TreeWAS – Variant ID: rs3096644

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E27 Other disorders of adrenal gland	0.291	0.709	0.000
E20-E35 Disorders of other endocrine glands	0.290	0.710	0.000
E27.1 Primary adrenocortical insufficiency	0.278	0.722	0.000
E23 Hypofunction and other disorders of pituitary gland	0.278	0.722	0.000
E23.0 Hypopituitarism	0.276	0.724	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.271	0.729	0.000
E21.3 Hyperparathyroidism, unspecified	0.264	0.736	0.000
E27.8 Other specified disorders of adrenal gland	0.261	0.739	0.000
E29 Testicular dysfunction	0.260	0.740	0.000
E22 Hyperfunction of pituitary gland	0.257	0.743	0.000
E27.2 Addisonian crisis	0.250	0.750	0.000
E27.9 Disorder of adrenal gland, unspecified	0.242	0.758	0.000
E29.1 Testicular hypofunction	0.239	0.761	0.000
E26 Hyperaldosteronism	0.230	0.770	0.000
E31 Polyglandular dysfunction	0.228	0.772	0.000
E22.0 Acromegaly and pituitary gigantism	0.225	0.775	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.209	0.791	0.000
E27.5 Adrenomedullary hyperfunction	0.209	0.791	0.000
E27.0 Other adrenocortical overactivity	0.209	0.791	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.208	0.792	0.000
E32 Diseases of thymus	0.208	0.792	0.000
E30 Disorders of puberty, not elsewhere classified	0.208	0.792	0.000
E24 Cushing's syndrome	0.208	0.792	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.208	0.792	0.000
E22.1 Hyperprolactinaemia	0.202	0.798	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.200	0.800	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.200	0.800	0.000
E23.1 Drug-induced hypopituitarism	0.200	0.800	0.000
E21.4 Other specified disorders of parathyroid gland	0.194	0.806	0.000
E21.2 Other hyperparathyroidism	0.194	0.806	0.000
E20 Hypoparathyroidism	0.194	0.806	0.000
E23.7 Disorder of pituitary gland, unspecified	0.191	0.809	0.000
E25 Adrenogenital disorders	0.190	0.810	0.000
E29.9 Testicular dysfunction, unspecified	0.187	0.813	0.000
E29.8 Other testicular dysfunction	0.187	0.813	0.000
E29.0 Testicular hyperfunction	0.187	0.813	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.184	0.815	0.000
E22.8 Other hyperfunction of pituitary gland	0.184	0.816	0.000
E23.6 Other disorders of pituitary gland	0.184	0.816	0.000
E31.0 Autoimmune polyglandular failure	0.184	0.816	0.000
E26.9 Hyperaldosteronism, unspecified	0.183	0.817	0.000
E34 Other endocrine disorders	0.179	0.821	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.174	0.826	0.000
E26.0 Primary hyperaldosteronism	0.171	0.829	0.000
E23.2 Diabetes insipidus	0.168	0.832	0.000
E24.8 Other Cushing's syndrome	0.165	0.835	0.000
E26.8 Other hyperaldosteronism	0.165	0.835	0.000
E26.1 Secondary hyperaldosteronism	0.165	0.835	0.000
E31.9 Polyglandular dysfunction, unspecified	0.164	0.836	0.000
E31.8 Other polyglandular dysfunction	0.164	0.836	0.000
E31.1 Polyglandular hyperfunction	0.164	0.836	0.000
E24.2 Drug-induced Cushing's syndrome	0.163	0.837	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.161	0.839	0.000
E21.0 Primary hyperparathyroidism	0.152	0.848	0.000
E30.9 Disorder of puberty, unspecified	0.149	0.851	0.000
E30.8 Other disorders of puberty	0.149	0.851	0.000
E30.1 Precocious puberty	0.149	0.851	0.000
E30.0 Delayed puberty	0.149	0.851	0.000
E32.9 Disease of thymus, unspecified	0.149	0.851	0.000
E32.8 Other diseases of thymus	0.149	0.851	0.000
E32.1 Abscess of thymus	0.149	0.851	0.000
E32.0 Persistent hyperplasia of thymus	0.149	0.851	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.149	0.851	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.149	0.851	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.149	0.851	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.149	0.851	0.000
E24.3 Ectopic ACTH syndrome	0.149	0.851	0.000
E24.1 Nelson's syndrome	0.149	0.851	0.000
E28 Ovarian dysfunction	0.144	0.856	0.000
E24.0 Pituitary-dependent Cushing's disease	0.142	0.858	0.000
E20.8 Other hypoparathyroidism	0.139	0.861	0.000
E20.1 Pseudohypoparathyroidism	0.139	0.861	0.000
E20.0 Idiopathic hypoparathyroidism	0.139	0.861	0.000
E25.9 Adrenogenital disorder, unspecified	0.136	0.864	0.000
E25.8 Other adrenogenital disorders	0.136	0.864	0.000
E34.9 Endocrine disorder, unspecified	0.135	0.865	0.000
E34.5 Androgen resistance syndrome	0.128	0.872	0.000
E34.4 Constitutional tall stature	0.128	0.872	0.000
E34.3 Short stature, not elsewhere classified	0.128	0.872	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.128	0.872	0.000
E34.1 Other hypersecretion of intestinal hormones	0.128	0.872	0.000
E20.9 Hypoparathyroidism, unspecified	0.125	0.875	0.000
E34.8 Other specified endocrine disorders	0.124	0.876	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.118	0.882	0.000
E24.9 Cushing's syndrome, unspecified	0.113	0.887	0.000
E28.9 Ovarian dysfunction, unspecified	0.103	0.896	0.000
E28.8 Other ovarian dysfunction	0.103	0.896	0.000
E28.1 Androgen excess	0.103	0.896	0.000
E28.0 Oestrogen excess	0.103	0.896	0.000
E28.3 Primary ovarian failure	0.102	0.897	0.000
E34.0 Carcinoid syndrome	0.095	0.905	0.000
K50 Crohn's disease [regional enteritis]	0.000	0.923	0.077
K50.1 Crohn's disease of large intestine	0.000	0.925	0.075
K50.8 Other Crohn's disease	0.000	0.925	0.075
K50.9 Crohn's disease, unspecified	0.000	0.926	0.074
K50.0 Crohn's disease of small intestine	0.000	0.938	0.062
E28.2 Polycystic ovarian syndrome	0.041	0.958	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.025	0.975	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.025	0.975	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.024	0.976	0.000
T43.2 Other and unspecified antidepressants	0.024	0.976	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.024	0.976	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.024	0.976	0.000
T39.1 4-Aminophenol derivatives	0.023	0.977	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.023	0.977	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.022	0.978	0.000
C92.1 Chronic myeloid leukaemia	0.000	0.979	0.021
T36 Poisoning by systemic antibiotics	0.021	0.979	0.000
T38.1 Thyroid hormones and substitutes	0.020	0.980	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.020	0.980	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.019	0.980	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.019	0.981	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.019	0.981	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.018	0.982	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.018	0.982	0.000
T42.0 Hydantoin derivatives	0.018	0.982	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.018	0.982	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.018	0.982	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.018	0.982	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.017	0.982	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.017	0.982	0.000
T42.3 Barbiturates	0.017	0.982	0.000
T42.2 Succinimides and oxazolidinediones	0.017	0.982	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.018	0.982	0.000
T39.4 Antirheumatics, not elsewhere classified	0.017	0.982	0.000
T39.2 Pyrazolone derivatives	0.017	0.982	0.000
T36.3 Macrolides	0.017	0.983	0.000
T38.9 Other and unspecified hormone antagonists	0.017	0.983	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.017	0.983	0.000
T38.7 Androgens and anabolic congeners	0.017	0.983	0.000
T38.5 Other oestrogens and progestogens	0.017	0.983	0.000
T38.4 Oral contraceptives	0.017	0.983	0.000
T38.2 Antithyroid drugs	0.017	0.983	0.000
T38.0 Glucocorticoids and synthetic analogues	0.017	0.983	0.000
T42.1 Iminostilbenes	0.017	0.983	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.017	0.983	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.017	0.983	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.017	0.983	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.017	0.983	0.000
T43.6 Psychostimulants with abuse potential	0.017	0.983	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.017	0.983	0.000
T43.9 Psychotropic drug, unspecified	0.016	0.983	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.016	0.983	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.016	0.983	0.000
T36.8 Other systemic antibiotics	0.016	0.984	0.000
Z34.8 Supervision of other normal pregnancy	0.016	0.984	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.016	0.984	0.000
T39.0 Salicylates	0.016	0.984	0.000
Z34 Supervision of normal pregnancy	0.016	0.984	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.015	0.985	0.000
T50.1 Loop [high-ceiling] diuretics	0.015	0.985	0.000
T42.4 Benzodiazepines	0.015	0.985	0.000
T40.4 Other synthetic narcotics	0.015	0.985	0.000
Z34.0 Supervision of normal first pregnancy	0.015	0.985	0.000
T36.9 Systemic antibiotic, unspecified	0.015	0.985	0.000
T36.7 Antifungal antibiotics, systemically used	0.015	0.985	0.000
T36.6 Rifamycins	0.015	0.985	0.000
T36.5 Aminoglycosides	0.015	0.985	0.000
T36.4 Tetracyclines	0.015	0.985	0.000
T36.2 Chloramphenicol group	0.015	0.985	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.015	0.985	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.015	0.985	0.000
Z34.9 Supervision of normal pregnancy, unspecified	0.015	0.985	0.000
T36.0 Penicillins	0.014	0.986	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.014	0.986	0.000
T48.4 Expectorants	0.014	0.986	0.000
T48.3 Antitussives	0.014	0.986	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.014	0.986	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.014	0.986	0.000
T48.0 Oxytocic drugs	0.014	0.986	0.000
T48.5 Anti-common-cold drugs	0.014	0.986	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.014	0.986	0.000
T50.8 Diagnostic agents	0.014	0.986	0.000
T50.7 Analeptics and opioid receptor antagonists	0.014	0.986	0.000
T50.5 Appetite depressants	0.014	0.986	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.014	0.986	0.000
T50.0 Mineralocorticoids and their antagonists	0.014	0.986	0.000
T47.6 Antidiarrhoeal drugs	0.014	0.986	0.000
C92 Myeloid leukaemia	0.000	0.986	0.014
T50.6 Antidotes and chelating agents, not elsewhere classified	0.014	0.986	0.000
T47.0 Histamine H(2)-receptor antagonists	0.013	0.986	0.000
T47.2 Stimulant laxatives	0.013	0.987	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.013	0.987	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.013	0.987	0.000
T47.7 Emetics	0.013	0.987	0.000
T47.5 Digestants	0.013	0.987	0.000
T47.4 Other laxatives	0.013	0.987	0.000
T47.3 Saline and osmotic laxatives	0.013	0.987	0.000
T41.5 Therapeutic gases	0.013	0.987	0.000
T41.4 Anaesthetic, unspecified	0.013	0.987	0.000
T41.3 Local anaesthetics	0.013	0.987	0.000
T41.2 Other and unspecified general anaesthetics	0.013	0.987	0.000
T41.1 Intravenous anaesthetics	0.013	0.987	0.000
T41.0 Inhaled anaesthetics	0.013	0.987	0.000
T49.9 Topical agent, unspecified	0.013	0.987	0.000
T49.8 Other topical agents	0.013	0.987	0.000
T49.7 Dental drugs, topically applied	0.013	0.987	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.013	0.987	0.000
T49.5 Ophthalmological drugs and preparations	0.013	0.987	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.013	0.987	0.000
T49.3 Emollients, demulcents and protectants	0.013	0.987	0.000
T49.2 Local astringents and local detergents	0.013	0.987	0.000
T49.1 Antipruritics	0.013	0.987	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.013	0.987	0.000
D17.6 Benign lipomatous neoplasm of spermatic cord	0.013	0.987	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.013	0.987	0.000
T40.8 Lysergide [LSD]	0.013	0.987	0.000
T40.7 Cannabis (derivatives)	0.013	0.987	0.000
T40.5 Cocaine	0.013	0.987	0.000
T40.3 Methadone	0.013	0.987	0.000
T40.1 Heroin	0.013	0.987	0.000
T40.0 Opium	0.013	0.987	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.013	0.987	0.000
Z63.4 Disappearance and death of family member	0.013	0.987	0.000
Z63 Other problems related to primary support group, including family circumstances	0.013	0.987	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.012	0.988	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.012	0.988	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.012	0.988	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.012	0.988	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.012	0.988	0.000
T44.0 Anticholinesterase agents	0.012	0.988	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.012	0.988	0.000
T37.5 Antiviral drugs	0.012	0.988	0.000
T37.4 Anthelminthics	0.012	0.988	0.000
T37.3 Other antiprotozoal drugs	0.012	0.988	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.012	0.988	0.000
T37.1 Antimycobacterial drugs	0.012	0.988	0.000
T37.0 Sulphonamides	0.012	0.988	0.000
I69.3 Sequelae of cerebral infarction	0.012	0.988	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.012	0.988	0.000
T50.4 Drugs affecting uric acid metabolism	0.012	0.988	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.012	0.988	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.012	0.988	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.012	0.988	0.000
Z63.7 Other stressful life events affecting family and household	0.012	0.988	0.000
T46.1 Calcium-channel blockers	0.011	0.988	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.011	0.988	0.000
C92.0 Acute myeloid leukaemia	0.000	0.989	0.011
T43.0 Tricyclic and tetracyclic antidepressants	0.011	0.989	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.011	0.989	0.000
C92.9 Myeloid leukaemia, unspecified	0.000	0.989	0.011
C92.4 Acute promyelocytic leukaemia	0.000	0.989	0.011
T46.3 Coronary vasodilators, not elsewhere classified	0.011	0.989	0.000
T40.6 Other and unspecified narcotics	0.011	0.989	0.000
Z63.0 Problems in relationship with spouse or partner	0.011	0.989	0.000
C92.7 Other myeloid leukaemia	0.000	0.989	0.010
Z63.6 Dependent relative needing care at home	0.010	0.989	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.010	0.989	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.010	0.989	0.000
T46.7 Peripheral vasodilators	0.010	0.989	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.010	0.989	0.000
Z63.5 Disruption of family by separation and divorce	0.010	0.990	0.000
T40.2 Other opioids	0.010	0.990	0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia	0.000	0.990	0.010
C92.6 Acute myeloid leukaemia with 11q23-abnormality	0.000	0.990	0.010
C92.5 Acute myelomonocytic leukaemia	0.000	0.990	0.010
C92.3 Myeloid sarcoma	0.000	0.990	0.010
C92.2 Subacute myeloid leukaemia	0.000	0.990	0.010
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.010	0.990	0.000
I69 Sequelae of cerebrovascular disease	0.010	0.990	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.010	0.990	0.000
I69.1 Sequelae of intracerebral haemorrhage	0.010	0.990	0.000
C44.3 Skin of other and unspecified parts of face	0.000	0.991	0.009
I61 Intracerebral haemorrhage	0.009	0.991	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.009	0.991	0.000
Z63.9 Problem related to primary support group, unspecified	0.009	0.991	0.000
Z63.3 Absence of family member	0.009	0.991	0.000
Z63.2 Inadequate family support	0.009	0.991	0.000
Z63.1 Problems in relationship with parents and in-laws	0.009	0.991	0.000
I61.0 Intracerebral haemorrhage in hemisphere, subcortical	0.009	0.991	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.009	0.991	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.008	0.991	0.000
I60 Subarachnoid haemorrhage	0.009	0.991	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.009	0.991	0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances	0.009	0.991	0.000
C71 Malignant neoplasm of brain	0.009	0.991	0.000
C71.9 Brain, unspecified	0.008	0.992	0.000
I61.1 Intracerebral haemorrhage in hemisphere, cortical	0.008	0.992	0.000
Z61 Problems related to negative life events in childhood	0.008	0.992	0.000
I69.8 Sequelae of other and unspecified cerebrovascular diseases	0.008	0.992	0.000
Z63.8 Other specified problems related to primary support group	0.008	0.992	0.000
K50-K52 Noninfective enteritis and colitis	0.000	0.992	0.008
I61.4 Intracerebral haemorrhage in cerebellum	0.008	0.992	0.000
Z56 Problems related to employment and unemployment	0.008	0.992	0.000
C71.8 Overlapping lesion of brain	0.008	0.992	0.000
I69.0 Sequelae of subarachnoid haemorrhage	0.008	0.992	0.000
I61.5 Intracerebral haemorrhage, intraventricular	0.008	0.992	0.000
T45.2 Vitamins, not elsewhere classified	0.007	0.992	0.000
I61.3 Intracerebral haemorrhage in brain stem	0.008	0.992	0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.007	0.992	0.000
T45.9 Primarily systemic and haematological agent, unspecified	0.007	0.992	0.000
T45.8 Other primarily systemic and haematological agents	0.007	0.992	0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.007	0.992	0.000
T45.6 Fibrinolysis-affecting drugs	0.007	0.992	0.000
T45.4 Iron and its compounds	0.007	0.992	0.000
T45.3 Enzymes, not elsewhere classified	0.007	0.992	0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery	0.008	0.992	0.000
I60-I69 Cerebrovascular diseases	0.008	0.992	0.000
Z61.4 Problems related to alleged sexual abuse of child by person within primary support group	0.007	0.992	0.000
C71.4 Occipital lobe	0.007	0.993	0.000
C71.3 Parietal lobe	0.007	0.993	0.000
N13.3 Other and unspecified hydronephrosis	0.000	0.993	0.007
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.007	0.993	0.000
C71.6 Cerebellum	0.007	0.993	0.000
E53.8 Deficiency of other specified B group vitamins	0.007	0.993	0.000
Z56.3 Stressful work schedule	0.007	0.993	0.000
G25.8 Other specified extrapyramidal and movement disorders	0.007	0.993	0.000
Z61.5 Problems related to alleged sexual abuse of child by person outside primary support group	0.007	0.993	0.000
Z58 Problems related to physical environment	0.007	0.993	0.000
C71.2 Temporal lobe	0.007	0.993	0.000
Z59 Problems related to housing and economic circumstances	0.007	0.993	0.000
I61.2 Intracerebral haemorrhage in hemisphere, unspecified	0.007	0.993	0.000
Z61.6 Problems related to alleged physical abuse of child	0.007	0.993	0.000
Y45.0 Opioids and related analgesics	0.007	0.993	0.000
I61.6 Intracerebral haemorrhage, multiple localised	0.007	0.993	0.000
T45.0 Antiallergic and antiemetic drugs	0.006	0.993	0.000
Z56.6 Other physical and mental strain related to work	0.006	0.993	0.000
Z59.1 Inadequate housing	0.006	0.993	0.000
I60.5 Subarachnoid haemorrhage from vertebral artery	0.006	0.994	0.000
Z62 Other problems related to upbringing	0.006	0.994	0.000
Z55 Problems related to education and literacy	0.006	0.994	0.000
C71.7 Brain stem	0.006	0.994	0.000
C71.5 Cerebral ventricle	0.006	0.994	0.000
Z65 Problems related to other psychosocial circumstances	0.006	0.994	0.000
I69.2 Sequelae of other nontraumatic intracranial haemorrhage	0.006	0.994	0.000
C71.0 Cerebrum, except lobes and ventricles	0.006	0.994	0.000
Z61.9 Negative life events in childhood, unspecified	0.006	0.994	0.000
Z61.8 Other negative life events in childhood	0.006	0.994	0.000
Z61.7 Personal frightening experience in childhood	0.006	0.994	0.000
Z61.3 Events resulting in loss of self-esteem in childhood	0.006	0.994	0.000
Z61.2 Altered pattern of family relationships in childhood	0.006	0.994	0.000
Z61.1 Removal from home in childhood	0.006	0.994	0.000
Z61.0 Loss of love relationship in childhood	0.006	0.994	0.000
I60.4 Subarachnoid haemorrhage from basilar artery	0.006	0.994	0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.006	0.994	0.000
G20 Parkinson's disease	0.006	0.994	0.000
T45.5 Anticoagulants	0.006	0.994	0.000
Z56.0 Unemployment, unspecified	0.006	0.994	0.000
G25 Other extrapyramidal and movement disorders	0.006	0.994	0.000
Y45.1 Salicylates	0.006	0.994	0.000
Z56.7 Other and unspecified problems related to employment	0.006	0.994	0.000
Z56.5 Uncongenial work	0.006	0.994	0.000
Z56.4 Discord with boss and workmates	0.006	0.994	0.000
Z56.2 Threat of job loss	0.006	0.994	0.000
Z56.1 Change of job	0.006	0.994	0.000
C71.1 Frontal lobe	0.006	0.994	0.000
Z60 Problems related to social environment	0.006	0.994	0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.006	0.994	0.000
R40.0 Somnolence	0.006	0.994	0.000
Z64 Problems related to certain psychosocial circumstances	0.006	0.994	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.006	0.994	0.000
G25.2 Other specified forms of tremor	0.005	0.994	0.000
I67.8 Other specified cerebrovascular diseases	0.006	0.994	0.000
I68 Cerebrovascular disorders in diseases classified elsewhere	0.005	0.994	0.000
D21.2 Connective and other soft tissue of lower limb, including hip	0.000	0.994	0.005
Z58.1 Exposure to air pollution	0.005	0.994	0.000
I60.8 Other subarachnoid haemorrhage	0.005	0.995	0.000
Z58.7 Exposure to tobacco smoke	0.005	0.995	0.000
Z60.8 Other problems related to social environment	0.005	0.995	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.005	0.995	0.001
Z59.0 Homelessness	0.005	0.995	0.000
Z58.5 Exposure to other pollution	0.005	0.995	0.000
E53 Deficiency of other B group vitamins	0.005	0.995	0.000
Z58.8 Other problems related to physical environment	0.005	0.995	0.000
Z58.9 Problem related to physical environment, unspecified	0.005	0.995	0.000
Z58.6 Inadequate drinking-water supply	0.005	0.995	0.000
Z58.4 Exposure to radiation	0.005	0.995	0.000
Z58.3 Exposure to soil pollution	0.005	0.995	0.000
Z58.2 Exposure to water pollution	0.005	0.995	0.000
Z58.0 Exposure to noise	0.005	0.995	0.000
Z59.7 Insufficient social insurance and welfare support	0.005	0.995	0.000
Z59.6 Low income	0.005	0.995	0.000
Z59.5 Extreme poverty	0.005	0.995	0.000
Z59.4 Lack of adequate food	0.005	0.995	0.000
Z59.3 Problems related to living in residential institution	0.005	0.995	0.000
Z59.2 Discord with neighbours, lodgers and landlord	0.005	0.995	0.000
I72.0 Aneurysm of carotid artery	0.005	0.995	0.000
G25.5 Other chorea	0.005	0.995	0.000
W06.0 Home	0.005	0.995	0.000
L98.8 Other specified disorders of skin and subcutaneous tissue	0.000	0.995	0.005
G20-G26 Extrapyramidal and movement disorders	0.005	0.995	0.000
I61.8 Other intracerebral haemorrhage	0.005	0.995	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.004	0.995	0.001
Z59.9 Problem relating to housing and economic circumstances, unspecified	0.005	0.995	0.000
I62 Other nontraumatic intracranial haemorrhage	0.005	0.995	0.000
G25.0 Essential tremor	0.005	0.995	0.000
I98.2 Oesophageal varices in diseases classified elsewhere	0.005	0.995	0.000
K14.9 Disease of tongue, unspecified	0.005	0.995	0.000
Z55.9 Problems relating to education and literacy, unspecified	0.005	0.995	0.000
Z55.8 Other problems relating to education and literacy	0.005	0.995	0.000
Z55.4 Educational maladjustment and discord with teachers and classmates	0.005	0.995	0.000
Z55.3 Underachievement in school	0.005	0.995	0.000
Z55.2 Failed examinations	0.005	0.995	0.000
Z55.1 Schooling unavailable and unattainable	0.005	0.995	0.000
Z55.0 Illiteracy and low-level literacy	0.005	0.995	0.000
Z62.9 Problem related to upbringing, unspecified	0.005	0.995	0.000
Z62.8 Other specified problems related to upbringing	0.005	0.995	0.000
Z62.6 Inappropriate parental pressure and other abnormal qualities of upbringing	0.005	0.995	0.000
Z62.5 Other problems related to neglect in upbringing	0.005	0.995	0.000
Z62.4 Emotional neglect of child	0.005	0.995	0.000
Z62.3 Hostility towards and scapegoating of child	0.005	0.995	0.000
Z62.2 Institutional upbringing	0.005	0.995	0.000
Z62.1 Parental overprotection	0.005	0.995	0.000
Z62.0 Inadequate parental supervision and control	0.005	0.995	0.000
Z65.9 Problem related to unspecified psychosocial circumstances	0.005	0.995	0.000
Z65.5 Exposure to disaster, war and other hostilities	0.005	0.995	0.000
Z65.4 Victim of crime and terrorism	0.005	0.995	0.000
Z65.3 Problems related to other legal circumstances	0.005	0.995	0.000
Z65.2 Problems related to release from prison	0.005	0.995	0.000
Z65.1 Imprisonment and other incarceration	0.005	0.995	0.000
Z65.0 Conviction in civil and criminal proceedings without imprisonment	0.005	0.995	0.000
I63 Cerebral infarction	0.005	0.995	0.000
Z65.8 Other specified problems related to psychosocial circumstances	0.005	0.995	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.005	0.995	0.000
I67 Other cerebrovascular diseases	0.005	0.995	0.000
I66.2 Occlusion and stenosis of posterior cerebral artery	0.005	0.995	0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.005	0.995	0.000
G25.1 Drug-induced tremor	0.005	0.995	0.000
G25.6 Drug-induced tics and other tics of organic origin	0.004	0.995	0.000
G25.4 Drug-induced chorea	0.004	0.995	0.000
I66.3 Occlusion and stenosis of cerebellar arteries	0.004	0.995	0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.005	0.995	0.000
Z60.5 Target of perceived adverse discrimination and persecution	0.004	0.996	0.000
Z60.4 Social exclusion and rejection	0.004	0.996	0.000
Z60.3 Acculturation difficulty	0.004	0.996	0.000
Z60.1 Atypical parenting situation	0.004	0.996	0.000
Z60.0 Problems of adjustment to life-cycle transitions	0.004	0.996	0.000
Y45.2 Propionic acid derivatives	0.004	0.996	0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.004	0.996	0.000
Z64.4 Discord with counsellors	0.004	0.996	0.000
Z64.3 Seeking and accepting behavioural and psychological interventions known to be hazardous and harmful	0.004	0.996	0.000
Z64.2 Seeking and accepting physical, nutritional and chemical interventions known to be hazardous and harmful	0.004	0.996	0.000
Z64.1 Problems related to multiparity	0.004	0.996	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.004	0.996	0.000
G25.9 Extrapyramidal and movement disorder, unspecified	0.004	0.996	0.000
I63.9 Cerebral infarction, unspecified	0.004	0.996	0.000
I66.8 Occlusion and stenosis of other cerebral artery	0.004	0.996	0.000
I66.1 Occlusion and stenosis of anterior cerebral artery	0.004	0.996	0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.004	0.996	0.000
M50.1 Cervical disk disorder with radiculopathy	0.004	0.996	0.000
I68.8 Other cerebrovascular disorders in diseases classified elsewhere	0.004	0.996	0.000
I68.2 Cerebral arteritis in other diseases classified elsewhere	0.004	0.996	0.000
I68.1 Cerebral arteritis in infectious and parasitic diseases classified elsewhere	0.004	0.996	0.000
M81.98 Osteoporosis, unspecified (Other)	0.004	0.996	0.000
F31.0 Bipolar affective disorder, current episode hypomanic	0.000	0.996	0.004
I66.9 Occlusion and stenosis of unspecified cerebral artery	0.004	0.996	0.000
Z60.9 Problem related to social environment, unspecified	0.004	0.996	0.000
G23 Other degenerative diseases of basal ganglia	0.004	0.996	0.000
E50-E64 Other nutritional deficiencies	0.004	0.996	0.000
I67.0 Dissection of cerebral arteries, nonruptured	0.004	0.996	0.000
G12.2 Motor neuron disease	0.004	0.996	0.000
E53.1 Pyridoxine deficiency	0.004	0.996	0.000
E53.0 Riboflavin deficiency	0.004	0.996	0.000
M77.91 Enthesopathy, unspecified (Shoulder region)	0.000	0.996	0.004
I68.0 Cerebral amyloid angiopathy	0.004	0.996	0.000
I62.9 Intracranial haemorrhage (nontraumatic), unspecified	0.004	0.996	0.000
I62.1 Nontraumatic extradural haemorrhage	0.004	0.996	0.000
O62.0 Primary inadequate contractions	0.004	0.996	0.000
G21 Secondary Parkinsonism	0.004	0.996	0.000
R57.2 Septic shock	0.000	0.996	0.004
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.004	0.996	0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere	0.004	0.996	0.000
G22 Parkinsonism in diseases classified elsewhere	0.004	0.996	0.000
I66.4 Occlusion and stenosis of multiple and bilateral cerebral arteries	0.004	0.996	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.004	0.996	0.000
K51.4 Pseudopolyposis of colon	0.000	0.996	0.004
I66.0 Occlusion and stenosis of middle cerebral artery	0.004	0.996	0.000
Z59.8 Other problems relating to housing and economic circumstances	0.003	0.996	0.000
I71 Aortic aneurysm and dissection	0.004	0.996	0.000
O62 Abnormalities of forces of labour	0.004	0.996	0.000
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.004	0.996	0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.004	0.996	0.000
E53.9 Vitamin B deficiency, unspecified	0.004	0.996	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.004	0.996	0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction	0.004	0.996	0.000
I67.7 Cerebral arteritis, not elsewhere classified	0.004	0.996	0.000
I67.6 Nonpyogenic thrombosis of intracranial venous system	0.004	0.996	0.000
I67.5 Moyamoya disease	0.004	0.996	0.000
I67.4 Hypertensive encephalopathy	0.004	0.996	0.000
I67.3 Progressive vascular leukoencephalopathy	0.004	0.996	0.000
O62.2 Other uterine inertia	0.004	0.996	0.000
Y45.4 Antirheumatics	0.004	0.996	0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]	0.003	0.996	0.000
H74.4 Polyp of middle ear	0.004	0.996	0.000
Z64.0 Problems related to unwanted pregnancy	0.003	0.996	0.000
I05.9 Mitral valve disease, unspecified	0.000	0.996	0.004
I63.8 Other cerebral infarction	0.004	0.996	0.000
I71.0 Dissection of aorta [any part]	0.004	0.996	0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.003	0.996	0.000
Y45.5 4-Aminophenol derivatives	0.003	0.997	0.000
M81.9 Osteoporosis, unspecified	0.003	0.997	0.000
G91.9 Hydrocephalus, unspecified	0.003	0.997	0.000
K51 Ulcerative colitis	0.000	0.997	0.003
G12 Spinal muscular atrophy and related syndromes	0.003	0.997	0.000
E58 Dietary calcium deficiency	0.003	0.997	0.000
O62.9 Abnormality of forces of labour, unspecified	0.003	0.997	0.000
O62.1 Secondary uterine inertia	0.003	0.997	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.003	0.997	0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.003	0.997	0.000
O62.4 Hypertonic, incoordinate and prolonged uterine contractions	0.003	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations