TreeWAS – Variant ID: rs4440177

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
R90.8 Other abnormal findings on diagnostic imaging of central nervous system	0.000	0.961	0.038
D70 Agranulocytosis	0.019	0.981	0.000
R90 Abnormal findings on diagnostic imaging of central nervous system	0.000	0.986	0.014
D70-D77 Other diseases of blood and blood-forming organs	0.014	0.986	0.000
O42.0 Premature rupture of membranes, onset of labour within 24 hours	0.000	0.987	0.013
N60.8 Other benign mammary dysplasias	0.000	0.987	0.013
D75 Other diseases of blood and blood-forming organs	0.012	0.988	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.012	0.988	0.000
D75.8 Other specified diseases of blood and blood-forming organs	0.012	0.988	0.000
D76.3 Other histiocytosis syndromes	0.011	0.989	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.011	0.989	0.000
D72 Other disorders of white blood cells	0.010	0.990	0.000
D74 Methaemoglobinaemia	0.010	0.990	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.010	0.990	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.010	0.990	0.000
M84.0 Malunion of fracture	0.000	0.990	0.010
D75.0 Familial erythrocytosis	0.010	0.990	0.000
D72.8 Other specified disorders of white blood cells	0.009	0.991	0.000
M84.03 Malunion of fracture (Forearm)	0.000	0.991	0.009
M84.05 Malunion of fracture (Pelvic region and thigh)	0.000	0.991	0.009
M84.06 Malunion of fracture (Lower leg)	0.000	0.991	0.009
M84.04 Malunion of fracture (Hand)	0.000	0.991	0.009
D76.2 Haemophagocytic syndrome, infection-associated	0.009	0.991	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.009	0.991	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.009	0.991	0.000
M84.02 Malunion of fracture (Upper arm)	0.000	0.991	0.009
R90.0 Intracranial space-occupying lesion	0.000	0.991	0.009
H02.8 Other specified disorders of eyelid	0.008	0.992	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.000	0.992	0.008
M84.01 Malunion of fracture (Shoulder region)	0.000	0.992	0.008
H71 Cholesteatoma of middle ear	0.000	0.992	0.008
D72.9 Disorder of white blood cells, unspecified	0.008	0.992	0.000
D72.0 Genetic anomalies of leukocytes	0.008	0.992	0.000
D74.9 Methaemoglobinaemia, unspecified	0.007	0.993	0.000
D74.8 Other methaemoglobinaemias	0.007	0.993	0.000
D74.0 Congenital methaemoglobinaemia	0.007	0.993	0.000
M84.09 Malunion of fracture (Site unspecified)	0.000	0.993	0.007
M84.08 Malunion of fracture (Other)	0.000	0.993	0.007
M84.00 Malunion of fracture (Multiple sites)	0.000	0.993	0.007
D75.2 Essential thrombocytosis	0.007	0.993	0.000
N28.8 Other specified disorders of kidney and ureter	0.007	0.993	0.000
F43.1 Posttraumatic stress disorder	0.000	0.993	0.007
D75.1 Secondary polycythaemia	0.006	0.993	0.000
F43.2 Adjustment disorders	0.000	0.994	0.006
F43 Reaction to severe stress, and adjustment disorders	0.000	0.994	0.006
F43.9 Reaction to severe stress, unspecified	0.000	0.994	0.006
G50.0 Trigeminal neuralgia	0.000	0.994	0.006
D73 Diseases of spleen	0.005	0.995	0.000
D72.1 Eosinophilia	0.005	0.995	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.995	0.005
D73.4 Cyst of spleen	0.005	0.995	0.000
E89.0 Postprocedural hypothyroidism	0.000	0.995	0.005
N28.0 Ischaemia and infarction of kidney	0.005	0.995	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.995	0.005
A08.4 Viral intestinal infection, unspecified	0.000	0.995	0.005
Y40.0 Penicillins	0.000	0.995	0.005
D73.1 Hypersplenism	0.004	0.995	0.000
F43.8 Other reactions to severe stress	0.000	0.995	0.004
N28 Other disorders of kidney and ureter, not elsewhere classified	0.004	0.996	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.996	0.004
D73.9 Disease of spleen, unspecified	0.004	0.996	0.000
D73.2 Chronic congestive splenomegaly	0.004	0.996	0.000
D80 Immunodeficiency with predominantly antibody defects	0.004	0.996	0.000
D04.6 Skin of upper limb, including shoulder	0.004	0.996	0.000
M06.9 Rheumatoid arthritis, unspecified	0.000	0.996	0.004
A08.1 Acute gastro-enteropathy due to Norwalk agent	0.000	0.996	0.004
D04 Carcinoma in situ of skin	0.004	0.996	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.004	0.996	0.000
D04.1 Skin of eyelid, including canthus	0.004	0.996	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.004	0.996	0.000
F43.0 Acute stress reaction	0.000	0.996	0.004
O42 Premature rupture of membranes	0.000	0.996	0.004
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.004	0.996	0.000
A08 Viral and other specified intestinal infections	0.000	0.996	0.004
D04.4 Skin of scalp and neck	0.004	0.996	0.000
D04.3 Skin of other and unspecified parts of face	0.004	0.996	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.003	0.996	0.000
D12.4 Descending colon	0.004	0.996	0.000
D73.3 Abscess of spleen	0.003	0.996	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.997	0.003
D04.7 Skin of lower limb, including hip	0.003	0.997	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.003	0.997	0.000
D32.0 Cerebral meninges	0.003	0.997	0.000
D73.5 Infarction of spleen	0.003	0.997	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.003	0.997	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.003	0.997	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.003	0.997	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.003	0.997	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.003	0.997	0.000
D80-D89 Certain disorders involving the immune mechanism	0.003	0.997	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.997	0.003
D84.9 Immunodeficiency, unspecified	0.003	0.997	0.000
K43.0 Ventral hernia with obstruction, without gangrene	0.000	0.997	0.003
J03.9 Acute tonsillitis, unspecified	0.003	0.997	0.000
D84 Other immunodeficiencies	0.003	0.997	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.000	0.997	0.003
A08.3 Other viral enteritis	0.000	0.997	0.003
D04.8 Skin of other sites	0.003	0.997	0.000
D04.0 Skin of lip	0.003	0.997	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.997	0.003
D04.9 Skin, unspecified	0.003	0.997	0.000
D04.5 Skin of trunk	0.003	0.997	0.000
G30.9 Alzheimer's disease, unspecified	0.000	0.997	0.003
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.000	0.997	0.003
A08.5 Other specified intestinal infections	0.000	0.997	0.003
A08.2 Adenoviral enteritis	0.000	0.997	0.003
A08.0 Rotaviral enteritis	0.000	0.997	0.003
E89.2 Postprocedural hypoparathyroidism	0.000	0.997	0.003
S86.8 Injury of other muscles and tendons at lower leg level	0.000	0.997	0.003
N39.9 Disorder of urinary system, unspecified	0.003	0.997	0.000
I49.3 Ventricular premature depolarisation	0.003	0.997	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.000	0.997	0.003
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.997	0.003
D73.8 Other diseases of spleen	0.002	0.997	0.001
D86 Sarcoidosis	0.003	0.997	0.000
M25.76 Osteophyte (Lower leg)	0.003	0.997	0.000
N25-N29 Other disorders of kidney and ureter	0.003	0.997	0.000
D04.2 Skin of ear and external auricular canal	0.003	0.997	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.003	0.997	0.000
O42.2 Premature rupture of membranes, labour delayed by therapy	0.000	0.997	0.002
D82 Immunodeficiency associated with other major defects	0.002	0.997	0.000
D81 Combined immunodeficiencies	0.002	0.997	0.000
E89.4 Postprocedural ovarian failure	0.000	0.997	0.003
D83 Common variable immunodeficiency	0.003	0.997	0.000
N26 Unspecified contracted kidney	0.003	0.997	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.003	0.997	0.000
D62 Acute posthaemorrhagic anaemia	0.003	0.997	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.002	0.997	0.000
D84.8 Other specified immunodeficiencies	0.002	0.997	0.000
L72.8 Other follicular cysts of skin and subcutaneous tissue	0.000	0.998	0.002
D84.1 Defects in the complement system	0.002	0.998	0.000
D86.1 Sarcoidosis of lymph nodes	0.002	0.998	0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.000	0.998	0.002
N27 Small kidney of unknown cause	0.002	0.998	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.000	0.998	0.002
E89.8 Other postprocedural endocrine and metabolic disorders	0.000	0.998	0.002
E89.5 Postprocedural testicular hypofunction	0.000	0.998	0.002
E89.1 Postprocedural hypoinsulinaemia	0.000	0.998	0.002
O63.1 Prolonged second stage (of labour)	0.002	0.998	0.000
D86.9 Sarcoidosis, unspecified	0.002	0.998	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.000	0.998	0.002
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.002	0.998	0.000
D32.9 Meninges, unspecified	0.002	0.998	0.000
N27.0 Small kidney, unilateral	0.002	0.998	0.000
Z88.4 Personal history of allergy to anaesthetic agent	0.002	0.998	0.000
S22.30 Fracture of rib (closed)	0.000	0.998	0.002
O42.9 Premature rupture of membranes, unspecified	0.000	0.998	0.002
D32 Benign neoplasm of meninges	0.002	0.998	0.000
D73.0 Hyposplenism	0.002	0.998	0.000
D81.9 Combined immunodeficiency, unspecified	0.002	0.998	0.000
D81.8 Other combined immunodeficiencies	0.002	0.998	0.000
D81.7 Major histocompatibility complex class II deficiency	0.002	0.998	0.000
D81.6 Major histocompatibility complex class I deficiency	0.002	0.998	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.002	0.998	0.000
D81.4 Nezelof's syndrome	0.002	0.998	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.002	0.998	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.002	0.998	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.002	0.998	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.002	0.998	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.002	0.998	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.002	0.998	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.002	0.998	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.002	0.998	0.000
D82.2 Immunodeficiency with short-limbed stature	0.002	0.998	0.000
D82.1 Di George's syndrome	0.002	0.998	0.000
D82.0 Wiskott-Aldrich syndrome	0.002	0.998	0.000
D83.8 Other common variable immunodeficiencies	0.002	0.998	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.002	0.998	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.002	0.998	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.002	0.998	0.000
G51.3 Clonic hemifacial spasm	0.000	0.998	0.002
N29 Other disorders of kidney and ureter in diseases classified elsewhere	0.002	0.998	0.000
D86.8 Sarcoidosis of other and combined sites	0.002	0.998	0.000
D83.9 Common variable immunodeficiency, unspecified	0.002	0.998	0.000
W25.9 Unspecified place	0.000	0.998	0.002
G50 Disorders of trigeminal nerve	0.000	0.998	0.002
K51.4 Pseudopolyposis of colon	0.000	0.998	0.002
S52.30 Fracture of shaft of radius (closed)	0.002	0.998	0.000
N27.9 Small kidney, unspecified	0.002	0.998	0.000
M77.02 Medial epicondylitis (Upper arm)	0.000	0.998	0.002
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)	0.000	0.998	0.002
S01.5 Open wound of lip and oral cavity	0.002	0.998	0.000
N28.9 Disorder of kidney and ureter, unspecified	0.002	0.998	0.000
N27.1 Small kidney, bilateral	0.002	0.998	0.000
N28.1 Cyst of kidney, acquired	0.002	0.998	0.000
D86.3 Sarcoidosis of skin	0.002	0.998	0.000
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.002	0.998	0.000
G50.8 Other disorders of trigeminal nerve	0.000	0.998	0.002
N25 Disorders resulting from impaired renal tubular function	0.002	0.998	0.000
C18.2 Ascending colon	0.002	0.998	0.000
D32.1 Spinal meninges	0.002	0.998	0.000
H59.8 Other postprocedural disorders of eye and adnexa	0.000	0.998	0.002
K42.0 Umbilical hernia with obstruction, without gangrene	0.000	0.998	0.002
I15.1 Hypertension secondary to other renal disorders	0.000	0.998	0.002
N29.1 Other disorders of kidney and ureter in infectious and parasitic diseases classified elsewhere	0.002	0.998	0.000
N29.0 Late syphilis of kidney	0.002	0.998	0.000
D86.0 Sarcoidosis of lung	0.002	0.998	0.000
H10.9 Conjunctivitis, unspecified	0.002	0.998	0.000
N29.8 Other disorders of kidney and ureter in other diseases classified elsewhere	0.002	0.998	0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)	0.002	0.998	0.000
E89.3 Postprocedural hypopituitarism	0.000	0.998	0.002
G50.9 Disorder of trigeminal nerve, unspecified	0.000	0.998	0.002
O32.5 Maternal care for multiple gestation with malpresentation of one foetus or more	0.002	0.998	0.000
S22.50 Flail chest (closed)	0.002	0.998	0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.000	0.998	0.002
S62.00 Fracture of navicular [scaphoid] bone of hand (closed)	0.000	0.998	0.002
E80.4 Gilbert's syndrome	0.002	0.998	0.000
N25.9 Disorder resulting from impaired renal tubular function, unspecified	0.001	0.998	0.000
T90.2 Sequelae of fracture of skull and facial bones	0.002	0.998	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.000	0.998	0.002
N25.0 Renal osteodystrophy	0.001	0.998	0.000
D55-D59 Haemolytic anaemias	0.001	0.998	0.000
N25.1 Nephrogenic diabetes insipidus	0.001	0.998	0.000
D60-D64 Aplastic and other anaemias	0.002	0.998	0.000
R60.0 Localised oedema	0.002	0.998	0.000
N61 Inflammatory disorders of breast	0.000	0.998	0.002
M66.06 Rupture of popliteal cyst-Lower leg	0.002	0.998	0.000
J03 Acute tonsillitis	0.002	0.998	0.000
S86 Injury of muscle and tendon at lower leg level	0.000	0.998	0.002
K12.1 Other forms of stomatitis	0.000	0.998	0.002
H66.3 Other chronic suppurative otitis media	0.000	0.998	0.001
N64.5 Other signs and symptoms in breast	0.000	0.998	0.002
H10.5 Blepharoconjunctivitis	0.001	0.999	0.000
I44.1 Atrioventricular block, second degree	0.001	0.999	0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.000	0.999	0.001
W79.2 School, other institution and public administrative area	0.001	0.999	0.000
S72.90 Fracture of femur, part unspecified (closed)	0.000	0.999	0.001
J13 Pneumonia due to Streptococcus pneumoniae	0.001	0.999	0.000
D57 Sickle-cell disorders	0.001	0.999	0.000
D55 Anaemia due to enzyme disorders	0.001	0.999	0.000
F00.9 Dementia in Alzheimer's disease, unspecified	0.000	0.999	0.001
G50.1 Atypical facial pain	0.000	0.999	0.001
H10.3 Acute conjunctivitis, unspecified	0.001	0.999	0.000
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.000	0.999	0.001
G47.1 Disorders of excessive somnolence [hypersomnias]	0.000	0.999	0.001
J03.8 Acute tonsillitis due to other specified organisms	0.001	0.999	0.000
J03.0 Streptococcal tonsillitis	0.001	0.999	0.000
S81.9 Open wound of lower leg, part unspecified	0.001	0.999	0.000
S86.0 Injury of Achilles tendon	0.000	0.999	0.001
S86.7 Injury of multiple muscles and tendons at lower leg level	0.000	0.999	0.001
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.000	0.999	0.001
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.001	0.999	0.000
G30 Alzheimer's disease	0.000	0.999	0.001
M41.99 Scoliosis, unspecified (Site unspecified)	0.001	0.999	0.000
H10 Conjunctivitis	0.001	0.999	0.000
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.001	0.999	0.000
E65 Localised adiposity	0.000	0.999	0.001
E05.8 Other thyrotoxicosis	0.001	0.999	0.000
O20.9 Haemorrhage in early pregnancy, unspecified	0.000	0.999	0.001
O87.2 Haemorrhoids in the puerperium	0.001	0.999	0.000
S64.0 Injury of ulnar nerve at wrist and hand level	0.000	0.999	0.001
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.001	0.999	0.000
Z08.9 Follow-up examination after unspecified treatment for malignant neoplasm	0.001	0.999	0.000
D56 Thalassaemia	0.001	0.999	0.000
K43 Ventral hernia	0.000	0.999	0.001
D55.9 Anaemia due to enzyme disorder, unspecified	0.001	0.999	0.000
D55.8 Other anaemias due to enzyme disorders	0.001	0.999	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.001	0.999	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.001	0.999	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.001	0.999	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.001	0.999	0.000
D57.8 Other sickle-cell disorders	0.001	0.999	0.000
D57.3 Sickle-cell trait	0.001	0.999	0.000
D57.2 Double heterozygous sickling disorders	0.001	0.999	0.000
D57.1 Sickle-cell anaemia without crisis	0.001	0.999	0.000
D57.0 Sickle-cell anaemia with crisis	0.001	0.999	0.000
I15.9 Seconday hypertension, unspecified	0.000	0.999	0.001
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.001	0.999	0.000
M25.78 Osteophyte (Other)	0.001	0.999	0.000
Y46.4 Iminostilbenes	0.001	0.999	0.000
M24.07 Loose body in joint (Ankle and foot)	0.000	0.999	0.001
S86.00 Unspecified injury of Achilles tendon	0.000	0.999	0.001
N25.8 Other disorders resulting from impaired renal tubular function	0.001	0.999	0.000
W50.9 Unspecified place	0.001	0.999	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.001	0.999	0.000
D60.8 Other acquired pure red cell aplasias	0.001	0.999	0.000
D60.1 Transient acquired pure red cell aplasia	0.001	0.999	0.000
D60.0 Chronic acquired pure red cell aplasia	0.001	0.999	0.000
Y40.3 Macrolides	0.000	0.999	0.001
D58 Other hereditary haemolytic anaemias	0.001	0.999	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.001	0.999	0.000
A02.0 Salmonella gastro-enteritis	0.000	0.999	0.001
G30.0 Alzheimer's disease with early onset	0.000	0.999	0.001
H10.8 Other conjunctivitis	0.001	0.999	0.000
H10.2 Other acute conjunctivitis	0.001	0.999	0.000
H10.1 Acute atopic conjunctivitis	0.001	0.999	0.000
H10.0 Mucopurulent conjunctivitis	0.001	0.999	0.000
H47.2 Optic atrophy	0.000	0.999	0.001
K35.0 Acute appendicitis with generalised peritonitis	0.001	0.999	0.000
D59 Acquired haemolytic anaemia	0.001	0.999	0.000
M84 Disorders of continuity of bone	0.000	0.999	0.001
S32.10 Fracture of sacrum (closed)	0.001	0.999	0.000
D56.9 Thalassaemia, unspecified	0.001	0.999	0.000
D56.8 Other thalassaemias	0.001	0.999	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.001	0.999	0.000
D56.2 Delta-beta thalassaemia	0.001	0.999	0.000
D56.0 Alpha thalassaemia	0.001	0.999	0.000
F50.9 Eating disorder, unspecified	0.001	0.999	0.000
H54.0 Blindness, both eyes	0.000	0.999	0.001
K43.7 Other and unspecified ventral hernia with gangrene	0.000	0.999	0.001
K43.6 Other and unspecified ventral hernia with obstruction, without gangrene	0.000	0.999	0.001
K43.5 Parastomal hernia without obstruction or gangrene	0.000	0.999	0.001
K43.4 Parastomal hernia with gangrene	0.000	0.999	0.001
K43.3 Parastomal hernia with obstruction, without gangrene	0.000	0.999	0.001
K43.2 Incisional hernia without obstruction or gangrene	0.000	0.999	0.001
K43.1 Ventral hernia with gangrene	0.000	0.999	0.001
M77.0 Medial epicondylitis	0.000	0.999	0.001
M80.0 Postmenopausal osteoporosis with pathological fracture	0.001	0.999	0.000
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)	0.000	0.999	0.001
M65.95 Synovitis and tenosynovitis, unspecified (Pelvic region and thigh)	0.000	0.999	0.001
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.001	0.999	0.000
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.001	0.999	0.000
S27.10 Traumatic haemothorax (without open wound into thoracic cavity)	0.001	0.999	0.000
D60.9 Acquired pure red cell aplasia, unspecified	0.001	0.999	0.000
D89.3 Immune reconstitution syndrome	0.001	0.999	0.000
F15.1 Harmful use	0.001	0.999	0.000
G30.1 Alzheimer's disease with late onset	0.000	0.999	0.001
H10.4 Chronic conjunctivitis	0.001	0.999	0.000
N48.6 Balanitis xerotica obliterans	0.001	0.999	0.000
M65.86 Other synovitis and tenosynovitis (Lower leg)	0.000	0.999	0.001
D56.1 Beta thalassaemia	0.001	0.999	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.001	0.999	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.001	0.999	0.000
D58.2 Other haemoglobinopathies	0.001	0.999	0.000
D58.1 Hereditary elliptocytosis	0.001	0.999	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.001	0.999	0.000
H31.0 Chorioretinal scars	0.001	0.999	0.000
H66.1 Chronic tubotympanic suppurative otitis media	0.000	0.999	0.001
I79.1 Aortitis in diseases classified elsewhere	0.001	0.999	0.000
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.001	0.999	0.000
S89.9 Unspecified injury of lower leg	0.000	0.999	0.001
M80.09 Postmenopausal osteoporosis with pathological fracture (Site unspecified)	0.001	0.999	0.000
M80.08 Postmenopausal osteoporosis with pathological fracture (Other)	0.001	0.999	0.000
M80.07 Postmenopausal osteoporosis with pathological fracture (Ankle and foot)	0.001	0.999	0.000
M80.06 Postmenopausal osteoporosis with pathological fracture (Lower leg)	0.001	0.999	0.000
M80.05 Postmenopausal osteoporosis with pathological fracture (Pelvic region and thigh)	0.001	0.999	0.000
M80.04 Postmenopausal osteoporosis with pathological fracture (Hand)	0.001	0.999	0.000
M80.03 Postmenopausal osteoporosis with pathological fracture (Forearm)	0.001	0.999	0.000
M80.02 Postmenopausal osteoporosis with pathological fracture (Upper arm)	0.001	0.999	0.000
M80.01 Postmenopausal osteoporosis with pathological fracture (Shoulder region)	0.001	0.999	0.000
D59.8 Other acquired haemolytic anaemias	0.001	0.999	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.001	0.999	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.001	0.999	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.001	0.999	0.000
D59.3 Haemolytic-uraemic syndrome	0.001	0.999	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.001	0.999	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.001	0.999	0.000
M84.9 Disorder of continuity of bone, unspecified	0.000	0.999	0.001
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.000	0.999	0.001
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.999	0.001
M77.09 Medial epicondylitis (Site unspecified)	0.000	0.999	0.001
M77.08 Medial epicondylitis-Other	0.000	0.999	0.001
M77.07 Medial epicondylitis-Ankle/Foot	0.000	0.999	0.001
M77.06 Medial epicondylitis (Lower leg)	0.000	0.999	0.001
M77.05 Medial epicondylitis (Pelvic region and thigh)	0.000	0.999	0.001
M77.04 Medial epicondylitis-Hand	0.000	0.999	0.001
M77.03 Medial epicondylitis-Forearm	0.000	0.999	0.001
M77.01 Medial epicondylitis-Shldr region	0.000	0.999	0.001
M77.00 Medial epicondylitis (Multiple sites)	0.000	0.999	0.001
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.001	0.999	0.000
S22.3 Fracture of rib	0.000	0.999	0.001
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.001	0.999	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.001	0.999	0.000
G30.8 Other Alzheimer's disease	0.000	0.999	0.001
M62.80 Other specified disorders of muscle (Multiple sites)	0.000	0.999	0.001
D09.0 Bladder	0.000	0.999	0.001
H47.1 Papilloedema, unspecified	0.000	0.999	0.001
K73.2 Chronic active hepatitis, not elsewhere classified	0.001	0.999	0.000
M84.3 Stress fracture, not elsewhere classified	0.000	0.999	0.001
M84.99 Disorder of continuity of bone, unspecified (Site unspecified)	0.000	0.999	0.001
M84.98 Disorder of continuity of bone, unspecified (Other)	0.000	0.999	0.001
M84.97 Disorder of continuity of bone, unspecified (Ankle and foot)	0.000	0.999	0.001
M84.96 Disorder of continuity of bone, unspecified (Lower leg)	0.000	0.999	0.001
M84.95 Disorder of continuity of bone, unspecified (Pelvic region and thigh)	0.000	0.999	0.001
M84.94 Disorder of continuity of bone, unspecified (Hand)	0.000	0.999	0.001
M84.93 Disorder of continuity of bone, unspecified (Forearm)	0.000	0.999	0.001
M84.92 Disorder of continuity of bone, unspecified (Upper arm)	0.000	0.999	0.001
M84.91 Disorder of continuity of bone, unspecified (Shoulder region)	0.000	0.999	0.001
M84.90 Disorder of continuity of bone, unspecified (Multiple sites)	0.000	0.999	0.001
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.001	0.999	0.000
S22.31 Fracture of rib (open)	0.000	0.999	0.001
D56.3 Thalassaemia trait	0.001	0.999	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.001	0.999	0.000
D89.1 Cryoglobulinaemia	0.001	0.999	0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.001	0.999	0.000
D67 Hereditary factor IX deficiency	0.001	0.999	0.000
M76.67 Achilles tendinitis (Ankle and foot)	0.000	0.999	0.001
M84.13 Nonunion of fracture [pseudarthrosis] (Forearm)	0.000	0.999	0.001
A40.3 Septicaemia due to Streptococcus pneumoniae	0.001	0.999	0.000
D58.0 Hereditary spherocytosis	0.000	0.999	0.001
M84.8 Other disorders of continuity of bone	0.000	0.999	0.001
M84.2 Delayed union of fracture	0.000	0.999	0.001
O32.2 Maternal care for transverse and oblique lie	0.001	0.999	0.000
M54.47 Lumbago with sciatica (Lumbosacral region)	0.001	0.999	0.000
M62.82 Other specified disorders of muscle (Upper arm)	0.000	0.999	0.001
M65.90 Synovitis and tenosynovitis, unspecified (Multiple sites)	0.000	0.999	0.001
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.000	0.999	0.001
M84.38 Stress fracture, not elsewhere classified (Other)	0.000	0.999	0.001
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.000	0.999	0.001
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.000	0.999	0.001
M84.34 Stress fracture, not elsewhere classified (Hand)	0.000	0.999	0.001
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.000	0.999	0.001
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.000	0.999	0.001
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.000	0.999	0.001
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.000	0.999	0.001
M65.9 Synovitis and tenosynovitis, unspecified	0.000	0.999	0.001
S51.8 Open wound of other parts of forearm	0.001	0.999	0.000
Y40 Systemic antibiotics	0.000	0.999	0.001
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)	0.000	0.999	0.001
M84.29 Delayed union of fracture (Site unspecified)	0.000	0.999	0.001
M84.28 Delayed union of fracture (Other)	0.000	0.999	0.001
M84.27 Delayed union of fracture (Ankle and foot)	0.000	0.999	0.001
M84.25 Delayed union of fracture (Pelvic region and thigh)	0.000	0.999	0.001
M84.24 Delayed union of fracture (Hand)	0.000	0.999	0.001
M84.23 Delayed union of fracture (Forearm)	0.000	0.999	0.001
M84.22 Delayed union of fracture (Upper arm)	0.000	0.999	0.001
M84.20 Delayed union of fracture (Multiple sites)	0.000	0.999	0.001
M84.89 Other disorders of continuity of bone (Site unspecified)	0.000	0.999	0.001
M84.88 Other disorders of continuity of bone (Other)	0.000	0.999	0.001
M84.86 Other disorders of continuity of bone (Lower leg)	0.000	0.999	0.001
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.000	0.999	0.001
M84.84 Other disorders of continuity of bone (Hand)	0.000	0.999	0.001
M84.83 Other disorders of continuity of bone (Forearm)	0.000	0.999	0.001
M84.82 Other disorders of continuity of bone (Upper arm)	0.000	0.999	0.001
M84.81 Other disorders of continuity of bone (Shoulder region)	0.000	0.999	0.001
M84.80 Other disorders of continuity of bone (Multiple sites)	0.000	0.999	0.001
H66.4 Suppurative otitis media, unspecified	0.000	0.999	0.001
H72.8 Other perforations of tympanic membrane	0.000	0.999	0.001
J15.5 Pneumonia due to Escherichia coli	0.001	0.999	0.000
S79.9 Unspecified injury of hip and thigh	0.000	0.999	0.001
I15 Secondary hypertension	0.000	0.999	0.001
M62.81 Other specified disorders of muscle (Shoulder region)	0.000	0.999	0.001
M65.98 Synovitis and tenosynovitis, unspecified (Other)	0.000	0.999	0.001
M84.21 Delayed union of fracture (Shoulder region)	0.001	0.999	0.000
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.001	0.999	0.000
C41.9 Bone and articular cartilage, unspecified	0.001	0.999	0.000
E22.0 Acromegaly and pituitary gigantism	0.000	0.999	0.001
F19.2 Dependence syndrome	0.001	0.999	0.000
I45.1 Other and unspecified right bundle-branch block	0.001	0.999	0.000
M66.0 Rupture of popliteal cyst	0.001	0.999	0.000
M85.8 Other specified disorders of bone density and structure	0.001	0.999	0.000
O87.8 Other venous complications in the puerperium	0.001	0.999	0.000
Y40.4 Tetracyclines	0.000	0.999	0.001
Y40.2 Chloramphenicol group	0.000	0.999	0.001
W79 Inhalation and ingestion of food causing obstruction of respiratory tract	0.001	0.999	0.000
M66.09 Rupture of popliteal cyst-Site unspec	0.001	0.999	0.000
M66.08 Rupture of popliteal cyst-Other	0.001	0.999	0.000
M66.07 Rupture of popliteal cyst-Ankle/foot	0.001	0.999	0.000
M66.05 Rupture of popliteal cyst-Pelvic/thigh	0.001	0.999	0.000
M66.04 Rupture of popliteal cyst-Hand	0.001	0.999	0.000
M66.03 Rupture of popliteal cyst-Forearm	0.001	0.999	0.000
M66.02 Rupture of popliteal cyst-Upper arm	0.001	0.999	0.000
M66.01 Rupture of popliteal cyst-Shldr region	0.001	0.999	0.000
M66.00 Rupture of popliteal cyst-Mult sites	0.001	0.999	0.000
M84.26 Delayed union of fracture (Lower leg)	0.001	0.999	0.000
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.000	0.999	0.001
C43.3 Malignant melanoma of other and unspecified parts of face	0.000	0.999	0.001
F15.0 Acute intoxication	0.001	0.999	0.000
I15.8 Other secondary hypertension	0.000	0.999	0.001
N94.8 Other specified conditions associated with female genital organs and menstrual cycle	0.001	0.999	0.000
W79.9 Unspecified place	0.001	0.999	0.000
W79.0 Home	0.001	0.999	0.000
W79.8 Other specified place	0.001	0.999	0.000
W79.7 Farm	0.001	0.999	0.000
W79.6 Industrial and construction area	0.001	0.999	0.000
W79.5 Trade and service area	0.001	0.999	0.000
W79.4 Street and highway	0.001	0.999	0.000
W79.3 Sports and athletics area	0.001	0.999	0.000
W79.1 Residential institution	0.001	0.999	0.000
Y85.0 Sequelae of motor-vehicle accident	0.000	0.999	0.001
M24.24 Disorder of ligament (Hand)	0.000	0.999	0.001
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.001	0.999	0.001
M85.84 Other specified disorders of bone density and structure (Hand)	0.001	0.999	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.001	0.999	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.001	0.999	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.001	0.999	0.000
W79.09 Inhalation and ingestion of food causing obstruction of respiratory tract, Home , During unspecified activity	0.001	0.999	0.000
W79.04 Inhalation and ingestion of food causing obstruction of respiratory tract; Home; While resting, sleeping, eating or engaging in other vital activities	0.001	0.999	0.000
W79.99 Inhalation and ingestion of food causing obstruction of respiratory tract; Unspecified place ;During unspecified activity	0.001	0.999	0.000
W79.94 Inhalation and ingestion of food causing obstruction of respiratory tract; Unspecified place ;While resting, sleeping, eating or engaging in other vital activities	0.001	0.999	0.000
C49.2 Connective and soft tissue of lower limb, including hip	0.001	0.999	0.000
G51.9 Disorder of facial nerve, unspecified	0.000	0.999	0.001
H17.8 Other corneal scars and opacities	0.000	0.999	0.001
K43.9 Ventral hernia without obstruction or gangrene	0.000	0.999	0.001
O87.0 Superficial thrombophlebitis in the puerperium	0.001	0.999	0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.001	0.999	0.000
M24.27 Disorder of ligament (Ankle and foot)	0.000	0.999	0.001
S37.00 Injury of kidney (without open wound into cavity)	0.001	0.999	0.000
I15.0 Renovascular hypertension	0.000	0.999	0.001
L28.0 Lichen simplex chronicus	0.001	0.999	0.000
Q39.6 Diverticulum of oesophagus	0.001	0.999	0.000
S81.8 Open wound of other parts of lower leg	0.001	0.999	0.000
S93.0 Dislocation of ankle joint	0.000	0.999	0.001
Y46.6 Other and unspecified antiepileptics	0.001	0.999	0.000
M24.26 Disorder of ligament (Lower leg)	0.000	0.999	0.001
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.001	0.999	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.001	0.999	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.001	0.999	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.001	0.999	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations