TreeWAS – Variant ID: rs17065417

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K80.5 Calculus of bile duct without cholangitis or cholecystitis	0.000	0.679	0.321
K80 Cholelithiasis	0.000	0.688	0.312
K80.2 Calculus of gallbladder without cholecystitis	0.000	0.688	0.312
K80.0 Calculus of gallbladder with acute cholecystitis	0.000	0.725	0.275
K80.4 Calculus of bile duct with cholecystitis	0.000	0.747	0.253
K80.3 Calculus of bile duct with cholangitis	0.000	0.776	0.224
K80.1 Calculus of gallbladder with other cholecystitis	0.000	0.797	0.203
K80.36 Calculus of bile duct with acute and chronic cholangitis without obstruction	0.000	0.839	0.160
K80.8 Other cholelithiasis	0.000	0.859	0.140
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.000	0.978	0.022
K85 Acute pancreatitis	0.000	0.983	0.017
K87 Disorders of gallbladder, biliary tract and pancreas in diseases classified elsewhere	0.000	0.984	0.016
K81 Cholecystitis	0.000	0.984	0.016
K85.9 Acute pancreatitis, unspecified	0.000	0.985	0.015
K81.1 Chronic cholecystitis	0.000	0.986	0.014
K86 Other diseases of pancreas	0.000	0.987	0.013
K86.1 Other chronic pancreatitis	0.000	0.987	0.013
K85.8 Other acute pancreatitis	0.000	0.988	0.012
K85.3 Drug-induced acute pancreatitis	0.000	0.988	0.012
K85.0 Idiopathic acute pancreatitis	0.000	0.988	0.012
K81.0 Acute cholecystitis	0.000	0.988	0.012
K85.2 Alcohol-induced acute pancreatitis	0.000	0.988	0.012
K87.1 Disorders of pancreas in diseases classified elsewhere	0.000	0.988	0.012
K87.0 Disorders of gallbladder and biliary tract in diseases classified elsewhere	0.000	0.988	0.012
K81.8 Other cholecystitis	0.000	0.988	0.012
K86.3 Pseudocyst of pancreas	0.000	0.990	0.010
Y45.0 Opioids and related analgesics	0.010	0.990	0.000
K86.0 Alcohol-induced chronic pancreatitis	0.000	0.990	0.010
K85.1 Biliary acute pancreatitis	0.000	0.991	0.009
Y52 Agents primarily affecting the cardiovascular system	0.009	0.991	0.000
K86.8 Other specified diseases of pancreas	0.000	0.992	0.008
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.008	0.992	0.000
Y52.4 Angiotensin-converting-enzyme inhibitors	0.008	0.992	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.008	0.992	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.008	0.992	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.007	0.993	0.000
K83 Other diseases of biliary tract	0.000	0.993	0.007
Y52.1 Calcium-channel blockers	0.007	0.993	0.000
D62 Acute posthaemorrhagic anaemia	0.007	0.993	0.000
K81.9 Cholecystitis, unspecified	0.000	0.993	0.007
Y40 Systemic antibiotics	0.007	0.993	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.006	0.993	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.006	0.993	0.000
Y52.7 Peripheral vasodilators	0.006	0.993	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.006	0.993	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.006	0.993	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.007	0.993	0.000
Y40.0 Penicillins	0.006	0.994	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.006	0.994	0.000
Y45.1 Salicylates	0.006	0.994	0.000
K86.2 Cyst of pancreas	0.000	0.994	0.006
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.006	0.994	0.000
Y45.8 Other analgesics and antipyretics	0.006	0.994	0.000
Y44 Agents primarily affecting blood constituents	0.006	0.994	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.006	0.994	0.000
K86.9 Disease of pancreas, unspecified	0.000	0.994	0.006
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.006	0.994	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.006	0.994	0.000
Y45.4 Antirheumatics	0.006	0.994	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.006	0.994	0.000
