TreeWAS – Variant ID: rs3766113

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.000	0.000	1.000
D68.2 Hereditary deficiency of other clotting factors	0.000	0.000	1.000
I80 Phlebitis and thrombophlebitis	0.000	0.033	0.967
D68 Other coagulation defects	0.000	0.047	0.953
D68.5 Primary Thrombophilia	0.000	0.069	0.931
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.000	0.082	0.918
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.000	0.091	0.909
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.000	0.160	0.840
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.000	0.227	0.773
D68.8 Other specified coagulation defects	0.000	0.233	0.767
I80.8 Phlebitis and thrombophlebitis of other sites	0.000	0.245	0.755
D68.9 Coagulation defect, unspecified	0.000	0.295	0.705
D68.1 Hereditary factor XI deficiency	0.000	0.313	0.687
D68.4 Acquired coagulation factor deficiency	0.000	0.317	0.683
D68.6 Other Thrombophilia	0.000	0.380	0.620
D68.0 Von Willebrand's disease	0.000	0.389	0.611
Z86.7 Personal history of diseases of the circulatory system	0.000	0.519	0.481
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.000	0.534	0.465
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.000	0.704	0.296
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.000	0.766	0.234
D67 Hereditary factor IX deficiency	0.000	0.787	0.212
D66 Hereditary factor VIII deficiency	0.000	0.796	0.204
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.000	0.853	0.147
D69 Purpura and other haemorrhagic conditions	0.000	0.876	0.124
D69.5 Secondary thrombocytopenia	0.000	0.901	0.099
D69.2 Other nonthrombocytopenic purpura	0.000	0.909	0.091
D69.3 Idiopathic thrombocytopenic purpura	0.000	0.910	0.090
D69.9 Haemorrhagic condition, unspecified	0.000	0.910	0.090
D69.8 Other specified haemorrhagic conditions	0.000	0.911	0.089
D69.1 Qualitative platelet defects	0.000	0.911	0.089
D69.4 Other primary thrombocytopenia	0.000	0.913	0.087
I26 Pulmonary embolism	0.000	0.927	0.073
D69.0 Allergic purpura	0.000	0.932	0.068
J31.0 Chronic rhinitis	0.000	0.942	0.058
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.000	0.946	0.054
J31 Chronic rhinitis, nasopharyngitis and pharyngitis	0.000	0.966	0.034
Y42.7 Androgens and anabolic congeners	0.034	0.966	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.029	0.971	0.000
J31.2 Chronic pharyngitis	0.000	0.972	0.028
J31.1 Chronic nasopharyngitis	0.000	0.973	0.027
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.025	0.975	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.025	0.975	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.024	0.976	0.000
Y42.4 Oral contraceptives	0.023	0.977	0.000
K74.3 Primary biliary cirrhosis	0.022	0.978	0.000
M84 Disorders of continuity of bone	0.021	0.979	0.000
Y42.9 Other and unspecified hormone antagonists	0.021	0.979	0.000
M80 Osteoporosis with pathological fracture	0.021	0.979	0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.020	0.980	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.020	0.980	0.000
M84.0 Malunion of fracture	0.020	0.980	0.000
M80-M85 Disorders of bone density and structure	0.020	0.980	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.020	0.980	0.000
Y42.2 Antithyroid drugs	0.019	0.981	0.000
M84.03 Malunion of fracture (Forearm)	0.019	0.981	0.000
M84.4 Pathological fracture, not elsewhere classified	0.019	0.981	0.000
M84.8 Other disorders of continuity of bone	0.018	0.982	0.000
Y42.1 Thyroid hormones and substitutes	0.018	0.982	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.982	0.018
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.018	0.982	0.000
M85 Other disorders of bone density and structure	0.018	0.982	0.000
M84.48 Pathological fracture, not elsewhere classified (Other)	0.018	0.982	0.000
M80.8 Other osteoporosis with pathological fracture	0.016	0.983	0.000
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.016	0.984	0.000
Y40.0 Penicillins	0.016	0.984	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.000	0.984	0.016
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.016	0.984	0.000
Y40 Systemic antibiotics	0.016	0.984	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.016	0.984	0.000
D55-D59 Haemolytic anaemias	0.000	0.984	0.016
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.016	0.984	0.000
K74 Fibrosis and cirrhosis of liver	0.016	0.984	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.016	0.984	0.000
K74.0 Hepatic fibrosis	0.016	0.984	0.000
M84.02 Malunion of fracture (Upper arm)	0.016	0.984	0.000
M84.3 Stress fracture, not elsewhere classified	0.016	0.984	0.000
M85.6 Other cyst of bone	0.016	0.984	0.000
M84.2 Delayed union of fracture	0.015	0.984	0.000
M84.9 Disorder of continuity of bone, unspecified	0.015	0.985	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.015	0.985	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.015	0.985	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.015	0.985	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.015	0.985	0.000
M84.06 Malunion of fracture (Lower leg)	0.015	0.985	0.000
D58 Other hereditary haemolytic anaemias	0.000	0.985	0.015
Y42.5 Other oestrogens and progestogens	0.015	0.985	0.000
M85.0 Fibrous dysplasia (monostotic)	0.015	0.985	0.000
M84.01 Malunion of fracture (Shoulder region)	0.015	0.985	0.000
M84.05 Malunion of fracture (Pelvic region and thigh)	0.015	0.985	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.015	0.985	0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.015	0.985	0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.015	0.985	0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.015	0.985	0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.015	0.985	0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.015	0.985	0.000
Y48 Anaesthetics and therapeutic gases	0.015	0.985	0.000
M83 Adult osteomalacia	0.014	0.985	0.000
M84.09 Malunion of fracture (Site unspecified)	0.014	0.986	0.000
M84.08 Malunion of fracture (Other)	0.014	0.986	0.000
M84.00 Malunion of fracture (Multiple sites)	0.014	0.986	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.014	0.986	0.000
M80.81 Other osteoporosis with pathological fracture (Shoulder region)	0.014	0.986	0.000
M84.41 Pathological fracture, not elsewhere classified (Shoulder region)	0.014	0.986	0.000
Y40.8 Other systemic antibiotics	0.014	0.986	0.000
M85.4 Solitary bone cyst	0.014	0.986	0.000
M84.04 Malunion of fracture (Hand)	0.014	0.986	0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.014	0.986	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.000	0.986	0.014
M80.0 Postmenopausal osteoporosis with pathological fracture	0.014	0.986	0.000
M84.49 Pathological fracture, not elsewhere classified (Site unspecified)	0.014	0.986	0.000
M84.47 Pathological fracture, not elsewhere classified (Ankle and foot)	0.014	0.986	0.000
M84.46 Pathological fracture, not elsewhere classified (Lower leg)	0.014	0.986	0.000
M84.44 Pathological fracture, not elsewhere classified (Hand)	0.014	0.986	0.000
M84.43 Pathological fracture, not elsewhere classified (Forearm)	0.014	0.986	0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)	0.014	0.986	0.000
M84.40 Pathological fracture, not elsewhere classified (Multiple sites)	0.014	0.986	0.000
M85.65 Other cyst of bone (Pelvic region and thigh)	0.014	0.986	0.000
K74.5 Biliary cirrhosis, unspecified	0.014	0.986	0.000
Y48.3 Local anaesthetics	0.014	0.986	0.000
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)	0.014	0.986	0.000
M82 Osteoporosis in diseases classified elsewhere	0.013	0.986	0.000
Y57 Other and unspecified drugs and medicaments	0.013	0.987	0.000
M84.89 Other disorders of continuity of bone (Site unspecified)	0.013	0.987	0.000
M84.88 Other disorders of continuity of bone (Other)	0.013	0.987	0.000
M84.86 Other disorders of continuity of bone (Lower leg)	0.013	0.987	0.000
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.013	0.987	0.000
M84.84 Other disorders of continuity of bone (Hand)	0.013	0.987	0.000
M84.83 Other disorders of continuity of bone (Forearm)	0.013	0.987	0.000
M84.82 Other disorders of continuity of bone (Upper arm)	0.013	0.987	0.000
M84.81 Other disorders of continuity of bone (Shoulder region)	0.013	0.987	0.000
M84.80 Other disorders of continuity of bone (Multiple sites)	0.013	0.987	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.013	0.987	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.013	0.987	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.013	0.987	0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.013	0.987	0.000
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.013	0.987	0.000
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.013	0.987	0.000
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.013	0.987	0.000
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.013	0.987	0.000
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.013	0.987	0.000
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.013	0.987	0.000
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.013	0.987	0.000
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.013	0.987	0.000
M85.5 Aneurysmal bone cyst	0.013	0.987	0.000
M85.3 Osteitis condensans	0.013	0.987	0.000
M85.2 Hyperostosis of skull	0.013	0.987	0.000
M85.1 Skeletal fluorosis	0.013	0.987	0.000
D58.0 Hereditary spherocytosis	0.000	0.987	0.013
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.013	0.987	0.000
M85.66 Other cyst of bone (Lower leg)	0.013	0.987	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.013	0.987	0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.013	0.987	0.000
Y54.8 Agents affecting uric acid metabolism	0.012	0.987	0.000
M81 Osteoporosis without pathological fracture	0.013	0.987	0.000
Y44 Agents primarily affecting blood constituents	0.012	0.988	0.000
D56 Thalassaemia	0.000	0.988	0.012
Y41 Other systemic anti-infectives and antiparasitics	0.012	0.988	0.000
M85.9 Disorder of bone density and structure, unspecified	0.012	0.988	0.000
Y40.4 Tetracyclines	0.012	0.988	0.000
M80.89 Other osteoporosis with pathological fracture (Site unspecified)	0.012	0.988	0.000
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)	0.012	0.988	0.000
M80.86 Other osteoporosis with pathological fracture (Lower leg)	0.012	0.988	0.000
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)	0.012	0.988	0.000
M80.84 Other osteoporosis with pathological fracture (Hand)	0.012	0.988	0.000
M80.83 Other osteoporosis with pathological fracture (Forearm)	0.012	0.988	0.000
M80.82 Other osteoporosis with pathological fracture (Upper arm)	0.012	0.988	0.000
M80.80 Other osteoporosis with pathological fracture (Multiple sites)	0.012	0.988	0.000
M84.45 Pathological fracture, not elsewhere classified (Pelvic region and thigh)	0.012	0.988	0.000
M85.8 Other specified disorders of bone density and structure	0.012	0.988	0.000
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.012	0.988	0.000
Y40.7 Antifungal antibiotics, systemically used	0.012	0.988	0.000
Y40.6 Rifamycins	0.012	0.988	0.000
Y40.2 Chloramphenicol group	0.012	0.988	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.012	0.988	0.000
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)	0.012	0.988	0.000
M80.58 Idiopathic osteoporosis with pathological fracture (Other)	0.012	0.988	0.000
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)	0.012	0.988	0.000
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)	0.012	0.988	0.000
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)	0.012	0.988	0.000
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)	0.012	0.988	0.000
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)	0.012	0.988	0.000
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)	0.012	0.988	0.000
D57 Sickle-cell disorders	0.000	0.988	0.012
D55 Anaemia due to enzyme disorders	0.000	0.988	0.012
D50-D53 Nutritional anaemias	0.000	0.988	0.012
Y48.2 Other and unspecified general anaesthetics	0.012	0.988	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.012	0.988	0.000
K74.4 Secondary biliary cirrhosis	0.012	0.988	0.000
K74.2 Hepatic fibrosis with hepatic sclerosis	0.012	0.988	0.000
K74.1 Hepatic sclerosis	0.012	0.988	0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.012	0.988	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.012	0.988	0.000
Y59 Other and unspecified vaccines and biological substances	0.012	0.988	0.000
Y58 Bacterial vaccines	0.012	0.988	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.012	0.988	0.000
M84.26 Delayed union of fracture (Lower leg)	0.011	0.988	0.000
M85.47 Solitary bone cyst (Ankle and foot)	0.011	0.988	0.000
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.011	0.988	0.000
M84.38 Stress fracture, not elsewhere classified (Other)	0.011	0.988	0.000
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.011	0.988	0.000
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.011	0.988	0.000
M84.34 Stress fracture, not elsewhere classified (Hand)	0.011	0.988	0.000
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.011	0.988	0.000
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.011	0.988	0.000
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.011	0.988	0.000
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.011	0.988	0.000
I20.1 Angina pectoris with documented spasm	0.000	0.988	0.012
Y49.2 Other and unspecified antidepressants	0.011	0.988	0.000
M85.69 Other cyst of bone (Site unspecified)	0.011	0.988	0.000
M85.63 Other cyst of bone (Forearm)	0.011	0.988	0.000
M85.62 Other cyst of bone (Upper arm)	0.011	0.988	0.000
M85.61 Other cyst of bone (Shoulder region)	0.011	0.988	0.000
M85.60 Other cyst of bone (Multiple sites)	0.011	0.988	0.000
M84.29 Delayed union of fracture (Site unspecified)	0.011	0.989	0.000
M84.28 Delayed union of fracture (Other)	0.011	0.989	0.000
M84.27 Delayed union of fracture (Ankle and foot)	0.011	0.989	0.000
M84.25 Delayed union of fracture (Pelvic region and thigh)	0.011	0.989	0.000
M84.24 Delayed union of fracture (Hand)	0.011	0.989	0.000
M84.23 Delayed union of fracture (Forearm)	0.011	0.989	0.000
M84.22 Delayed union of fracture (Upper arm)	0.011	0.989	0.000
M84.21 Delayed union of fracture (Shoulder region)	0.011	0.989	0.000
M84.20 Delayed union of fracture (Multiple sites)	0.011	0.989	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.011	0.989	0.000
D59 Acquired haemolytic anaemia	0.000	0.989	0.011
M85.67 Other cyst of bone (Ankle and foot)	0.011	0.989	0.000
M85.68 Other cyst of bone (Other)	0.011	0.989	0.000
M84.99 Disorder of continuity of bone, unspecified (Site unspecified)	0.011	0.989	0.000
M84.98 Disorder of continuity of bone, unspecified (Other)	0.011	0.989	0.000
M84.97 Disorder of continuity of bone, unspecified (Ankle and foot)	0.011	0.989	0.000
M84.96 Disorder of continuity of bone, unspecified (Lower leg)	0.011	0.989	0.000
M84.95 Disorder of continuity of bone, unspecified (Pelvic region and thigh)	0.011	0.989	0.000
M84.94 Disorder of continuity of bone, unspecified (Hand)	0.011	0.989	0.000
M84.93 Disorder of continuity of bone, unspecified (Forearm)	0.011	0.989	0.000
M84.92 Disorder of continuity of bone, unspecified (Upper arm)	0.011	0.989	0.000
M84.91 Disorder of continuity of bone, unspecified (Shoulder region)	0.011	0.989	0.000
M84.90 Disorder of continuity of bone, unspecified (Multiple sites)	0.011	0.989	0.000
M85.64 Other cyst of bone (Hand)	0.011	0.989	0.000
M80.29 Osteoporosis of disuse with pathological fracture (Site unspecified)	0.011	0.989	0.000
M80.28 Osteoporosis of disuse with pathological fracture (Other)	0.011	0.989	0.000
M80.27 Osteoporosis of disuse with pathological fracture (Ankle and foot)	0.011	0.989	0.000
M80.26 Osteoporosis of disuse with pathological fracture (Lower leg)	0.011	0.989	0.000
M80.25 Osteoporosis of disuse with pathological fracture (Pelvic region and thigh)	0.011	0.989	0.000
M80.24 Osteoporosis of disuse with pathological fracture (Hand)	0.011	0.989	0.000
M80.23 Osteoporosis of disuse with pathological fracture (Forearm)	0.011	0.989	0.000
M80.22 Osteoporosis of disuse with pathological fracture (Upper arm)	0.011	0.989	0.000
M80.21 Osteoporosis of disuse with pathological fracture (Shoulder region)	0.011	0.989	0.000
M80.20 Osteoporosis of disuse with pathological fracture (Multiple sites)	0.011	0.989	0.000
M80.39 Postsurgical malabsorption osteoporosis with pathological fracture (Site unspecified)	0.011	0.989	0.000
M80.38 Postsurgical malabsorption osteoporosis with pathological fracture (Other)	0.011	0.989	0.000
M80.37 Postsurgical malabsorption osteoporosis with pathological fracture (Ankle and foot)	0.011	0.989	0.000
M80.36 Postsurgical malabsorption osteoporosis with pathological fracture (Lower leg)	0.011	0.989	0.000
M80.35 Postsurgical malabsorption osteoporosis with pathological fracture (Pelvic region and thigh)	0.011	0.989	0.000
M80.34 Postsurgical malabsorption osteoporosis with pathological fracture (Hand)	0.011	0.989	0.000
M80.33 Postsurgical malabsorption osteoporosis with pathological fracture (Forearm)	0.011	0.989	0.000
M80.32 Postsurgical malabsorption osteoporosis with pathological fracture (Upper arm)	0.011	0.989	0.000
M80.31 Postsurgical malabsorption osteoporosis with pathological fracture (Shoulder region)	0.011	0.989	0.000
M80.30 Postsurgical malabsorption osteoporosis with pathological fracture (Multiple sites)	0.011	0.989	0.000
M80.49 Drug-induced osteoporosis with pathological fracture (Site unspecified)	0.011	0.989	0.000
M80.48 Drug-induced osteoporosis with pathological fracture (Other)	0.011	0.989	0.000
M80.47 Drug-induced osteoporosis with pathological fracture (Ankle and foot)	0.011	0.989	0.000
M80.46 Drug-induced osteoporosis with pathological fracture (Lower leg)	0.011	0.989	0.000
M80.45 Drug-induced osteoporosis with pathological fracture (Pelvic region and thigh)	0.011	0.989	0.000
M80.44 Drug-induced osteoporosis with pathological fracture (Hand)	0.011	0.989	0.000
M80.43 Drug-induced osteoporosis with pathological fracture (Forearm)	0.011	0.989	0.000
M80.42 Drug-induced osteoporosis with pathological fracture (Upper arm)	0.011	0.989	0.000
M80.41 Drug-induced osteoporosis with pathological fracture (Shoulder region)	0.011	0.989	0.000
M80.40 Drug-induced osteoporosis with pathological fracture (Multiple sites)	0.011	0.989	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.000	0.989	0.011
D58.1 Hereditary elliptocytosis	0.000	0.989	0.011
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.011	0.989	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.011	0.989	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.011	0.989	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.011	0.989	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.011	0.989	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.011	0.989	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.011	0.989	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.011	0.989	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.011	0.989	0.000
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.011	0.989	0.000
M80.88 Other osteoporosis with pathological fracture (Other)	0.011	0.989	0.000
M83.8 Other adult osteomalacia	0.011	0.989	0.000
Y57.5 X-ray contrast media	0.011	0.989	0.000
Y48.5 Therapeutic gases	0.011	0.989	0.000
Y48.1 Parenteral anaesthetics	0.011	0.989	0.000
Y48.0 Inhaled anaesthetics	0.011	0.989	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.011	0.989	0.000
Y57.6 Other diagnostic agents	0.011	0.989	0.000
M83.9 Adult osteomalacia, unspecified	0.010	0.989	0.000
M83.5 Other drug-induced osteomalacia in adults	0.010	0.989	0.000
M83.4 Aluminum bone disease	0.010	0.989	0.000
M83.3 Adult osteomalacia due to malnutrition	0.010	0.989	0.000
M83.2 Adult osteomalacia due to malabsorption	0.010	0.989	0.000
M83.1 Senile osteomalacia	0.010	0.989	0.000
M83.0 Puerperal osteomalacia	0.010	0.989	0.000
Y40.5 Aminoglycosides	0.011	0.989	0.000
Y55.4 Expectorants	0.011	0.989	0.000
I28 Other diseases of pulmonary vessels	0.000	0.989	0.010
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.010	0.989	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.010	0.989	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.010	0.989	0.000
Y40.9 Systemic antibiotic, unspecified	0.010	0.989	0.000
Y40.3 Macrolides	0.010	0.989	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.011	0.989	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.010	0.990	0.000
M85.49 Solitary bone cyst (Site unspecified)	0.010	0.990	0.000
M85.48 Solitary bone cyst (Other)	0.010	0.990	0.000
M85.46 Solitary bone cyst (Lower leg)	0.010	0.990	0.000
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.010	0.990	0.000
M85.44 Solitary bone cyst (Hand)	0.010	0.990	0.000
M85.43 Solitary bone cyst (Forearm)	0.010	0.990	0.000
M85.42 Solitary bone cyst (Upper arm)	0.010	0.990	0.000
M85.41 Solitary bone cyst (Shoulder region)	0.010	0.990	0.000
M85.40 Solitary bone cyst (Multiple sites)	0.010	0.990	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.010	0.990	0.000
M81.4 Drug-induced osteoporosis	0.010	0.990	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.010	0.990	0.000
Y57.8 Other drugs and medicaments	0.010	0.990	0.000
M80.09 Postmenopausal osteoporosis with pathological fracture (Site unspecified)	0.010	0.990	0.000
M80.08 Postmenopausal osteoporosis with pathological fracture (Other)	0.010	0.990	0.000
M80.07 Postmenopausal osteoporosis with pathological fracture (Ankle and foot)	0.010	0.990	0.000
M80.06 Postmenopausal osteoporosis with pathological fracture (Lower leg)	0.010	0.990	0.000
M80.05 Postmenopausal osteoporosis with pathological fracture (Pelvic region and thigh)	0.010	0.990	0.000
M80.04 Postmenopausal osteoporosis with pathological fracture (Hand)	0.010	0.990	0.000
M80.03 Postmenopausal osteoporosis with pathological fracture (Forearm)	0.010	0.990	0.000
M80.02 Postmenopausal osteoporosis with pathological fracture (Upper arm)	0.010	0.990	0.000
M80.01 Postmenopausal osteoporosis with pathological fracture (Shoulder region)	0.010	0.990	0.000
Y54.3 Benzothiadiazine derivatives	0.010	0.990	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.010	0.990	0.000
M82.8 Osteoporosis in other diseases classified elsewhere	0.010	0.990	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.010	0.990	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.010	0.990	0.000
Y48.4 Anaesthetic, unspecified	0.010	0.990	0.000
D52 Folate deficiency anaemia	0.000	0.990	0.010
Y57.7 Vitamins, not elsewhere classified	0.010	0.990	0.000
Y57.4 Pharmaceutical excipients	0.010	0.990	0.000
Y57.3 Alcohol deterrents	0.010	0.990	0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified	0.010	0.990	0.000
Y57.1 Lipotropic drugs	0.010	0.990	0.000
Y57.0 Appetite depressants [anorectics]	0.010	0.990	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.010	0.990	0.000
Y54.9 Mineral salts, not elsewhere classified	0.010	0.990	0.000
Y54.7 Agents affecting calcification	0.010	0.990	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.010	0.990	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.010	0.990	0.000
Y54.0 Mineralocorticoids	0.010	0.990	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.010	0.990	0.000
Y55.5 Anticommon cold drugs	0.010	0.990	0.000
Y55.3 Antitussives	0.010	0.990	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.010	0.990	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.010	0.990	0.000
Y55.0 Oxytocic drugs	0.010	0.990	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.010	0.990	0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.010	0.990	0.000
M85.19 Skeletal fluorosis (Site unspecified)	0.009	0.990	0.000
M85.18 Skeletal fluorosis (Other)	0.009	0.990	0.000
M85.17 Skeletal fluorosis (Ankle and foot)	0.009	0.990	0.000
M85.16 Skeletal fluorosis (Lower leg)	0.009	0.990	0.000
M85.15 Skeletal fluorosis (Pelvic region and thigh)	0.009	0.990	0.000
M85.14 Skeletal fluorosis (Hand)	0.009	0.990	0.000
M85.13 Skeletal fluorosis (Forearm)	0.009	0.990	0.000
M85.12 Skeletal fluorosis (Upper arm)	0.009	0.990	0.000
M85.11 Skeletal fluorosis (Shoulder region)	0.009	0.990	0.000
M85.10 Skeletal fluorosis (Multiple sites)	0.009	0.990	0.000
M85.29 Hyperostosis of skull-Site unspec	0.009	0.990	0.000
M85.28 Hyperostosis of skull-Other	0.009	0.990	0.000
M85.27 Hyperostosis of skull-Ankle/Foot	0.009	0.990	0.000
M85.26 Hyperostosis of skull-Lower Leg	0.009	0.990	0.000
M85.25 Hyperostosis of skull-Pelvic/Thigh	0.009	0.990	0.000
M85.24 Hyperostosis of skull-Hand	0.009	0.990	0.000
M85.23 Hyperostosis of skull-Forearm	0.009	0.990	0.000
M85.22 Hyperostosis of skull-Upper arm	0.009	0.990	0.000
M85.21 Hyperostosis of skull-Shldr region	0.009	0.990	0.000
M85.20 Hyperostosis of skull-Mult sites	0.009	0.990	0.000
M85.39 Osteitis condensans (Site unspecified)	0.009	0.990	0.000
M85.38 Osteitis condensans (Other)	0.009	0.990	0.000
M85.37 Osteitis condensans (Ankle and foot)	0.009	0.990	0.000
M85.36 Osteitis condensans (Lower leg)	0.009	0.990	0.000
M85.35 Osteitis condensans (Pelvic region and thigh)	0.009	0.990	0.000
M85.34 Osteitis condensans (Hand)	0.009	0.990	0.000
M85.33 Osteitis condensans (Forearm)	0.009	0.990	0.000
M85.32 Osteitis condensans (Upper arm)	0.009	0.990	0.000
M85.31 Osteitis condensans (Shoulder region)	0.009	0.990	0.000
M85.30 Osteitis condensans (Multiple sites)	0.009	0.990	0.000
M85.59 Aneurysmal bone cyst (Site unspecified)	0.009	0.990	0.000
M85.58 Aneurysmal bone cyst (Other)	0.009	0.990	0.000
M85.57 Aneurysmal bone cyst (Ankle and foot)	0.009	0.990	0.000
M85.56 Aneurysmal bone cyst (Lower leg)	0.009	0.990	0.000
M85.55 Aneurysmal bone cyst (Pelvic region and thigh)	0.009	0.990	0.000
M85.54 Aneurysmal bone cyst (Hand)	0.009	0.990	0.000
M85.53 Aneurysmal bone cyst (Forearm)	0.009	0.990	0.000
M85.52 Aneurysmal bone cyst (Upper arm)	0.009	0.990	0.000
M85.51 Aneurysmal bone cyst (Shoulder region)	0.009	0.990	0.000
M85.50 Aneurysmal bone cyst (Multiple sites)	0.009	0.990	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.010	0.990	0.000
M07.3 Other psoriatic arthropathies	0.010	0.990	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.009	0.990	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.000	0.990	0.009
D51 Vitamin B12 deficiency anaemia	0.000	0.990	0.010
Y46 Antiepileptics and anti-Parkinsonism drugs	0.009	0.990	0.000
Y41.0 Sulphonamides	0.009	0.991	0.000
Y49.9 Psychotropic drug, unspecified	0.009	0.991	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.009	0.991	0.000
Y49.7 Psychostimulants with abuse potential	0.009	0.991	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.009	0.991	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.009	0.991	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.009	0.991	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.009	0.991	0.000
F32.9 Depressive episode, unspecified	0.009	0.991	0.000
D56.1 Beta thalassaemia	0.000	0.991	0.009
Y57.9 Drug or medicament, unspecified	0.009	0.991	0.000
D53 Other nutritional anaemias	0.000	0.991	0.009
M81.8 Other osteoporosis	0.009	0.991	0.000
M81.6 Localised osteoporosis [Lequesne]	0.009	0.991	0.000
M81.5 Idiopathic osteoporosis	0.009	0.991	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.009	0.991	0.000
M81.1 Postoophorectomy osteoporosis	0.009	0.991	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.009	0.991	0.000
Y44.7 Plasma substitutes	0.009	0.991	0.000
Y44.6 Natural blood and blood products	0.009	0.991	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.009	0.991	0.000
D56.3 Thalassaemia trait	0.000	0.991	0.009
D58.2 Other haemoglobinopathies	0.000	0.991	0.009
M81.0 Postmenopausal osteoporosis	0.009	0.991	0.000
M82.1 Osteoporosis in endocrine disorders	0.009	0.991	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.009	0.991	0.000
D56.9 Thalassaemia, unspecified	0.000	0.991	0.009
D56.8 Other thalassaemias	0.000	0.991	0.009
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.000	0.991	0.009
D56.2 Delta-beta thalassaemia	0.000	0.991	0.009
D56.0 Alpha thalassaemia	0.000	0.991	0.009
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.009	0.991	0.000
Y41.4 Anthelminthics	0.009	0.991	0.000
Y41.3 Other antiprotozoal drugs	0.009	0.991	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.009	0.991	0.000
Y41.1 Antimycobacterial drugs	0.009	0.991	0.000
M85.98 Disorder of bone density and structure, unspecified (Other)	0.009	0.991	0.000
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.009	0.991	0.000
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.009	0.991	0.000
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.009	0.991	0.000
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.009	0.991	0.000
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.009	0.991	0.000
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.009	0.991	0.000
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.009	0.991	0.000
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.009	0.991	0.000
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.009	0.991	0.000
Z83.7 Family history of diseases of the digestive system	0.009	0.991	0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.009	0.991	0.000
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.009	0.991	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.009	0.991	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.009	0.991	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.009	0.991	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.009	0.991	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.008	0.991	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.000	0.991	0.009
D55.8 Other anaemias due to enzyme disorders	0.000	0.991	0.009
D55.3 Anaemia due to disorders of nucleotide metabolism	0.000	0.991	0.009
D55.2 Anaemia due to disorders of glycolytic enzymes	0.000	0.991	0.009
D55.1 Anaemia due to other disorders of glutathione metabolism	0.000	0.991	0.009
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.000	0.991	0.009
D57.8 Other sickle-cell disorders	0.000	0.991	0.009
D57.3 Sickle-cell trait	0.000	0.991	0.009
D57.2 Double heterozygous sickling disorders	0.000	0.991	0.009
D57.1 Sickle-cell anaemia without crisis	0.000	0.991	0.009
D57.0 Sickle-cell anaemia with crisis	0.000	0.991	0.009
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.009	0.991	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.009	0.991	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.009	0.991	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.009	0.991	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.009	0.991	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.009	0.991	0.000
Y51.0 Anticholinesterase agents	0.009	0.991	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.008	0.991	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.008	0.991	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.008	0.991	0.000
Y47.4 Bromine compounds	0.008	0.991	0.000
Y47.3 Paraldehyde	0.008	0.991	0.000
Y47.2 Chloral derivatives	0.008	0.991	0.000
Y47.1 Benzodiazepines	0.009	0.991	0.000
Y47.0 Barbiturates, not elsewhere classified	0.008	0.991	0.000
Y50.9 Central nervous system stimulant, unspecified	0.008	0.991	0.000
Y50.8 Other central nervous system stimulants	0.008	0.991	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.008	0.991	0.000
Y50.1 Opioid receptor antagonists	0.008	0.991	0.000
Y50.0 Analeptics	0.008	0.991	0.000
Y58.9 Other and unspecified bacterial vaccines	0.008	0.991	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.008	0.991	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.008	0.991	0.000
Y58.5 Diphtheria vaccine	0.008	0.991	0.000
Y58.4 Tetanus vaccine	0.008	0.991	0.000
Y58.3 Plague vaccine	0.008	0.991	0.000
Y58.2 Cholera vaccine	0.008	0.991	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.008	0.991	0.000
Y58.0 BCG vaccine	0.008	0.991	0.000
Y59.9 Vaccine or biological substance, unspecified	0.008	0.991	0.000
Y59.8 Other specified vaccines and biological substances	0.008	0.991	0.000
Y59.3 Immunoglobulin	0.008	0.991	0.000
Y59.2 Protozoal vaccines	0.008	0.991	0.000
Y59.1 Rickettsial vaccines	0.008	0.991	0.000
Y59.0 Viral vaccines	0.008	0.991	0.000
M81.2 Osteoporosis of disuse	0.008	0.991	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations