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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs537160
log Bayes Factor = 213.027
Chromosome 6   position 31,916,400  (GRCh37) Explore rs537160 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E05.0 Thyrotoxicosis with diffuse goitre
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
M06.9 Rheumatoid arthritis, unspecified
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
G35 Multiple sclerosis
1.000 0.000 0.000
R31 Unspecified haematuria
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
K51 Ulcerative colitis
1.000 0.000 0.000
K90 Intestinal malabsorption
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
1.000 0.000 0.000
G35-G37 Demyelinating diseases of the central nervous system
1.000 0.000 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.000 0.000 1.000
K50-K52 Noninfective enteritis and colitis
1.000 0.000 0.000
Chapter VI Diseases of the nervous system
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
K90-K93 Other diseases of the digestive system
1.000 0.000 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.000 1.000
Chapter I Certain infectious and parasitic diseases
1.000 0.000 0.000
B37.8 Candidiasis of other sites
0.999 0.001 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.001 0.999
T39.1 4-Aminophenol derivatives
0.000 0.001 0.999
K51.9 Ulcerative colitis, unspecified
0.999 0.001 0.000
L40 Psoriasis
0.000 0.001 0.999
B37 Candidiasis
0.999 0.001 0.000
B35-B49 Mycoses
0.999 0.001 0.000
D68 Other coagulation defects
0.998 0.002 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.003 0.997
D69 Purpura and other haemorrhagic conditions
0.996 0.004 0.000
L40.5 Arthropathic psoriasis
0.000 0.004 0.996
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.004 0.996
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.004 0.996
M06 Other rheumatoid arthritis
0.001 0.005 0.995
E04 Other non-toxic goitre
0.992 0.008 0.000
M05 Seropositive rheumatoid arthritis
0.003 0.010 0.987
M05-M14 Inflammatory polyarthropathies
0.008 0.011 0.981
E04.2 Non-toxic multinodular goitre
0.989 0.011 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.988 0.012 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.000 0.012 0.988
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.984 0.016 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.016 0.984
K51.0 Ulcerative (chronic) enterocolitis
0.983 0.017 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.000 0.019 0.981
D80-D89 Certain disorders involving the immune mechanism
0.981 0.019 0.000
B25-B34 Other viral diseases
0.978 0.022 0.000
K52.8 Other specified non-infective gastro-enteritis and colitis
0.977 0.023 0.000
D69.6 Thrombocytopenia, unspecified
0.976 0.024 0.000
K52 Other non-infective gastro-enteritis and colitis
0.976 0.024 0.000
M35.0 Sicca syndrome [Sjogren]
0.976 0.024 0.000
E27.1 Primary adrenocortical insufficiency
0.974 0.026 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.027 0.973
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.028 0.972
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.029 0.971
E50-E64 Other nutritional deficiencies
0.970 0.030 0.000
M35 Other systemic involvement of connective tissue
0.970 0.030 0.000
B25 Cytomegaloviral disease
0.969 0.031 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.032 0.968
M20-M25 Other joint disorders
0.968 0.032 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.967 0.033 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.966 0.034 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.034 0.966
B25.9 Cytomegaloviral disease, unspecified
0.963 0.037 0.000
M06.3 Rheumatoid nodule
0.000 0.037 0.962
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.038 0.962
K90.9 Intestinal malabsorption, unspecified
0.959 0.041 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.957 0.043 0.000
M34 Systemic sclerosis
0.954 0.046 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.953 0.047 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.953 0.047 0.000
T43.2 Other and unspecified antidepressants
0.000 0.052 0.948
E27 Other disorders of adrenal gland
0.947 0.053 0.000
E20-E35 Disorders of other endocrine glands
0.945 0.055 0.000
E78.0 Pure hypercholesterolaemia
0.000 0.061 0.939
B07 Viral warts
0.939 0.061 0.000
L50-L54 Urticaria and erythema
0.938 0.062 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.938 0.062 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.064 0.936
G37 Other demyelinating diseases of central nervous system
0.936 0.064 0.000
D68.2 Hereditary deficiency of other clotting factors
0.930 0.070 0.000
K51.5 Mucosal proctocolitis
0.930 0.070 0.000
K51.4 Pseudopolyposis of colon
0.925 0.075 0.000
L10-L14 Bullous disorders
0.922 0.078 0.000
L52 Erythema nodosum
0.921 0.079 0.000
M23 Internal derangement of knee
0.920 0.080 0.000
K35-K38 Diseases of appendix
0.917 0.083 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.086 0.914
D70-D77 Other diseases of blood and blood-forming organs
0.912 0.088 0.000
M23.4 Loose body in knee
0.911 0.089 0.000
L20-L30 Dermatitis and eczema
0.910 0.090 0.000
D69.5 Secondary thrombocytopenia
0.910 0.090 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.909 0.091 0.000
D86 Sarcoidosis
0.909 0.091 0.000
M06.34 Rheumatoid nodule (Hand)
0.000 0.094 0.906
M00-M03 Infectious arthropathies
0.906 0.094 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.902 0.098 0.000
M23.49 Loose body in knee-Unspec lig/men
0.901 0.099 0.000
G58 Other mononeuropathies
0.895 0.105 0.000
E53 Deficiency of other B group vitamins
0.895 0.105 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.893 0.107 0.000
M34.9 Systemic sclerosis, unspecified
0.889 0.111 0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.888 0.112 0.000
M32 Systemic lupus erythematosus
0.886 0.114 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.885 0.115 0.000
M34.8 Other forms of systemic sclerosis
0.884 0.116 0.000
D80 Immunodeficiency with predominantly antibody defects
0.884 0.116 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.000 0.119 0.881
T39.0 Salicylates
0.000 0.123 0.877
T43.0 Tricyclic and tetracyclic antidepressants
0.000 0.126 0.874
G37.8 Other specified demyelinating diseases of central nervous system
0.874 0.126 0.000
L27 Dermatitis due to substances taken internally
0.873 0.127 0.000
D68.8 Other specified coagulation defects
0.868 0.132 0.000
B37.9 Candidiasis, unspecified
0.867 0.133 0.000
L40.8 Other psoriasis
0.000 0.135 0.865
T46 Poisoning by agents primarily affecting the cardiovascular system
0.000 0.139 0.861
T42.4 Benzodiazepines
0.000 0.139 0.861
L40.0 Psoriasis vulgaris
0.000 0.141 0.859
D86.9 Sarcoidosis, unspecified
0.858 0.142 0.000
L13 Other bullous disorders
0.855 0.145 0.000
K37 Unspecified appendicitis
0.854 0.146 0.000
L27.0 Generalised skin eruption due to drugs and medicaments
0.854 0.146 0.000
G00 Bacterial meningitis, not elsewhere classified
0.851 0.149 0.000
E10-E14 Diabetes mellitus
0.851 0.149 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.846 0.154 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.000 0.155 0.845
D68.5 Primary Thrombophilia
0.843 0.157 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.843 0.157 0.000
M31 Other necrotising vasculopathies
0.841 0.159 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.840 0.160 0.000
G54 Nerve root and plexus disorders
0.839 0.161 0.000
M00 Pyogenic arthritis
0.835 0.165 0.000
T42.1 Iminostilbenes
0.000 0.165 0.835
D68.9 Coagulation defect, unspecified
0.832 0.168 0.000
M32.1 Systemic lupus erythematosus with organ or system involvement
0.830 0.170 0.000
E04.0 Non-toxic diffuse goitre
0.829 0.171 0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.175 0.825
E55 Vitamin D deficiency
0.821 0.179 0.000
A63 Other predominantly sexually transmitted diseases, not elsewhere classified
0.820 0.180 0.000
D68.1 Hereditary factor XI deficiency
0.817 0.183 0.000
L21 Seborrhoeic dermatitis
0.815 0.185 0.000
E61 Deficiency of other nutrient elements
0.814 0.186 0.000
D55-D59 Haemolytic anaemias
0.813 0.187 0.000
G30-G32 Other degenerative diseases of the nervous system
0.811 0.189 0.000
D72 Other disorders of white blood cells
0.811 0.189 0.000
D69.4 Other primary thrombocytopenia
0.810 0.190 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.000 0.191 0.809
G58.8 Other specified mononeuropathies
0.809 0.191 0.000
L13.0 Dermatitis herpetiformis
0.808 0.192 0.000
K90.8 Other intestinal malabsorption
0.804 0.196 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.802 0.198 0.000
M23.8 Other internal derangements of knee
0.801 0.199 0.000
B37.1 Pulmonary candidiasis
0.799 0.201 0.000
D50-D53 Nutritional anaemias
0.799 0.201 0.000
D80.1 Nonfamilial hypogammaglobulinaemia
0.799 0.201 0.000
D69.2 Other nonthrombocytopenic purpura
0.797 0.203 0.000
E53.8 Deficiency of other specified B group vitamins
0.796 0.204 0.000
D69.8 Other specified haemorrhagic conditions
0.796 0.204 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.204 0.796
D70 Agranulocytosis
0.794 0.206 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.000 0.206 0.794
K38 Other diseases of appendix
0.793 0.207 0.000
M23.9 Internal derangement of knee, unspecified
0.790 0.210 0.000
B01 Varicella [chickenpox]
0.788 0.212 0.000
B36 Other superficial mycoses
0.788 0.212 0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.000 0.212 0.788
G00.9 Bacterial meningitis, unspecified
0.785 0.215 0.000
E10 Insulin-dependent diabetes mellitus
0.783 0.217 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.000 0.217 0.783
M02 Reactive arthropathies
0.783 0.217 0.000
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.217 0.783
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.000 0.218 0.782
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.219 0.781
E14 Unspecified diabetes mellitus
0.779 0.221 0.000
M60-M63 Disorders of muscles
0.779 0.221 0.000
L40-L45 Papulosquamous disorders
0.170 0.222 0.608
M34.0 Progressive systemic sclerosis
0.775 0.225 0.000
M31.0 Hypersensitivity angiitis
0.772 0.228 0.000
B37.2 Candidiasis of skin and nail
0.772 0.228 0.000
M00.9 Pyogenic arthritis, unspecified
0.772 0.228 0.000
M35.1 Other overlap syndromes
0.769 0.231 0.000
A63.0 Anogenital (venereal) warts
0.768 0.232 0.000
M35.8 Other specified systemic involvement of connective tissue
0.768 0.232 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.768 0.232 0.000
B08 Other viral infections characterised by skin and mucous membrane lesions, not elsewhere classified
0.767 0.233 0.000
G52 Disorders of other cranial nerves
0.767 0.233 0.000
M35.7 Hypermobility syndrome
0.765 0.235 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.764 0.236 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.237 0.762
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.761 0.239 0.000
L12 Pemphigoid
0.760 0.240 0.000
E31 Polyglandular dysfunction
0.759 0.241 0.000
L40.4 Guttate psoriasis
0.000 0.241 0.759
D68.0 Von Willebrand's disease
0.759 0.241 0.000
E53.9 Vitamin B deficiency, unspecified
0.758 0.242 0.000
D89.0 Polyclonal hypergammaglobulinaemia
0.758 0.242 0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.243 0.757
K91.4 Colostomy and enterostomy malfunction
0.757 0.243 0.000
E14.3 With ophthalmic complications
0.757 0.243 0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.755 0.245 0.000
T43.6 Psychostimulants with abuse potential
0.000 0.248 0.752
G09 Sequelae of inflammatory diseases of central nervous system
0.752 0.248 0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.000 0.248 0.752
E51 Thiamine deficiency
0.749 0.251 0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.251 0.749
D86.1 Sarcoidosis of lymph nodes
0.748 0.252 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.000 0.253 0.747
L21.9 Seborrhoeic dermatitis, unspecified
0.747 0.253 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.746 0.254 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.000 0.254 0.746
E06 Thyroiditis
0.746 0.254 0.000
L40.1 Generalised pustular psoriasis
0.000 0.255 0.745
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.745 0.255 0.000
B37.7 Candidal septicaemia
0.744 0.256 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.000 0.256 0.744
T50.6 Antidotes and chelating agents, not elsewhere classified
0.000 0.257 0.743
E10.2 With renal complications
0.743 0.257 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.000 0.259 0.741
M23.1 Discoid meniscus (congenital)
0.740 0.260 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.262 0.738
D59 Acquired haemolytic anaemia
0.736 0.264 0.000
E10.9 Without complications
0.736 0.264 0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.264 0.736
E27.2 Addisonian crisis
0.734 0.266 0.000
B25.0 Cytomegaloviral pneumonitis
0.734 0.266 0.000
E20 Hypoparathyroidism
0.733 0.267 0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.269 0.731
D72.8 Other specified disorders of white blood cells
0.729 0.271 0.000
M34.1 CR(E)ST syndrome
0.729 0.271 0.000
G20-G26 Extrapyramidal and movement disorders
0.728 0.272 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.725 0.275 0.000
D76.3 Other histiocytosis syndromes
0.724 0.276 0.000
M23.41 Loose body in knee-Ant lig/hrn men
0.723 0.277 0.000
L20 Atopic dermatitis
0.722 0.278 0.000
L11 Other acantholytic disorders
0.722 0.278 0.000
M08 Juvenile arthritis
0.006 0.279 0.715
L26 Exfoliative dermatitis
0.719 0.281 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
K90.3 Pancreatic steatorrhoea
0.717 0.283 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.717 0.283 0.000
K90.1 Tropical sprue
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.000 0.283 0.717
T41 Poisoning by anaesthetics and therapeutic gases
0.000 0.283 0.717
K93 Disorders of other digestive organs in diseases classified elsewhere
0.717 0.283 0.000
T39.4 Antirheumatics, not elsewhere classified
0.000 0.283 0.717
T39.2 Pyrazolone derivatives
0.000 0.283 0.717
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.717 0.283 0.000
A75-A79 Rickettsioses
0.717 0.283 0.000
A70-A74 Other diseases caused by chlamydiae
0.717 0.283 0.000
L40.2 Acrodermatitis continua
0.000 0.284 0.716
B37.6 Candidal endocarditis
0.716 0.284 0.000
B37.5 Candidal meningitis
0.716 0.284 0.000
B48 Other mycoses, not elsewhere classified
0.716 0.284 0.000
B47 Mycetoma
0.716 0.284 0.000
B46 Zygomycosis
0.716 0.284 0.000
B45 Cryptococcosis
0.716 0.284 0.000
B43 Chromomycosis and phaeomycotic abscess
0.716 0.284 0.000
B42 Sporotrichosis
0.716 0.284 0.000
B41 Paracoccidioidomycosis
0.716 0.284 0.000
B40 Blastomycosis
0.716 0.284 0.000
B39 Histoplasmosis
0.716 0.284 0.000
B38 Coccidioidomycosis
0.716 0.284 0.000
B44 Aspergillosis
0.716 0.284 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.716 0.284 0.000
T43.9 Psychotropic drug, unspecified
0.000 0.285 0.715
T43.8 Other psychotropic drugs, not elsewhere classified
0.000 0.285 0.715
D69.1 Qualitative platelet defects
0.714 0.286 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.000 0.286 0.714
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.286 0.714
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.286 0.714
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.286 0.714
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.286 0.714
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.286 0.714
M06.2 Rheumatoid bursitis
0.001 0.286 0.713
E55.9 Vitamin D deficiency, unspecified
0.713 0.287 0.000
D89.1 Cryoglobulinaemia
0.713 0.287 0.000
A65-A69 Other spirochaetal diseases
0.711 0.288 0.000
E04.8 Other specified non-toxic goitre
0.711 0.289 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.710 0.290 0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.003 0.290 0.707
M05.2 Rheumatoid vasculitis
0.003 0.290 0.707
M05.1 Rheumatoid lung disease
0.003 0.290 0.707
M05.0 Felty's syndrome
0.003 0.290 0.707
B50-B64 Protozoal diseases
0.710 0.290 0.000
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.291 0.709
M09 Juvenile arthritis in diseases classified elsewhere
0.006 0.291 0.703
G53 Cranial nerve disorders in diseases classified elsewhere
0.709 0.291 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.709 0.291 0.000
T50.4 Drugs affecting uric acid metabolism
0.000 0.291 0.708
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.000 0.292 0.708
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.000 0.292 0.708
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.000 0.292 0.708
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.000 0.292 0.708
T44.1 Other parasympathomimetics [cholinergics]
0.000 0.292 0.708
T44.0 Anticholinesterase agents
0.000 0.292 0.708
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.706 0.294 0.000
D89.9 Disorder involving the immune mechanism, unspecified
0.706 0.294 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.000 0.294 0.706
A80-A89 Viral infections of the central nervous system
0.705 0.295 0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.705 0.295 0.000
M33 Dermatopolymyositis
0.705 0.295 0.000
T50.7 Analeptics and opioid receptor antagonists
0.000 0.296 0.704
T50.5 Appetite depressants
0.000 0.296 0.704
T50.3 Electrolytic, caloric and water-balance agents
0.000 0.296 0.704
T50.1 Loop [high-ceiling] diuretics
0.000 0.296 0.704
T50.0 Mineralocorticoids and their antagonists
0.000 0.296 0.704
D81 Combined immunodeficiencies
0.704 0.296 0.000
B37.4 Candidiasis of other urogenital sites
0.702 0.298 0.000
B30 Viral conjunctivitis
0.701 0.299 0.000
B26 Mumps
0.701 0.299 0.000
M05.8 Other seropositive rheumatoid arthritis
0.003 0.300 0.697
G54.1 Lumbosacral plexus disorders
0.698 0.302 0.000
A20-A28 Certain zoonotic bacterial diseases
0.696 0.304 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.695 0.304 0.000
E63 Other nutritional deficiencies
0.695 0.304 0.000
E50 Vitamin A deficiency
0.695 0.304 0.000
E60 Dietary zinc deficiency
0.695 0.304 0.000
E59 Dietary selenium deficiency
0.695 0.304 0.000
E54 Ascorbic acid deficiency
0.695 0.304 0.000
E52 Niacin deficiency [pellagra]
0.695 0.304 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.695 0.305 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.695 0.305 0.000
M35.5 Multifocal fibrosclerosis
0.695 0.305 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.695 0.305 0.000
B25.2 Cytomegaloviral pancreatitis
0.695 0.305 0.000
B25.1 Cytomegaloviral hepatitis
0.695 0.305 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.695 0.305 0.000
D86.3 Sarcoidosis of skin
0.693 0.307 0.000
T42.0 Hydantoin derivatives
0.000 0.308 0.692
G04 Encephalitis, myelitis and encephalomyelitis
0.691 0.309 0.000
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.310 0.690
M06.38 Rheumatoid nodule (Other)
0.000 0.310 0.690
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.310 0.690
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.310 0.690
M06.33 Rheumatoid nodule (Forearm)
0.000 0.310 0.690
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.310 0.690
T45.5 Anticoagulants
0.000 0.311 0.689
E61.2 Magnesium deficiency
0.689 0.311 0.000
L51 Erythema multiforme
0.689 0.311 0.000
D66 Hereditary factor VIII deficiency
0.688 0.312 0.000
G54.8 Other nerve root and plexus disorders
0.688 0.312 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.687 0.313 0.000
M07 Psoriatic and enteropathic arthropathies
0.004 0.313 0.683
B06 Rubella [German measles]
0.686 0.314 0.000
B05 Measles
0.686 0.314 0.000
B09 Unspecified viral infection characterised by skin and mucous membrane lesions
0.686 0.314 0.000
B04 Monkeypox
0.686 0.314 0.000
B03 Smallpox
0.686 0.314 0.000
M34.2 Systemic sclerosis induced by drugs and chemicals
0.684 0.316 0.000
E05.8 Other thyrotoxicosis
0.684 0.316 0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.684 0.316 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.000 0.318 0.682
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.000 0.318 0.682
M23.93 Internal derangement of knee, unspecified (Medial collateral ligament or Other and unspecified medial meniscus)
0.682 0.318 0.000
G58.9 Mononeuropathy, unspecified
0.681 0.319 0.000
T38.1 Thyroid hormones and substitutes
0.000 0.319 0.681
K52.3 Indeterminate colitis
0.680 0.320 0.000
L23 Allergic contact dermatitis
0.680 0.320 0.000
B27 Infectious mononucleosis
0.680 0.320 0.000
E27.5 Adrenomedullary hyperfunction
0.679 0.321 0.000
E27.0 Other adrenocortical overactivity
0.679 0.321 0.000
D84 Other immunodeficiencies
0.679 0.321 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.677 0.322 0.000
E32 Diseases of thymus
0.677 0.322 0.000
E30 Disorders of puberty, not elsewhere classified
0.677 0.322 0.000
E25 Adrenogenital disorders
0.677 0.322 0.000
T45.0 Antiallergic and antiemetic drugs
0.000 0.323 0.677
D89.2 Hypergammaglobulinaemia, unspecified
0.677 0.323 0.000
E58 Dietary calcium deficiency
0.676 0.324 0.000
D68.6 Other Thrombophilia
0.676 0.324 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.000 0.324 0.676
E34 Other endocrine disorders
0.676 0.324 0.000
M31.4 Aortic arch syndrome [Takayasu]
0.675 0.325 0.000
M06.1 Adult-onset Still's disease
0.001 0.325 0.674
E56 Other vitamin deficiencies
0.674 0.326 0.000
T50.8 Diagnostic agents
0.000 0.326 0.673
M02.3 Reiter's disease
0.673 0.327 0.000
D50 Iron deficiency anaemia
0.673 0.327 0.000
L54 Erythema in diseases classified elsewhere
0.672 0.327 0.000
G20 Parkinson's disease
0.673 0.327 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.000 0.328 0.671
T42.3 Barbiturates
0.000 0.328 0.671
T42.2 Succinimides and oxazolidinediones
0.000 0.328 0.671
G58.0 Intercostal neuropathy
0.671 0.329 0.000
G37.5 Concentric sclerosis [Balo]
0.671 0.329 0.000
G37.4 Subacute necrotising myelitis
0.671 0.329 0.000
G37.2 Central pontine myelinolysis
0.671 0.329 0.000
G37.1 Central demyelination of corpus callosum
0.671 0.329 0.000
G37.0 Diffuse sclerosis
0.671 0.329 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.669 0.331 0.000
M23.40 Loose body in knee-Mult sites
0.668 0.332 0.000
A15-A19 Tuberculosis
0.667 0.333 0.000
M60 Myositis
0.666 0.334 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.000 0.336 0.664
K36 Other appendicitis
0.663 0.337 0.000
L50 Urticaria
0.662 0.338 0.000
L10 Pemphigus
0.661 0.339 0.000
L14 Bullous disorders in diseases classified elsewhere
0.661 0.339 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.660 0.340 0.000
G00.2 Streptococcal meningitis
0.660 0.340 0.000
G00.1 Pneumococcal meningitis
0.659 0.341 0.000
M23.44 Loose body in knee-Lat lig/ant men
0.659 0.341 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.659 0.341 0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)
0.657 0.343 0.000
B33 Other viral diseases, not elsewhere classified
0.657 0.343 0.000
D67 Hereditary factor IX deficiency
0.656 0.344 0.000
M23.43 Loose body in knee-Med lig/oth men
0.655 0.345 0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue
0.654 0.346 0.000
B25.8 Other cytomegaloviral diseases
0.654 0.346 0.000
D74 Methaemoglobinaemia
0.654 0.346 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.654 0.346 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.654 0.346 0.000
D83 Common variable immunodeficiency
0.653 0.346 0.000
M23.47 Loose body in knee-Capsular lig
0.653 0.347 0.000
M23.45 Loose body in knee-Pst hrn lat men
0.653 0.347 0.000
M23.42 Loose body in knee-Pst lig/hrn men
0.653 0.347 0.000
L24 Irritant contact dermatitis
0.653 0.347 0.000
L22 Diaper [napkin] dermatitis
0.653 0.347 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.652 0.348 0.000
K38.8 Other specified diseases of appendix
0.651 0.349 0.000
M31.3 Wegener's granulomatosis
0.650 0.350 0.000
M23.5 Chronic instability of knee
0.650 0.350 0.000
K51.8 Other ulcerative colitis
0.650 0.350 0.000
M23.46 Loose body in knee-O/unsp lat men
0.650 0.350 0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere
0.649 0.350 0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere
0.649 0.350 0.000
M00.93 Pyogenic arthritis, unspecified (Forearm)
0.649 0.351 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.649 0.351 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.649 0.351 0.000
M00.0 Staphylococcal arthritis and polyarthritis
0.647 0.353 0.000
D68.4 Acquired coagulation factor deficiency
0.647 0.353 0.000
M00.96 Pyogenic arthritis, unspecified (Lower leg)
0.647 0.353 0.000
G36 Other acute disseminated demyelination
0.647 0.353 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.000 0.354 0.646
K51.1 Ulcerative (chronic) ileocolitis
0.645 0.355 0.000
M31.1 Thrombotic microangiopathy
0.645 0.355 0.000
L12.0 Bullous pemphigoid
0.643 0.357 0.000
G31.9 Degenerative disease of nervous system, unspecified
0.643 0.357 0.000
M31.8 Other specified necrotising vasculopathies
0.643 0.357 0.000
E53.1 Pyridoxine deficiency
0.642 0.358 0.000
E53.0 Riboflavin deficiency
0.642 0.358 0.000
T36 Poisoning by systemic antibiotics
0.000 0.359 0.641
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.641 0.359 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.359 0.640
K38.9 Disease of appendix, unspecified
0.640 0.360 0.000
D82 Immunodeficiency associated with other major defects
0.639 0.361 0.000
M40-M43 Deforming dorsopathies
0.637 0.363 0.000
D89.3 Immune reconstitution syndrome
0.637 0.363 0.000
B65-B83 Helminthiases
0.637 0.363 0.000
B36.9 Superficial mycosis, unspecified
0.637 0.363 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.636 0.364 0.000
M32.9 Systemic lupus erythematosus, unspecified
0.635 0.365 0.000
M32.0 Drug-induced systemic lupus erythematosus
0.635 0.365 0.000
A59 Trichomoniasis
0.634 0.365 0.000
A56 Other sexually transmitted chlamydial diseases
0.634 0.365 0.000
A54 Gonococcal infection
0.634 0.365 0.000
A53 Other and unspecified syphilis
0.634 0.365 0.000
A52 Late syphilis
0.634 0.365 0.000
A51 Early syphilis
0.634 0.365 0.000
A50 Congenital syphilis
0.634 0.365 0.000
A64 Unspecified sexually transmitted disease
0.634 0.365 0.000
A58 Granuloma inguinale
0.634 0.365 0.000
A57 Chancroid
0.634 0.365 0.000
A55 Chlamydial lymphogranuloma (venereum)
0.634 0.365 0.000
G58.7 Mononeuritis multiplex
0.634 0.366 0.000
D80.8 Other immunodeficiencies with predominantly antibody defects
0.634 0.366 0.000
D80.7 Transient hypogammaglobulinaemia of infancy
0.634 0.366 0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.634 0.366 0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.634 0.366 0.000
D80.0 Hereditary hypogammaglobulinaemia
0.634 0.366 0.000
B01.2 Varicella pneumonia
0.633 0.367 0.000
T38.9 Other and unspecified hormone antagonists
0.000 0.368 0.632
T38.8 Other and unspecified hormones and their synthetic substitutes
0.000 0.368 0.632
T38.7 Androgens and anabolic congeners
0.000 0.368 0.632
T38.5 Other oestrogens and progestogens
0.000 0.368 0.632
T38.4 Oral contraceptives
0.000 0.368 0.632
T38.2 Antithyroid drugs
0.000 0.368 0.632
T38.0 Glucocorticoids and synthetic analogues
0.000 0.368 0.632
D59.1 Other autoimmune haemolytic anaemias
0.632 0.368 0.000
B08.1 Molluscum contagiosum
0.631 0.369 0.000
E31.0 Autoimmune polyglandular failure
0.627 0.373 0.000
L27.9 Dermatitis due to unspecified substance taken internally
0.626 0.374 0.000
L27.8 Dermatitis due to other substances taken internally
0.626 0.374 0.000
D59.9 Acquired haemolytic anaemia, unspecified
0.626 0.374 0.000
L53 Other erythematous conditions
0.626 0.374 0.000
M35.2 Behcet's disease
0.625 0.375 0.000
G54.2 Cervical root disorders, not elsewhere classified
0.625 0.375 0.000
D69.9 Haemorrhagic condition, unspecified
0.623 0.376 0.000
E28 Ovarian dysfunction
0.623 0.377 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.622 0.378 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.378 0.622
G70-G73 Diseases of myoneural junction and muscle
0.621 0.379 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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