D51 Vitamin B12 deficiency anaemia	0.006	0.994	0.000
D50-D53 Nutritional anaemias	0.006	0.994	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.006	0.994	0.000
Y42.5 Other oestrogens and progestogens	0.006	0.994	0.000
D23.5 Skin of trunk	0.006	0.994	0.000
Y40.7 Antifungal antibiotics, systemically used	0.006	0.994	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.006	0.994	0.000
Y42.2 Antithyroid drugs	0.006	0.994	0.000
D52.9 Folate deficiency anaemia, unspecified	0.006	0.994	0.000
D52 Folate deficiency anaemia	0.006	0.994	0.000
Y48 Anaesthetics and therapeutic gases	0.005	0.994	0.000
Y59 Other and unspecified vaccines and biological substances	0.005	0.994	0.000
Y58 Bacterial vaccines	0.005	0.994	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.005	0.994	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.005	0.994	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.005	0.994	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.005	0.994	0.000
K83.5 Biliary cyst	0.000	0.994	0.005
K83.4 Spasm of sphincter of Oddi	0.000	0.994	0.005
K83.3 Fistula of bile duct	0.000	0.994	0.005
K83.2 Perforation of bile duct	0.000	0.994	0.005
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.005	0.995	0.000
Y45.5 4-Aminophenol derivatives	0.005	0.995	0.000
Y40.9 Systemic antibiotic, unspecified	0.005	0.995	0.000
Y40.3 Macrolides	0.005	0.995	0.000
Y45.2 Propionic acid derivatives	0.005	0.995	0.000
Y40.6 Rifamycins	0.005	0.995	0.000
Y40.5 Aminoglycosides	0.005	0.995	0.000
Y40.4 Tetracyclines	0.005	0.995	0.000
Y40.2 Chloramphenicol group	0.005	0.995	0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.005	0.995	0.000
D60-D64 Aplastic and other anaemias	0.005	0.995	0.000
Y44.2 Anticoagulants	0.005	0.995	0.000
K83.8 Other specified diseases of biliary tract	0.000	0.995	0.005
Y42.9 Other and unspecified hormone antagonists	0.005	0.995	0.000
Y42.4 Oral contraceptives	0.005	0.995	0.000
Y42.1 Thyroid hormones and substitutes	0.005	0.995	0.000
Y46.2 Hydantoin derivatives	0.005	0.995	0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.005	0.995	0.000
Y48.4 Anaesthetic, unspecified	0.005	0.995	0.000
D61 Other aplastic anaemias	0.005	0.995	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.005	0.995	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.005	0.995	0.000
Y41.5 Antiviral drugs	0.005	0.995	0.000
Y54.8 Agents affecting uric acid metabolism	0.005	0.995	0.000
D53 Other nutritional anaemias	0.005	0.995	0.000
Y49.5 Other antipsychotics and neuroleptics	0.005	0.995	0.000
D50 Iron deficiency anaemia	0.005	0.995	0.000
D61.0 Constitutional aplastic anaemia	0.005	0.995	0.000
Y41.0 Sulphonamides	0.005	0.995	0.000
D50.8 Other iron deficiency anaemias	0.005	0.995	0.000
Y42.7 Androgens and anabolic congeners	0.005	0.995	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.004	0.995	0.000
Y44.7 Plasma substitutes	0.004	0.995	0.000
Y44.6 Natural blood and blood products	0.004	0.995	0.000
Y44.5 Thrombolytic drugs	0.004	0.995	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.004	0.995	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.004	0.995	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.004	0.995	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.004	0.995	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.004	0.995	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.004	0.995	0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.004	0.995	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.004	0.995	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.004	0.995	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.004	0.995	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.004	0.995	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.004	0.995	0.000
Y51.0 Anticholinesterase agents	0.004	0.995	0.000
D80-D89 Certain disorders involving the immune mechanism	0.005	0.995	0.000
Y46.6 Other and unspecified antiepileptics	0.004	0.995	0.000
K83.1 Obstruction of bile duct	0.000	0.995	0.004
M48.02 Spinal stenosis (Cervical region)	0.000	0.996	0.004
D51.8 Other vitamin B12 deficiency anaemias	0.004	0.996	0.000
D51.3 Other dietary vitamin B12 deficiency anaemia	0.004	0.996	0.000
D51.2 Transcobalamin II deficiency	0.004	0.996	0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.004	0.996	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.004	0.996	0.000
Y41.4 Anthelminthics	0.004	0.996	0.000
Y41.3 Other antiprotozoal drugs	0.004	0.996	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.004	0.996	0.000
Y41.1 Antimycobacterial drugs	0.004	0.996	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.004	0.996	0.000
Y46.8 Antispasticity drugs	0.004	0.996	0.000
Y46.7 Anti-Parkinsonism drugs	0.004	0.996	0.000
Y46.5 Valproic acid	0.004	0.996	0.000
Y46.3 Deoxybarbiturates	0.004	0.996	0.000
Y46.1 Oxazolidinediones	0.004	0.996	0.000
Y46.0 Succinimides	0.004	0.996	0.000
K83.9 Disease of biliary tract, unspecified	0.000	0.996	0.004
Y53.1 Other antacids and anti-gastric-secretion drugs	0.004	0.996	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.004	0.996	0.000
D86 Sarcoidosis	0.004	0.996	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.004	0.996	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.004	0.996	0.000
Y53.7 Emetics	0.004	0.996	0.000
Y53.6 Antidiarrhoeal drugs	0.004	0.996	0.000
Y53.5 Digestants	0.004	0.996	0.000
Y53.4 Other laxatives	0.004	0.996	0.000
Y53.3 Saline and osmotic laxatives	0.004	0.996	0.000
Y53.2 Stimulant laxatives	0.004	0.996	0.000
Y53.0 Histamine H2-receptor antagonists	0.004	0.996	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.004	0.996	0.000
D52.8 Other folate deficiency anaemias	0.004	0.996	0.000
D52.1 Drug-induced folate deficiency anaemia	0.004	0.996	0.000
D52.0 Dietary folate deficiency anaemia	0.004	0.996	0.000
Y40.8 Other systemic antibiotics	0.004	0.996	0.000
Y48.5 Therapeutic gases	0.004	0.996	0.000
Y48.1 Parenteral anaesthetics	0.004	0.996	0.000
Y48.0 Inhaled anaesthetics	0.004	0.996	0.000
Y48.2 Other and unspecified general anaesthetics	0.004	0.996	0.000
Y50.9 Central nervous system stimulant, unspecified	0.004	0.996	0.000
Y50.8 Other central nervous system stimulants	0.004	0.996	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.004	0.996	0.000
Y50.1 Opioid receptor antagonists	0.004	0.996	0.000
Y50.0 Analeptics	0.004	0.996	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.004	0.996	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.004	0.996	0.000
Y55.5 Anticommon cold drugs	0.004	0.996	0.000
Y55.4 Expectorants	0.004	0.996	0.000
Y55.3 Antitussives	0.004	0.996	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.004	0.996	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.004	0.996	0.000
Y55.0 Oxytocic drugs	0.004	0.996	0.000
Y58.9 Other and unspecified bacterial vaccines	0.004	0.996	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.004	0.996	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.004	0.996	0.000
Y58.5 Diphtheria vaccine	0.004	0.996	0.000
Y58.4 Tetanus vaccine	0.004	0.996	0.000
Y58.3 Plague vaccine	0.004	0.996	0.000
Y58.2 Cholera vaccine	0.004	0.996	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.004	0.996	0.000
Y58.0 BCG vaccine	0.004	0.996	0.000
Y59.9 Vaccine or biological substance, unspecified	0.004	0.996	0.000
Y59.8 Other specified vaccines and biological substances	0.004	0.996	0.000
Y59.3 Immunoglobulin	0.004	0.996	0.000
Y59.2 Protozoal vaccines	0.004	0.996	0.000
Y59.1 Rickettsial vaccines	0.004	0.996	0.000
Y59.0 Viral vaccines	0.004	0.996	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.004	0.996	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.004	0.996	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.004	0.996	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.004	0.996	0.000
Y47.4 Bromine compounds	0.004	0.996	0.000
Y47.3 Paraldehyde	0.004	0.996	0.000
Y47.2 Chloral derivatives	0.004	0.996	0.000
Y47.0 Barbiturates, not elsewhere classified	0.004	0.996	0.000
Y49.9 Psychotropic drug, unspecified	0.004	0.996	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.004	0.996	0.000
Y49.7 Psychostimulants with abuse potential	0.004	0.996	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.004	0.996	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.004	0.996	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.004	0.996	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.004	0.996	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.004	0.996	0.000
D61.1 Drug-induced aplastic anaemia	0.004	0.996	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.004	0.996	0.000
Y47.1 Benzodiazepines	0.004	0.996	0.000
N75.0 Cyst of Bartholin's gland	0.000	0.996	0.004
D80 Immunodeficiency with predominantly antibody defects	0.004	0.996	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.004	0.996	0.000
S22.30 Fracture of rib (closed)	0.004	0.996	0.000
D86.0 Sarcoidosis of lung	0.004	0.996	0.000
Y54.9 Mineral salts, not elsewhere classified	0.004	0.996	0.000
Y54.7 Agents affecting calcification	0.004	0.996	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.004	0.996	0.000
Y54.4 Loop [high-ceiling] diuretics	0.004	0.996	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.004	0.996	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.004	0.996	0.000
Y54.0 Mineralocorticoids	0.004	0.996	0.000
Y57 Other and unspecified drugs and medicaments	0.004	0.996	0.000
D84 Other immunodeficiencies	0.004	0.996	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.004	0.996	0.000
D53.9 Nutritional anaemia, unspecified	0.004	0.996	0.000
Y54.5 Other diuretics	0.004	0.996	0.000
D61.8 Other specified aplastic anaemias	0.004	0.996	0.000
D61.3 Idiopathic aplastic anaemia	0.004	0.996	0.000
D61.2 Aplastic anaemia due to other external agents	0.004	0.996	0.000
Y56.9 Topical agent, unspecified	0.004	0.996	0.000
Y56.8 Other topical agents	0.004	0.996	0.000
Y56.7 Dental drugs, topically applied	0.004	0.996	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.004	0.996	0.000
Y56.5 Ophthalmological drugs and preparations	0.004	0.996	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.004	0.996	0.000
Y56.3 Emollients, demulcents and protectants	0.004	0.996	0.000
Y56.2 Local astringents and local detergents	0.004	0.996	0.000
Y56.1 Antipruritics	0.004	0.996	0.000
Y46.4 Iminostilbenes	0.003	0.996	0.000
D61.9 Aplastic anaemia, unspecified	0.004	0.996	0.000
Y49.2 Other and unspecified antidepressants	0.003	0.996	0.000
D53.8 Other specified nutritional anaemias	0.003	0.996	0.000
D53.2 Scorbutic anaemia	0.003	0.996	0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.003	0.996	0.000
D53.0 Protein deficiency anaemia	0.003	0.996	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.003	0.996	0.000
D50.1 Sideropenic dysphagia	0.003	0.996	0.000
D86.9 Sarcoidosis, unspecified	0.004	0.996	0.000
D83 Common variable immunodeficiency	0.003	0.996	0.000
D82 Immunodeficiency associated with other major defects	0.003	0.996	0.000
D81 Combined immunodeficiencies	0.003	0.996	0.000
D84.1 Defects in the complement system	0.003	0.997	0.000
K82 Other diseases of gallbladder	0.001	0.997	0.003
Y48.3 Local anaesthetics	0.003	0.997	0.000
D55-D59 Haemolytic anaemias	0.003	0.997	0.000
D86.3 Sarcoidosis of skin	0.003	0.997	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.003	0.997	0.000
D86.1 Sarcoidosis of lymph nodes	0.003	0.997	0.000
J02.9 Acute pharyngitis, unspecified	0.000	0.997	0.003
D84.9 Immunodeficiency, unspecified	0.003	0.997	0.000
D86.8 Sarcoidosis of other and combined sites	0.003	0.997	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.003	0.997	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.003	0.997	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.003	0.997	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.003	0.997	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.003	0.997	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.003	0.997	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.003	0.997	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.003	0.997	0.000
Y57.6 Other diagnostic agents	0.003	0.997	0.000
M65.96 Synovitis and tenosynovitis, unspecified (Lower leg)	0.003	0.997	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.003	0.997	0.000
K83.0 Cholangitis	0.000	0.997	0.003
Y54.3 Benzothiadiazine derivatives	0.003	0.997	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.003	0.997	0.000
K30 Dyspepsia	0.000	0.997	0.003
D75.1 Secondary polycythaemia	0.000	0.997	0.003
Y57.7 Vitamins, not elsewhere classified	0.003	0.997	0.000
Y57.4 Pharmaceutical excipients	0.003	0.997	0.000
Y57.3 Alcohol deterrents	0.003	0.997	0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified	0.003	0.997	0.000
Y57.1 Lipotropic drugs	0.003	0.997	0.000
Y57.0 Appetite depressants [anorectics]	0.003	0.997	0.000
Y57.5 X-ray contrast media	0.003	0.997	0.000
D84.8 Other specified immunodeficiencies	0.003	0.997	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.003	0.997	0.000
D60.9 Acquired pure red cell aplasia, unspecified	0.003	0.997	0.000
D60.8 Other acquired pure red cell aplasias	0.003	0.997	0.000
D60.1 Transient acquired pure red cell aplasia	0.003	0.997	0.000
D60.0 Chronic acquired pure red cell aplasia	0.003	0.997	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.003	0.997	0.000
H92.1 Otorrhoea	0.003	0.997	0.000
S22.3 Fracture of rib	0.003	0.997	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.003	0.997	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.003	0.997	0.000
D59 Acquired haemolytic anaemia	0.003	0.997	0.000
D81.9 Combined immunodeficiency, unspecified	0.003	0.997	0.000
D81.8 Other combined immunodeficiencies	0.003	0.997	0.000
D81.7 Major histocompatibility complex class II deficiency	0.003	0.997	0.000
D81.6 Major histocompatibility complex class I deficiency	0.003	0.997	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.003	0.997	0.000
D81.4 Nezelof's syndrome	0.003	0.997	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.003	0.997	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.003	0.997	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.003	0.997	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.003	0.997	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.003	0.997	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.003	0.997	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.003	0.997	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.003	0.997	0.000
D82.2 Immunodeficiency with short-limbed stature	0.003	0.997	0.000
D82.1 Di George's syndrome	0.003	0.997	0.000
D82.0 Wiskott-Aldrich syndrome	0.003	0.997	0.000
D83.9 Common variable immunodeficiency, unspecified	0.003	0.997	0.000
D83.8 Other common variable immunodeficiencies	0.003	0.997	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.003	0.997	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.003	0.997	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.003	0.997	0.000
Y57.8 Other drugs and medicaments	0.002	0.997	0.000
N02.8 Other	0.000	0.997	0.003
K82.3 Fistula of gallbladder	0.001	0.997	0.002
K82.0 Obstruction of gallbladder	0.001	0.997	0.002
D57 Sickle-cell disorders	0.003	0.997	0.000
D56 Thalassaemia	0.003	0.997	0.000
D55 Anaemia due to enzyme disorders	0.003	0.997	0.000
K82.2 Perforation of gallbladder	0.001	0.997	0.002
N02.9 Unspecified	0.000	0.997	0.003
D50.9 Iron deficiency anaemia, unspecified	0.003	0.997	0.000
K82.1 Hydrops of gallbladder	0.001	0.997	0.002
D58 Other hereditary haemolytic anaemias	0.002	0.997	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.002	0.997	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.002	0.997	0.000
D89.3 Immune reconstitution syndrome	0.002	0.997	0.000
D89.1 Cryoglobulinaemia	0.002	0.997	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.002	0.997	0.000
D59.1 Other autoimmune haemolytic anaemias	0.002	0.997	0.000
M48.0 Spinal stenosis	0.000	0.997	0.003
M48.07 Spinal stenosis (Lumbosacral region)	0.000	0.998	0.002
M48.06 Spinal stenosis (Lumbar region)	0.000	0.998	0.002
S22.31 Fracture of rib (open)	0.002	0.998	0.000
D59.8 Other acquired haemolytic anaemias	0.002	0.998	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.002	0.998	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.002	0.998	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.002	0.998	0.000
D59.3 Haemolytic-uraemic syndrome	0.002	0.998	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.002	0.998	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.002	0.998	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.002	0.998	0.000
N02 Recurrent and persistent haematuria	0.000	0.998	0.002
K10.2 Inflammatory conditions of jaws	0.002	0.998	0.000
R40.2 Coma, unspecified	0.000	0.998	0.002
K82.9 Disease of gallbladder, unspecified	0.001	0.998	0.001
Y43 Primarily systemic agents	0.002	0.998	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.002	0.998	0.000
D55.8 Other anaemias due to enzyme disorders	0.002	0.998	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.002	0.998	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.002	0.998	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.002	0.998	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.002	0.998	0.000
D56.9 Thalassaemia, unspecified	0.002	0.998	0.000
D56.8 Other thalassaemias	0.002	0.998	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.002	0.998	0.000
D56.3 Thalassaemia trait	0.002	0.998	0.000
D56.2 Delta-beta thalassaemia	0.002	0.998	0.000
D56.1 Beta thalassaemia	0.002	0.998	0.000
D56.0 Alpha thalassaemia	0.002	0.998	0.000
D57.8 Other sickle-cell disorders	0.002	0.998	0.000
D57.3 Sickle-cell trait	0.002	0.998	0.000
D57.2 Double heterozygous sickling disorders	0.002	0.998	0.000
D57.1 Sickle-cell anaemia without crisis	0.002	0.998	0.000
D57.0 Sickle-cell anaemia with crisis	0.002	0.998	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.002	0.998	0.000
R73.0 Abnormal glucose tolerance test	0.000	0.998	0.002
M65.84 Other synovitis and tenosynovitis (Hand)	0.002	0.998	0.000
S56.4 Injury of extensor muscle and tendon of other finger(s) at forearm level	0.002	0.998	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.002	0.998	0.000
D58.2 Other haemoglobinopathies	0.002	0.998	0.000
D58.1 Hereditary elliptocytosis	0.002	0.998	0.000
K82.4 Cholesterolosis of gallbladder	0.002	0.998	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.002	0.998	0.000
D58.0 Hereditary spherocytosis	0.002	0.998	0.000
D89.2 Hypergammaglobulinaemia, unspecified	0.002	0.998	0.000
Y57.9 Drug or medicament, unspecified	0.002	0.998	0.000
M48.08 Spinal stenosis (Sacral and sacrococcygeal region)	0.000	0.998	0.002
M48.05 Spinal stenosis (Thoracolumbar region)	0.000	0.998	0.002
M48.03 Spinal stenosis (Cervicothoracic region)	0.000	0.998	0.002
M48.01 Spinal stenosis (Occipito-atlanto-axial region)	0.000	0.998	0.002
M65.8 Other synovitis and tenosynovitis	0.002	0.998	0.000
S56 Injury of muscle and tendon at forearm level	0.002	0.998	0.000
I20.1 Angina pectoris with documented spasm	0.002	0.998	0.000
S56.1 Injury of flexor muscle and tendon of other finger(s) at forearm level	0.002	0.998	0.000
M48.04 Spinal stenosis (Thoracic region)	0.000	0.998	0.002
M65.86 Other synovitis and tenosynovitis (Lower leg)	0.002	0.998	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.002	0.998	0.000
K05.3 Chronic periodontitis	0.000	0.998	0.002
S56.3 Injury of extensor or abductor muscles and tendons of thumb at forearm level	0.002	0.998	0.000
N75 Diseases of Bartholin's gland	0.000	0.998	0.002
R32 Unspecified urinary incontinence	0.000	0.998	0.002
B44.1 Other pulmonary aspergillosis	0.002	0.998	0.000
M54.59 Low back pain (Site unspecified)	0.002	0.998	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.002	0.998	0.000
N02.7 Diffuse crescentic glomerulonephritis	0.000	0.998	0.002
N02.6 Dense deposit disease	0.000	0.998	0.002
N02.5 Diffuse mesangiocapillary glomerulonephritis	0.000	0.998	0.002
N02.4 Diffuse endocapillary proliferative glomerulonephritis	0.000	0.998	0.002
N02.3 Diffuse mesangial proliferative glomerulonephritis	0.000	0.998	0.002
N02.2 Diffuse membranous glomerulonephritis	0.000	0.998	0.002
N02.1 Focal and segmental glomerular lesions	0.000	0.998	0.002
N02.0 Minor glomerular abnormality	0.000	0.998	0.002
M65.83 Other synovitis and tenosynovitis (Forearm)	0.002	0.998	0.000
D64 Other anaemias	0.002	0.998	0.000
Y43.9 Primarily systemic agent, unspecified	0.002	0.998	0.000
Y43.8 Other primarily systemic agents, not elsewhere classified	0.002	0.998	0.000
Y43.6 Enzymes, not elsewhere classified	0.002	0.998	0.000
Y43.5 Acidifying and alkalising agents	0.002	0.998	0.000
Y43.2 Antineoplastic natural products	0.002	0.998	0.000
S56.7 Injury of multiple muscles and tendons at forearm level	0.002	0.998	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.002	0.998	0.000
R23.3 Spontaneous ecchymoses	0.002	0.998	0.000
S22 Fracture of rib(s), sternum and thoracic spine	0.002	0.998	0.000
S27.00 Traumatic pneumothorax (without open wound into thoracic cavity)	0.002	0.998	0.000
D67 Hereditary factor IX deficiency	0.002	0.998	0.000
F32.1 Moderate depressive episode	0.002	0.998	0.000
Z93.6 Other artificial openings of urinary tract status	0.000	0.998	0.002
R09.8 Other specified symptoms and signs involving the circulatory and respiratory systems	0.002	0.998	0.000
S22.4 Multiple fractures of ribs	0.002	0.998	0.000
M65.89 Other synovitis and tenosynovitis (Site unspecified)	0.002	0.998	0.000
M65.88 Other synovitis and tenosynovitis (Other)	0.002	0.998	0.000
M65.87 Other synovitis and tenosynovitis (Ankle and foot)	0.002	0.998	0.000
M65.85 Other synovitis and tenosynovitis (Pelvic region and thigh)	0.002	0.998	0.000
M65.82 Other synovitis and tenosynovitis (Upper arm)	0.002	0.998	0.000
M65.81 Other synovitis and tenosynovitis (Shoulder region)	0.002	0.998	0.000
M65.80 Other synovitis and tenosynovitis (Multiple sites)	0.002	0.998	0.000
S27.0 Traumatic pneumothorax	0.002	0.998	0.000
S56.2 Injury of other flexor muscle and tendon at forearm level	0.002	0.998	0.000
S56.5 Injury of other extensor muscle and tendon at forearm level	0.002	0.998	0.000
S56.0 Injury of flexor muscle and tendon of thumb at forearm level	0.002	0.998	0.000
J01.9 Acute sinusitis, unspecified	0.002	0.998	0.000
O26.9 Pregnancy-related condition, unspecified	0.000	0.998	0.002
Y43.0 Antiallergic and antiemetic drugs	0.002	0.998	0.000
M48.00 Spinal stenosis (Multiple sites in spine)	0.000	0.998	0.002
S22.40 Multiple fractures of ribs (closed)	0.002	0.998	0.000
R94.3 Abnormal results of cardiovascular function studies	0.002	0.998	0.000
H92 Otalgia and effusion of ear	0.002	0.998	0.000
M65.99 Synovitis and tenosynovitis, unspecified (Site unspecified)	0.002	0.998	0.000
S27 Injury of other and unspecified intrathoracic organs	0.002	0.998	0.000
S27.10 Traumatic haemothorax (without open wound into thoracic cavity)	0.002	0.998	0.000
S82.20 Fracture of shaft of tibia (closed)	0.002	0.998	0.000
D63.0 Anaemia in neoplastic disease	0.002	0.998	0.000
N75.9 Disease of Bartholin's gland, unspecified	0.000	0.998	0.002
N75.8 Other diseases of Bartholin's gland	0.000	0.998	0.002
S22.5 Flail chest	0.002	0.998	0.000
S27.1 Traumatic haemothorax	0.002	0.998	0.000
N75.1 Abscess of Bartholin's gland	0.000	0.998	0.002
Z85.2 Personal history of malignant neoplasm of other respiratory and intrathoracic organs	0.000	0.998	0.002
D13.1 Stomach	0.000	0.998	0.002
D64.4 Congenital dyserythropoietic anaemia	0.001	0.998	0.000
D64.3 Other sideroblastic anaemias	0.001	0.998	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.001	0.998	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.001	0.998	0.000
D64.0 Hereditary sideroblastic anaemia	0.001	0.998	0.000
S50.0 Contusion of elbow	0.002	0.998	0.000
M65.34 Trigger finger-Hand	0.002	0.998	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.002	0.998	0.000
S27.2 Traumatic heamopneumothorax	0.002	0.998	0.000
R17 Unspecified jaundice	0.000	0.998	0.002
S50 Superficial injury of forearm	0.002	0.998	0.000
S27.20 Traumatic haemopneumothorax (without open wound into thoracic cavity)	0.002	0.998	0.000
M65.3 Trigger finger	0.002	0.998	0.000
S22.9 Fracture of bony thorax, part unspecified	0.001	0.998	0.000
S22.8 Fracture of other parts of bony thorax	0.001	0.998	0.000
S56.8 Injury of other and unspecified muscles and tendons at forearm level	0.001	0.998	0.000
J02 Acute pharyngitis	0.000	0.998	0.001
H66.9 Otitis media, unspecified	0.002	0.998	0.000
R23.1 Pallor	0.002	0.998	0.000
Y43.1 Antineoplastic antimetabolites	0.001	0.998	0.000
M65 Synovitis and tenosynovitis	0.002	0.998	0.000
F20.9 Schizophrenia, unspecified	0.000	0.998	0.002
S22.1 Multiple fractures of thoracic spine	0.001	0.998	0.000
S50.9 Superficial injury of forearm, unspecified	0.002	0.998	0.000
S51 Open wound of forearm	0.002	0.998	0.000
S22.41 Multiple fractures of ribs (open)	0.001	0.998	0.000
S22.50 Flail chest (closed)	0.001	0.998	0.000
D69.4 Other primary thrombocytopenia	0.001	0.998	0.000
F25.9 Schizoaffective disorder, unspecified	0.000	0.998	0.001
S51.8 Open wound of other parts of forearm	0.001	0.998	0.000
D66 Hereditary factor VIII deficiency	0.001	0.998	0.000
S27.01 Traumatic pneumothorax (with open wound into thoracic cavity)	0.001	0.998	0.000
S56.20 Unspecified injury of other flexor muscle, fascia and tendon at forearm level	0.001	0.998	0.000
S51.7 Multiple open wounds of forearm	0.001	0.998	0.000
H92.2 Otorrhagia	0.001	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations