TreeWAS – Variant ID: rs4273077

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
O70.1 Second degree perineal laceration during delivery	0.024	0.976	0.000
O70 Perineal laceration during delivery	0.024	0.976	0.000
T39.1 4-Aminophenol derivatives	0.022	0.978	0.000
O70.9 Perineal laceration during delivery, unspecified	0.021	0.979	0.000
O70.0 First degree perineal laceration during delivery	0.021	0.979	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.020	0.980	0.000
O70.2 Third degree perineal laceration during delivery	0.020	0.980	0.000
T42.4 Benzodiazepines	0.020	0.980	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.020	0.980	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.019	0.981	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.018	0.982	0.000
T39.0 Salicylates	0.017	0.983	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.017	0.983	0.000
O70.3 Fourth degree perineal laceration during delivery	0.017	0.983	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.016	0.984	0.000
O60-O75 Complications of labour and delivery	0.016	0.984	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.016	0.984	0.000
O63 Long labour	0.015	0.985	0.000
T42.0 Hydantoin derivatives	0.015	0.985	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.015	0.985	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.015	0.985	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.015	0.985	0.000
T39.4 Antirheumatics, not elsewhere classified	0.015	0.985	0.000
T39.2 Pyrazolone derivatives	0.015	0.985	0.000
T36 Poisoning by systemic antibiotics	0.014	0.985	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.014	0.986	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.014	0.986	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.014	0.986	0.000
T42.3 Barbiturates	0.014	0.986	0.000
T42.2 Succinimides and oxazolidinediones	0.014	0.986	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.014	0.986	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.014	0.986	0.000
O63.0 Prolonged first stage (of labour)	0.014	0.986	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.014	0.986	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.014	0.986	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.014	0.986	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.014	0.986	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.014	0.986	0.000
O75.2 Pyrexia during labour, not elsewhere classified	0.013	0.986	0.000
O73 Retained placenta and membranes, without haemorrhage	0.013	0.987	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.013	0.987	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.013	0.987	0.000
T50.8 Diagnostic agents	0.013	0.987	0.000
T50.7 Analeptics and opioid receptor antagonists	0.013	0.987	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.013	0.987	0.000
T50.5 Appetite depressants	0.013	0.987	0.000
T50.4 Drugs affecting uric acid metabolism	0.013	0.987	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.013	0.987	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.013	0.987	0.000
T50.1 Loop [high-ceiling] diuretics	0.013	0.987	0.000
T50.0 Mineralocorticoids and their antagonists	0.013	0.987	0.000
O71 Other obstetric trauma	0.013	0.987	0.000
O63.1 Prolonged second stage (of labour)	0.013	0.987	0.000
T42.1 Iminostilbenes	0.012	0.987	0.000
O63.9 Long labour, unspecified	0.012	0.988	0.000
O61 Failed induction of labour	0.012	0.988	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.012	0.988	0.000
O62 Abnormalities of forces of labour	0.012	0.988	0.000
O75.0 Maternal distress during labour and delivery	0.012	0.988	0.000
O74 Complications of anaesthesia during labour and delivery	0.011	0.988	0.000
O65 Obstructed labour due to maternal pelvic abnormality	0.011	0.988	0.000
O60 Preterm delivery	0.011	0.988	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.011	0.988	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.011	0.988	0.000
T45.5 Anticoagulants	0.011	0.988	0.000
O64 Obstructed labour due to malposition and malpresentation of foetus	0.011	0.989	0.000
T36.0 Penicillins	0.011	0.989	0.000
O73.0 Retained placenta, without haemorrhage	0.011	0.989	0.000
O63.2 Delayed delivery of second twin, triplet, etc.	0.011	0.989	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.011	0.989	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.011	0.989	0.000
T45.0 Antiallergic and antiemetic drugs	0.011	0.989	0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.011	0.989	0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid	0.011	0.989	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.011	0.989	0.000
T45.9 Primarily systemic and haematological agent, unspecified	0.011	0.989	0.000
T45.8 Other primarily systemic and haematological agents	0.011	0.989	0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.011	0.989	0.000
T45.6 Fibrinolysis-affecting drugs	0.011	0.989	0.000
T45.4 Iron and its compounds	0.011	0.989	0.000
T45.3 Enzymes, not elsewhere classified	0.011	0.989	0.000
T45.2 Vitamins, not elsewhere classified	0.011	0.989	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.011	0.989	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.011	0.989	0.000
T47.7 Emetics	0.011	0.989	0.000
T47.6 Antidiarrhoeal drugs	0.011	0.989	0.000
T47.5 Digestants	0.011	0.989	0.000
T47.4 Other laxatives	0.011	0.989	0.000
T47.3 Saline and osmotic laxatives	0.011	0.989	0.000
T47.2 Stimulant laxatives	0.011	0.989	0.000
T47.0 Histamine H(2)-receptor antagonists	0.011	0.989	0.000
T36.9 Systemic antibiotic, unspecified	0.011	0.989	0.000
T36.8 Other systemic antibiotics	0.011	0.989	0.000
T36.7 Antifungal antibiotics, systemically used	0.011	0.989	0.000
T36.6 Rifamycins	0.011	0.989	0.000
T36.5 Aminoglycosides	0.011	0.989	0.000
T36.4 Tetracyclines	0.011	0.989	0.000
T36.3 Macrolides	0.011	0.989	0.000
T36.2 Chloramphenicol group	0.011	0.989	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.011	0.989	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.011	0.989	0.000
T43.9 Psychotropic drug, unspecified	0.010	0.989	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.010	0.989	0.000
T43.6 Psychostimulants with abuse potential	0.010	0.989	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.010	0.989	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.010	0.989	0.000
O71.7 Obstetric haematoma of pelvis	0.010	0.989	0.000
O75.9 Complication of labour and delivery, unspecified	0.010	0.989	0.000
O75.5 Delayed delivery after artificial rupture of membranes	0.010	0.989	0.000
O75.4 Other complications of obstetric surgery and procedures	0.010	0.989	0.000
O75.3 Other infection during labour	0.010	0.989	0.000
O75.1 Shock during or following labour and delivery	0.010	0.989	0.000
O71.4 Obstetric high vaginal laceration alone	0.010	0.990	0.000
O61.1 Failed instrumental induction of labour	0.010	0.990	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.010	0.990	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.010	0.990	0.000
T37.5 Antiviral drugs	0.010	0.990	0.000
T37.4 Anthelminthics	0.010	0.990	0.000
T37.3 Other antiprotozoal drugs	0.010	0.990	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.010	0.990	0.000
T37.1 Antimycobacterial drugs	0.010	0.990	0.000
T37.0 Sulphonamides	0.010	0.990	0.000
T41.5 Therapeutic gases	0.010	0.990	0.000
T41.4 Anaesthetic, unspecified	0.010	0.990	0.000
T41.3 Local anaesthetics	0.010	0.990	0.000
T41.2 Other and unspecified general anaesthetics	0.010	0.990	0.000
T41.1 Intravenous anaesthetics	0.010	0.990	0.000
T41.0 Inhaled anaesthetics	0.010	0.990	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.010	0.990	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.010	0.990	0.000
T48.5 Anti-common-cold drugs	0.010	0.990	0.000
T48.4 Expectorants	0.010	0.990	0.000
T48.3 Antitussives	0.010	0.990	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.010	0.990	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.010	0.990	0.000
T48.0 Oxytocic drugs	0.010	0.990	0.000
T49.9 Topical agent, unspecified	0.010	0.990	0.000
T49.8 Other topical agents	0.010	0.990	0.000
T49.7 Dental drugs, topically applied	0.010	0.990	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.010	0.990	0.000
T49.5 Ophthalmological drugs and preparations	0.010	0.990	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.010	0.990	0.000
T49.3 Emollients, demulcents and protectants	0.010	0.990	0.000
T49.2 Local astringents and local detergents	0.010	0.990	0.000
T49.1 Antipruritics	0.010	0.990	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.010	0.990	0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified	0.000	0.990	0.010
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.010	0.990	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.010	0.990	0.000
T46.7 Peripheral vasodilators	0.010	0.990	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.010	0.990	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.010	0.990	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.010	0.990	0.000
T46.1 Calcium-channel blockers	0.010	0.990	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.010	0.990	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.010	0.990	0.000
O73.1 Retained portions of placenta and membranes, without haemorrhage	0.010	0.990	0.000
O62.4 Hypertonic, incoordinate and prolonged uterine contractions	0.010	0.990	0.000
T38.9 Other and unspecified hormone antagonists	0.009	0.990	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.009	0.990	0.000
T38.7 Androgens and anabolic congeners	0.009	0.990	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.009	0.990	0.000
T38.5 Other oestrogens and progestogens	0.009	0.990	0.000
T38.4 Oral contraceptives	0.009	0.990	0.000
T38.2 Antithyroid drugs	0.009	0.990	0.000
T38.1 Thyroid hormones and substitutes	0.009	0.990	0.000
T38.0 Glucocorticoids and synthetic analogues	0.009	0.990	0.000
T40.4 Other synthetic narcotics	0.010	0.990	0.000
O71.9 Obstetric trauma, unspecified	0.009	0.990	0.000
O71.6 Obstetric damage to pelvic joints and ligaments	0.009	0.990	0.000
O71.5 Other obstetric injury to pelvic organs	0.009	0.990	0.000
O71.3 Obstetric laceration of cervix	0.009	0.990	0.000
O71.2 Postpartum inversion of uterus	0.009	0.990	0.000
O71.1 Rupture of uterus during labour	0.009	0.990	0.000
O71.0 Rupture of uterus before onset of labour	0.009	0.990	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.009	0.990	0.000
O64.1 Obstructed labour due to breech presentation	0.009	0.990	0.000
O75.7 Vaginal delivery following previous Caesarean section	0.009	0.991	0.000
O66 Other obstructed labour	0.009	0.991	0.000
O68 Labour and delivery complicated by foetal stress [distress]	0.009	0.991	0.000
O62.3 Precipitate labour	0.009	0.991	0.000
O61.9 Failed induction of labour, unspecified	0.009	0.991	0.000
O61.8 Other failed induction of labour	0.009	0.991	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.009	0.991	0.000
T40.8 Lysergide [LSD]	0.009	0.991	0.000
T40.7 Cannabis (derivatives)	0.009	0.991	0.000
T40.5 Cocaine	0.009	0.991	0.000
T40.3 Methadone	0.009	0.991	0.000
T40.1 Heroin	0.009	0.991	0.000
T40.0 Opium	0.009	0.991	0.000
O71.8 Other specified obstetric trauma	0.009	0.991	0.000
O75.8 Other specified complications of labour and delivery	0.009	0.991	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.009	0.991	0.000
O62.1 Secondary uterine inertia	0.009	0.991	0.000
O62.9 Abnormality of forces of labour, unspecified	0.008	0.991	0.000
O62.8 Other abnormalities of forces of labour	0.008	0.991	0.000
O60.3 Preterm delivery without spontaneous labour	0.008	0.991	0.000
O60.2 Preterm spontaneous labour with term delivery	0.008	0.991	0.000
O60.1 Preterm spontaneous labour with preterm delivery	0.008	0.991	0.000
O60.0 Preterm labour without delivery	0.008	0.991	0.000
O65.9 Obstructed labour due to maternal pelvic abnormality, unspecified	0.008	0.991	0.000
O65.8 Obstructed labour due to other maternal pelvic abnormalities	0.008	0.991	0.000
O65.5 Obstructed labour due to abnormality of maternal pelvic organs	0.008	0.991	0.000
O65.4 Obstructed labour due to foetopelvic disproportion, unspecified	0.008	0.991	0.000
O65.3 Obstructed labour due to pelvic outlet and midcavity contraction	0.008	0.991	0.000
O65.2 Obstructed labour due to pelvic inlet contraction	0.008	0.991	0.000
O65.1 Obstructed labour due to generally contracted pelvis	0.008	0.991	0.000
O65.0 Obstructed labour due to deformed pelvis	0.008	0.991	0.000
O74.9 Complication of anaesthesia during labour and delivery, unspecified	0.008	0.991	0.000
O74.8 Other complications of anaesthesia during labour and delivery	0.008	0.991	0.000
O74.7 Failed or difficult intubation during labour and delivery	0.008	0.991	0.000
O74.6 Other complications of spinal and epidural anaesthesia during labour and delivery	0.008	0.991	0.000
O74.5 Spinal and epidural anaesthesia-induced headache during labour and delivery	0.008	0.991	0.000
O74.4 Toxic reaction to local anaesthesia during labour and delivery	0.008	0.991	0.000
O74.3 Central nervous system complications of anaesthesia during labour and delivery	0.008	0.991	0.000
O74.2 Cardiac complications of anaesthesia during labour and delivery	0.008	0.991	0.000
O74.1 Other pulmonary complications of anaesthesia during labour and delivery	0.008	0.991	0.000
O74.0 Aspiration pneumonitis due to anaesthesia during labour and delivery	0.008	0.991	0.000
O61.0 Failed medical induction of labour	0.008	0.991	0.000
O64.9 Obstructed labour due to malposition and malpresentation, unspecified	0.008	0.992	0.000
O64.8 Obstructed labour due to other malposition and malpresentation	0.008	0.992	0.000
O64.5 Obstructed labour due to compound presentation	0.008	0.992	0.000
O64.4 Obstructed labour due to shoulder presentation	0.008	0.992	0.000
O64.3 Obstructed labour due to brow presentation	0.008	0.992	0.000
O64.2 Obstructed labour due to face presentation	0.008	0.992	0.000
T40.6 Other and unspecified narcotics	0.008	0.992	0.000
I63.9 Cerebral infarction, unspecified	0.008	0.992	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.008	0.992	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.008	0.992	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.008	0.992	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.008	0.992	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.008	0.992	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.008	0.992	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.008	0.992	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.008	0.992	0.000
T44.0 Anticholinesterase agents	0.008	0.992	0.000
O62.2 Other uterine inertia	0.008	0.992	0.000
O72 Postpartum haemorrhage	0.008	0.992	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.008	0.992	0.000
T40.2 Other opioids	0.008	0.992	0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow	0.000	0.992	0.008
O67.8 Other intrapartum haemorrhage	0.007	0.993	0.000
O67.0 Intrapartum haemorrhage with coagulation defect	0.007	0.993	0.000
N80.0 Endometriosis of uterus	0.000	0.993	0.007
O66.9 Obstructed labour, unspecified	0.007	0.993	0.000
O66.8 Other specified obstructed labour	0.007	0.993	0.000
O66.4 Failed trial of labour, unspecified	0.007	0.993	0.000
O66.3 Obstructed labour due to other abnormalities of foetus	0.007	0.993	0.000
O66.2 Obstructed labour due to unusually large foetus	0.007	0.993	0.000
O66.1 Obstructed labour due to locked twins	0.007	0.993	0.000
O62.0 Primary inadequate contractions	0.007	0.993	0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.007	0.993	0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head	0.007	0.993	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.006	0.994	0.000
M35.3 Polymyalgia rheumatica	0.006	0.994	0.000
O72.0 Third-stage haemorrhage	0.006	0.994	0.000
O66.0 Obstructed labour due to shoulder dystocia	0.006	0.994	0.000
L85.8 Other specified epidermal thickening	0.000	0.994	0.006
O67.9 Intrapartum haemorrhage, unspecified	0.006	0.994	0.000
O72.3 Postpartum coagulation defects	0.006	0.994	0.000
O69.9 Labour and delivery complicated by cord complication, unspecified	0.006	0.994	0.000
O69.5 Labour and delivery complicated by vascular lesion of cord	0.006	0.994	0.000
O69.4 Labour and delivery complicated by vasa praevia	0.006	0.994	0.000
O69.3 Labour and delivery complicated by short cord	0.006	0.994	0.000
O69.0 Labour and delivery complicated by prolapse of cord	0.006	0.994	0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.006	0.994	0.000
O47.1 False labour at or after 37 completed weeks of gestation	0.006	0.994	0.000
O69.1 Labour and delivery complicated by cord around neck, with compression	0.005	0.995	0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.005	0.995	0.000
M35.0 Sicca syndrome [Sjogren]	0.005	0.995	0.000
O72.2 Delayed and secondary postpartum haemorrhage	0.005	0.995	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.004	0.995	0.001
T43.2 Other and unspecified antidepressants	0.005	0.995	0.000
L82 Seborrhoeic keratosis	0.000	0.995	0.005
M35 Other systemic involvement of connective tissue	0.005	0.995	0.000
O69.8 Labour and delivery complicated by other cord complications	0.005	0.995	0.000
B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters	0.000	0.996	0.004
O69.2 Labour and delivery complicated by other cord entanglement	0.004	0.996	0.000
N13.3 Other and unspecified hydronephrosis	0.004	0.996	0.000
M35.1 Other overlap syndromes	0.004	0.996	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.004	0.996	0.000
M35.8 Other specified systemic involvement of connective tissue	0.004	0.996	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.004	0.996	0.000
M35.5 Multifocal fibrosclerosis	0.004	0.996	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.004	0.996	0.000
M35.2 Behcet's disease	0.004	0.996	0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly	0.004	0.996	0.000
M35.7 Hypermobility syndrome	0.004	0.996	0.000
R12 Heartburn	0.004	0.996	0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress	0.003	0.996	0.000
O20.0 Threatened abortion	0.000	0.997	0.003
L85 Other epidermal thickening	0.000	0.997	0.003
M20.2 Hallux rigidus	0.000	0.997	0.003
I63 Cerebral infarction	0.003	0.997	0.000
O47 False labour	0.003	0.997	0.000
N80 Endometriosis	0.000	0.997	0.003
D89.2 Hypergammaglobulinaemia, unspecified	0.003	0.997	0.000
L91.8 Other hypertrophic disorders of skin	0.000	0.997	0.003
L97 Ulcer of lower limb, not elsewhere classified	0.000	0.997	0.003
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified	0.003	0.997	0.000
S80.9 Superficial injury of lower leg, unspecified	0.000	0.997	0.003
O47.9 False labour, unspecified	0.003	0.997	0.000
N80.5 Endometriosis of intestine	0.000	0.997	0.003
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.003	0.997	0.000
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.003	0.997	0.000
N80.2 Endometriosis of Fallopian tube	0.000	0.997	0.003
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)	0.003	0.997	0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.003	0.997	0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.003	0.997	0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.003	0.997	0.000
L85.3 Xerosis cutis	0.000	0.997	0.003
L85.2 Keratosis punctata (palmaris et plantaris)	0.000	0.997	0.003
L85.1 Acquired keratosis [keratoderma] palmaris et plantaris	0.000	0.997	0.003
L85.0 Acquired ichthyosis	0.000	0.997	0.003
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.003	0.997	0.000
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.003	0.997	0.000
N80.3 Endometriosis of pelvic peritoneum	0.000	0.997	0.003
T81.7 Vascular complications following a procedure, not elsewhere classified	0.000	0.997	0.003
L91 Hypertrophic disorders of skin	0.000	0.997	0.003
A08.4 Viral intestinal infection, unspecified	0.000	0.997	0.003
O72.1 Other immediate postpartum haemorrhage	0.003	0.997	0.000
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)	0.003	0.997	0.000
N80.6 Endometriosis in cutaneous scar	0.000	0.997	0.002
N80.4 Endometriosis of rectovaginal septum and vagina	0.000	0.997	0.002
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.000	0.997	0.003
T81 Complications of procedures, not elsewhere classified	0.000	0.997	0.003
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.002	0.998	0.000
N80.9 Endometriosis, unspecified	0.000	0.998	0.002
C78.0 Secondary malignant neoplasm of lung	0.000	0.998	0.002
L80-L99 Other disorders of the skin and subcutaneous tissue	0.000	0.998	0.002
S61.1 Open wound of finger(s) with damage to nail	0.002	0.998	0.000
Z08.9 Follow-up examination after unspecified treatment for malignant neoplasm	0.002	0.998	0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified	0.000	0.998	0.002
N75.1 Abscess of Bartholin's gland	0.000	0.998	0.002
L81.9 Disorder of pigmentation, unspecified	0.000	0.998	0.002
L81 Other disorders of pigmentation	0.000	0.998	0.002
L91.9 Hypertrophic disorder of skin, unspecified	0.000	0.998	0.002
M46.9 Inflammatory spondylopathy, unspecified	0.002	0.998	0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours	0.002	0.998	0.000
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)	0.002	0.998	0.000
N60.1 Diffuse cystic mastopathy	0.000	0.998	0.002
N75.0 Cyst of Bartholin's gland	0.000	0.998	0.002
T81.6 Acute reaction to foreign substance accidentally left during a procedure	0.000	0.998	0.002
H40.1 Primary open-angle glaucoma	0.000	0.998	0.002
N80.8 Other endometriosis	0.000	0.998	0.002
I63.8 Other cerebral infarction	0.002	0.998	0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.002	0.998	0.000
L95 Vasculitis limited to skin, not elsewhere classified	0.000	0.998	0.002
M89.87 Other specified disorders of bone (Ankle and foot)	0.002	0.998	0.000
E11.3 With ophthalmic complications	0.002	0.998	0.000
O47.0 False labour before 37 completed weeks of gestation	0.002	0.998	0.000
T81.3 Disruption of operation wound, not elsewhere classified	0.000	0.998	0.002
L99 Other disorders of skin and subcutaneous tissue in diseases classified elsewhere	0.000	0.998	0.002
L87 Transepidermal elimination disorders	0.000	0.998	0.002
L88 Pyoderma gangrenosum	0.000	0.998	0.002
L86 Keratoderma in diseases classified elsewhere	0.000	0.998	0.002
N80.1 Endometriosis of ovary	0.000	0.998	0.002
L91.0 Keloid scar	0.000	0.998	0.002
S80.0 Contusion of knee	0.000	0.998	0.002
L80 Vitiligo	0.000	0.998	0.002
S62.50 Fracture of thumb (closed)	0.002	0.998	0.000
C50.2 Upper-inner quadrant of breast	0.002	0.998	0.000
G55.2 Nerve root and plexus compressions in spondylosis	0.000	0.998	0.002
B98 Other specified infectious agents as the cause of diseases classified to other chapters	0.000	0.998	0.002
O42 Premature rupture of membranes	0.002	0.998	0.000
C43.7 Malignant melanoma of lower limb, including hip	0.002	0.998	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.002	0.998	0.000
L81.7 Pigmented purpuric dermatosis	0.000	0.998	0.002
L81.6 Other disorders of diminished melanin formation	0.000	0.998	0.002
L81.5 Leukoderma, not elsewhere classified	0.000	0.998	0.002
L81.3 Cafe au lait spots	0.000	0.998	0.002
L81.2 Freckles	0.000	0.998	0.002
L81.1 Chloasma	0.000	0.998	0.002
L81.0 Postinflammatory hyperpigmentation	0.000	0.998	0.002
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.002	0.998	0.000
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)	0.002	0.998	0.000
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)	0.002	0.998	0.000
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)	0.002	0.998	0.000
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)	0.002	0.998	0.000
J38.7 Other diseases of larynx	0.002	0.998	0.000
L93 Lupus erythematosus	0.000	0.998	0.002
S61.9 Open wound of wrist and hand, part unspecified	0.002	0.998	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.002	0.998	0.000
S80 Superficial injury of lower leg	0.000	0.998	0.002
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.002	0.998	0.000
L81.8 Other specified disorders of pigmentation	0.000	0.998	0.002
L95.9 Vasculitis limited to skin, unspecified	0.000	0.998	0.002
N75 Diseases of Bartholin's gland	0.000	0.998	0.002
L85.9 Epidermal thickening, unspecified	0.000	0.998	0.002
L95.8 Other vasculitis limited to skin	0.000	0.998	0.002
L95.1 Erythema elevatum diutinum	0.000	0.998	0.002
L95.0 Livedoid vasculitis	0.000	0.998	0.002
S62.70 Multiple fractures of fingers (closed)	0.002	0.998	0.000
O42.9 Premature rupture of membranes, unspecified	0.002	0.998	0.000
R07.0 Pain in throat	0.002	0.998	0.000
T81.4 Infection following a procedure, not elsewhere classified	0.000	0.998	0.002
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.002	0.998	0.000
L87.9 Transepidermal elimination disorder, unspecified	0.000	0.998	0.001
L87.8 Other transepidermal elimination disorders	0.000	0.998	0.001
L87.2 Elastosis perforans serpiginosa	0.000	0.998	0.001
L87.1 Reactive perforating collagenosis	0.000	0.998	0.001
L87.0 Keratosis follicularis et parafollicularis in cutem penetrans [Kyrle]	0.000	0.998	0.001
L99.8 Other specified disorders of skin and subcutaneous tissue in diseases classified elsewhere	0.000	0.998	0.001
L99.0 Amyloidosis of skin	0.000	0.998	0.001
O32.2 Maternal care for transverse and oblique lie	0.002	0.998	0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)	0.002	0.998	0.000
H54.7 Unspecified visual loss	0.000	0.998	0.002
K50.1 Crohn's disease of large intestine	0.000	0.998	0.002
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.002	0.998	0.000
S62.00 Fracture of navicular [scaphoid] bone of hand (closed)	0.002	0.998	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.002	0.998	0.000
I84.8 Unspecified haemorrhoids with other complications	0.000	0.998	0.002
S62.5 Fracture of thumb	0.002	0.998	0.000
G43.1 Migraine with aura [classical migraine]	0.002	0.998	0.000
L81.4 Other melanin hyperpigmentation	0.000	0.998	0.002
S62.7 Multiple fractures of fingers	0.002	0.998	0.000
L94 Other localised connective tissue disorders	0.000	0.998	0.001
B98.1 Vibrio vulnificus as the cause of diseases classified to other chapters	0.000	0.998	0.001
H02.3 Blepharochalasis	0.000	0.998	0.002
O42.2 Premature rupture of membranes, labour delayed by therapy	0.001	0.998	0.000
O20 Haemorrhage in early pregnancy	0.000	0.998	0.001
K50.0 Crohn's disease of small intestine	0.000	0.998	0.002
Z83.5 Family history of eye and ear disorders	0.002	0.998	0.000
J80 Adult respiratory distress syndrome	0.000	0.998	0.002
L83 Acanthosis nigricans	0.000	0.998	0.001
O85-O92 Complications predominantly related to the puerperium	0.002	0.998	0.000
O86.2 Urinary tract infection following delivery	0.001	0.998	0.000
S62.0 Fracture of navicular [scaphoid] bone of hand	0.002	0.998	0.000
O48 Prolonged pregnancy	0.002	0.998	0.000
S62.61 Fracture of other finger (open)	0.002	0.998	0.000
L93.2 Other local lupus erythematosus	0.000	0.998	0.001
L93.1 Subacute cutaneous lupus erythematosus	0.000	0.998	0.001
O86 Other puerperal infections	0.001	0.998	0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.002	0.998	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.001	0.998	0.000
D89.3 Immune reconstitution syndrome	0.001	0.998	0.000
D89.1 Cryoglobulinaemia	0.001	0.998	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.001	0.998	0.000
I84.3 External thrombosed haemorrhoids	0.000	0.998	0.002
K83.1 Obstruction of bile duct	0.002	0.998	0.000
M06.9 Rheumatoid arthritis, unspecified	0.002	0.998	0.000
S66.8 Injury of other muscles and tendons at wrist and hand level	0.002	0.998	0.000
S62 Fracture at wrist and hand level	0.002	0.998	0.000
S61 Open wound of wrist and hand	0.002	0.998	0.000
J18.0 Bronchopneumonia, unspecified	0.000	0.998	0.002
N75.9 Disease of Bartholin's gland, unspecified	0.000	0.998	0.001
N75.8 Other diseases of Bartholin's gland	0.000	0.998	0.001
S80.7 Multiple superficial injuries of lower leg	0.000	0.998	0.001
S62.10 Fracture of other carpal bone(s) (closed)	0.001	0.998	0.000
S62.20 Fracture of first metacarpal bone (closed)	0.001	0.998	0.000
S62.2 Fracture of first metacarpal bone	0.001	0.998	0.000
S62.1 Fracture of other carpal bone(s)	0.001	0.998	0.000
T81.9 Unspecified complication of procedure	0.000	0.998	0.001
O87 Venous complications in the puerperium	0.001	0.998	0.000
O20.8 Other haemorrhage in early pregnancy	0.000	0.998	0.001
O86.0 Infection of obstetric surgical wound	0.001	0.998	0.000
S80.1 Contusion of other and unspecified parts of lower leg	0.000	0.998	0.001
T21.0 Burn of unspecified degree of trunk	0.001	0.998	0.000
Z80.0 Family history of malignant neoplasm of digestive organs	0.002	0.998	0.000
R02 Gangrene, not elsewhere classified	0.000	0.998	0.002
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.002	0.998	0.000
O32.8 Maternal care for other malpresentation of foetus	0.001	0.998	0.000
S66.0 Injury of long flexor muscle and tendon of thumb at wrist and hand level	0.001	0.998	0.000
T17.9 Foreign body in respiratory tract, part unspecified	0.001	0.998	0.000
O44 Placenta praevia	0.001	0.998	0.000
L89.1 Stage II decubitus ulcer	0.000	0.999	0.001
T81.8 Other complications of procedures, not elsewhere classified	0.000	0.999	0.001
U89.8 Agent resistant to other single specified antibiotic	0.000	0.999	0.001
O90 Complications of the puerperium, not elsewhere classified	0.001	0.999	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.001	0.999	0.000
J18.9 Pneumonia, unspecified	0.000	0.999	0.001
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.001	0.999	0.000
O87.2 Haemorrhoids in the puerperium	0.001	0.999	0.000
O90.1 Disruption of perineal obstetric wound	0.001	0.999	0.000
S66.7 Injury of multiple extensor muscles and tendons at wrist and hand level	0.001	0.999	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.001	0.999	0.000
S62.71 Multiple fractures of fingers (open)	0.001	0.999	0.000
L94.9 Localised connective tissue disorder, unspecified	0.000	0.999	0.001
L94.8 Other specified localised connective tissue disorders	0.000	0.999	0.001
L94.6 Ainhum	0.000	0.999	0.001
L94.5 Poikiloderma vasculare atrophicans	0.000	0.999	0.001
L94.4 Gottron's papules	0.000	0.999	0.001
L94.3 Sclerodactyly	0.000	0.999	0.001
L94.1 Linear scleroderma	0.000	0.999	0.001
N60.4 Mammary duct ectasia	0.000	0.999	0.001
O44.0 Placenta praevia specified as without haemorrhage	0.001	0.999	0.000
L89 Decubitus ulcer	0.000	0.999	0.001
O45 Premature separation of placenta [abruptio placentae]	0.001	0.999	0.000
O32 Maternal care for known or suspected malpresentation of foetus	0.001	0.999	0.000
O40 Polyhydramnios	0.001	0.999	0.000
O92 Other disorders of breast and lactation associated with childbirth	0.001	0.999	0.000
M46.26 Osteomyelitis of vertebra (Lumbar region)	0.001	0.999	0.000
E87.2 Acidosis	0.001	0.999	0.000
J35.0 Chronic tonsillitis	0.000	0.999	0.001
O32.4 Maternal care for high head at term	0.001	0.999	0.000
S62.8 Fracture of other and unspecified parts of wrist and hand	0.001	0.999	0.000
S66.9 Injury of unspecified muscle and tendon at wrist and hand level	0.001	0.999	0.000
L84 Corns and callosities	0.000	0.999	0.001
O91 Infections of breast associated with childbirth	0.001	0.999	0.000
O89 Complications of anaesthesia during the puerperium	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations