and subacute iridocyclitis	0.000	0.999	0.001
H35.9 Retinal disorder, unspecified	0.000	0.999	0.001
S82.51 Fracture of medial malleolus (open)	0.001	0.999	0.000
N30.9 Cystitis, unspecified	0.001	0.999	0.000
O63.1 Prolonged second stage (of labour)	0.000	0.999	0.001
S82.5 Fracture of medial malleolus	0.001	0.999	0.000
Y85.9 Sequelae of other and unspecified transport accidents	0.001	0.999	0.000
R12 Heartburn	0.000	0.999	0.001
S81 Open wound of lower leg	0.001	0.999	0.000
E87.7 Fluid overload	0.000	0.999	0.001
S83.2 Tear of meniscus, current	0.000	0.999	0.001
F31.3 Bipolar affective disorder, current episode mild or moderate depression	0.001	0.999	0.000
Z36.9 Antenatal screening, unspecified	0.001	0.999	0.000
M00.91 Pyogenic arthritis, unspecified (Shoulder region)	0.001	0.999	0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified	0.000	0.999	0.001
C79.3 Secondary malignant neoplasm of brain and cerebral meninges	0.001	0.999	0.000
F31.6 Bipolar affective disorder, current episode mixed	0.001	0.999	0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms	0.001	0.999	0.000
F31.0 Bipolar affective disorder, current episode hypomanic	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations