TreeWAS – Variant ID: rs4148008

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M25.76 Osteophyte (Lower leg)	0.000	0.785	0.215
M25.7 Osteophyte	0.000	0.810	0.190
M25.77 Osteophyte (Ankle and foot)	0.000	0.821	0.179
M25.72 Osteophyte (Upper arm)	0.000	0.840	0.160
M25.73 Osteophyte (Forearm)	0.000	0.852	0.147
M25.71 Osteophyte (Shoulder region)	0.000	0.853	0.147
M25.78 Osteophyte (Other)	0.000	0.857	0.143
M25.79 Osteophyte (Site unspecified)	0.000	0.858	0.142
M25.70 Osteophyte (Multiple sites)	0.000	0.864	0.136
M25.74 Osteophyte (Hand)	0.000	0.879	0.121
M25.75 Osteophyte (Pelvic region and thigh)	0.000	0.883	0.117
C91.1 Chronic lymphocytic leukaemia	0.044	0.956	0.000
C91 Lymphoid leukaemia	0.040	0.960	0.000
C91.9 Lymphoid leukaemia, unspecified	0.037	0.963	0.000
M54.59 Low back pain (Site unspecified)	0.000	0.964	0.036
C91.4 Hairy-cell leukaemia	0.033	0.967	0.000
C91.5 Adult T-cell leukaemia	0.032	0.968	0.000
C91.0 Acute lymphoblastic leukaemia	0.032	0.968	0.000
C91.8 Mature B-cell leukaemia Burkitt-type	0.029	0.971	0.000
C91.7 Other lymphoid leukaemia	0.029	0.971	0.000
C91.6 Prolymphocytic leukaemia of T-cell type	0.029	0.971	0.000
C91.3 Prolymphocytic leukaemia	0.029	0.971	0.000
C91.2 Subacute lymphocytic leukaemia	0.029	0.971	0.000
I64 Stroke, not specified as haemorrhage or infarction	0.000	0.980	0.020
L53 Other erythematous conditions	0.015	0.985	0.000
L53.9 Erythematous condition, unspecified	0.015	0.985	0.000
L53.8 Other specified erythematous conditions	0.014	0.986	0.000
L50-L54 Urticaria and erythema	0.013	0.987	0.000
L52 Erythema nodosum	0.013	0.987	0.000
L53.0 Toxic erythema	0.013	0.987	0.000
L50.9 Urticaria, unspecified	0.012	0.988	0.000
N43.3 Hydrocele, unspecified	0.012	0.988	0.000
L50 Urticaria	0.012	0.988	0.000
N81.9 Female genital prolapse, unspecified	0.011	0.989	0.000
L53.3 Other chronic figurate erythema	0.011	0.989	0.000
L53.2 Erythema marginatum	0.011	0.989	0.000
L53.1 Erythema annulare centrifugum	0.011	0.989	0.000
C81.1 Nodular sclerosis	0.010	0.990	0.000
C81 Hodgkin's disease	0.010	0.990	0.000
L54 Erythema in diseases classified elsewhere	0.009	0.990	0.000
L51 Erythema multiforme	0.009	0.991	0.000
L50.1 Idiopathic urticaria	0.009	0.991	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.009	0.991	0.000
C81.2 Mixed cellularity	0.009	0.991	0.000
C81.9 Hodgkin's disease, unspecified	0.009	0.991	0.000
L50.6 Contact urticaria	0.008	0.991	0.000
L50.5 Cholinergic urticaria	0.008	0.991	0.000
L50.4 Vibratory urticaria	0.008	0.991	0.000
L50.3 Dermatographic urticaria	0.008	0.991	0.000
L50.2 Urticaria due to cold and heat	0.008	0.991	0.000
L03.9 Cellulitis, unspecified	0.008	0.992	0.000
C88 Malignant immunoproliferative diseases	0.008	0.992	0.000
C84 Peripheral and cutaneous T-cell lymphomas	0.008	0.992	0.000
C81.4 Lymphocyte-rich classical Hodgkin lymphoma	0.007	0.992	0.000
C81.3 Lymphocytic depletion	0.007	0.992	0.000
K92.9 Disease of digestive system, unspecified	0.008	0.992	0.000
C81.7 Other Hodgkin's disease	0.007	0.992	0.000
C81.0 Lymphocytic predominance	0.007	0.992	0.000
K83.8 Other specified diseases of biliary tract	0.007	0.993	0.000
I45.9 Conduction disorder, unspecified	0.007	0.993	0.000
K41.9 Unilateral or unspecified femoral hernia, without obstruction or gangrene	0.000	0.993	0.007
L54.8 Erythema in other diseases classified elsewhere	0.007	0.993	0.000
L54.0 Erythema marginatum in acute rheumatic fever	0.007	0.993	0.000
G90.2 Horner's syndrome	0.000	0.993	0.007
C84.4 Peripheral T-cell lymphoma	0.007	0.993	0.000
L50.8 Other urticaria	0.007	0.993	0.000
C88.4 Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]	0.007	0.993	0.000
I45.3 Trifascicular block	0.007	0.993	0.000
L51.8 Other erythema multiforme	0.007	0.993	0.000
L51.2 Toxic epidermal necrolysis [Lyell]	0.007	0.993	0.000
L51.0 Nonbullous erythema multiforme	0.007	0.993	0.000
L51.9 Erythema multiforme, unspecified	0.007	0.993	0.000
R13 Dysphagia	0.007	0.993	0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.007	0.993	0.000
C94 Other leukaemias of specified cell type	0.007	0.993	0.000
J44.8 Other specified chronic obstructive pulmonary disease	0.000	0.993	0.007
L50.0 Allergic urticaria	0.006	0.993	0.000
L51.1 Bullous erythema multiforme	0.006	0.994	0.000
C86 Other specified types of T/NK-cell lymphoma	0.006	0.994	0.000
C93 Monocytic leukaemia	0.006	0.994	0.000
E05.9 Thyrotoxicosis, unspecified	0.006	0.994	0.000
C88.0 Waldenstrom's macroglobulinaemia	0.006	0.994	0.000
Z50.0 Cardiac rehabilitation	0.000	0.994	0.006
C88.9 Malignant immunoproliferative disease, unspecified	0.006	0.994	0.000
C88.7 Other malignant immunoproliferative diseases	0.006	0.994	0.000
C88.3 Immunoproliferative small intestinal disease	0.006	0.994	0.000
C88.2 Gamma heavy chain disease	0.006	0.994	0.000
C88.1 Alpha heavy chain disease	0.006	0.994	0.000
I45 Other conduction disorders	0.006	0.994	0.000
C84.9 Mature T/NK-cell lymphoma, unspecified	0.006	0.994	0.000
C84.8 Cutaneous T-cell lymphoma, unspecified	0.006	0.994	0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative	0.006	0.994	0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive	0.006	0.994	0.000
C84.3 Lymphoepithelioid lymphoma	0.006	0.994	0.000
C84.2 T-zone lymphoma	0.006	0.994	0.000
C84.1 Sezary's diease	0.006	0.994	0.000
C95 Leukaemia of unspecified cell type	0.006	0.994	0.000
C84.0 Mycosis fungoides	0.005	0.994	0.000
I45.5 Other specified heart block	0.006	0.994	0.000
C84.5 Other and unspecified T-cell lymphomas	0.005	0.995	0.000
K41 Femoral hernia	0.000	0.995	0.005
K41.3 Unilateral or unspecified femoral hernia, with obstruction, without gangrene	0.000	0.995	0.005
C90 Multiple myeloma and malignant plasma cell neoplasms	0.005	0.995	0.000
C94.7 Other specified leukaemias	0.005	0.995	0.000
C94.6 Myelodysplastic and myeloproliferative disease, not elsewhere classified	0.005	0.995	0.000
C94.5 Acute myelofibrosis	0.005	0.995	0.000
C94.4 Acute panmyelosis	0.005	0.995	0.000
C94.3 Mast cell leukaemia	0.005	0.995	0.000
C94.2 Acute megakaryoblastic leukaemia	0.005	0.995	0.000
C94.1 Chronic erythraemia	0.005	0.995	0.000
C94.0 Acute erythraemia and erythroleukaemia	0.005	0.995	0.000
C96.9 Malignant neoplasms of lymphoid, haematopoietic and related tissue, unspecified	0.005	0.995	0.000
C96.8 Histiocytic sarcoma	0.005	0.995	0.000
C96.7 Other specified malignant neoplasms of lymphoid, haematopoietic and related tissue	0.005	0.995	0.000
C96.6 Unifocal Langerhans-cell histiocytosis	0.005	0.995	0.000
C96.5 Multifocal and unisystemic Langerhans-cell histiocytosis	0.005	0.995	0.000
C96.4 Sarcoma of dendritic cells (accessory cells)	0.005	0.995	0.000
C96.3 True histiocytic lymphoma	0.005	0.995	0.000
C96.2 Malignant mast cell tumour	0.005	0.995	0.000
C96.1 Malignant histiocytosis	0.005	0.995	0.000
C96.0 Letterer-Siwe disease	0.005	0.995	0.000
I45.2 Bifascicular block	0.005	0.995	0.000
S92.00 Fracture of calcaneus (closed)	0.005	0.995	0.000
C86.6 Primary cutaneous CD30-positive T-cell proliferations	0.005	0.995	0.000
C86.4 Blastic NK-cell lymphoma	0.005	0.995	0.000
C86.3 Subcutaneous panniculitis-like T-cell lymphoma	0.005	0.995	0.000
C86.2 Enteropathy-type (intestinal) T-cell lymphoma	0.005	0.995	0.000
C86.1 Hepatosplenic T-cell lymphoma	0.005	0.995	0.000
C86.0 Extranodal NK/T-cell lymphoma, nasal type	0.005	0.995	0.000
C93.9 Monocytic leukaemia, unspecified	0.005	0.995	0.000
C93.7 Other monocytic leukaemia	0.005	0.995	0.000
C93.3 Juvenile myelomonocytic leukaemia	0.005	0.995	0.000
C93.2 Subacute monocytic leukaemia	0.005	0.995	0.000
C93.0 Acute monocytic leukaemia	0.005	0.995	0.000
M48.02 Spinal stenosis (Cervical region)	0.000	0.995	0.005
C90.1 Plasma cell leukaemia	0.004	0.995	0.000
N43 Hydrocele and spermatocele	0.004	0.996	0.000
C86.5 Angioimmunoblastic T-cell lymphoma	0.004	0.996	0.000
I45.0 Right fascicular block	0.004	0.996	0.000
C95.7 Other leukaemia of unspecified cell type	0.004	0.996	0.000
C95.2 Subacute leukaemia of unspecified cell type	0.004	0.996	0.000
C93.1 Chronic monocytic leukaemia	0.004	0.996	0.000
C95.1 Chronic leukaemia of unspecified cell type	0.004	0.996	0.000
C95.0 Acute leukaemia of unspecified cell type	0.004	0.996	0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma	0.004	0.996	0.000
K41.4 Unilateral or unspecified femoral hernia, with gangrene	0.000	0.996	0.004
K41.2 Bilateral femoral hernia, without obstruction or gangrene	0.000	0.996	0.004
K41.1 Bilateral femoral hernia, with gangrene	0.000	0.996	0.004
K41.0 Bilateral femoral hernia, with obstruction, without gangrene	0.000	0.996	0.004
C90.2 Plasmacytoma, extramedullary	0.004	0.996	0.000
C83 Diffuse non-Hodgkin's lymphoma	0.004	0.996	0.000
C95.9 Leukaemia, unspecified	0.004	0.996	0.000
C90.3 Solitary plasmacytoma	0.004	0.996	0.000
I45.4 Nonspecific intraventricular block	0.004	0.996	0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type	0.004	0.996	0.000
N43.1 Infected hydrocele	0.003	0.996	0.000
I45.8 Other specified conduction disorders	0.003	0.996	0.000
I45.1 Other and unspecified right bundle-branch block	0.004	0.996	0.000
M19.94 Arthrosis, unspecified (Hand)	0.004	0.996	0.000
D73.0 Hyposplenism	0.004	0.996	0.000
S90.9 Superficial injury of ankle and foot, unspecified	0.003	0.996	0.000
N43.0 Encysted hydrocele	0.003	0.997	0.000
S06.80 Other intracranial injuries (without open intracranial wound)	0.000	0.997	0.003
C92 Myeloid leukaemia	0.003	0.997	0.000
M41.99 Scoliosis, unspecified (Site unspecified)	0.003	0.997	0.000
S92.0 Fracture of calcaneus	0.003	0.997	0.000
M79.00 Rheumatism, unspecified (Multiple sites)	0.003	0.997	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.000	0.997	0.003
N43.4 Spermatocele	0.003	0.997	0.000
C85.2 Mediastinal (thymic) large B-cell lymphoma	0.003	0.997	0.000
C85.0 Lymphosarcoma	0.003	0.997	0.000
N43.2 Other hydrocele	0.003	0.997	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.003	0.997	0.000
S90 Superficial injury of ankle and foot	0.003	0.997	0.000
C83.0 Small cell (diffuse)	0.003	0.997	0.000
J33.0 Polyp of nasal cavity	0.000	0.997	0.003
S90.1 Contusion of toe(s) without damage to nail	0.003	0.997	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.003	0.997	0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.000	0.997	0.003
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.003	0.997	0.000
C83.6 Undifferentiated (diffuse)	0.003	0.997	0.000
C83.5 Lymphoblastic (diffuse)	0.003	0.997	0.000
C83.4 Immunoblastic (diffuse)	0.003	0.997	0.000
C83.2 Mixed small and large cell (diffuse)	0.003	0.997	0.000
C83.9 Diffuse non-Hodgkin's lymphoma, unspecified	0.003	0.997	0.000
C83.1 Small cleaved cell (diffuse)	0.003	0.997	0.000
C92.4 Acute promyelocytic leukaemia	0.003	0.997	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.003	0.997	0.000
S62.00 Fracture of navicular [scaphoid] bone of hand (closed)	0.003	0.997	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.003	0.997	0.000
F11.2 Dependence syndrome	0.003	0.997	0.000
S90.8 Other superficial injuries of ankle and foot	0.003	0.997	0.000
C92.9 Myeloid leukaemia, unspecified	0.003	0.997	0.000
C92.8 Acute myeloid leukaemia with multilineage dysplasia	0.003	0.997	0.000
C92.6 Acute myeloid leukaemia with 11q23-abnormality	0.003	0.997	0.000
C92.3 Myeloid sarcoma	0.003	0.997	0.000
C92.2 Subacute myeloid leukaemia	0.003	0.997	0.000
M45 Ankylosing spondylitis	0.000	0.997	0.003
C92.5 Acute myelomonocytic leukaemia	0.003	0.997	0.000
C83.7 Burkitt's tumour	0.003	0.997	0.000
S92.01 Fracture of calcaneus (open)	0.003	0.997	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.003	0.997	0.000
D56.1 Beta thalassaemia	0.003	0.997	0.000
S90.3 Contusion of other and unspecified parts of foot	0.002	0.997	0.000
S90.7 Multiple superficial injuries of ankle and foot	0.002	0.997	0.000
S90.2 Contusion of toe(s) with damage to nail	0.002	0.997	0.000
Z91.5 Personal history of self-harm	0.000	0.997	0.003
C82.6 Cutaneous follicle centre lymphoma	0.002	0.998	0.000
C82.5 Diffuse follicle centre lymphoma	0.002	0.998	0.000
C82.4 Follicular lymphoma grade IIIb	0.002	0.998	0.000
C92.7 Other myeloid leukaemia	0.002	0.998	0.000
C45.0 Mesothelioma of pleura	0.000	0.998	0.002
C83.8 Other types of diffuse non-Hodgkin's lymphoma	0.002	0.998	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.002	0.998	0.000
M77.91 Enthesopathy, unspecified (Shoulder region)	0.000	0.998	0.002
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.002	0.998	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.002	0.998	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.002	0.998	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.002	0.998	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.002	0.998	0.000
D32.0 Cerebral meninges	0.000	0.998	0.002
C82.0 Small cleaved cell, follicular	0.002	0.998	0.000
D56.9 Thalassaemia, unspecified	0.002	0.998	0.000
D56 Thalassaemia	0.002	0.998	0.000
D56.3 Thalassaemia trait	0.002	0.998	0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)	0.000	0.998	0.002
S90.0 Contusion of ankle	0.002	0.998	0.000
C82.3 Follicular lymphoma grade IIIa	0.002	0.998	0.000
F11.3 Withdrawal state	0.002	0.998	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.000	0.998	0.002
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.000	0.998	0.002
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.000	0.998	0.002
M45.X4 Ankylosing spondylitis (Thoracic region)	0.000	0.998	0.002
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.000	0.998	0.002
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.000	0.998	0.002
I45.6 Preexcitation syndrome	0.002	0.998	0.000
Z56.0 Unemployment, unspecified	0.000	0.998	0.002
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.002	0.998	0.000
S92 Fracture of foot, except ankle	0.002	0.998	0.000
Y83.0 Surgical operation with transplant of whole organ	0.000	0.998	0.002
S90-S99 Injuries to the ankle and foot	0.002	0.998	0.000
S02.20 Fracture of nasal bones (closed)	0.000	0.998	0.002
M45.X2 Ankylosing spondylitis (Cervical region)	0.000	0.998	0.002
F11 Mental and behavioural disorders due to use of opioids	0.002	0.998	0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.002	0.998	0.000
C85.7 Other specified types of non-Hodgkin's lymphoma	0.002	0.998	0.000
M45.X6 Ankylosing spondylitis (Lumbar region)	0.000	0.998	0.002
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.002	0.998	0.000
S06.8 Other intracranial injuries	0.000	0.998	0.002
S99 Other and unspecified injuries of ankle and foot	0.002	0.998	0.000
N64.8 Other specified disorders of breast	0.002	0.998	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.002	0.998	0.000
F11.1 Harmful use	0.002	0.998	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.002	0.998	0.000
D73 Diseases of spleen	0.002	0.998	0.000
D56.8 Other thalassaemias	0.002	0.998	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.002	0.998	0.000
D56.2 Delta-beta thalassaemia	0.002	0.998	0.000
D56.0 Alpha thalassaemia	0.002	0.998	0.000
C82.2 Large cell, follicular	0.001	0.998	0.001
M46.9 Inflammatory spondylopathy, unspecified	0.000	0.998	0.002
M54.64 Pain in thoracic spine (Thoracic region)	0.002	0.998	0.000
S97 Crushing injury of ankle and foot	0.002	0.998	0.000
S99.8 Other specified injuries of ankle and foot	0.002	0.998	0.000
S39.9 Unspecified injury of abdomen, lower back and pelvis	0.002	0.998	0.000
S93.3 Dislocation of other and unspecified parts of foot	0.002	0.998	0.000
S93.1 Dislocation of toe(s)	0.002	0.998	0.000
S99.9 Unspecified injury of ankle and foot	0.002	0.998	0.000
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)	0.000	0.998	0.002
M81.20 Osteoporosis of disuse (Multiple sites)	0.002	0.998	0.000
S92.9 Fracture of foot, unspecified	0.002	0.998	0.000
S92.4 Fracture of great toe	0.002	0.998	0.000
D73.1 Hypersplenism	0.002	0.998	0.000
K27.9 Unspecified as acute or chronic, without haemorrhage or perforation	0.002	0.998	0.000
R47.1 Dysarthria and anarthria	0.000	0.998	0.002
S98 Traumatic amputation of ankle and foot	0.002	0.998	0.000
S95 Injury of blood vessels at ankle and foot level	0.002	0.998	0.000
S94 Injury of nerves at ankle and foot level	0.002	0.998	0.000
D73.4 Cyst of spleen	0.002	0.998	0.000
F11.9 Unspecified mental and behavioural disorder	0.002	0.998	0.000
F11.8 Other mental and behavioural disorders	0.002	0.998	0.000
F11.7 Residual and late-onset psychotic disorder	0.002	0.998	0.000
F11.6 Amnesic syndrome	0.002	0.998	0.000
F11.5 Psychotic disorder	0.002	0.998	0.000
F11.4 Withdrawal state with delirium	0.002	0.998	0.000
F11.0 Acute intoxication	0.002	0.998	0.000
S92.5 Fracture of other toe	0.002	0.998	0.000
S06.81 Other intracranial injuries (with open intracranial wound)	0.000	0.998	0.002
D73.5 Infarction of spleen	0.002	0.998	0.000
S99.7 Multiple injuries of ankle and foot	0.002	0.998	0.000
C45 Mesothelioma	0.000	0.998	0.002
G90 Disorders of autonomic nervous system	0.000	0.998	0.002
H44.0 Purulent endophthalmitis	0.002	0.998	0.000
S00.0 Superficial injury of scalp	0.000	0.998	0.002
S93.4 Sprain and strain of ankle	0.002	0.998	0.000
S93.6 Sprain and strain of other and unspecified parts of foot	0.002	0.998	0.000
S93.5 Sprain and strain of toe(s)	0.002	0.998	0.000
S93.2 Rupture of ligaments at ankle and foot level	0.002	0.998	0.000
C45.9 Mesothelioma, unspecified	0.000	0.998	0.002
S97.8 Crushing injury of other parts of ankle and foot	0.002	0.998	0.000
D73.8 Other diseases of spleen	0.002	0.998	0.000
M77.97 Enthesopathy, unspecified (Ankle and foot)	0.000	0.998	0.002
C85.1 B-cell lymphoma, unspecified	0.002	0.998	0.000
D73.2 Chronic congestive splenomegaly	0.002	0.998	0.000
S92.7 Multiple fractures of foot	0.002	0.998	0.000
S96 Injury of muscle and tendon at ankle and foot level	0.002	0.998	0.000
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)	0.000	0.998	0.002
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)	0.000	0.998	0.002
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)	0.000	0.998	0.002
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)	0.000	0.998	0.002
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)	0.000	0.998	0.002
S93.0 Dislocation of ankle joint	0.002	0.998	0.000
S97.1 Crushing injury of toe(s)	0.001	0.998	0.000
S97.0 Crushing injury of ankle	0.001	0.998	0.000
S92.1 Fracture of talus	0.001	0.998	0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.000	0.998	0.002
C83.3 Large cell (diffuse)	0.002	0.998	0.000
M79.0 Rheumatism, unspecified	0.002	0.998	0.000
S92.2 Fracture of other tarsal bone(s)	0.001	0.998	0.000
S92.91 Fracture of foot, unspecified (open)	0.001	0.998	0.000
S92.90 Fracture of foot, unspecified (closed)	0.001	0.998	0.000
B18.2 Chronic viral hepatitis C	0.002	0.998	0.000
D73.9 Disease of spleen, unspecified	0.001	0.998	0.000
S92.40 Fracture of great toe (closed)	0.001	0.998	0.000
C92.1 Chronic myeloid leukaemia	0.001	0.998	0.000
S94.9 Injury of unspecified nerve at ankle and foot level	0.001	0.998	0.000
S94.8 Injury of other nerves at ankle and foot level	0.001	0.998	0.000
S94.7 Injury of multiple nerves at ankle and foot level	0.001	0.998	0.000
S94.3 Injury of cutaneous sensory nerve at ankle and foot level	0.001	0.998	0.000
S94.2 Injury of deep peroneal nerve at ankle and foot level	0.001	0.998	0.000
S94.1 Injury of medial plantar nerve	0.001	0.998	0.000
S94.0 Injury of lateral plantar nerve	0.001	0.998	0.000
S95.9 Injury of unspecified blood vessel at ankle and foot level	0.001	0.998	0.000
S95.8 Injury of other blood vessels at ankle and foot level	0.001	0.998	0.000
S95.7 Injury of multiple blood vessels at ankle and foot level	0.001	0.998	0.000
S95.2 Injury of dorsal vein of foot	0.001	0.998	0.000
S95.1 Injury of plantar artery of foot	0.001	0.998	0.000
S95.0 Injury of dorsal artery of foot	0.001	0.998	0.000
S98.4 Traumatic amputation of foot, level unspecified	0.001	0.998	0.000
S98.3 Traumatic amputation of other parts of foot	0.001	0.998	0.000
S98.2 Traumatic amputation of two or more toes	0.001	0.998	0.000
S98.1 Traumatic amputation of one toe	0.001	0.998	0.000
S98.0 Traumatic amputation of foot at ankle level	0.001	0.998	0.000
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.000	0.998	0.001
S92.50 Fracture of other toe (closed)	0.001	0.998	0.000
G90.0 Idiopathic peripheral autonomic neuropathy	0.000	0.998	0.001
K45.8 Other specified abdominal hernia without obstruction or gangrene	0.000	0.998	0.002
T43.5 Other and unspecified antipsychotics and neuroleptics	0.000	0.998	0.002
D73.3 Abscess of spleen	0.001	0.998	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.002	0.998	0.000
M05 Seropositive rheumatoid arthritis	0.002	0.998	0.000
S92.41 Fracture of great toe (open)	0.001	0.998	0.000
C45.2 Mesothelioma of pericardium	0.000	0.998	0.001
C45.1 Mesothelioma of peritoneum	0.000	0.998	0.001
E87.3 Alkalosis	0.000	0.998	0.002
S96.1 Injury of muscle and tendon of long extensor muscle of toe at ankle and foot level	0.001	0.998	0.000
M00.94 Pyogenic arthritis, unspecified (Hand)	0.000	0.998	0.001
M79.01 Rheumatism, unspecified (Shoulder region)	0.001	0.998	0.000
S93.40 Sprain of unspecified ligament of ankle	0.001	0.998	0.000
G90.8 Other disorders of autonomic nervous system	0.000	0.998	0.001
G90.4 Autonomic dysreflexia	0.000	0.998	0.001
G90.1 Familial dysautonomia [Riley-Day]	0.000	0.998	0.001
S02.2 Fracture of nasal bones	0.000	0.998	0.002
S31.4 Open wound of vagina and vulva	0.001	0.998	0.000
M67.2 Synovial hypertrophy, not elsewhere classified	0.001	0.998	0.000
M79.09 Rheumatism, unspecified (Site unspecified)	0.002	0.998	0.000
S92.71 Multiple fractures of foot (open)	0.001	0.998	0.000
I97.1 Other functional disturbances following cardiac surgery	0.001	0.998	0.000
S96.7 Injury of multiple muscles and tendons at ankle and foot level	0.001	0.998	0.000
S96.2 Injury of intrinsic muscle and tendon at ankle and foot level	0.001	0.998	0.000
S96.0 Injury of muscle and tendon of long flexor muscle of toe at ankle and foot level	0.001	0.998	0.000
M46 Other inflammatory spondylopathies	0.000	0.998	0.001
C92.0 Acute myeloid leukaemia	0.001	0.999	0.000
D12.2 Ascending colon	0.000	0.999	0.001
S92.3 Fracture of metatarsal bone	0.001	0.999	0.000
M46.18 Sacroiliitis, not elsewhere classified-Sacral/sacrococ	0.000	0.999	0.001
S02.70 Multiple fractures involving skull and facial bones (closed)	0.000	0.999	0.001
S92.51 Fracture of other toe (open)	0.001	0.999	0.000
M46.0 Spinal enthesopathy	0.000	0.999	0.001
S01.3 Open wound of ear	0.000	0.999	0.001
M46.06 Spinal enthesopathy (Lumbar region)	0.000	0.999	0.001
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.000	0.999	0.001
S92.11 Fracture of talus (open)	0.001	0.999	0.000
G54.9 Nerve root and plexus disorder, unspecified	0.000	0.999	0.001
I70.21 Atherosclerosis of arteries of extremities (with gangrene)	0.001	0.999	0.000
M79.07 Rheumatism, unspecified (Ankle and foot)	0.001	0.999	0.000
M79.06 Rheumatism, unspecified (Lower leg)	0.001	0.999	0.000
M79.05 Rheumatism, unspecified (Pelvic region and thigh)	0.001	0.999	0.000
M79.04 Rheumatism, unspecified (Hand)	0.001	0.999	0.000
M79.03 Rheumatism, unspecified (Forearm)	0.001	0.999	0.000
M79.02 Rheumatism, unspecified (Upper arm)	0.001	0.999	0.000
S92.21 Fracture of other tarsal bone(s) (open)	0.001	0.999	0.000
D12.4 Descending colon	0.000	0.999	0.001
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.001	0.999	0.000
M05.8 Other seropositive rheumatoid arthritis	0.001	0.999	0.000
M05.2 Rheumatoid vasculitis	0.001	0.999	0.000
O36.5 Maternal care for poor foetal growth	0.000	0.999	0.001
R40.0 Somnolence	0.000	0.999	0.001
S96.8 Injury of other muscles and tendons at ankle and foot level	0.001	0.999	0.000
M54.29 Cervicalgia-Site unspe	0.001	0.999	0.000
C45.7 Mesothelioma of other sites	0.000	0.999	0.001
M46.1 Sacro-iliitis, not elsewhere classified	0.000	0.999	0.001
M54.5 Low back pain	0.000	0.999	0.001
Q28.2 Arteriovenous malformation of cerebral vessels	0.001	0.999	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.001	0.999	0.000
M05.1 Rheumatoid lung disease	0.001	0.999	0.000
M05.0 Felty's syndrome	0.001	0.999	0.000
S02.21 Fracture of nasal bones (open)	0.000	0.999	0.001
S96.9 Injury of unspecified muscle and tendon at ankle and foot level	0.001	0.999	0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.001	0.999	0.000
M46.8 Other specified inflammatory spondylopathies	0.000	0.999	0.001
M46.5 Other infective spondylopathies	0.000	0.999	0.001
M46.3 Infection of intervertebral disk (pyogenic)	0.000	0.999	0.001
S62.0 Fracture of navicular [scaphoid] bone of hand	0.001	0.999	0.000
M05.29 Rheumatoid vasculitis (Site unspecified)	0.001	0.999	0.000
S92.31 Fracture of metatarsal bone (open)	0.001	0.999	0.000
M77.9 Enthesopathy, unspecified	0.000	0.999	0.001
N26 Unspecified contracted kidney	0.000	0.999	0.001
M46.09 Spinal enthesopathy (Site unspecified)	0.000	0.999	0.001
M46.08 Spinal enthesopathy (Sacral and sacrococcygeal region)	0.000	0.999	0.001
M46.07 Spinal enthesopathy (Lumbosacral region)	0.000	0.999	0.001
M46.05 Spinal enthesopathy (Thoracolumbar region)	0.000	0.999	0.001
M46.04 Spinal enthesopathy (Thoracic region)	0.000	0.999	0.001
M46.03 Spinal enthesopathy (Cervicothoracic region)	0.000	0.999	0.001
M46.02 Spinal enthesopathy (Cervical region)	0.000	0.999	0.001
M46.01 Spinal enthesopathy (Occipito-atlanto-axial region)	0.000	0.999	0.001
M46.00 Spinal enthesopathy (Multiple sites in spine)	0.000	0.999	0.001
B25.9 Cytomegaloviral disease, unspecified	0.001	0.999	0.000
Z80.5 Family history of malignant neoplasm of urinary tract	0.000	0.999	0.001
M00.96 Pyogenic arthritis, unspecified (Lower leg)	0.000	0.999	0.001
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.001	0.999	0.000
M05.88 Other seropositive rheumatoid arthritis (Other)	0.001	0.999	0.000
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.001	0.999	0.000
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.001	0.999	0.000
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.001	0.999	0.000
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.001	0.999	0.000
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.001	0.999	0.000
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.001	0.999	0.000
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.001	0.999	0.000
M46.36 Infection of intervertebral disc (pyogenic) (Lumbar region)	0.000	0.999	0.001
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)	0.000	0.999	0.001
S92.70 Multiple fractures of foot (closed)	0.001	0.999	0.000
M05.28 Rheumatoid vasculitis (Other)	0.001	0.999	0.000
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.001	0.999	0.000
M05.26 Rheumatoid vasculitis (Lower leg)	0.001	0.999	0.000
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.001	0.999	0.000
M05.24 Rheumatoid vasculitis (Hand)	0.001	0.999	0.000
M05.23 Rheumatoid vasculitis (Forearm)	0.001	0.999	0.000
M05.22 Rheumatoid vasculitis (Upper arm)	0.001	0.999	0.000
M05.21 Rheumatoid vasculitis (Shoulder region)	0.001	0.999	0.000
M05.20 Rheumatoid vasculitis (Multiple sites)	0.001	0.999	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.001	0.999	0.000
C49.1 Connective and soft tissue of upper limb, including shoulder	0.000	0.999	0.001
F50.0 Anorexia nervosa	0.001	0.999	0.000
M00.91 Pyogenic arthritis, unspecified (Shoulder region)	0.000	0.999	0.001
M05.09 Felty's syndrome (Site unspecified)	0.001	0.999	0.000
M05.08 Felty's syndrome (Other)	0.001	0.999	0.000
M05.07 Felty's syndrome (Ankle and foot)	0.001	0.999	0.000
M05.06 Felty's syndrome (Lower leg)	0.001	0.999	0.000
M05.05 Felty's syndrome (Pelvic region and thigh)	0.001	0.999	0.000
M05.04 Felty's syndrome (Hand)	0.001	0.999	0.000
M05.03 Felty's syndrome (Forearm)	0.001	0.999	0.000
M05.02 Felty's syndrome (Upper arm)	0.001	0.999	0.000
M05.01 Felty's syndrome (Shoulder region)	0.001	0.999	0.000
M05.00 Felty's syndrome (Multiple sites)	0.001	0.999	0.000
M05.19 Rheumatoid lung disease (Site unspecified)	0.001	0.999	0.000
M05.18 Rheumatoid lung disease (Other)	0.001	0.999	0.000
M05.17 Rheumatoid lung disease (Ankle and foot)	0.001	0.999	0.000
M05.16 Rheumatoid lung disease (Lower leg)	0.001	0.999	0.000
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.001	0.999	0.000
M05.14 Rheumatoid lung disease (Hand)	0.001	0.999	0.000
M05.13 Rheumatoid lung disease (Forearm)	0.001	0.999	0.000
M05.12 Rheumatoid lung disease (Upper arm)	0.001	0.999	0.000
M05.11 Rheumatoid lung disease (Shoulder region)	0.001	0.999	0.000
M05.10 Rheumatoid lung disease (Multiple sites)	0.001	0.999	0.000
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.001	0.999	0.000
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.001	0.999	0.000
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.001	0.999	0.000
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.001	0.999	0.000
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.001	0.999	0.000
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.001	0.999	0.000
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.001	0.999	0.000
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.001	0.999	0.000
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.001	0.999	0.000
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.001	0.999	0.000
M46.19 Sacroiliitis, not elsewhere classified-Site unspe	0.000	0.999	0.001
M46.16 Sacroiliitis, not elsewhere classified-Lumbar	0.000	0.999	0.001
M46.15 Sacroiliitis, not elsewhere classified-Thoracolumbar	0.000	0.999	0.001
M46.14 Sacroiliitis, not elsewhere classified-Thoracic	0.000	0.999	0.001
M46.13 Sacroiliitis, not elsewhere classified-Cervicothoracic	0.000	0.999	0.001
M46.12 Sacroiliitis, not elsewhere classified-Cervical	0.000	0.999	0.001
M46.11 Sacroiliitis, not elsewhere classified-Occipit-atl-axl	0.000	0.999	0.001
M46.10 Sacroiliitis, not elsewhere classified-Mult site	0.000	0.999	0.001
M48.09 Spinal stenosis (Site unspecified)	0.000	0.999	0.001
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.000	0.999	0.001
M54.57 Low back pain (Lumbosacral region)	0.000	0.999	0.001
M54.53 Low back pain-Cervicothoracic	0.000	0.999	0.001
M54.52 Low back pain-Cervical	0.000	0.999	0.001
M54.51 Low back pain-Occipit-atl-axl	0.000	0.999	0.001
O10.0 Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations