TreeWAS – Variant ID: rs40363

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E87 Other disorders of fluid, electrolyte and acid-base balance	0.022	0.978	0.000
E87.1 Hypo-osmolality and hyponatraemia	0.022	0.978	0.000
E87.3 Alkalosis	0.020	0.980	0.000
E87.6 Hypokalaemia	0.020	0.980	0.000
E87.7 Fluid overload	0.019	0.981	0.000
E87.0 Hyperosmolality and hypernatraemia	0.019	0.981	0.000
E70-E90 Metabolic disorders	0.018	0.982	0.000
E83 Disorders of mineral metabolism	0.017	0.983	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.017	0.983	0.000
E83.4 Disorders of magnesium metabolism	0.017	0.983	0.000
E87.4 Mixed disorder of acid-base balance	0.016	0.984	0.000
E89.0 Postprocedural hypothyroidism	0.016	0.984	0.000
E83.3 Disorders of phosphorus metabolism	0.015	0.985	0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.014	0.985	0.000
E85 Amyloidosis	0.014	0.986	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.014	0.986	0.000
E89.2 Postprocedural hypoparathyroidism	0.014	0.986	0.000
E86 Volume depletion	0.013	0.987	0.000
E88 Other metabolic disorders	0.013	0.987	0.000
E83.5 Disorders of calcium metabolism	0.013	0.987	0.000
E84 Cystic fibrosis	0.013	0.987	0.000
E77 Disorders of glycoprotein metabolism	0.013	0.987	0.000
E76 Disorders of glycosaminoglycan metabolism	0.013	0.987	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.013	0.987	0.000
E72 Other disorders of amino-acid metabolism	0.013	0.987	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.013	0.987	0.000
E70 Disorders of aromatic amino-acid metabolism	0.013	0.987	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.013	0.987	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.012	0.987	0.000
E83.8 Other disorders of mineral metabolism	0.012	0.987	0.000
E83.2 Disorders of zinc metabolism	0.012	0.987	0.000
E83.0 Disorders of copper metabolism	0.012	0.987	0.000
E89.4 Postprocedural ovarian failure	0.012	0.988	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.012	0.988	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.012	0.988	0.000
E89.5 Postprocedural testicular hypofunction	0.012	0.988	0.000
E89.1 Postprocedural hypoinsulinaemia	0.012	0.988	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.012	0.988	0.000
E79 Disorders of purine and pyrimidine metabolism	0.012	0.988	0.000
E85.4 Organ-limited amyloidosis	0.012	0.988	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.012	0.988	0.000
E87.2 Acidosis	0.012	0.988	0.000
E73 Lactose intolerance	0.011	0.988	0.000
E85.9 Amyloidosis, unspecified	0.011	0.989	0.000
E74 Other disorders of carbohydrate metabolism	0.011	0.989	0.000
C78.2 Secondary malignant neoplasm of pleura	0.011	0.989	0.000
E83.1 Disorders of iron metabolism	0.011	0.989	0.000
E87.5 Hyperkalaemia	0.011	0.989	0.000
E85.8 Other amyloidosis	0.010	0.989	0.000
E85.2 Heredofamilial amyloidosis, unspecified	0.010	0.989	0.000
E85.1 Neuropathic heredofamilial amyloidosis	0.010	0.989	0.000
E85.0 Nonneuropathic heredofamilial amyloidosis	0.010	0.989	0.000
G62.8 Other specified polyneuropathies	0.010	0.990	0.000
E88.3 Tumour lysis syndrome	0.010	0.990	0.000
E88.2 Lipomatosis, not elsewhere classified	0.010	0.990	0.000
E85.3 Secondary systemic amyloidosis	0.010	0.990	0.000
E88.8 Other specified metabolic disorders	0.010	0.990	0.000
E89.3 Postprocedural hypopituitarism	0.010	0.990	0.000
E88.9 Metabolic disorder, unspecified	0.009	0.990	0.000
E88.1 Lipodystrophy, not elsewhere classified	0.009	0.990	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.009	0.991	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.009	0.991	0.000
E70.3 Albinism	0.009	0.991	0.000
E70.2 Disorders of tyrosine metabolism	0.009	0.991	0.000
E70.1 Other hyperphenylalaninaemias	0.009	0.991	0.000
E70.0 Classical phenylketonuria	0.009	0.991	0.000
E71.3 Disorders of fatty-acid metabolism	0.009	0.991	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.009	0.991	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.009	0.991	0.000
E71.0 Maple-syrup-urine disease	0.009	0.991	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.009	0.991	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.009	0.991	0.000
E72.5 Disorders of glycine metabolism	0.009	0.991	0.000
E72.4 Disorders of ornithine metabolism	0.009	0.991	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.009	0.991	0.000
E72.2 Disorders of urea cycle metabolism	0.009	0.991	0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.009	0.991	0.000
E72.0 Disorders of amino-acid transport	0.009	0.991	0.000
E75.6 Lipid storage disorder, unspecified	0.009	0.991	0.000
E75.5 Other lipid storage disorders	0.009	0.991	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.009	0.991	0.000
E75.3 Sphingolipidosis, unspecified	0.009	0.991	0.000
E75.2 Other sphingolipidosis	0.009	0.991	0.000
E75.1 Other gangliosidosis	0.009	0.991	0.000
E75.0 GM2 gangliosidosis	0.009	0.991	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.009	0.991	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.009	0.991	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.009	0.991	0.000
E76.2 Other mucopolysaccharidoses	0.009	0.991	0.000
E76.1 Mucopolysaccharidosis, type II	0.009	0.991	0.000
E76.0 Mucopolysaccharidosis, type I	0.009	0.991	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.009	0.991	0.000
E77.8 Other disorders of glycoprotein metabolism	0.009	0.991	0.000
E77.1 Defects in glycoprotein degradation	0.009	0.991	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.009	0.991	0.000
E84.9 Cystic fibrosis, unspecified	0.009	0.991	0.000
E84.8 Cystic fibrosis with other manifestations	0.009	0.991	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.009	0.991	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.009	0.991	0.000
G62 Other polyneuropathies	0.009	0.991	0.000
E80.2 Other porphyria	0.009	0.991	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.009	0.991	0.000
E80.5 Crigler-Najjar syndrome	0.009	0.991	0.000
E80.3 Defects of catalase and peroxydase	0.009	0.991	0.000
E80.1 Porphyria cutanea tarda	0.009	0.991	0.000
E80.0 Hereditary erythropoietic porphyria	0.009	0.991	0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.009	0.991	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.009	0.991	0.000
E79.1 Lesch-Nyhan syndrome	0.009	0.991	0.000
M24.1 Other articular cartilage disorders	0.009	0.991	0.000
G62.9 Polyneuropathy, unspecified	0.009	0.991	0.000
E80.4 Gilbert's syndrome	0.009	0.991	0.000
E73.8 Other lactose intolerance	0.008	0.991	0.000
E73.1 Secondary lactase deficiency	0.008	0.991	0.000
E73.0 Congenital lactase deficiency	0.008	0.991	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.008	0.992	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.008	0.992	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.008	0.992	0.000
E74.2 Disorders of galactose metabolism	0.008	0.992	0.000
E74.1 Disorders of fructose metabolism	0.008	0.992	0.000
E74.0 Glycogen storage disease	0.008	0.992	0.000
E80.6 Other disorders of bilirubin metabolism	0.008	0.992	0.000
Q54 Hypospadias	0.008	0.992	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.008	0.992	0.000
M24.17 Other articular cartilage disorders (Ankle and foot)	0.008	0.992	0.000
Q50-Q56 Congenital malformations of genital organs	0.008	0.992	0.000
S32.40 Fracture of acetabulum (closed)	0.000	0.992	0.008
M24.11 Other articular cartilage disorders (Shoulder region)	0.008	0.992	0.000
M24.13 Other articular cartilage disorders (Forearm)	0.008	0.992	0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.008	0.992	0.000
E73.9 Lactose intolerance, unspecified	0.007	0.993	0.000
Q51 Congenital malformations of uterus and cervix	0.007	0.993	0.000
Q54.1 Hypospadias, penile	0.007	0.993	0.000
Q54.0 Hypospadias, balanic	0.007	0.993	0.000
D17.0 Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck	0.007	0.993	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.007	0.993	0.000
G62.2 Polyneuropathy due to other toxic agents	0.007	0.993	0.000
Q54.8 Other hypospadias	0.007	0.993	0.000
Q54.9 Hypospadias, unspecified	0.007	0.993	0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.000	0.993	0.007
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.007	0.993	0.000
M24.19 Other articular cartilage disorders (Site unspecified)	0.007	0.993	0.000
M24.18 Other articular cartilage disorders (Other)	0.007	0.993	0.000
M24.14 Other articular cartilage disorders (Hand)	0.007	0.993	0.000
M24.12 Other articular cartilage disorders (Upper arm)	0.007	0.993	0.000
M24.10 Other articular cartilage disorders (Multiple sites)	0.007	0.993	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.007	0.993	0.000
H40.0 Glaucoma suspect	0.006	0.994	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.006	0.994	0.000
Q52 Other congenital malformations of female genitalia	0.006	0.994	0.000
G61 Inflammatory polyneuropathy	0.006	0.994	0.000
Q65 Congenital deformities of hip	0.006	0.994	0.000
G60 Hereditary and idiopathic neuropathy	0.006	0.994	0.000
G62.0 Drug-induced polyneuropathy	0.006	0.994	0.000
Q65.8 Other congenital deformities of hip	0.006	0.994	0.000
G61.0 Guillain-Barre syndrome	0.006	0.994	0.000
G62.1 Alcoholic polyneuropathy	0.006	0.994	0.000
Q50 Congenital malformations of ovaries, Fallopian tubes and broad ligaments	0.006	0.994	0.000
Q51.2 Other doubling of uterus	0.006	0.994	0.000
Q54.4 Congenital chordee	0.006	0.994	0.000
Q54.3 Hypospadias, perineal	0.006	0.994	0.000
Q54.2 Hypospadias, penoscrotal	0.006	0.994	0.000
Q51.3 Bicornate uterus	0.006	0.994	0.000
G60.0 Hereditary motor and sensory neuropathy	0.006	0.994	0.000
H57.9 Disorder of eye and adnexa, unspecified	0.006	0.994	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.000	0.994	0.006
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.006	0.994	0.000
Q51.8 Other congenital malformations of uterus and cervix	0.006	0.994	0.000
Q56 Indeterminate sex and pseudohermaphroditism	0.006	0.994	0.000
Q76 Congenital malformations of spine and bony thorax	0.006	0.994	0.000
M84.11 Nonunion of fracture [pseudarthrosis] (Shoulder region)	0.000	0.994	0.006
Q55 Other congenital malformations of male genital organs	0.005	0.994	0.000
Q67 Congenital musculoskeletal deformities of head, face, spine and chest	0.005	0.995	0.000
Q51.9 Congenital malformation of uterus and cervix, unspecified	0.005	0.995	0.000
Q51.7 Congenital fistulae between uterus and digestive and urinary tracts	0.005	0.995	0.000
Q51.6 Embryonic cyst of cervix	0.005	0.995	0.000
Q51.5 Agenesis and aplasia of cervix	0.005	0.995	0.000
Q51.4 Unicornate uterus	0.005	0.995	0.000
Q51.1 Doubling of uterus with doubling of cervix and vagina	0.005	0.995	0.000
Q51.0 Agenesis and aplasia of uterus	0.005	0.995	0.000
G61.9 Inflammatory polyneuropathy, unspecified	0.005	0.995	0.000
Q17 Other congenital malformations of ear	0.005	0.995	0.000
Q66 Congenital deformities of feet	0.005	0.995	0.000
Q52.5 Fusion of labia	0.005	0.995	0.000
Q76.4 Other congenital malformations of spine, not associated with scoliosis	0.005	0.995	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.005	0.995	0.000
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.000	0.995	0.005
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.005	0.995	0.000
G60.9 Hereditary and idiopathic neuropathy, unspecified	0.005	0.995	0.000
C18.0 Caecum	0.000	0.995	0.005
Q74 Other congenital malformations of limb(s)	0.005	0.995	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.005	0.995	0.000
C18.2 Ascending colon	0.000	0.995	0.005
L02.3 Cutaneous abscess, furuncle and carbuncle of buttock	0.005	0.995	0.000
Q50.4 Embryonic cyst of Fallopian tube	0.005	0.995	0.000
N60 Benign mammary dysplasia	0.005	0.995	0.000
N83.8 Other noninflammatory disorders of ovary, Fallopian tube and broad ligament	0.000	0.995	0.005
Q77 Osteochondrodysplasia with defects of growth of tubular bones and spine	0.005	0.995	0.000
Q75 Other congenital malformations of skull and face bones	0.005	0.995	0.000
Q73 Reduction defects of unspecified limb	0.005	0.995	0.000
Q72 Reduction defects of lower limb	0.005	0.995	0.000
Q71 Reduction defects of upper limb	0.005	0.995	0.000
Q70 Syndactyly	0.005	0.995	0.000
Q69 Polydactyly	0.005	0.995	0.000
Q68 Other congenital musculoskeletal deformities	0.005	0.995	0.000
G64 Other disorders of peripheral nervous system	0.005	0.995	0.000
Q17.5 Prominent ear	0.005	0.995	0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified	0.005	0.995	0.000
Q15 Other congenital malformations of eye	0.005	0.995	0.000
Q52.1 Doubling of vagina	0.005	0.995	0.000
Q00-Q07 Congenital malformations of the nervous system	0.005	0.995	0.000
Q53 Undescended testicle	0.005	0.995	0.000
Q35-Q37 Cleft lip and cleft palate	0.005	0.995	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.005	0.995	0.000
N60.3 Fibrosclerosis of breast	0.005	0.995	0.000
Q52.9 Congenital malformation of female genitalia, unspecified	0.005	0.995	0.000
Q52.8 Other specified congenital malformations of female genitalia	0.005	0.995	0.000
Q52.7 Other congenital malformations of vulva	0.005	0.995	0.000
Q52.6 Congenital malformation of clitoris	0.005	0.995	0.000
Q52.4 Other congenital malformations of vagina	0.005	0.995	0.000
Q52.3 Imperforate hymen	0.005	0.995	0.000
Q52.2 Congenital rectovaginal fistula	0.005	0.995	0.000
Q52.0 Congenital absence of vagina	0.005	0.995	0.000
G61.1 Serum neuropathy	0.005	0.995	0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.000	0.995	0.005
Q65.9 Congenital deformity of hip, unspecified	0.005	0.995	0.000
Q65.6 Unstable hip	0.005	0.995	0.000
Q65.5 Congenital subluxation of hip, unspecified	0.005	0.995	0.000
Q65.4 Congenital subluxation of hip, bilateral	0.005	0.995	0.000
Q65.3 Congenital subluxation of hip, unilateral	0.005	0.995	0.000
Q65.2 Congenital dislocation of hip, unspecified	0.005	0.995	0.000
Q65.1 Congenital dislocation of hip, bilateral	0.005	0.995	0.000
Q65.0 Congenital dislocation of hip, unilateral	0.005	0.995	0.000
G60.3 Idiopathic progressive neuropathy	0.005	0.995	0.000
G60.2 Neuropathy in association with hereditary ataxia	0.005	0.995	0.000
G60.1 Refsum's disease	0.005	0.995	0.000
Q78 Other osteochondrodysplasias	0.005	0.995	0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.000	0.995	0.005
N60.1 Diffuse cystic mastopathy	0.005	0.995	0.000
N60.9 Benign mammary dysplasia, unspecified	0.005	0.995	0.000
Q50.6 Other congenital malformatons of Fallopian tube and broad ligament	0.004	0.995	0.000
Q50.3 Other congenital malformations of ovary	0.004	0.995	0.000
Q50.2 Congenital torsion of ovary	0.004	0.995	0.000
Q50.1 Developmental ovarian cyst	0.004	0.995	0.000
Q50.0 Congenital absence of ovary	0.004	0.995	0.000
Q12 Congenital lens malformations	0.005	0.995	0.000
Q66.8 Other congenital deformities of feet	0.005	0.995	0.000
Q45 Other congenital malformations of digestive system	0.005	0.995	0.000
Q67.6 Pectus excavatum	0.005	0.995	0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.000	0.995	0.004
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.000	0.995	0.004
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.000	0.995	0.004
N60.2 Fibroadenosis of breast	0.005	0.995	0.000
M24.16 Other articular cartilage disorders (Lower leg)	0.005	0.995	0.000
Q10 Congenital malformations of eyelid, lachrymal apparatus and orbit	0.004	0.995	0.000
Q67.4 Other congenital deformities of skull, face and jaw	0.004	0.995	0.000
Q16 Congenital malformations of ear causing impairment of hearing	0.004	0.995	0.000
Q14 Congenital malformations of posterior segment of eye	0.004	0.995	0.000
Q13 Congenital malformations of anterior segment of eye	0.004	0.995	0.000
Q11 Anophthalmos, microphthalmos and macrophthalmos	0.004	0.995	0.000
Q98 Other sex chromosome abnormalities, male phenotype, not elsewhere classified	0.004	0.996	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.004	0.996	0.000
Q56.4 Indeterminate sex, unspecified	0.004	0.996	0.000
Q56.3 Pseudohermaphroditism, unspecified	0.004	0.996	0.000
Q56.2 Female pseudohermaphroditism, not elsewhere classified	0.004	0.996	0.000
Q56.1 Male pseudohermaphroditism, not elsewhere classified	0.004	0.996	0.000
Q56.0 Hermaphroditism, not elsewhere classified	0.004	0.996	0.000
Y40.8 Other systemic antibiotics	0.004	0.996	0.000
Q50.5 Embryonic cyst of broad ligament	0.004	0.996	0.000
N60.4 Mammary duct ectasia	0.004	0.996	0.000
Q15.0 Congenital glaucoma	0.004	0.996	0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.004	0.996	0.000
Q76.9 Congenital malformation of bony thorax, unspecified	0.004	0.996	0.000
Q76.8 Other congenital malformations of bony thorax	0.004	0.996	0.000
Q76.7 Congenital malformation of sternum	0.004	0.996	0.000
Q76.6 Other congenital malformations of ribs	0.004	0.996	0.000
Q76.5 Cervical rib	0.004	0.996	0.000
Q76.3 Congenital scoliosis due to congenital bony malformation	0.004	0.996	0.000
Q76.2 Congenital spondylolisthesis	0.004	0.996	0.000
Q76.1 Klippel-Feil syndrome	0.004	0.996	0.000
M84.15 Nonunion of fracture [pseudarthrosis] (Pelvic region and thigh)	0.000	0.996	0.004
G60.8 Other hereditary and idiopathic neuropathies	0.004	0.996	0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.000	0.996	0.004
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.004	0.996	0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.000	0.996	0.004
Q60-Q64 Congenital malformations of the urinary system	0.004	0.996	0.000
Q55.9 Congenital malformation of male genital organ, unspecified	0.004	0.996	0.000
Q55.8 Other specified congenital malformations of male genital organs	0.004	0.996	0.000
Q55.5 Congenital absence and aplasia of penis	0.004	0.996	0.000
Q55.4 Other congenital malformations of vas deferens, epididymis, seminal vesicles and prostate	0.004	0.996	0.000
Q55.3 Atresia of vas deferens	0.004	0.996	0.000
Q55.2 Other congenital malformations of testis and scrotum	0.004	0.996	0.000
Q55.1 Hypoplasia of testis and scrotum	0.004	0.996	0.000
Q55.0 Absence and aplasia of testis	0.004	0.996	0.000
G61.8 Other inflammatory polyneuropathies	0.004	0.996	0.000
H92.1 Otorrhoea	0.004	0.996	0.000
Q67.8 Other congenital deformities of chest	0.004	0.996	0.000
Q67.7 Pectus carinatum	0.004	0.996	0.000
Q67.3 Plagiocephaly	0.004	0.996	0.000
Q67.2 Dolichocephaly	0.004	0.996	0.000
Q67.1 Compression facies	0.004	0.996	0.000
Q67.0 Facial asymmetry	0.004	0.996	0.000
Q74.2 Other congenital malformations of lower limb(s), including pelvic girdle	0.004	0.996	0.000
Q99 Other chromosome abnormalities, not elsewhere classified	0.004	0.996	0.000
Q45.3 Other congenital malformations of pancreas and pancreatic duct	0.004	0.996	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.004	0.996	0.000
Q79.8 Other congenital malformations of musculoskeletal system	0.004	0.996	0.000
S32.4 Fracture of acetabulum	0.000	0.996	0.004
Q17.9 Congenital malformation of ear, unspecified	0.004	0.996	0.000
Q17.8 Other specified congenital malformations of ear	0.004	0.996	0.000
Q17.4 Misplaced ear	0.004	0.996	0.000
Q17.3 Other misshapen ear	0.004	0.996	0.000
Q17.2 Microtia	0.004	0.996	0.000
Q17.1 Macrotia	0.004	0.996	0.000
Q17.0 Accessory auricle	0.004	0.996	0.000
Q66.9 Congenital deformity of feet, unspecified	0.004	0.996	0.000
Q66.6 Other congenital valgus deformities of feet	0.004	0.996	0.000
Q66.5 Congenital pes planus	0.004	0.996	0.000
Q66.4 Talipes calcaneovalgus	0.004	0.996	0.000
Q66.1 Talipes calcaneovarus	0.004	0.996	0.000
Q66.0 Talipes equinovarus	0.004	0.996	0.000
N60.8 Other benign mammary dysplasias	0.004	0.996	0.000
Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified	0.004	0.996	0.000
Q96 Turner's syndrome	0.004	0.996	0.000
Q95 Balanced rearrangements and structural markers, not elsewhere classified	0.004	0.996	0.000
Q93 Monosomies and deletions from the autosomes, not elsewhere classified	0.004	0.996	0.000
Q92 Other trisomies and partial trisomies of the autosomes, not elsewhere classified	0.004	0.996	0.000
Q91 Edwards' syndrome and Patau's syndrome	0.004	0.996	0.000
Q18 Other congenital malformations of face and neck	0.004	0.996	0.000
Q90 Down's syndrome	0.004	0.996	0.000
Q66.2 Metatarsus varus	0.004	0.996	0.000
Q27 Other congenital malformations of peripheral vascular system	0.004	0.996	0.000
Q40 Other congenital malformations of upper alimentary tract	0.004	0.996	0.000
Q55.6 Other congenital malformations of penis	0.004	0.996	0.000
Q74.9 Unspecified congenital malformation of limb(s)	0.004	0.996	0.000
Q74.8 Other specified congenital malformations of limb(s)	0.004	0.996	0.000
Q74.3 Arthrogryposis multiplex congenita	0.004	0.996	0.000
Q74.1 Congenital malformation of knee	0.004	0.996	0.000
Q66.7 Pes cavus	0.004	0.996	0.000
Q07 Other congenital malformations of nervous system	0.004	0.996	0.000
Q42 Congenital absence, atresia and stenosis of large intestine	0.004	0.996	0.000
Q41 Congenital absence, atresia and stenosis of small intestine	0.004	0.996	0.000
Q66.3 Other congenital varus deformities of feet	0.004	0.996	0.000
C18 Malignant neoplasm of colon	0.000	0.996	0.004
Q74.0 Other congenital malformations of upper limb(s), including shoulder girdle	0.004	0.996	0.000
Q68.8 Other specified congenital musculoskeletal deformities	0.004	0.996	0.000
Q68.5 Congenital bowing of long bones of leg, unspecified	0.004	0.996	0.000
Q68.4 Congenital bowing of tibia and fibula	0.004	0.996	0.000
Q68.3 Congenital bowing of femur	0.004	0.996	0.000
Q68.2 Congenital deformity of knee	0.004	0.996	0.000
Q68.1 Congenital deformity of hand	0.004	0.996	0.000
Q68.0 Congenital deformity of sternocleidomastoid muscle	0.004	0.996	0.000
Q69.9 Polydactyly, unspecified	0.004	0.996	0.000
Q69.2 Accessory toe(s)	0.004	0.996	0.000
Q69.1 Accessory thumb(s)	0.004	0.996	0.000
Q69.0 Accessory finger(s)	0.004	0.996	0.000
Q70.9 Syndactyly, unspecified	0.004	0.996	0.000
Q70.4 Polysyndactyly	0.004	0.996	0.000
Q70.3 Webbed toes	0.004	0.996	0.000
Q70.2 Fused toes	0.004	0.996	0.000
Q70.1 Webbed fingers	0.004	0.996	0.000
Q70.0 Fused fingers	0.004	0.996	0.000
Q71.9 Reduction defect of upper limb, unspecified	0.004	0.996	0.000
Q71.8 Other reduction defects of upper limb(s)	0.004	0.996	0.000
Q71.6 Lobster-claw hand	0.004	0.996	0.000
Q71.5 Longitudinal reduction defect of ulna	0.004	0.996	0.000
Q71.4 Longitudinal reduction defect of radius	0.004	0.996	0.000
Q71.3 Congenital absence of hand and finger(s)	0.004	0.996	0.000
Q71.2 Congenital absence of both forearm and hand	0.004	0.996	0.000
Q71.1 Congenital absence of upper arm and forearm with hand present	0.004	0.996	0.000
Q71.0 Congenital complete absence of upper limb(s)	0.004	0.996	0.000
Q72.9 Reduction defect of lower limb, unspecified	0.004	0.996	0.000
Q72.8 Other reduction defects of lower limb(s)	0.004	0.996	0.000
Q72.7 Split foot	0.004	0.996	0.000
Q72.6 Longitudinal reduction defect of fibula	0.004	0.996	0.000
Q72.5 Longitudinal reduction defect of tibia	0.004	0.996	0.000
Q72.4 Longitudinal reduction defect of femur	0.004	0.996	0.000
Q72.3 Congenital absence of foot and toe(s)	0.004	0.996	0.000
Q72.2 Congenital absence of both lower leg and foot	0.004	0.996	0.000
Q72.1 Congenital absence of thigh and lower leg with foot present	0.004	0.996	0.000
Q72.0 Congenital complete absence of lower limb(s)	0.004	0.996	0.000
Q73.8 Other reduction defects of unspecified limb(s)	0.004	0.996	0.000
Q73.1 Phocomelia, unspecified limb(s)	0.004	0.996	0.000
Q73.0 Congenital absence of unspecified limb(s)	0.004	0.996	0.000
Q75.9 Congenital malformation of skull and face bones, unspecified	0.004	0.996	0.000
Q75.8 Other specified congenital malformations of skull and face bones	0.004	0.996	0.000
Q75.5 Oculomandibular dysostosis	0.004	0.996	0.000
Q75.4 Mandibulofacial dysostosis	0.004	0.996	0.000
Q75.3 Macrocephaly	0.004	0.996	0.000
Q75.2 Hypertelorism	0.004	0.996	0.000
Q75.1 Craniofacial dysostosis	0.004	0.996	0.000
Q75.0 Craniosynostosis	0.004	0.996	0.000
Q77.9 Osteochondrodysplasia with defects of growth of tubular bones and spine, unspecified	0.004	0.996	0.000
Q77.8 Other osteochondrodysplasia with defects of growth of tubular bones and spine	0.004	0.996	0.000
Q77.7 Spondyloepiphyseal dysplasia	0.004	0.996	0.000
Q77.6 Chondroectodermal dysplasia	0.004	0.996	0.000
Q77.5 Diastrophic dysplasia	0.004	0.996	0.000
Q77.4 Achondroplasia	0.004	0.996	0.000
Q77.3 Chondrodysplasia punctata	0.004	0.996	0.000
Q77.2 Short rib syndrome	0.004	0.996	0.000
Q77.1 Thanatophoric short stature	0.004	0.996	0.000
Q77.0 Achondrogenesis	0.004	0.996	0.000
M23.8 Other internal derangements of knee	0.004	0.996	0.000
Q79.9 Congenital malformation of musculoskeletal system, unspecified	0.004	0.996	0.000
Q79.5 Other congenital malformations of abdominal wall	0.004	0.996	0.000
Q79.4 Prune belly syndrome	0.004	0.996	0.000
Q79.3 Gastroschisis	0.004	0.996	0.000
Q79.2 Exomphalos	0.004	0.996	0.000
Q79.1 Other congenital malformations of diaphragm	0.004	0.996	0.000
Q79.0 Congenital diaphragmatic hernia	0.004	0.996	0.000
Q98.4 Klinefelter's syndrome, unspecified	0.004	0.996	0.000
Q15.9 Congenital malformation of eye, unspecified	0.004	0.996	0.000
Q15.8 Other specified congenital malformations of eye	0.004	0.996	0.000
Q04 Other congenital malformations of brain	0.004	0.996	0.000
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.004	0.996	0.000
Q06 Other congenital malformations of spinal cord	0.004	0.996	0.000
Q03 Congenital hydrocephalus	0.004	0.996	0.000
Q01 Encephalocele	0.004	0.996	0.000
Q00 Anencephaly and similar malformations	0.004	0.996	0.000
Q02 Microcephaly	0.004	0.996	0.000
Q43 Other congenital malformations of intestine	0.004	0.996	0.000
Q53.9 Undescended testicle, unspecified	0.004	0.996	0.000
Q53.2 Undescended testicle, bilateral	0.004	0.996	0.000
Q53.0 Ectopic testis	0.004	0.996	0.000
Q76.0 Spina bifida occulta	0.004	0.996	0.000
Q45.8 Other specified congenital malformations of digestive system	0.004	0.996	0.000
Q34 Other congenital malformations of respiratory system	0.004	0.996	0.000
Q33 Congenital malformations of lung	0.004	0.996	0.000
Q32 Congenital malformations of trachea and bronchus	0.004	0.996	0.000
Q31 Congenital malformations of larynx	0.004	0.996	0.000
Q30 Congenital malformations of nose	0.004	0.996	0.000
Q37 Cleft palate with cleft lip	0.004	0.996	0.000
Q36 Cleft lip	0.004	0.996	0.000
Q35 Cleft palate	0.004	0.996	0.000
Q67.5 Congenital deformity of spine	0.004	0.996	0.000
Q12.0 Congenital cataract	0.004	0.996	0.000
Q21 Congenital malformations of cardiac septa	0.004	0.996	0.000
G63 Polyneuropathy in diseases classified elsewhere	0.004	0.996	0.000
Q78.9 Osteochondrodysplasia, unspecified	0.003	0.996	0.000
Q78.8 Other specified osteochondrodysplasias	0.003	0.996	0.000
Q78.6 Multiple congenital exostoses	0.003	0.996	0.000
Q78.5 Metaphyseal dysplasia	0.003	0.996	0.000
Q78.4 Enchondromatosis	0.003	0.996	0.000
Q78.3 Progressive diaphyseal dysplasia	0.003	0.996	0.000
Q78.2 Osteopetrosis	0.003	0.996	0.000
Q78.1 Polyostotic fibrous dysplasia	0.003	0.996	0.000
R45.2 Unhappiness	0.004	0.996	0.000
Q27.9 Congenital malformation of peripheral vascular system, unspecified	0.004	0.996	0.000
R45.1 Restlessness and agitation	0.004	0.996	0.000
M48.09 Spinal stenosis (Site unspecified)	0.004	0.996	0.000
Q05 Spina bifida	0.004	0.996	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.004	0.996	0.000
Q12.9 Congenital lens malformation, unspecified	0.003	0.996	0.000
Q12.8 Other congenital lens malformations	0.003	0.996	0.000
Q12.4 Spherophakia	0.003	0.996	0.000
Q12.3 Congenital aphakia	0.003	0.996	0.000
Q12.2 Coloboma of lens	0.003	0.996	0.000
Q12.1 Congenital displaced lens	0.003	0.996	0.000
Q45.9 Congenital malformation of digestive system, unspecified	0.003	0.996	0.000
Q45.2 Congenital pancreatic cyst	0.003	0.996	0.000
Q45.1 Annular pancreas	0.003	0.996	0.000
Q45.0 Agenesis, aplasia and hypoplasia of pancreas	0.003	0.996	0.000
Q07.8 Other specified congenital malformations of nervous system	0.003	0.996	0.000
C18.5 Splenic flexure	0.000	0.996	0.004
C79.3 Secondary malignant neoplasm of brain and cerebral meninges	0.000	0.996	0.004
Q79.6 Ehlers-Danlos syndrome	0.003	0.996	0.000
Q10.7 Congenital malformation of orbit	0.003	0.996	0.000
Q10.6 Other congenital malformations of lachrymal apparatus	0.003	0.996	0.000
Q10.5 Congenital stenosis and stricture of lachrymal duct	0.003	0.996	0.000
Q10.4 Absence and agenesis of lachrymal apparatus	0.003	0.996	0.000
Q10.3 Other congenital malformations of eyelid	0.003	0.996	0.000
Q10.2 Congenital entropion	0.003	0.996	0.000
Q10.1 Congenital ectropion	0.003	0.996	0.000
Q10.0 Congenital ptosis	0.003	0.996	0.000
Q11.3 Macrophthalmos	0.003	0.996	0.000
Q11.2 Microphthalmos	0.003	0.996	0.000
Q11.1 Other anophthalmos	0.003	0.996	0.000
Q11.0 Cystic eyeball	0.003	0.996	0.000
Q13.9 Congenital malformation of anterior segment of eye, unspecified	0.003	0.996	0.000
Q13.8 Other congenital malformations of anterior segment of eye	0.003	0.996	0.000
Q13.5 Blue sclera	0.003	0.996	0.000
Q13.4 Other congenital corneal malformations	0.003	0.996	0.000
Q13.3 Congenital corneal opacity	0.003	0.996	0.000
Q13.2 Other congenital malformations of iris	0.003	0.996	0.000
Q13.1 Absence of iris	0.003	0.996	0.000
Q13.0 Coloboma of iris	0.003	0.996	0.000
Q14.9 Congenital malformation of posterior segment of eye, unspecified	0.003	0.996	0.000
Q14.8 Other congenital malformations of posterior segment of eye	0.003	0.996	0.000
Q14.3 Congenital malformation of choroid	0.003	0.996	0.000
Q14.2 Congenital malformation of optic disk	0.003	0.996	0.000
Q14.1 Congenital malformation of retina	0.003	0.996	0.000
Q14.0 Congenital malformation of vitreous humour	0.003	0.996	0.000
Q16.9 Congenital malformation of ear causing impairment of hearing, unspecified	0.003	0.996	0.000
Q16.5 Congenital malformation of inner ear	0.003	0.996	0.000
Q16.4 Other congenital malformations of middle ear	0.003	0.996	0.000
Q16.3 Congenital malformation of ear ossicles	0.003	0.996	0.000
Q16.2 Absence of eustachian tube	0.003	0.996	0.000
Q16.1 Congenital absence, atresia and stricture of auditory canal (external)	0.003	0.996	0.000
Q16.0 Congenital absence of (ear) auricle	0.003	0.996	0.000
Q27.3 Peripheral arteriovenous malformation	0.003	0.996	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations