TreeWAS – Variant ID: rs3755652

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I10 Essential (primary) hypertension	1.000	0.000	0.000
I10-I15 Hypertensive diseases	0.193	0.807	0.000
I13 Hypertensive heart and renal disease	0.138	0.861	0.000
I11 Hypertensive heart disease	0.125	0.875	0.000
I15 Secondary hypertension	0.120	0.880	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.099	0.900	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.099	0.900	0.000
I13.1 Hypertensive heart and renal disease with renal failure	0.099	0.900	0.000
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.099	0.900	0.000
I12 Hypertensive renal disease	0.095	0.905	0.000
I15.0 Renovascular hypertension	0.093	0.907	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.090	0.909	0.000
I15.8 Other secondary hypertension	0.086	0.913	0.000
I15.2 Hypertension secondary to endocrine disorders	0.086	0.913	0.000
I15.1 Hypertension secondary to other renal disorders	0.083	0.917	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.074	0.926	0.000
I15.9 Seconday hypertension, unspecified	0.062	0.938	0.000
I12.0 Hypertensive renal disease with renal failure	0.052	0.948	0.000
I12.9 Hypertensive renal disease without renal failure	0.051	0.949	0.000
E23.0 Hypopituitarism	0.030	0.970	0.000
E23 Hypofunction and other disorders of pituitary gland	0.029	0.971	0.000
E20-E35 Disorders of other endocrine glands	0.027	0.973	0.000
C91.1 Chronic lymphocytic leukaemia	0.000	0.973	0.027
H33.0 Retinal detachment with retinal break	0.000	0.974	0.026
E27 Other disorders of adrenal gland	0.026	0.974	0.000
E27.1 Primary adrenocortical insufficiency	0.026	0.974	0.000
E24 Cushing's syndrome	0.025	0.975	0.000
E23.7 Disorder of pituitary gland, unspecified	0.025	0.975	0.000
E22 Hyperfunction of pituitary gland	0.025	0.975	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.024	0.976	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.023	0.977	0.000
E26 Hyperaldosteronism	0.023	0.977	0.000
E24.9 Cushing's syndrome, unspecified	0.022	0.978	0.000
E24.0 Pituitary-dependent Cushing's disease	0.022	0.978	0.000
E23.2 Diabetes insipidus	0.021	0.979	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.021	0.979	0.000
E23.1 Drug-induced hypopituitarism	0.021	0.979	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.021	0.979	0.000
E25 Adrenogenital disorders	0.020	0.979	0.000
E31 Polyglandular dysfunction	0.020	0.980	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.020	0.980	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.020	0.980	0.000
E32 Diseases of thymus	0.020	0.980	0.000
E30 Disorders of puberty, not elsewhere classified	0.020	0.980	0.000
E22.0 Acromegaly and pituitary gigantism	0.020	0.980	0.000
E24.8 Other Cushing's syndrome	0.019	0.981	0.000
E24.2 Drug-induced Cushing's syndrome	0.019	0.981	0.000
E26.0 Primary hyperaldosteronism	0.019	0.981	0.000
E27.5 Adrenomedullary hyperfunction	0.019	0.981	0.000
E27.0 Other adrenocortical overactivity	0.019	0.981	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.018	0.981	0.000
E24.3 Ectopic ACTH syndrome	0.018	0.981	0.000
E24.1 Nelson's syndrome	0.018	0.981	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.018	0.982	0.000
E22.8 Other hyperfunction of pituitary gland	0.018	0.982	0.000
E28 Ovarian dysfunction	0.018	0.982	0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract	0.018	0.982	0.000
E27.9 Disorder of adrenal gland, unspecified	0.017	0.983	0.000
E27.2 Addisonian crisis	0.017	0.983	0.000
E26.9 Hyperaldosteronism, unspecified	0.017	0.983	0.000
E29 Testicular dysfunction	0.017	0.983	0.000
E26.8 Other hyperaldosteronism	0.016	0.983	0.000
E26.1 Secondary hyperaldosteronism	0.016	0.983	0.000
E21.3 Hyperparathyroidism, unspecified	0.016	0.984	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.016	0.984	0.000
E23.6 Other disorders of pituitary gland	0.015	0.984	0.000
E20 Hypoparathyroidism	0.015	0.984	0.000
E31.0 Autoimmune polyglandular failure	0.015	0.984	0.000
E21.0 Primary hyperparathyroidism	0.015	0.985	0.000
E25.9 Adrenogenital disorder, unspecified	0.015	0.985	0.000
E25.8 Other adrenogenital disorders	0.015	0.985	0.000
E31.9 Polyglandular dysfunction, unspecified	0.015	0.985	0.000
E31.8 Other polyglandular dysfunction	0.015	0.985	0.000
E31.1 Polyglandular hyperfunction	0.015	0.985	0.000
E21.2 Other hyperparathyroidism	0.015	0.985	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.014	0.985	0.000
E21.4 Other specified disorders of parathyroid gland	0.014	0.985	0.000
E30.9 Disorder of puberty, unspecified	0.014	0.986	0.000
E30.8 Other disorders of puberty	0.014	0.986	0.000
E30.1 Precocious puberty	0.014	0.986	0.000
E30.0 Delayed puberty	0.014	0.986	0.000
E32.9 Disease of thymus, unspecified	0.014	0.986	0.000
E32.8 Other diseases of thymus	0.014	0.986	0.000
E32.1 Abscess of thymus	0.014	0.986	0.000
E32.0 Persistent hyperplasia of thymus	0.014	0.986	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.014	0.986	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.014	0.986	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.014	0.986	0.000
E22.1 Hyperprolactinaemia	0.014	0.986	0.000
Y49.2 Other and unspecified antidepressants	0.014	0.986	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.013	0.987	0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.013	0.987	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.013	0.987	0.000
E28.9 Ovarian dysfunction, unspecified	0.013	0.987	0.000
E28.8 Other ovarian dysfunction	0.013	0.987	0.000
E28.3 Primary ovarian failure	0.013	0.987	0.000
E28.1 Androgen excess	0.013	0.987	0.000
E28.0 Oestrogen excess	0.013	0.987	0.000
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system	0.013	0.987	0.000
R93 Abnormal findings on diagnostic imaging of other body structures	0.013	0.987	0.000
E34 Other endocrine disorders	0.013	0.987	0.000
E29.9 Testicular dysfunction, unspecified	0.012	0.988	0.000
E29.8 Other testicular dysfunction	0.012	0.988	0.000
E29.0 Testicular hyperfunction	0.012	0.988	0.000
R93.4 Abnormal findings on diagnostic imaging of urinary organs	0.012	0.988	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.012	0.988	0.000
R93.0 Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified	0.012	0.988	0.000
E20.8 Other hypoparathyroidism	0.011	0.989	0.000
E20.1 Pseudohypoparathyroidism	0.011	0.989	0.000
E20.0 Idiopathic hypoparathyroidism	0.011	0.989	0.000
E27.8 Other specified disorders of adrenal gland	0.011	0.989	0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.011	0.989	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.011	0.989	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.011	0.989	0.000
E28.2 Polycystic ovarian syndrome	0.011	0.989	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.011	0.989	0.000
Y45.2 Propionic acid derivatives	0.011	0.989	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.010	0.990	0.000
Y49.5 Other antipsychotics and neuroleptics	0.010	0.990	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.010	0.990	0.000
Y47.1 Benzodiazepines	0.010	0.990	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.010	0.990	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.010	0.990	0.000
Z80.0 Family history of malignant neoplasm of digestive organs	0.000	0.990	0.010
Y49.9 Psychotropic drug, unspecified	0.010	0.990	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.010	0.990	0.000
Y49.7 Psychostimulants with abuse potential	0.010	0.990	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.010	0.990	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.010	0.990	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.010	0.990	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.010	0.990	0.000
R93.6 Abnormal findings on diagnostic imaging of limbs	0.010	0.990	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.010	0.990	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.010	0.990	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.010	0.990	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.010	0.990	0.000
Y51.0 Anticholinesterase agents	0.010	0.990	0.000
R39.1 Other difficulties with micturition	0.010	0.990	0.000
E29.1 Testicular hypofunction	0.009	0.990	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.009	0.991	0.000
E34.5 Androgen resistance syndrome	0.009	0.991	0.000
E34.4 Constitutional tall stature	0.009	0.991	0.000
E34.3 Short stature, not elsewhere classified	0.009	0.991	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.009	0.991	0.000
E34.1 Other hypersecretion of intestinal hormones	0.009	0.991	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.009	0.991	0.000
Y52 Agents primarily affecting the cardiovascular system	0.009	0.991	0.000
Y58 Bacterial vaccines	0.009	0.991	0.000
Y59 Other and unspecified vaccines and biological substances	0.009	0.991	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.009	0.991	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.009	0.991	0.000
Y44 Agents primarily affecting blood constituents	0.009	0.991	0.000
N99.3 Prolapse of vaginal vault after hysterectomy	0.009	0.991	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.009	0.991	0.000
Y53.2 Stimulant laxatives	0.008	0.991	0.000
Y43 Primarily systemic agents	0.008	0.992	0.000
E34.9 Endocrine disorder, unspecified	0.008	0.992	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.008	0.992	0.000
Y40 Systemic antibiotics	0.008	0.992	0.000
Y43.1 Antineoplastic antimetabolites	0.008	0.992	0.000
Y48 Anaesthetics and therapeutic gases	0.008	0.992	0.000
J38.3 Other diseases of vocal cords	0.008	0.992	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.008	0.992	0.000
Y45.1 Salicylates	0.008	0.992	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.008	0.992	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.008	0.992	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.008	0.992	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.008	0.992	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.008	0.992	0.000
Y47.4 Bromine compounds	0.008	0.992	0.000
Y47.3 Paraldehyde	0.008	0.992	0.000
Y47.2 Chloral derivatives	0.008	0.992	0.000
Y47.0 Barbiturates, not elsewhere classified	0.008	0.992	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.008	0.992	0.000
Y54.4 Loop [high-ceiling] diuretics	0.008	0.992	0.000
Y54.3 Benzothiadiazine derivatives	0.008	0.992	0.000
Y53.4 Other laxatives	0.008	0.992	0.000
E34.8 Other specified endocrine disorders	0.007	0.992	0.000
N03.9 Unspecified	0.008	0.992	0.000
N08.3 Glomerular disorders in diabetes mellitus	0.008	0.992	0.000
Y44.6 Natural blood and blood products	0.008	0.992	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.008	0.992	0.000
Y54.7 Agents affecting calcification	0.008	0.992	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.007	0.992	0.000
Y53.7 Emetics	0.007	0.992	0.000
Y53.6 Antidiarrhoeal drugs	0.007	0.992	0.000
Y53.5 Digestants	0.007	0.992	0.000
Y53.3 Saline and osmotic laxatives	0.007	0.992	0.000
Y53.0 Histamine H2-receptor antagonists	0.007	0.992	0.000
Y45.5 4-Aminophenol derivatives	0.007	0.992	0.000
E34.0 Carcinoid syndrome	0.007	0.992	0.000
Y41.5 Antiviral drugs	0.007	0.993	0.000
Y45.4 Antirheumatics	0.007	0.993	0.000
E20.9 Hypoparathyroidism, unspecified	0.007	0.993	0.001
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.007	0.993	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.007	0.993	0.000
Y52.7 Peripheral vasodilators	0.007	0.993	0.000
N03 Chronic nephritic syndrome	0.007	0.993	0.000
N02 Recurrent and persistent haematuria	0.007	0.993	0.000
Y55.4 Expectorants	0.007	0.993	0.000
Y52.4 Angiotensin-converting-enzyme inhibitors	0.007	0.993	0.000
Y40.3 Macrolides	0.007	0.993	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.007	0.993	0.000
Y54.9 Mineral salts, not elsewhere classified	0.007	0.993	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.007	0.993	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.007	0.993	0.000
Y54.0 Mineralocorticoids	0.007	0.993	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.007	0.993	0.000
Y58.0 BCG vaccine	0.007	0.993	0.000
R93.2 Abnormal findings on diagnostic imaging of liver and biliary tract	0.007	0.993	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.007	0.993	0.000
Y59.3 Immunoglobulin	0.007	0.993	0.000
N02.8 Other	0.007	0.993	0.000
R93.1 Abnormal findings on diagnostic imaging of heart and coronary circulation	0.007	0.993	0.000
N31.9 Neuromuscular dysfunction of bladder, unspecified	0.007	0.993	0.000
Y43.4 Immunosuppressive agents	0.007	0.993	0.000
Y40.5 Aminoglycosides	0.007	0.993	0.000
N00-N08 Glomerular diseases	0.007	0.993	0.000
Y54.8 Agents affecting uric acid metabolism	0.007	0.993	0.000
Y41.0 Sulphonamides	0.007	0.993	0.000
Y45.8 Other analgesics and antipyretics	0.007	0.993	0.000
Y58.9 Other and unspecified bacterial vaccines	0.007	0.993	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.007	0.993	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.007	0.993	0.000
Y58.5 Diphtheria vaccine	0.007	0.993	0.000
Y58.4 Tetanus vaccine	0.007	0.993	0.000
Y58.3 Plague vaccine	0.007	0.993	0.000
Y58.2 Cholera vaccine	0.007	0.993	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.007	0.993	0.000
Y59.9 Vaccine or biological substance, unspecified	0.007	0.993	0.000
Y59.8 Other specified vaccines and biological substances	0.007	0.993	0.000
Y59.2 Protozoal vaccines	0.007	0.993	0.000
Y59.1 Rickettsial vaccines	0.007	0.993	0.000
Y59.0 Viral vaccines	0.007	0.993	0.000
Y40.6 Rifamycins	0.007	0.993	0.000
Y52.1 Calcium-channel blockers	0.007	0.993	0.000
N80.0 Endometriosis of uterus	0.007	0.993	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.006	0.993	0.000
Y55.5 Anticommon cold drugs	0.006	0.993	0.000
Y55.3 Antitussives	0.006	0.993	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.006	0.993	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.006	0.993	0.000
Y55.0 Oxytocic drugs	0.006	0.993	0.000
N08 Glomerular disorders in diseases classified elsewhere	0.007	0.993	0.000
Y48.4 Anaesthetic, unspecified	0.007	0.993	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.006	0.993	0.000
Y41.4 Anthelminthics	0.006	0.993	0.000
Y41.3 Other antiprotozoal drugs	0.006	0.993	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.006	0.993	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.006	0.993	0.000
Y44.7 Plasma substitutes	0.006	0.993	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.006	0.993	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.006	0.993	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.006	0.993	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.006	0.993	0.000
Y41.1 Antimycobacterial drugs	0.006	0.993	0.000
Y50.9 Central nervous system stimulant, unspecified	0.006	0.993	0.000
Y50.8 Other central nervous system stimulants	0.006	0.993	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.006	0.993	0.000
Y50.1 Opioid receptor antagonists	0.006	0.993	0.000
Y50.0 Analeptics	0.006	0.993	0.000
Y46.7 Anti-Parkinsonism drugs	0.006	0.993	0.000
A04.7 Enterocolitis due to Clostridium difficile	0.000	0.994	0.006
Y43.9 Primarily systemic agent, unspecified	0.006	0.994	0.000
Y43.8 Other primarily systemic agents, not elsewhere classified	0.006	0.994	0.000
Y43.6 Enzymes, not elsewhere classified	0.006	0.994	0.000
Y43.5 Acidifying and alkalising agents	0.006	0.994	0.000
Y43.2 Antineoplastic natural products	0.006	0.994	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.006	0.994	0.000
Y54.5 Other diuretics	0.006	0.994	0.000
Y56.3 Emollients, demulcents and protectants	0.006	0.994	0.000
Y56.9 Topical agent, unspecified	0.006	0.994	0.000
Y56.8 Other topical agents	0.006	0.994	0.000
Y56.7 Dental drugs, topically applied	0.006	0.994	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.006	0.994	0.000
Y56.5 Ophthalmological drugs and preparations	0.006	0.994	0.000
Y56.2 Local astringents and local detergents	0.006	0.994	0.000
Y56.1 Antipruritics	0.006	0.994	0.000
N02.3 Diffuse mesangial proliferative glomerulonephritis	0.006	0.994	0.000
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum	0.006	0.994	0.000
Y40.4 Tetracyclines	0.006	0.994	0.000
Y40.2 Chloramphenicol group	0.006	0.994	0.000
Y40.7 Antifungal antibiotics, systemically used	0.006	0.994	0.000
Y43.0 Antiallergic and antiemetic drugs	0.006	0.994	0.000
Y48.2 Other and unspecified general anaesthetics	0.006	0.994	0.000
Y48.5 Therapeutic gases	0.006	0.994	0.000
Y48.1 Parenteral anaesthetics	0.006	0.994	0.000
Y48.0 Inhaled anaesthetics	0.006	0.994	0.000
R93.8 Abnormal findings on diagnostic imaging of other specified body structures	0.006	0.994	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.006	0.994	0.000
Y46.8 Antispasticity drugs	0.006	0.994	0.000
Y46.5 Valproic acid	0.006	0.994	0.000
Y46.3 Deoxybarbiturates	0.006	0.994	0.000
Y46.1 Oxazolidinediones	0.006	0.994	0.000
Y46.0 Succinimides	0.006	0.994	0.000
Y40.8 Other systemic antibiotics	0.006	0.994	0.000
Y44.5 Thrombolytic drugs	0.006	0.994	0.000
N02.2 Diffuse membranous glomerulonephritis	0.006	0.994	0.000
C69 Malignant neoplasm of eye and adnexa	0.006	0.994	0.000
I73.0 Raynaud's syndrome	0.000	0.994	0.006
Y44.2 Anticoagulants	0.006	0.994	0.000
Y46.6 Other and unspecified antiepileptics	0.006	0.994	0.000
C69.9 Eye, unspecified	0.006	0.994	0.000
N02.0 Minor glomerular abnormality	0.006	0.994	0.000
Y45.0 Opioids and related analgesics	0.005	0.994	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.005	0.995	0.000
Y46.4 Iminostilbenes	0.005	0.995	0.000
N03.5 Diffuse mesangiocapillary glomerulonephritis	0.005	0.995	0.000
Y40.0 Penicillins	0.005	0.995	0.000
N02.7 Diffuse crescentic glomerulonephritis	0.005	0.995	0.000
N02.6 Dense deposit disease	0.005	0.995	0.000
N02.5 Diffuse mesangiocapillary glomerulonephritis	0.005	0.995	0.000
N02.4 Diffuse endocapillary proliferative glomerulonephritis	0.005	0.995	0.000
N02.1 Focal and segmental glomerular lesions	0.005	0.995	0.000
N03.8 Other	0.005	0.995	0.000
N03.7 Diffuse crescentic glomerulonephritis	0.005	0.995	0.000
N03.6 Dense deposit disease	0.005	0.995	0.000
N03.4 Diffuse endocapillary proliferative glomerulonephritis	0.005	0.995	0.000
N03.3 Diffuse mesangial proliferative glomerulonephritis	0.005	0.995	0.000
N03.2 Diffuse membranous glomerulonephritis	0.005	0.995	0.000
N03.1 Focal and segmental glomerular lesions	0.005	0.995	0.000
N03.0 Minor glomerular abnormality	0.005	0.995	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.005	0.995	0.000
N05 Unspecified nephritic syndrome	0.005	0.995	0.000
C71.9 Brain, unspecified	0.005	0.995	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.005	0.995	0.000
C69.3 Choroid	0.005	0.995	0.000
C71 Malignant neoplasm of brain	0.005	0.995	0.000
N07 Hereditary nephropathy, not elsewhere classified	0.005	0.995	0.000
N06 Isolated proteinuria with specified morphological lesion	0.005	0.995	0.000
N01 Rapidly progressive nephritic syndrome	0.005	0.995	0.000
N00 Acute nephritic syndrome	0.005	0.995	0.000
C69.2 Retina	0.005	0.995	0.000
C71.3 Parietal lobe	0.005	0.995	0.000
N08.8 Glomerular disorders in other diseases classified elsewhere	0.005	0.995	0.000
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases	0.005	0.995	0.000
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism	0.005	0.995	0.000
N08.1 Glomerular disorders in neoplastic diseases	0.005	0.995	0.000
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere	0.005	0.995	0.000
Y46.2 Hydantoin derivatives	0.005	0.995	0.000
C71.8 Overlapping lesion of brain	0.005	0.995	0.000
C69.6 Orbit	0.005	0.995	0.000
C91 Lymphoid leukaemia	0.000	0.995	0.005
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.005	0.995	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.005	0.995	0.000
Z89.6 Acquired absence of leg above knee	0.005	0.995	0.000
N05.9 Unspecified	0.005	0.995	0.000
Y57 Other and unspecified drugs and medicaments	0.005	0.995	0.000
N02.9 Unspecified	0.005	0.995	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.004	0.995	0.000
N04 Nephrotic syndrome	0.004	0.995	0.000
N05.7 Diffuse crescentic glomerulonephritis	0.004	0.995	0.000
C69.8 Overlapping lesion of eye and adnexa	0.004	0.996	0.000
C69.5 Lachrymal gland and duct	0.004	0.996	0.000
C69.4 Ciliary body	0.004	0.996	0.000
C69.1 Cornea	0.004	0.996	0.000
C69.0 Conjunctiva	0.004	0.996	0.000
O63.0 Prolonged first stage (of labour)	0.004	0.996	0.000
E10.3 With ophthalmic complications	0.004	0.996	0.000
N05.5 Diffuse mesangiocapillary glomerulonephritis	0.004	0.996	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.004	0.996	0.000
Y48.3 Local anaesthetics	0.004	0.996	0.000
Y40.9 Systemic antibiotic, unspecified	0.004	0.996	0.000
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.004	0.996	0.000
N05.6 Dense deposit disease	0.004	0.996	0.000
N05.4 Diffuse endocapillary proliferative glomerulonephritis	0.004	0.996	0.000
N05.3 Diffuse mesangial proliferative glomerulonephritis	0.004	0.996	0.000
N05.0 Minor glomerular abnormality	0.004	0.996	0.000
C71.0 Cerebrum, except lobes and ventricles	0.004	0.996	0.000
C71.7 Brain stem	0.004	0.996	0.000
C71.6 Cerebellum	0.004	0.996	0.000
C71.5 Cerebral ventricle	0.004	0.996	0.000
N00.9 Unspecified	0.004	0.996	0.000
N00.8 Other	0.004	0.996	0.000
N00.7 Diffuse crescentic glomerulonephritis	0.004	0.996	0.000
N00.6 Dense deposit disease	0.004	0.996	0.000
N00.5 Diffuse mesangiocapillary glomerulonephritis	0.004	0.996	0.000
N00.4 Diffuse endocapillary proliferative glomerulonephritis	0.004	0.996	0.000
N00.3 Diffuse mesangial proliferative glomerulonephritis	0.004	0.996	0.000
N00.2 Diffuse membranous glomerulonephritis	0.004	0.996	0.000
N00.1 Focal and segmental glomerular lesions	0.004	0.996	0.000
N00.0 Minor glomerular abnormality	0.004	0.996	0.000
N01.9 Unspecified	0.004	0.996	0.000
N01.8 Other	0.004	0.996	0.000
N01.7 Diffuse crescentic glomerulonephritis	0.004	0.996	0.000
N01.6 Dense deposit disease	0.004	0.996	0.000
N01.5 Diffuse mesangiocapillary glomerulonephritis	0.004	0.996	0.000
N01.4 Diffuse endocapillary proliferative glomerulonephritis	0.004	0.996	0.000
N01.3 Diffuse mesangial proliferative glomerulonephritis	0.004	0.996	0.000
N01.2 Diffuse membranous glomerulonephritis	0.004	0.996	0.000
N01.1 Focal and segmental glomerular lesions	0.004	0.996	0.000
N01.0 Minor glomerular abnormality	0.004	0.996	0.000
N06.9 Unspecified	0.004	0.996	0.000
N06.8 Other	0.004	0.996	0.000
N06.7 Diffuse crescentic glomerulonephritis	0.004	0.996	0.000
N06.6 Dense deposit disease	0.004	0.996	0.000
N06.5 Diffuse mesangiocapillary glomerulonephritis	0.004	0.996	0.000
N06.4 Diffuse endocapillary proliferative glomerulonephritis	0.004	0.996	0.000
N06.3 Diffuse mesangial proliferative glomerulonephritis	0.004	0.996	0.000
N06.2 Diffuse membranous glomerulonephritis	0.004	0.996	0.000
N06.1 Focal and segmental glomerular lesions	0.004	0.996	0.000
N06.0 Minor glomerular abnormality	0.004	0.996	0.000
N07.9 Unspecified	0.004	0.996	0.000
N07.8 Other	0.004	0.996	0.000
N07.7 Diffuse crescentic glomerulonephritis	0.004	0.996	0.000
N07.6 Dense deposit disease	0.004	0.996	0.000
N07.5 Diffuse mesangiocapillary glomerulonephritis	0.004	0.996	0.000
N07.4 Diffuse endocapillary proliferative glomerulonephritis	0.004	0.996	0.000
N07.3 Diffuse mesangial proliferative glomerulonephritis	0.004	0.996	0.000
N07.2 Diffuse membranous glomerulonephritis	0.004	0.996	0.000
N07.1 Focal and segmental glomerular lesions	0.004	0.996	0.000
N07.0 Minor glomerular abnormality	0.004	0.996	0.000
N05.2 Diffuse membranous glomerulonephritis	0.004	0.996	0.000
C70 Malignant neoplasm of meninges	0.004	0.996	0.000
N05.8 Other	0.004	0.996	0.000
C91.8 Mature B-cell leukaemia Burkitt-type	0.000	0.996	0.003
C91.7 Other lymphoid leukaemia	0.000	0.996	0.003
C91.6 Prolymphocytic leukaemia of T-cell type	0.000	0.996	0.003
C91.5 Adult T-cell leukaemia	0.000	0.996	0.003
C91.3 Prolymphocytic leukaemia	0.000	0.996	0.003
C91.2 Subacute lymphocytic leukaemia	0.000	0.996	0.003
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.003	0.996	0.000
Y57.7 Vitamins, not elsewhere classified	0.003	0.996	0.000
Y57.4 Pharmaceutical excipients	0.003	0.996	0.000
Y57.3 Alcohol deterrents	0.003	0.996	0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified	0.003	0.996	0.000
Y57.1 Lipotropic drugs	0.003	0.996	0.000
Y57.0 Appetite depressants [anorectics]	0.003	0.996	0.000
C71.4 Occipital lobe	0.003	0.996	0.000
N04.8 Other	0.003	0.996	0.000
N04.7 Diffuse crescentic glomerulonephritis	0.003	0.996	0.000
N04.6 Dense deposit disease	0.003	0.996	0.000
N04.5 Diffuse mesangiocapillary glomerulonephritis	0.003	0.996	0.000
N04.4 Diffuse endocapillary proliferative glomerulonephritis	0.003	0.996	0.000
N04.3 Diffuse mesangial proliferative glomerulonephritis	0.003	0.996	0.000
N04.1 Focal and segmental glomerular lesions	0.003	0.996	0.000
N04.0 Minor glomerular abnormality	0.003	0.996	0.000
N04.2 Diffuse membranous glomerulonephritis	0.003	0.997	0.000
N81.9 Female genital prolapse, unspecified	0.003	0.997	0.000
Y57.5 X-ray contrast media	0.003	0.997	0.000
C91.0 Acute lymphoblastic leukaemia	0.000	0.997	0.003
C70.0 Cerebral meninges	0.003	0.997	0.000
Y57.6 Other diagnostic agents	0.003	0.997	0.000
N31.8 Other neuromuscular dysfunction of bladder	0.003	0.997	0.000
N05.1 Focal and segmental glomerular lesions	0.003	0.997	0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified	0.003	0.997	0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum	0.000	0.997	0.003
N08.5 Glomerular disorders in systemic connective tissue disorders	0.003	0.997	0.001
N99.4 Postprocedural pelvic peritoneal adhesions	0.003	0.997	0.000
C70.9 Meninges, unspecified	0.003	0.997	0.000
C70.1 Spinal meninges	0.003	0.997	0.000
Z89.5 Acquired absence of leg at or below knee	0.003	0.997	0.000
N04.9 Unspecified	0.003	0.997	0.000
H35.0 Background retinopathy and retinal vascular changes	0.003	0.997	0.000
H35.8 Other specified retinal disorders	0.003	0.997	0.000
C71.1 Frontal lobe	0.003	0.997	0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified	0.003	0.997	0.000
N85.0 Endometrial glandular hyperplasia	0.003	0.997	0.000
C91.4 Hairy-cell leukaemia	0.000	0.997	0.003
C72.9 Central nervous system, unspecified	0.003	0.997	0.000
C72.8 Overlapping lesion of brain and other parts of central nervous system	0.003	0.997	0.000
C72.5 Other and unspecified cranial nerves	0.003	0.997	0.000
C72.4 Acoustic nerve	0.003	0.997	0.000
C72.3 Optic nerve	0.003	0.997	0.000
C72.2 Olfactory nerve	0.003	0.997	0.000
C72.1 Cauda equina	0.003	0.997	0.000
C72.0 Spinal cord	0.003	0.997	0.000
J01.9 Acute sinusitis, unspecified	0.000	0.997	0.003
N83.0 Follicular cyst of ovary	0.003	0.997	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.003	0.997	0.000
H35.6 Retinal haemorrhage	0.003	0.997	0.000
H35.7 Separation of retinal layers	0.003	0.997	0.000
Y57.8 Other drugs and medicaments	0.002	0.997	0.000
C91.9 Lymphoid leukaemia, unspecified	0.000	0.997	0.002
Y57.9 Drug or medicament, unspecified	0.003	0.997	0.000
M90.75 Fracture of bone in neoplastic disease (Pelvic region and thigh)	0.003	0.997	0.000
S81.8 Open wound of other parts of lower leg	0.000	0.997	0.003
Z89 Acquired absence of limb	0.003	0.997	0.000
S10.9 Superficial injury of neck, part unspecified	0.003	0.997	0.000
N31.0 Uninhibited neuropathic bladder, not elsewhere classified	0.002	0.997	0.000
S32.40 Fracture of acetabulum (closed)	0.000	0.997	0.002
Y42.1 Thyroid hormones and substitutes	0.002	0.998	0.000
K43.0 Ventral hernia with obstruction, without gangrene	0.000	0.998	0.002
N31.1 Reflex neuropathic bladder, not elsewhere classified	0.002	0.998	0.000
J95.8 Other postprocedural respiratory disorders	0.000	0.998	0.002
H35 Other retinal disorders	0.002	0.998	0.000
Z89.8 Acquired absence of upper and lower limbs [any level]	0.002	0.998	0.000
C71.2 Temporal lobe	0.002	0.998	0.000
E11.2 With renal complications	0.002	0.998	0.000
N99.9 Postprocedural disorder of genito-urinary system, unspecified	0.002	0.998	0.000
Z89.2 Acquired absence of upper limb above wrist	0.002	0.998	0.000
N99.5 Malfunction of external stoma of urinary tract	0.002	0.998	0.000
Y42.9 Other and unspecified hormone antagonists	0.002	0.998	0.000
Y42.4 Oral contraceptives	0.002	0.998	0.000
Y42.2 Antithyroid drugs	0.002	0.998	0.000
H35.2 Other proliferative retinopathy	0.002	0.998	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.002	0.998	0.000
Z89.3 Acquired absence of both upper limbs [any level]	0.002	0.998	0.000
Z89.1 Acquired absence of hand and wrist	0.002	0.998	0.000
R30.9 Painful micturition, unspecified	0.000	0.998	0.002

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations