TreeWAS – Variant ID: rs72666268

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
C44 Other malignant neoplasms of skin	0.000	0.609	0.391
C44.5 Skin of trunk	0.000	0.614	0.386
C44.1 Skin of eyelid, including canthus	0.000	0.615	0.385
C44.7 Skin of lower limb, including hip	0.000	0.619	0.381
C44.4 Skin of scalp and neck	0.000	0.641	0.359
C44.9 Malignant neoplasm of skin, unspecified	0.000	0.659	0.341
C44.0 Skin of lip	0.000	0.713	0.287
C44.8 Overlapping lesion of skin	0.000	0.720	0.280
C44.2 Skin of ear and external auricular canal	0.000	0.731	0.269
C44.3 Skin of other and unspecified parts of face	0.000	0.847	0.153
C44.6 Skin of upper limb, including shoulder	0.000	0.851	0.149
I65.2 Occlusion and stenosis of carotid artery	0.089	0.911	0.000
C43-C44 Melanoma and other malignant neoplasms of skin	0.000	0.915	0.085
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.037	0.963	0.000
I65.3 Occlusion and stenosis of multiple and bilateral precerebral arteries	0.028	0.971	0.000
I65.9 Occlusion and stenosis of unspecified precerebral artery	0.027	0.973	0.000
I65.8 Occlusion and stenosis of other precerebral artery	0.027	0.973	0.000
I65.1 Occlusion and stenosis of basilar artery	0.027	0.973	0.000
I65.0 Occlusion and stenosis of vertebral artery	0.024	0.976	0.000
C43 Malignant melanoma of skin	0.000	0.977	0.023
C43.5 Malignant melanoma of trunk	0.000	0.979	0.021
I34.0 Mitral (valve) insufficiency	0.000	0.979	0.021
C43.2 Malignant melanoma of ear and external auricular canal	0.000	0.983	0.017
C43.8 Overlapping malignant melanoma of skin	0.000	0.983	0.017
C43.1 Malignant melanoma of eyelid, including canthus	0.000	0.983	0.017
C43.0 Malignant melanoma of lip	0.000	0.983	0.017
C43.4 Malignant melanoma of scalp and neck	0.000	0.984	0.016
O73.0 Retained placenta, without haemorrhage	0.016	0.984	0.000
O63.1 Prolonged second stage (of labour)	0.015	0.985	0.000
I34 Nonrheumatic mitral valve disorders	0.000	0.985	0.015
O73 Retained placenta and membranes, without haemorrhage	0.015	0.985	0.000
O63 Long labour	0.014	0.986	0.000
I34.1 Mitral (valve) prolapse	0.000	0.986	0.014
O60-O75 Complications of labour and delivery	0.014	0.986	0.000
C43.6 Malignant melanoma of upper limb, including shoulder	0.000	0.986	0.014
O64 Obstructed labour due to malposition and malpresentation of foetus	0.013	0.987	0.000
C43.9 Malignant melanoma of skin, unspecified	0.000	0.987	0.012
O63.0 Prolonged first stage (of labour)	0.012	0.987	0.000
O66 Other obstructed labour	0.012	0.988	0.000
O64.1 Obstructed labour due to breech presentation	0.012	0.988	0.000
I34.2 Nonrheumatic mitral (valve) stenosis	0.000	0.988	0.012
O71 Other obstetric trauma	0.012	0.988	0.000
O69 Labour and delivery complicated by umbilical cord complications	0.012	0.988	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.011	0.989	0.000
O94-O99 Other obstetric conditions, not elsewhere classified	0.011	0.989	0.000
I34.8 Other nonrheumatic mitral valve disorders	0.000	0.989	0.011
O69.2 Labour and delivery complicated by other cord entanglement	0.011	0.989	0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified	0.011	0.989	0.000
O71.8 Other specified obstetric trauma	0.011	0.989	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.011	0.989	0.000
O20-O29 Other maternal disorders predominantly related to pregnancy	0.011	0.989	0.000
O63.2 Delayed delivery of second twin, triplet, etc.	0.011	0.989	0.000
O65 Obstructed labour due to maternal pelvic abnormality	0.010	0.989	0.000
O99.2 Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium	0.011	0.989	0.000
O74 Complications of anaesthesia during labour and delivery	0.010	0.989	0.000
O60 Preterm delivery	0.010	0.989	0.000
O70 Perineal laceration during delivery	0.010	0.990	0.000
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium	0.010	0.990	0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified	0.000	0.990	0.010
O73.1 Retained portions of placenta and membranes, without haemorrhage	0.010	0.990	0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium	0.010	0.990	0.000
O85-O92 Complications predominantly related to the puerperium	0.010	0.990	0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium	0.010	0.990	0.000
O26 Maternal care for other conditions predominantly related to pregnancy	0.010	0.990	0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.010	0.990	0.000
O64.8 Obstructed labour due to other malposition and malpresentation	0.010	0.990	0.000
O70.1 Second degree perineal laceration during delivery	0.010	0.990	0.000
O64.9 Obstructed labour due to malposition and malpresentation, unspecified	0.009	0.990	0.000
O64.5 Obstructed labour due to compound presentation	0.009	0.990	0.000
O64.4 Obstructed labour due to shoulder presentation	0.009	0.990	0.000
O64.3 Obstructed labour due to brow presentation	0.009	0.990	0.000
O64.2 Obstructed labour due to face presentation	0.009	0.990	0.000
O26.9 Pregnancy-related condition, unspecified	0.009	0.991	0.000
O66.0 Obstructed labour due to shoulder dystocia	0.009	0.991	0.000
O66.9 Obstructed labour, unspecified	0.009	0.991	0.000
O66.8 Other specified obstructed labour	0.009	0.991	0.000
O66.4 Failed trial of labour, unspecified	0.009	0.991	0.000
O66.3 Obstructed labour due to other abnormalities of foetus	0.009	0.991	0.000
O66.2 Obstructed labour due to unusually large foetus	0.009	0.991	0.000
O66.1 Obstructed labour due to locked twins	0.009	0.991	0.000
O70.9 Perineal laceration during delivery, unspecified	0.009	0.991	0.000
O72 Postpartum haemorrhage	0.009	0.991	0.000
O22 Venous complications in pregnancy	0.009	0.991	0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified	0.009	0.991	0.000
O24 Diabetes mellitus in pregnancy	0.009	0.991	0.000
O61 Failed induction of labour	0.009	0.991	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.009	0.991	0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head	0.009	0.991	0.000
O71.9 Obstetric trauma, unspecified	0.009	0.991	0.000
O71.6 Obstetric damage to pelvic joints and ligaments	0.009	0.991	0.000
O71.5 Other obstetric injury to pelvic organs	0.009	0.991	0.000
O71.3 Obstetric laceration of cervix	0.009	0.991	0.000
O71.2 Postpartum inversion of uterus	0.009	0.991	0.000
O71.1 Rupture of uterus during labour	0.009	0.991	0.000
O71.0 Rupture of uterus before onset of labour	0.009	0.991	0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.009	0.991	0.000
O69.0 Labour and delivery complicated by prolapse of cord	0.009	0.991	0.000
O90 Complications of the puerperium, not elsewhere classified	0.009	0.991	0.000
O69.5 Labour and delivery complicated by vascular lesion of cord	0.008	0.991	0.000
O69.4 Labour and delivery complicated by vasa praevia	0.008	0.991	0.000
O69.3 Labour and delivery complicated by short cord	0.008	0.991	0.000
O71.7 Obstetric haematoma of pelvis	0.008	0.991	0.000
O99.7 Diseases of the skin and subcutaneous tissue complicating pregnancy, childbirth and the puerperium	0.008	0.991	0.000
O20 Haemorrhage in early pregnancy	0.008	0.992	0.000
O69.9 Labour and delivery complicated by cord complication, unspecified	0.008	0.992	0.000
O68.9 Labour and delivery complicated by foetal stress, unspecified	0.008	0.992	0.000
O21 Excessive vomiting in pregnancy	0.008	0.992	0.000
O97 Death from sequelae of direct obstetric causes	0.008	0.992	0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.008	0.992	0.000
O95 Obstetric death of unspecified cause	0.008	0.992	0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.008	0.992	0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium	0.008	0.992	0.000
O29 Complications of anaesthesia during pregnancy	0.008	0.992	0.000
O25 Malnutrition in pregnancy	0.008	0.992	0.000
O24.4 Diabetes mellitus arising in pregnancy	0.008	0.992	0.000
O80-O84 Delivery	0.008	0.992	0.000
O68 Labour and delivery complicated by foetal stress [distress]	0.008	0.992	0.000
C43.3 Malignant melanoma of other and unspecified parts of face	0.001	0.992	0.007
O65.5 Obstructed labour due to abnormality of maternal pelvic organs	0.008	0.992	0.000
O87 Venous complications in the puerperium	0.008	0.992	0.000
O89 Complications of anaesthesia during the puerperium	0.008	0.992	0.000
O65.9 Obstructed labour due to maternal pelvic abnormality, unspecified	0.008	0.992	0.000
O65.8 Obstructed labour due to other maternal pelvic abnormalities	0.008	0.992	0.000
O65.4 Obstructed labour due to foetopelvic disproportion, unspecified	0.008	0.992	0.000
O65.3 Obstructed labour due to pelvic outlet and midcavity contraction	0.008	0.992	0.000
O65.2 Obstructed labour due to pelvic inlet contraction	0.008	0.992	0.000
O65.1 Obstructed labour due to generally contracted pelvis	0.008	0.992	0.000
O65.0 Obstructed labour due to deformed pelvis	0.008	0.992	0.000
O99.4 Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium	0.008	0.992	0.000
O85 Puerperal sepsis	0.008	0.992	0.000
O60.3 Preterm delivery without spontaneous labour	0.008	0.992	0.000
O60.2 Preterm spontaneous labour with term delivery	0.008	0.992	0.000
O60.1 Preterm spontaneous labour with preterm delivery	0.008	0.992	0.000
O60.0 Preterm labour without delivery	0.008	0.992	0.000
O74.9 Complication of anaesthesia during labour and delivery, unspecified	0.008	0.992	0.000
O74.8 Other complications of anaesthesia during labour and delivery	0.008	0.992	0.000
O74.7 Failed or difficult intubation during labour and delivery	0.008	0.992	0.000
O74.6 Other complications of spinal and epidural anaesthesia during labour and delivery	0.008	0.992	0.000
O74.5 Spinal and epidural anaesthesia-induced headache during labour and delivery	0.008	0.992	0.000
O74.4 Toxic reaction to local anaesthesia during labour and delivery	0.008	0.992	0.000
O74.3 Central nervous system complications of anaesthesia during labour and delivery	0.008	0.992	0.000
O74.2 Cardiac complications of anaesthesia during labour and delivery	0.008	0.992	0.000
O74.1 Other pulmonary complications of anaesthesia during labour and delivery	0.008	0.992	0.000
O74.0 Aspiration pneumonitis due to anaesthesia during labour and delivery	0.008	0.992	0.000
O70.3 Fourth degree perineal laceration during delivery	0.008	0.992	0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.008	0.992	0.000
O26.2 Pregnancy care of habitual aborter	0.008	0.992	0.000
O28 Abnormal findings on antenatal screening of mother	0.008	0.992	0.000
O20.8 Other haemorrhage in early pregnancy	0.008	0.992	0.000
O72.2 Delayed and secondary postpartum haemorrhage	0.008	0.992	0.000
O26.6 Liver disorders in pregnancy, childbirth and the puerperium	0.007	0.992	0.000
O23 Infections of genito-urinary tract in pregnancy	0.007	0.993	0.000
O69.8 Labour and delivery complicated by other cord complications	0.007	0.993	0.000
O91 Infections of breast associated with childbirth	0.007	0.993	0.000
O88 Obstetric embolism	0.007	0.993	0.000
O71.4 Obstetric high vaginal laceration alone	0.007	0.993	0.000
O75.8 Other specified complications of labour and delivery	0.007	0.993	0.000
O26.5 Maternal hypotension syndrome	0.007	0.993	0.000
O26.4 Herpes gestationis	0.007	0.993	0.000
O26.3 Retained intra-uterine contraceptive device in pregnancy	0.007	0.993	0.000
O26.1 Low weight gain in pregnancy	0.007	0.993	0.000
O26.0 Excessive weight gain in pregnancy	0.007	0.993	0.000
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium	0.007	0.993	0.000
O22.0 Varicose veins of lower extremity in pregnancy	0.007	0.993	0.000
O22.4 Haemorrhoids in pregnancy	0.007	0.993	0.000
O92 Other disorders of breast and lactation associated with childbirth	0.007	0.993	0.000
O75.2 Pyrexia during labour, not elsewhere classified	0.007	0.993	0.000
O90.0 Disruption of Caesarean section wound	0.007	0.993	0.000
K04.7 Periapical abscess without sinus	0.007	0.993	0.000
O86 Other puerperal infections	0.007	0.993	0.000
O98.8 Other maternal infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium	0.007	0.993	0.000
O12 Gestational [pregnancy-induced] oedema and proteinuria without hypertension	0.007	0.993	0.000
O72.0 Third-stage haemorrhage	0.007	0.993	0.000
O90.8 Other complications of the puerperium, not elsewhere classified	0.007	0.993	0.000
O21.0 Mild hyperemesis gravidarum	0.007	0.993	0.000
O81 Single delivery by forceps and vacuum extractor	0.007	0.993	0.000
O24.9 Diabetes mellitus in pregnancy, unspecified	0.007	0.993	0.000
O72.3 Postpartum coagulation defects	0.007	0.993	0.000
O22.9 Venous complication in pregnancy, unspecified	0.007	0.993	0.000
O22.8 Other venous complications in pregnancy	0.007	0.993	0.000
O22.5 Cerebral venous thrombosis in pregnancy	0.007	0.993	0.000
O22.3 Deep phlebothrombosis in pregnancy	0.007	0.993	0.000
O22.2 Superficial thrombophlebitis in pregnancy	0.007	0.993	0.000
O22.1 Genital varices in pregnancy	0.007	0.993	0.000
O24.3 Pre-existing diabetes mellitus, unspecified	0.007	0.993	0.000
O24.2 Pre-existing malnutrition-related diabetes mellitus	0.007	0.993	0.000
O24.1 Pre-existing diabetes mellitus, noninsulin-dependent	0.007	0.993	0.000
O67.8 Other intrapartum haemorrhage	0.006	0.993	0.000
O67.0 Intrapartum haemorrhage with coagulation defect	0.006	0.993	0.000
O90.1 Disruption of perineal obstetric wound	0.007	0.993	0.000
O61.9 Failed induction of labour, unspecified	0.006	0.993	0.000
O61.8 Other failed induction of labour	0.006	0.993	0.000
O61.1 Failed instrumental induction of labour	0.006	0.993	0.000
O69.1 Labour and delivery complicated by cord around neck, with compression	0.007	0.993	0.000
O75.9 Complication of labour and delivery, unspecified	0.006	0.993	0.000
O75.5 Delayed delivery after artificial rupture of membranes	0.006	0.993	0.000
O75.4 Other complications of obstetric surgery and procedures	0.006	0.993	0.000
O75.3 Other infection during labour	0.006	0.993	0.000
O75.1 Shock during or following labour and delivery	0.006	0.993	0.000
O63.9 Long labour, unspecified	0.006	0.993	0.000
O98.9 Unspecified maternal infectious or parasitic disease complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.7 Human immunodeficiency [HIV] disease complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.6 Protozoal diseases complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.5 Other viral diseases complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.4 Viral hepatitis complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.3 Other infections with a predominantly sexual mode of transmission complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.2 Gonorrhoea complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.1 Syphilis complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O98.0 Tuberculosis complicating pregnancy, childbirth and the puerperium	0.006	0.993	0.000
O70.2 Third degree perineal laceration during delivery	0.006	0.993	0.000
O87.2 Haemorrhoids in the puerperium	0.006	0.993	0.000
O90.9 Complication of the puerperium, unspecified	0.006	0.993	0.000
O90.5 Postpartum thyroiditis	0.006	0.993	0.000
O90.4 Postpartum acute renal failure	0.006	0.993	0.000
O90.3 Cardiomyopathy in the puerperium	0.006	0.993	0.000
O90.2 Haematoma of obstetric wound	0.006	0.993	0.000
O89.4 Spinal and epidural anaesthesia-induced headache during the puerperium	0.006	0.994	0.000
O21.1 Hyperemesis gravidarum with metabolic disturbance	0.006	0.994	0.000
O20.9 Haemorrhage in early pregnancy, unspecified	0.006	0.994	0.000
O21.8 Other vomiting complicating pregnancy	0.006	0.994	0.000
O21.2 Late vomiting of pregnancy	0.006	0.994	0.000
O96.9 Death from unspecified obstetric cause	0.006	0.994	0.000
O96.1 Death from indirect obstetric cause	0.006	0.994	0.000
O96.0 Death from direct obstetric cause	0.006	0.994	0.000
O97.9 Death from sequelae of obstetric cause, unspecified	0.006	0.994	0.000
O97.1 Death from sequelae of indirect obstetric cause	0.006	0.994	0.000
O97.0 Death from sequelae of direct obstetric cause	0.006	0.994	0.000
O23.9 Other and unspecified genito-urinary tract infection in pregnancy	0.006	0.994	0.000
O12.1 Gestational proteinuria	0.006	0.994	0.000
O29.9 Complication of anaesthesia during pregnancy, unspecified	0.006	0.994	0.000
O29.8 Other complications of anaesthesia during pregnancy	0.006	0.994	0.000
O29.6 Failed or difficult intubation during pregnancy	0.006	0.994	0.000
O29.5 Other complications of spinal and epidural anaesthesia during pregnancy	0.006	0.994	0.000
O29.4 Spinal and epidural anaesthesia-induced headache during pregnancy	0.006	0.994	0.000
O29.3 Toxic reaction to local anaesthesia during pregnancy	0.006	0.994	0.000
O29.2 Central nervous system complications of anaesthesia during pregnancy	0.006	0.994	0.000
O29.1 Cardiac complications of anaesthesia during pregnancy	0.006	0.994	0.000
O29.0 Pulmonary complications of anaesthesia during pregnancy	0.006	0.994	0.000
O12.0 Gestational oedema	0.006	0.994	0.000
O82 Single delivery by Caesarean section	0.006	0.994	0.000
O84 Multiple delivery	0.006	0.994	0.000
O83 Other assisted single delivery	0.006	0.994	0.000
O68.3 Labour and delivery complicated by biochemical evidence of foetal stress	0.006	0.994	0.000
O24.0 Pre-existing diabetes mellitus, insulin-dependent	0.006	0.994	0.000
O87.9 Venous complication in the puerperium, unspecified	0.006	0.994	0.000
O87.8 Other venous complications in the puerperium	0.006	0.994	0.000
O87.3 Cerebral venous thrombosis in the puerperium	0.006	0.994	0.000
O87.1 Deep phlebothrombosis in the puerperium	0.006	0.994	0.000
O87.0 Superficial thrombophlebitis in the puerperium	0.006	0.994	0.000
O89.9 Complication of anaesthesia during the puerperium, unspecified	0.006	0.994	0.000
O89.8 Other complications of anaesthesia during the puerperium	0.006	0.994	0.000
O89.6 Failed or difficult intubation during the puerperium	0.006	0.994	0.000
O89.5 Other complications of spinal and epidural anaesthesia during the puerperium	0.006	0.994	0.000
O89.3 Toxic reaction to local anaesthesia during the puerperium	0.006	0.994	0.000
O89.2 Central nervous system complications of anaesthesia during the puerperium	0.006	0.994	0.000
O89.1 Cardiac complications of anaesthesia during the puerperium	0.006	0.994	0.000
O89.0 Pulmonary complications of anaesthesia during the puerperium	0.006	0.994	0.000
O81.0 Low forceps delivery	0.006	0.994	0.000
O15 Eclampsia	0.006	0.994	0.000
O11 Pre-existing hypertensive disorder with superimposed proteinuria	0.006	0.994	0.000
O28.9 Abnormal finding on antenatal screening of mother, unspecified	0.006	0.994	0.000
O28.8 Other abnormal findings on antenatal screening of mother	0.006	0.994	0.000
O28.5 Abnormal chromosomal and genetic finding on antenatal screening of mother	0.006	0.994	0.000
O28.4 Abnormal radiological finding on antenatal screening of mother	0.006	0.994	0.000
O28.3 Abnormal ultrasonic finding on antenatal screening of mother	0.006	0.994	0.000
O28.2 Abnormal cytological finding on antenatal screening of mother	0.006	0.994	0.000
O28.0 Abnormal haematological finding on antenatal screening of mother	0.006	0.994	0.000
O68.8 Labour and delivery complicated by other evidence of foetal stress	0.006	0.994	0.000
O62 Abnormalities of forces of labour	0.006	0.994	0.000
O92.1 Cracked nipple associated with childbirth	0.006	0.994	0.000
O75.0 Maternal distress during labour and delivery	0.006	0.994	0.000
O23.3 Infections of other parts of urinary tract in pregnancy	0.005	0.994	0.000
O23.2 Infections of urethra in pregnancy	0.005	0.994	0.000
O23.1 Infections of bladder in pregnancy	0.005	0.994	0.000
O23.0 Infections of kidney in pregnancy	0.005	0.994	0.000
I60.9 Subarachnoid haemorrhage, unspecified	0.000	0.994	0.006
O88.8 Other obstetric embolism	0.005	0.994	0.000
O88.3 Obstetric pyaemic and septic embolism	0.005	0.994	0.000
O88.2 Obstetric blood-clot embolism	0.005	0.994	0.000
O88.1 Amniotic fluid embolism	0.005	0.994	0.000
O88.0 Obstetric air embolism	0.005	0.994	0.000
O91.2 Nonpurulent mastitis associated with childbirth	0.005	0.994	0.000
O91.1 Abscess of breast associated with childbirth	0.005	0.994	0.000
O91.0 Infection of nipple associated with childbirth	0.005	0.994	0.000
O92.7 Other and unspecified disorders of lactation	0.005	0.994	0.000
O92.6 Galactorrhoea	0.005	0.994	0.000
O92.5 Suppressed lactation	0.005	0.994	0.000
O92.4 Hypogalactia	0.005	0.994	0.000
O92.3 Agalactia	0.005	0.994	0.000
O92.0 Retracted nipple associated with childbirth	0.005	0.994	0.000
O75.7 Vaginal delivery following previous Caesarean section	0.005	0.994	0.000
O81.4 Vacuum extractor delivery	0.005	0.995	0.000
O28.1 Abnormal biochemical finding on antenatal screening of mother	0.005	0.995	0.000
O21.9 Vomiting of pregnancy, unspecified	0.005	0.995	0.000
O16 Unspecified maternal hypertension	0.005	0.995	0.000
O86.8 Other specified puerperal infections	0.005	0.995	0.000
O86.3 Other genito-urinary tract infections following delivery	0.005	0.995	0.000
O86.2 Urinary tract infection following delivery	0.005	0.995	0.000
O86.1 Other infection of genital tract following delivery	0.005	0.995	0.000
H35.8 Other specified retinal disorders	0.000	0.995	0.005
O12.2 Gestational oedema with proteinuria	0.005	0.995	0.000
O86.4 Pyrexia of unknown origin following delivery	0.005	0.995	0.000
Z73.9 Problem related to life-management difficulty, unspecified	0.005	0.995	0.000
O10 Pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.005	0.995	0.000
S92.00 Fracture of calcaneus (closed)	0.005	0.995	0.000
Z86.1 Personal history of infectious and parasitic diseases	0.005	0.995	0.000
O67.9 Intrapartum haemorrhage, unspecified	0.005	0.995	0.000
O81.5 Delivery by combination of forceps and vacuum extractor	0.005	0.995	0.000
O81.3 Other and unspecified forceps delivery	0.005	0.995	0.000
O81.2 Mid-cavity forceps with rotation	0.005	0.995	0.000
O81.1 Mid-cavity forceps delivery	0.005	0.995	0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.005	0.995	0.000
O23.4 Unspecified infection of urinary tract in pregnancy	0.005	0.995	0.000
O92.2 Other and unspecified disorders of breast associated with childbirth	0.005	0.995	0.000
O61.0 Failed medical induction of labour	0.005	0.995	0.000
K04 Diseases of pulp and periapical tissues	0.005	0.995	0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria	0.005	0.995	0.000
O26.8 Other specified pregnancy-related conditions	0.005	0.995	0.000
O82.9 Delivery by Caesarean section, unspecified	0.005	0.995	0.000
S42.10 Fracture of scapula (closed)	0.005	0.995	0.000
O86.0 Infection of obstetric surgical wound	0.005	0.995	0.000
S92.0 Fracture of calcaneus	0.005	0.995	0.000
O23.5 Infections of the genital tract in pregnancy	0.005	0.995	0.000
S92 Fracture of foot, except ankle	0.005	0.995	0.000
H35.4 Peripheral retinal degeneration	0.000	0.995	0.005
O20.0 Threatened abortion	0.005	0.995	0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.004	0.995	0.000
M25.57 Pain in joint (Ankle and foot)	0.005	0.995	0.000
O82.8 Other single delivery by Caesarean section	0.004	0.995	0.000
O82.2 Delivery by Caesarean hysterectomy	0.004	0.995	0.000
O83.9 Assisted single delivery, unspecified	0.004	0.995	0.000
O83.8 Other specified assisted single delivery	0.004	0.995	0.000
O83.4 Destructive operation for delivery	0.004	0.995	0.000
O83.3 Delivery of viable foetus in abdominal pregnancy	0.004	0.995	0.000
O83.2 Other manipulation-assisted delivery	0.004	0.995	0.000
O83.1 Other assisted breech delivery	0.004	0.995	0.000
O83.0 Breech extraction	0.004	0.995	0.000
O84.9 Multiple delivery, unspecified	0.004	0.995	0.000
O84.8 Other multiple delivery	0.004	0.995	0.000
O84.2 Multiple delivery, all by Caesarean section	0.004	0.995	0.000
O84.1 Multiple delivery, all by forceps and vacuum extractor	0.004	0.995	0.000
O84.0 Multiple delivery, all spontaneous	0.004	0.995	0.000
C43.7 Malignant melanoma of lower limb, including hip	0.000	0.995	0.004
S92.7 Multiple fractures of foot	0.004	0.995	0.000
O82.1 Delivery by emergency Caesarean section	0.004	0.995	0.000
H35 Other retinal disorders	0.000	0.995	0.005
S92.70 Multiple fractures of foot (closed)	0.004	0.996	0.000
O15.9 Eclampsia, unspecified as to time period	0.004	0.996	0.000
O15.2 Eclampsia in the puerperium	0.004	0.996	0.000
O15.1 Eclampsia in labour	0.004	0.996	0.000
O15.0 Eclampsia in pregnancy	0.004	0.996	0.000
O68.0 Labour and delivery complicated by foetal heart rate anomaly	0.004	0.996	0.000
K04.5 Chronic apical periodontitis	0.004	0.996	0.000
K85.9 Acute pancreatitis, unspecified	0.000	0.996	0.004
O62.9 Abnormality of forces of labour, unspecified	0.004	0.996	0.000
O62.8 Other abnormalities of forces of labour	0.004	0.996	0.000
K04.9 Other and unspecified diseases of pulp and periapical tissues	0.004	0.996	0.000
K04.8 Radicular cyst	0.004	0.996	0.000
S92.5 Fracture of other toe	0.004	0.996	0.000
O80 Single spontaneous delivery	0.004	0.996	0.000
H35.0 Background retinopathy and retinal vascular changes	0.000	0.996	0.004
O82.0 Delivery by elective Caesarean section	0.004	0.996	0.000
O62.1 Secondary uterine inertia	0.004	0.996	0.000
O10.9 Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium	0.004	0.996	0.000
O10.4 Pre-existing secondary hypertension complicating pregnancy, childbirth and the puerperium	0.004	0.996	0.000
O10.3 Pre-existing hypertensive heart and renal disease complicating pregnancy, childbirth and the puerperium	0.004	0.996	0.000
O10.2 Pre-existing hypertensive renal disease complicating pregnancy, childbirth and the puerperium	0.004	0.996	0.000
O10.1 Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium	0.004	0.996	0.000
Z75.1 Person awaiting admission to adequate facility elsewhere	0.004	0.996	0.000
O62.4 Hypertonic, incoordinate and prolonged uterine contractions	0.004	0.996	0.000
O62.2 Other uterine inertia	0.004	0.996	0.000
S92.50 Fracture of other toe (closed)	0.004	0.996	0.000
K04.3 Abnormal hard tissue formation in pulp	0.004	0.996	0.000
K04.2 Pulp degeneration	0.004	0.996	0.000
K04.1 Necrosis of pulp	0.004	0.996	0.000
O14.2 HELLP syndrome	0.004	0.996	0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract	0.000	0.996	0.004
H35.6 Retinal haemorrhage	0.000	0.996	0.004
O62.3 Precipitate labour	0.004	0.996	0.000
S92.01 Fracture of calcaneus (open)	0.004	0.996	0.000
K04.4 Acute apical periodontitis of pulpal origin	0.004	0.996	0.000
O14.1 Severe preeclampsia	0.004	0.996	0.000
S92.4 Fracture of great toe	0.004	0.996	0.000
S92.2 Fracture of other tarsal bone(s)	0.004	0.996	0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery	0.000	0.996	0.004
S92.9 Fracture of foot, unspecified	0.004	0.996	0.000
S92.1 Fracture of talus	0.004	0.996	0.000
Z30.5 Surveillance of (intra-uterine) contraceptive device	0.000	0.996	0.004
H35.2 Other proliferative retinopathy	0.000	0.996	0.004
H35.7 Separation of retinal layers	0.000	0.996	0.004
V18.0 Driver injured in nontraffic accident	0.004	0.996	0.000
H35.9 Retinal disorder, unspecified	0.000	0.996	0.004
O10.0 Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium	0.003	0.996	0.000
O14.0 Moderate preeclampsia	0.003	0.996	0.000
I60 Subarachnoid haemorrhage	0.000	0.996	0.004
S92.71 Multiple fractures of foot (open)	0.003	0.996	0.000
S92.51 Fracture of other toe (open)	0.003	0.996	0.000
H35.1 Retinopathy of prematurity	0.000	0.996	0.003
S92.3 Fracture of metatarsal bone	0.003	0.997	0.000
O00-O08 Pregnancy with abortive outcome	0.003	0.997	0.000
O14.9 Preeclampsia, unspecified	0.003	0.997	0.000
S90-S99 Injuries to the ankle and foot	0.003	0.997	0.000
K01.1 Impacted teeth	0.003	0.997	0.000
Y57.9 Drug or medicament, unspecified	0.003	0.997	0.000
O80.1 Spontaneous breech delivery	0.003	0.997	0.000
R47.0 Dysphasia and aphasia	0.000	0.997	0.003
O62.0 Primary inadequate contractions	0.003	0.997	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.003	0.997	0.000
K01 Embedded and impacted teeth	0.003	0.997	0.000
K04.0 Pulpitis	0.003	0.997	0.000
O80.8 Other single spontaneous delivery	0.003	0.997	0.000
K14.8 Other diseases of tongue	0.003	0.997	0.000
O80.9 Single spontaneous delivery, unspecified	0.003	0.997	0.000
Y45.0 Opioids and related analgesics	0.003	0.997	0.000
S92.40 Fracture of great toe (closed)	0.003	0.997	0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws	0.003	0.997	0.000
S96 Injury of muscle and tendon at ankle and foot level	0.003	0.997	0.000
K05.1 Chronic gingivitis	0.003	0.997	0.000
S93.0 Dislocation of ankle joint	0.003	0.997	0.000
K05 Gingivitis and periodontal diseases	0.003	0.997	0.000
S92.20 Fracture of other tarsal bone(s) (closed)	0.003	0.997	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.003	0.997	0.000
S43.0 Dislocation of shoulder joint	0.000	0.997	0.003
S92.21 Fracture of other tarsal bone(s) (open)	0.003	0.997	0.000
S92.91 Fracture of foot, unspecified (open)	0.003	0.997	0.000
S92.90 Fracture of foot, unspecified (closed)	0.003	0.997	0.000
K11.6 Mucocele of salivary gland	0.003	0.997	0.000
K12 Stomatitis and related lesions	0.003	0.997	0.000
S92.11 Fracture of talus (open)	0.003	0.997	0.000
F52.2 Failure of genital response	0.000	0.997	0.003
K11 Diseases of salivary glands	0.003	0.997	0.000
S92.41 Fracture of great toe (open)	0.003	0.997	0.000
H35.5 Hereditary retinal dystrophy	0.000	0.997	0.003
S97 Crushing injury of ankle and foot	0.003	0.997	0.000
S92.10 Fracture of talus (closed)	0.003	0.997	0.000
I60.8 Other subarachnoid haemorrhage	0.000	0.997	0.003
K05.0 Acute gingivitis	0.003	0.997	0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid	0.003	0.997	0.000
R72 Abnormality of white blood cells, not elsewhere classified	0.003	0.997	0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified	0.000	0.997	0.003
I60.6 Subarachnoid haemorrhage from other intracranial arteries	0.000	0.997	0.003
I60.5 Subarachnoid haemorrhage from vertebral artery	0.000	0.997	0.003
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation	0.000	0.997	0.003
I73.9 Peripheral vascular disease, unspecified	0.000	0.997	0.003
K04.6 Periapical abscess with sinus	0.003	0.997	0.000
S93.3 Dislocation of other and unspecified parts of foot	0.003	0.997	0.000
S91 Open wound of ankle and foot	0.003	0.997	0.000
I60.4 Subarachnoid haemorrhage from basilar artery	0.000	0.997	0.003
S42.1 Fracture of scapula	0.003	0.997	0.000
K05.5 Other periodontal diseases	0.003	0.997	0.000
O72.1 Other immediate postpartum haemorrhage	0.003	0.997	0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery	0.000	0.997	0.003
S92.31 Fracture of metatarsal bone (open)	0.003	0.997	0.000
S91.1 Open wound of toe(s) without damage to nail	0.003	0.997	0.000
O08 Complications following abortion and ectopic and molar pregnancy	0.003	0.997	0.000
O07 Failed attempted abortion	0.003	0.997	0.000
O06 Unspecified abortion	0.003	0.997	0.000
O05 Other abortion	0.003	0.997	0.000
O01 Hydatidiform mole	0.003	0.997	0.000
K11.1 Hypertrophy of salivary gland	0.003	0.997	0.000
Y57 Other and unspecified drugs and medicaments	0.003	0.997	0.000
S98 Traumatic amputation of ankle and foot	0.003	0.997	0.000
S95 Injury of blood vessels at ankle and foot level	0.003	0.997	0.000
S94 Injury of nerves at ankle and foot level	0.003	0.997	0.000
H36.0 Diabetic retinopathy	0.000	0.997	0.003
S96.1 Injury of muscle and tendon of long extensor muscle of toe at ankle and foot level	0.003	0.997	0.000
K03 Other diseases of hard tissues of teeth	0.003	0.997	0.000
O04 Medical abortion	0.003	0.997	0.000
K01.0 Embedded teeth	0.003	0.997	0.000
K12.0 Recurrent oral aphthae	0.003	0.997	0.000
S99 Other and unspecified injuries of ankle and foot	0.003	0.997	0.000
S96.9 Injury of unspecified muscle and tendon at ankle and foot level	0.003	0.997	0.000
K12.3 Oral mucositis (ulcerative)	0.003	0.997	0.000
S93.4 Sprain and strain of ankle	0.002	0.997	0.000
S93.6 Sprain and strain of other and unspecified parts of foot	0.002	0.997	0.000
S93.5 Sprain and strain of toe(s)	0.002	0.997	0.000
S93.2 Rupture of ligaments at ankle and foot level	0.002	0.997	0.000
S02.60 Fracture of mandible (closed)	0.003	0.997	0.000
S93.1 Dislocation of toe(s)	0.003	0.997	0.000
K14 Diseases of tongue	0.003	0.997	0.000
K11.7 Disturbances of salivary secretion	0.003	0.997	0.000
M43.16 Spondylolisthesis (Lumbar region)	0.003	0.997	0.000
O47.1 False labour at or after 37 completed weeks of gestation	0.003	0.997	0.000
S97.8 Crushing injury of other parts of ankle and foot	0.002	0.997	0.000
K61.0 Anal abscess	0.003	0.997	0.000
Z75 Problems related to medical facilities and other health care	0.003	0.997	0.000
K11.9 Disease of salivary gland, unspecified	0.002	0.997	0.000
S96.8 Injury of other muscles and tendons at ankle and foot level	0.002	0.997	0.000
S96.7 Injury of multiple muscles and tendons at ankle and foot level	0.002	0.997	0.000
S96.2 Injury of intrinsic muscle and tendon at ankle and foot level	0.002	0.997	0.000
S96.0 Injury of muscle and tendon of long flexor muscle of toe at ankle and foot level	0.002	0.997	0.000
K12.1 Other forms of stomatitis	0.002	0.998	0.000
Y57.5 X-ray contrast media	0.002	0.998	0.000
S92.30 Fracture of metatarsal bone (closed)	0.002	0.998	0.000
K05.2 Acute periodontitis	0.002	0.998	0.000
K05.4 Periodontosis	0.002	0.998	0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery	0.000	0.998	0.002
M43.1 Spondylolisthesis	0.002	0.998	0.000
R26.3 Immobility	0.002	0.998	0.000
K11.3 Abscess of salivary gland	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations