TreeWAS – Variant ID: rs5007258

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.000	1.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.000	1.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.000	1.000
E05.0 Thyrotoxicosis with diffuse goitre	1.000	0.000	0.000
K90.0 Coeliac disease	1.000	0.000	0.000
L40.9 Psoriasis, unspecified	0.000	0.000	1.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.000	0.000	1.000
M06.9 Rheumatoid arthritis, unspecified	0.000	0.000	1.000
G35 Multiple sclerosis	1.000	0.000	0.000
M06 Other rheumatoid arthritis	0.000	0.000	1.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.000	1.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	1.000	0.000	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.000	1.000
D86 Sarcoidosis	1.000	0.000	0.000
E05.9 Thyrotoxicosis, unspecified	1.000	0.000	0.000
D80-D89 Certain disorders involving the immune mechanism	1.000	0.000	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	1.000	0.000	0.000
M05 Seropositive rheumatoid arthritis	0.000	0.000	1.000
M05-M14 Inflammatory polyarthropathies	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	1.000	0.000	0.000
M06.3 Rheumatoid nodule	0.000	0.000	1.000
D69 Purpura and other haemorrhagic conditions	0.999	0.001	0.000
L40 Psoriasis	0.000	0.002	0.998
C82.9 Follicular non-Hodgkin's lymphoma, unspecified	0.000	0.002	0.998
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.002	0.998
D86.0 Sarcoidosis of lung	0.998	0.002	0.000
D69.6 Thrombocytopenia, unspecified	0.997	0.003	0.000
D86.9 Sarcoidosis, unspecified	0.997	0.003	0.000
L40.5 Arthropathic psoriasis	0.000	0.003	0.997
M06.0 Seronegative rheumatoid arthritis	0.000	0.005	0.995
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.005	0.995
M06.34 Rheumatoid nodule (Hand)	0.000	0.006	0.994
D50-D53 Nutritional anaemias	0.993	0.007	0.000
R31 Unspecified haematuria	0.000	0.008	0.992
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.012	0.988
C82 Follicular [nodular] non-Hodgkin's lymphoma	0.000	0.021	0.979
K90 Intestinal malabsorption	0.974	0.026	0.000
D52 Folate deficiency anaemia	0.968	0.032	0.000
D68 Other coagulation defects	0.964	0.036	0.000
D51 Vitamin B12 deficiency anaemia	0.963	0.037	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.037	0.963
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.000	0.037	0.963
D52.9 Folate deficiency anaemia, unspecified	0.951	0.049	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.000	0.049	0.951
M07 Psoriatic and enteropathic arthropathies	0.000	0.056	0.944
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.057	0.943
M06.32 Rheumatoid nodule (Upper arm)	0.000	0.059	0.941
D69.3 Idiopathic thrombocytopenic purpura	0.935	0.065	0.000
E27.1 Primary adrenocortical insufficiency	0.928	0.072	0.000
C82.0 Small cleaved cell, follicular	0.000	0.076	0.924
K90.9 Intestinal malabsorption, unspecified	0.920	0.080	0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.919	0.081	0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.912	0.088	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.092	0.908
M07.3 Other psoriatic arthropathies	0.000	0.093	0.907
M06.37 Rheumatoid nodule (Ankle and foot)	0.000	0.093	0.907
L40.0 Psoriasis vulgaris	0.000	0.097	0.903
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.903	0.097	0.000
D68.5 Primary Thrombophilia	0.903	0.097	0.000
C82.7 Other types of follicular non-Hodgkin's lymphoma	0.000	0.099	0.901
M06.98 Rheumatoid arthritis, unspecified (Other)	0.000	0.107	0.893
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.000	0.110	0.890
D69.4 Other primary thrombocytopenia	0.887	0.113	0.000
M14 Arthropathies in other diseases classified elsewhere	0.000	0.118	0.882
M07.39 Other psoriatic arthropathies (Site unspecified)	0.000	0.127	0.873
E27 Other disorders of adrenal gland	0.856	0.144	0.000
M06.4 Inflammatory polyarthropathy	0.000	0.144	0.856
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.851	0.149	0.000
K90.8 Other intestinal malabsorption	0.847	0.153	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.846	0.154	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.000	0.155	0.845
M06.30 Rheumatoid nodule (Multiple sites)	0.000	0.165	0.835
D86.3 Sarcoidosis of skin	0.829	0.171	0.000
C82.3 Follicular lymphoma grade IIIa	0.000	0.173	0.827
D68.8 Other specified coagulation defects	0.825	0.175	0.000
M14.6 Neuropathic arthropathy	0.000	0.183	0.817
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.000	0.189	0.811
D69.8 Other specified haemorrhagic conditions	0.801	0.199	0.000
C82.1 Mixed small cleaved and large cell, follicular	0.000	0.201	0.799
D55-D59 Haemolytic anaemias	0.792	0.208	0.000
D86.1 Sarcoidosis of lymph nodes	0.791	0.209	0.000
M12 Other specific arthropathies	0.000	0.211	0.789
D69.0 Allergic purpura	0.787	0.213	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.786	0.214	0.000
D60-D64 Aplastic and other anaemias	0.778	0.222	0.000
M05.8 Other seropositive rheumatoid arthritis	0.000	0.229	0.771
E20-E35 Disorders of other endocrine glands	0.770	0.230	0.000
L40.4 Guttate psoriasis	0.000	0.233	0.767
D89.0 Polyclonal hypergammaglobulinaemia	0.766	0.234	0.000
C82.2 Large cell, follicular	0.000	0.237	0.763
E27.2 Addisonian crisis	0.762	0.238	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.252	0.748
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.747	0.253	0.000
M06.04 Seronegative rheumatoid arthritis (Hand)	0.000	0.255	0.745
E00-E07 Disorders of thyroid gland	0.744	0.256	0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.000	0.257	0.743
M06.8 Other specified rheumatoid arthritis	0.000	0.264	0.736
L40.8 Other psoriasis	0.000	0.270	0.730
G35-G37 Demyelinating diseases of the central nervous system	0.729	0.271	0.000
D68.1 Hereditary factor XI deficiency	0.727	0.273	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.725	0.274	0.000
D61 Other aplastic anaemias	0.723	0.277	0.000
D51.8 Other vitamin B12 deficiency anaemias	0.721	0.279	0.000
D82 Immunodeficiency associated with other major defects	0.720	0.279	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.000	0.281	0.719
D69.5 Secondary thrombocytopenia	0.719	0.281	0.000
D68.6 Other Thrombophilia	0.717	0.283	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.000	0.283	0.717
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.283	0.717
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.000	0.283	0.717
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.000	0.283	0.717
M06.2 Rheumatoid bursitis	0.000	0.283	0.717
D81 Combined immunodeficiencies	0.717	0.283	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.000	0.283	0.717
M05.1 Rheumatoid lung disease	0.000	0.283	0.717
M05.0 Felty's syndrome	0.000	0.283	0.717
M09 Juvenile arthritis in diseases classified elsewhere	0.000	0.283	0.717
M08 Juvenile arthritis	0.000	0.283	0.717
E05.5 Thyroid crisis or storm	0.717	0.283	0.000
E05.4 Thyrotoxicosis factitia	0.717	0.283	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.717	0.283	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.717	0.283	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.000	0.283	0.717
M06.38 Rheumatoid nodule (Other)	0.000	0.283	0.717
M06.36 Rheumatoid nodule (Lower leg)	0.000	0.283	0.717
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.000	0.283	0.717
M06.33 Rheumatoid nodule (Forearm)	0.000	0.283	0.717
M06.31 Rheumatoid nodule (Shoulder region)	0.000	0.283	0.717
D86.8 Sarcoidosis of other and combined sites	0.716	0.284	0.000
L40.2 Acrodermatitis continua	0.000	0.284	0.716
M06.08 Seronegative rheumatoid arthritis (Other)	0.000	0.286	0.714
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.000	0.286	0.714
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.000	0.286	0.714
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.000	0.286	0.714
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.000	0.286	0.714
M07.36 Other psoriatic arthropathies (Lower leg)	0.000	0.286	0.714
D68.9 Coagulation defect, unspecified	0.712	0.288	0.000
D83 Common variable immunodeficiency	0.705	0.295	0.000
C82.6 Cutaneous follicle centre lymphoma	0.000	0.298	0.702
C82.5 Diffuse follicle centre lymphoma	0.000	0.298	0.702
K90.3 Pancreatic steatorrhoea	0.698	0.301	0.000
K90.2 Blind loop syndrome, not elsewhere classified	0.698	0.301	0.000
K90.1 Tropical sprue	0.698	0.301	0.000
D68.2 Hereditary deficiency of other clotting factors	0.698	0.302	0.000
L40.1 Generalised pustular psoriasis	0.000	0.305	0.694
D52.8 Other folate deficiency anaemias	0.694	0.306	0.000
D52.1 Drug-induced folate deficiency anaemia	0.694	0.306	0.000
D52.0 Dietary folate deficiency anaemia	0.694	0.306	0.000
C82.4 Follicular lymphoma grade IIIb	0.000	0.306	0.693
D51.2 Transcobalamin II deficiency	0.690	0.310	0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.690	0.310	0.000
E28 Ovarian dysfunction	0.690	0.310	0.000
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.000	0.318	0.682
D89.1 Cryoglobulinaemia	0.679	0.320	0.000
M07.5 Arthropathy in ulcerative colitis	0.000	0.323	0.677
M07.4 Arthropathy in Crohn's disease [regional enteritis]	0.000	0.323	0.677
M07.2 Psoriatic spondylitis	0.000	0.323	0.677
M07.1 Arthritis mutilans	0.000	0.323	0.677
M07.0 Distal interphalangeal psoriatic arthropathy	0.000	0.323	0.677
D61.9 Aplastic anaemia, unspecified	0.674	0.326	0.000
D68.4 Acquired coagulation factor deficiency	0.670	0.330	0.000
D59 Acquired haemolytic anaemia	0.670	0.330	0.000
M06.1 Adult-onset Still's disease	0.000	0.335	0.665
D67 Hereditary factor IX deficiency	0.664	0.335	0.000
D66 Hereditary factor VIII deficiency	0.660	0.340	0.000
M07.6 Other enteropathic arthropathies	0.000	0.342	0.658
M05.2 Rheumatoid vasculitis	0.000	0.342	0.657
D89.2 Hypergammaglobulinaemia, unspecified	0.655	0.345	0.000
G37 Other demyelinating diseases of central nervous system	0.655	0.345	0.000
M14.2 Diabetic arthropathy	0.000	0.347	0.653
M07.30 Other psoriatic arthropathies (Multiple sites)	0.000	0.347	0.652
M07.38 Other psoriatic arthropathies (Other)	0.000	0.350	0.650
M07.33 Other psoriatic arthropathies (Forearm)	0.000	0.350	0.650
M07.32 Other psoriatic arthropathies (Upper arm)	0.000	0.350	0.650
E22 Hyperfunction of pituitary gland	0.650	0.350	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.000	0.351	0.649
D89.3 Immune reconstitution syndrome	0.648	0.352	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.000	0.359	0.641
E27.9 Disorder of adrenal gland, unspecified	0.637	0.363	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.634	0.366	0.000
M14.5 Arthropathies in other endocrine, nutritional and metabolic disorders	0.000	0.368	0.632
M14.4 Arthropathy in amyloidosis	0.000	0.368	0.632
M14.3 Lipoid dermatoarthritis	0.000	0.368	0.632
M14.1 Crystal arthropathy in other metabolic disorders	0.000	0.368	0.632
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.000	0.368	0.632
D53 Other nutritional anaemias	0.631	0.368	0.000
D69.1 Qualitative platelet defects	0.630	0.369	0.000
M07.31 Other psoriatic arthropathies (Shoulder region)	0.000	0.372	0.627
D84 Other immunodeficiencies	0.627	0.373	0.000
M12.3 Palindromic rheumatism	0.000	0.375	0.625
E27.3 Drug-induced adrenocortical insufficiency	0.622	0.378	0.000
E27.5 Adrenomedullary hyperfunction	0.614	0.386	0.000
E27.0 Other adrenocortical overactivity	0.614	0.386	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.000	0.386	0.614
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.000	0.386	0.614
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.000	0.386	0.614
M06.44 Inflammatory polyarthropathy (Hand)	0.000	0.386	0.614
M06.43 Inflammatory polyarthropathy (Forearm)	0.000	0.386	0.614
M06.42 Inflammatory polyarthropathy (Upper arm)	0.000	0.386	0.614
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.000	0.386	0.614
D61.0 Constitutional aplastic anaemia	0.613	0.387	0.000
D51.3 Other dietary vitamin B12 deficiency anaemia	0.609	0.391	0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.000	0.392	0.608
D69.2 Other nonthrombocytopenic purpura	0.607	0.393	0.000
D68.0 Von Willebrand's disease	0.604	0.396	0.000
E31 Polyglandular dysfunction	0.604	0.396	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.601	0.399	0.000
E34 Other endocrine disorders	0.598	0.402	0.000
M07.34 Other psoriatic arthropathies (Hand)	0.000	0.403	0.597
M12.2 Villonodular synovitis (pigmented)	0.000	0.404	0.596
E24 Cushing's syndrome	0.591	0.409	0.000
E28.3 Primary ovarian failure	0.590	0.410	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.588	0.412	0.000
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.000	0.412	0.587
D50 Iron deficiency anaemia	0.586	0.414	0.000
D57 Sickle-cell disorders	0.586	0.414	0.000
L40.3 Pustulosis palmaris et plantaris	0.000	0.416	0.584
D56 Thalassaemia	0.584	0.416	0.000
E05.8 Other thyrotoxicosis	0.578	0.421	0.000
E28.2 Polycystic ovarian syndrome	0.577	0.423	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.572	0.427	0.000
M12.5 Traumatic arthropathy	0.000	0.431	0.569
D55 Anaemia due to enzyme disorders	0.568	0.432	0.000
D59.1 Other autoimmune haemolytic anaemias	0.567	0.433	0.000
E20 Hypoparathyroidism	0.566	0.434	0.000
M12.4 Intermittent hydrarthrosis	0.000	0.434	0.566
M12.1 Kaschin-Beck disease	0.000	0.434	0.566
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.000	0.434	0.566
L40-L45 Papulosquamous disorders	0.032	0.439	0.529
D69.9 Haemorrhagic condition, unspecified	0.558	0.442	0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.000	0.447	0.553
M05.88 Other seropositive rheumatoid arthritis (Other)	0.000	0.447	0.553
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.000	0.447	0.553
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.000	0.447	0.553
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.000	0.447	0.553
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.000	0.447	0.553
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.000	0.447	0.553
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.000	0.447	0.553
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.000	0.447	0.553
E35 Disorders of endocrine glands in diseases classified elsewhere	0.552	0.448	0.000
E32 Diseases of thymus	0.552	0.448	0.000
E30 Disorders of puberty, not elsewhere classified	0.552	0.448	0.000
D80 Immunodeficiency with predominantly antibody defects	0.551	0.449	0.000
M12.8 Other specific arthropathies, not elsewhere classified	0.000	0.450	0.550
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.000	0.453	0.546
E50-E64 Other nutritional deficiencies	0.546	0.454	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.545	0.455	0.000
M11 Other crystal arthropathies	0.000	0.458	0.542
M13 Other arthritis	0.000	0.460	0.540
E07 Other disorders of thyroid	0.540	0.460	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.533	0.467	0.000
E00 Congenital iodine-deficiency syndrome	0.533	0.467	0.000
J32.9 Chronic sinusitis, unspecified	0.000	0.468	0.532
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.528	0.471	0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.000	0.472	0.528
M06.88 Other specified rheumatoid arthritis (Other)	0.000	0.472	0.528
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.000	0.472	0.528
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.000	0.472	0.528
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.000	0.472	0.528
M06.84 Other specified rheumatoid arthritis (Hand)	0.000	0.472	0.528
M06.83 Other specified rheumatoid arthritis (Forearm)	0.000	0.472	0.528
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.000	0.472	0.528
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.000	0.472	0.528
D64 Other anaemias	0.525	0.475	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.000	0.476	0.524
E22.9 Hyperfunction of pituitary gland, unspecified	0.521	0.479	0.000
D82.1 Di George's syndrome	0.520	0.480	0.000
D61.8 Other specified aplastic anaemias	0.519	0.481	0.000
D61.3 Idiopathic aplastic anaemia	0.519	0.481	0.000
D61.2 Aplastic anaemia due to other external agents	0.519	0.481	0.000
D82.9 Immunodeficiency associated with major defect, unspecified	0.517	0.483	0.000
D82.8 Immunodeficiency associated with other specified major defects	0.517	0.483	0.000
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.517	0.483	0.000
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.517	0.483	0.000
D82.2 Immunodeficiency with short-limbed stature	0.517	0.483	0.000
D82.0 Wiskott-Aldrich syndrome	0.517	0.483	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.000	0.486	0.514
M06.28 Rheumatoid bursitis (Other)	0.000	0.486	0.514
M06.27 Rheumatoid bursitis (Ankle and foot)	0.000	0.486	0.514
M06.26 Rheumatoid bursitis (Lower leg)	0.000	0.486	0.514
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.000	0.486	0.514
M06.24 Rheumatoid bursitis (Hand)	0.000	0.486	0.514
M06.23 Rheumatoid bursitis (Forearm)	0.000	0.486	0.514
M06.22 Rheumatoid bursitis (Upper arm)	0.000	0.486	0.514
M06.21 Rheumatoid bursitis (Shoulder region)	0.000	0.486	0.514
M06.20 Rheumatoid bursitis (Multiple sites)	0.000	0.486	0.514
D81.9 Combined immunodeficiency, unspecified	0.514	0.486	0.000
D81.8 Other combined immunodeficiencies	0.514	0.486	0.000
D81.7 Major histocompatibility complex class II deficiency	0.514	0.486	0.000
D81.6 Major histocompatibility complex class I deficiency	0.514	0.486	0.000
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.514	0.486	0.000
D81.4 Nezelof's syndrome	0.514	0.486	0.000
D81.3 Adenosine deaminase [ADA] deficiency	0.514	0.486	0.000
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.514	0.486	0.000
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.514	0.486	0.000
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.514	0.486	0.000
M05.09 Felty's syndrome (Site unspecified)	0.000	0.486	0.514
M05.08 Felty's syndrome (Other)	0.000	0.486	0.514
M05.07 Felty's syndrome (Ankle and foot)	0.000	0.486	0.514
M05.06 Felty's syndrome (Lower leg)	0.000	0.486	0.514
M05.05 Felty's syndrome (Pelvic region and thigh)	0.000	0.486	0.514
M05.04 Felty's syndrome (Hand)	0.000	0.486	0.514
M05.03 Felty's syndrome (Forearm)	0.000	0.486	0.514
M05.02 Felty's syndrome (Upper arm)	0.000	0.486	0.514
M05.01 Felty's syndrome (Shoulder region)	0.000	0.486	0.514
M05.00 Felty's syndrome (Multiple sites)	0.000	0.486	0.514
M05.19 Rheumatoid lung disease (Site unspecified)	0.000	0.486	0.514
M05.18 Rheumatoid lung disease (Other)	0.000	0.486	0.514
M05.17 Rheumatoid lung disease (Ankle and foot)	0.000	0.486	0.514
M05.16 Rheumatoid lung disease (Lower leg)	0.000	0.486	0.514
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.000	0.486	0.514
M05.14 Rheumatoid lung disease (Hand)	0.000	0.486	0.514
M05.13 Rheumatoid lung disease (Forearm)	0.000	0.486	0.514
M05.12 Rheumatoid lung disease (Upper arm)	0.000	0.486	0.514
M05.11 Rheumatoid lung disease (Shoulder region)	0.000	0.486	0.514
M05.10 Rheumatoid lung disease (Multiple sites)	0.000	0.486	0.514
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.000	0.486	0.514
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.000	0.486	0.514
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.000	0.486	0.514
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.000	0.486	0.514
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.000	0.486	0.514
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.000	0.486	0.514
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.000	0.486	0.514
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.000	0.486	0.514
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.000	0.486	0.514
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.000	0.486	0.514
M08.9 Juvenile arthritis, unspecified	0.000	0.486	0.514
M08.8 Other juvenile arthritis	0.000	0.486	0.514
M08.4 Pauciarticular juvenile arthritis	0.000	0.486	0.514
M08.3 Juvenile polyarthritis (seronegative)	0.000	0.486	0.514
M08.2 Juvenile arthritis with systemic onset	0.000	0.486	0.514
M08.1 Juvenile ankylosing spondylitis	0.000	0.486	0.514
M08.0 Juvenile rheumatoid arthritis	0.000	0.486	0.514
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.000	0.486	0.514
M09.2 Juvenile arthritis in ulcerative colitis	0.000	0.486	0.514
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.000	0.486	0.514
M09.0 Juvenile arthritis in psoriasis	0.000	0.486	0.514
E22.0 Acromegaly and pituitary gigantism	0.509	0.491	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.508	0.492	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.506	0.494	0.000
D83.8 Other common variable immunodeficiencies	0.506	0.494	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.506	0.494	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.506	0.494	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.506	0.494	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.499	0.501	0.000
M12.24 Villonodular synovitis (pigmented) (Hand)	0.000	0.502	0.498
E34.0 Carcinoid syndrome	0.498	0.502	0.000
E28.9 Ovarian dysfunction, unspecified	0.495	0.505	0.000
E28.8 Other ovarian dysfunction	0.495	0.505	0.000
E28.1 Androgen excess	0.495	0.505	0.000
E28.0 Oestrogen excess	0.495	0.505	0.000
M12.30 Palindromic rheumatism (Multiple sites)	0.000	0.506	0.494
D83.9 Common variable immunodeficiency, unspecified	0.494	0.506	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.000	0.509	0.491
E07.8 Other specified disorders of thyroid	0.490	0.510	0.000
E24.2 Drug-induced Cushing's syndrome	0.489	0.511	0.000
D73 Diseases of spleen	0.486	0.514	0.000
M07.09 Distal interphalangeal psoriatic arthropathy (Site unspecified)	0.000	0.514	0.485
M07.08 Distal interphalangeal proriatic arthropathy-Other	0.000	0.514	0.485
M07.07 Distal interphalangeal psoriatic arthropathy (Ankle and foot)	0.000	0.514	0.485
M07.06 Distal interphalangeal proriatic arthropathy-Lower leg	0.000	0.514	0.485
M07.05 Distal interphalangeal proriatic arthropathy-Pelvic/thigh	0.000	0.514	0.485
M07.04 Distal interphalangeal psoriatic arthropathy (Hand)	0.000	0.514	0.485
M07.03 Distal interphalangeal proriatic arthropathy-Forearm	0.000	0.514	0.485
M07.02 Distal interphalangeal proriatic arthropathy-Upper arm	0.000	0.514	0.485
M07.01 Distal interphalangeal proriatic arthropathy-Shldr region	0.000	0.514	0.485
M07.00 Distal interphalangeal psoriatic arthropathy (Multiple sites)	0.000	0.514	0.485
M07.19 Arthritis mutilans (Site unspecified)	0.000	0.514	0.485
M07.18 Arthritis mutilans (Other)	0.000	0.514	0.485
M07.17 Arthritis mutilans (Ankle and foot)	0.000	0.514	0.485
M07.16 Arthritis mutilans (Lower leg)	0.000	0.514	0.485
M07.15 Arthritis mutilans (Pelvic region and thigh)	0.000	0.514	0.485
M07.14 Arthritis mutilans (Hand)	0.000	0.514	0.485
M07.13 Arthritis mutilans (Forearm)	0.000	0.514	0.485
M07.12 Arthritis mutilans (Upper arm)	0.000	0.514	0.485
M07.11 Arthritis mutilans (Shoulder region)	0.000	0.514	0.485
M07.10 Arthritis mutilans (Multiple sites)	0.000	0.514	0.485
M07.29 Psoriatic spondylitis (Site unspecified)	0.000	0.514	0.485
M07.28 Psoriatic spondylitis (Other)	0.000	0.514	0.485
M07.27 Psoriatic spondylitis (Ankle and foot)	0.000	0.514	0.485
M07.26 Psoriatic spondylitis (Lower leg)	0.000	0.514	0.485
M07.25 Psoriatic spondylitis (Pelvic region and thigh)	0.000	0.514	0.485
M07.24 Psoriatic spondylitis (Hand)	0.000	0.514	0.485
M07.23 Psoriatic spondylitis (Forearm)	0.000	0.514	0.485
M07.22 Psoriatic spondylitis (Upper arm)	0.000	0.514	0.485
M07.21 Psoriatic spondylitis (Shoulder region)	0.000	0.514	0.485
M07.20 Psoriatic spondylitis (Multiple sites)	0.000	0.514	0.485
M07.49 Arthropathy in Crohn's disease [regional enteritis] (Site unspecified)	0.000	0.514	0.485
M07.48 Arthropathy in Crohn's disease [regional enteritis] (Other)	0.000	0.514	0.485
M07.47 Arthropathy in Crohn's disease [regional enteritis] (Ankle and foot)	0.000	0.514	0.485
M07.46 Arthropathy in Crohn's disease [regional enteritis] (Lower leg)	0.000	0.514	0.485
M07.45 Arthropathy in Crohn's disease [regional enteritis] (Pelvic region and thigh)	0.000	0.514	0.485
M07.44 Arthropathy in Crohn's disease [regional enteritis] (Hand)	0.000	0.514	0.485
M07.43 Arthropathy in Crohn's disease [regional enteritis] (Forearm)	0.000	0.514	0.485
M07.42 Arthropathy in Crohn's disease [regional enteritis] (Upper arm)	0.000	0.514	0.485
M07.41 Arthropathy in Crohn's disease [regional enteritis] (Shoulder region)	0.000	0.514	0.485
M07.40 Arthropathy in Crohn's disease [regional enteritis] (Multiple sites)	0.000	0.514	0.485
M07.59 Arthropathy in ulcerative colitis (Site unspecified)	0.000	0.514	0.485
M07.58 Arthropathy in ulcerative colitis (Other)	0.000	0.514	0.485
M07.57 Arthropathy in ulcerative colitis (Ankle and foot)	0.000	0.514	0.485
M07.56 Arthropathy in ulcerative colitis (Lower leg)	0.000	0.514	0.485
M07.55 Arthropathy in ulcerative colitis (Pelvic region and thigh)	0.000	0.514	0.485
M07.54 Arthropathy in ulcerative colitis (Hand)	0.000	0.514	0.485
M07.53 Arthropathy in ulcerative colitis (Forearm)	0.000	0.514	0.485
M07.52 Arthropathy in ulcerative colitis (Upper arm)	0.000	0.514	0.485
M07.51 Arthropathy in ulcerative colitis (Shoulder region)	0.000	0.514	0.485
M07.50 Arthropathy in ulcerative colitis (Multiple sites)	0.000	0.514	0.485
E31.0 Autoimmune polyglandular failure	0.484	0.516	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.483	0.517	0.000
E22.1 Hyperprolactinaemia	0.482	0.517	0.000
D64.8 Other specified anaemias	0.482	0.518	0.000
D59.8 Other acquired haemolytic anaemias	0.480	0.520	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.480	0.520	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.480	0.520	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.480	0.520	0.000
D59.3 Haemolytic-uraemic syndrome	0.480	0.520	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.480	0.520	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.000	0.523	0.477
M06.18 Adult-onset Still's disease (Other)	0.000	0.523	0.477
M06.17 Adult-onset Still's disease (Ankle and foot)	0.000	0.523	0.477
M06.16 Adult-onset Still's disease (Lower leg)	0.000	0.523	0.477
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.000	0.523	0.477
M06.14 Adult-onset Still's disease (Hand)	0.000	0.523	0.477
M06.13 Adult-onset Still's disease (Forearm)	0.000	0.523	0.477
M06.12 Adult-onset Still's disease (Upper arm)	0.000	0.523	0.477
M06.11 Adult-onset Still's disease (Shoulder region)	0.000	0.523	0.477
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.476	0.524	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.474	0.526	0.000
E40-E46 Malnutrition	0.473	0.527	0.000
M07.68 Other enteropathic arthropathies (Other)	0.000	0.528	0.472
M07.67 Other enteropathic arthropathies (Ankle and foot)	0.000	0.528	0.472
M07.66 Other enteropathic arthropathies (Lower leg)	0.000	0.528	0.472
M07.65 Other enteropathic arthropathies (Pelvic region and thigh)	0.000	0.528	0.472
M07.64 Other enteropathic arthropathies (Hand)	0.000	0.528	0.472
M07.63 Other enteropathic arthropathies (Forearm)	0.000	0.528	0.472
M07.62 Other enteropathic arthropathies (Upper arm)	0.000	0.528	0.472
M07.61 Other enteropathic arthropathies (Shoulder region)	0.000	0.528	0.472
M07.60 Other enteropathic arthropathies (Multiple sites)	0.000	0.528	0.472
M05.28 Rheumatoid vasculitis (Other)	0.000	0.528	0.471
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.000	0.528	0.471
M05.26 Rheumatoid vasculitis (Lower leg)	0.000	0.528	0.471
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.000	0.528	0.471
M05.24 Rheumatoid vasculitis (Hand)	0.000	0.528	0.471
M05.23 Rheumatoid vasculitis (Forearm)	0.000	0.528	0.471
M05.22 Rheumatoid vasculitis (Upper arm)	0.000	0.528	0.471
M05.21 Rheumatoid vasculitis (Shoulder region)	0.000	0.528	0.471
M05.20 Rheumatoid vasculitis (Multiple sites)	0.000	0.528	0.471
D84.1 Defects in the complement system	0.471	0.529	0.000
E27.8 Other specified disorders of adrenal gland	0.470	0.529	0.000
G37.5 Concentric sclerosis [Balo]	0.469	0.531	0.000
G37.4 Subacute necrotising myelitis	0.469	0.531	0.000
G37.2 Central pontine myelinolysis	0.469	0.531	0.000
G37.1 Central demyelination of corpus callosum	0.469	0.531	0.000
G37.0 Diffuse sclerosis	0.469	0.531	0.000
G36 Other acute disseminated demyelination	0.469	0.531	0.000
D58 Other hereditary haemolytic anaemias	0.468	0.532	0.000
D50.9 Iron deficiency anaemia, unspecified	0.467	0.533	0.000
M12.39 Palindromic rheumatism (Site unspecified)	0.000	0.533	0.466
E22.8 Other hyperfunction of pituitary gland	0.466	0.534	0.000
D76.3 Other histiocytosis syndromes	0.466	0.534	0.000
D62 Acute posthaemorrhagic anaemia	0.464	0.536	0.000
E25 Adrenogenital disorders	0.458	0.541	0.000
D50.1 Sideropenic dysphagia	0.455	0.545	0.000
D56.9 Thalassaemia, unspecified	0.453	0.547	0.000
D53.8 Other specified nutritional anaemias	0.453	0.547	0.000
D53.2 Scorbutic anaemia	0.453	0.547	0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.453	0.547	0.000
D53.0 Protein deficiency anaemia	0.453	0.547	0.000
M07.69 Other enteropathic arthropathies (Site unspecified)	0.000	0.547	0.453
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.450	0.550	0.000
M12.38 Palindromic rheumatism (Other)	0.000	0.552	0.448
M12.37 Palindromic rheumatism (Ankle and foot)	0.000	0.552	0.448
M12.36 Palindromic rheumatism (Lower leg)	0.000	0.552	0.448
M12.35 Palindromic rheumatism (Pelvic region and thigh)	0.000	0.552	0.448
M12.34 Palindromic rheumatism (Hand)	0.000	0.552	0.448
M12.33 Palindromic rheumatism (Forearm)	0.000	0.552	0.448
M12.32 Palindromic rheumatism (Upper arm)	0.000	0.552	0.448
M12.31 Palindromic rheumatism (Shoulder region)	0.000	0.552	0.448
D73.5 Infarction of spleen	0.448	0.552	0.000
E24.0 Pituitary-dependent Cushing's disease	0.446	0.554	0.000
E29 Testicular dysfunction	0.443	0.557	0.000
D57.1 Sickle-cell anaemia without crisis	0.439	0.561	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.439	0.561	0.000
M13.1 Monoarthritis, not elsewhere classified	0.000	0.564	0.436
D84.8 Other specified immunodeficiencies	0.434	0.566	0.000
E31.9 Polyglandular dysfunction, unspecified	0.433	0.567	0.000
E31.8 Other polyglandular dysfunction	0.433	0.567	0.000
E31.1 Polyglandular hyperfunction	0.433	0.567	0.000
E10 Insulin-dependent diabetes mellitus	0.000	0.568	0.432
E34.9 Endocrine disorder, unspecified	0.430	0.569	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.430	0.570	0.000
E34.5 Androgen resistance syndrome	0.429	0.571	0.000
E34.4 Constitutional tall stature	0.429	0.571	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.429	0.571	0.000
E34.1 Other hypersecretion of intestinal hormones	0.429	0.571	0.000
M12.29 Villonodular synovitis (pigmented) (Site unspecified)	0.000	0.573	0.427
M12.28 Villonodular synovitis (pigmented) (Other)	0.000	0.573	0.427
M12.27 Villonodular synovitis (pigmented) (Ankle and foot)	0.000	0.573	0.427
M12.25 Villonodular synovitis (pigmented) (Pelvic region and thigh)	0.000	0.573	0.427

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations