TreeWAS – Variant ID: rs4889240

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
Z36.0 Antenatal screening for chromosomal anomalies	0.000	0.911	0.089
Z36 Antenatal screening	0.000	0.916	0.084
Z36.1 Antenatal screening for raised alphafetoprotein level	0.000	0.918	0.082
Z36.3 Antenatal screening for malformations using ultrasound and other physical methods	0.000	0.919	0.081
Z36.8 Other antenatal screening	0.000	0.930	0.070
E05.9 Thyrotoxicosis, unspecified	0.066	0.934	0.000
N73.6 Female pelvic peritoneal adhesions	0.063	0.937	0.000
Z36.2 Other antenatal screening based on amniocentesis	0.000	0.938	0.062
Z36.5 Antenatal screening for isoimmunisation	0.000	0.940	0.060
D63.0 Anaemia in neoplastic disease	0.050	0.950	0.000
Z36.4 Antenatal screening for foetal growth retardation using ultrasound and other physical methods	0.000	0.951	0.049
E05 Thyrotoxicosis [hyperthyroidism]	0.034	0.966	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.029	0.971	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.027	0.973	0.000
N73 Other female pelvic inflammatory diseases	0.026	0.974	0.000
E05.8 Other thyrotoxicosis	0.025	0.975	0.000
E05.5 Thyroid crisis or storm	0.024	0.975	0.000
E05.4 Thyrotoxicosis factitia	0.024	0.975	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.024	0.975	0.000
Z36.9 Antenatal screening, unspecified	0.000	0.976	0.023
N73.9 Female pelvic inflammatory disease, unspecified	0.022	0.978	0.000
N73.1 Chronic parametritis and pelvic cellulitis	0.021	0.979	0.000
N73.4 Female chronic pelvic peritonitis	0.019	0.981	0.000
N73.3 Female acute pelvic peritonitis	0.019	0.981	0.000
N73.2 Unspecified parametritis and pelvic cellulitis	0.019	0.981	0.000
Q21.1 Atrial septal defect	0.000	0.982	0.018
N73.5 Female pelvic peritonitis, unspecified	0.017	0.983	0.000
N73.0 Acute parametritis and pelvic cellulitis	0.016	0.984	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.016	0.984	0.000
N73.8 Other specified female pelvic inflammatory diseases	0.016	0.984	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.015	0.985	0.000
I49.0 Ventricular fibrillation and flutter	0.013	0.987	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.012	0.988	0.000
Q21 Congenital malformations of cardiac septa	0.000	0.988	0.012
N48.6 Balanitis xerotica obliterans	0.000	0.989	0.011
Z98.1 Arthrodesis status	0.011	0.989	0.000
C16.0 Cardia	0.011	0.989	0.000
J15.4 Pneumonia due to other streptococci	0.000	0.990	0.010
Q21.9 Congenital malformation of cardiac septum, unspecified	0.000	0.990	0.010
Q21.3 Tetralogy of Fallot	0.000	0.990	0.009
Q21.8 Other congenital malformations of cardiac septa	0.000	0.991	0.009
Q21.0 Ventricular septal defect	0.000	0.991	0.009
N48.1 Balanoposthitis	0.000	0.991	0.009
Q21.4 Aortopulmonary septal defect	0.000	0.991	0.009
Q21.2 Atrioventricular septal defect	0.000	0.991	0.009
N48.5 Ulcer of penis	0.000	0.991	0.008
N48 Other disorders of penis	0.000	0.992	0.008
K57.1 Diverticular disease of small intestine without perforation or abscess	0.007	0.993	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.006	0.994	0.000
E00-E07 Disorders of thyroid gland	0.006	0.994	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.006	0.994	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.006	0.994	0.000
J84.1 Other interstitial pulmonary diseases with fibrosis	0.006	0.994	0.000
N48.9 Disorder of penis, unspecified	0.000	0.994	0.006
J43.9 Emphysema, unspecified	0.000	0.994	0.006
D32.0 Cerebral meninges	0.000	0.994	0.006
H83.0 Labyrinthitis	0.000	0.995	0.005
N48.8 Other specified disorders of penis	0.000	0.995	0.005
D60-D64 Aplastic and other anaemias	0.005	0.995	0.000
C16 Malignant neoplasm of stomach	0.005	0.995	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.005	0.995	0.000
E07 Other disorders of thyroid	0.005	0.995	0.000
N48.2 Other inflammatory disorders of penis	0.000	0.995	0.005
M81.98 Osteoporosis, unspecified (Other)	0.005	0.995	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.005	0.995	0.000
E00 Congenital iodine-deficiency syndrome	0.005	0.995	0.000
Z39.0 Care and examination immediately after delivery	0.000	0.995	0.005
H91.9 Hearing loss, unspecified	0.005	0.995	0.000
C16.9 Stomach, unspecified	0.005	0.995	0.000
N48.3 Priapism	0.000	0.995	0.004
L71.9 Rosacea, unspecified	0.005	0.995	0.000
E07.8 Other specified disorders of thyroid	0.004	0.995	0.000
M84.06 Malunion of fracture (Lower leg)	0.004	0.996	0.000
J15.1 Pneumonia due to Pseudomonas	0.000	0.996	0.004
K76.0 Fatty (change of) liver, not elsewhere classified	0.004	0.996	0.000
F01.9 Vascular dementia, unspecified	0.004	0.996	0.000
D61 Other aplastic anaemias	0.004	0.996	0.000
C16.3 Pyloric antrum	0.004	0.996	0.000
N48.0 Leukoplakia of penis	0.000	0.996	0.004
M84.0 Malunion of fracture	0.004	0.996	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.004	0.996	0.000
C16.2 Body of stomach	0.004	0.996	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.004	0.996	0.000
E04 Other non-toxic goitre	0.004	0.996	0.000
S52.10 Fracture of upper end of radius (closed)	0.000	0.996	0.004
D64.8 Other specified anaemias	0.004	0.996	0.000
C16.4 Pylorus	0.004	0.996	0.000
D64 Other anaemias	0.004	0.996	0.000
G60.0 Hereditary motor and sensory neuropathy	0.004	0.996	0.000
M81.9 Osteoporosis, unspecified	0.004	0.996	0.000
Y95 Nosocomial condition	0.000	0.996	0.004
M85.65 Other cyst of bone (Pelvic region and thigh)	0.004	0.996	0.000
M84.05 Malunion of fracture (Pelvic region and thigh)	0.004	0.996	0.000
E07.1 Dyshormogenetic goitre	0.004	0.996	0.000
E07.0 Hypersecretion of calcitonin	0.004	0.996	0.000
M84.04 Malunion of fracture (Hand)	0.004	0.996	0.000
J15 Bacterial pneumonia, not elsewhere classified	0.000	0.996	0.004
E06 Thyroiditis	0.004	0.996	0.000
E06.9 Thyroiditis, unspecified	0.004	0.996	0.000
C16.6 Greater curvature of stomach, unspecified	0.004	0.996	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.003	0.996	0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.003	0.996	0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.003	0.996	0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.003	0.996	0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.003	0.996	0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.003	0.996	0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.003	0.996	0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.003	0.996	0.000
E04.9 Non-toxic goitre, unspecified	0.004	0.996	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.004	0.996	0.000
C16.8 Overlapping lesion of stomach	0.003	0.996	0.000
M84.02 Malunion of fracture (Upper arm)	0.004	0.996	0.000
D61.1 Drug-induced aplastic anaemia	0.003	0.996	0.000
C16.5 Lesser curvature of stomach, unspecified	0.003	0.996	0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters	0.004	0.996	0.000
D61.0 Constitutional aplastic anaemia	0.003	0.996	0.000
J15.8 Other bacterial pneumonia	0.000	0.996	0.003
K74.3 Primary biliary cirrhosis	0.000	0.997	0.003
R22.1 Localised swelling, mass and lump, neck	0.003	0.997	0.000
N85.1 Endometrial adenomatous hyperplasia	0.000	0.997	0.003
D61.8 Other specified aplastic anaemias	0.003	0.997	0.000
D61.3 Idiopathic aplastic anaemia	0.003	0.997	0.000
D61.2 Aplastic anaemia due to other external agents	0.003	0.997	0.000
D61.9 Aplastic anaemia, unspecified	0.003	0.997	0.000
E04.0 Non-toxic diffuse goitre	0.003	0.997	0.000
M84.01 Malunion of fracture (Shoulder region)	0.003	0.997	0.000
M85.6 Other cyst of bone	0.003	0.997	0.000
M81.92 Osteoporosis, unspecified (Upper arm)	0.003	0.997	0.000
K74.0 Hepatic fibrosis	0.000	0.997	0.003
M81 Osteoporosis without pathological fracture	0.003	0.997	0.000
M84.09 Malunion of fracture (Site unspecified)	0.003	0.997	0.000
M84.00 Malunion of fracture (Multiple sites)	0.003	0.997	0.000
I70.00 Atherosclerosis of aorta (without gangrene)	0.003	0.997	0.000
D60.9 Acquired pure red cell aplasia, unspecified	0.003	0.997	0.000
D64.0 Hereditary sideroblastic anaemia	0.003	0.997	0.000
D60.8 Other acquired pure red cell aplasias	0.003	0.997	0.000
D60.1 Transient acquired pure red cell aplasia	0.003	0.997	0.000
D60.0 Chronic acquired pure red cell aplasia	0.003	0.997	0.000
R22.2 Localised swelling, mass and lump, trunk	0.000	0.997	0.003
G60.8 Other hereditary and idiopathic neuropathies	0.003	0.997	0.000
D64.3 Other sideroblastic anaemias	0.003	0.997	0.000
H06.2 Dysthyroid exophthalmos	0.003	0.997	0.000
E04.8 Other specified non-toxic goitre	0.003	0.997	0.000
D64.4 Congenital dyserythropoietic anaemia	0.003	0.997	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.003	0.997	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.003	0.997	0.000
M85 Other disorders of bone density and structure	0.003	0.997	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.003	0.997	0.000
M85.68 Other cyst of bone (Other)	0.003	0.997	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.000	0.997	0.003
J15.3 Pneumonia due to streptococcus, group B	0.000	0.997	0.003
J15.5 Pneumonia due to Escherichia coli	0.000	0.997	0.003
F01 Vascular dementia	0.003	0.997	0.000
G60 Hereditary and idiopathic neuropathy	0.003	0.997	0.000
M84.08 Malunion of fracture (Other)	0.003	0.997	0.000
E06.4 Drug-induced thyroiditis	0.003	0.997	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.003	0.997	0.000
E06.0 Acute thyroiditis	0.003	0.997	0.000
K74 Fibrosis and cirrhosis of liver	0.000	0.997	0.003
M81.94 Osteoporosis, unspecified (Hand)	0.003	0.997	0.000
C16.1 Fundus of stomach	0.003	0.997	0.000
E07.9 Disorder of thyroid, unspecified	0.003	0.997	0.000
K74.5 Biliary cirrhosis, unspecified	0.000	0.997	0.003
M81.93 Osteoporosis, unspecified (Forearm)	0.003	0.997	0.000
M81.4 Drug-induced osteoporosis	0.003	0.997	0.000
M06.34 Rheumatoid nodule (Hand)	0.003	0.997	0.000
M06.3 Rheumatoid nodule	0.003	0.997	0.000
M84 Disorders of continuity of bone	0.003	0.997	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.003	0.997	0.000
M96.0 Pseudarthrosis after fusion or arthrodesis	0.003	0.997	0.000
M81.91 Osteoporosis, unspecified (Shoulder region)	0.003	0.997	0.000
M54.49 Lumbago with sciatica (Site unspecified)	0.003	0.997	0.000
M85.4 Solitary bone cyst	0.003	0.997	0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.003	0.997	0.000
M85.46 Solitary bone cyst (Lower leg)	0.003	0.997	0.000
M81.2 Osteoporosis of disuse	0.003	0.997	0.000
M85.69 Other cyst of bone (Site unspecified)	0.003	0.997	0.000
M85.63 Other cyst of bone (Forearm)	0.003	0.997	0.000
M85.62 Other cyst of bone (Upper arm)	0.003	0.997	0.000
M85.61 Other cyst of bone (Shoulder region)	0.003	0.997	0.000
M85.60 Other cyst of bone (Multiple sites)	0.003	0.997	0.000
H16.0 Corneal ulcer	0.003	0.997	0.000
M81.8 Other osteoporosis	0.003	0.997	0.000
M81.96 Osteoporosis, unspecified (Lower leg)	0.003	0.997	0.000
J15.9 Bacterial pneumonia, unspecified	0.000	0.997	0.002
M81.40 Drug-induced osteoporosis (Multiple sites)	0.003	0.997	0.000
M81.6 Localised osteoporosis [Lequesne]	0.003	0.997	0.000
M81.5 Idiopathic osteoporosis	0.003	0.997	0.000
M81.1 Postoophorectomy osteoporosis	0.003	0.997	0.000
E06.1 Subacute thyroiditis	0.002	0.997	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.002	0.997	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.003	0.997	0.000
K25.3 Acute without haemorrhage or perforation	0.003	0.997	0.000
M96.1 Postlaminectomy syndrome, not elsewhere classified	0.003	0.997	0.000
Z39 Postpartum care and examination	0.000	0.997	0.003
M80-M85 Disorders of bone density and structure	0.003	0.997	0.000
M85.9 Disorder of bone density and structure, unspecified	0.002	0.997	0.000
G60.9 Hereditary and idiopathic neuropathy, unspecified	0.002	0.997	0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.003	0.997	0.000
J15.0 Pneumonia due to Klebsiella pneumoniae	0.000	0.997	0.002
M84.8 Other disorders of continuity of bone	0.002	0.997	0.000
M06.30 Rheumatoid nodule (Multiple sites)	0.002	0.997	0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.000	0.997	0.003
M85.66 Other cyst of bone (Lower leg)	0.002	0.997	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.002	0.997	0.000
M84.03 Malunion of fracture (Forearm)	0.002	0.997	0.000
F03 Unspecified dementia	0.003	0.997	0.000
J15.6 Pneumonia due to other aerobic Gram-negative bacteria	0.000	0.997	0.002
M85.2 Hyperostosis of skull	0.002	0.997	0.000
D62 Acute posthaemorrhagic anaemia	0.002	0.997	0.000
E06.5 Other chronic thyroiditis	0.002	0.998	0.000
E03 Other hypothyroidism	0.002	0.998	0.000
M85.5 Aneurysmal bone cyst	0.002	0.998	0.000
M85.3 Osteitis condensans	0.002	0.998	0.000
M85.1 Skeletal fluorosis	0.002	0.998	0.000
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.002	0.998	0.000
M81.0 Postmenopausal osteoporosis	0.002	0.998	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.002	0.998	0.000
F01.8 Other vascular dementia	0.002	0.998	0.000
F01.3 Mixed cortical and subcortical vascular dementia	0.002	0.998	0.000
F01.2 Subcortical vascular dementia	0.002	0.998	0.000
F01.0 Vascular dementia of acute onset	0.002	0.998	0.000
G60.3 Idiopathic progressive neuropathy	0.002	0.998	0.000
G60.2 Neuropathy in association with hereditary ataxia	0.002	0.998	0.000
G60.1 Refsum's disease	0.002	0.998	0.000
S86.8 Injury of other muscles and tendons at lower leg level	0.000	0.998	0.002
K74.4 Secondary biliary cirrhosis	0.000	0.998	0.002
K74.2 Hepatic fibrosis with hepatic sclerosis	0.000	0.998	0.002
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.000	0.998	0.002
M85.8 Other specified disorders of bone density and structure	0.002	0.998	0.000
M81.48 Drug-induced osteoporosis (Other)	0.002	0.998	0.000
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.002	0.998	0.000
M81.46 Drug-induced osteoporosis (Lower leg)	0.002	0.998	0.000
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.002	0.998	0.000
M81.44 Drug-induced osteoporosis (Hand)	0.002	0.998	0.000
M81.43 Drug-induced osteoporosis (Forearm)	0.002	0.998	0.000
M81.42 Drug-induced osteoporosis (Upper arm)	0.002	0.998	0.000
M81.41 Drug-induced osteoporosis (Shoulder region)	0.002	0.998	0.000
S62.61 Fracture of other finger (open)	0.002	0.998	0.000
L08.8 Other specified local infections of skin and subcutaneous tissue	0.002	0.998	0.000
M96.8 Other postprocedural musculoskeletal disorders	0.002	0.998	0.000
S86 Injury of muscle and tendon at lower leg level	0.000	0.998	0.002
M96.9 Postprocedural musculoskeletal disorder, unspecified	0.002	0.998	0.000
H91 Other hearing loss	0.002	0.998	0.000
M84.3 Stress fracture, not elsewhere classified	0.002	0.998	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.002	0.998	0.000
M06.38 Rheumatoid nodule (Other)	0.002	0.998	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.002	0.998	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.002	0.998	0.000
M06.33 Rheumatoid nodule (Forearm)	0.002	0.998	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.002	0.998	0.000
M81.49 Drug-induced osteoporosis (Site unspecified)	0.002	0.998	0.000
F01.1 Multi-infarct dementia	0.002	0.998	0.000
H91.2 Sudden idiopathic hearing loss	0.002	0.998	0.000
M84.9 Disorder of continuity of bone, unspecified	0.002	0.998	0.000
M85.47 Solitary bone cyst (Ankle and foot)	0.002	0.998	0.000
E04.1 Non-toxic single thyroid nodule	0.002	0.998	0.000
K74.1 Hepatic sclerosis	0.000	0.998	0.002
R93.5 Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum	0.002	0.998	0.000
M81.20 Osteoporosis of disuse (Multiple sites)	0.002	0.998	0.000
M85.0 Fibrous dysplasia (monostotic)	0.002	0.998	0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.002	0.998	0.000
Y91 Evidence of alcohol involvement determined by level of intoxication	0.000	0.998	0.002
M85.49 Solitary bone cyst (Site unspecified)	0.002	0.998	0.000
M85.48 Solitary bone cyst (Other)	0.002	0.998	0.000
M85.44 Solitary bone cyst (Hand)	0.002	0.998	0.000
M85.43 Solitary bone cyst (Forearm)	0.002	0.998	0.000
M85.42 Solitary bone cyst (Upper arm)	0.002	0.998	0.000
M85.41 Solitary bone cyst (Shoulder region)	0.002	0.998	0.000
M85.40 Solitary bone cyst (Multiple sites)	0.002	0.998	0.000
L98.4 Chronic ulcer of skin, not elsewhere classified	0.000	0.998	0.002
N82.4 Other female intestinal-genital tract fistulae	0.002	0.998	0.000
Y88.3 Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient or of later complication, without mention of misadventure at the time of the procedure	0.000	0.998	0.002
M81.80 Other osteoporosis (Multiple sites)	0.002	0.998	0.000
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.002	0.998	0.000
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.002	0.998	0.000
F02.8 Dementia in other specified diseases classified elsewhere	0.002	0.998	0.000
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.000	0.998	0.002
F02 Dementia in other diseases classified elsewhere	0.002	0.998	0.000
M81.29 Osteoporosis of disuse (Site unspecified)	0.002	0.998	0.000
M81.28 Osteoporosis of disuse (Other)	0.002	0.998	0.000
M81.27 Osteoporosis of disuse (Ankle and foot)	0.002	0.998	0.000
M81.26 Osteoporosis of disuse (Lower leg)	0.002	0.998	0.000
M81.25 Osteoporosis of disuse (Pelvic region and thigh)	0.002	0.998	0.000
M81.24 Osteoporosis of disuse (Hand)	0.002	0.998	0.000
M81.23 Osteoporosis of disuse (Forearm)	0.002	0.998	0.000
M81.22 Osteoporosis of disuse (Upper arm)	0.002	0.998	0.000
M81.21 Osteoporosis of disuse (Shoulder region)	0.002	0.998	0.000
M06.0 Seronegative rheumatoid arthritis	0.002	0.998	0.000
M81.89 Other osteoporosis (Site unspecified)	0.002	0.998	0.000
M81.88 Other osteoporosis (Other)	0.002	0.998	0.000
M81.87 Other osteoporosis (Ankle and foot)	0.002	0.998	0.000
M81.86 Other osteoporosis (Lower leg)	0.002	0.998	0.000
M81.85 Other osteoporosis (Pelvic region and thigh)	0.002	0.998	0.000
M81.84 Other osteoporosis (Hand)	0.002	0.998	0.000
M81.83 Other osteoporosis (Forearm)	0.002	0.998	0.000
M81.82 Other osteoporosis (Upper arm)	0.002	0.998	0.000
M81.81 Other osteoporosis (Shoulder region)	0.002	0.998	0.000
Y91.9 Alcohol involvement, not otherwise specified	0.000	0.998	0.002
S02.00 Fracture of vault of skull (closed)	0.000	0.998	0.002
K74.6 Other and unspecified cirrhosis of liver	0.000	0.998	0.002
M81.19 Postoophorectomy osteoporosis (Site unspecified)	0.002	0.998	0.000
M81.18 Postoophorectomy osteoporosis (Other)	0.002	0.998	0.000
M81.17 Postoophorectomy osteoporosis (Ankle and foot)	0.002	0.998	0.000
M81.16 Postoophorectomy osteoporosis (Lower leg)	0.002	0.998	0.000
M81.15 Postoophorectomy osteoporosis (Pelvic region and thigh)	0.002	0.998	0.000
M81.14 Postoophorectomy osteoporosis (Hand)	0.002	0.998	0.000
M81.13 Postoophorectomy osteoporosis (Forearm)	0.002	0.998	0.000
M81.12 Postoophorectomy osteoporosis (Upper arm)	0.002	0.998	0.000
M81.11 Postoophorectomy osteoporosis (Shoulder region)	0.002	0.998	0.000
M81.10 Postoophorectomy osteoporosis (Multiple sites)	0.002	0.998	0.000
M81.59 Idiopathic osteoporosis (Site unspecified)	0.002	0.998	0.000
M81.58 Idiopathic osteoporosis (Other)	0.002	0.998	0.000
M81.57 Idiopathic osteoporosis (Ankle and foot)	0.002	0.998	0.000
M81.56 Idiopathic osteoporosis (Lower leg)	0.002	0.998	0.000
M81.55 Idiopathic osteoporosis (Pelvic region and thigh)	0.002	0.998	0.000
M81.54 Idiopathic osteoporosis (Hand)	0.002	0.998	0.000
M81.53 Idiopathic osteoporosis (Forearm)	0.002	0.998	0.000
M81.52 Idiopathic osteoporosis (Upper arm)	0.002	0.998	0.000
M81.51 Idiopathic osteoporosis (Shoulder region)	0.002	0.998	0.000
M81.50 Idiopathic osteoporosis (Multiple sites)	0.002	0.998	0.000
M81.69 Localized osteoporosis [Lequesne] (Site unspecified)	0.002	0.998	0.000
M81.68 Localized osteoporosis [Lequesne] (Other)	0.002	0.998	0.000
M81.67 Localized osteoporosis [Lequesne] (Ankle and foot)	0.002	0.998	0.000
M81.66 Localized osteoporosis [Lequesne] (Lower leg)	0.002	0.998	0.000
M81.65 Localized osteoporosis [Lequesne] (Pelvic region and thigh)	0.002	0.998	0.000
M81.64 Localized osteoporosis [Lequesne] (Hand)	0.002	0.998	0.000
M81.63 Localized osteoporosis [Lequesne] (Forearm)	0.002	0.998	0.000
M81.62 Localized osteoporosis [Lequesne] (Upper arm)	0.002	0.998	0.000
M81.61 Localized osteoporosis [Lequesne] (Shoulder region)	0.002	0.998	0.000
M81.60 Localized osteoporosis [Lequesne] (Multiple sites)	0.002	0.998	0.000
H91.8 Other specified hearing loss	0.002	0.998	0.000
N48.4 Impotence of organic origin	0.000	0.998	0.002
F02.0 Dementia in Pick's disease	0.002	0.998	0.000
H26.1 Traumatic cataract	0.000	0.998	0.002
M81.39 Postsurgical malabsorption osteoporosis (Site unspecified)	0.002	0.998	0.000
M81.38 Postsurgical malabsorption osteoporosis (Other)	0.002	0.998	0.000
M81.37 Postsurgical malabsorption osteoporosis (Ankle and foot)	0.002	0.998	0.000
M81.36 Postsurgical malabsorption osteoporosis (Lower leg)	0.002	0.998	0.000
M81.35 Postsurgical malabsorption osteoporosis (Pelvic region and thigh)	0.002	0.998	0.000
M81.34 Postsurgical malabsorption osteoporosis (Hand)	0.002	0.998	0.000
M81.33 Postsurgical malabsorption osteoporosis (Forearm)	0.002	0.998	0.000
M81.32 Postsurgical malabsorption osteoporosis (Upper arm)	0.002	0.998	0.000
M81.31 Postsurgical malabsorption osteoporosis (Shoulder region)	0.002	0.998	0.000
M96.6 Fracture of bone following insertion of orthopaedic implant, joint prosthesis or bone plate	0.002	0.998	0.000
M96.5 Postradiation scoliosis	0.002	0.998	0.000
M96.4 Postsurgical lordosis	0.002	0.998	0.000
M96.3 Postlaminectomy kyphosis	0.002	0.998	0.000
M96.2 Postradiation kyphosis	0.002	0.998	0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level	0.000	0.998	0.002
M85.64 Other cyst of bone (Hand)	0.002	0.998	0.000
M85.98 Disorder of bone density and structure, unspecified (Other)	0.002	0.998	0.000
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.002	0.998	0.000
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.002	0.998	0.000
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.002	0.998	0.000
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.002	0.998	0.000
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.002	0.998	0.000
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.002	0.998	0.000
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.002	0.998	0.000
M83 Adult osteomalacia	0.002	0.998	0.000
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.002	0.998	0.000
M81.30 Postsurgical malabsorption osteoporosis (Multiple sites)	0.002	0.998	0.000
M84.89 Other disorders of continuity of bone (Site unspecified)	0.002	0.998	0.000
M84.88 Other disorders of continuity of bone (Other)	0.002	0.998	0.000
M84.86 Other disorders of continuity of bone (Lower leg)	0.002	0.998	0.000
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.002	0.998	0.000
M84.84 Other disorders of continuity of bone (Hand)	0.002	0.998	0.000
M84.82 Other disorders of continuity of bone (Upper arm)	0.002	0.998	0.000
M84.81 Other disorders of continuity of bone (Shoulder region)	0.002	0.998	0.000
M84.80 Other disorders of continuity of bone (Multiple sites)	0.002	0.998	0.000
M85.20 Hyperostosis of skull-Mult sites	0.002	0.998	0.000
H50.9 Strabismus, unspecified	0.002	0.998	0.000
Z39.2 Routine postpartum follow-up	0.000	0.998	0.002
M84.2 Delayed union of fracture	0.002	0.998	0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.000	0.998	0.002
M85.29 Hyperostosis of skull-Site unspec	0.002	0.998	0.000
M85.28 Hyperostosis of skull-Other	0.002	0.998	0.000
M85.27 Hyperostosis of skull-Ankle/Foot	0.002	0.998	0.000
M85.26 Hyperostosis of skull-Lower Leg	0.002	0.998	0.000
M85.25 Hyperostosis of skull-Pelvic/Thigh	0.002	0.998	0.000
M85.24 Hyperostosis of skull-Hand	0.002	0.998	0.000
M85.23 Hyperostosis of skull-Forearm	0.002	0.998	0.000
M85.22 Hyperostosis of skull-Upper arm	0.002	0.998	0.000
M85.21 Hyperostosis of skull-Shldr region	0.002	0.998	0.000
E03.5 Myxoedema coma	0.002	0.998	0.000
E03.4 Atrophy of thyroid (acquired)	0.002	0.998	0.000
E03.3 Postinfectious hypothyroidism	0.002	0.998	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.002	0.998	0.000
J43 Emphysema	0.000	0.998	0.002
M85.19 Skeletal fluorosis (Site unspecified)	0.002	0.998	0.000
M85.18 Skeletal fluorosis (Other)	0.002	0.998	0.000
M85.17 Skeletal fluorosis (Ankle and foot)	0.002	0.998	0.000
M85.16 Skeletal fluorosis (Lower leg)	0.002	0.998	0.000
M85.15 Skeletal fluorosis (Pelvic region and thigh)	0.002	0.998	0.000
M85.14 Skeletal fluorosis (Hand)	0.002	0.998	0.000
M85.13 Skeletal fluorosis (Forearm)	0.002	0.998	0.000
M85.12 Skeletal fluorosis (Upper arm)	0.002	0.998	0.000
M85.11 Skeletal fluorosis (Shoulder region)	0.002	0.998	0.000
M85.10 Skeletal fluorosis (Multiple sites)	0.002	0.998	0.000
M85.39 Osteitis condensans (Site unspecified)	0.002	0.998	0.000
M85.38 Osteitis condensans (Other)	0.002	0.998	0.000
M85.37 Osteitis condensans (Ankle and foot)	0.002	0.998	0.000
M85.36 Osteitis condensans (Lower leg)	0.002	0.998	0.000
M85.35 Osteitis condensans (Pelvic region and thigh)	0.002	0.998	0.000
M85.34 Osteitis condensans (Hand)	0.002	0.998	0.000
M85.33 Osteitis condensans (Forearm)	0.002	0.998	0.000
M85.32 Osteitis condensans (Upper arm)	0.002	0.998	0.000
M85.31 Osteitis condensans (Shoulder region)	0.002	0.998	0.000
M85.30 Osteitis condensans (Multiple sites)	0.002	0.998	0.000
M85.59 Aneurysmal bone cyst (Site unspecified)	0.002	0.998	0.000
M85.58 Aneurysmal bone cyst (Other)	0.002	0.998	0.000
M85.57 Aneurysmal bone cyst (Ankle and foot)	0.002	0.998	0.000
M85.56 Aneurysmal bone cyst (Lower leg)	0.002	0.998	0.000
M85.55 Aneurysmal bone cyst (Pelvic region and thigh)	0.002	0.998	0.000
M85.54 Aneurysmal bone cyst (Hand)	0.002	0.998	0.000
M85.53 Aneurysmal bone cyst (Forearm)	0.002	0.998	0.000
M85.52 Aneurysmal bone cyst (Upper arm)	0.002	0.998	0.000
M85.51 Aneurysmal bone cyst (Shoulder region)	0.002	0.998	0.000
M85.50 Aneurysmal bone cyst (Multiple sites)	0.002	0.998	0.000
M81.08 Postmenopausal osteoporosis (Other)	0.002	0.998	0.000
M81.07 Postmenopausal osteoporosis (Ankle and foot)	0.002	0.998	0.000
M81.06 Postmenopausal osteoporosis (Lower leg)	0.002	0.998	0.000
M81.05 Postmenopausal osteoporosis (Pelvic region and thigh)	0.002	0.998	0.000
M81.04 Postmenopausal osteoporosis (Hand)	0.002	0.998	0.000
M81.03 Postmenopausal osteoporosis (Forearm)	0.002	0.998	0.000
M81.02 Postmenopausal osteoporosis (Upper arm)	0.002	0.998	0.000
M81.01 Postmenopausal osteoporosis (Shoulder region)	0.002	0.998	0.000
M81.00 Postmenopausal osteoporosis (Multiple sites)	0.002	0.998	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.002	0.998	0.000
E03.1 Congenital hypothyroidism without goitre	0.002	0.998	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.002	0.998	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.002	0.998	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.002	0.998	0.000
J15.2 Pneumonia due to staphylococcus	0.000	0.998	0.002
N42.2 Atrophy of prostate	0.000	0.998	0.002
J84 Other interstitial pulmonary diseases	0.002	0.998	0.000
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.002	0.998	0.000
M82 Osteoporosis in diseases classified elsewhere	0.002	0.998	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.002	0.998	0.000
Y98 Lifestyle-related condition	0.000	0.998	0.002
Y97 Environmental-pollution-related condition	0.000	0.998	0.002
Y96 Work-related condition	0.000	0.998	0.002
M84.83 Other disorders of continuity of bone (Forearm)	0.002	0.998	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.002	0.998	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.002	0.998	0.000
S52.1 Fracture of upper end of radius	0.000	0.998	0.002
S86.0 Injury of Achilles tendon	0.000	0.998	0.002
S86.7 Injury of multiple muscles and tendons at lower leg level	0.000	0.998	0.002
Y90.6 Blood alcohol level of 120-199 mg/100 ml	0.000	0.998	0.002
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.002	0.998	0.000
H91.0 Ototoxic hearing loss	0.002	0.998	0.000
M84.39 Stress fracture, not elsewhere classified (Site unspecified)	0.002	0.998	0.000
M84.38 Stress fracture, not elsewhere classified (Other)	0.002	0.998	0.000
M84.36 Stress fracture, not elsewhere classified (Lower leg)	0.002	0.998	0.000
M84.35 Stress fracture, not elsewhere classified (Pelvic region and thigh)	0.002	0.998	0.000
M84.34 Stress fracture, not elsewhere classified (Hand)	0.002	0.998	0.000
M84.33 Stress fracture, not elsewhere classified (Forearm)	0.002	0.998	0.000
M84.32 Stress fracture, not elsewhere classified (Upper arm)	0.002	0.998	0.000
M84.31 Stress fracture, not elsewhere classified (Shoulder region)	0.002	0.998	0.000
M84.30 Stress fracture, not elsewhere classified (Multiple sites)	0.002	0.998	0.000
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.002	0.998	0.000
M84.99 Disorder of continuity of bone, unspecified (Site unspecified)	0.002	0.998	0.000
M84.98 Disorder of continuity of bone, unspecified (Other)	0.002	0.998	0.000
M84.97 Disorder of continuity of bone, unspecified (Ankle and foot)	0.002	0.998	0.000
M84.96 Disorder of continuity of bone, unspecified (Lower leg)	0.002	0.998	0.000
M84.95 Disorder of continuity of bone, unspecified (Pelvic region and thigh)	0.002	0.998	0.000
M84.94 Disorder of continuity of bone, unspecified (Hand)	0.002	0.998	0.000
M84.93 Disorder of continuity of bone, unspecified (Forearm)	0.002	0.998	0.000
M84.92 Disorder of continuity of bone, unspecified (Upper arm)	0.002	0.998	0.000
M84.91 Disorder of continuity of bone, unspecified (Shoulder region)	0.002	0.998	0.000
M84.90 Disorder of continuity of bone, unspecified (Multiple sites)	0.002	0.998	0.000
H91.3 Deaf mutism, not elsewhere classified	0.002	0.998	0.000
L71 Rosacea	0.002	0.998	0.000
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.002	0.998	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.002	0.998	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.002	0.998	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.002	0.998	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.002	0.998	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.002	0.998	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.002	0.998	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.002	0.998	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.002	0.998	0.000
E03.8 Other specified hypothyroidism	0.002	0.998	0.000
M33.2 Polymyositis	0.002	0.998	0.000
M84.4 Pathological fracture, not elsewhere classified	0.002	0.998	0.000
R68.0 Hypothermia, not associated with low environmental temperature	0.000	0.998	0.002
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.002	0.998	0.000
J43.8 Other emphysema	0.000	0.998	0.002
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system	0.002	0.998	0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.000	0.998	0.002
Y91.3 Very severe alcohol intoxication	0.000	0.998	0.002
Y91.2 Severe alcohol intoxication	0.000	0.998	0.002
Y91.1 Moderate alcohol intoxication	0.000	0.998	0.002
Y91.0 Mild alcohol intoxication	0.000	0.998	0.002
M86.97 Osteomyelitis, unspecified (Ankle and foot)	0.002	0.998	0.000
F02.4 Dementia in human immunodeficiency virus [HIV] disease	0.002	0.998	0.000
F02.2 Dementia in Huntington's disease	0.002	0.998	0.000
F02.1 Dementia in Creutzfeldt-Jakob disease	0.002	0.998	0.000
M83.1 Senile osteomalacia	0.002	0.998	0.000
M06.08 Seronegative rheumatoid arthritis (Other)	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations