TreeWAS – Variant ID: rs3132569

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.001	0.999
M06 Other rheumatoid arthritis	0.996	0.004	0.000
M06.9 Rheumatoid arthritis, unspecified	0.996	0.004	0.000
M05-M14 Inflammatory polyarthropathies	0.996	0.004	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.995	0.005	0.000
M45 Ankylosing spondylitis	0.995	0.005	0.000
M05 Seropositive rheumatoid arthritis	0.993	0.007	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.991	0.009	0.000
M45-M49 Spondylopathies	0.991	0.009	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.986	0.014	0.000
L40.9 Psoriasis, unspecified	0.000	0.018	0.982
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.980	0.020	0.000
L40.5 Arthropathic psoriasis	0.000	0.021	0.979
L40 Psoriasis	0.000	0.022	0.978
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.973	0.027	0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.957	0.043	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.942	0.058	0.000
M06.3 Rheumatoid nodule	0.922	0.078	0.000
M86-M90 Other osteopathies	0.920	0.080	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.918	0.082	0.000
M89 Other disorders of bone	0.899	0.101	0.000
M47 Spondylosis	0.886	0.114	0.000
M89.0 Algoneurodystrophy	0.879	0.121	0.000
M47.9 Spondylosis, unspecified	0.875	0.125	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.869	0.131	0.000
E03 Other hypothyroidism	0.000	0.134	0.866
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.859	0.141	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.839	0.161	0.000
M06.34 Rheumatoid nodule (Hand)	0.838	0.162	0.000
M00-M03 Infectious arthropathies	0.825	0.175	0.000
M47.92 Spondylosis, unspecified (Cervical region)	0.822	0.178	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.819	0.181	0.000
M49 Spondylopathies in diseases classified elsewhere	0.818	0.182	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.808	0.192	0.000
M60-M63 Disorders of muscles	0.807	0.193	0.000
M12 Other specific arthropathies	0.803	0.197	0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)	0.798	0.202	0.000
M89.04 Algoneurodystrophy (Hand)	0.791	0.209	0.000
M45.X2 Ankylosing spondylitis (Cervical region)	0.787	0.213	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.780	0.220	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.779	0.221	0.000
M89.9 Disorder of bone, unspecified	0.777	0.223	0.000
L40.0 Psoriasis vulgaris	0.000	0.227	0.773
M89.06 Algoneurodystrophy (Lower leg)	0.767	0.232	0.000
M06.30 Rheumatoid nodule (Multiple sites)	0.761	0.239	0.000
E03.8 Other specified hypothyroidism	0.000	0.239	0.761
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.757	0.243	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.757	0.243	0.000
M05.8 Other seropositive rheumatoid arthritis	0.756	0.244	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.754	0.246	0.000
M47.96 Spondylosis, unspecified (Lumbar region)	0.751	0.249	0.000
M89.07 Algoneurodystrophy (Ankle and foot)	0.744	0.256	0.000
M47.98 Spondylosis, unspecified (Sacral and sacrococcygeal region)	0.736	0.264	0.000
E00-E07 Disorders of thyroid gland	0.000	0.280	0.720
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.718	0.282	0.000
M89.09 Algoneurodystrophy (Site unspecified)	0.717	0.283	0.000
M06.8 Other specified rheumatoid arthritis	0.714	0.286	0.000
M06.2 Rheumatoid bursitis	0.714	0.286	0.000
M06.1 Adult-onset Still's disease	0.714	0.286	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.714	0.286	0.000
M08 Juvenile arthritis	0.714	0.286	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.713	0.287	0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.713	0.287	0.000
M45.X6 Ankylosing spondylitis (Lumbar region)	0.713	0.287	0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.713	0.287	0.000
M45.X4 Ankylosing spondylitis (Thoracic region)	0.713	0.287	0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.713	0.287	0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.713	0.287	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.712	0.288	0.000
M05.2 Rheumatoid vasculitis	0.712	0.288	0.000
M05.1 Rheumatoid lung disease	0.712	0.288	0.000
M05.0 Felty's syndrome	0.712	0.288	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.711	0.289	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.711	0.289	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.711	0.289	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.711	0.289	0.000
M40-M43 Deforming dorsopathies	0.710	0.290	0.000
M06.4 Inflammatory polyarthropathy	0.705	0.295	0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)	0.704	0.296	0.000
L40.4 Guttate psoriasis	0.000	0.298	0.701
L40.2 Acrodermatitis continua	0.000	0.298	0.701
L40.1 Generalised pustular psoriasis	0.000	0.298	0.701
M80-M85 Disorders of bone density and structure	0.701	0.299	0.000
M00 Pyogenic arthritis	0.696	0.304	0.000
M49.5 Collapsed vertebra in diseases classified elsewhere	0.695	0.305	0.000
M87 Osteonecrosis	0.680	0.320	0.000
M89.5 Osteolysis	0.676	0.324	0.000
M62 Other disorders of muscle	0.670	0.330	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.661	0.339	0.000
M06.38 Rheumatoid nodule (Other)	0.661	0.339	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.661	0.339	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.661	0.339	0.000
M06.33 Rheumatoid nodule (Forearm)	0.661	0.339	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.661	0.339	0.000
E06 Thyroiditis	0.000	0.343	0.657
E07 Other disorders of thyroid	0.000	0.344	0.656
M89.6 Osteopathy after poliomyelitis	0.645	0.355	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.645	0.355	0.000
M89.2 Other disorders of bone development and growth	0.645	0.355	0.000
M89.1 Epiphyseal arrest	0.645	0.355	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.639	0.360	0.000
M12.3 Palindromic rheumatism	0.638	0.362	0.000
M14 Arthropathies in other diseases classified elsewhere	0.636	0.364	0.000
M47.0 Anterior spinal and vertebral artery compression syndromes	0.635	0.364	0.000
M89.91 Disorder of bone, unspecified (Shoulder region)	0.631	0.369	0.000
M89.08 Algoneurodystrophy (Other)	0.630	0.370	0.000
M89.05 Algoneurodystrophy (Pelvic region and thigh)	0.630	0.370	0.000
M89.02 Algoneurodystrophy (Upper arm)	0.630	0.370	0.000
M89.01 Algoneurodystrophy (Shoulder region)	0.630	0.370	0.000
M89.00 Algoneurodystrophy (Multiple sites)	0.630	0.370	0.000
M47.95 Spondylosis, unspecified (Thoracolumbar region)	0.627	0.373	0.000
M47.93 Spondylosis, unspecified (Cervicothoracic region)	0.627	0.373	0.000
M47.91 Spondylosis, unspecified (Occipito-atlanto-axial region)	0.627	0.373	0.000
M41 Scoliosis	0.625	0.375	0.000
E03.5 Myxoedema coma	0.000	0.379	0.621
E03.4 Atrophy of thyroid (acquired)	0.000	0.379	0.621
E03.3 Postinfectious hypothyroidism	0.000	0.379	0.621
M89.03 Algoneurodystrophy (Forearm)	0.621	0.379	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.382	0.618
M06.0 Seronegative rheumatoid arthritis	0.617	0.383	0.000
M02 Reactive arthropathies	0.616	0.384	0.000
M12.2 Villonodular synovitis (pigmented)	0.614	0.386	0.000
L40.3 Pustulosis palmaris et plantaris	0.000	0.386	0.613
M11 Other crystal arthropathies	0.611	0.388	0.000
M47.1 Other spondylosis with myelopathy	0.611	0.389	0.000
E06.3 Autoimmune thyroiditis	0.000	0.391	0.609
M49.54 Collapsed vertebra in diseases classified elsewhere (Thoracic region)	0.607	0.393	0.000
M13 Other arthritis	0.605	0.395	0.000
M00.9 Pyogenic arthritis, unspecified	0.604	0.396	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.597	0.403	0.000
M47.94 Spondylosis, unspecified (Thoracic region)	0.597	0.403	0.000
M48 Other spondylopathies	0.595	0.405	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.406	0.594
M60 Myositis	0.593	0.406	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.591	0.408	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.591	0.408	0.000
M89.3 Hypertrophy of bone	0.589	0.410	0.000
E07.9 Disorder of thyroid, unspecified	0.000	0.411	0.589
M49.8 Spondylopathy in other diseases classified elsewhere	0.587	0.413	0.000
M49.4 Neuropathic spondylopathy	0.587	0.413	0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.587	0.413	0.000
M49.2 Enterobacterial spondylitis	0.587	0.413	0.000
M49.1 Brucella spondylitis	0.587	0.413	0.000
M49.0 Tuberculosis of spine	0.587	0.413	0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.586	0.414	0.000
M47.99 Spondylosis, unspecified (Site unspecified)	0.579	0.421	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.579	0.421	0.000
M61 Calcification and ossification of muscle	0.579	0.421	0.000
M88 Paget's disease of bone [osteitis deformans]	0.578	0.422	0.000
M89.94 Disorder of bone, unspecified (Hand)	0.578	0.422	0.000
M91-M94 Chondropathies	0.577	0.423	0.000
M86 Osteomyelitis	0.576	0.424	0.000
M12.8 Other specific arthropathies, not elsewhere classified	0.576	0.424	0.000
M12.5 Traumatic arthropathy	0.576	0.424	0.000
M12.4 Intermittent hydrarthrosis	0.576	0.424	0.000
M12.1 Kaschin-Beck disease	0.576	0.424	0.000
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.576	0.424	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.433	0.567
E03.1 Congenital hypothyroidism without goitre	0.000	0.438	0.562
M89.98 Disorder of bone, unspecified (Other)	0.560	0.440	0.000
M89.99 Disorder of bone, unspecified (Site unspecified)	0.557	0.443	0.000
M89.93 Disorder of bone, unspecified (Forearm)	0.557	0.443	0.000
M89.92 Disorder of bone, unspecified (Upper arm)	0.557	0.443	0.000
M89.90 Disorder of bone, unspecified (Multiple sites)	0.557	0.443	0.000
M90 Osteopathies in diseases classified elsewhere	0.557	0.443	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.555	0.445	0.000
M41.9 Scoliosis, unspecified	0.554	0.446	0.000
M82 Osteoporosis in diseases classified elsewhere	0.552	0.448	0.000
L40.8 Other psoriasis	0.000	0.450	0.550
M85 Other disorders of bone density and structure	0.545	0.455	0.000
M65-M68 Disorders of synovium and tendon	0.545	0.455	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.543	0.457	0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.542	0.458	0.000
M05.88 Other seropositive rheumatoid arthritis (Other)	0.542	0.458	0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.542	0.458	0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.542	0.458	0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.542	0.458	0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.542	0.458	0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.542	0.458	0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.542	0.458	0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.542	0.458	0.000
M84 Disorders of continuity of bone	0.539	0.461	0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)	0.539	0.461	0.000
M00.96 Pyogenic arthritis, unspecified (Lower leg)	0.536	0.464	0.000
M83 Adult osteomalacia	0.533	0.467	0.000
E07.8 Other specified disorders of thyroid	0.000	0.471	0.529
M89.8 Other specified disorders of bone	0.526	0.473	0.000
M87.8 Other osteonecrosis	0.525	0.475	0.000
M62.8 Other specified disorders of muscle	0.524	0.476	0.000
M12.39 Palindromic rheumatism (Site unspecified)	0.520	0.480	0.000
M89.55 Osteolysis (Pelvic region and thigh)	0.517	0.483	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.483	0.516
E00 Congenital iodine-deficiency syndrome	0.000	0.483	0.516
M13.1 Monoarthritis, not elsewhere classified	0.513	0.487	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.512	0.488	0.000
M06.18 Adult-onset Still's disease (Other)	0.512	0.488	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.512	0.488	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.512	0.488	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.512	0.488	0.000
M06.14 Adult-onset Still's disease (Hand)	0.512	0.488	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.512	0.488	0.000
M06.12 Adult-onset Still's disease (Upper arm)	0.512	0.488	0.000
M06.11 Adult-onset Still's disease (Shoulder region)	0.512	0.488	0.000
M06.10 Adult-onset Still's disease (Multiple sites)	0.512	0.488	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.512	0.488	0.000
M06.28 Rheumatoid bursitis (Other)	0.512	0.488	0.000
M06.27 Rheumatoid bursitis (Ankle and foot)	0.512	0.488	0.000
M06.26 Rheumatoid bursitis (Lower leg)	0.512	0.488	0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.512	0.488	0.000
M06.24 Rheumatoid bursitis (Hand)	0.512	0.488	0.000
M06.23 Rheumatoid bursitis (Forearm)	0.512	0.488	0.000
M06.22 Rheumatoid bursitis (Upper arm)	0.512	0.488	0.000
M06.21 Rheumatoid bursitis (Shoulder region)	0.512	0.488	0.000
M06.20 Rheumatoid bursitis (Multiple sites)	0.512	0.488	0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.512	0.488	0.000
M06.88 Other specified rheumatoid arthritis (Other)	0.512	0.488	0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.512	0.488	0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.512	0.488	0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.512	0.488	0.000
M06.84 Other specified rheumatoid arthritis (Hand)	0.512	0.488	0.000
M06.83 Other specified rheumatoid arthritis (Forearm)	0.512	0.488	0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.512	0.488	0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.512	0.488	0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.512	0.488	0.000
M08.9 Juvenile arthritis, unspecified	0.512	0.488	0.000
M08.8 Other juvenile arthritis	0.512	0.488	0.000
M08.4 Pauciarticular juvenile arthritis	0.512	0.488	0.000
M08.3 Juvenile polyarthritis (seronegative)	0.512	0.488	0.000
M08.2 Juvenile arthritis with systemic onset	0.512	0.488	0.000
M08.1 Juvenile ankylosing spondylitis	0.512	0.488	0.000
M08.0 Juvenile rheumatoid arthritis	0.512	0.488	0.000
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.512	0.488	0.000
M09.2 Juvenile arthritis in ulcerative colitis	0.512	0.488	0.000
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.512	0.488	0.000
M09.0 Juvenile arthritis in psoriasis	0.512	0.488	0.000
M05.09 Felty's syndrome (Site unspecified)	0.511	0.489	0.000
M05.08 Felty's syndrome (Other)	0.511	0.489	0.000
M05.07 Felty's syndrome (Ankle and foot)	0.511	0.489	0.000
M05.06 Felty's syndrome (Lower leg)	0.511	0.489	0.000
M05.05 Felty's syndrome (Pelvic region and thigh)	0.511	0.489	0.000
M05.04 Felty's syndrome (Hand)	0.511	0.489	0.000
M05.03 Felty's syndrome (Forearm)	0.511	0.489	0.000
M05.02 Felty's syndrome (Upper arm)	0.511	0.489	0.000
M05.01 Felty's syndrome (Shoulder region)	0.511	0.489	0.000
M05.00 Felty's syndrome (Multiple sites)	0.511	0.489	0.000
M05.19 Rheumatoid lung disease (Site unspecified)	0.511	0.489	0.000
M05.18 Rheumatoid lung disease (Other)	0.511	0.489	0.000
M05.17 Rheumatoid lung disease (Ankle and foot)	0.511	0.489	0.000
M05.16 Rheumatoid lung disease (Lower leg)	0.511	0.489	0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.511	0.489	0.000
M05.14 Rheumatoid lung disease (Hand)	0.511	0.489	0.000
M05.13 Rheumatoid lung disease (Forearm)	0.511	0.489	0.000
M05.12 Rheumatoid lung disease (Upper arm)	0.511	0.489	0.000
M05.11 Rheumatoid lung disease (Shoulder region)	0.511	0.489	0.000
M05.10 Rheumatoid lung disease (Multiple sites)	0.511	0.489	0.000
M05.29 Rheumatoid vasculitis (Site unspecified)	0.511	0.489	0.000
M05.28 Rheumatoid vasculitis (Other)	0.511	0.489	0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.511	0.489	0.000
M05.26 Rheumatoid vasculitis (Lower leg)	0.511	0.489	0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.511	0.489	0.000
M05.24 Rheumatoid vasculitis (Hand)	0.511	0.489	0.000
M05.23 Rheumatoid vasculitis (Forearm)	0.511	0.489	0.000
M05.22 Rheumatoid vasculitis (Upper arm)	0.511	0.489	0.000
M05.21 Rheumatoid vasculitis (Shoulder region)	0.511	0.489	0.000
M05.20 Rheumatoid vasculitis (Multiple sites)	0.511	0.489	0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.511	0.489	0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.511	0.489	0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.511	0.489	0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.511	0.489	0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.511	0.489	0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.511	0.489	0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.511	0.489	0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.511	0.489	0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.511	0.489	0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.511	0.489	0.000
M50-M54 Other dorsopathies	0.510	0.490	0.000
M42 Spinal osteochondrosis	0.509	0.491	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.505	0.494	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.505	0.494	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.505	0.494	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.505	0.494	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.505	0.494	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.505	0.494	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.505	0.494	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.505	0.494	0.000
M89.96 Disorder of bone, unspecified (Lower leg)	0.505	0.495	0.000
M48.9 Spondylopathy, unspecified	0.505	0.495	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.504	0.496	0.000
E05.9 Thyrotoxicosis, unspecified	0.000	0.497	0.503
M87.9 Osteonecrosis, unspecified	0.500	0.500	0.000
M00.8 Arthritis and polyarthritis due to other specified bacterial agents	0.499	0.501	0.000
M00.2 Other streptococcal arthritis and polyarthritis	0.499	0.501	0.000
M00.1 Pneumococcal arthritis and polyarthritis	0.499	0.501	0.000
M00.0 Staphylococcal arthritis and polyarthritis	0.499	0.501	0.000
M46 Other inflammatory spondylopathies	0.499	0.501	0.000
M49.59 Collapsed vertebra in diseases classified elsewhere (Site unspecified)	0.498	0.502	0.000
M49.58 Collapsed vertebra in diseases classified elsewhere (Sacral and sacrococcygeal region)	0.498	0.502	0.000
M49.57 Collapsed vertebra in diseases classified elsewhere (Lumbosacral region)	0.498	0.502	0.000
M49.55 Collapsed vertebra in diseases classified elsewhere (Thoracolumbar region)	0.498	0.502	0.000
M49.53 Collapsed vertebra in diseases classified elsewhere (Cervicothoracic region)	0.498	0.502	0.000
M49.52 Collapsed vertebra in diseases classified elsewhere (Cervical region)	0.498	0.502	0.000
M49.51 Collapsed vertebra in diseases classified elsewhere (Occipito-atlanto-axial region)	0.498	0.502	0.000
M49.50 Collapsed vertebra in diseases classified elsewhere (Multiple sites in spine)	0.498	0.502	0.000
M49.56 Collapsed vertebra in diseases classified elsewhere (Lumbar region)	0.496	0.504	0.000
M12.24 Villonodular synovitis (pigmented) (Hand)	0.496	0.504	0.000
M62.9 Disorder of muscle, unspecified	0.494	0.505	0.000
M62.6 Muscle strain	0.492	0.508	0.000
M87.3 Other secondary osteonecrosis	0.488	0.512	0.000
M87.1 Osteonecrosis due to drugs	0.488	0.512	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.488	0.512	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.513	0.487
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.486	0.514	0.000
M89.59 Osteolysis (Site unspecified)	0.485	0.515	0.000
M89.58 Osteolysis (Other)	0.485	0.515	0.000
M89.57 Osteolysis (Ankle and foot)	0.485	0.515	0.000
M89.56 Osteolysis (Lower leg)	0.485	0.515	0.000
M89.54 Osteolysis (Hand)	0.485	0.515	0.000
M89.53 Osteolysis (Forearm)	0.485	0.515	0.000
M89.52 Osteolysis (Upper arm)	0.485	0.515	0.000
M89.51 Osteolysis (Shoulder region)	0.485	0.515	0.000
M89.50 Osteolysis (Multiple sites)	0.485	0.515	0.000
E06.9 Thyroiditis, unspecified	0.000	0.519	0.481
M13.8 Other specified arthritis	0.481	0.519	0.000
M62.4 Contracture of muscle	0.480	0.519	0.000
M62.3 Immobility syndrome (paraplegic)	0.480	0.519	0.000
M62.2 Ischaemic infarction of muscle	0.480	0.519	0.000
M62.0 Diastasis of muscle	0.480	0.519	0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)	0.480	0.520	0.000
M85.8 Other specified disorders of bone density and structure	0.478	0.522	0.000
M81 Osteoporosis without pathological fracture	0.476	0.524	0.000
M41.8 Other forms of scoliosis	0.475	0.525	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.525	0.475
M07 Psoriatic and enteropathic arthropathies	0.470	0.526	0.005
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.473	0.526	0.000
M53 Other dorsopathies, not elsewhere classified	0.473	0.527	0.000
M48.8 Other specified spondylopathies	0.473	0.527	0.000
E06.5 Other chronic thyroiditis	0.000	0.529	0.471
E06.4 Drug-induced thyroiditis	0.000	0.529	0.471
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.529	0.471
E06.1 Subacute thyroiditis	0.000	0.529	0.471
E06.0 Acute thyroiditis	0.000	0.529	0.471
M10 Gout	0.471	0.529	0.000
E07.1 Dyshormogenetic goitre	0.000	0.530	0.470
E07.0 Hypersecretion of calcitonin	0.000	0.530	0.470
M60.0 Infective myositis	0.470	0.530	0.000
M89.38 Hypertrophy of bone (Other)	0.469	0.530	0.000
M40 Kyphosis and lordosis	0.467	0.533	0.000
K90 Intestinal malabsorption	0.000	0.535	0.465
M86.1 Other acute osteomyelitis	0.464	0.536	0.000
M02.3 Reiter's disease	0.463	0.537	0.000
M89.19 Epiphyseal arrest (Site unspecified)	0.462	0.538	0.000
M89.18 Epiphyseal arrest (Other)	0.462	0.538	0.000
M89.17 Epiphyseal arrest (Ankle and foot)	0.462	0.538	0.000
M89.16 Epiphyseal arrest (Lower leg)	0.462	0.538	0.000
M89.15 Epiphyseal arrest (Pelvic region and thigh)	0.462	0.538	0.000
M89.14 Epiphyseal arrest (Hand)	0.462	0.538	0.000
M89.13 Epiphyseal arrest (Forearm)	0.462	0.538	0.000
M89.12 Epiphyseal arrest (Upper arm)	0.462	0.538	0.000
M89.11 Epiphyseal arrest (Shoulder region)	0.462	0.538	0.000
M89.10 Epiphyseal arrest (Multiple sites)	0.462	0.538	0.000
M89.29 Other disorders of bone development and growth (Site unspecified)	0.462	0.538	0.000
M89.28 Other disorders of bone development and growth (Other)	0.462	0.538	0.000
M89.27 Other disorders of bone development and growth (Ankle and foot)	0.462	0.538	0.000
M89.26 Other disorders of bone development and growth (Lower leg)	0.462	0.538	0.000
M89.25 Other disorders of bone development and growth (Pelvic region and thigh)	0.462	0.538	0.000
M89.24 Other disorders of bone development and growth (Hand)	0.462	0.538	0.000
M89.23 Other disorders of bone development and growth (Forearm)	0.462	0.538	0.000
M89.22 Other disorders of bone development and growth (Upper arm)	0.462	0.538	0.000
M89.21 Other disorders of bone development and growth (Shoulder region)	0.462	0.538	0.000
M89.20 Other disorders of bone development and growth (Multiple sites)	0.462	0.538	0.000
M89.49 Other hypertrophic osteoarthropathy (Site unspecified)	0.462	0.538	0.000
M89.48 Other hypertrophic osteoarthropathy (Other)	0.462	0.538	0.000
M89.47 Other hypertrophic osteoarthropathy (Ankle and foot)	0.462	0.538	0.000
M89.46 Other hypertrophic osteoarthropathy (Lower leg)	0.462	0.538	0.000
M89.45 Other hypertrophic osteoarthropathy (Pelvic region and thigh)	0.462	0.538	0.000
M89.44 Other hypertrophic osteoarthropathy (Hand)	0.462	0.538	0.000
M89.43 Other hypertrophic osteoarthropathy (Forearm)	0.462	0.538	0.000
M89.42 Other hypertrophic osteoarthropathy (Upper arm)	0.462	0.538	0.000
M89.41 Other hypertrophic osteoarthropathy (Shoulder region)	0.462	0.538	0.000
M89.40 Other hypertrophic osteoarthropathy (Multiple sites)	0.462	0.538	0.000
M89.69 Osteopathy after poliomyelitis (Site unspecified)	0.462	0.538	0.000
M89.68 Osteopathy after poliomyelitis (Other)	0.462	0.538	0.000
M89.67 Osteopathy after poliomyelitis (Ankle and foot)	0.462	0.538	0.000
M89.66 Osteopathy after poliomyelitis (Lower leg)	0.462	0.538	0.000
M89.65 Osteopathy after poliomyelitis (Pelvic region and thigh)	0.462	0.538	0.000
M89.64 Osteopathy after poliomyelitis (Hand)	0.462	0.538	0.000
M89.63 Osteopathy after poliomyelitis (Forearm)	0.462	0.538	0.000
M89.62 Osteopathy after poliomyelitis (Upper arm)	0.462	0.538	0.000
M89.61 Osteopathy after poliomyelitis (Shoulder region)	0.462	0.538	0.000
M89.60 Osteopathy after poliomyelitis (Multiple sites)	0.462	0.538	0.000
M41.94 Scoliosis, unspecified (Thoracic region)	0.461	0.539	0.000
M12.38 Palindromic rheumatism (Other)	0.458	0.542	0.000
M12.37 Palindromic rheumatism (Ankle and foot)	0.458	0.542	0.000
M12.36 Palindromic rheumatism (Lower leg)	0.458	0.542	0.000
M12.35 Palindromic rheumatism (Pelvic region and thigh)	0.458	0.542	0.000
M12.34 Palindromic rheumatism (Hand)	0.458	0.542	0.000
M12.33 Palindromic rheumatism (Forearm)	0.458	0.542	0.000
M12.32 Palindromic rheumatism (Upper arm)	0.458	0.542	0.000
M12.31 Palindromic rheumatism (Shoulder region)	0.458	0.542	0.000
M12.30 Palindromic rheumatism (Multiple sites)	0.458	0.542	0.000
M00.92 Pyogenic arthritis, unspecified (Upper arm)	0.458	0.542	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.456	0.544	0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.456	0.544	0.000
M14.4 Arthropathy in amyloidosis	0.456	0.544	0.000
M14.3 Lipoid dermatoarthritis	0.456	0.544	0.000
M14.2 Diabetic arthropathy	0.456	0.544	0.000
M14.1 Crystal arthropathy in other metabolic disorders	0.456	0.544	0.000
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.456	0.544	0.000
M47.09 Anterior spinal and vertebral artery compression syndromes (Site unspecified)	0.456	0.544	0.000
M47.08 Anterior spinal and vertebral artery compression syndromes (Sacral and sacrococcygeal region)	0.456	0.544	0.000
M47.07 Anterior spinal and vertebral artery compression syndromes (Lumbosacral region)	0.456	0.544	0.000
M47.06 Anterior spinal and vertebral artery compression syndromes (Lumbar region)	0.456	0.544	0.000
M47.05 Anterior spinal and vertebral artery compression syndromes (Thoracolumbar region)	0.456	0.544	0.000
M47.04 Anterior spinal and vertebral artery compression syndromes (Thoracic region)	0.456	0.544	0.000
M47.03 Anterior spinal and vertebral artery compression syndromes (Cervicothoracic region)	0.456	0.544	0.000
M47.02 Anterior spinal and vertebral artery compression syndromes (Cervical region)	0.456	0.544	0.000
M47.01 Anterior spinal and vertebral artery compression syndromes (Occipito-atlanto-axial region)	0.456	0.544	0.000
M47.00 Anterior spinal and vertebral artery compression syndromes (Multiple sites in spine)	0.456	0.544	0.000
M47.2 Other spondylosis with radiculopathy	0.456	0.544	0.000
M00.90 Pyogenic arthritis, unspecified (Multiple sites)	0.453	0.547	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.452	0.548	0.000
M87.2 Osteonecrosis due to previous trauma	0.452	0.548	0.000
M62.11 Other rupture of muscle (nontraumatic) (Shoulder region)	0.452	0.548	0.000
M70-M79 Other soft tissue disorders	0.451	0.549	0.000
M41.5 Other secondary scoliosis	0.448	0.551	0.000
M41.4 Neuromuscular scoliosis	0.448	0.551	0.000
M41.3 Thoracogenic scoliosis	0.448	0.551	0.000
M41.2 Other idiopathic scoliosis	0.448	0.551	0.000
M41.1 Juvenile idiopathic scoliosis	0.448	0.551	0.000
M41.0 Infantile idiopathic scoliosis	0.448	0.551	0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.448	0.552	0.000
M00.94 Pyogenic arthritis, unspecified (Hand)	0.447	0.553	0.000
M13.16 Monoarthritis, not elsewhere classified (Lower leg)	0.447	0.553	0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.446	0.554	0.000
M82.1 Osteoporosis in endocrine disorders	0.446	0.554	0.000
M02.9 Reactive arthopathy, unspecified	0.444	0.555	0.000
M65 Synovitis and tenosynovitis	0.444	0.556	0.000
M06.08 Seronegative rheumatoid arthritis (Other)	0.442	0.557	0.000
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.442	0.557	0.000
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.442	0.557	0.000
M06.04 Seronegative rheumatoid arthritis (Hand)	0.442	0.557	0.000
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.442	0.557	0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.442	0.557	0.000
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.442	0.557	0.000
M02.8 Other reactive arthropathies	0.441	0.558	0.000
M02.2 Postimmunisation arthropathy	0.441	0.558	0.000
M02.1 Postdysenteric arthropathy	0.441	0.558	0.000
M02.0 Arthropathy following intestinal bypass	0.441	0.558	0.000
M12.29 Villonodular synovitis (pigmented) (Site unspecified)	0.440	0.560	0.000
M12.28 Villonodular synovitis (pigmented) (Other)	0.440	0.560	0.000
M12.27 Villonodular synovitis (pigmented) (Ankle and foot)	0.440	0.560	0.000
M12.25 Villonodular synovitis (pigmented) (Pelvic region and thigh)	0.440	0.560	0.000
M12.23 Villonodular synovitis (pigmented) (Forearm)	0.440	0.560	0.000
M12.22 Villonodular synovitis (pigmented) (Upper arm)	0.440	0.560	0.000
M12.21 Villonodular synovitis (pigmented) (Shoulder region)	0.440	0.560	0.000
M12.20 Villonodular synovitis (pigmented) (Multiple sites)	0.440	0.560	0.000
M11.9 Crystal arthropathy, unspecified	0.438	0.561	0.000
M11.8 Other specified crystal arthropathies	0.438	0.561	0.000
M11.1 Familial chondrocalcinosis	0.438	0.561	0.000
M11.0 Hydroxyapatite deposition disease	0.438	0.561	0.000
M47.19 Other spondylosis with myelopathy (Site unspecified)	0.438	0.562	0.000
M47.18 Other spondylosis with myelopathy (Sacral and sacrococcygeal region)	0.438	0.562	0.000
M47.17 Other spondylosis with myelopathy (Lumbosacral region)	0.438	0.562	0.000
M47.16 Other spondylosis with myelopathy (Lumbar region)	0.438	0.562	0.000
M47.15 Other spondylosis with myelopathy (Thoracolumbar region)	0.438	0.562	0.000
M47.14 Other spondylosis with myelopathy (Thoracic region)	0.438	0.562	0.000
M47.13 Other spondylosis with myelopathy (Cervicothoracic region)	0.438	0.562	0.000
M47.11 Other spondylosis with myelopathy (Occipito-atlanto-axial region)	0.438	0.562	0.000
M47.10 Other spondylosis with myelopathy (Multiple sites in spine)	0.438	0.562	0.000
M00.99 Pyogenic arthritis, unspecified (Site unspecified)	0.433	0.567	0.000
M00.98 Pyogenic arthritis, unspecified (Other)	0.433	0.567	0.000
M00.97 Pyogenic arthritis, unspecified (Ankle and foot)	0.433	0.567	0.000
M00.95 Pyogenic arthritis, unspecified (Pelvic region and thigh)	0.433	0.567	0.000
M00.93 Pyogenic arthritis, unspecified (Forearm)	0.433	0.567	0.000
M53.38 Sacrococcygeal disorders, not elsewhere classified-Sacral/s	0.430	0.570	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.427	0.572	0.000
M48.4 Fatigue fracture of vertebra	0.427	0.573	0.000
M48.3 Traumatic spondylopathy	0.427	0.573	0.000
M48.2 Kissing spine	0.427	0.573	0.000
M48.1 Ankylosing hyperostosis [Forestier]	0.427	0.573	0.000
M87.86 Other osteonecrosis (Lower leg)	0.426	0.574	0.000
M89.85 Other specified disorders of bone (Pelvic region and thigh)	0.426	0.574	0.000
E05.5 Thyroid crisis or storm	0.000	0.574	0.426
E05.4 Thyrotoxicosis factitia	0.000	0.574	0.426
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.574	0.426
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.574	0.426
M60.8 Other myositis	0.426	0.574	0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified	0.426	0.574	0.000
M60.1 Interstitial myositis	0.426	0.574	0.000
M41.96 Scoliosis, unspecified (Lumbar region)	0.425	0.575	0.000
M84.3 Stress fracture, not elsewhere classified	0.425	0.575	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.425	0.575	0.000
M01.8 Arthritis in other infectious and parasitic diseases classified elsewhere	0.424	0.576	0.000
M01.6 Arthritis in mycoses	0.424	0.576	0.000
M01.5 Arthritis in other viral diseases classified elsewhere	0.424	0.576	0.000
M01.4 Rubella arthritis	0.424	0.576	0.000
M01.3 Arthritis in other bacterial diseases classified elsewhere	0.424	0.576	0.000
M01.2 Arthritis in Lyme disease	0.424	0.576	0.000
M01.1 Tuberculous arthritis	0.424	0.576	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations