TreeWAS – Variant ID: rs4888966

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
D70 Agranulocytosis	0.000	0.892	0.108
D70-D77 Other diseases of blood and blood-forming organs	0.000	0.924	0.076
D73 Diseases of spleen	0.000	0.935	0.065
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.000	0.945	0.055
D74 Methaemoglobinaemia	0.000	0.945	0.055
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.000	0.945	0.055
D71 Functional disorders of polymorphonuclear neutrophils	0.000	0.945	0.055
D75 Other diseases of blood and blood-forming organs	0.000	0.948	0.052
D73.8 Other diseases of spleen	0.000	0.949	0.051
D73.5 Infarction of spleen	0.000	0.949	0.050
D73.0 Hyposplenism	0.000	0.950	0.050
D73.4 Cyst of spleen	0.000	0.950	0.050
D72 Other disorders of white blood cells	0.000	0.952	0.048
D73.3 Abscess of spleen	0.000	0.952	0.048
D73.1 Hypersplenism	0.000	0.952	0.048
D73.2 Chronic congestive splenomegaly	0.000	0.953	0.047
D73.9 Disease of spleen, unspecified	0.000	0.953	0.046
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.000	0.954	0.046
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.000	0.957	0.043
D75.8 Other specified diseases of blood and blood-forming organs	0.000	0.959	0.041
D76.3 Other histiocytosis syndromes	0.000	0.960	0.040
D76.2 Haemophagocytic syndrome, infection-associated	0.000	0.960	0.040
D76.1 Haemophagocytic lymphohistiocytosis	0.000	0.960	0.040
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.000	0.960	0.040
D74.9 Methaemoglobinaemia, unspecified	0.000	0.960	0.039
D74.8 Other methaemoglobinaemias	0.000	0.960	0.039
D74.0 Congenital methaemoglobinaemia	0.000	0.960	0.039
D68 Other coagulation defects	0.000	0.962	0.038
D80-D89 Certain disorders involving the immune mechanism	0.000	0.962	0.038
D75.0 Familial erythrocytosis	0.000	0.962	0.038
D75.2 Essential thrombocytosis	0.000	0.963	0.036
D69 Purpura and other haemorrhagic conditions	0.000	0.964	0.036
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.000	0.964	0.036
D72.9 Disorder of white blood cells, unspecified	0.000	0.965	0.035
D72.0 Genetic anomalies of leukocytes	0.000	0.965	0.035
D72.1 Eosinophilia	0.000	0.965	0.035
D75.9 Disease of blood and blood-forming organs, unspecified	0.000	0.965	0.035
D75.1 Secondary polycythaemia	0.000	0.965	0.035
D68.9 Coagulation defect, unspecified	0.000	0.967	0.033
D86 Sarcoidosis	0.000	0.967	0.033
D66 Hereditary factor VIII deficiency	0.000	0.968	0.032
D68.2 Hereditary deficiency of other clotting factors	0.000	0.968	0.032
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.000	0.969	0.031
D67 Hereditary factor IX deficiency	0.000	0.969	0.031
D69.6 Thrombocytopenia, unspecified	0.000	0.970	0.030
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.000	0.971	0.029
D55-D59 Haemolytic anaemias	0.000	0.971	0.029
D60-D64 Aplastic and other anaemias	0.000	0.971	0.029
D69.0 Allergic purpura	0.000	0.971	0.029
D68.0 Von Willebrand's disease	0.000	0.971	0.029
D80 Immunodeficiency with predominantly antibody defects	0.000	0.971	0.028
D68.1 Hereditary factor XI deficiency	0.000	0.972	0.028
D72.8 Other specified disorders of white blood cells	0.000	0.972	0.028
D69.9 Haemorrhagic condition, unspecified	0.000	0.972	0.028
D83 Common variable immunodeficiency	0.000	0.972	0.028
D81 Combined immunodeficiencies	0.000	0.972	0.027
D69.4 Other primary thrombocytopenia	0.000	0.973	0.027
D68.4 Acquired coagulation factor deficiency	0.000	0.973	0.027
D68.8 Other specified coagulation defects	0.000	0.973	0.027
D86.9 Sarcoidosis, unspecified	0.000	0.973	0.027
D82 Immunodeficiency associated with other major defects	0.000	0.973	0.027
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.000	0.973	0.027
D86.1 Sarcoidosis of lymph nodes	0.000	0.973	0.027
D68.6 Other Thrombophilia	0.000	0.973	0.027
D84 Other immunodeficiencies	0.000	0.973	0.027
D69.2 Other nonthrombocytopenic purpura	0.000	0.973	0.027
D69.5 Secondary thrombocytopenia	0.000	0.974	0.026
D69.8 Other specified haemorrhagic conditions	0.000	0.974	0.026
D69.1 Qualitative platelet defects	0.000	0.974	0.026
D68.5 Primary Thrombophilia	0.000	0.974	0.025
D50-D53 Nutritional anaemias	0.000	0.975	0.025
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.000	0.976	0.024
D69.3 Idiopathic thrombocytopenic purpura	0.000	0.976	0.024
D86.3 Sarcoidosis of skin	0.000	0.976	0.024
D86.0 Sarcoidosis of lung	0.000	0.976	0.024
D86.8 Sarcoidosis of other and combined sites	0.000	0.977	0.023
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.000	0.978	0.022
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.000	0.978	0.022
D61 Other aplastic anaemias	0.000	0.978	0.022
D62 Acute posthaemorrhagic anaemia	0.000	0.978	0.022
D55 Anaemia due to enzyme disorders	0.000	0.979	0.021
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.000	0.979	0.021
D89.1 Cryoglobulinaemia	0.000	0.979	0.021
D56 Thalassaemia	0.000	0.979	0.021
D57 Sickle-cell disorders	0.000	0.979	0.021
D80.7 Transient hypogammaglobulinaemia of infancy	0.000	0.979	0.021
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.000	0.979	0.021
D80.0 Hereditary hypogammaglobulinaemia	0.000	0.979	0.021
D80.8 Other immunodeficiencies with predominantly antibody defects	0.000	0.979	0.020
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.000	0.979	0.020
D63 Anaemia in chronic diseases classified elsewhere	0.000	0.979	0.020
D83.9 Common variable immunodeficiency, unspecified	0.000	0.980	0.020
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.000	0.980	0.020
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.000	0.980	0.020
D83.8 Other common variable immunodeficiencies	0.000	0.980	0.020
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.000	0.980	0.020
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.000	0.980	0.020
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.000	0.980	0.020
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.000	0.980	0.020
D81.9 Combined immunodeficiency, unspecified	0.000	0.980	0.020
D81.8 Other combined immunodeficiencies	0.000	0.980	0.020
D81.7 Major histocompatibility complex class II deficiency	0.000	0.980	0.020
D81.6 Major histocompatibility complex class I deficiency	0.000	0.980	0.020
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.000	0.980	0.020
D81.4 Nezelof's syndrome	0.000	0.980	0.020
D81.3 Adenosine deaminase [ADA] deficiency	0.000	0.980	0.020
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.000	0.980	0.020
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.000	0.980	0.020
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.000	0.980	0.020
D82.9 Immunodeficiency associated with major defect, unspecified	0.000	0.980	0.019
D82.8 Immunodeficiency associated with other specified major defects	0.000	0.980	0.019
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.000	0.980	0.019
D82.2 Immunodeficiency with short-limbed stature	0.000	0.980	0.019
D82.0 Wiskott-Aldrich syndrome	0.000	0.980	0.019
D59 Acquired haemolytic anaemia	0.000	0.980	0.019
D89.3 Immune reconstitution syndrome	0.000	0.980	0.019
D80.1 Nonfamilial hypogammaglobulinaemia	0.000	0.980	0.019
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.000	0.980	0.019
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.000	0.980	0.019
D58 Other hereditary haemolytic anaemias	0.000	0.980	0.019
D84.9 Immunodeficiency, unspecified	0.000	0.981	0.019
D82.1 Di George's syndrome	0.000	0.981	0.019
D84.8 Other specified immunodeficiencies	0.000	0.981	0.019
D89.0 Polyclonal hypergammaglobulinaemia	0.000	0.981	0.019
D84.1 Defects in the complement system	0.000	0.981	0.019
D89.9 Disorder involving the immune mechanism, unspecified	0.000	0.981	0.019
D51 Vitamin B12 deficiency anaemia	0.000	0.981	0.019
D89.2 Hypergammaglobulinaemia, unspecified	0.000	0.982	0.018
D52 Folate deficiency anaemia	0.000	0.982	0.018
D53 Other nutritional anaemias	0.000	0.982	0.018
D61.0 Constitutional aplastic anaemia	0.000	0.982	0.017
D61.1 Drug-induced aplastic anaemia	0.000	0.983	0.017
D61.8 Other specified aplastic anaemias	0.000	0.984	0.016
D61.3 Idiopathic aplastic anaemia	0.000	0.984	0.016
D61.2 Aplastic anaemia due to other external agents	0.000	0.984	0.016
D56.9 Thalassaemia, unspecified	0.000	0.984	0.015
D55.9 Anaemia due to enzyme disorder, unspecified	0.000	0.985	0.015
D55.8 Other anaemias due to enzyme disorders	0.000	0.985	0.015
D55.3 Anaemia due to disorders of nucleotide metabolism	0.000	0.985	0.015
D55.2 Anaemia due to disorders of glycolytic enzymes	0.000	0.985	0.015
D55.1 Anaemia due to other disorders of glutathione metabolism	0.000	0.985	0.015
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.000	0.985	0.015
D63.0 Anaemia in neoplastic disease	0.000	0.985	0.015
D60.8 Other acquired pure red cell aplasias	0.000	0.985	0.015
D60.1 Transient acquired pure red cell aplasia	0.000	0.985	0.015
D60.0 Chronic acquired pure red cell aplasia	0.000	0.985	0.015
D64 Other anaemias	0.000	0.985	0.015
H90-H95 Other disorders of ear	0.000	0.985	0.015
D56.8 Other thalassaemias	0.000	0.985	0.015
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.000	0.985	0.015
D56.2 Delta-beta thalassaemia	0.000	0.985	0.015
D56.0 Alpha thalassaemia	0.000	0.985	0.015
D57.8 Other sickle-cell disorders	0.000	0.985	0.015
D57.2 Double heterozygous sickling disorders	0.000	0.985	0.015
D57.0 Sickle-cell anaemia with crisis	0.000	0.985	0.015
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.000	0.985	0.015
D60.9 Acquired pure red cell aplasia, unspecified	0.000	0.985	0.015
D57.3 Sickle-cell trait	0.000	0.985	0.015
D57.1 Sickle-cell anaemia without crisis	0.000	0.985	0.015
D63.1 Anaemia in other chronic diseases classified elsewhere	0.000	0.985	0.015
D56.1 Beta thalassaemia	0.000	0.985	0.015
D59.4 Other nonautoimmune haemolytic anaemias	0.000	0.985	0.014
H90 Conductive and sensorineural hearing loss	0.000	0.985	0.015
D56.3 Thalassaemia trait	0.000	0.985	0.014
I83 Varicose veins of lower extremities	0.000	0.985	0.015
D59.8 Other acquired haemolytic anaemias	0.000	0.986	0.014
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.000	0.986	0.014
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.000	0.986	0.014
D59.3 Haemolytic-uraemic syndrome	0.000	0.986	0.014
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.000	0.986	0.014
D59.0 Drug-induced autoimmune haemolytic anaemia	0.000	0.986	0.014
D58.8 Other specified hereditary haemolytic anaemias	0.000	0.986	0.014
D58.1 Hereditary elliptocytosis	0.000	0.986	0.014
D61.9 Aplastic anaemia, unspecified	0.000	0.986	0.014
Chapter VIII Diseases of the ear and mastoid process	0.000	0.986	0.014
D58.2 Other haemoglobinopathies	0.000	0.986	0.014
D63.8 Anaemia in other chronic diseases classified elsewhere	0.000	0.986	0.014
D59.9 Acquired haemolytic anaemia, unspecified	0.000	0.986	0.013
H65-H75 Diseases of middle ear and mastoid	0.000	0.986	0.014
H60-H62 Diseases of external ear	0.000	0.986	0.014
D51.2 Transcobalamin II deficiency	0.000	0.986	0.014
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.000	0.986	0.014
D51.8 Other vitamin B12 deficiency anaemias	0.000	0.986	0.013
D58.9 Hereditary haemolytic anaemia, unspecified	0.000	0.986	0.013
D51.3 Other dietary vitamin B12 deficiency anaemia	0.000	0.986	0.013
D58.0 Hereditary spherocytosis	0.000	0.986	0.013
H90.3 Sensorineural hearing loss, bilateral	0.000	0.986	0.014
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.000	0.987	0.013
D59.1 Other autoimmune haemolytic anaemias	0.000	0.987	0.013
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.000	0.987	0.013
H93 Other disorders of ear, not elsewhere classified	0.000	0.987	0.013
D52.8 Other folate deficiency anaemias	0.000	0.987	0.013
D52.1 Drug-induced folate deficiency anaemia	0.000	0.987	0.013
D52.0 Dietary folate deficiency anaemia	0.000	0.987	0.013
D53.8 Other specified nutritional anaemias	0.000	0.987	0.013
D53.2 Scorbutic anaemia	0.000	0.987	0.013
D53.0 Protein deficiency anaemia	0.000	0.987	0.013
D52.9 Folate deficiency anaemia, unspecified	0.000	0.987	0.013
H60 Otitis externa	0.000	0.987	0.013
H92 Otalgia and effusion of ear	0.000	0.987	0.012
H74 Other disorders of middle ear and mastoid	0.000	0.987	0.013
H90.2 Conductive hearing loss, unspecified	0.000	0.987	0.012
D64.8 Other specified anaemias	0.000	0.988	0.012
H91 Other hearing loss	0.000	0.988	0.012
D53.9 Nutritional anaemia, unspecified	0.000	0.988	0.012
H65 Nonsuppurative otitis media	0.000	0.988	0.012
H61 Other disorders of external ear	0.000	0.988	0.012
H90.5 Sensorineural hearing loss, unspecified	0.000	0.988	0.012
H60.9 Otitis externa, unspecified	0.000	0.988	0.012
H65.3 Chronic mucoid otitis media	0.000	0.988	0.012
H74.8 Other specified disorders of middle ear and mastoid	0.000	0.988	0.011
H90.0 Conductive hearing loss, bilateral	0.000	0.989	0.011
D64.4 Congenital dyserythropoietic anaemia	0.000	0.989	0.011
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.000	0.989	0.011
D64.1 Secondary sideroblastic anaemia due to disease	0.000	0.989	0.011
H94 Other disorders of ear in diseases classified elsewhere	0.000	0.989	0.011
H92.1 Otorrhoea	0.000	0.989	0.011
D64.0 Hereditary sideroblastic anaemia	0.000	0.989	0.011
D64.3 Other sideroblastic anaemias	0.000	0.989	0.011
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.000	0.989	0.011
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.000	0.989	0.011
H93.1 Tinnitus	0.000	0.989	0.011
H73 Other disorders of tympanic membrane	0.000	0.989	0.011
H72 Perforation of tympanic membrane	0.000	0.989	0.011
H69 Other disorders of Eustachian tube	0.000	0.989	0.011
H61.0 Perichondritis of external ear	0.000	0.989	0.011
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.000	0.989	0.010
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.989	0.010
H93.8 Other specified disorders of ear	0.000	0.990	0.010
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.990	0.010
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.000	0.990	0.010
H61.3 Acquired stenosis of external ear canal	0.000	0.990	0.010
H93.3 Disorders of acoustic nerve	0.000	0.990	0.010
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.000	0.990	0.010
H67 Otitis media in diseases classified elsewhere	0.000	0.990	0.010
H70 Mastoiditis and related conditions	0.000	0.990	0.010
H91.9 Hearing loss, unspecified	0.000	0.990	0.010
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.000	0.990	0.010
H68 Eustachian salpingitis and obstruction	0.000	0.990	0.010
I83.0 Varicose veins of lower extremities with ulcer	0.000	0.990	0.010
H62 Disorders of external ear in diseases classified elsewhere	0.000	0.990	0.010
H93.2 Other abnormal auditory perceptions	0.000	0.990	0.010
H66 Suppurative and unspecified otitis media	0.000	0.990	0.010
H72.9 Perforation of tympanic membrane, unspecified	0.000	0.990	0.010
H91.1 Presbycusis	0.000	0.990	0.010
H74.9 Disorder of middle ear and mastoid, unspecified	0.000	0.990	0.010
H93.0 Degenerative and vascular disorders of ear	0.000	0.990	0.010
H60.3 Other infective otitis externa	0.000	0.990	0.009
H93.9 Disorder of ear, unspecified	0.000	0.990	0.009
H60.1 Cellulitis of external ear	0.000	0.990	0.009
H60.0 Abscess of external ear	0.000	0.990	0.009
H80-H83 Diseases of inner ear	0.000	0.991	0.009
H74.4 Polyp of middle ear	0.000	0.991	0.009
I83.1 Varicose veins of lower extremities with inflammation	0.000	0.991	0.009
H61.8 Other specified disorders of external ear	0.000	0.991	0.009
H74.2 Discontinuity and dislocation of ear ossicles	0.000	0.991	0.009
H65.2 Chronic serous otitis media	0.000	0.991	0.009
H60.5 Acute otitis externa, non-infective	0.000	0.991	0.009
H74.1 Adhesive middle ear disease	0.000	0.991	0.009
H60.8 Other otitis externa	0.000	0.991	0.009
H65.0 Acute serous otitis media	0.000	0.991	0.009
H60.2 Malignant otitis externa	0.000	0.991	0.009
H61.9 Disorder of external ear, unspecified	0.000	0.991	0.009
H65.9 Nonsuppurative otitis media, unspecified	0.000	0.991	0.009
H91.8 Other specified hearing loss	0.000	0.991	0.009
H74.3 Other acquired abnormalities of ear ossicles	0.000	0.991	0.009
H92.2 Otorrhagia	0.000	0.991	0.009
H69.8 Other specified disorders of Eustachian tube	0.000	0.991	0.009
H91.0 Ototoxic hearing loss	0.000	0.991	0.009
H74.0 Tympanosclerosis	0.000	0.991	0.009
H60.4 Cholesteatoma of external ear	0.000	0.991	0.009
H61.1 Non-infective disorders of pinna	0.000	0.991	0.009
H65.1 Other acute nonsuppurative otitis media	0.000	0.991	0.009
H91.2 Sudden idiopathic hearing loss	0.000	0.991	0.009
H91.3 Deaf mutism, not elsewhere classified	0.000	0.991	0.009
H40.9 Glaucoma, unspecified	0.000	0.991	0.009
D50 Iron deficiency anaemia	0.000	0.991	0.009
H73.0 Acute myringitis	0.000	0.991	0.008
H92.0 Otalgia	0.000	0.991	0.008
H65.4 Other chronic nonsuppurative otitis media	0.000	0.991	0.008
H73.9 Disorder of tympanic membrane, unspecified	0.000	0.992	0.008
H61.2 Impacted cerumen	0.000	0.992	0.008
H94.8 Other specified disorders of ear in diseases classified elsewhere	0.000	0.992	0.008
H94.0 Acoustic neuritis in infectious and parasitic diseases classified elsewhere	0.000	0.992	0.008
H73.8 Other specified disorders of tympanic membrane	0.000	0.992	0.008
H72.2 Other marginal perforations of tympanic membrane	0.000	0.992	0.008
H69.0 Patulous Eustachian tube	0.000	0.992	0.008
H73.1 Chronic myringitis	0.000	0.992	0.008
H71 Cholesteatoma of middle ear	0.000	0.992	0.008
H72.1 Attic perforation of tympanic membrane	0.000	0.992	0.008
H70.1 Chronic mastoiditis	0.000	0.992	0.007
H66.1 Chronic tubotympanic suppurative otitis media	0.000	0.992	0.008
H70.9 Mastoiditis, unspecified	0.000	0.992	0.007
H67.8 Otitis media in other diseases classified elsewhere	0.000	0.992	0.007
H67.1 Otitis media in viral diseases classified elsewhere	0.000	0.992	0.007
H67.0 Otitis media in bacterial diseases classified elsewhere	0.000	0.992	0.007
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere	0.000	0.992	0.007
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere	0.000	0.992	0.007
H69.9 Eustachian tube disorder, unspecified	0.000	0.992	0.007
H70.2 Petrositis	0.000	0.992	0.007
H66.0 Acute suppurative otitis media	0.000	0.992	0.007
H68.0 Eustachian salpingitis	0.000	0.992	0.007
H70.0 Acute mastoiditis	0.000	0.992	0.007
H62.8 Other disorders of external ear in diseases classified elsewhere	0.000	0.992	0.007
H62.4 Otitis externa in other diseases classified elsewhere	0.000	0.992	0.007
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere	0.000	0.992	0.007
H62.2 Otitis externa in mycoses	0.000	0.992	0.007
H62.1 Otitis externa in viral diseases classified elsewhere	0.000	0.992	0.007
H72.8 Other perforations of tympanic membrane	0.000	0.992	0.007
H95.9 Postprocedural disorder of ear and mastoid process, unspecified	0.000	0.992	0.007
H95.8 Other postprocedural disorders of ear and mastoid process	0.000	0.993	0.007
H70.8 Other mastoiditis and related conditions	0.000	0.993	0.007
H68.1 Obstruction of Eustachian tube	0.000	0.993	0.007
H62.0 Otitis externa in bacterial diseases classified elsewhere	0.000	0.993	0.007
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity	0.000	0.993	0.007
H66.2 Chronic atticoantral suppurative otitis media	0.000	0.993	0.007
H72.0 Central perforation of tympanic membrane	0.000	0.993	0.007
H66.9 Otitis media, unspecified	0.000	0.993	0.007
H66.3 Other chronic suppurative otitis media	0.000	0.993	0.007
H66.4 Suppurative otitis media, unspecified	0.000	0.993	0.007
H81 Disorders of vestibular function	0.000	0.993	0.007
H82 Vertiginous syndromes in diseases classified elsewhere	0.000	0.993	0.007
H95.1 Other disorders following mastoidectomy	0.000	0.993	0.007
H80 Otosclerosis	0.000	0.993	0.006
H83 Other diseases of inner ear	0.000	0.993	0.006
D50.1 Sideropenic dysphagia	0.000	0.994	0.006
M51.2 Other specified intervertebral disk displacement	0.000	0.994	0.006
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.000	0.994	0.006
H81.1 Benign paroxysmal vertigo	0.000	0.994	0.005
J34.2 Deviated nasal septum	0.000	0.994	0.006
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.000	0.994	0.006
H81.0 Meniere's disease	0.000	0.995	0.005
H81.2 Vestibular neuronitis	0.000	0.995	0.005
D50.8 Other iron deficiency anaemias	0.000	0.995	0.005
H81.4 Vertigo of central origin	0.000	0.995	0.005
H81.9 Disorder of vestibular function, unspecified	0.000	0.995	0.005
H81.8 Other disorders of vestibular function	0.000	0.995	0.005
H81.3 Other peripheral vertigo	0.000	0.995	0.005
H83.2 Labyrinthine dysfunction	0.000	0.995	0.005
H80.2 Cochlear otosclerosis	0.000	0.995	0.005
H80.1 Otosclerosis involving oval window, obliterative	0.000	0.995	0.005
H80.8 Other otosclerosis	0.000	0.995	0.005
H80.0 Otosclerosis involving oval window, nonobliterative	0.000	0.995	0.005
H83.1 Labyrinthine fistula	0.000	0.995	0.005
H83.3 Noise effects on inner ear	0.000	0.995	0.005
H83.9 Disease of inner ear, unspecified	0.000	0.995	0.005
I82 Other venous embolism and thrombosis	0.000	0.995	0.005
H83.8 Other specified diseases of inner ear	0.000	0.995	0.005
M51 Other intervertebral disk disorders	0.000	0.995	0.005
H80.9 Otosclerosis, unspecified	0.000	0.995	0.004
I80 Phlebitis and thrombophlebitis	0.000	0.995	0.005
H83.0 Labyrinthitis	0.000	0.995	0.004
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.000	0.995	0.004
I88 Nonspecific lymphadenitis	0.000	0.996	0.004
I86 Varicose veins of other sites	0.000	0.996	0.004
K04.7 Periapical abscess without sinus	0.000	0.996	0.004
I87 Other disorders of veins	0.000	0.996	0.004
M51.8 Other specified intervertebral disk disorders	0.000	0.996	0.004
I82.8 Embolism and thrombosis of other specified veins	0.000	0.996	0.004
I85 Oesophageal varices	0.000	0.996	0.004
I80.8 Phlebitis and thrombophlebitis of other sites	0.000	0.996	0.004
I82.9 Embolism and thrombosis of unspecified vein	0.000	0.996	0.004
I81 Portal vein thrombosis	0.000	0.996	0.004
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.000	0.996	0.004
E66.9 Obesity, unspecified	0.000	0.996	0.004
M54 Dorsalgia	0.000	0.996	0.004
I89.0 Lymphoedema, not elsewhere classified	0.000	0.996	0.004
I82.3 Embolism and thrombosis of renal vein	0.000	0.996	0.004
M51.3 Other specified intervertebral disk degeneration	0.000	0.996	0.004
I82.1 Thrombophlebitis migrans	0.000	0.996	0.004
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified	0.000	0.996	0.004
M50-M54 Other dorsopathies	0.000	0.996	0.004
I82.2 Embolism and thrombosis of vena cava	0.000	0.996	0.004
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.000	0.996	0.004
I82.0 Budd-Chiari syndrome	0.000	0.996	0.004
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.000	0.996	0.004
I86.8 Varicose veins of other specified sites	0.000	0.996	0.003
I88.0 Nonspecific mesenteric lymphadenitis	0.000	0.996	0.003
M51.4 Schmorl's nodes	0.000	0.996	0.003
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.000	0.996	0.003
I88.1 Chronic lymphadenitis, except mesenteric	0.000	0.996	0.003
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes	0.000	0.996	0.003
M51.0 Lumbar and other intervertebral disk disorders with myelopathy	0.000	0.996	0.003
M54.3 Sciatica	0.000	0.996	0.003
I87.8 Other specified disorders of veins	0.000	0.997	0.003
I87.0 Postphlebitic syndrome	0.000	0.997	0.003
I86.1 Scrotal varices	0.000	0.997	0.003
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.000	0.997	0.003
M54.4 Lumbago with sciatica	0.000	0.997	0.003
I86.0 Sublingual varices	0.000	0.997	0.003
I86.4 Gastric varices	0.000	0.997	0.003
I87.1 Compression of vein	0.000	0.997	0.003
I88.8 Other nonspecific lymphadenitis	0.000	0.997	0.003
I89.1 Lymphangitis	0.000	0.997	0.003
M54.39 Sciatica (Site unspecified)	0.000	0.997	0.003
I86.3 Vulval varices	0.000	0.997	0.003
I88.9 Nonspecific lymphadenitis, unspecified	0.000	0.997	0.003
M51.9 Intervertebral disk disorder, unspecified	0.000	0.997	0.003
I86.2 Pelvic varices	0.000	0.997	0.003
I87.9 Disorder of vein, unspecified	0.000	0.997	0.003
M54.6 Pain in thoracic spine	0.000	0.997	0.003
K04 Diseases of pulp and periapical tissues	0.000	0.997	0.003
I87.2 Venous insufficiency (chronic) (peripheral)	0.000	0.997	0.003
M54.5 Low back pain	0.000	0.997	0.003
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.000	0.997	0.003
M50.1 Cervical disk disorder with radiculopathy	0.000	0.997	0.003
M50 Cervical disk disorders	0.000	0.997	0.003
M54.46 Lumbago with sciatica (Lumbar region)	0.000	0.997	0.003
I85.9 Oesophageal varices without bleeding	0.000	0.997	0.003
M54.1 Radiculopathy	0.000	0.997	0.003
I85.0 Oesophageal varices with bleeding	0.000	0.997	0.003
M53 Other dorsopathies, not elsewhere classified	0.000	0.997	0.003
M54.0 Panniculitis affecting regions of neck and back	0.000	0.997	0.003
M54.9 Dorsalgia, unspecified	0.000	0.997	0.003
M51.37 Other intervertebral disc degeneration, lumbosacral region	0.000	0.997	0.003
M54.56 Low back pain (Lumbar region)	0.000	0.997	0.003
M54.2 Cervicalgia	0.000	0.997	0.003
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.000	0.997	0.003
E66 Obesity	0.000	0.997	0.003
M54.8 Other dorsalgia	0.000	0.997	0.003
K04.6 Periapical abscess with sinus	0.000	0.997	0.003
J34 Other disorders of nose and nasal sinuses	0.000	0.997	0.003
M51.19 Lumbar and other intervertebral disc disorders with radiculopathy; site unspecified	0.000	0.997	0.003
M51.16 Intervertebral disc disorders w radiculopathy, lumbar region	0.000	0.997	0.003
E66.8 Other obesity	0.000	0.997	0.003
K04.5 Chronic apical periodontitis	0.000	0.997	0.003
M54.64 Pain in thoracic spine (Thoracic region)	0.000	0.997	0.003
M54.30 Sciatica (Multiple sites in spine)	0.000	0.997	0.003
S42.00 Fracture of clavicle (closed)	0.003	0.997	0.000
M54.50 Low back pain (Multiple sites in spine)	0.000	0.997	0.003
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.003	0.997	0.000
M54.37 Sciatica (Lumbosacral region)	0.000	0.997	0.003
S42.20 Fracture of upper end of humerus (closed)	0.003	0.997	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.003	0.997	0.000
M54.35 Sciatica (Thoracolumbar region)	0.000	0.997	0.003
M54.34 Sciatica-Thoracic	0.000	0.997	0.003
M54.33 Sciatica-Cervicothoracic	0.000	0.997	0.003
M54.32 Sciatica-Cervical	0.000	0.997	0.003
M54.31 Sciatica-Occipit-atl-axl	0.000	0.997	0.003
M54.49 Lumbago with sciatica (Site unspecified)	0.000	0.997	0.003
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.003	0.997	0.000
S42.0 Fracture of clavicle	0.003	0.997	0.000
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.000	0.997	0.003
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.000	0.997	0.003
M54.44 Lumbago with sciatica-Thoracic	0.000	0.997	0.003
M54.43 Lumbago with sciatica-Cervicothoracic	0.000	0.997	0.003
M54.42 Lumbago with sciatica-Cervical	0.000	0.997	0.003
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.000	0.997	0.003
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.000	0.997	0.003
S42 Fracture of shoulder and upper arm	0.003	0.997	0.000
K04.4 Acute apical periodontitis of pulpal origin	0.000	0.997	0.003
M50.3 Other cervical disk degeneration	0.000	0.997	0.003
S42.2 Fracture of upper end of humerus	0.003	0.997	0.000
J34.3 Hypertrophy of nasal turbinates	0.000	0.997	0.003
Z90.7 Acquired absence of genital organ(s)	0.000	0.997	0.003
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.000	0.997	0.003
M54.12 Radiculopathy (Cervical region)	0.000	0.997	0.003
T43.2 Other and unspecified antidepressants	0.003	0.997	0.000
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.000	0.997	0.002
M54.69 Pain in thoracic spine-Site unspe	0.000	0.997	0.002
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.000	0.997	0.002
M54.67 Pain in thoracic spine-Lumbosacral	0.000	0.997	0.002
M54.66 Pain in thoracic spine-Lumbar	0.000	0.997	0.002
M54.62 Pain in thoracic spine-Cervical	0.000	0.997	0.002
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.000	0.997	0.002
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.000	0.997	0.002
S02.40 Fracture of malar and maxillary bones (closed)	0.000	0.997	0.003
Z87.4 Personal history of diseases of the genito-urinary system	0.000	0.997	0.003
M54.47 Lumbago with sciatica (Lumbosacral region)	0.000	0.997	0.002
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.000	0.997	0.002
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.000	0.997	0.002
M54.96 Dorsalgia, unspecified (Lumbar region)	0.000	0.997	0.003
K04.3 Abnormal hard tissue formation in pulp	0.000	0.997	0.003
K04.2 Pulp degeneration	0.000	0.997	0.003
K04.1 Necrosis of pulp	0.000	0.997	0.003
M54.19 Radiculopathy (Site unspecified)	0.000	0.997	0.002
M54.36 Sciatica (Lumbar region)	0.000	0.997	0.002
M54.55 Low back pain (Thoracolumbar region)	0.000	0.997	0.002
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.000	0.997	0.002
C50.2 Upper-inner quadrant of breast	0.000	0.997	0.003
M54.53 Low back pain-Cervicothoracic	0.000	0.997	0.002
M54.51 Low back pain-Occipit-atl-axl	0.000	0.997	0.002
M54.88 Other dorsalgia (Sacral and sacrococcygeal region)	0.000	0.997	0.002
M54.94 Dorsalgia, unspecified (Thoracic region)	0.000	0.997	0.002
D50.9 Iron deficiency anaemia, unspecified	0.000	0.997	0.002
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.997	0.002
K04.0 Pulpitis	0.000	0.997	0.002
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.003	0.997	0.000
M54.52 Low back pain-Cervical	0.000	0.997	0.002
M53.8 Other specified dorsopathies	0.000	0.997	0.002
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.000	0.997	0.002
M54.17 Radiculopathy (Lumbosacral region)	0.000	0.997	0.002
M54.54 Low back pain-Thoracic	0.000	0.997	0.002
M54.15 Radiculopathy (Thoracolumbar region)	0.000	0.997	0.002
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.000	0.997	0.002
M54.29 Cervicalgia-Site unspe	0.000	0.997	0.002
M54.13 Radiculopathy (Cervicothoracic region)	0.000	0.997	0.002
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.000	0.997	0.002
M53.9 Dorsopathy, unspecified	0.000	0.997	0.002
M54.10 Radiculopathy (Multiple sites in spine)	0.000	0.997	0.002

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations