TreeWAS – Variant ID: rs6131

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
D68.2 Hereditary deficiency of other clotting factors	1.000	0.000	0.000
D68 Other coagulation defects	0.875	0.125	0.000
D68.5 Primary Thrombophilia	0.837	0.163	0.000
D68.4 Acquired coagulation factor deficiency	0.731	0.269	0.000
D68.6 Other Thrombophilia	0.645	0.355	0.000
D68.1 Hereditary factor XI deficiency	0.639	0.361	0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.634	0.365	0.000
D68.8 Other specified coagulation defects	0.614	0.386	0.000
D68.0 Von Willebrand's disease	0.609	0.391	0.000
D68.9 Coagulation defect, unspecified	0.528	0.472	0.000
M79.86 Other specified soft tissue disorders (Lower leg)	0.266	0.734	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.150	0.850	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.109	0.891	0.000
D67 Hereditary factor IX deficiency	0.108	0.892	0.000
D66 Hereditary factor VIII deficiency	0.098	0.902	0.000
D69 Purpura and other haemorrhagic conditions	0.020	0.980	0.001
S82.10 Fracture of upper end of tibia (closed)	0.020	0.980	0.000
S82.1 Fracture of upper end of tibia	0.017	0.983	0.000
B37.8 Candidiasis of other sites	0.017	0.983	0.000
S81.9 Open wound of lower leg, part unspecified	0.017	0.983	0.000
D69.9 Haemorrhagic condition, unspecified	0.016	0.984	0.000
D69.2 Other nonthrombocytopenic purpura	0.015	0.984	0.000
S81 Open wound of lower leg	0.015	0.985	0.000
D69.8 Other specified haemorrhagic conditions	0.014	0.985	0.001
D69.1 Qualitative platelet defects	0.014	0.985	0.001
S82 Fracture of lower leg, including ankle	0.014	0.986	0.000
M79.8 Other specified soft tissue disorders	0.014	0.986	0.000
S81.0 Open wound of knee	0.014	0.986	0.000
S82.11 Fracture of upper end of tibia (open)	0.014	0.986	0.000
D69.0 Allergic purpura	0.013	0.987	0.001
S80-S89 Injuries to the knee and lower leg	0.013	0.987	0.000
T93.2 Sequelae of other fractures of lower limb	0.013	0.987	0.000
M79.89 Other specified soft tissue disorders (Site unspecified)	0.013	0.987	0.000
D69.4 Other primary thrombocytopenia	0.012	0.987	0.001
S82.3 Fracture of lower end of tibia	0.013	0.987	0.000
S02.40 Fracture of malar and maxillary bones (closed)	0.013	0.987	0.000
D69.5 Secondary thrombocytopenia	0.011	0.988	0.001
S82.7 Multiple fractures of lower leg	0.012	0.988	0.000
S82.2 Fracture of shaft of tibia	0.012	0.988	0.000
S82.30 Fracture of lower end of tibia (closed)	0.011	0.989	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.011	0.989	0.000
S82.9 Fracture of lower leg, part unspecified	0.011	0.989	0.000
S82.5 Fracture of medial malleolus	0.011	0.989	0.000
S81.7 Multiple open wounds of lower leg	0.011	0.989	0.000
M79.85 Other specified soft tissue disorders (Pelvic region and thigh)	0.010	0.989	0.000
M79.81 Other specified soft tissue disorders (Shoulder region)	0.010	0.990	0.000
S82.20 Fracture of shaft of tibia (closed)	0.010	0.990	0.000
M79.65 Pain in limb (Pelvic region and thigh)	0.010	0.990	0.000
S83.7 Injury to multiple structures of knee	0.010	0.990	0.000
S82.70 Multiple fractures of lower leg (closed)	0.010	0.990	0.000
S82.31 Fracture of lower end of tibia (open)	0.010	0.990	0.000
S88 Traumatic amputation of lower leg	0.010	0.990	0.000
S87 Crushing injury of lower leg	0.010	0.990	0.000
S85 Injury of blood vessels at lower leg level	0.010	0.990	0.000
S84 Injury of nerves at lower leg level	0.010	0.990	0.000
R00.1 Bradycardia, unspecified	0.000	0.990	0.010
S89 Other and unspecified injuries of lower leg	0.010	0.990	0.000
S86 Injury of muscle and tendon at lower leg level	0.009	0.990	0.000
T93 Sequelae of injuries of lower limb	0.010	0.990	0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.009	0.990	0.000
S83.3 Tear of articular cartilage of knee, current	0.009	0.991	0.000
S82.4 Fracture of fibula alone	0.009	0.991	0.000
B37 Candidiasis	0.009	0.991	0.000
S82.71 Multiple fractures of lower leg (open)	0.009	0.991	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.009	0.991	0.000
S82.90 Fracture of lower leg, part unspecified (closed)	0.008	0.991	0.000
M79.87 Other specified soft tissue disorders (Ankle and foot)	0.008	0.992	0.000
Y86 Sequelae of other accidents	0.008	0.992	0.000
M79.83 Other specified soft tissue disorders (Forearm)	0.008	0.992	0.000
S81.8 Open wound of other parts of lower leg	0.008	0.992	0.000
S83.1 Dislocation of knee	0.008	0.992	0.000
S83.0 Dislocation of patella	0.008	0.992	0.000
S80 Superficial injury of lower leg	0.008	0.992	0.000
S82.50 Fracture of medial malleolus (closed)	0.008	0.992	0.000
S82.91 Fracture of lower leg, part unspecified (open)	0.008	0.992	0.000
T93.1 Sequelae of fracture of femur	0.008	0.992	0.000
T93.9 Sequelae of unspecified injury of lower limb	0.008	0.992	0.000
S82.51 Fracture of medial malleolus (open)	0.008	0.992	0.000
S82.6 Fracture of lateral malleolus	0.008	0.992	0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.008	0.992	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.008	0.992	0.000
B37.7 Candidal septicaemia	0.008	0.992	0.000
T93.8 Sequelae of other specified injuries of lower limb	0.008	0.992	0.000
E27.1 Primary adrenocortical insufficiency	0.008	0.992	0.000
S82.21 Fracture of shaft of tibia (open)	0.007	0.992	0.000
S83.2 Tear of meniscus, current	0.007	0.993	0.000
S89.9 Unspecified injury of lower leg	0.007	0.993	0.000
B35-B49 Mycoses	0.007	0.993	0.000
S84.9 Injury of unspecified nerve at lower leg level	0.007	0.993	0.000
S84.8 Injury of other nerves at lower leg level	0.007	0.993	0.000
S84.7 Injury of multiple nerves at lower leg level	0.007	0.993	0.000
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.007	0.993	0.000
S84.1 Injury of peroneal nerve at lower leg level	0.007	0.993	0.000
S84.0 Injury of tibial nerve at lower leg level	0.007	0.993	0.000
S85.9 Injury of unspecified blood vessel at lower leg level	0.007	0.993	0.000
S85.8 Injury of other blood vessels at lower leg level	0.007	0.993	0.000
S85.7 Injury of multiple blood vessels at lower leg level	0.007	0.993	0.000
S85.5 Injury of popliteal vein	0.007	0.993	0.000
S85.4 Injury of lesser saphenous vein at lower leg level	0.007	0.993	0.000
S85.3 Injury of greater saphenous vein at lower leg level	0.007	0.993	0.000
S85.2 Injury of peroneal artery	0.007	0.993	0.000
S85.1 Injury of (anterior)(posterior) tibial artery	0.007	0.993	0.000
S85.0 Injury of popliteal artery	0.007	0.993	0.000
S87.8 Crushing injury of other and unspecified parts of lower leg	0.007	0.993	0.000
S87.0 Crushing injury of knee	0.007	0.993	0.000
S88.9 Traumatic amputation of lower leg, level unspecified	0.007	0.993	0.000
S88.1 Traumatic amputation at level between knee and ankle	0.007	0.993	0.000
S88.0 Traumatic amputation at knee level	0.007	0.993	0.000
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.007	0.993	0.000
S83.6 Sprain and strain of other and unspecified parts of knee	0.007	0.993	0.000
S89.7 Multiple injuries of lower leg	0.007	0.993	0.000
S89.1 Other specified injuries of lower leg	0.007	0.993	0.000
S89.0 Multiple injuries of lower leg	0.007	0.993	0.000
S86.0 Injury of Achilles tendon	0.007	0.993	0.000
S86.7 Injury of multiple muscles and tendons at lower leg level	0.007	0.993	0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.007	0.993	0.000
M79.82 Other specified soft tissue disorders (Upper arm)	0.007	0.993	0.000
T93.6 Sequelae of crushing injury and traumatic amputation of lower limb	0.007	0.993	0.000
T93.4 Sequelae of injury of nerve of lower limb	0.007	0.993	0.000
B37.1 Pulmonary candidiasis	0.007	0.993	0.000
M79.80 Other specified soft tissue disorders (Multiple sites)	0.007	0.993	0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.007	0.993	0.000
D55-D59 Haemolytic anaemias	0.007	0.993	0.000
B37.3 Candidiasis of vulva and vagina	0.007	0.993	0.000
S82.0 Fracture of patella	0.007	0.993	0.000
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.007	0.993	0.000
S82.41 Fracture of fibula alone (open)	0.007	0.993	0.000
S82.8 Fractures of other parts of lower leg	0.007	0.993	0.000
M79.88 Other specified soft tissue disorders (Other)	0.006	0.993	0.001
B44 Aspergillosis	0.007	0.993	0.000
S80.0 Contusion of knee	0.007	0.993	0.000
S89.8 Other specified injuries of lower leg	0.006	0.993	0.000
B37.2 Candidiasis of skin and nail	0.007	0.993	0.000
B49 Unspecified mycosis	0.007	0.993	0.000
B37.6 Candidal endocarditis	0.006	0.993	0.000
B37.5 Candidal meningitis	0.006	0.993	0.000
B35 Dermatophytosis	0.006	0.994	0.000
E27 Other disorders of adrenal gland	0.006	0.994	0.000
S80.7 Multiple superficial injuries of lower leg	0.006	0.994	0.000
S80.9 Superficial injury of lower leg, unspecified	0.006	0.994	0.000
M79.84 Other specified soft tissue disorders (Hand)	0.006	0.994	0.000
B35.3 Tinea pedis	0.006	0.994	0.000
T93.0 Sequelae of open wound of lower limb	0.006	0.994	0.000
B44.9 Aspergillosis, unspecified	0.006	0.994	0.000
C25.9 Pancreas, unspecified	0.006	0.994	0.000
D58 Other hereditary haemolytic anaemias	0.006	0.994	0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.006	0.994	0.000
S82.61 Fracture of lateral malleolus (open)	0.006	0.994	0.000
S02.4 Fracture of malar and maxillary bones	0.006	0.994	0.000
B44.1 Other pulmonary aspergillosis	0.006	0.994	0.000
S80.1 Contusion of other and unspecified parts of lower leg	0.006	0.994	0.000
B48 Other mycoses, not elsewhere classified	0.005	0.994	0.000
B47 Mycetoma	0.005	0.994	0.000
B46 Zygomycosis	0.005	0.994	0.000
B45 Cryptococcosis	0.005	0.994	0.000
B43 Chromomycosis and phaeomycotic abscess	0.005	0.994	0.000
B42 Sporotrichosis	0.005	0.994	0.000
B41 Paracoccidioidomycosis	0.005	0.994	0.000
B40 Blastomycosis	0.005	0.994	0.000
B39 Histoplasmosis	0.005	0.994	0.000
B38 Coccidioidomycosis	0.005	0.994	0.000
E61.1 Iron deficiency	0.005	0.995	0.000
T78.4 Allergy, unspecified	0.005	0.995	0.000
B36 Other superficial mycoses	0.005	0.995	0.000
D56 Thalassaemia	0.005	0.995	0.000
S82.40 Fracture of fibula alone (closed)	0.005	0.995	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.005	0.995	0.000
S86.00 Unspecified injury of Achilles tendon	0.005	0.995	0.000
B35.6 Tinea cruris	0.005	0.995	0.000
D58.0 Hereditary spherocytosis	0.005	0.995	0.000
B37.4 Candidiasis of other urogenital sites	0.005	0.995	0.000
D57 Sickle-cell disorders	0.005	0.995	0.000
D55 Anaemia due to enzyme disorders	0.005	0.995	0.000
D73 Diseases of spleen	0.005	0.995	0.000
S82.86 Maisonneuve's fracture	0.005	0.995	0.000
B44.8 Other forms of aspergillosis	0.005	0.995	0.000
B44.7 Disseminated aspergillosis	0.005	0.995	0.000
B44.2 Tonsillar aspergillosis	0.005	0.995	0.000
B44.0 Invasive pulmonary aspergillosis	0.005	0.995	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.005	0.995	0.000
E20-E35 Disorders of other endocrine glands	0.005	0.995	0.000
E27.4 Other and unspecified adrenocortical insufficiency	0.005	0.995	0.000
N64.5 Other signs and symptoms in breast	0.000	0.995	0.005
S86.8 Injury of other muscles and tendons at lower leg level	0.005	0.995	0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.005	0.995	0.000
B35.9 Dermatophytosis, unspecified	0.005	0.995	0.000
B35.8 Other dermatophytoses	0.005	0.995	0.000
B35.5 Tinea imbricata	0.005	0.995	0.000
B35.4 Tinea corporis	0.005	0.995	0.000
B35.2 Tinea manuum	0.005	0.995	0.000
B35.0 Tinea barbae and tinea capitis	0.005	0.995	0.000
E27.5 Adrenomedullary hyperfunction	0.005	0.995	0.000
E27.0 Other adrenocortical overactivity	0.005	0.995	0.000
C25 Malignant neoplasm of pancreas	0.005	0.995	0.000
S82.01 Fracture of patella (open)	0.004	0.995	0.000
E26 Hyperaldosteronism	0.005	0.995	0.000
E27.2 Addisonian crisis	0.005	0.995	0.000
E27.8 Other specified disorders of adrenal gland	0.005	0.995	0.000
E27.9 Disorder of adrenal gland, unspecified	0.005	0.995	0.000
W25.9 Unspecified place	0.005	0.995	0.000
T78 Adverse effects, not elsewhere classified	0.005	0.995	0.000
E23 Hypofunction and other disorders of pituitary gland	0.005	0.995	0.000
D73.5 Infarction of spleen	0.005	0.995	0.000
C25.4 Endocrine pancreas	0.005	0.995	0.000
D58.8 Other specified hereditary haemolytic anaemias	0.004	0.995	0.000
D58.2 Other haemoglobinopathies	0.004	0.995	0.000
D58.1 Hereditary elliptocytosis	0.004	0.995	0.000
D59 Acquired haemolytic anaemia	0.004	0.995	0.000
D73.0 Hyposplenism	0.005	0.995	0.000
T78.8 Other adverse effects, not elsewhere classified	0.004	0.995	0.000
D58.9 Hereditary haemolytic anaemia, unspecified	0.004	0.996	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.003	0.996	0.001
D73.3 Abscess of spleen	0.004	0.996	0.000
X41.9 Unspecified place	0.004	0.996	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.004	0.996	0.000
S02.41 Fracture of malar and maxillary bones (open)	0.004	0.996	0.000
E26.9 Hyperaldosteronism, unspecified	0.004	0.996	0.000
D80-D89 Certain disorders involving the immune mechanism	0.004	0.996	0.000
C25.3 Pancreatic duct	0.004	0.996	0.000
D56.3 Thalassaemia trait	0.004	0.996	0.000
E24 Cushing's syndrome	0.004	0.996	0.000
E23.0 Hypopituitarism	0.004	0.996	0.000
B38.9 Coccidioidomycosis, unspecified	0.004	0.996	0.000
B38.8 Other forms of coccidioidomycosis	0.004	0.996	0.000
B38.7 Disseminated coccidioidomycosis	0.004	0.996	0.000
B38.4 Coccidioidomycosis meningitis	0.004	0.996	0.000
B38.3 Cutaneous coccidioidomycosis	0.004	0.996	0.000
B38.2 Pulmonary coccidioidomycosis, unspecified	0.004	0.996	0.000
B38.1 Chronic pulmonary coccidioidomycosis	0.004	0.996	0.000
B38.0 Acute pulmonary coccidioidomycosis	0.004	0.996	0.000
B39.9 Histoplasmosis, unspecified	0.004	0.996	0.000
B39.5 Histoplasmosis duboisii	0.004	0.996	0.000
B39.4 Histoplasmosis capsulati, unspecified	0.004	0.996	0.000
B39.3 Disseminated histoplasmosis capsulati	0.004	0.996	0.000
B39.2 Pulmonary histoplasmosis capsulati, unspecified	0.004	0.996	0.000
B39.1 Chronic pulmonary histoplasmosis capsulati	0.004	0.996	0.000
B39.0 Acute pulmonary histoplasmosis capsulati	0.004	0.996	0.000
B40.9 Blastomycosis, unspecified	0.004	0.996	0.000
B40.8 Other forms of blastomycosis	0.004	0.996	0.000
B40.7 Disseminated blastomycosis	0.004	0.996	0.000
B40.3 Cutaneous blastomycosis	0.004	0.996	0.000
B40.2 Pulmonary blastomycosis, unspecified	0.004	0.996	0.000
B40.1 Chronic pulmonary blastomycosis	0.004	0.996	0.000
B40.0 Acute pulmonary blastomycosis	0.004	0.996	0.000
B41.9 Paracoccidioidomycosis, unspecified	0.004	0.996	0.000
B41.8 Other forms of paracoccidioidomycosis	0.004	0.996	0.000
B41.7 Disseminated paracoccidioidomycosis	0.004	0.996	0.000
B41.0 Pulmonary paracoccidioidomycosis	0.004	0.996	0.000
B42.9 Sporotrichosis, unspecified	0.004	0.996	0.000
B42.8 Other forms of sporotrichosis	0.004	0.996	0.000
B42.7 Disseminated sporotrichosis	0.004	0.996	0.000
B42.1 Lymphocutaneous sporotrichosis	0.004	0.996	0.000
B42.0 Pulmonary sporotrichosis	0.004	0.996	0.000
B43.9 Chromomycosis, unspecified	0.004	0.996	0.000
B43.8 Other forms of chromomycosis	0.004	0.996	0.000
B43.2 Subcutaneous phaeomycotic abscess and cyst	0.004	0.996	0.000
B43.1 Phaeomycotic brain abscess	0.004	0.996	0.000
B43.0 Cutaneous chromomycosis	0.004	0.996	0.000
B45.9 Cryptococcosis, unspecified	0.004	0.996	0.000
B45.8 Other forms of cryptococcosis	0.004	0.996	0.000
B45.7 Disseminated cryptococcosis	0.004	0.996	0.000
B45.3 Osseous cryptococcosis	0.004	0.996	0.000
B45.2 Cutaneous cryptococcosis	0.004	0.996	0.000
B45.1 Cerebral cryptococcosis	0.004	0.996	0.000
B45.0 Pulmonary cryptococcosis	0.004	0.996	0.000
B46.9 Zygomycosis, unspecified	0.004	0.996	0.000
B46.8 Other zygomycoses	0.004	0.996	0.000
B46.5 Mucormycosis, unspecified	0.004	0.996	0.000
B46.4 Disseminated mucormycosis	0.004	0.996	0.000
B46.3 Cutaneous mucormycosis	0.004	0.996	0.000
B46.2 Gastro-intestinal mucormycosis	0.004	0.996	0.000
B46.1 Rhinocerebral mucormycosis	0.004	0.996	0.000
B46.0 Pulmonary mucormycosis	0.004	0.996	0.000
B47.9 Mycetoma, unspecified	0.004	0.996	0.000
B47.1 Actinomycetoma	0.004	0.996	0.000
B47.0 Eumycetoma	0.004	0.996	0.000
B48.8 Other specified mycoses	0.004	0.996	0.000
B48.7 Opportunistic mycoses	0.004	0.996	0.000
B48.4 Penicillosis	0.004	0.996	0.000
B48.3 Geotrichosis	0.004	0.996	0.000
B48.2 Allescheriasis	0.004	0.996	0.000
B48.1 Rhinosporidiosis	0.004	0.996	0.000
B48.0 Lobomycosis	0.004	0.996	0.000
C25.0 Head of pancreas	0.004	0.996	0.000
D73.4 Cyst of spleen	0.004	0.996	0.000
B36.8 Other specified superficial mycoses	0.004	0.996	0.000
B36.3 Black piedra	0.004	0.996	0.000
B36.2 White piedra	0.004	0.996	0.000
B36.1 Tinea nigra	0.004	0.996	0.000
B36.0 Pityriasis versicolor	0.004	0.996	0.000
Y85 Sequelae of transport accidents	0.004	0.996	0.000
D56.9 Thalassaemia, unspecified	0.004	0.996	0.000
D56.8 Other thalassaemias	0.004	0.996	0.000
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.004	0.996	0.000
D56.2 Delta-beta thalassaemia	0.004	0.996	0.000
D56.1 Beta thalassaemia	0.004	0.996	0.000
D56.0 Alpha thalassaemia	0.004	0.996	0.000
E26.0 Primary hyperaldosteronism	0.004	0.996	0.000
Y85.9 Sequelae of other and unspecified transport accidents	0.004	0.996	0.000
B36.9 Superficial mycosis, unspecified	0.004	0.996	0.000
E23.7 Disorder of pituitary gland, unspecified	0.004	0.996	0.000
C25.1 Body of pancreas	0.004	0.996	0.000
D50-D53 Nutritional anaemias	0.004	0.996	0.000
D55.9 Anaemia due to enzyme disorder, unspecified	0.004	0.996	0.000
D55.8 Other anaemias due to enzyme disorders	0.004	0.996	0.000
D55.3 Anaemia due to disorders of nucleotide metabolism	0.004	0.996	0.000
D55.2 Anaemia due to disorders of glycolytic enzymes	0.004	0.996	0.000
D55.1 Anaemia due to other disorders of glutathione metabolism	0.004	0.996	0.000
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.004	0.996	0.000
D57.8 Other sickle-cell disorders	0.004	0.996	0.000
D57.3 Sickle-cell trait	0.004	0.996	0.000
D57.2 Double heterozygous sickling disorders	0.004	0.996	0.000
D57.1 Sickle-cell anaemia without crisis	0.004	0.996	0.000
D57.0 Sickle-cell anaemia with crisis	0.004	0.996	0.000
B37.9 Candidiasis, unspecified	0.004	0.996	0.000
D73.9 Disease of spleen, unspecified	0.004	0.996	0.000
D73.8 Other diseases of spleen	0.004	0.996	0.000
D73.2 Chronic congestive splenomegaly	0.004	0.996	0.000
D73.1 Hypersplenism	0.004	0.996	0.000
E21.3 Hyperparathyroidism, unspecified	0.004	0.996	0.000
Y40.3 Macrolides	0.004	0.996	0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified	0.004	0.996	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.004	0.996	0.000
S82.80 Fractures of other parts of lower leg (closed)	0.004	0.996	0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.004	0.996	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.004	0.996	0.000
C25.7 Other parts of pancreas	0.004	0.996	0.000
S80.8 Other superficial injuries of lower leg	0.004	0.996	0.000
D74 Methaemoglobinaemia	0.004	0.996	0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.004	0.996	0.000
D71 Functional disorders of polymorphonuclear neutrophils	0.004	0.996	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.004	0.996	0.000
E32 Diseases of thymus	0.004	0.996	0.000
E31 Polyglandular dysfunction	0.004	0.996	0.000
E30 Disorders of puberty, not elsewhere classified	0.004	0.996	0.000
E25 Adrenogenital disorders	0.004	0.996	0.000
E24.9 Cushing's syndrome, unspecified	0.004	0.996	0.000
T78.1 Other adverse food reactions, not elsewhere classified	0.004	0.996	0.000
T78.0 Anaphylactic shock due to adverse food reaction	0.004	0.996	0.000
C25.8 Overlapping lesion of pancreas	0.004	0.996	0.000
T90 Sequelae of injuries of head	0.004	0.996	0.000
E26.8 Other hyperaldosteronism	0.004	0.996	0.000
E26.1 Secondary hyperaldosteronism	0.004	0.996	0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.004	0.996	0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.000	0.996	0.004
E28 Ovarian dysfunction	0.004	0.996	0.000
Y89 Sequelae of other external causes	0.004	0.996	0.000
X40-X49 Accidental poisoning by and exposure to noxious substances	0.004	0.996	0.000
E22 Hyperfunction of pituitary gland	0.004	0.996	0.000
E20 Hypoparathyroidism	0.004	0.996	0.000
I77.1 Stricture of artery	0.000	0.996	0.004
W25 Contact with sharp glass	0.004	0.996	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.004	0.996	0.000
T78.9 Adverse effect, unspecified	0.003	0.996	0.000
B35.1 Tinea unguium	0.003	0.996	0.000
D75 Other diseases of blood and blood-forming organs	0.004	0.996	0.000
E34 Other endocrine disorders	0.004	0.996	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.003	0.996	0.000
E23.1 Drug-induced hypopituitarism	0.003	0.996	0.000
E13.9 Without complications	0.004	0.996	0.000
E61 Deficiency of other nutrient elements	0.004	0.996	0.000
E23.6 Other disorders of pituitary gland	0.003	0.996	0.000
Y87 Sequelae of intentional self-harm, assault and events of undetermined intent	0.003	0.996	0.000
D59.9 Acquired haemolytic anaemia, unspecified	0.003	0.996	0.000
D59.8 Other acquired haemolytic anaemias	0.003	0.996	0.000
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.003	0.996	0.000
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.003	0.996	0.000
D59.4 Other nonautoimmune haemolytic anaemias	0.003	0.996	0.000
D59.3 Haemolytic-uraemic syndrome	0.003	0.996	0.000
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.003	0.996	0.000
D59.0 Drug-induced autoimmune haemolytic anaemia	0.003	0.996	0.000
S82.81 Fractures of other parts of lower leg (open)	0.003	0.997	0.000
E21.4 Other specified disorders of parathyroid gland	0.003	0.997	0.000
E21.2 Other hyperparathyroidism	0.003	0.997	0.000
D53 Other nutritional anaemias	0.003	0.997	0.000
D82 Immunodeficiency associated with other major defects	0.003	0.997	0.000
D81 Combined immunodeficiencies	0.003	0.997	0.000
E29 Testicular dysfunction	0.003	0.997	0.000
T90.9 Sequelae of unspecified injury of head	0.003	0.997	0.000
E24.8 Other Cushing's syndrome	0.003	0.997	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.003	0.997	0.000
E24.3 Ectopic ACTH syndrome	0.003	0.997	0.000
E24.1 Nelson's syndrome	0.003	0.997	0.000
D83 Common variable immunodeficiency	0.003	0.997	0.000
T78.2 Anaphylactic shock, unspecified	0.003	0.997	0.000
T90.8 Sequelae of other specified injuries of head	0.003	0.997	0.000
E24.2 Drug-induced Cushing's syndrome	0.003	0.997	0.000
V23 Motorcycle rider injured in collision with car, pick-up truck or van	0.003	0.997	0.000
T90.4 Sequelae of injury of eye and orbit	0.003	0.997	0.000
E24.0 Pituitary-dependent Cushing's disease	0.003	0.997	0.000
D84 Other immunodeficiencies	0.003	0.997	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.003	0.997	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.003	0.997	0.000
T90.0 Sequelae of superficial injury of head	0.003	0.997	0.000
D72 Other disorders of white blood cells	0.003	0.997	0.000
D51 Vitamin B12 deficiency anaemia	0.003	0.997	0.000
D80 Immunodeficiency with predominantly antibody defects	0.003	0.997	0.000
Y40 Systemic antibiotics	0.003	0.997	0.000
R25.2 Cramp and spasm	0.000	0.997	0.003
T94 Sequelae of injuries involving multiple and unspecified body regions	0.003	0.997	0.000
E22.1 Hyperprolactinaemia	0.003	0.997	0.000
K56.6 Other and unspecified intestinal obstruction	0.000	0.997	0.003
X41.0 Home	0.003	0.997	0.000
X41.8 Other specified place	0.003	0.997	0.000
X41.7 Farm	0.003	0.997	0.000
X41.6 Industrial and construction area	0.003	0.997	0.000
X41.5 Trade and service area	0.003	0.997	0.000
X41.4 Street and highway	0.003	0.997	0.000
X41.3 Sports and athletics area	0.003	0.997	0.000
X41.2 School, other institution and public administrative area	0.003	0.997	0.000
X41.1 Residential institution	0.003	0.997	0.000
V20-V29 Motorcycle rider injured in transport accident	0.003	0.997	0.000
I77.8 Other specified disorders of arteries and arterioles	0.000	0.997	0.003
V23.4 Driver injured in traffic accident	0.003	0.997	0.000
V23.0 Driver injured in nontraffic accident	0.003	0.997	0.000
X42 Accidental poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified	0.003	0.997	0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.003	0.997	0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.003	0.997	0.000
X47 Accidental poisoning by and exposure to other gases and vapours	0.003	0.997	0.000
Chapter XX External causes of morbidity and mortality	0.003	0.997	0.000
D74.9 Methaemoglobinaemia, unspecified	0.003	0.997	0.000
D74.8 Other methaemoglobinaemias	0.003	0.997	0.000
D74.0 Congenital methaemoglobinaemia	0.003	0.997	0.000
E25.9 Adrenogenital disorder, unspecified	0.003	0.997	0.000
E25.8 Other adrenogenital disorders	0.003	0.997	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.003	0.997	0.000
E30.9 Disorder of puberty, unspecified	0.003	0.997	0.000
E30.8 Other disorders of puberty	0.003	0.997	0.000
E30.1 Precocious puberty	0.003	0.997	0.000
E30.0 Delayed puberty	0.003	0.997	0.000
E31.9 Polyglandular dysfunction, unspecified	0.003	0.997	0.000
E31.8 Other polyglandular dysfunction	0.003	0.997	0.000
E31.1 Polyglandular hyperfunction	0.003	0.997	0.000
E31.0 Autoimmune polyglandular failure	0.003	0.997	0.000
E32.9 Disease of thymus, unspecified	0.003	0.997	0.000
E32.8 Other diseases of thymus	0.003	0.997	0.000
E32.1 Abscess of thymus	0.003	0.997	0.000
E32.0 Persistent hyperplasia of thymus	0.003	0.997	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.003	0.997	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.003	0.997	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.003	0.997	0.000
T90.5 Sequelae of intracranial injury	0.003	0.997	0.000
T91 Sequelae of injuries of neck and trunk	0.003	0.997	0.000
X44 Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances	0.003	0.997	0.000
T78.3 Angioneurotic oedema	0.003	0.997	0.000
S82.60 Fracture of lateral malleolus (closed)	0.003	0.997	0.000
E34.0 Carcinoid syndrome	0.003	0.997	0.000
E80.4 Gilbert's syndrome	0.000	0.997	0.003
T98 Sequelae of other and unspecified effects of external causes	0.003	0.997	0.000
C25.2 Tail of pancreas	0.003	0.997	0.000
Y87.2 Sequelae of events of undetermined intent	0.003	0.997	0.000
D75.1 Secondary polycythaemia	0.003	0.997	0.000
T95 Sequelae of burns, corrosions and frostbite	0.003	0.997	0.000
D75.9 Disease of blood and blood-forming organs, unspecified	0.003	0.997	0.000
M34.9 Systemic sclerosis, unspecified	0.003	0.997	0.000
T90.3 Sequelae of injury of cranial nerves	0.003	0.997	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.003	0.997	0.000
D76.2 Haemophagocytic syndrome, infection-associated	0.003	0.997	0.000
D76.1 Haemophagocytic lymphohistiocytosis	0.003	0.997	0.000
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.003	0.997	0.000
D53.9 Nutritional anaemia, unspecified	0.003	0.997	0.000
D75.2 Essential thrombocytosis	0.003	0.997	0.000
E28.9 Ovarian dysfunction, unspecified	0.003	0.997	0.000
E28.8 Other ovarian dysfunction	0.003	0.997	0.000
E28.1 Androgen excess	0.003	0.997	0.000
E28.0 Oestrogen excess	0.003	0.997	0.000
Y40.7 Antifungal antibiotics, systemically used	0.003	0.997	0.000
Y89.1 Sequelae of war operations	0.003	0.997	0.000
Y89.0 Sequelae of legal intervention	0.003	0.997	0.000
X43 Accidental poisoning by and exposure to other drugs acting on the autonomic nervous system	0.003	0.997	0.000
Y88 Sequelae of surgical and medical care as external cause	0.003	0.997	0.000
E20.8 Other hypoparathyroidism	0.003	0.997	0.000
E20.1 Pseudohypoparathyroidism	0.003	0.997	0.000
E20.0 Idiopathic hypoparathyroidism	0.003	0.997	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.003	0.997	0.000
E22.8 Other hyperfunction of pituitary gland	0.003	0.997	0.000
R40.2 Coma, unspecified	0.000	0.997	0.003
X48 Accidental poisoning by and exposure to pesticides	0.003	0.997	0.000
X46 Accidental poisoning by and exposure to organic solvents and halogenated hydrocarbons and their vapours	0.003	0.997	0.000
X40 Accidental poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics	0.003	0.997	0.000
E23.2 Diabetes insipidus	0.003	0.997	0.000
W25.6 Industrial and construction area	0.003	0.997	0.000
W25.5 Trade and service area	0.003	0.997	0.000
W25.1 Residential institution	0.003	0.997	0.000
W25.0 Home	0.003	0.997	0.000
W25.7 Farm	0.003	0.997	0.000
W25.4 Street and highway	0.003	0.997	0.000
W25.3 Sports and athletics area	0.003	0.997	0.000
W25.2 School, other institution and public administrative area	0.003	0.997	0.000
D86 Sarcoidosis	0.003	0.997	0.000
V20 Motorcycle rider injured in collision with pedestrian or animal	0.003	0.997	0.000
X45 Accidental poisoning by and exposure to alcohol	0.003	0.997	0.000
E28.3 Primary ovarian failure	0.003	0.997	0.000
Y81 General- and plastic-surgery devices associated with adverse incidents	0.003	0.997	0.000
W20-W49 Exposure to inanimate mechanical forces	0.003	0.997	0.000
W25.8 Other specified place	0.003	0.997	0.000
Y40.4 Tetracyclines	0.003	0.997	0.000
E34.5 Androgen resistance syndrome	0.003	0.997	0.000
E34.4 Constitutional tall stature	0.003	0.997	0.000
E34.3 Short stature, not elsewhere classified	0.003	0.997	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations