TreeWAS – Variant ID: rs2110001

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I35.0 Aortic (valve) stenosis	0.000	0.902	0.098
I35.2 Aortic (valve) stenosis with insufficiency	0.000	0.907	0.093
I35 Nonrheumatic aortic valve disorders	0.000	0.910	0.090
G56.0 Carpal tunnel syndrome	0.000	0.926	0.074
I35.9 Aortic valve disorder, unspecified	0.000	0.926	0.074
I35.8 Other aortic valve disorders	0.000	0.932	0.068
R00.8 Other and unspecified abnormalities of heart beat	0.000	0.946	0.054
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.000	0.963	0.037
Z96.6 Presence of orthopaedic joint implants	0.000	0.966	0.034
K70.3 Alcoholic cirrhosis of liver	0.034	0.966	0.000
I35.1 Aortic (valve) insufficiency	0.000	0.969	0.031
K70 Alcoholic liver disease	0.027	0.973	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.000	0.977	0.023
K70.4 Alcoholic hepatic failure	0.023	0.977	0.000
K70.1 Alcoholic hepatitis	0.023	0.977	0.000
K70.0 Alcoholic fatty liver	0.021	0.979	0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.000	0.979	0.021
K76.6 Portal hypertension	0.020	0.980	0.000
K70.2 Alcoholic fibrosis and sclerosis of liver	0.019	0.981	0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.000	0.981	0.019
K70-K77 Diseases of liver	0.018	0.982	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.000	0.983	0.017
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.000	0.983	0.017
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.000	0.983	0.017
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.000	0.983	0.017
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.000	0.983	0.017
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.000	0.983	0.017
K74.6 Other and unspecified cirrhosis of liver	0.017	0.983	0.000
K76 Other diseases of liver	0.016	0.984	0.000
K74 Fibrosis and cirrhosis of liver	0.016	0.984	0.000
K72 Hepatic failure, not elsewhere classified	0.015	0.984	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.986	0.014
K71 Toxic liver disease	0.014	0.986	0.000
G56 Mononeuropathies of upper limb	0.000	0.986	0.014
K74.0 Hepatic fibrosis	0.013	0.987	0.000
K72.0 Acute and subacute hepatic failure	0.013	0.987	0.000
K77 Liver disorders in diseases classified elsewhere	0.013	0.987	0.000
K70.9 Alcoholic liver disease, unspecified	0.012	0.988	0.000
Z73.3 Stress, not elsewhere classified	0.012	0.988	0.000
K72.9 Hepatic failure, unspecified	0.012	0.988	0.000
K76.5 Hepatic veno-occlusive disease	0.012	0.988	0.000
K76.4 Peliosis hepatis	0.012	0.988	0.000
K76.3 Infarction of liver	0.012	0.988	0.000
K76.2 Central haemorrhagic necrosis of liver	0.012	0.988	0.000
K74.4 Secondary biliary cirrhosis	0.012	0.988	0.000
K74.2 Hepatic fibrosis with hepatic sclerosis	0.012	0.988	0.000
K74.1 Hepatic sclerosis	0.012	0.988	0.000
K76.9 Liver disease, unspecified	0.012	0.988	0.000
K72.1 Chronic hepatic failure	0.011	0.989	0.000
K76.1 Chronic passive congestion of liver	0.011	0.989	0.000
Z73.9 Problem related to life-management difficulty, unspecified	0.011	0.989	0.000
K73 Chronic hepatitis, not elsewhere classified	0.011	0.989	0.000
G56.4 Causalgia	0.000	0.989	0.011
K71.1 Toxic liver disease with hepatic necrosis	0.010	0.989	0.000
K76.7 Hepatorenal syndrome	0.010	0.989	0.000
K71.9 Toxic liver disease, unspecified	0.010	0.990	0.000
K71.8 Toxic liver disease with other disorders of liver	0.010	0.990	0.000
K71.7 Toxic liver disease with fibrosis and cirrhosis of liver	0.010	0.990	0.000
K71.6 Toxic liver disease with hepatitis, not elsewhere classified	0.010	0.990	0.000
K71.5 Toxic liver disease with chronic active hepatitis	0.010	0.990	0.000
K71.4 Toxic liver disease with chronic lobular hepatitis	0.010	0.990	0.000
K71.3 Toxic liver disease with chronic persistent hepatitis	0.010	0.990	0.000
K71.2 Toxic liver disease with acute hepatitis	0.010	0.990	0.000
K71.0 Toxic liver disease with cholestasis	0.010	0.990	0.000
G56.8 Other mononeuropathies of upper limb	0.000	0.990	0.010
Z73 Problems related to life-management difficulty	0.010	0.990	0.000
G56.1 Other lesions of median nerve	0.000	0.990	0.010
K77.8 Liver disorders in other diseases classified elsewhere	0.009	0.990	0.000
K77.0 Liver disorders in infectious and parasitic diseases classified elsewhere	0.009	0.990	0.000
G56.9 Mononeuropathy of upper limb, unspecified	0.000	0.990	0.010
K74.5 Biliary cirrhosis, unspecified	0.009	0.991	0.000
K35.0 Acute appendicitis with generalised peritonitis	0.009	0.991	0.000
G56.3 Lesion of radial nerve	0.000	0.991	0.009
N13.8 Other obstructive and reflux uropathy	0.000	0.992	0.008
K73.1 Chronic lobular hepatitis, not elsewhere classified	0.008	0.992	0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified	0.008	0.992	0.000
R10.2 Pelvic and perineal pain	0.000	0.992	0.008
K83.8 Other specified diseases of biliary tract	0.000	0.992	0.008
K73.8 Other chronic hepatitis, not elsewhere classified	0.007	0.992	0.000
K73.2 Chronic active hepatitis, not elsewhere classified	0.007	0.993	0.000
Z73.5 Social role conflict, not elsewhere classified	0.007	0.993	0.000
Z73.4 Inadequate social skills, not elsewhere classified	0.007	0.993	0.000
Z73.2 Lack of relaxation and leisure	0.007	0.993	0.000
Z73.1 Accentuation of personality traits	0.007	0.993	0.000
Z73.0 Burn-out	0.007	0.993	0.000
Z73.6 Limitation of activities due to disability	0.007	0.993	0.000
N13.5 Kinking and stricture of ureter without hydronephrosis	0.000	0.993	0.007
K73.9 Chronic hepatitis, unspecified	0.007	0.993	0.000
N31.8 Other neuromuscular dysfunction of bladder	0.007	0.993	0.000
K76.0 Fatty (change of) liver, not elsewhere classified	0.007	0.993	0.000
E27.1 Primary adrenocortical insufficiency	0.000	0.993	0.007
H43.8 Other disorders of vitreous body	0.006	0.994	0.000
I45.9 Conduction disorder, unspecified	0.000	0.994	0.006
O16 Unspecified maternal hypertension	0.006	0.994	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.994	0.006
N13.0 Hydronephrosis with ureteropelvic junction obstruction	0.000	0.994	0.006
Z73.8 Other problems related to life-management difficulty	0.005	0.995	0.000
N13 Obstructive and reflux uropathy	0.000	0.995	0.005
E27 Other disorders of adrenal gland	0.000	0.995	0.005
K76.8 Other specified diseases of liver	0.005	0.995	0.000
R00 Abnormalities of heart beat	0.000	0.995	0.005
I84.3 External thrombosed haemorrhoids	0.004	0.996	0.000
K74.3 Primary biliary cirrhosis	0.004	0.996	0.000
N13.3 Other and unspecified hydronephrosis	0.000	0.996	0.004
K75 Other inflammatory liver diseases	0.004	0.996	0.000
E27.9 Disorder of adrenal gland, unspecified	0.000	0.996	0.004
K62.9 Disease of anus and rectum, unspecified	0.004	0.996	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.996	0.004
E27.2 Addisonian crisis	0.000	0.996	0.004
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.000	0.996	0.004
H43 Disorders of vitreous body	0.004	0.996	0.000
E27.8 Other specified disorders of adrenal gland	0.000	0.996	0.004
H43.9 Disorder of vitreous body, unspecified	0.004	0.996	0.000
E27.5 Adrenomedullary hyperfunction	0.000	0.996	0.004
E27.0 Other adrenocortical overactivity	0.000	0.996	0.004
N13.7 Vesicoureteral-reflux-associated uropathy	0.000	0.996	0.004
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.996	0.004
R73.0 Abnormal glucose tolerance test	0.004	0.996	0.000
G93.8 Other specified disorders of brain	0.000	0.996	0.004
M80 Osteoporosis with pathological fracture	0.000	0.996	0.003
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.004	0.996	0.000
R00.0 Tachycardia, unspecified	0.000	0.996	0.004
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.004	0.996	0.000
S32.50 Fracture of pubis (closed)	0.000	0.996	0.004
N13.4 Hydroureter	0.000	0.997	0.003
H43.2 Crystalline deposits in vitreous body	0.003	0.997	0.000
K75.2 Nonspecific reactive hepatitis	0.003	0.997	0.000
K75.1 Phlebitis of portal vein	0.003	0.997	0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.003	0.997	0.000
K75.8 Other specified inflammatory liver diseases	0.003	0.997	0.000
Y40.8 Other systemic antibiotics	0.000	0.997	0.003
H43.3 Other vitreous opacities	0.003	0.997	0.000
H11.4 Other conjunctival vascular disorders and cysts	0.003	0.997	0.000
H43.0 Vitreous prolapse	0.003	0.997	0.000
K83 Other diseases of biliary tract	0.000	0.997	0.003
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.003	0.997	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.003	0.997	0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.000	0.997	0.003
Y48.4 Anaesthetic, unspecified	0.000	0.997	0.003
U80.1 Methicillin resistant agent	0.003	0.997	0.000
K75.3 Granulomatous hepatitis, not elsewhere classified	0.003	0.997	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.000	0.997	0.003
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.000	0.997	0.003
M80.2 Osteoporosis of disuse with pathological fracture	0.000	0.997	0.003
Y48.2 Other and unspecified general anaesthetics	0.000	0.997	0.003
Z04.8 Examination and observation for other specified reasons	0.003	0.997	0.000
Y48 Anaesthetics and therapeutic gases	0.000	0.997	0.003
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.000	0.997	0.003
O15 Eclampsia	0.003	0.997	0.000
K75.9 Inflammatory liver disease, unspecified	0.003	0.997	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.000	0.997	0.003
N13.6 Pyonephrosis	0.000	0.997	0.002
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.000	0.997	0.003
K83.3 Fistula of bile duct	0.000	0.997	0.003
K83.9 Disease of biliary tract, unspecified	0.000	0.997	0.003
G56.2 Lesion of ulnar nerve	0.000	0.997	0.003
O10.0 Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium	0.003	0.997	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.000	0.997	0.003
Y52 Agents primarily affecting the cardiovascular system	0.000	0.997	0.003
Z96 Presence of other functional implants	0.000	0.997	0.003
K83.0 Cholangitis	0.000	0.997	0.003
Z96.9 Presence of functional implant, unspecified	0.000	0.997	0.002
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.002	0.997	0.000
H90.5 Sensorineural hearing loss, unspecified	0.002	0.997	0.000
K83.2 Perforation of bile duct	0.000	0.997	0.002
M80.8 Other osteoporosis with pathological fracture	0.000	0.997	0.002
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.000	0.997	0.002
M80.5 Idiopathic osteoporosis with pathological fracture	0.000	0.998	0.002
Y42.0 Glucocorticoids and synthetic analogs	0.000	0.998	0.002
O10.9 Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
O10.4 Pre-existing secondary hypertension complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
O10.3 Pre-existing hypertensive heart and renal disease complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
O10.2 Pre-existing hypertensive renal disease complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
O10.1 Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
Y40 Systemic antibiotics	0.000	0.998	0.002
Y52.3 Coronary vasodilators, not elsewhere classified	0.000	0.998	0.002
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.002	0.998	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.000	0.998	0.002
Y49.5 Other antipsychotics and neuroleptics	0.000	0.998	0.002
Y42.7 Androgens and anabolic congeners	0.000	0.998	0.002
K75.4 Autoimmune hepatitis	0.002	0.998	0.000
M80.0 Postmenopausal osteoporosis with pathological fracture	0.000	0.998	0.002
W55.0 Home	0.002	0.998	0.000
M80.29 Osteoporosis of disuse with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.28 Osteoporosis of disuse with pathological fracture (Other)	0.000	0.998	0.002
M80.27 Osteoporosis of disuse with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.26 Osteoporosis of disuse with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.25 Osteoporosis of disuse with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.24 Osteoporosis of disuse with pathological fracture (Hand)	0.000	0.998	0.002
M80.23 Osteoporosis of disuse with pathological fracture (Forearm)	0.000	0.998	0.002
M80.22 Osteoporosis of disuse with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.21 Osteoporosis of disuse with pathological fracture (Shoulder region)	0.000	0.998	0.002
M80.20 Osteoporosis of disuse with pathological fracture (Multiple sites)	0.000	0.998	0.002
M80.39 Postsurgical malabsorption osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.38 Postsurgical malabsorption osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.37 Postsurgical malabsorption osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.36 Postsurgical malabsorption osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.35 Postsurgical malabsorption osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.34 Postsurgical malabsorption osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.33 Postsurgical malabsorption osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.32 Postsurgical malabsorption osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.31 Postsurgical malabsorption osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
M80.30 Postsurgical malabsorption osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.002
M80.49 Drug-induced osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.48 Drug-induced osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.47 Drug-induced osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.46 Drug-induced osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.45 Drug-induced osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.44 Drug-induced osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.43 Drug-induced osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.42 Drug-induced osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.41 Drug-induced osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
M80.40 Drug-induced osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.002
K83.5 Biliary cyst	0.000	0.998	0.002
Y40.1 Cefalosporins and other -lactam antibiotics	0.000	0.998	0.002
Y48.5 Therapeutic gases	0.000	0.998	0.002
Y48.1 Parenteral anaesthetics	0.000	0.998	0.002
Y48.0 Inhaled anaesthetics	0.000	0.998	0.002
O15.9 Eclampsia, unspecified as to time period	0.002	0.998	0.000
O15.2 Eclampsia in the puerperium	0.002	0.998	0.000
O15.1 Eclampsia in labour	0.002	0.998	0.000
O15.0 Eclampsia in pregnancy	0.002	0.998	0.000
K83.4 Spasm of sphincter of Oddi	0.000	0.998	0.002
O14.0 Moderate preeclampsia	0.002	0.998	0.000
Y52.1 Calcium-channel blockers	0.000	0.998	0.002
N13.9 Obstructive and reflux uropathy, unspecified	0.000	0.998	0.002
Y48.3 Local anaesthetics	0.000	0.998	0.002
Y42.1 Thyroid hormones and substitutes	0.000	0.998	0.002
S82.30 Fracture of lower end of tibia (closed)	0.000	0.998	0.002
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.000	0.998	0.002
Y40.3 Macrolides	0.000	0.998	0.002
Y42.9 Other and unspecified hormone antagonists	0.000	0.998	0.002
Y42.4 Oral contraceptives	0.000	0.998	0.002
Y42.2 Antithyroid drugs	0.000	0.998	0.002
M65.44 Radial styloid tenosynovitis [de Quervain] (Hand)	0.002	0.998	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.000	0.998	0.002
Y52.8 Antivaricose drugs, including sclerosing agents	0.000	0.998	0.002
Y52.7 Peripheral vasodilators	0.000	0.998	0.002
R72 Abnormality of white blood cells, not elsewhere classified	0.002	0.998	0.000
Z96.5 Presence of tooth-root and mandibular implants	0.000	0.998	0.002
Z96.4 Presence of endocrine implants	0.000	0.998	0.002
Z96.3 Presence of artificial larynx	0.000	0.998	0.002
Y49 Psychotropic drugs, not elsewhere classified	0.000	0.998	0.002
M77.57 Other enthesopathy of foot-Ankle/Foot	0.002	0.998	0.000
H44.0 Purulent endophthalmitis	0.002	0.998	0.000
H72.0 Central perforation of tympanic membrane	0.002	0.998	0.000
I44.1 Atrioventricular block, second degree	0.000	0.998	0.002
K11.8 Other diseases of salivary glands	0.002	0.998	0.000
Y40.5 Aminoglycosides	0.000	0.998	0.002
Y54.5 Other diuretics	0.000	0.998	0.002
Y47 Sedatives, hypnotics and antianxiety drugs	0.000	0.998	0.002
O14.2 HELLP syndrome	0.002	0.998	0.000
H43-H45 Disorders of vitreous body and globe	0.002	0.998	0.000
M80.89 Other osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.86 Other osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.84 Other osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.83 Other osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.82 Other osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.81 Other osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
M80.80 Other osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.002
D12.4 Descending colon	0.002	0.998	0.000
Y43.0 Antiallergic and antiemetic drugs	0.000	0.998	0.002
Y47.1 Benzodiazepines	0.000	0.998	0.002
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.58 Idiopathic osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
G62.9 Polyneuropathy, unspecified	0.002	0.998	0.000
Y43.1 Antineoplastic antimetabolites	0.000	0.998	0.002
Y43 Primarily systemic agents	0.000	0.998	0.002
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)	0.000	0.998	0.002
Y53 Agents primarily affecting the gastro-intestinal system	0.000	0.998	0.002
Y40.2 Chloramphenicol group	0.000	0.998	0.002
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.000	0.998	0.002
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.000	0.998	0.002
S32.5 Fracture of pubis	0.000	0.998	0.002
Y58 Bacterial vaccines	0.000	0.998	0.002
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
N36.3 Prolapsed urethral mucosa	0.002	0.998	0.000
Z96.0 Presence of urogenital implants	0.000	0.998	0.002
M80.09 Postmenopausal osteoporosis with pathological fracture (Site unspecified)	0.000	0.998	0.002
M80.08 Postmenopausal osteoporosis with pathological fracture (Other)	0.000	0.998	0.002
M80.07 Postmenopausal osteoporosis with pathological fracture (Ankle and foot)	0.000	0.998	0.002
M80.06 Postmenopausal osteoporosis with pathological fracture (Lower leg)	0.000	0.998	0.002
M80.05 Postmenopausal osteoporosis with pathological fracture (Pelvic region and thigh)	0.000	0.998	0.002
M80.04 Postmenopausal osteoporosis with pathological fracture (Hand)	0.000	0.998	0.002
M80.03 Postmenopausal osteoporosis with pathological fracture (Forearm)	0.000	0.998	0.002
M80.02 Postmenopausal osteoporosis with pathological fracture (Upper arm)	0.000	0.998	0.002
M80.01 Postmenopausal osteoporosis with pathological fracture (Shoulder region)	0.000	0.998	0.002
Y42.5 Other oestrogens and progestogens	0.000	0.998	0.002
Y53.4 Other laxatives	0.000	0.998	0.002
K83.1 Obstruction of bile duct	0.000	0.998	0.002
O12.0 Gestational oedema	0.002	0.998	0.000
Y40.6 Rifamycins	0.000	0.998	0.002
Z96.7 Presence of other bone and tendon implants	0.000	0.998	0.002
O14.1 Severe preeclampsia	0.002	0.998	0.000
O12.2 Gestational oedema with proteinuria	0.002	0.998	0.000
Y58.0 BCG vaccine	0.000	0.998	0.002
G63.2 Diabetic polyneuropathy	0.002	0.998	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.000	0.998	0.002
H45 Disorders of vitreous body and globe in diseases classified elsewhere	0.002	0.998	0.000
W55.8 Other specified place	0.002	0.998	0.000
Y43.4 Immunosuppressive agents	0.000	0.998	0.002
Y50 Central nervous system stimulants, not elsewhere classified	0.000	0.998	0.002
J02.9 Acute pharyngitis, unspecified	0.000	0.998	0.002
N36.9 Urethral disorder, unspecified	0.002	0.998	0.000
Y49.9 Psychotropic drug, unspecified	0.000	0.998	0.002
Y49.8 Other psychotropic drugs, not elsewhere classified	0.000	0.998	0.002
Y49.7 Psychostimulants with abuse potential	0.000	0.998	0.002
Y49.6 Psychodysleptics [hallucinogens]	0.000	0.998	0.002
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.000	0.998	0.002
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.000	0.998	0.002
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.000	0.998	0.002
M80.88 Other osteoporosis with pathological fracture (Other)	0.001	0.998	0.001
D50.8 Other iron deficiency anaemias	0.000	0.998	0.002
N36.8 Other specified disorders of urethra	0.002	0.998	0.000
Q50.4 Embryonic cyst of Fallopian tube	0.002	0.998	0.000
H44 Disorders of globe	0.002	0.998	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.000	0.998	0.002
G55.3 Nerve root and plexus compressions in other dorsopathies	0.002	0.998	0.000
K75.0 Abscess of liver	0.001	0.998	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.000	0.998	0.002
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.000	0.998	0.002
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.000	0.998	0.002
Y47.4 Bromine compounds	0.000	0.998	0.002
Y47.3 Paraldehyde	0.000	0.998	0.002
Y47.2 Chloral derivatives	0.000	0.998	0.002
Y47.0 Barbiturates, not elsewhere classified	0.000	0.998	0.002
K86.0 Alcohol-induced chronic pancreatitis	0.000	0.998	0.002
Y49.2 Other and unspecified antidepressants	0.000	0.998	0.002
Z94.4 Liver transplant status	0.002	0.998	0.000
Q12.0 Congenital cataract	0.002	0.998	0.000
Q24.8 Other specified congenital malformations of heart	0.000	0.998	0.002
S46.0 Injury of tendon of the rotator cuff of shoulder	0.000	0.998	0.002
Y40.4 Tetracyclines	0.000	0.998	0.002
Y43.9 Primarily systemic agent, unspecified	0.000	0.998	0.002
Y43.8 Other primarily systemic agents, not elsewhere classified	0.000	0.998	0.002
Y43.6 Enzymes, not elsewhere classified	0.000	0.998	0.002
Y43.5 Acidifying and alkalising agents	0.000	0.998	0.002
Y43.2 Antineoplastic natural products	0.000	0.998	0.002
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.000	0.998	0.002
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.001	0.998	0.001
Y40.7 Antifungal antibiotics, systemically used	0.000	0.998	0.001
Y40.0 Penicillins	0.000	0.998	0.002
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.000	0.998	0.002
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.000	0.998	0.002
Y53.7 Emetics	0.000	0.998	0.002
Y53.6 Antidiarrhoeal drugs	0.000	0.998	0.002
Y53.5 Digestants	0.000	0.998	0.002
Y53.3 Saline and osmotic laxatives	0.000	0.998	0.002
Y53.2 Stimulant laxatives	0.000	0.998	0.002
Y53.0 Histamine H2-receptor antagonists	0.000	0.998	0.002
S32.10 Fracture of sacrum (closed)	0.000	0.998	0.002
S32.51 Fracture of pubis (open)	0.000	0.998	0.002
E28.3 Primary ovarian failure	0.000	0.998	0.002
Q87.4 Marfan's syndrome	0.002	0.998	0.000
S46.2 Injury of muscle and tendon of other parts of biceps	0.000	0.998	0.002
Y54.9 Mineral salts, not elsewhere classified	0.000	0.998	0.002
Y54.7 Agents affecting calcification	0.000	0.998	0.002
Y54.6 Electrolytic, caloric and water-balance agents	0.000	0.998	0.002
Y54.3 Benzothiadiazine derivatives	0.000	0.998	0.002
Y54.2 Carbonic-anhydrase inhibitors	0.000	0.998	0.002
Y54.0 Mineralocorticoids	0.000	0.998	0.002
Y52.4 Angiotensin-converting-enzyme inhibitors	0.000	0.998	0.002
Y54.4 Loop [high-ceiling] diuretics	0.000	0.998	0.002
Y58.9 Other and unspecified bacterial vaccines	0.000	0.998	0.002
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.000	0.998	0.002
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.000	0.998	0.002
Y58.5 Diphtheria vaccine	0.000	0.998	0.002
Y58.4 Tetanus vaccine	0.000	0.998	0.002
Y58.3 Plague vaccine	0.000	0.998	0.002
Y58.2 Cholera vaccine	0.000	0.998	0.002
Y58.1 Typhoid and paratyphoid vaccine	0.000	0.998	0.002
N31 Neuromuscular dysfunction of bladder, not elsewhere classified	0.002	0.998	0.000
H45.0 Vitreous haemorrhage in diseases classified elsewhere	0.002	0.998	0.000
O12.1 Gestational proteinuria	0.001	0.998	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.000	0.998	0.002
W55 Bitten or struck by other mammals	0.002	0.998	0.000
E29.1 Testicular hypofunction	0.000	0.998	0.002
N31.1 Reflex neuropathic bladder, not elsewhere classified	0.002	0.998	0.000
T85.4 Mechanical complication of breast prosthesis and implant	0.000	0.998	0.002
Y54.8 Agents affecting uric acid metabolism	0.000	0.998	0.002
Z29.2 Other prophylactic chemotherapy	0.000	0.998	0.002
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.000	0.998	0.001
H20.9 Iridocyclitis, unspecified	0.002	0.998	0.000
H44.5 Degenerated conditions of globe	0.001	0.998	0.000
H45.8 Other disorders of vitreous body and globe in diseases classified elsewhere	0.001	0.998	0.000
H45.1 Endophthalmitis in diseases classified elsewhere	0.001	0.998	0.000
Y50.9 Central nervous system stimulant, unspecified	0.000	0.998	0.001
Y50.8 Other central nervous system stimulants	0.000	0.998	0.001
Y50.2 Methylxanthines, not elsewhere classified	0.000	0.998	0.001
Y50.1 Opioid receptor antagonists	0.000	0.998	0.001
Y50.0 Analeptics	0.000	0.998	0.001
H44.9 Disorder of globe, unspecified	0.001	0.998	0.000
R22.0 Localised swelling, mass and lump, head	0.000	0.998	0.002
H44.7 Retained (old) intraocular foreign body, nonmagnetic	0.001	0.998	0.000
H44.6 Retained (old) intraocular foreign body, magnetic	0.001	0.998	0.000
H44.3 Other degenerative disorders of globe	0.001	0.998	0.000
I45.6 Preexcitation syndrome	0.000	0.998	0.002
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified	0.000	0.998	0.001
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.000	0.998	0.001
Y55.6 Antiasthmatics, not elsewhere classified	0.000	0.998	0.001
Y55.5 Anticommon cold drugs	0.000	0.998	0.001
Y55.3 Antitussives	0.000	0.998	0.001
Y55.2 Other and unspecified agents primarily acting on muscles	0.000	0.998	0.001
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.000	0.998	0.001
Y55.0 Oxytocic drugs	0.000	0.998	0.001
N36 Other disorders of urethra	0.002	0.998	0.000
Y59 Other and unspecified vaccines and biological substances	0.000	0.998	0.001
N70.1 Chronic salpingitis and oophoritis	0.000	0.998	0.002
Y49.0 Tricyclic and tetracyclic antidepressants	0.000	0.998	0.001
O14.9 Preeclampsia, unspecified	0.001	0.998	0.000
Y44 Agents primarily affecting blood constituents	0.000	0.998	0.001
N83.0 Follicular cyst of ovary	0.002	0.998	0.000
N31.0 Uninhibited neuropathic bladder, not elsewhere classified	0.001	0.998	0.000
Y55.4 Expectorants	0.000	0.998	0.001
E23.7 Disorder of pituitary gland, unspecified	0.000	0.999	0.001
M22.8 Other disorders of patella	0.000	0.999	0.001
W55.9 Unspecified place	0.001	0.999	0.000
W55.5 Trade and service area	0.001	0.999	0.000
W55.6 Industrial and construction area	0.001	0.999	0.000
W55.4 Street and highway	0.001	0.999	0.000
W55.3 Sports and athletics area	0.001	0.999	0.000
W55.2 School, other institution and public administrative area	0.001	0.999	0.000
W55.1 Residential institution	0.001	0.999	0.000
Y44.5 Thrombolytic drugs	0.000	0.999	0.001
Y41 Other systemic anti-infectives and antiparasitics	0.000	0.999	0.001
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.000	0.999	0.001
E20.9 Hypoparathyroidism, unspecified	0.001	0.999	0.000
I82.9 Embolism and thrombosis of unspecified vein	0.000	0.999	0.001
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.000	0.999	0.001
E23.6 Other disorders of pituitary gland	0.000	0.999	0.001
O32.5 Maternal care for multiple gestation with malpresentation of one foetus or more	0.001	0.999	0.000
Q15.0 Congenital glaucoma	0.001	0.999	0.000
R44.1 Visual hallucinations	0.001	0.999	0.000
G63 Polyneuropathy in diseases classified elsewhere	0.001	0.999	0.000
Q12 Congenital lens malformations	0.001	0.999	0.000
E23.2 Diabetes insipidus	0.000	0.999	0.001
H44.8 Other disorders of globe	0.001	0.999	0.000
H44.4 Hypotony of eye	0.001	0.999	0.000
Q66.8 Other congenital deformities of feet	0.000	0.999	0.001
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.000	0.999	0.001
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.000	0.999	0.001
H69.9 Eustachian tube disorder, unspecified	0.000	0.999	0.001
E29 Testicular dysfunction	0.000	0.999	0.001
R73 Elevated blood glucose level	0.001	0.999	0.000
T36.0 Penicillins	0.001	0.999	0.000
U80 Agent resistant to penicillin and related antibiotics	0.001	0.999	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.000	0.999	0.001
C80.9 Malignant neoplasm, unspecified	0.001	0.999	0.000
H11.8 Other specified disorders of conjunctiva	0.001	0.999	0.000
W55.7 Farm	0.001	0.999	0.000
Y59.9 Vaccine or biological substance, unspecified	0.000	0.999	0.001
Y59.8 Other specified vaccines and biological substances	0.000	0.999	0.001
Y59.2 Protozoal vaccines	0.000	0.999	0.001
Y59.1 Rickettsial vaccines	0.000	0.999	0.001
Z96.2 Presence of otological and audiological implants	0.000	0.999	0.001
E23 Hypofunction and other disorders of pituitary gland	0.000	0.999	0.001
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.001	0.999	0.000
M65.43 Radial styloid tenosynovitis [de Quervain] (Forearm)	0.001	0.999	0.000
H44.2 Degenerative myopia	0.001	0.999	0.000
Y40.9 Systemic antibiotic, unspecified	0.000	0.999	0.001
Y44.9 Other and unspecified agents affecting blood constituents	0.000	0.999	0.001
Y44.7 Plasma substitutes	0.000	0.999	0.001
Y44.6 Natural blood and blood products	0.000	0.999	0.001
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.000	0.999	0.001
N31.2 Flaccid neuropathic bladder, not elsewhere classified	0.001	0.999	0.000
Q17.5 Prominent ear	0.001	0.999	0.000
S46 Injury of muscle and tendon at shoulder and upper arm level	0.000	0.999	0.001
S12.90 Fracture of neck, part unspecified (closed)	0.001	0.999	0.000
W55.58 Bitten or struck by other mammals; Trade and service area;While engaged in other specified activities	0.001	0.999	0.000
W55.99 Bitten or struck by other mammals: Unspecified place: During unspecified activity	0.001	0.999	0.000
H11.2 Conjunctival scars	0.001	0.999	0.000
I69.3 Sequelae of cerebral infarction	0.000	0.999	0.001
O32.8 Maternal care for other malpresentation of foetus	0.001	0.999	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.000	0.999	0.001
Y41.4 Anthelminthics	0.000	0.999	0.001
Y41.3 Other antiprotozoal drugs	0.000	0.999	0.001
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.000	0.999	0.001
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.000	0.999	0.001
Y57.8 Other drugs and medicaments	0.000	0.999	0.001
Y57 Other and unspecified drugs and medicaments	0.000	0.999	0.001
G63.8 Polyneuropathy in other diseases classified elsewhere	0.001	0.999	0.000
G63.6 Polyneuropathy in other musculoskeletal disorders	0.001	0.999	0.000
G63.5 Polyneuropathy in systemic connective tissue disorders	0.001	0.999	0.000
G63.4 Polyneuropathy in nutritional deficiency	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations