TreeWAS – Variant ID: rs199515

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
K60.2 Anal fissure, unspecified	0.000	0.074	0.926
K60.1 Chronic anal fissure	0.000	0.099	0.901
K60 Fissure and fistula of anal and rectal regions	0.000	0.101	0.899
E66.8 Other obesity	0.000	0.142	0.858
E66.9 Obesity, unspecified	0.000	0.146	0.854
E66 Obesity	0.000	0.146	0.854
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.812	0.188	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.810	0.190	0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.805	0.195	0.000
M20 Acquired deformities of fingers and toes	0.000	0.204	0.796
M20.2 Hallux rigidus	0.000	0.207	0.793
M20.5 Other deformities of toe(s) (acquired)	0.000	0.213	0.787
M20.1 Hallux valgus (acquired)	0.000	0.217	0.783
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.766	0.234	0.000
M20.3 Other deformity of hallux (acquired)	0.000	0.249	0.751
C88 Malignant immunoproliferative diseases	0.747	0.253	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.744	0.256	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.732	0.268	0.000
C85.1 B-cell lymphoma, unspecified	0.702	0.298	0.000
C90 Multiple myeloma and malignant plasma cell neoplasms	0.693	0.307	0.000
C83.3 Large cell (diffuse)	0.692	0.308	0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.688	0.312	0.000
C88.0 Waldenstrom's macroglobulinaemia	0.683	0.317	0.000
M20.0 Deformity of finger(s)	0.000	0.343	0.657
C93 Monocytic leukaemia	0.657	0.343	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.646	0.354	0.000
K60.4 Rectal fistula	0.000	0.360	0.639
C82.2 Large cell, follicular	0.636	0.364	0.000
C95 Leukaemia of unspecified cell type	0.635	0.364	0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma	0.631	0.369	0.000
C84.5 Other and unspecified T-cell lymphomas	0.629	0.371	0.000
C91 Lymphoid leukaemia	0.620	0.380	0.000
C86 Other specified types of T/NK-cell lymphoma	0.619	0.381	0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma	0.615	0.385	0.000
C84.4 Peripheral T-cell lymphoma	0.615	0.385	0.000
E66.1 Drug-induced obesity	0.000	0.388	0.612
E65-E68 Obesity and other hyperalimentation	0.000	0.405	0.595
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]	0.592	0.408	0.000
M16.9 Coxarthrosis, unspecified	0.000	0.408	0.592
M16.1 Other primary coxarthrosis	0.000	0.410	0.590
C90.0 Multiple myeloma	0.588	0.412	0.000
M16 Coxarthrosis [arthrosis of hip]	0.000	0.412	0.588
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.582	0.417	0.000
C92 Myeloid leukaemia	0.582	0.418	0.000
C82.0 Small cleaved cell, follicular	0.581	0.419	0.000
C85.0 Lymphosarcoma	0.581	0.419	0.000
C90.3 Solitary plasmacytoma	0.575	0.425	0.000
E66.0 Obesity due to excess calories	0.000	0.430	0.570
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.446	0.554
C83.5 Lymphoblastic (diffuse)	0.551	0.449	0.000
C94 Other leukaemias of specified cell type	0.550	0.450	0.000
C82.6 Cutaneous follicle centre lymphoma	0.549	0.451	0.000
C82.5 Diffuse follicle centre lymphoma	0.549	0.451	0.000
M16.3 Other dysplastic coxarthrosis	0.000	0.454	0.546
C93.1 Chronic monocytic leukaemia	0.545	0.455	0.000
C83.2 Mixed small and large cell (diffuse)	0.543	0.457	0.000
C83.1 Small cleaved cell (diffuse)	0.542	0.458	0.000
C84.8 Cutaneous T-cell lymphoma, unspecified	0.541	0.459	0.000
K60.3 Anal fistula	0.000	0.460	0.540
C95.9 Leukaemia, unspecified	0.538	0.462	0.000
C85.7 Other specified types of non-Hodgkin's lymphoma	0.536	0.464	0.000
C83.7 Burkitt's tumour	0.536	0.464	0.000
C88.9 Malignant immunoproliferative disease, unspecified	0.535	0.464	0.000
C88.7 Other malignant immunoproliferative diseases	0.535	0.464	0.000
C88.3 Immunoproliferative small intestinal disease	0.535	0.464	0.000
C88.2 Gamma heavy chain disease	0.535	0.464	0.000
C88.1 Alpha heavy chain disease	0.535	0.464	0.000
C83.6 Undifferentiated (diffuse)	0.534	0.466	0.000
C83.4 Immunoblastic (diffuse)	0.534	0.466	0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.527	0.473	0.000
C84.9 Mature T/NK-cell lymphoma, unspecified	0.525	0.475	0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative	0.525	0.475	0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive	0.525	0.475	0.000
C84.3 Lymphoepithelioid lymphoma	0.525	0.475	0.000
C84.2 T-zone lymphoma	0.525	0.475	0.000
C84.1 Sezary's diease	0.525	0.475	0.000
C82.3 Follicular lymphoma grade IIIa	0.514	0.486	0.000
K60.0 Acute anal fissure	0.000	0.487	0.512
C84.0 Mycosis fungoides	0.512	0.488	0.000
C91.0 Acute lymphoblastic leukaemia	0.512	0.488	0.000
C82.4 Follicular lymphoma grade IIIb	0.511	0.489	0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified	0.502	0.498	0.000
C81 Hodgkin's disease	0.500	0.500	0.000
C90.1 Plasma cell leukaemia	0.486	0.514	0.000
C92.7 Other myeloid leukaemia	0.484	0.516	0.000
C91.4 Hairy-cell leukaemia	0.483	0.517	0.000
C86.5 Angioimmunoblastic T-cell lymphoma	0.480	0.520	0.000
E20-E35 Disorders of other endocrine glands	0.000	0.524	0.476
E22 Hyperfunction of pituitary gland	0.000	0.526	0.474
C93.9 Monocytic leukaemia, unspecified	0.471	0.529	0.000
C93.7 Other monocytic leukaemia	0.471	0.529	0.000
C93.3 Juvenile myelomonocytic leukaemia	0.471	0.529	0.000
C93.2 Subacute monocytic leukaemia	0.471	0.529	0.000
C93.0 Acute monocytic leukaemia	0.471	0.529	0.000
C91.1 Chronic lymphocytic leukaemia	0.459	0.541	0.000
C95.7 Other leukaemia of unspecified cell type	0.456	0.544	0.000
C95.2 Subacute leukaemia of unspecified cell type	0.456	0.544	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.547	0.453
E22.0 Acromegaly and pituitary gigantism	0.000	0.549	0.451
C91.8 Mature B-cell leukaemia Burkitt-type	0.445	0.555	0.000
C91.7 Other lymphoid leukaemia	0.445	0.555	0.000
C91.6 Prolymphocytic leukaemia of T-cell type	0.445	0.555	0.000
C91.3 Prolymphocytic leukaemia	0.445	0.555	0.000
C91.2 Subacute lymphocytic leukaemia	0.445	0.555	0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations	0.444	0.556	0.000
C86.4 Blastic NK-cell lymphoma	0.444	0.556	0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma	0.444	0.556	0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma	0.444	0.556	0.000
C86.1 Hepatosplenic T-cell lymphoma	0.444	0.556	0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type	0.444	0.556	0.000
C90.2 Plasmacytoma, extramedullary	0.443	0.557	0.000
K60.5 Anorectal fistula	0.000	0.559	0.441
E29 Testicular dysfunction	0.000	0.561	0.439
E34 Other endocrine disorders	0.000	0.563	0.437
C92.4 Acute promyelocytic leukaemia	0.436	0.564	0.000
C95.0 Acute leukaemia of unspecified cell type	0.436	0.564	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.000	0.566	0.434
E24 Cushing's syndrome	0.000	0.567	0.433
E26 Hyperaldosteronism	0.000	0.571	0.429
C92.5 Acute myelomonocytic leukaemia	0.429	0.571	0.000
M16.7 Other secondary coxarthrosis	0.000	0.573	0.427
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.000	0.573	0.427
E67 Other hyperalimentation	0.000	0.573	0.427
E68 Sequelae of hyperalimentation	0.000	0.573	0.427
C91.5 Adult T-cell leukaemia	0.425	0.575	0.000
C92.2 Subacute myeloid leukaemia	0.425	0.575	0.000
C95.1 Chronic leukaemia of unspecified cell type	0.424	0.576	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.000	0.579	0.421
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified	0.418	0.582	0.000
C96.8 Histiocytic sarcoma	0.418	0.582	0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.418	0.582	0.000
C96.6 Unifocal Langerhans-cell histiocytosis	0.418	0.582	0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis	0.418	0.582	0.000
C96.4 Sarcoma of dendritic cells (accessory cells)	0.418	0.582	0.000
C96.3 True histiocytic lymphoma	0.418	0.582	0.000
C96.2 Malignant mast cell tumour	0.418	0.582	0.000
C96.1 Malignant histiocytosis	0.418	0.582	0.000
C96.0 Letterer-Siwe disease	0.418	0.582	0.000
E29.1 Testicular hypofunction	0.000	0.583	0.417
C92.8 Acute myeloid leukaemia with multilineage dysplasia	0.417	0.583	0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality	0.417	0.583	0.000
C92.3 Myeloid sarcoma	0.417	0.583	0.000
C92.1 Chronic myeloid leukaemia	0.414	0.586	0.000
E22.1 Hyperprolactinaemia	0.000	0.597	0.403
C94.7 Other specified leukaemias	0.394	0.606	0.000
C94.5 Acute myelofibrosis	0.394	0.606	0.000
C94.3 Mast cell leukaemia	0.394	0.606	0.000
C94.2 Acute megakaryoblastic leukaemia	0.394	0.606	0.000
C94.1 Chronic erythraemia	0.394	0.606	0.000
C94.0 Acute erythraemia and erythroleukaemia	0.394	0.606	0.000
E26.0 Primary hyperaldosteronism	0.000	0.610	0.390
M16.6 Other secondary coxarthrosis, bilateral	0.000	0.612	0.388
C81.2 Mixed cellularity	0.385	0.614	0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified	0.382	0.618	0.000
E34.0 Carcinoid syndrome	0.000	0.619	0.381
C92.9 Myeloid leukaemia, unspecified	0.377	0.623	0.000
C94.4 Acute panmyelosis	0.375	0.624	0.000
E65 Localised adiposity	0.000	0.625	0.375
M15-M19 Arthrosis	0.000	0.631	0.369
M18 Arthrosis of first carpometacarpal joint	0.000	0.635	0.365
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.637	0.363
E24.9 Cushing's syndrome, unspecified	0.000	0.638	0.362
C81.4 Lymphocyte-rich classical Hodgkin lymphoma	0.358	0.641	0.000
C81.3 Lymphocytic depletion	0.358	0.641	0.000
C83.0 Small cell (diffuse)	0.358	0.642	0.000
C81.1 Nodular sclerosis	0.357	0.642	0.000
E24.0 Pituitary-dependent Cushing's disease	0.000	0.643	0.357
E34.3 Short stature, not elsewhere classified	0.000	0.643	0.357
E34.9 Endocrine disorder, unspecified	0.000	0.644	0.356
E23 Hypofunction and other disorders of pituitary gland	0.000	0.651	0.349
C81.9 Hodgkin's disease, unspecified	0.346	0.654	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.000	0.654	0.346
M16.5 Other posttraumatic coxarthrosis	0.000	0.655	0.345
C91.9 Lymphoid leukaemia, unspecified	0.342	0.658	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.659	0.341
E30 Disorders of puberty, not elsewhere classified	0.000	0.659	0.341
E24.2 Drug-induced Cushing's syndrome	0.000	0.660	0.340
E22.8 Other hyperfunction of pituitary gland	0.000	0.660	0.340
M18.9 Arthrosis of first carpometacarpal joint, unspecified	0.000	0.664	0.336
E25 Adrenogenital disorders	0.000	0.669	0.330
E31 Polyglandular dysfunction	0.000	0.673	0.327
E26.9 Hyperaldosteronism, unspecified	0.000	0.677	0.323
E20 Hypoparathyroidism	0.000	0.677	0.323
E24.8 Other Cushing's syndrome	0.000	0.680	0.320
E40-E46 Malnutrition	0.000	0.684	0.316
E32 Diseases of thymus	0.000	0.684	0.316
E29.8 Other testicular dysfunction	0.000	0.685	0.315
E29.0 Testicular hyperfunction	0.000	0.685	0.315
E34.5 Androgen resistance syndrome	0.000	0.687	0.313
E34.4 Constitutional tall stature	0.000	0.687	0.313
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.687	0.313
E34.1 Other hypersecretion of intestinal hormones	0.000	0.687	0.313
C81.7 Other Hodgkin's disease	0.313	0.687	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.689	0.310
E24.3 Ectopic ACTH syndrome	0.000	0.689	0.310
E24.1 Nelson's syndrome	0.000	0.689	0.310
C81.0 Lymphocytic predominance	0.308	0.692	0.000
E26.8 Other hyperaldosteronism	0.000	0.692	0.307
E26.1 Secondary hyperaldosteronism	0.000	0.692	0.307
E67.8 Other specified hyperalimentation	0.000	0.694	0.306
E67.3 Hypervitaminosis D	0.000	0.694	0.306
E67.2 Megavitamin-B6 syndrome	0.000	0.694	0.306
E67.1 Hypercarotenaemia	0.000	0.694	0.306
E67.0 Hypervitaminosis A	0.000	0.694	0.306
C92.0 Acute myeloid leukaemia	0.298	0.701	0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral	0.000	0.704	0.296
E29.9 Testicular dysfunction, unspecified	0.000	0.709	0.291
E34.8 Other specified endocrine disorders	0.000	0.709	0.291
E00-E07 Disorders of thyroid gland	0.000	0.712	0.288
M20.6 Acquired deformity of toe(s), unspecified	0.000	0.722	0.277
E23.2 Diabetes insipidus	0.000	0.724	0.276
E06 Thyroiditis	0.000	0.727	0.273
E27 Other disorders of adrenal gland	0.000	0.730	0.270
M18.5 Other secondary arthrosis of first carpometacarpal joint	0.000	0.738	0.262
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral	0.000	0.738	0.262
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral	0.000	0.738	0.262
E07 Other disorders of thyroid	0.000	0.738	0.262
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.000	0.738	0.262
E06.3 Autoimmune thyroiditis	0.000	0.739	0.261
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint	0.000	0.739	0.261
E23.1 Drug-induced hypopituitarism	0.000	0.750	0.250
E23.0 Hypopituitarism	0.000	0.752	0.248
E07.9 Disorder of thyroid, unspecified	0.000	0.753	0.247
E23.6 Other disorders of pituitary gland	0.000	0.754	0.246
E30.9 Disorder of puberty, unspecified	0.000	0.755	0.245
E30.8 Other disorders of puberty	0.000	0.755	0.245
E30.1 Precocious puberty	0.000	0.755	0.245
E30.0 Delayed puberty	0.000	0.755	0.245
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.755	0.245
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.755	0.245
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.755	0.245
E50-E64 Other nutritional deficiencies	0.000	0.756	0.243
M20.4 Other hammer toe(s) (acquired)	0.000	0.757	0.243
E20.9 Hypoparathyroidism, unspecified	0.000	0.762	0.238
E25.9 Adrenogenital disorder, unspecified	0.000	0.763	0.237
E25.8 Other adrenogenital disorders	0.000	0.763	0.237
E31.9 Polyglandular dysfunction, unspecified	0.000	0.765	0.234
E31.8 Other polyglandular dysfunction	0.000	0.765	0.234
E31.1 Polyglandular hyperfunction	0.000	0.765	0.234
E20.0 Idiopathic hypoparathyroidism	0.000	0.768	0.232
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.773	0.227
E45 Retarded development following protein-energy malnutrition	0.000	0.773	0.227
E43 Unspecified severe protein-energy malnutrition	0.000	0.773	0.227
E42 Marasmic kwashiorkor	0.000	0.773	0.227
E41 Nutritional marasmus	0.000	0.773	0.227
E40 Kwashiorkor	0.000	0.773	0.227
E32.1 Abscess of thymus	0.000	0.773	0.227
E32.0 Persistent hyperplasia of thymus	0.000	0.773	0.227
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.773	0.227
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.000	0.773	0.226
E20.8 Other hypoparathyroidism	0.000	0.776	0.224
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.777	0.223
E31.0 Autoimmune polyglandular failure	0.000	0.779	0.220
E32.9 Disease of thymus, unspecified	0.000	0.780	0.219
E23.7 Disorder of pituitary gland, unspecified	0.000	0.782	0.218
E46 Unspecified protein-energy malnutrition	0.000	0.782	0.218
E20.1 Pseudohypoparathyroidism	0.000	0.785	0.214
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.786	0.214
E32.8 Other diseases of thymus	0.000	0.790	0.210
E61 Deficiency of other nutrient elements	0.000	0.790	0.210
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.793	0.207
E00 Congenital iodine-deficiency syndrome	0.000	0.793	0.207
E06.9 Thyroiditis, unspecified	0.000	0.794	0.206
E06.1 Subacute thyroiditis	0.000	0.801	0.199
E06.4 Drug-induced thyroiditis	0.000	0.804	0.196
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.804	0.196
E06.0 Acute thyroiditis	0.000	0.804	0.196
E27.5 Adrenomedullary hyperfunction	0.000	0.806	0.194
E27.0 Other adrenocortical overactivity	0.000	0.806	0.194
E06.5 Other chronic thyroiditis	0.000	0.808	0.192
E28 Ovarian dysfunction	0.001	0.809	0.191
E27.2 Addisonian crisis	0.000	0.812	0.188
E07.1 Dyshormogenetic goitre	0.000	0.812	0.188
E07.0 Hypersecretion of calcitonin	0.000	0.812	0.188
E61.1 Iron deficiency	0.000	0.818	0.182
E54 Ascorbic acid deficiency	0.000	0.819	0.181
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.825	0.175
E50 Vitamin A deficiency	0.000	0.825	0.175
E60 Dietary zinc deficiency	0.000	0.825	0.175
E59 Dietary selenium deficiency	0.000	0.825	0.175
E52 Niacin deficiency [pellagra]	0.000	0.825	0.175
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.826	0.174
E63 Other nutritional deficiencies	0.000	0.831	0.169
E07.8 Other specified disorders of thyroid	0.000	0.832	0.168
M19 Other arthrosis	0.000	0.832	0.168
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.835	0.165
E56 Other vitamin deficiencies	0.000	0.835	0.165
E51 Thiamine deficiency	0.000	0.837	0.163
E44.1 Mild protein-energy malnutrition	0.000	0.837	0.163
E44.0 Moderate protein-energy malnutrition	0.000	0.837	0.163
E15 Nondiabetic hypoglycaemic coma	0.000	0.837	0.163
E58 Dietary calcium deficiency	0.000	0.840	0.160
E61.2 Magnesium deficiency	0.000	0.841	0.159
E27.8 Other specified disorders of adrenal gland	0.000	0.844	0.156
E27.9 Disorder of adrenal gland, unspecified	0.000	0.846	0.153
E61.9 Deficiency of nutrient element, unspecified	0.000	0.849	0.151
E61.8 Deficiency of other specified nutrient elements	0.000	0.849	0.151
E61.7 Deficiency of multiple nutrient elements	0.000	0.849	0.151
E61.6 Vanadium deficiency	0.000	0.849	0.151
E61.5 Molybdenum deficiency	0.000	0.849	0.151
E61.4 Chromium deficiency	0.000	0.849	0.151
E61.3 Manganese deficiency	0.000	0.849	0.151
E61.0 Copper deficiency	0.000	0.849	0.151
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.851	0.148
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.851	0.148
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.851	0.148
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.851	0.148
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.851	0.148
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.851	0.148
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.851	0.148
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.851	0.148
M17 Gonarthrosis [arthrosis of knee]	0.000	0.853	0.147
M19.0 Primary arthrosis of other joints	0.000	0.853	0.147
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.000	0.855	0.145
E53 Deficiency of other B group vitamins	0.000	0.860	0.140
E27.1 Primary adrenocortical insufficiency	0.000	0.862	0.138
E28.9 Ovarian dysfunction, unspecified	0.001	0.863	0.137
E28.8 Other ovarian dysfunction	0.001	0.863	0.137
E28.1 Androgen excess	0.001	0.863	0.137
E28.0 Oestrogen excess	0.001	0.863	0.137
M17.5 Other secondary gonarthrosis	0.000	0.863	0.137
E03 Other hypothyroidism	0.000	0.866	0.134
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.872	0.128
E21.4 Other specified disorders of parathyroid gland	0.000	0.873	0.127
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.873	0.127
M17.3 Other posttraumatic gonarthrosis	0.000	0.874	0.126
E50.9 Vitamin A deficiency, unspecified	0.000	0.874	0.125
E50.8 Other manifestations of vitamin A deficiency	0.000	0.874	0.125
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.874	0.125
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.874	0.125
E50.5 Vitamin A deficiency with night blindness	0.000	0.874	0.125
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.874	0.125
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.874	0.125
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.874	0.125
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.874	0.125
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.874	0.125
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.874	0.125
E64.8 Sequelae of other nutritional deficiencies	0.000	0.874	0.125
E64.3 Sequelae of rickets	0.000	0.874	0.125
E64.2 Sequelae of vitamin C deficiency	0.000	0.874	0.125
E64.1 Sequelae of vitamin A deficiency	0.000	0.874	0.125
E64.0 Sequelae of protein-energy malnutrition	0.000	0.874	0.125
E63.8 Other specified nutritional deficiencies	0.000	0.878	0.121
E63.1 Imbalance of constituents of food intake	0.000	0.878	0.121
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.878	0.121
M19.8 Other specified arthrosis	0.000	0.879	0.121
E56.9 Vitamin deficiency, unspecified	0.000	0.881	0.118
E56.8 Deficiency of other vitamins	0.000	0.881	0.118
E56.0 Deficiency of vitamin E	0.000	0.881	0.118
M19.00 Primary arthrosis of other joints (Multiple sites)	0.000	0.882	0.118
M17.2 Posttraumatic gonarthrosis, bilateral	0.000	0.882	0.118
E51.9 Thiamine deficiency, unspecified	0.000	0.883	0.117
E51.8 Other manifestations of thiamine deficiency	0.000	0.883	0.117
E51.1 Beriberi	0.000	0.883	0.117
M19.08 Primary arthrosis of other joints (Other)	0.000	0.884	0.116
E63.9 Nutritional deficiency, unspecified	0.000	0.884	0.116
E55 Vitamin D deficiency	0.000	0.884	0.115
E53.9 Vitamin B deficiency, unspecified	0.000	0.886	0.114
E28.3 Primary ovarian failure	0.001	0.890	0.110
E56.1 Deficiency of vitamin K	0.000	0.891	0.108
M15 Polyarthrosis	0.001	0.891	0.108
M19.2 Other secondary arthrosis	0.000	0.893	0.107
E21.2 Other hyperparathyroidism	0.000	0.894	0.106
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)	0.000	0.894	0.106
E51.2 Wernicke's encephalopathy	0.000	0.895	0.105
E21.0 Primary hyperparathyroidism	0.000	0.897	0.103
M19.03 Primary arthrosis of other joints (Forearm)	0.000	0.897	0.103
M17.4 Other secondary gonarthrosis, bilateral	0.000	0.897	0.103
M19.04 Primary arthrosis of other joints (Hand)	0.000	0.898	0.102
M20-M25 Other joint disorders	0.000	0.898	0.102
E53.1 Pyridoxine deficiency	0.000	0.899	0.100
E53.0 Riboflavin deficiency	0.000	0.899	0.100
M31 Other necrotising vasculopathies	0.000	0.901	0.099
M16.0 Primary coxarthrosis, bilateral	0.000	0.904	0.096
E03.5 Myxoedema coma	0.000	0.904	0.096
E03.4 Atrophy of thyroid (acquired)	0.000	0.904	0.096
E03.3 Postinfectious hypothyroidism	0.000	0.904	0.096
M19.09 Primary arthrosis of other joints (Site unspecified)	0.000	0.905	0.095
M19.02 Primary arthrosis of other joints (Upper arm)	0.000	0.906	0.093
M19.84 Other specified arthrosis (Hand)	0.000	0.907	0.093
M19.1 Posttraumatic arthrosis of other joints	0.000	0.907	0.092
E03.1 Congenital hypothyroidism without goitre	0.000	0.908	0.092
M31.3 Wegener's granulomatosis	0.000	0.909	0.091
E03.8 Other specified hypothyroidism	0.000	0.910	0.090
M19.06 Primary arthrosis of other joints-Lower leg	0.000	0.911	0.089
M19.88 Other specified arthrosis (Other)	0.000	0.912	0.087
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.912	0.087
M19.86 Other specified arthrosis (Lower leg)	0.000	0.913	0.087
M19.85 Other specified arthrosis (Pelvic region and thigh)	0.000	0.913	0.087
M19.83 Other specified arthrosis (Forearm)	0.000	0.913	0.087
M19.82 Other specified arthrosis (Upper arm)	0.000	0.913	0.087
M19.81 Other specified arthrosis (Shoulder region)	0.000	0.913	0.087
M19.80 Other specified arthrosis (Multiple sites)	0.000	0.913	0.087
M31.6 Other giant cell arteritis	0.000	0.913	0.087
M19.87 Other specified arthrosis (Ankle and foot)	0.000	0.913	0.086
M21 Other acquired deformities of limbs	0.000	0.914	0.086
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.916	0.084
E55.0 Rickets, active	0.000	0.917	0.083
M19.17 Post-traumatic arthrosis of other joints (Ankle and foot)	0.000	0.917	0.083
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.000	0.919	0.081
M19.89 Other specified arthrosis (Site unspecified)	0.000	0.919	0.081
M21.1 Varus deformity, not elsewhere classified	0.000	0.919	0.081
E03.9 Hypothyroidism, unspecified	0.000	0.920	0.080
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.000	0.920	0.080
M15.0 Primary generalised (osteo)arthrosis	0.001	0.920	0.079
M33 Dermatopolymyositis	0.000	0.920	0.080
M19.29 Other secondary arthrosis (Site unspecified)	0.000	0.923	0.077
M19.28 Other secondary arthrosis (Other)	0.000	0.923	0.077
M19.26 Other secondary arthrosis of other joints-Lower leg	0.000	0.923	0.077
M19.25 Other secondary arthrosis (Pelvic region and thigh)	0.000	0.923	0.077
M19.24 Other secondary arthrosis (Hand)	0.000	0.923	0.077
M19.22 Other secondary arthrosis (Upper arm)	0.000	0.923	0.077
M19.20 Other secondary arthrosis (Multiple sites)	0.000	0.923	0.077
M31.0 Hypersensitivity angiitis	0.000	0.924	0.075
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.000	0.925	0.075
M19.27 Other secondary arthrosis (Ankle and foot)	0.000	0.926	0.074
M19.21 Other secondary arthrosis (Shoulder region)	0.000	0.926	0.074
M15.9 Polyarthrosis, unspecified	0.001	0.926	0.073
M21.0 Valgus deformity, not elsewhere classified	0.000	0.927	0.073
M15.8 Other polyarthrosis	0.001	0.927	0.072
M19.23 Other secondary arthrosis (Forearm)	0.000	0.928	0.071
M65-M68 Disorders of synovium and tendon	0.000	0.928	0.072
M31.2 Lethal midline granuloma	0.000	0.929	0.071
M31.4 Aortic arch syndrome [Takayasu]	0.000	0.929	0.071
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.000	0.930	0.070
M67 Other disorders of synovium and tendon	0.000	0.930	0.070
M31.1 Thrombotic microangiopathy	0.000	0.930	0.069
M67.1 Other contracture of tendon (sheath)	0.000	0.931	0.069
M15.3 Secondary multiple arthrosis	0.001	0.931	0.068
M33.1 Other dermatomyositis	0.000	0.932	0.068
M31.8 Other specified necrotising vasculopathies	0.000	0.932	0.068
M31.7 Microscopic polyangiitis	0.000	0.932	0.068
M15.4 Erosive (osteo)arthrosis	0.001	0.933	0.066
M31.9 Necrotising vasculopathy, unspecified	0.000	0.933	0.067
M19.19 Post-traumatic arthrosis of other joints (Site unspecified)	0.000	0.933	0.066
M19.18 Post-traumatic arthrosis of other joints (Other)	0.000	0.933	0.066
M19.15 Post-traumatic arthrosis of other joints (Pelvic region and thigh)	0.000	0.933	0.066
M19.10 Post-traumatic arthrosis of other joints (Multiple sites)	0.000	0.933	0.066
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.000	0.934	0.066
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.000	0.934	0.066
M32 Systemic lupus erythematosus	0.000	0.934	0.066
M91-M94 Chondropathies	0.000	0.934	0.065
M21.7 Unequal limb length (acquired)	0.000	0.935	0.065
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.000	0.935	0.065
E04 Other non-toxic goitre	0.000	0.935	0.065
E16 Other disorders of pancreatic internal secretion	0.000	0.936	0.064
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.000	0.936	0.064
M15.1 Heberden's nodes (with arthropathy)	0.001	0.936	0.063
M19.14 Post-traumatic arthrosis of other joints (Hand)	0.000	0.937	0.062
M19.16 Post-traumatic arthrosis of other joints-Lower leg	0.000	0.938	0.062
M19.12 Post-traumatic arthrosis of other joints (Upper arm)	0.000	0.939	0.061
M67.2 Synovial hypertrophy, not elsewhere classified	0.000	0.940	0.060
M15.00 Primary generalized (osteo)arthrosis, Multiple sites	0.001	0.941	0.059
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.941	0.059
M86-M90 Other osteopathies	0.000	0.941	0.059
M21.6 Other acquired deformities of ankle and foot	0.000	0.942	0.058
M21.9 Acquired deformity of limb, unspecified	0.000	0.942	0.058
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.000	0.942	0.058
M21.18 Varus deformity, not elsewhere classified (Other)	0.000	0.942	0.058
M21.14 Varus deformity, not elsewhere classified (Hand)	0.000	0.942	0.058
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.000	0.942	0.058
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.000	0.942	0.058
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.000	0.942	0.058
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.000	0.942	0.058
M33.9 Dermatopolymyositis, unspecified	0.000	0.943	0.057
M33.0 Juvenile dermatomyositis	0.000	0.943	0.057
M22 Disorders of patella	0.000	0.944	0.056
E28.2 Polycystic ovarian syndrome	0.001	0.944	0.055
M67.4 Ganglion	0.000	0.945	0.055
M66 Spontaneous rupture of synovium and tendon	0.000	0.946	0.054
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.000	0.947	0.053
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.000	0.947	0.053
M94 Other disorders of cartilage	0.000	0.947	0.053
M32.8 Other forms of systemic lupus erythematosus	0.000	0.947	0.053
M21.2 Flexion deformity	0.000	0.947	0.053
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.000	0.947	0.052
M21.08 Valgus deformity, not elsewhere classified (Other)	0.000	0.947	0.052
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.000	0.947	0.052
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.000	0.947	0.052
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.000	0.947	0.052
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.000	0.947	0.052
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.000	0.947	0.052
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.000	0.947	0.052
M21.3 Wrist or foot drop (acquired)	0.000	0.948	0.052
M67.0 Short Achilles tendon (acquired)	0.000	0.948	0.052
E21.3 Hyperparathyroidism, unspecified	0.000	0.948	0.052
M15.2 Bouchard's nodes (with arthropathy)	0.001	0.948	0.051
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.000	0.948	0.051
M92 Other juvenile osteochondrosis	0.000	0.949	0.051
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.000	0.949	0.051
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.000	0.949	0.051
M89 Other disorders of bone	0.000	0.949	0.051
M89.8 Other specified disorders of bone	0.000	0.949	0.051
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.000	0.949	0.050
M36.3 Arthropathy in other blood disorders	0.000	0.949	0.050
M36.2 Haemophilic arthropathy	0.000	0.949	0.050
M36.1 Arthropathy in neoplastic disease	0.000	0.949	0.050
M36.0 Dermato(poly)myositis in neoplastic disease	0.000	0.949	0.050
M21.76 Unequal limb length (acquired) (Lower leg)	0.000	0.949	0.050
M19.13 Post-traumatic arthrosis of other joints (Forearm)	0.001	0.950	0.050

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations