TreeWAS – Variant ID: rs4650135

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
N18.5 Chronic kidney disease, stage 5	0.000	0.843	0.157
N18 Chronic renal failure	0.000	0.854	0.146
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.000	0.854	0.146
N18.9 Chronic renal failure, unspecified	0.000	0.855	0.145
N18.0 End-stage renal disease	0.000	0.857	0.143
T85 Complications of other internal prosthetic devices, implants and grafts	0.000	0.865	0.135
T85.4 Mechanical complication of breast prosthesis and implant	0.000	0.869	0.131
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts	0.000	0.871	0.129
N18.8 Other chronic renal failure	0.000	0.878	0.122
C67.9 Bladder, unspecified	0.000	0.885	0.115
C67 Malignant neoplasm of bladder	0.000	0.890	0.110
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt	0.000	0.892	0.108
C67.3 Anterior wall of bladder	0.000	0.900	0.100
T85.9 Unspecified complication of internal prosthetic device, implant and graft	0.000	0.900	0.100
T85.2 Mechanical complication of intraocular lens	0.000	0.903	0.097
C67.2 Lateral wall of bladder	0.000	0.907	0.093
N18.1 Chronic kidney disease, stage 1	0.000	0.908	0.092
C67.6 Ureteric orifice	0.000	0.908	0.092
T85.1 Mechanical complication of implanted electronic stimulator of nervous system	0.000	0.909	0.090
C67.8 Overlapping lesion of bladder	0.000	0.911	0.089
C67.1 Dome of bladder	0.000	0.914	0.086
C67.5 Bladder neck	0.000	0.916	0.084
C67.4 Posterior wall of bladder	0.000	0.921	0.079
C67.7 Urachus	0.000	0.921	0.079
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.000	0.923	0.077
C67.0 Trigone of bladder	0.000	0.924	0.076
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.000	0.925	0.075
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.000	0.926	0.074
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts	0.000	0.926	0.073
N18.4 Chronic kidney disease, stage 4	0.000	0.928	0.072
T82.0 Mechanical complication of heart valve prosthesis	0.000	0.931	0.068
N18.2 Chronic kidney disease, stage 2	0.000	0.932	0.068
T82.4 Mechanical complication of vascular dialysis catheter	0.000	0.933	0.067
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.000	0.934	0.066
T86 Failure and rejection of transplanted organs and tissues	0.000	0.935	0.065
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.000	0.939	0.061
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified	0.000	0.940	0.060
T87 Complications peculiar to reattachment and amputation	0.000	0.942	0.058
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.000	0.942	0.058
T82.3 Mechanical complication of other vascular grafts	0.000	0.942	0.058
T86.8 Failure and rejection of other transplanted organs and tissues	0.000	0.943	0.057
T88 Other complications of surgical and medical care, not elsewhere classified	0.000	0.945	0.055
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.000	0.946	0.054
T86.1 Kidney transplant failure and rejection	0.000	0.947	0.052
T80 Complications following infusion, transfusion and therapeutic injection	0.000	0.949	0.051
T82.1 Mechanical complication of cardiac electronic device	0.000	0.951	0.049
T87.6 Other and unspecified complications of amputation stump	0.000	0.951	0.049
T88.4 Failed or difficult intubation	0.000	0.952	0.048
T86.9 Failure and rejection of unspecified transplanted organ and tissue	0.000	0.953	0.047
T86.3 Heart-lung transplant failure and rejection	0.000	0.953	0.047
T86.2 Heart transplant failure and rejection	0.000	0.953	0.047
T86.0 Bone-marrow transplant rejection	0.000	0.953	0.047
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts	0.000	0.955	0.045
T88.5 Other complications of anaesthesia	0.000	0.955	0.045
T86.4 Liver transplant failure and rejection	0.000	0.958	0.042
T87.5 Necrosis of amputation stump	0.000	0.958	0.042
T87.2 Complications of other reattached body part	0.000	0.958	0.042
T87.1 Complications of reattached (part of) lower extremity	0.000	0.958	0.042
T87.0 Complications of reattached (part of) upper extremity	0.000	0.958	0.042
T87.4 Infection of amputation stump	0.000	0.959	0.041
T80.1 Vascular complications following infusion, transfusion and therapeutic injection	0.000	0.959	0.041
T88.7 Unspecified adverse effect of drug or medicament	0.000	0.960	0.040
T88.3 Malignant hyperthermia due to anaesthesis	0.000	0.960	0.039
T88.2 Shock due to anaesthesia	0.000	0.960	0.039
T88.1 Other complications following immunisation, not elsewhere classified	0.000	0.960	0.039
T88.0 Infection following immunisation	0.000	0.960	0.039
T87.3 Neuroma of amputation stump	0.000	0.963	0.037
T80.6 Other serum reactions	0.000	0.963	0.037
T80.5 Anaphylactic shock due to serum	0.000	0.963	0.037
T80.4 Rh incompatibility reaction	0.000	0.963	0.037
T80.3 ABO incompatibility reaction	0.000	0.963	0.037
T80.0 Air embolism following infusion, transfusion and therapeutic injection	0.000	0.963	0.037
T80.8 Other complications following infusion, transfusion and therapeutic injection	0.000	0.963	0.037
T88.9 Complication of surgical and medical care, unspecified	0.000	0.963	0.036
T80.2 Infections following infusion, transfusion and therapeutic injection	0.000	0.967	0.033
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.000	0.967	0.033
T80.9 Unspecified complication following infusion, transfusion and therapeutic injection	0.000	0.967	0.032
T88.8 Other specified complications of surgical and medical care, not elsewhere classified	0.000	0.968	0.032
N18.3 Chronic kidney disease, stage 3	0.000	0.971	0.029
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered	0.000	0.973	0.026
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft	0.000	0.974	0.026
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.001	0.974	0.025
T83.3 Mechanical complication of intra-uterine contraceptive device	0.000	0.974	0.026
N48.6 Balanitis xerotica obliterans	0.025	0.975	0.000
T83.2 Mechanical complication of graft of urinary organ	0.000	0.976	0.024
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system	0.000	0.976	0.024
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract	0.000	0.977	0.023
N17-N19 Renal failure	0.000	0.978	0.022
T83.0 Mechanical complication of urinary (indwelling) catheter	0.000	0.980	0.020
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract	0.000	0.980	0.020
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts	0.000	0.981	0.019
R41.0 Disorientation, unspecified	0.000	0.982	0.018
T83.1 Mechanical complication of other urinary devices and implants	0.000	0.983	0.017
C71 Malignant neoplasm of brain	0.016	0.984	0.000
C71.1 Frontal lobe	0.016	0.984	0.000
Z99.2 Dependence on renal dialysis	0.000	0.984	0.016
C71.9 Brain, unspecified	0.015	0.985	0.000
Z80.4 Family history of malignant neoplasm of genital organs	0.000	0.986	0.014
K85.9 Acute pancreatitis, unspecified	0.000	0.987	0.013
C71.2 Temporal lobe	0.013	0.987	0.000
C71.4 Occipital lobe	0.013	0.987	0.000
C71.8 Overlapping lesion of brain	0.013	0.987	0.000
C71.3 Parietal lobe	0.013	0.987	0.000
C71.0 Cerebrum, except lobes and ventricles	0.012	0.988	0.000
C64-C68 Malignant neoplasms of urinary tract	0.000	0.988	0.012
C71.7 Brain stem	0.011	0.988	0.000
C71.6 Cerebellum	0.011	0.988	0.000
C71.5 Cerebral ventricle	0.011	0.988	0.000
N19 Unspecified renal failure	0.000	0.989	0.011
M34.9 Systemic sclerosis, unspecified	0.011	0.989	0.000
K85 Acute pancreatitis	0.000	0.991	0.009
K85.1 Biliary acute pancreatitis	0.000	0.991	0.009
N17 Acute renal failure	0.000	0.991	0.009
M34 Systemic sclerosis	0.009	0.991	0.000
M34.8 Other forms of systemic sclerosis	0.008	0.992	0.000
K85.2 Alcohol-induced acute pancreatitis	0.000	0.992	0.008
C68 Malignant neoplasm of other and unspecified urinary organs	0.000	0.992	0.008
M34.1 CR(E)ST syndrome	0.008	0.992	0.000
C65 Malignant neoplasm of renal pelvis	0.000	0.992	0.007
K50.9 Crohn's disease, unspecified	0.008	0.992	0.000
K85.8 Other acute pancreatitis	0.000	0.993	0.007
K85.3 Drug-induced acute pancreatitis	0.000	0.993	0.007
N17.8 Other acute renal failure	0.000	0.993	0.006
N17.2 Acute renal failure with medullary necrosis	0.000	0.993	0.006
N17.1 Acute renal failure with acute cortical necrosis	0.000	0.993	0.006
R41 Other symptoms and signs involving cognitive functions and awareness	0.000	0.993	0.007
M34.2 Systemic sclerosis induced by drugs and chemicals	0.006	0.994	0.000
M34.0 Progressive systemic sclerosis	0.006	0.994	0.000
C66 Malignant neoplasm of ureter	0.000	0.994	0.006
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.006	0.994	0.000
R41.3 Other amnesia	0.000	0.994	0.006
C68.9 Urinary organ, unspecified	0.000	0.994	0.006
C68.8 Overlapping lesion of urinary organs	0.000	0.994	0.006
C68.1 Paraurethral glands	0.000	0.994	0.006
N17.0 Acute renal failure with tubular necrosis	0.000	0.994	0.006
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.000	0.994	0.006
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.006	0.994	0.000
K85.0 Idiopathic acute pancreatitis	0.000	0.995	0.005
C68.0 Urethra	0.000	0.995	0.005
R41.1 Anterograde amnesia	0.000	0.995	0.005
T84.2 Mechanical complication of internal fixation device of other bones	0.000	0.995	0.005
K50.1 Crohn's disease of large intestine	0.005	0.995	0.000
D80 Immunodeficiency with predominantly antibody defects	0.005	0.995	0.000
K50 Crohn's disease [regional enteritis]	0.005	0.995	0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.000	0.995	0.005
T84.3 Mechanical complication of other bone devices, implants and grafts	0.000	0.995	0.005
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.005	0.995	0.000
C70 Malignant neoplasm of meninges	0.005	0.995	0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.005	0.995	0.000
C69 Malignant neoplasm of eye and adnexa	0.005	0.995	0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.000	0.995	0.005
C64 Malignant neoplasm of kidney, except renal pelvis	0.000	0.995	0.005
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.004	0.995	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.004	0.996	0.000
O82.0 Delivery by elective Caesarean section	0.000	0.996	0.004
K50.8 Other Crohn's disease	0.004	0.996	0.000
T92.2 Sequelae of fracture at wrist and hand level	0.004	0.996	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.004	0.996	0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified	0.000	0.996	0.004
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness	0.000	0.996	0.004
T81 Complications of procedures, not elsewhere classified	0.000	0.996	0.004
K35.8 Acute appendicitis, other and unspecified	0.004	0.996	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.004	0.996	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.004	0.996	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.004	0.996	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.004	0.996	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.004	0.996	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.004	0.996	0.000
C69.9 Eye, unspecified	0.004	0.996	0.000
C69.6 Orbit	0.004	0.996	0.000
K58.9 Irritable bowel syndrome without diarrhoea	0.000	0.996	0.004
C70.9 Meninges, unspecified	0.004	0.996	0.000
C70.1 Spinal meninges	0.004	0.996	0.000
C70.0 Cerebral meninges	0.004	0.996	0.000
C72.9 Central nervous system, unspecified	0.004	0.996	0.000
C72.8 Overlapping lesion of brain and other parts of central nervous system	0.004	0.996	0.000
C72.5 Other and unspecified cranial nerves	0.004	0.996	0.000
C72.4 Acoustic nerve	0.004	0.996	0.000
C72.3 Optic nerve	0.004	0.996	0.000
C72.2 Olfactory nerve	0.004	0.996	0.000
C72.1 Cauda equina	0.004	0.996	0.000
C72.0 Spinal cord	0.004	0.996	0.000
N48 Other disorders of penis	0.004	0.996	0.000
C69.0 Conjunctiva	0.004	0.996	0.000
N43.3 Hydrocele, unspecified	0.000	0.996	0.004
C69.8 Overlapping lesion of eye and adnexa	0.003	0.996	0.000
C69.5 Lachrymal gland and duct	0.003	0.996	0.000
C69.4 Ciliary body	0.003	0.996	0.000
C69.2 Retina	0.003	0.996	0.000
C69.1 Cornea	0.003	0.996	0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure	0.000	0.997	0.003
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified	0.000	0.997	0.003
R90.8 Other abnormal findings on diagnostic imaging of central nervous system	0.003	0.997	0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.000	0.997	0.003
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.000	0.997	0.003
T50.9 Other and unspecified drugs, medicaments and biological substances	0.000	0.997	0.003
N48.5 Ulcer of penis	0.003	0.997	0.000
Z80.8 Family history of malignant neoplasm of other organs or systems	0.000	0.997	0.003
Z99.9 Dependence on unspecified enabling machine and device	0.000	0.997	0.003
Z99.4 Dependence on artificial heart	0.000	0.997	0.003
Z99.0 Dependence on aspirator	0.000	0.997	0.003
T81.9 Unspecified complication of procedure	0.000	0.997	0.003
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.000	0.997	0.003
Z99.3 Dependence on wheelchair	0.000	0.997	0.003
T81.6 Acute reaction to foreign substance accidentally left during a procedure	0.000	0.997	0.003
N48.2 Other inflammatory disorders of penis	0.003	0.997	0.000
H72.9 Perforation of tympanic membrane, unspecified	0.003	0.997	0.000
Z99.1 Dependence on respirator	0.000	0.997	0.003
G31.8 Other specified degenerative diseases of nervous system	0.000	0.997	0.003
N48.1 Balanoposthitis	0.003	0.997	0.000
C69.3 Choroid	0.003	0.997	0.000
N48.4 Impotence of organic origin	0.003	0.997	0.000
C78.0 Secondary malignant neoplasm of lung	0.000	0.997	0.003
N48.3 Priapism	0.003	0.997	0.000
Z80 Family history of malignant neoplasm	0.000	0.997	0.003
Z80.5 Family history of malignant neoplasm of urinary tract	0.000	0.997	0.003
D36.1 Peripheral nerves and autonomic nervous system	0.000	0.997	0.003
R41.2 Retrograde amnesia	0.001	0.997	0.002
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.000	0.997	0.003
J35.0 Chronic tonsillitis	0.000	0.997	0.003
F17.2 Dependence syndrome	0.003	0.997	0.000
R50.9 Fever, unspecified	0.000	0.997	0.003
T81.8 Other complications of procedures, not elsewhere classified	0.000	0.997	0.003
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.001	0.997	0.002
D80-D89 Certain disorders involving the immune mechanism	0.003	0.997	0.000
M95.0 Acquired deformity of nose	0.003	0.997	0.000
R22.3 Localised swelling, mass and lump, upper limb	0.000	0.997	0.003
K41.9 Unilateral or unspecified femoral hernia, without obstruction or gangrene	0.002	0.998	0.000
K51.2 Ulcerative (chronic) proctitis	0.002	0.998	0.000
Z80.6 Family history of leukaemia	0.000	0.998	0.002
B37.3 Candidiasis of vulva and vagina	0.002	0.998	0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified	0.000	0.998	0.002
M25.75 Osteophyte (Pelvic region and thigh)	0.002	0.998	0.000
Z80.2 Family history of malignant neoplasm of other respiratory and intrathoracic organs	0.000	0.998	0.002
N48.9 Disorder of penis, unspecified	0.002	0.998	0.000
R50.8 Other specified fever	0.000	0.998	0.002
D86.3 Sarcoidosis of skin	0.002	0.998	0.000
D86 Sarcoidosis	0.002	0.998	0.000
D86.8 Sarcoidosis of other and combined sites	0.002	0.998	0.000
Z80.7 Family history of malignant neoplasms of lymphoid, haematopoietic and related tissues	0.000	0.998	0.002
R50.0 Fever with chills	0.000	0.998	0.002
C78.7 Secondary malignant neoplasm of liver	0.000	0.998	0.002
H90.0 Conductive hearing loss, bilateral	0.000	0.998	0.002
D83 Common variable immunodeficiency	0.002	0.998	0.000
R50 Fever of unknown origin	0.000	0.998	0.002
H90.2 Conductive hearing loss, unspecified	0.000	0.998	0.002
D32.0 Cerebral meninges	0.000	0.998	0.002
K31.8 Other specified diseases of stomach and duodenum	0.000	0.998	0.002
M93.9 Osteochondropathy, unspecified	0.002	0.998	0.000
D84 Other immunodeficiencies	0.002	0.998	0.000
D82 Immunodeficiency associated with other major defects	0.002	0.998	0.000
D81 Combined immunodeficiencies	0.002	0.998	0.000
T81.7 Vascular complications following a procedure, not elsewhere classified	0.000	0.998	0.002
L05.9 Pilonidal cyst without abscess	0.002	0.998	0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.000	0.998	0.002
D09.0 Bladder	0.000	0.998	0.002
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.002	0.998	0.000
D75.1 Secondary polycythaemia	0.002	0.998	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.002	0.998	0.000
H20.8 Other iridocyclitis	0.000	0.998	0.002
N48.8 Other specified disorders of penis	0.002	0.998	0.000
G31.2 Degeneration of nervous system due to alcohol	0.000	0.998	0.002
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.002	0.998	0.000
D83.9 Common variable immunodeficiency, unspecified	0.002	0.998	0.000
K41.3 Unilateral or unspecified femoral hernia, with obstruction, without gangrene	0.002	0.998	0.000
H90 Conductive and sensorineural hearing loss	0.000	0.998	0.002
S00.1 Contusion of eyelid and periocular area	0.002	0.998	0.000
G31.0 Circumscribed brain atrophy	0.000	0.998	0.002
N48.0 Leukoplakia of penis	0.002	0.998	0.000
D83.8 Other common variable immunodeficiencies	0.002	0.998	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.002	0.998	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.002	0.998	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.002	0.998	0.000
H20.0 Acute and subacute iridocyclitis	0.000	0.998	0.002
R50.2 Drug-induced fever	0.000	0.998	0.002
R50.1 Persistent fever	0.000	0.998	0.002
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.998	0.002
N43 Hydrocele and spermatocele	0.000	0.998	0.002
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.002	0.998	0.000
H02.0 Entropion and trichiasis of eyelid	0.000	0.998	0.002
N77.1 Vaginitis, vulvitis and vulvovaginitis in infectious and parasitic diseases classified elsewhere	0.002	0.998	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.002	0.998	0.000
D81.9 Combined immunodeficiency, unspecified	0.002	0.998	0.000
D81.8 Other combined immunodeficiencies	0.002	0.998	0.000
D81.7 Major histocompatibility complex class II deficiency	0.002	0.998	0.000
D81.6 Major histocompatibility complex class I deficiency	0.002	0.998	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.002	0.998	0.000
D81.4 Nezelof's syndrome	0.002	0.998	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.002	0.998	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.002	0.998	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.002	0.998	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.002	0.998	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.002	0.998	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.002	0.998	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.002	0.998	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.002	0.998	0.000
D82.2 Immunodeficiency with short-limbed stature	0.002	0.998	0.000
D82.1 Di George's syndrome	0.002	0.998	0.000
D82.0 Wiskott-Aldrich syndrome	0.002	0.998	0.000
D84.9 Immunodeficiency, unspecified	0.002	0.998	0.000
D84.8 Other specified immunodeficiencies	0.002	0.998	0.000
D84.1 Defects in the complement system	0.002	0.998	0.000
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.002	0.998	0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges	0.000	0.998	0.002
H72.8 Other perforations of tympanic membrane	0.002	0.998	0.000
G31.1 Senile degeneration of brain, not elsewhere classified	0.000	0.998	0.002
H90.5 Sensorineural hearing loss, unspecified	0.000	0.998	0.002
N85.1 Endometrial adenomatous hyperplasia	0.002	0.998	0.000
G40 Epilepsy	0.002	0.998	0.000
G31.9 Degenerative disease of nervous system, unspecified	0.000	0.998	0.002
O80.9 Single spontaneous delivery, unspecified	0.002	0.998	0.000
Z80.9 Family history of malignant neoplasm, unspecified	0.000	0.998	0.002
D86.1 Sarcoidosis of lymph nodes	0.002	0.998	0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.998	0.002
L05.0 Pilonidal cyst with abscess	0.002	0.998	0.000
Z99.8 Dependence on other enabling machines and devices	0.000	0.998	0.002
M24.27 Disorder of ligament (Ankle and foot)	0.002	0.998	0.000
G40.7 Petit mal, unspecified, without grand mal seizures	0.002	0.998	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.000	0.998	0.002
N43.4 Spermatocele	0.000	0.998	0.002
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.000	0.998	0.002
K41 Femoral hernia	0.002	0.998	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.002	0.998	0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures	0.002	0.998	0.000
I65.2 Occlusion and stenosis of carotid artery	0.002	0.998	0.000
D86.9 Sarcoidosis, unspecified	0.002	0.998	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.001	0.998	0.000
K50.0 Crohn's disease of small intestine	0.001	0.998	0.000
Z88.7 Personal history of allergy to serum and vaccine	0.000	0.998	0.002
C78.1 Secondary malignant neoplasm of mediastinum	0.000	0.998	0.002
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.001	0.998	0.000
D89.3 Immune reconstitution syndrome	0.001	0.998	0.000
D89.1 Cryoglobulinaemia	0.001	0.998	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.002	0.998	0.000
N43.2 Other hydrocele	0.000	0.998	0.001
N43.1 Infected hydrocele	0.000	0.998	0.001
N43.0 Encysted hydrocele	0.000	0.998	0.001
K51 Ulcerative colitis	0.002	0.998	0.000
R90 Abnormal findings on diagnostic imaging of central nervous system	0.002	0.998	0.000
M24.07 Loose body in joint (Ankle and foot)	0.002	0.998	0.000
M24.04 Loose body in joint (Hand)	0.001	0.998	0.000
F00.9 Dementia in Alzheimer's disease, unspecified	0.002	0.998	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.000	0.998	0.001
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures	0.002	0.998	0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.998	0.001
K51.9 Ulcerative colitis, unspecified	0.002	0.998	0.000
M24.2 Disorder of ligament	0.002	0.998	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.998	0.002
C78.5 Secondary malignant neoplasm of large intestine and rectum	0.000	0.998	0.002
G40.4 Other generalised epilepsy and epileptic syndromes	0.001	0.998	0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset	0.001	0.998	0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.000	0.998	0.002
H72 Perforation of tympanic membrane	0.002	0.998	0.000
M24.0 Loose body in joint	0.001	0.998	0.000
K50-K52 Noninfective enteritis and colitis	0.002	0.998	0.000
Z95.2 Presence of prosthetic heart valve	0.000	0.998	0.002
M24 Other specific joint derangements	0.002	0.998	0.000
M24.1 Other articular cartilage disorders	0.001	0.998	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.001	0.999	0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.001	0.999	0.000
K41.4 Unilateral or unspecified femoral hernia, with gangrene	0.001	0.999	0.000
K41.2 Bilateral femoral hernia, without obstruction or gangrene	0.001	0.999	0.000
K41.1 Bilateral femoral hernia, with gangrene	0.001	0.999	0.000
K41.0 Bilateral femoral hernia, with obstruction, without gangrene	0.001	0.999	0.000
T81.3 Disruption of operation wound, not elsewhere classified	0.000	0.999	0.001
M24.66 Ankylosis of joint (Lower leg)	0.001	0.999	0.000
G40.5 Special epileptic syndromes	0.001	0.999	0.000
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.001	0.999	0.000
M24.6 Ankylosis of joint	0.001	0.999	0.000
Z49.1 Extracorporeal dialysis	0.000	0.999	0.001
L05 Pilonidal cyst	0.001	0.999	0.000
M93 Other osteochondropathies	0.001	0.999	0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs	0.000	0.999	0.001
G40.8 Other epilepsy	0.001	0.999	0.000
K60.1 Chronic anal fissure	0.000	0.999	0.001
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.001	0.999	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.001	0.999	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.001	0.999	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.001	0.999	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.001	0.999	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.001	0.999	0.000
K42.0 Umbilical hernia with obstruction, without gangrene	0.000	0.999	0.001
K51.1 Ulcerative (chronic) ileocolitis	0.001	0.999	0.000
M24.21 Disorder of ligament (Shoulder region)	0.001	0.999	0.000
M24.37 Pathological dislocation and subluxation of joint, not elsewhere classified (Ankle and foot)	0.001	0.999	0.000
R90.0 Intracranial space-occupying lesion	0.001	0.999	0.000
S50.9 Superficial injury of forearm, unspecified	0.000	0.999	0.001
H20 Iridocyclitis	0.000	0.999	0.001
M24.13 Other articular cartilage disorders (Forearm)	0.001	0.999	0.000
M24.29 Disorder of ligament (Site unspecified)	0.001	0.999	0.000
M24.25 Disorder of ligament (Pelvic region and thigh)	0.001	0.999	0.000
M24.22 Disorder of ligament (Upper arm)	0.001	0.999	0.000
M24.20 Disorder of ligament (Multiple sites)	0.001	0.999	0.000
D86.0 Sarcoidosis of lung	0.001	0.999	0.000
K91.3 Postoperative intestinal obstruction	0.000	0.999	0.001
M24.28 Disorder of ligament (Other)	0.001	0.999	0.000
M94.89 Other specified disorders of cartilage (Site unspecified)	0.001	0.999	0.000
C15.5 Lower third of oesophagus	0.001	0.999	0.000
K51.5 Mucosal proctocolitis	0.001	0.999	0.000
K51.3 Ulcerative (chronic) rectosigmoiditis	0.001	0.999	0.000
O82 Single delivery by Caesarean section	0.000	0.999	0.001
M24.09 Loose body in joint (Site unspecified)	0.001	0.999	0.000
M24.08 Loose body in joint (Other)	0.001	0.999	0.000
M24.06 Loose body in joint-Lower leg	0.001	0.999	0.000
M24.05 Loose body in joint (Pelvic region and thigh)	0.001	0.999	0.000
M24.03 Loose body in joint (Forearm)	0.001	0.999	0.000
M24.00 Loose body in joint (Multiple sites)	0.001	0.999	0.000
M24.24 Disorder of ligament (Hand)	0.001	0.999	0.000
H72.1 Attic perforation of tympanic membrane	0.001	0.999	0.000
Z35.8 Supervision of other high-risk pregnancies	0.001	0.999	0.000
M24.19 Other articular cartilage disorders (Site unspecified)	0.001	0.999	0.000
M24.18 Other articular cartilage disorders (Other)	0.001	0.999	0.000
M24.14 Other articular cartilage disorders (Hand)	0.001	0.999	0.000
M24.12 Other articular cartilage disorders (Upper arm)	0.001	0.999	0.000
M24.10 Other articular cartilage disorders (Multiple sites)	0.001	0.999	0.000
M94.86 Other specified disorders of cartilage (Lower leg)	0.001	0.999	0.000
D36.0 Lymph nodes	0.000	0.999	0.001
F60.6 Anxious [avoidant] personality disorder	0.001	0.999	0.000
F81.9 Developmental disorder of scholastic skills, unspecified	0.001	0.999	0.000
M24.9 Joint derangement, unspecified	0.001	0.999	0.000
N04.9 Unspecified	0.000	0.999	0.001
D36 Benign neoplasm of other and unspecified sites	0.000	0.999	0.001
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.001	0.999	0.000
F60.0 Paranoid personality disorder	0.001	0.999	0.000
Z35.1 Supervision of pregnancy with history of abortive outcome	0.001	0.999	0.000
M24.01 Loose body in joint (Shoulder region)	0.001	0.999	0.000
M24.23 Disorder of ligament (Forearm)	0.001	0.999	0.000
M24.69 Ankylosis of joint (Site unspecified)	0.001	0.999	0.000
M24.68 Ankylosis of joint (Other)	0.001	0.999	0.000
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.001	0.999	0.000
M24.64 Ankylosis of joint (Hand)	0.001	0.999	0.000
M24.63 Ankylosis of joint (Forearm)	0.001	0.999	0.000
M24.62 Ankylosis of joint (Upper arm)	0.001	0.999	0.000
M24.61 Ankylosis of joint (Shoulder region)	0.001	0.999	0.000
M24.60 Ankylosis of joint (Multiple sites)	0.001	0.999	0.000
C81.9 Hodgkin's disease, unspecified	0.000	0.999	0.001
M93.8 Other specified osteochondropathies	0.001	0.999	0.000
M93.2 Osteochondritis dissecans	0.001	0.999	0.000
M93.1 Kienbock's disease of adults	0.001	0.999	0.000
M93.0 Slipped upper femoral epiphysis (nontraumatic)	0.001	0.999	0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.001	0.999	0.000
M24.39 Pathological dislocation and subluxation of joint, not elsewhere classified (Site unspecified)	0.001	0.999	0.000
M24.38 Pathological dislocation and subluxation of joint, not elsewhere classified (Other)	0.001	0.999	0.000
M24.36 Pathological dislocation and subluxation of joint, not elsewhere classified (Lower leg)	0.001	0.999	0.000
M24.35 Pathological dislocation and subluxation of joint, not elsewhere classified (Pelvic region and thigh)	0.001	0.999	0.000
M24.34 Pathological dislocation and subluxation of joint, not elsewhere classified (Hand)	0.001	0.999	0.000
M24.33 Pathological dislocation and subluxation of joint, not elsewhere classified (Forearm)	0.001	0.999	0.000
M24.32 Pathological dislocation and subluxation of joint, not elsewhere classified (Upper arm)	0.001	0.999	0.000
M24.31 Pathological dislocation and subluxation of joint, not elsewhere classified (Shoulder region)	0.001	0.999	0.000
M24.30 Pathological dislocation and subluxation of joint, not elsewhere classified (Multiple sites)	0.001	0.999	0.000
M94.85 Other specified disorders of cartilage (Pelvic region and thigh)	0.001	0.999	0.000
B37.9 Candidiasis, unspecified	0.001	0.999	0.000
F52.2 Failure of genital response	0.001	0.999	0.000
M94.8 Other specified disorders of cartilage	0.001	0.999	0.000
Z50.8 Care involving use of rehabilitation procedures	0.000	0.999	0.001
M24.26 Disorder of ligament (Lower leg)	0.001	0.999	0.000
M62.86 Other specified disorders of muscle (Lower leg)	0.001	0.999	0.000
H20.2 Lens-induced iridocyclitis	0.000	0.999	0.001
M24.7 Protrusio acetabuli	0.001	0.999	0.000
M24.44 Recurrent dislocation and subluxation of joint (Hand)	0.001	0.999	0.000
M24.67 Ankylosis of joint (Ankle and foot)	0.001	0.999	0.000
M94.96 Disorder of cartilage, unspecified (Lower leg)	0.001	0.999	0.000
T84.0 Mechanical complication of internal joint prosthesis	0.001	0.999	0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs	0.000	0.999	0.001
M24.5 Contracture of joint	0.001	0.999	0.000
O82.8 Other single delivery by Caesarean section	0.000	0.999	0.001
O82.2 Delivery by Caesarean hysterectomy	0.000	0.999	0.001
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.999	0.001
M24.17 Other articular cartilage disorders (Ankle and foot)	0.001	0.999	0.000
M24.51 Contracture of joint (Shoulder region)	0.001	0.999	0.000
M24.99 Joint derangement, unspecified (Site unspecified)	0.001	0.999	0.000
M24.98 Joint derangement, unspecified (Other)	0.001	0.999	0.000
M24.97 Joint derangement, unspecified (Ankle and foot)	0.001	0.999	0.000
M24.96 Joint derangement, unspecified (Lower leg)	0.001	0.999	0.000
M24.95 Joint derangement, unspecified (Pelvic region and thigh)	0.001	0.999	0.000
M24.94 Joint derangement, unspecified (Hand)	0.001	0.999	0.000
M24.93 Joint derangement, unspecified (Forearm)	0.001	0.999	0.000
M24.92 Joint derangement, unspecified (Upper arm)	0.001	0.999	0.000
M24.91 Joint derangement, unspecified (Shoulder region)	0.001	0.999	0.000
M24.90 Joint derangement, unspecified (Multiple sites)	0.001	0.999	0.000
M62.08 Diastasis of muscle (Other)	0.001	0.999	0.000
M62.56 Muscle wasting and atrophy, not elsewhere classified (Lower leg)	0.001	0.999	0.000
M62.89 Other specified disorders of muscle (Site unspecified)	0.001	0.999	0.000
D36.9 Benign neoplasm of unspecified site	0.000	0.999	0.001
M24.11 Other articular cartilage disorders (Shoulder region)	0.001	0.999	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.001	0.999	0.000
M62.15 Other rupture of muscle (nontraumatic) (Pelvic region and thigh)	0.001	0.999	0.000
M93.26 Osteochondritis dissecans knee	0.001	0.999	0.000
M93.86 Other specified osteochondropathies, lower leg	0.001	0.999	0.000
S82.10 Fracture of upper end of tibia (closed)	0.000	0.999	0.001
F60.9 Personality disorder, unspecified	0.001	0.999	0.000
H01.0 Blepharitis	0.000	0.999	0.001
M24.4 Recurrent dislocation and subluxation of joint	0.001	0.999	0.000
M62.8 Other specified disorders of muscle	0.001	0.999	0.000
M95.9 Acquired deformity of musculoskeletal system, unspecified	0.001	0.999	0.000
M95.8 Other specified acquired deformities of musculoskeletal system	0.001	0.999	0.000
M95.5 Acquired deformity of pelvis	0.001	0.999	0.000
M95.3 Acquired deformity of neck	0.001	0.999	0.000
M95.1 Cauliflower ear	0.001	0.999	0.000
F60 Specific personality disorders	0.001	0.999	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations