TreeWAS – Variant ID: rs249954

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Showing all nodes without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
Z45.2 Adjustment and management of vascular access device	0.664	0.336	0.000
Z45 Adjustment and management of implanted device	0.559	0.441	0.000
Z45.8 Adjustment and management of other implanted devices	0.529	0.471	0.000
Z45.1 Adjustment and management of infusion pump	0.512	0.488	0.000
Z45.9 Adjustment and management of unspecified implanted device	0.409	0.591	0.000
Z45.3 Adjustment and management of implanted hearing device	0.386	0.614	0.000
Z45.0 Adjustment and management of cardiac pacemaker	0.199	0.801	0.000
D70 Agranulocytosis	0.059	0.941	0.000
D75 Other diseases of blood and blood-forming organs	0.053	0.947	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.053	0.947	0.000
D75.8 Other specified diseases of blood and blood-forming organs	0.052	0.948	0.000
D75.0 Familial erythrocytosis	0.047	0.953	0.000
D75.1 Secondary polycythaemia	0.046	0.954	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.045	0.955	0.000
D73 Diseases of spleen	0.040	0.960	0.000
D76.3 Other histiocytosis syndromes	0.039	0.961	0.000
D74 Methaemoglobinaemia	0.038	0.962	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.038	0.962	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.038	0.962	0.000
D73.9 Disease of spleen, unspecified	0.036	0.964	0.000
D75.2 Essential thrombocytosis	0.035	0.965	0.000
D73.3 Abscess of spleen	0.035	0.965	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.032	0.968	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.032	0.968	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.032	0.968	0.000
D73.4 Cyst of spleen	0.029	0.971	0.000
D73.2 Chronic congestive splenomegaly	0.029	0.971	0.000
D73.1 Hypersplenism	0.028	0.971	0.000
D73.5 Infarction of spleen	0.028	0.972	0.000
D74.9 Methaemoglobinaemia, unspecified	0.027	0.972	0.000
D74.8 Other methaemoglobinaemias	0.027	0.972	0.000
D74.0 Congenital methaemoglobinaemia	0.027	0.972	0.000
D73.8 Other diseases of spleen	0.027	0.973	0.000
D72 Other disorders of white blood cells	0.026	0.974	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.023	0.976	0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.020	0.980	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.019	0.981	0.000
D72.9 Disorder of white blood cells, unspecified	0.019	0.981	0.000
D72.0 Genetic anomalies of leukocytes	0.019	0.981	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.018	0.982	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.018	0.982	0.000
C85.7 Other specified types of non-Hodgkin's lymphoma	0.018	0.982	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.017	0.983	0.000
Y43 Primarily systemic agents	0.017	0.983	0.000
D72.1 Eosinophilia	0.016	0.984	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.016	0.984	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.016	0.984	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.016	0.984	0.000
Y43.4 Immunosuppressive agents	0.016	0.984	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.016	0.984	0.000
Y57 Other and unspecified drugs and medicaments	0.016	0.984	0.000
Y48 Anaesthetics and therapeutic gases	0.015	0.985	0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.015	0.985	0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma	0.015	0.985	0.000
Y45.0 Opioids and related analgesics	0.015	0.985	0.000
Y41.5 Antiviral drugs	0.015	0.985	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.015	0.985	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.015	0.985	0.000
Y43.3 Other antineoplastic drugs	0.015	0.985	0.000
Y45.2 Propionic acid derivatives	0.015	0.985	0.000
C95 Leukaemia of unspecified cell type	0.015	0.985	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.014	0.985	0.000
A41.9 Septicaemia, unspecified	0.015	0.985	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.014	0.986	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.014	0.986	0.000
Y54.3 Benzothiadiazine derivatives	0.014	0.986	0.000
C81 Hodgkin's disease	0.014	0.986	0.000
Y48.4 Anaesthetic, unspecified	0.014	0.986	0.000
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.014	0.986	0.000
C85.0 Lymphosarcoma	0.014	0.986	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.014	0.986	0.000
Y58 Bacterial vaccines	0.014	0.986	0.000
Y57.9 Drug or medicament, unspecified	0.014	0.986	0.000
Y41.0 Sulphonamides	0.014	0.986	0.000
C86 Other specified types of T/NK-cell lymphoma	0.013	0.986	0.000
C95.9 Leukaemia, unspecified	0.013	0.987	0.000
Y59 Other and unspecified vaccines and biological substances	0.013	0.987	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.013	0.987	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.013	0.987	0.000
Y41.4 Anthelminthics	0.013	0.987	0.000
Y41.3 Other antiprotozoal drugs	0.013	0.987	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.013	0.987	0.000
Y41.1 Antimycobacterial drugs	0.013	0.987	0.000
Y57.8 Other drugs and medicaments	0.013	0.987	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.013	0.987	0.000
C90 Multiple myeloma and malignant plasma cell neoplasms	0.013	0.987	0.000
Y45.8 Other analgesics and antipyretics	0.013	0.987	0.000
Y54.4 Loop [high-ceiling] diuretics	0.013	0.987	0.000
C82.4 Follicular lymphoma grade IIIb	0.013	0.987	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.013	0.987	0.000
C81.1 Nodular sclerosis	0.013	0.987	0.000
O69.1 Labour and delivery complicated by cord around neck, with compression	0.013	0.987	0.000
F10.0 Acute intoxication	0.000	0.988	0.012
Y47.1 Benzodiazepines	0.012	0.988	0.000
C85.1 B-cell lymphoma, unspecified	0.012	0.988	0.000
Y43.9 Primarily systemic agent, unspecified	0.012	0.988	0.000
Y43.8 Other primarily systemic agents, not elsewhere classified	0.012	0.988	0.000
Y43.6 Enzymes, not elsewhere classified	0.012	0.988	0.000
Y43.5 Acidifying and alkalising agents	0.012	0.988	0.000
Y43.2 Antineoplastic natural products	0.012	0.988	0.000
Y54.8 Agents affecting uric acid metabolism	0.012	0.988	0.000
D72.8 Other specified disorders of white blood cells	0.012	0.988	0.000
C93 Monocytic leukaemia	0.012	0.988	0.000
Y54.7 Agents affecting calcification	0.012	0.988	0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.012	0.988	0.000
C94 Other leukaemias of specified cell type	0.012	0.988	0.000
Y49.5 Other antipsychotics and neuroleptics	0.012	0.988	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.012	0.988	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.012	0.988	0.000
Y54.9 Mineral salts, not elsewhere classified	0.012	0.988	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.012	0.988	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.012	0.988	0.000
Y54.0 Mineralocorticoids	0.012	0.988	0.000
Y57.5 X-ray contrast media	0.012	0.988	0.000
Y53.4 Other laxatives	0.012	0.988	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.012	0.988	0.000
Y45.5 4-Aminophenol derivatives	0.012	0.988	0.000
Y45.4 Antirheumatics	0.012	0.988	0.000
Y56.9 Topical agent, unspecified	0.012	0.988	0.000
Y56.8 Other topical agents	0.012	0.988	0.000
Y56.7 Dental drugs, topically applied	0.012	0.988	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.012	0.988	0.000
Y56.5 Ophthalmological drugs and preparations	0.012	0.988	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.012	0.988	0.000
Y56.3 Emollients, demulcents and protectants	0.012	0.988	0.000
Y56.2 Local astringents and local detergents	0.012	0.988	0.000
Y56.1 Antipruritics	0.012	0.988	0.000
Y49.2 Other and unspecified antidepressants	0.012	0.988	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.012	0.988	0.000
C86.5 Angioimmunoblastic T-cell lymphoma	0.012	0.988	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.012	0.988	0.000
Y57.7 Vitamins, not elsewhere classified	0.011	0.989	0.000
Y57.4 Pharmaceutical excipients	0.011	0.989	0.000
Y57.3 Alcohol deterrents	0.011	0.989	0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified	0.011	0.989	0.000
Y57.1 Lipotropic drugs	0.011	0.989	0.000
Y57.0 Appetite depressants [anorectics]	0.011	0.989	0.000
C81.0 Lymphocytic predominance	0.011	0.989	0.000
Y48.5 Therapeutic gases	0.011	0.989	0.000
Y48.1 Parenteral anaesthetics	0.011	0.989	0.000
Y48.0 Inhaled anaesthetics	0.011	0.989	0.000
Y48.3 Local anaesthetics	0.011	0.989	0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.011	0.989	0.000
C82.6 Cutaneous follicle centre lymphoma	0.011	0.989	0.000
C82.5 Diffuse follicle centre lymphoma	0.011	0.989	0.000
C82.3 Follicular lymphoma grade IIIa	0.011	0.989	0.000
C90.3 Solitary plasmacytoma	0.011	0.989	0.000
C82.2 Large cell, follicular	0.011	0.989	0.000
C82.0 Small cleaved cell, follicular	0.011	0.989	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.011	0.989	0.000
Y58.0 BCG vaccine	0.011	0.989	0.000
C83.0 Small cell (diffuse)	0.011	0.989	0.000
Y49.9 Psychotropic drug, unspecified	0.011	0.989	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.011	0.989	0.000
Y49.7 Psychostimulants with abuse potential	0.011	0.989	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.011	0.989	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.011	0.989	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.011	0.989	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.011	0.989	0.000
Y43.0 Antiallergic and antiemetic drugs	0.011	0.989	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.011	0.989	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.011	0.989	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.011	0.989	0.000
Y47.4 Bromine compounds	0.011	0.989	0.000
Y47.3 Paraldehyde	0.011	0.989	0.000
Y47.2 Chloral derivatives	0.011	0.989	0.000
Y47.0 Barbiturates, not elsewhere classified	0.011	0.989	0.000
C95.7 Other leukaemia of unspecified cell type	0.011	0.989	0.000
C95.2 Subacute leukaemia of unspecified cell type	0.011	0.989	0.000
C95.1 Chronic leukaemia of unspecified cell type	0.011	0.989	0.000
C95.0 Acute leukaemia of unspecified cell type	0.011	0.989	0.000
Y46.7 Anti-Parkinsonism drugs	0.011	0.989	0.000
Y48.2 Other and unspecified general anaesthetics	0.011	0.989	0.000
Y46.2 Hydantoin derivatives	0.011	0.989	0.000
C81.2 Mixed cellularity	0.011	0.989	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.010	0.989	0.000
Y55.5 Anticommon cold drugs	0.010	0.989	0.000
Y55.4 Expectorants	0.010	0.989	0.000
Y55.3 Antitussives	0.010	0.989	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.010	0.989	0.000
Y55.0 Oxytocic drugs	0.010	0.989	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.010	0.989	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.010	0.989	0.000
Y53.7 Emetics	0.010	0.989	0.000
Y53.6 Antidiarrhoeal drugs	0.010	0.989	0.000
Y53.5 Digestants	0.010	0.989	0.000
Y53.3 Saline and osmotic laxatives	0.010	0.989	0.000
Y53.2 Stimulant laxatives	0.010	0.989	0.000
Y53.0 Histamine H2-receptor antagonists	0.010	0.989	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.010	0.989	0.000
C81.7 Other Hodgkin's disease	0.010	0.990	0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma	0.010	0.990	0.000
C81.3 Lymphocytic depletion	0.010	0.990	0.000
C84.0 Mycosis fungoides	0.010	0.990	0.000
C88 Malignant immunoproliferative diseases	0.010	0.990	0.000
Y58.9 Other and unspecified bacterial vaccines	0.010	0.990	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.010	0.990	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.010	0.990	0.000
Y58.5 Diphtheria vaccine	0.010	0.990	0.000
Y58.4 Tetanus vaccine	0.010	0.990	0.000
Y58.3 Plague vaccine	0.010	0.990	0.000
Y58.2 Cholera vaccine	0.010	0.990	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.010	0.990	0.000
A41 Other septicaemia	0.010	0.990	0.000
Y40 Systemic antibiotics	0.010	0.990	0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations	0.010	0.990	0.000
C86.4 Blastic NK-cell lymphoma	0.010	0.990	0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma	0.010	0.990	0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma	0.010	0.990	0.000
C86.1 Hepatosplenic T-cell lymphoma	0.010	0.990	0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type	0.010	0.990	0.000
Y59.3 Immunoglobulin	0.010	0.990	0.000
C92 Myeloid leukaemia	0.010	0.990	0.000
C84.4 Peripheral T-cell lymphoma	0.010	0.990	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.010	0.990	0.000
C84.8 Cutaneous T-cell lymphoma, unspecified	0.010	0.990	0.000
Y43.1 Antineoplastic antimetabolites	0.010	0.990	0.000
Y59.9 Vaccine or biological substance, unspecified	0.010	0.990	0.000
Y59.8 Other specified vaccines and biological substances	0.010	0.990	0.000
Y59.2 Protozoal vaccines	0.010	0.990	0.000
Y59.1 Rickettsial vaccines	0.010	0.990	0.000
Y59.0 Viral vaccines	0.010	0.990	0.000
C90.2 Plasmacytoma, extramedullary	0.010	0.990	0.000
Y46.8 Antispasticity drugs	0.010	0.990	0.000
Y46.5 Valproic acid	0.010	0.990	0.000
Y46.3 Deoxybarbiturates	0.010	0.990	0.000
Y46.1 Oxazolidinediones	0.010	0.990	0.000
Y46.0 Succinimides	0.010	0.990	0.000
Y44 Agents primarily affecting blood constituents	0.010	0.990	0.000
Y50.9 Central nervous system stimulant, unspecified	0.009	0.990	0.000
Y50.8 Other central nervous system stimulants	0.009	0.990	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.009	0.990	0.000
Y50.1 Opioid receptor antagonists	0.009	0.990	0.000
Y50.0 Analeptics	0.009	0.990	0.000
C90.1 Plasma cell leukaemia	0.009	0.990	0.000
Y46.6 Other and unspecified antiepileptics	0.009	0.990	0.000
C84.9 Mature T/NK-cell lymphoma, unspecified	0.009	0.991	0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative	0.009	0.991	0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive	0.009	0.991	0.000
C84.3 Lymphoepithelioid lymphoma	0.009	0.991	0.000
C84.2 T-zone lymphoma	0.009	0.991	0.000
C84.1 Sezary's diease	0.009	0.991	0.000
A41.8 Other specified septicaemia	0.009	0.991	0.000
C93.1 Chronic monocytic leukaemia	0.009	0.991	0.000
D73.0 Hyposplenism	0.009	0.991	0.000
C93.9 Monocytic leukaemia, unspecified	0.009	0.991	0.000
C93.7 Other monocytic leukaemia	0.009	0.991	0.000
C93.3 Juvenile myelomonocytic leukaemia	0.009	0.991	0.000
C93.2 Subacute monocytic leukaemia	0.009	0.991	0.000
C93.0 Acute monocytic leukaemia	0.009	0.991	0.000
Y57.6 Other diagnostic agents	0.009	0.991	0.000
C94.7 Other specified leukaemias	0.009	0.991	0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified	0.009	0.991	0.000
C94.5 Acute myelofibrosis	0.009	0.991	0.000
C94.4 Acute panmyelosis	0.009	0.991	0.000
C94.3 Mast cell leukaemia	0.009	0.991	0.000
C94.2 Acute megakaryoblastic leukaemia	0.009	0.991	0.000
C94.1 Chronic erythraemia	0.009	0.991	0.000
C94.0 Acute erythraemia and erythroleukaemia	0.009	0.991	0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified	0.009	0.991	0.000
C96.8 Histiocytic sarcoma	0.009	0.991	0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.009	0.991	0.000
C96.6 Unifocal Langerhans-cell histiocytosis	0.009	0.991	0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis	0.009	0.991	0.000
C96.4 Sarcoma of dendritic cells (accessory cells)	0.009	0.991	0.000
C96.3 True histiocytic lymphoma	0.009	0.991	0.000
C96.2 Malignant mast cell tumour	0.009	0.991	0.000
C96.1 Malignant histiocytosis	0.009	0.991	0.000
C96.0 Letterer-Siwe disease	0.009	0.991	0.000
A41.1 Septicaemia due to other specified staphylococcus	0.009	0.991	0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified	0.009	0.991	0.000
C83.6 Undifferentiated (diffuse)	0.009	0.991	0.000
C83.5 Lymphoblastic (diffuse)	0.009	0.991	0.000
C83.4 Immunoblastic (diffuse)	0.009	0.991	0.000
C83.2 Mixed small and large cell (diffuse)	0.009	0.991	0.000
C81.9 Hodgkin's disease, unspecified	0.009	0.991	0.000
A41.2 Septicaemia due to unspecified staphylococcus	0.009	0.991	0.000
C83.7 Burkitt's tumour	0.008	0.991	0.000
Y40.8 Other systemic antibiotics	0.008	0.992	0.000
C83.8 Other types of diffuse non-Hodgkin's lymphoma	0.008	0.992	0.000
C84.5 Other and unspecified T-cell lymphomas	0.008	0.992	0.000
C92.4 Acute promyelocytic leukaemia	0.008	0.992	0.000
A41.4 Septicaemia due to anaerobes	0.008	0.992	0.000
C90.0 Multiple myeloma	0.008	0.992	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.008	0.992	0.000
Y40.7 Antifungal antibiotics, systemically used	0.008	0.992	0.000
Y46.4 Iminostilbenes	0.007	0.992	0.000
C88.9 Malignant immunoproliferative disease, unspecified	0.007	0.992	0.000
C88.7 Other malignant immunoproliferative diseases	0.007	0.992	0.000
C88.3 Immunoproliferative small intestinal disease	0.007	0.992	0.000
C88.2 Gamma heavy chain disease	0.007	0.992	0.000
C88.1 Alpha heavy chain disease	0.007	0.992	0.000
Y40.6 Rifamycins	0.008	0.992	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.007	0.992	0.000
A41.3 Septicaemia due to Haemophilus influenzae	0.007	0.992	0.000
Y40.4 Tetracyclines	0.007	0.993	0.000
Y40.2 Chloramphenicol group	0.007	0.993	0.000
C92.9 Myeloid leukaemia, unspecified	0.007	0.993	0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia	0.007	0.993	0.000
C92.7 Other myeloid leukaemia	0.007	0.993	0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality	0.007	0.993	0.000
C92.5 Acute myelomonocytic leukaemia	0.007	0.993	0.000
C92.3 Myeloid sarcoma	0.007	0.993	0.000
C92.2 Subacute myeloid leukaemia	0.007	0.993	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.007	0.993	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.007	0.993	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.007	0.993	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.007	0.993	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.007	0.993	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.007	0.993	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.007	0.993	0.000
Y51.0 Anticholinesterase agents	0.007	0.993	0.000
Y52 Agents primarily affecting the cardiovascular system	0.007	0.993	0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]	0.007	0.993	0.000
Y40.5 Aminoglycosides	0.007	0.993	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.007	0.993	0.000
Y44.7 Plasma substitutes	0.007	0.993	0.000
Y44.6 Natural blood and blood products	0.007	0.993	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.007	0.993	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.007	0.993	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.007	0.993	0.000
C83.1 Small cleaved cell (diffuse)	0.007	0.993	0.000
N31.8 Other neuromuscular dysfunction of bladder	0.000	0.993	0.007
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.007	0.993	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.007	0.993	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.007	0.993	0.000
C83.3 Large cell (diffuse)	0.007	0.993	0.000
Z29.2 Other prophylactic chemotherapy	0.007	0.993	0.000
Y44.5 Thrombolytic drugs	0.006	0.993	0.000
C88.0 Waldenstrom's macroglobulinaemia	0.006	0.994	0.000
Y40.3 Macrolides	0.006	0.994	0.000
C20 Malignant neoplasm of rectum	0.006	0.994	0.000
Y54.5 Other diuretics	0.005	0.994	0.001
S32.50 Fracture of pubis (closed)	0.000	0.994	0.006
Z22.5 Carrier of viral hepatitis	0.006	0.994	0.000
O21.0 Mild hyperemesis gravidarum	0.006	0.994	0.000
C92.0 Acute myeloid leukaemia	0.006	0.994	0.000
Y45.1 Salicylates	0.006	0.994	0.000
Z22 Carrier of infectious disease	0.006	0.994	0.000
Z29 Need for other prophylactic measures	0.006	0.994	0.000
O21 Excessive vomiting in pregnancy	0.006	0.994	0.000
C92.1 Chronic myeloid leukaemia	0.006	0.994	0.000
O23.4 Unspecified infection of urinary tract in pregnancy	0.006	0.994	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.005	0.994	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.005	0.994	0.000
Y52.7 Peripheral vasodilators	0.005	0.994	0.000
Z22.3 Carrier of other specified bacterial diseases	0.006	0.994	0.000
C91 Lymphoid leukaemia	0.005	0.994	0.000
Y40.0 Penicillins	0.005	0.995	0.000
O23 Infections of genito-urinary tract in pregnancy	0.005	0.995	0.000
O21.8 Other vomiting complicating pregnancy	0.005	0.995	0.000
A41.5 Septicaemia due to other Gram-negative organisms	0.005	0.995	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.005	0.995	0.000
Y86 Sequelae of other accidents	0.005	0.995	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.005	0.995	0.000
Z22.8 Carrier of other infectious diseases	0.005	0.995	0.000
S52.10 Fracture of upper end of radius (closed)	0.000	0.995	0.005
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.005	0.995	0.000
Y40.9 Systemic antibiotic, unspecified	0.005	0.995	0.000
O21.1 Hyperemesis gravidarum with metabolic disturbance	0.005	0.995	0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.005	0.995	0.000
Z29.0 Isolation	0.005	0.995	0.000
Y44.2 Anticoagulants	0.004	0.995	0.000
O23.9 Other and unspecified genito-urinary tract infection in pregnancy	0.005	0.995	0.000
Z29.1 Prophylactic immunotherapy	0.005	0.995	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.005	0.995	0.000
B02.9 Zoster without complication	0.005	0.995	0.000
Z22.9 Carrier of infectious disease, unspecified	0.004	0.995	0.000
Z22.6 Carrier of human T-lymphotropic virus type 1 [HTLV-1] infection	0.004	0.995	0.000
Z22.4 Carrier of infections with a predominantly sexual mode of transmission	0.004	0.995	0.000
Z22.2 Carrier of diphtheria	0.004	0.995	0.000
Z22.0 Carrier of typhoid	0.004	0.995	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.004	0.996	0.000
Y52.1 Calcium-channel blockers	0.004	0.996	0.000
O23.5 Infections of the genital tract in pregnancy	0.004	0.996	0.000
Z29.9 Prophylactic measure, unspecified	0.004	0.996	0.000
O21.2 Late vomiting of pregnancy	0.004	0.996	0.000
C91.9 Lymphoid leukaemia, unspecified	0.004	0.996	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.004	0.996	0.000
C91.0 Acute lymphoblastic leukaemia	0.004	0.996	0.000
C91.8 Mature B-cell leukaemia Burkitt-type	0.004	0.996	0.000
C91.7 Other lymphoid leukaemia	0.004	0.996	0.000
C91.6 Prolymphocytic leukaemia of T-cell type	0.004	0.996	0.000
C91.3 Prolymphocytic leukaemia	0.004	0.996	0.000
C91.2 Subacute lymphocytic leukaemia	0.004	0.996	0.000
Y52.4 Angiotensin-converting-enzyme inhibitors	0.004	0.996	0.000
Z22.1 Carrier of other intestinal infectious diseases	0.004	0.996	0.000
O23.3 Infections of other parts of urinary tract in pregnancy	0.004	0.996	0.000
O23.2 Infections of urethra in pregnancy	0.004	0.996	0.000
O23.1 Infections of bladder in pregnancy	0.004	0.996	0.000
O23.0 Infections of kidney in pregnancy	0.004	0.996	0.000
O21.9 Vomiting of pregnancy, unspecified	0.004	0.996	0.000
N73.6 Female pelvic peritoneal adhesions	0.004	0.996	0.000
C91.5 Adult T-cell leukaemia	0.004	0.996	0.000
Z29.8 Other specified prophylactic measures	0.004	0.996	0.000
D48.5 Skin	0.004	0.996	0.000
O22 Venous complications in pregnancy	0.004	0.996	0.000
Z20 Contact with and exposure to communicable diseases	0.004	0.996	0.000
Z24 Need for immunisation against certain single viral diseases	0.004	0.996	0.000
Z28 Immunisation not carried out	0.004	0.996	0.000
Z27 Need for immunisation against combinations of infectious diseases	0.004	0.996	0.000
Z26 Need for immunisation against other single infectious diseases	0.004	0.996	0.000
Z25 Need for immunisation against other single viral diseases	0.004	0.996	0.000
Z23 Need for immunisation against single bacterial diseases	0.004	0.996	0.000
A30-A49 Other bacterial diseases	0.004	0.996	0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly	0.004	0.996	0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.004	0.996	0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.004	0.996	0.000
F43.0 Acute stress reaction	0.000	0.996	0.004
H71 Cholesteatoma of middle ear	0.004	0.996	0.000
O20.8 Other haemorrhage in early pregnancy	0.004	0.996	0.000
Y87.1 Sequelae of assault	0.004	0.996	0.000
V01 Pedestrian injured in collision with pedal cycle	0.004	0.996	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.004	0.996	0.000
V01-V09 Pedestrian injured in transport accident	0.004	0.996	0.000
O22.4 Haemorrhoids in pregnancy	0.003	0.996	0.000
O29 Complications of anaesthesia during pregnancy	0.003	0.996	0.000
O25 Malnutrition in pregnancy	0.003	0.996	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.003	0.996	0.000
Chapter XX External causes of morbidity and mortality	0.003	0.997	0.000
V01.1 Traffic accident	0.003	0.997	0.000
S32.5 Fracture of pubis	0.000	0.997	0.003
W78.2 School, other institution and public administrative area	0.003	0.997	0.000
O20 Haemorrhage in early pregnancy	0.003	0.997	0.000
C79.8 Secondary malignant neoplasm of other specified sites	0.003	0.997	0.000
A39 Meningococcal infection	0.003	0.997	0.000
O28 Abnormal findings on antenatal screening of mother	0.003	0.997	0.000
Y79.2 Prosthetic and other implants, materials and accessory devices	0.003	0.997	0.000
Y79 Orthopaedic devices associated with adverse incidents	0.003	0.997	0.000
Z20.1 Contact with and exposure to tuberculosis	0.003	0.997	0.000
W75-W84 Other accidental threats to breathing	0.003	0.997	0.000
W78 Inhalation of gastric contents	0.003	0.997	0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges	0.003	0.997	0.000
A41.0 Septicaemia due to Staphylococcus aureus	0.003	0.997	0.000
V01.9 Unspecified whether traffic or nontraffic accident	0.003	0.997	0.000
C43.5 Malignant melanoma of trunk	0.000	0.997	0.003
Z24.5 Need for immunisation against rubella alone	0.003	0.997	0.000
O24 Diabetes mellitus in pregnancy	0.003	0.997	0.000
M43.17 Spondylolisthesis (Lumbosacral region)	0.000	0.997	0.003
Y82 Other and unspecified medical devices associated with adverse incidents	0.003	0.997	0.000
C91.4 Hairy-cell leukaemia	0.003	0.997	0.000
Y77 Ophthalmic devices associated with adverse incidents	0.003	0.997	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.003	0.997	0.000
A39.0 Meningococcal meningitis	0.003	0.997	0.000
O22.9 Venous complication in pregnancy, unspecified	0.003	0.997	0.000
O22.8 Other venous complications in pregnancy	0.003	0.997	0.000
O22.5 Cerebral venous thrombosis in pregnancy	0.003	0.997	0.000
O22.3 Deep phlebothrombosis in pregnancy	0.003	0.997	0.000
O22.2 Superficial thrombophlebitis in pregnancy	0.003	0.997	0.000
O22.1 Genital varices in pregnancy	0.003	0.997	0.000
O22.0 Varicose veins of lower extremity in pregnancy	0.003	0.997	0.000
O26.8 Other specified pregnancy-related conditions	0.003	0.997	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.003	0.997	0.000
V95-V97 Air and space transport accidents	0.003	0.997	0.000
Z20.9 Contact with and exposure to unspecified communicable disease	0.003	0.997	0.000
Z20.8 Contact with and exposure to other communicable diseases	0.003	0.997	0.000
Z20.7 Contact with and exposure to pediculosis, acariasis and other infestations	0.003	0.997	0.000
Z20.6 Contact with and exposure to human immunodeficiency virus [HIV]	0.003	0.997	0.000
Z20.5 Contact with and exposure to viral hepatitis	0.003	0.997	0.000
Z20.4 Contact with and exposure to rubella	0.003	0.997	0.000
Z20.3 Contact with and exposure to rabies	0.003	0.997	0.000
Z20.2 Contact with and exposure to infections with a predominantly sexual mode of transmission	0.003	0.997	0.000
Z20.0 Contact with and exposure to intestinal infectious diseases	0.003	0.997	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.003	0.997	0.000
Y87.2 Sequelae of events of undetermined intent	0.003	0.997	0.000
Z24.6 Need for immunisation against viral hepatitis	0.003	0.997	0.000
Z24.4 Need for immunisation against measles alone	0.003	0.997	0.000
Z24.3 Need for immunisation against yellow fever	0.003	0.997	0.000
Z24.2 Need for immunisation against rabies	0.003	0.997	0.000
Z24.1 Need for immunisation against arthropod-borne viral encephalitis	0.003	0.997	0.000
Z24.0 Need for immunisation against poliomyelitis	0.003	0.997	0.000
S27.00 Traumatic pneumothorax (without open wound into thoracic cavity)	0.003	0.997	0.000
O28.3 Abnormal ultrasonic finding on antenatal screening of mother	0.003	0.997	0.000
V02 Pedestrian injured in collision with two- or three-wheeled motor vehicle	0.003	0.997	0.000
D48.6 Breast	0.003	0.997	0.000
Y87.0 Sequelae of intentional self-harm	0.003	0.997	0.000
V09 Pedestrian injured in other and unspecified transport accidents	0.003	0.997	0.000
Y42.2 Antithyroid drugs	0.003	0.997	0.000
A31 Infection due to other mycobacteria	0.003	0.997	0.000
Y82.2 Prosthetic and other implants, materials and accessory devices	0.003	0.997	0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.003	0.997	0.000
S27.30 Other injuries of lung (without open wound into thoracic cavity)	0.003	0.997	0.000
Z23.8 Need for immunisation against other single bacterial diseases	0.003	0.997	0.000
Z23.7 Need for immunisation against pertussis alone	0.003	0.997	0.000
Z23.6 Need for immunisation against diphtheria alone	0.003	0.997	0.000
Z23.5 Need for immunisation against tetanus alone	0.003	0.997	0.000
Z23.4 Need for immunisation against tularaemia	0.003	0.997	0.000
Z23.3 Need for immunisation against plague	0.003	0.997	0.000
Z23.2 Need for immunisation against tuberculosis [BCG]	0.003	0.997	0.000
Z23.1 Need for immunisation against typhoid-paratyphoid alone [TAB]	0.003	0.997	0.000
Z23.0 Need for immunisation against cholera alone	0.003	0.997	0.000
Z25.8 Need for immunisation against other specified single viral diseases	0.003	0.997	0.000
Z25.1 Need for immunisation against influenza	0.003	0.997	0.000
Z25.0 Need for immunisation against mumps alone	0.003	0.997	0.000
Z26.9 Need for immunisation against unspecified infectious disease	0.003	0.997	0.000
Z26.8 Need for immunisation against other specified single infectious diseases	0.003	0.997	0.000
Z26.0 Need for immunisation against leishmaniasis	0.003	0.997	0.000
Z27.9 Need for immunisation against unspecified combinations of infectious diseases	0.003	0.997	0.000
Z27.8 Need for immunisation against other combinations of infectious diseases	0.003	0.997	0.000
Z27.4 Need for immunisation against measles-mumps-rubella [MMR]	0.003	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations