TreeWAS – Variant ID: rs2048161

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I51.7 Cardiomegaly	0.026	0.974	0.000
I51.8 Other ill-defined heart diseases	0.023	0.977	0.000
I51 Complications and ill-defined descriptions of heart disease	0.023	0.977	0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.019	0.981	0.000
I51.6 Cardiovascular disease, unspecified	0.019	0.981	0.000
I51.0 Cardiac septal defect, acquired	0.017	0.983	0.000
M20-M25 Other joint disorders	0.017	0.983	0.000
M34 Systemic sclerosis	0.017	0.983	0.000
I51.2 Rupture of papillary muscle, not elsewhere classified	0.017	0.983	0.000
M21 Other acquired deformities of limbs	0.017	0.983	0.000
M25 Other joint disorders, not elsewhere classified	0.017	0.983	0.000
I51.4 Myocarditis, unspecified	0.016	0.984	0.000
I49.5 Sick sinus syndrome	0.016	0.984	0.000
I51.5 Myocardial degeneration	0.015	0.984	0.000
I49 Other cardiac arrhythmias	0.015	0.985	0.000
M22 Disorders of patella	0.015	0.985	0.000
I51.3 Intracardiac thrombosis, not elsewhere classified	0.015	0.985	0.000
M34.9 Systemic sclerosis, unspecified	0.015	0.985	0.000
M21.2 Flexion deformity	0.015	0.985	0.000
M34.1 CR(E)ST syndrome	0.015	0.985	0.000
I49.8 Other specified cardiac arrhythmias	0.015	0.985	0.000
M25.8 Other specified joint disorders	0.015	0.985	0.000
M33 Dermatopolymyositis	0.015	0.985	0.000
M25.0 Haemarthrosis	0.014	0.986	0.000
M21.1 Varus deformity, not elsewhere classified	0.014	0.986	0.000
M25.5 Pain in joint	0.014	0.986	0.000
M34.8 Other forms of systemic sclerosis	0.014	0.986	0.000
R23.3 Spontaneous ecchymoses	0.000	0.986	0.014
M20.2 Hallux rigidus	0.014	0.986	0.000
M22.3 Other derangements of patella	0.014	0.986	0.000
M20.6 Acquired deformity of toe(s), unspecified	0.014	0.986	0.000
M22.4 Chondromalacia patellae	0.014	0.986	0.000
M20 Acquired deformities of fingers and toes	0.014	0.986	0.000
M21.7 Unequal limb length (acquired)	0.013	0.986	0.000
I49.1 Atrial premature depolarisation	0.013	0.987	0.000
M25.50 Pain in joint (Multiple sites)	0.013	0.987	0.000
M21.9 Acquired deformity of limb, unspecified	0.013	0.987	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.013	0.987	0.000
M24 Other specific joint derangements	0.013	0.987	0.000
M35 Other systemic involvement of connective tissue	0.013	0.987	0.000
M33.2 Polymyositis	0.013	0.987	0.000
M25.53 Pain in joint (Forearm)	0.013	0.987	0.000
M25.9 Joint disorder, unspecified	0.013	0.987	0.000
M25.06 Haemarthrosis (Lower leg)	0.013	0.987	0.000
M21.6 Other acquired deformities of ankle and foot	0.013	0.987	0.000
M21.26 Flexion deformity (Lower leg)	0.013	0.987	0.000
M21.3 Wrist or foot drop (acquired)	0.013	0.987	0.000
M21.4 Flat foot [pes planus] (acquired)	0.013	0.987	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.012	0.987	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.012	0.987	0.000
M25.87 Other specified joint disorders (Ankle and foot)	0.012	0.988	0.000
M32 Systemic lupus erythematosus	0.012	0.988	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.012	0.988	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.012	0.988	0.000
M25.86 Other specified joint disorders (Lower leg)	0.012	0.988	0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.012	0.988	0.000
M25.2 Flail joint	0.012	0.988	0.000
M25.1 Fistula of joint	0.012	0.988	0.000
R23 Other skin changes	0.000	0.988	0.012
M21.24 Flexion deformity (Hand)	0.012	0.988	0.000
M34.0 Progressive systemic sclerosis	0.012	0.988	0.000
M25.3 Other instability of joint	0.012	0.988	0.000
I30-I52 Other forms of heart disease	0.012	0.988	0.000
R23.4 Changes in skin texture	0.000	0.988	0.012
I49.3 Ventricular premature depolarisation	0.012	0.988	0.000
M22.9 Disorder of patella, unspecified	0.012	0.988	0.000
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.011	0.989	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.011	0.989	0.000
M21.25 Flexion deformity (Pelvic region and thigh)	0.011	0.989	0.000
M35.3 Polymyalgia rheumatica	0.011	0.989	0.000
M22.0 Recurrent dislocation of patella	0.011	0.989	0.000
M25.83 Other specified joint disorders (Forearm)	0.011	0.989	0.000
M25.7 Osteophyte	0.011	0.989	0.000
I49.2 Junctional premature depolarisation	0.011	0.989	0.000
M22.1 Recurrent subluxation of patella	0.011	0.989	0.000
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.011	0.989	0.000
M21.22 Flexion deformity (Upper arm)	0.011	0.989	0.000
M20.0 Deformity of finger(s)	0.011	0.989	0.000
Z85.4 Personal history of malignant neoplasm of genital organs	0.011	0.989	0.000
M21.20 Flexion deformity (Multiple sites)	0.011	0.989	0.000
M25.58 Pain in joint (Other)	0.011	0.989	0.000
M21.29 Flexion deformity (Site unspecified)	0.011	0.989	0.000
M21.28 Flexion deformity (Other)	0.011	0.989	0.000
M21.21 Flexion deformity (Shoulder region)	0.011	0.989	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.011	0.989	0.000
M21.8 Other specified acquired deformities of limbs	0.011	0.989	0.000
M33.9 Dermatopolymyositis, unspecified	0.011	0.989	0.000
I37 Pulmonary valve disorders	0.011	0.989	0.000
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.011	0.989	0.000
M31 Other necrotising vasculopathies	0.011	0.989	0.000
M25.81 Other specified joint disorders (Shoulder region)	0.011	0.989	0.000
M25.89 Other specified joint disorders (Site unspecified)	0.011	0.989	0.000
M25.80 Other specified joint disorders (Multiple sites)	0.011	0.989	0.000
M22.8 Other disorders of patella	0.011	0.989	0.000
M30 Polyarteritis nodosa and related conditions	0.011	0.989	0.000
M21.27 Flexion deformity (Ankle and foot)	0.011	0.989	0.000
M33.0 Juvenile dermatomyositis	0.011	0.989	0.000
R23.2 Flushing	0.000	0.989	0.011
M21.23 Flexion deformity (Forearm)	0.010	0.989	0.000
M25.09 Haemarthrosis (Site unspecified)	0.010	0.989	0.000
M25.08 Haemarthrosis (Other)	0.010	0.989	0.000
M25.07 Haemarthrosis (Ankle and foot)	0.010	0.989	0.000
M25.05 Haemarthrosis (Pelvic region and thigh)	0.010	0.989	0.000
M25.04 Haemarthrosis (Hand)	0.010	0.989	0.000
M25.03 Haemarthrosis (Forearm)	0.010	0.989	0.000
M25.02 Haemarthrosis (Upper arm)	0.010	0.989	0.000
M25.01 Haemarthrosis (Shoulder region)	0.010	0.989	0.000
M25.00 Haemarthrosis (Multiple sites)	0.010	0.989	0.000
M21.94 Acquired deformity of limb, unspecified (Hand)	0.010	0.989	0.000
I42.0 Dilated cardiomyopathy	0.011	0.989	0.000
M25.51 Pain in joint (Shoulder region)	0.011	0.989	0.000
M25.74 Osteophyte (Hand)	0.011	0.989	0.000
M25.97 Joint disorder, unspecified (Ankle and foot)	0.010	0.989	0.000
M25.91 Joint disorder, unspecified (Shoulder region)	0.010	0.989	0.000
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.010	0.989	0.000
M35.7 Hypermobility syndrome	0.010	0.989	0.000
I49.0 Ventricular fibrillation and flutter	0.010	0.990	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.010	0.990	0.000
I49.4 Other and unspecified premature depolarisation	0.010	0.990	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.010	0.990	0.000
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.010	0.990	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.010	0.990	0.000
M25.88 Other specified joint disorders (Other)	0.010	0.990	0.000
M25.99 Joint disorder, unspecified (Site unspecified)	0.010	0.990	0.000
M25.52 Pain in joint (Upper arm)	0.010	0.990	0.000
M33.1 Other dermatomyositis	0.010	0.990	0.000
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.010	0.990	0.000
M21.18 Varus deformity, not elsewhere classified (Other)	0.010	0.990	0.000
M21.14 Varus deformity, not elsewhere classified (Hand)	0.010	0.990	0.000
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.010	0.990	0.000
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.010	0.990	0.000
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.010	0.990	0.000
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.010	0.990	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.010	0.990	0.000
M24.0 Loose body in joint	0.010	0.990	0.000
M23 Internal derangement of knee	0.010	0.990	0.000
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.010	0.990	0.000
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.010	0.990	0.000
M21.73 Unequal limb length (acquired) (Forearm)	0.010	0.990	0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.010	0.990	0.000
I37.1 Pulmonary valve insufficiency	0.010	0.990	0.000
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.010	0.990	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.010	0.990	0.000
M21.79 Unequal limb length (acquired) (Site unspecified)	0.010	0.990	0.000
M21.78 Unequal limb length (acquired)-Other	0.010	0.990	0.000
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.010	0.990	0.000
M21.74 Unequal limb length (acquired) (Hand)	0.010	0.990	0.000
M21.72 Unequal limb length (acquired) (Upper arm)	0.010	0.990	0.000
M21.71 Unequal limb length (acquired)-Shldr region	0.010	0.990	0.000
M21.70 Unequal limb length (acquired) (Multiple sites)	0.010	0.990	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.010	0.990	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.010	0.990	0.000
R23.0 Cyanosis	0.000	0.990	0.010
M25.82 Other specified joint disorders (Upper arm)	0.010	0.990	0.000
M21.76 Unequal limb length (acquired) (Lower leg)	0.010	0.990	0.000
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.010	0.990	0.000
M21.98 Acquired deformity of limb, unspecified-Other	0.010	0.990	0.000
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.010	0.990	0.000
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.010	0.990	0.000
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.010	0.990	0.000
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.010	0.990	0.000
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.010	0.990	0.000
M24.6 Ankylosis of joint	0.010	0.990	0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.010	0.990	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.010	0.990	0.000
I42 Cardiomyopathy	0.010	0.990	0.000
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.010	0.990	0.000
M25.92 Joint disorder, unspecified (Upper arm)	0.010	0.990	0.000
M20.4 Other hammer toe(s) (acquired)	0.010	0.990	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.010	0.990	0.000
M25.98 Joint disorder, unspecified (Other)	0.010	0.990	0.000
M25.93 Joint disorder, unspecified (Forearm)	0.010	0.990	0.000
M25.90 Joint disorder, unspecified (Multiple sites)	0.010	0.990	0.000
M23.4 Loose body in knee	0.010	0.990	0.000
M24.9 Joint derangement, unspecified	0.010	0.990	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.009	0.990	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.009	0.990	0.000
M35.5 Multifocal fibrosclerosis	0.009	0.990	0.000
S80.9 Superficial injury of lower leg, unspecified	0.010	0.990	0.000
I49.9 Cardiac arrhythmia, unspecified	0.010	0.990	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.009	0.990	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.009	0.990	0.000
M21.0 Valgus deformity, not elsewhere classified	0.009	0.990	0.000
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.009	0.991	0.000
M21.68 Other acquired deformities of ankle and foot-Other	0.009	0.991	0.000
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.009	0.991	0.000
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.009	0.991	0.000
M21.64 Other acquired deformities of ankle and foot-Hand	0.009	0.991	0.000
M21.63 Other acquired deformities of ankle and foot-Forearm	0.009	0.991	0.000
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.009	0.991	0.000
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.009	0.991	0.000
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.009	0.991	0.000
M24.02 Loose body in joint (Upper arm)	0.009	0.991	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.009	0.991	0.000
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.009	0.991	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.009	0.991	0.000
M25.34 Other instability of joint (Hand)	0.009	0.991	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.009	0.991	0.000
M21.39 Wrist or foot drop (acquired)-Site unspec	0.009	0.991	0.000
M21.38 Wrist or foot drop (acquired)-Other	0.009	0.991	0.000
M21.36 Wrist or foot drop (acquired)-Lower leg	0.009	0.991	0.000
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.009	0.991	0.000
M21.34 Wrist or foot drop (acquired) (Hand)	0.009	0.991	0.000
M21.32 Wrist or foot drop (acquired)-Upper arm	0.009	0.991	0.000
M21.31 Wrist or foot drop (acquired)-Shldr region	0.009	0.991	0.000
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.009	0.991	0.000
M25.84 Other specified joint disorders (Hand)	0.009	0.991	0.000
M21.33 Wrist or foot drop (acquired) (Forearm)	0.009	0.991	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.009	0.991	0.000
M25.59 Pain in joint (Site unspecified)	0.009	0.991	0.000
M21.49 Flat foot [pes planus] (acquired)-Site unspec	0.009	0.991	0.000
M21.48 Flat foot [pes planus] (acquired)-Other	0.009	0.991	0.000
M21.46 Flat foot [pes planus] (acquired)-Lower leg	0.009	0.991	0.000
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh	0.009	0.991	0.000
M21.44 Flat foot [pes planus] (acquired)-Hand	0.009	0.991	0.000
M21.43 Flat foot [pes planus] (acquired)-Forearm	0.009	0.991	0.000
M21.42 Flat foot [pes planus] (acquired)-Upper arm	0.009	0.991	0.000
M21.41 Flat foot [pes planus] (acquired)-Shldr region	0.009	0.991	0.000
M21.40 Flat foot [pes planus] (acquired)-Mult sites	0.009	0.991	0.000
M25.56 Pain in joint (Lower leg)	0.009	0.991	0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.009	0.991	0.000
M36.3 Arthropathy in other blood disorders	0.009	0.991	0.000
M36.2 Haemophilic arthropathy	0.009	0.991	0.000
M36.1 Arthropathy in neoplastic disease	0.009	0.991	0.000
M36.0 Dermato(poly)myositis in neoplastic disease	0.009	0.991	0.000
M25.36 Other instability of joint (Lower leg)	0.009	0.991	0.000
M24.5 Contracture of joint	0.009	0.991	0.000
M35.8 Other specified systemic involvement of connective tissue	0.009	0.991	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.009	0.991	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.009	0.991	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.009	0.991	0.000
M32.1 Systemic lupus erythematosus with organ or system involvement	0.009	0.991	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.009	0.991	0.000
M23.49 Loose body in knee-Unspec lig/men	0.009	0.991	0.000
M25.33 Other instability of joint (Forearm)	0.009	0.991	0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.009	0.991	0.000
I45 Other conduction disorders	0.009	0.991	0.000
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.009	0.991	0.000
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.009	0.991	0.000
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.009	0.991	0.000
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.009	0.991	0.000
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.009	0.991	0.000
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.009	0.991	0.000
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.009	0.991	0.000
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.009	0.991	0.000
M24.7 Protrusio acetabuli	0.009	0.991	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.009	0.991	0.000
M23.8 Other internal derangements of knee	0.009	0.991	0.000
M35.0 Sicca syndrome [Sjogren]	0.009	0.991	0.000
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.009	0.991	0.000
M35.1 Other overlap syndromes	0.009	0.991	0.000
M25.19 Fistula of joint (Site unspecified)	0.009	0.991	0.000
M25.18 Fistula of joint (Other)	0.009	0.991	0.000
M25.17 Fistula of joint (Ankle and foot)	0.009	0.991	0.000
M25.16 Fistula of joint (Lower leg)	0.009	0.991	0.000
M25.15 Fistula of joint (Pelvic region and thigh)	0.009	0.991	0.000
M25.14 Fistula of joint (Hand)	0.009	0.991	0.000
M25.13 Fistula of joint (Forearm)	0.009	0.991	0.000
M25.12 Fistula of joint (Upper arm)	0.009	0.991	0.000
M25.11 Fistula of joint (Shoulder region)	0.009	0.991	0.000
M25.10 Fistula of joint (Multiple sites)	0.009	0.991	0.000
M25.29 Flail joint (Site unspecified)	0.009	0.991	0.000
M25.28 Flail joint (Other)	0.009	0.991	0.000
M25.27 Flail joint (Ankle and foot)	0.009	0.991	0.000
M25.26 Flail joint (Lower leg)	0.009	0.991	0.000
M25.25 Flail joint (Pelvic region and thigh)	0.009	0.991	0.000
M25.24 Flail joint (Hand)	0.009	0.991	0.000
M25.23 Flail joint (Forearm)	0.009	0.991	0.000
M25.22 Flail joint (Upper arm)	0.009	0.991	0.000
M25.21 Flail joint (Shoulder region)	0.009	0.991	0.000
M25.20 Flail joint (Multiple sites)	0.009	0.991	0.000
M32.8 Other forms of systemic lupus erythematosus	0.009	0.991	0.000
M25.4 Effusion of joint	0.009	0.991	0.000
I40 Acute myocarditis	0.009	0.991	0.000
I30 Acute pericarditis	0.009	0.991	0.000
M25.72 Osteophyte (Upper arm)	0.009	0.991	0.000
M31.9 Necrotising vasculopathy, unspecified	0.009	0.991	0.000
M23.5 Chronic instability of knee	0.009	0.991	0.000
M25.39 Other instability of joint (Site unspecified)	0.009	0.991	0.000
M25.38 Other instability of joint (Other)	0.009	0.991	0.000
M25.35 Other instability of joint (Pelvic region and thigh)	0.009	0.991	0.000
M25.32 Other instability of joint (Upper arm)	0.009	0.991	0.000
M25.30 Other instability of joint (Multiple sites)	0.009	0.991	0.000
I52 Other heart disorders in diseases classified elsewhere	0.009	0.991	0.000
I48 Atrial fibrillation and flutter	0.009	0.991	0.000
I41 Myocarditis in diseases classified elsewhere	0.009	0.991	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.009	0.991	0.000
I32 Pericarditis in diseases classified elsewhere	0.009	0.991	0.000
I51.9 Heart disease, unspecified	0.009	0.991	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.009	0.991	0.000
M25.31 Other instability of joint (Shoulder region)	0.008	0.991	0.000
R23.1 Pallor	0.000	0.991	0.009
M21.83 Other specified acquired deformities of limbs (Forearm)	0.008	0.991	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.008	0.991	0.000
I45.5 Other specified heart block	0.009	0.991	0.000
M25.54 Pain in joint (Hand)	0.008	0.991	0.000
M25.73 Osteophyte (Forearm)	0.008	0.991	0.000
I37.0 Pulmonary valve stenosis	0.008	0.992	0.000
M25.78 Osteophyte (Other)	0.008	0.992	0.000
M25.70 Osteophyte (Multiple sites)	0.008	0.992	0.000
M31.3 Wegener's granulomatosis	0.008	0.992	0.000
I36 Nonrheumatic tricuspid valve disorders	0.008	0.992	0.000
M22.10 Recurrent subluxation of patella, unspecified knee	0.008	0.992	0.000
I38 Endocarditis, valve unspecified	0.008	0.992	0.000
R23.8 Other and unspecified skin changes	0.000	0.992	0.008
M24.2 Disorder of ligament	0.008	0.992	0.000
M23.80 Other internal derangements of knee (Multiple sites)	0.008	0.992	0.000
S32.40 Fracture of acetabulum (closed)	0.000	0.992	0.008
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.008	0.992	0.000
M31.7 Microscopic polyangiitis	0.008	0.992	0.000
M31.1 Thrombotic microangiopathy	0.008	0.992	0.000
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.008	0.992	0.000
M21.88 Other specified acquired deformities of limbs-Other	0.008	0.992	0.000
M21.84 Other specified acquired deformities of limbs (Hand)	0.008	0.992	0.000
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.008	0.992	0.000
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.008	0.992	0.000
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.008	0.992	0.000
I37.9 Pulmonary valve disorder, unspecified	0.008	0.992	0.000
I37.8 Other pulmonary valve disorders	0.008	0.992	0.000
I37.2 Pulmonary valve stenosis with insufficiency	0.008	0.992	0.000
M31.2 Lethal midline granuloma	0.008	0.992	0.000
M24.66 Ankylosis of joint (Lower leg)	0.008	0.992	0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.008	0.992	0.000
M30.2 Juvenile polyarteritis	0.008	0.992	0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.008	0.992	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.008	0.992	0.000
M24.64 Ankylosis of joint (Hand)	0.008	0.992	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.008	0.992	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.008	0.992	0.000
M25.94 Joint disorder, unspecified (Hand)	0.008	0.992	0.000
I47 Paroxysmal tachycardia	0.008	0.992	0.000
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.007	0.992	0.000
M31.8 Other specified necrotising vasculopathies	0.008	0.992	0.000
M23.9 Internal derangement of knee, unspecified	0.008	0.992	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.008	0.992	0.000
M35.2 Behcet's disease	0.007	0.992	0.000
I31 Other diseases of pericardium	0.008	0.992	0.000
M24.04 Loose body in joint (Hand)	0.007	0.992	0.000
M24.07 Loose body in joint (Ankle and foot)	0.008	0.992	0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.008	0.992	0.000
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.007	0.992	0.000
M24.1 Other articular cartilage disorders	0.007	0.992	0.000
M24.09 Loose body in joint (Site unspecified)	0.007	0.992	0.000
M24.08 Loose body in joint (Other)	0.007	0.992	0.000
M24.00 Loose body in joint (Multiple sites)	0.007	0.992	0.000
M23.42 Loose body in knee-Pst lig/hrn men	0.007	0.992	0.000
M23.40 Loose body in knee-Mult sites	0.007	0.992	0.000
M24.57 Contracture of joint (Ankle and foot)	0.007	0.992	0.000
M24.94 Joint derangement, unspecified (Hand)	0.007	0.992	0.000
M25.76 Osteophyte (Lower leg)	0.008	0.992	0.000
M24.05 Loose body in joint (Pelvic region and thigh)	0.007	0.992	0.000
I42.2 Other hypertrophic cardiomyopathy	0.007	0.993	0.000
I42.6 Alcoholic cardiomyopathy	0.007	0.993	0.000
M31.0 Hypersensitivity angiitis	0.007	0.993	0.000
M23.44 Loose body in knee-Lat lig/ant men	0.007	0.993	0.000
M23.43 Loose body in knee-Med lig/oth men	0.007	0.993	0.000
M24.03 Loose body in joint (Forearm)	0.007	0.993	0.000
M25.40 Effusion of joint (Multiple sites)	0.007	0.993	0.000
I45.6 Preexcitation syndrome	0.007	0.993	0.000
S32.4 Fracture of acetabulum	0.000	0.993	0.007
M30.0 Polyarteritis nodosa	0.007	0.993	0.000
I71 Aortic aneurysm and dissection	0.007	0.993	0.000
M24.69 Ankylosis of joint (Site unspecified)	0.007	0.993	0.000
M24.68 Ankylosis of joint (Other)	0.007	0.993	0.000
M24.63 Ankylosis of joint (Forearm)	0.007	0.993	0.000
M24.62 Ankylosis of joint (Upper arm)	0.007	0.993	0.000
M24.61 Ankylosis of joint (Shoulder region)	0.007	0.993	0.000
M24.60 Ankylosis of joint (Multiple sites)	0.007	0.993	0.000
I43.1 Cardiomyopathy in metabolic diseases	0.007	0.993	0.000
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.007	0.993	0.000
M24.56 Contracture of joint (Lower leg)	0.007	0.993	0.000
I42.3 Endomyocardial (eosinophilic) disease	0.007	0.993	0.000
I72.4 Aneurysm of artery of lower extremity	0.007	0.993	0.000
I45.9 Conduction disorder, unspecified	0.007	0.993	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.007	0.993	0.000
M25.96 Joint disorder, unspecified (Lower leg)	0.007	0.993	0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)	0.007	0.993	0.000
I42.7 Cardiomyopathy due to drugs and other external agents	0.007	0.993	0.000
I42.4 Endocardial fibroelastosis	0.007	0.993	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.007	0.993	0.000
M23.47 Loose body in knee-Capsular lig	0.007	0.993	0.000
M23.45 Loose body in knee-Pst hrn lat men	0.007	0.993	0.000
M24.99 Joint derangement, unspecified (Site unspecified)	0.007	0.993	0.000
M24.98 Joint derangement, unspecified (Other)	0.007	0.993	0.000
M24.97 Joint derangement, unspecified (Ankle and foot)	0.007	0.993	0.000
M24.95 Joint derangement, unspecified (Pelvic region and thigh)	0.007	0.993	0.000
M24.93 Joint derangement, unspecified (Forearm)	0.007	0.993	0.000
M24.92 Joint derangement, unspecified (Upper arm)	0.007	0.993	0.000
M24.90 Joint derangement, unspecified (Multiple sites)	0.007	0.993	0.000
M25.77 Osteophyte (Ankle and foot)	0.007	0.993	0.000
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified	0.007	0.993	0.000
M25.79 Osteophyte (Site unspecified)	0.007	0.993	0.000
I40.9 Acute myocarditis, unspecified	0.007	0.993	0.000
I47.9 Paroxysmal tachycardia, unspecified	0.007	0.993	0.000
I30.1 Infective pericarditis	0.007	0.993	0.000
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.007	0.993	0.000
M21.08 Valgus deformity, not elsewhere classified (Other)	0.007	0.993	0.000
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.007	0.993	0.000
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.007	0.993	0.000
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.007	0.993	0.000
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.007	0.993	0.000
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.007	0.993	0.000
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.007	0.993	0.000
M23.46 Loose body in knee-O/unsp lat men	0.007	0.993	0.000
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.007	0.993	0.000
M24.96 Joint derangement, unspecified (Lower leg)	0.007	0.993	0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.007	0.993	0.000
M22.2 Patellofemoral disorders	0.007	0.993	0.000
M24.39 Pathological dislocation and subluxation of joint, not elsewhere classified (Site unspecified)	0.007	0.993	0.000
M24.38 Pathological dislocation and subluxation of joint, not elsewhere classified (Other)	0.007	0.993	0.000
M24.36 Pathological dislocation and subluxation of joint, not elsewhere classified (Lower leg)	0.007	0.993	0.000
M24.35 Pathological dislocation and subluxation of joint, not elsewhere classified (Pelvic region and thigh)	0.007	0.993	0.000
M24.34 Pathological dislocation and subluxation of joint, not elsewhere classified (Hand)	0.007	0.993	0.000
M24.33 Pathological dislocation and subluxation of joint, not elsewhere classified (Forearm)	0.007	0.993	0.000
M24.32 Pathological dislocation and subluxation of joint, not elsewhere classified (Upper arm)	0.007	0.993	0.000
M24.31 Pathological dislocation and subluxation of joint, not elsewhere classified (Shoulder region)	0.007	0.993	0.000
M24.30 Pathological dislocation and subluxation of joint, not elsewhere classified (Multiple sites)	0.007	0.993	0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.007	0.993	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.007	0.993	0.000
I34 Nonrheumatic mitral valve disorders	0.007	0.993	0.000
I43.0 Cardiomyopathy in infectious and parasitic diseases classified elsewhere	0.007	0.993	0.000
M24.06 Loose body in joint-Lower leg	0.007	0.993	0.000
M24.91 Joint derangement, unspecified (Shoulder region)	0.007	0.993	0.000
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.007	0.993	0.000
I31.9 Disease of pericardium, unspecified	0.007	0.993	0.000
M24.17 Other articular cartilage disorders (Ankle and foot)	0.007	0.993	0.000
M24.59 Contracture of joint (Site unspecified)	0.007	0.993	0.000
M24.58 Contracture of joint (Other)	0.007	0.993	0.000
M24.53 Contracture of joint (Forearm)	0.007	0.993	0.000
M24.50 Contracture of joint (Multiple sites)	0.007	0.993	0.000
M32.90 Systemic lupus erythematosus, unspecified, Multiple sites	0.007	0.993	0.000
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.007	0.993	0.000
M24.79 Protrusio acetabuli-Site unspec	0.007	0.993	0.000
M24.78 Protrusio acetabuli-Other	0.007	0.993	0.000
M24.77 Protrusio acetabuli-Ankle/foot	0.007	0.993	0.000
M24.76 Protrusio acetabuli-Lower leg	0.007	0.993	0.000
M24.74 Protrusio acetabuli-Hand	0.007	0.993	0.000
M24.73 Protrusio acetabuli-Forearm	0.007	0.993	0.000
M24.72 Protrusio acetabuli-Upper arm	0.007	0.993	0.000
M24.71 Protrusio acetabuli-Shldr region	0.007	0.993	0.000
M24.70 Protrusio acetabuli-Mult sites	0.007	0.993	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.006	0.993	0.000
I43.2 Cardiomyopathy in nutritional diseases	0.007	0.993	0.000
M25.43 Effusion of joint (Forearm)	0.007	0.993	0.000
S32 Fracture of lumbar spine and pelvis	0.000	0.993	0.007
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.007	0.993	0.000
M24.37 Pathological dislocation and subluxation of joint, not elsewhere classified (Ankle and foot)	0.007	0.993	0.000
I45.0 Right fascicular block	0.007	0.993	0.000
M23.41 Loose body in knee-Ant lig/hrn men	0.007	0.993	0.000
I42.1 Obstructive hypertrophic cardiomyopathy	0.007	0.993	0.000
M24.55 Contracture of joint (Pelvic region and thigh)	0.007	0.993	0.000
M23.1 Discoid meniscus (congenital)	0.007	0.993	0.000
M23.50 Chronic instability of knee (Multiple sites)	0.007	0.993	0.000
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.006	0.993	0.000
M24.51 Contracture of joint (Shoulder region)	0.006	0.993	0.000
M25.49 Effusion of joint (Site unspecified)	0.006	0.993	0.000
M25.48 Effusion of joint (Other)	0.006	0.993	0.000
I43.8 Cardiomyopathy in other diseases classified elsewhere	0.006	0.993	0.000
I30.0 Acute nonspecific idiopathic pericarditis	0.006	0.993	0.000
I40.8 Other acute myocarditis	0.006	0.993	0.000
I40.1 Isolated myocarditis	0.006	0.993	0.000
I42.5 Other restrictive cardiomyopathy	0.006	0.993	0.000
M25.42 Effusion of joint (Upper arm)	0.006	0.993	0.000
M25.44 Effusion of joint (Hand)	0.006	0.993	0.000
M23.57 Chronic instability of knee (Capsular ligament)	0.006	0.993	0.000
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.006	0.993	0.000
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.006	0.993	0.000
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.006	0.993	0.000
I32.8 Pericarditis in other diseases classified elsewhere	0.006	0.993	0.000
I32.1 Pericarditis in other infectious and parasitic diseases classified elsewhere	0.006	0.993	0.000
I32.0 Pericarditis in bacterial diseases classified elsewhere	0.006	0.993	0.000
I39.8 Endocarditis, valve unspecified, in diseases classified elsewhere	0.006	0.993	0.000
I39.4 Multiple valve disorders in diseases classified elsewhere	0.006	0.993	0.000
I39.3 Pulmonary valve disorders in diseases classified elsewhere	0.006	0.993	0.000
I39.2 Tricuspid valve disorders in diseases classified elsewhere	0.006	0.993	0.000
I39.1 Aortic valve disorders in diseases classified elsewhere	0.006	0.993	0.000
I39.0 Mitral valve disorders in diseases classified elsewhere	0.006	0.993	0.000
I41.8 Myocarditis in other diseases classified elsewhere	0.006	0.993	0.000
I41.2 Myocarditis in other infectious and parasitic diseases classified elsewhere	0.006	0.993	0.000
I41.1 Myocarditis in viral diseases classified elsewhere	0.006	0.993	0.000
I41.0 Myocarditis in bacterial diseases classified elsewhere	0.006	0.993	0.000
I48.9 Atrial fibrillation and atrial flutter, unspecified	0.006	0.993	0.000
I48.4 Atypical atrial flutter	0.006	0.993	0.000
I48.3 Typical atrial flutter	0.006	0.993	0.000
I48.2 Chronic atrial fibrillation	0.006	0.993	0.000
I48.1 Persistent atrial fibrillation	0.006	0.993	0.000
I48.0 Paroxysmal atrial fibrillation	0.006	0.993	0.000
I52.8 Other heart disorders in other diseases classified elsewhere	0.006	0.993	0.000
I52.1 Other heart disorders in other infectious and parasitic diseases classified elsewhere	0.006	0.993	0.000
I52.0 Other heart disorders in bacterial diseases classified elsewhere	0.006	0.993	0.000
I45.8 Other specified conduction disorders	0.006	0.993	0.000
I45.4 Nonspecific intraventricular block	0.006	0.993	0.000
I45.2 Bifascicular block	0.006	0.993	0.000
M24.49 Recurrent dislocation and subluxation of joint (Site unspecified)	0.006	0.993	0.000
M24.48 Recurrent dislocation and subluxation of joint (Other)	0.006	0.993	0.000
M24.46 Recurrent dislocation and subluxation of joint (Lower leg)	0.006	0.993	0.000
M24.42 Recurrent dislocation and subluxation of joint (Upper arm)	0.006	0.993	0.000
M24.40 Recurrent dislocation and subluxation of joint (Multiple sites)	0.006	0.993	0.000
I33 Acute and subacute endocarditis	0.006	0.993	0.000
M25.41 Effusion of joint (Shoulder region)	0.006	0.994	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations