TreeWAS – Variant ID: rs76894896

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
C44 Other malignant neoplasms of skin	1.000	0.000
C44.3 Skin of other and unspecified parts of face	1.000	0.000
C43-C44 Melanoma and other malignant neoplasms of skin	0.991	0.009
C44.6 Skin of upper limb, including shoulder	0.989	0.011
C43 Malignant melanoma of skin	0.989	0.011
C44.4 Skin of scalp and neck	0.986	0.014
C43.6 Malignant melanoma of upper limb, including shoulder	0.968	0.032
C43.5 Malignant melanoma of trunk	0.948	0.052
C44.5 Skin of trunk	0.906	0.094
C44.1 Skin of eyelid, including canthus	0.902	0.098
C43.4 Malignant melanoma of scalp and neck	0.891	0.109
C43.3 Malignant melanoma of other and unspecified parts of face	0.839	0.161
C44.2 Skin of ear and external auricular canal	0.803	0.197
C44.7 Skin of lower limb, including hip	0.783	0.217
C43.1 Malignant melanoma of eyelid, including canthus	0.777	0.223
C43.9 Malignant melanoma of skin, unspecified	0.720	0.280
C44.8 Overlapping lesion of skin	0.717	0.283
C43.8 Overlapping malignant melanoma of skin	0.709	0.291
C43.0 Malignant melanoma of lip	0.709	0.291
C44.9 Malignant neoplasm of skin, unspecified	0.672	0.327
C43.2 Malignant melanoma of ear and external auricular canal	0.665	0.335
C44.0 Skin of lip	0.540	0.459
C43.7 Malignant melanoma of lower limb, including hip	0.242	0.758
L57.0 Actinic keratosis	0.069	0.931
L57 Skin changes due to chronic exposure to nonionising radiation	0.056	0.944
M20-M25 Other joint disorders	0.050	0.950
L57.8 Other skin changes due to chronic exposure to nonionising radiation	0.050	0.950
M34 Systemic sclerosis	0.050	0.950
M24 Other specific joint derangements	0.049	0.951
M20 Acquired deformities of fingers and toes	0.048	0.952
M20.1 Hallux valgus (acquired)	0.048	0.952
M20.6 Acquired deformity of toe(s), unspecified	0.047	0.953
M21 Other acquired deformities of limbs	0.047	0.953
L57.9 Skin changes due to chronic exposure to nonionising radiation, unspecified	0.047	0.953
M34.9 Systemic sclerosis, unspecified	0.045	0.955
M34.1 CR(E)ST syndrome	0.044	0.956
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.044	0.956
M24.4 Recurrent dislocation and subluxation of joint	0.043	0.957
M24.8 Other specific joint derangements, not elsewhere classified	0.043	0.957
M21.3 Wrist or foot drop (acquired)	0.042	0.958
M34.8 Other forms of systemic sclerosis	0.042	0.958
M22 Disorders of patella	0.042	0.958
M30 Polyarteritis nodosa and related conditions	0.041	0.958
M32 Systemic lupus erythematosus	0.041	0.959
L57.5 Actinic granuloma	0.040	0.959
L57.3 Poikiloderma of Civatte	0.040	0.959
L57.2 Cutis rhomboidalis nuchae	0.040	0.959
L57.1 Actinic reticuloid	0.040	0.959
M24.37 Pathological dislocation and subluxation of joint, not elsewhere classified (Ankle and foot)	0.040	0.960
M21.6 Other acquired deformities of ankle and foot	0.040	0.960
M21.4 Flat foot [pes planus] (acquired)	0.039	0.961
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.039	0.961
M21.8 Other specified acquired deformities of limbs	0.038	0.962
L57.4 Cutis laxa senilis	0.038	0.962
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.036	0.964
M22.0 Recurrent dislocation of patella	0.036	0.964
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.036	0.964
M24.6 Ankylosis of joint	0.036	0.964
M34.2 Systemic sclerosis induced by drugs and chemicals	0.036	0.964
M34.0 Progressive systemic sclerosis	0.036	0.964
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)	0.036	0.964
M33 Dermatopolymyositis	0.035	0.964
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.035	0.964
M24.9 Joint derangement, unspecified	0.035	0.965
M24.7 Protrusio acetabuli	0.035	0.965
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)	0.035	0.965
M24.1 Other articular cartilage disorders	0.035	0.965
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.035	0.965
M24.5 Contracture of joint	0.035	0.965
M20.4 Other hammer toe(s) (acquired)	0.035	0.965
M32.1 Systemic lupus erythematosus with organ or system involvement	0.034	0.965
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.034	0.966
M21.9 Acquired deformity of limb, unspecified	0.034	0.966
M24.2 Disorder of ligament	0.034	0.966
M21.7 Unequal limb length (acquired)	0.034	0.966
M22.9 Disorder of patella, unspecified	0.034	0.966
M24.44 Recurrent dislocation and subluxation of joint (Hand)	0.033	0.966
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.033	0.966
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.033	0.967
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.033	0.967
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.033	0.967
M22.3 Other derangements of patella	0.033	0.967
M21.2 Flexion deformity	0.033	0.967
M22.2 Patellofemoral disorders	0.033	0.967
M24.39 Pathological dislocation and subluxation of joint, not elsewhere classified (Site unspecified)	0.031	0.968
M24.38 Pathological dislocation and subluxation of joint, not elsewhere classified (Other)	0.031	0.968
M24.36 Pathological dislocation and subluxation of joint, not elsewhere classified (Lower leg)	0.031	0.968
M24.35 Pathological dislocation and subluxation of joint, not elsewhere classified (Pelvic region and thigh)	0.031	0.968
M24.34 Pathological dislocation and subluxation of joint, not elsewhere classified (Hand)	0.031	0.968
M24.33 Pathological dislocation and subluxation of joint, not elsewhere classified (Forearm)	0.031	0.968
M24.32 Pathological dislocation and subluxation of joint, not elsewhere classified (Upper arm)	0.031	0.968
M24.31 Pathological dislocation and subluxation of joint, not elsewhere classified (Shoulder region)	0.031	0.968
M24.30 Pathological dislocation and subluxation of joint, not elsewhere classified (Multiple sites)	0.031	0.968
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.031	0.968
M30.0 Polyarteritis nodosa	0.031	0.968
M62.88 Other specified disorders of muscle (Other)	0.031	0.969
M24.49 Recurrent dislocation and subluxation of joint (Site unspecified)	0.031	0.969
M24.48 Recurrent dislocation and subluxation of joint (Other)	0.031	0.969
M24.46 Recurrent dislocation and subluxation of joint (Lower leg)	0.031	0.969
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.031	0.969
M24.43 Recurrent dislocation and subluxation of joint (Forearm)	0.031	0.969
M24.42 Recurrent dislocation and subluxation of joint (Upper arm)	0.031	0.969
M24.40 Recurrent dislocation and subluxation of joint (Multiple sites)	0.031	0.969
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.031	0.969
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.031	0.969
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.031	0.969
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.031	0.969
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.031	0.969
M80-M85 Disorders of bone density and structure	0.031	0.969
M62.8 Other specified disorders of muscle	0.031	0.969
M21.39 Wrist or foot drop (acquired)-Site unspec	0.030	0.970
M21.38 Wrist or foot drop (acquired)-Other	0.030	0.970
M21.36 Wrist or foot drop (acquired)-Lower leg	0.030	0.970
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.030	0.970
M21.34 Wrist or foot drop (acquired) (Hand)	0.030	0.970
M21.33 Wrist or foot drop (acquired) (Forearm)	0.030	0.970
M21.32 Wrist or foot drop (acquired)-Upper arm	0.030	0.970
M21.31 Wrist or foot drop (acquired)-Shldr region	0.030	0.970
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.030	0.970
M20.0 Deformity of finger(s)	0.030	0.970
M24.17 Other articular cartilage disorders (Ankle and foot)	0.030	0.970
M62 Other disorders of muscle	0.030	0.970
M22.8 Other disorders of patella	0.030	0.970
M22.1 Recurrent subluxation of patella	0.030	0.970
M30.8 Other conditions related to polyarteritis nodosa	0.030	0.970
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.030	0.970
M30.2 Juvenile polyarteritis	0.030	0.970
M24.0 Loose body in joint	0.030	0.970
M81 Osteoporosis without pathological fracture	0.030	0.970
M32.9 Systemic lupus erythematosus, unspecified	0.030	0.970
M32.8 Other forms of systemic lupus erythematosus	0.030	0.970
M32.0 Drug-induced systemic lupus erythematosus	0.030	0.970
M81.99 Osteoporosis, unspecified (Site unspecified)	0.030	0.970
M21.0 Valgus deformity, not elsewhere classified	0.029	0.971
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.029	0.971
M21.68 Other acquired deformities of ankle and foot-Other	0.029	0.971
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.029	0.971
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.029	0.971
M21.64 Other acquired deformities of ankle and foot-Hand	0.029	0.971
M21.63 Other acquired deformities of ankle and foot-Forearm	0.029	0.971
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.029	0.971
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.029	0.971
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.029	0.971
M23 Internal derangement of knee	0.029	0.971
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.029	0.971
M60-M63 Disorders of muscles	0.029	0.971
M81.9 Osteoporosis, unspecified	0.028	0.972
M80 Osteoporosis with pathological fracture	0.028	0.972
M21.49 Flat foot [pes planus] (acquired)-Site unspec	0.028	0.972
M21.48 Flat foot [pes planus] (acquired)-Other	0.028	0.972
M21.46 Flat foot [pes planus] (acquired)-Lower leg	0.028	0.972
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh	0.028	0.972
M21.44 Flat foot [pes planus] (acquired)-Hand	0.028	0.972
M21.43 Flat foot [pes planus] (acquired)-Forearm	0.028	0.972
M21.42 Flat foot [pes planus] (acquired)-Upper arm	0.028	0.972
M21.41 Flat foot [pes planus] (acquired)-Shldr region	0.028	0.972
M21.40 Flat foot [pes planus] (acquired)-Mult sites	0.028	0.972
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.028	0.972
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.028	0.972
M24.67 Ankylosis of joint (Ankle and foot)	0.028	0.972
M85 Other disorders of bone density and structure	0.028	0.972
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.027	0.972
M21.88 Other specified acquired deformities of limbs-Other	0.027	0.972
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.027	0.972
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.027	0.972
M21.84 Other specified acquired deformities of limbs (Hand)	0.027	0.972
M21.83 Other specified acquired deformities of limbs (Forearm)	0.027	0.972
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.027	0.972
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.027	0.972
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.027	0.972
M21.26 Flexion deformity (Lower leg)	0.027	0.973
M33.2 Polymyositis	0.026	0.973
M24.57 Contracture of joint (Ankle and foot)	0.026	0.974
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.026	0.974
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.026	0.974
M36.3 Arthropathy in other blood disorders	0.026	0.974
M36.2 Haemophilic arthropathy	0.026	0.974
M36.1 Arthropathy in neoplastic disease	0.026	0.974
M36.0 Dermato(poly)myositis in neoplastic disease	0.026	0.974
M21.1 Varus deformity, not elsewhere classified	0.026	0.974
M24.51 Contracture of joint (Shoulder region)	0.026	0.974
M24.69 Ankylosis of joint (Site unspecified)	0.026	0.974
M24.68 Ankylosis of joint (Other)	0.026	0.974
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.026	0.974
M24.64 Ankylosis of joint (Hand)	0.026	0.974
M24.63 Ankylosis of joint (Forearm)	0.026	0.974
M24.62 Ankylosis of joint (Upper arm)	0.026	0.974
M24.61 Ankylosis of joint (Shoulder region)	0.026	0.974
M24.60 Ankylosis of joint (Multiple sites)	0.026	0.974
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.026	0.974
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.026	0.974
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.026	0.974
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.026	0.974
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.026	0.974
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.026	0.974
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.026	0.974
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.026	0.974
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.026	0.974
M62.80 Other specified disorders of muscle (Multiple sites)	0.026	0.974
M33.9 Dermatopolymyositis, unspecified	0.026	0.974
M33.0 Juvenile dermatomyositis	0.026	0.974
M80.9 Unspecified osteoporosis with pathological fracture	0.026	0.974
M62.89 Other specified disorders of muscle (Site unspecified)	0.026	0.974
M24.79 Protrusio acetabuli-Site unspec	0.025	0.974
M24.78 Protrusio acetabuli-Other	0.025	0.974
M24.77 Protrusio acetabuli-Ankle/foot	0.025	0.974
M24.76 Protrusio acetabuli-Lower leg	0.025	0.974
M24.75 Protrusio acetabuli-Pelvic/thigh	0.025	0.974
M24.74 Protrusio acetabuli-Hand	0.025	0.974
M24.73 Protrusio acetabuli-Forearm	0.025	0.974
M24.72 Protrusio acetabuli-Upper arm	0.025	0.974
M24.71 Protrusio acetabuli-Shldr region	0.025	0.974
M24.70 Protrusio acetabuli-Mult sites	0.025	0.974
M24.99 Joint derangement, unspecified (Site unspecified)	0.025	0.974
M24.98 Joint derangement, unspecified (Other)	0.025	0.974
M24.97 Joint derangement, unspecified (Ankle and foot)	0.025	0.974
M24.96 Joint derangement, unspecified (Lower leg)	0.025	0.974
M24.95 Joint derangement, unspecified (Pelvic region and thigh)	0.025	0.974
M24.94 Joint derangement, unspecified (Hand)	0.025	0.974
M24.93 Joint derangement, unspecified (Forearm)	0.025	0.974
M24.92 Joint derangement, unspecified (Upper arm)	0.025	0.974
M24.91 Joint derangement, unspecified (Shoulder region)	0.025	0.974
M24.90 Joint derangement, unspecified (Multiple sites)	0.025	0.974
M24.11 Other articular cartilage disorders (Shoulder region)	0.026	0.974
M24.26 Disorder of ligament (Lower leg)	0.025	0.974
M24.23 Disorder of ligament (Forearm)	0.025	0.975
M24.19 Other articular cartilage disorders (Site unspecified)	0.025	0.975
M24.18 Other articular cartilage disorders (Other)	0.025	0.975
M24.14 Other articular cartilage disorders (Hand)	0.025	0.975
M24.12 Other articular cartilage disorders (Upper arm)	0.025	0.975
M24.10 Other articular cartilage disorders (Multiple sites)	0.025	0.975
M23.5 Chronic instability of knee	0.025	0.975
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.025	0.975
M24.59 Contracture of joint (Site unspecified)	0.025	0.975
M24.58 Contracture of joint (Other)	0.025	0.975
M24.55 Contracture of joint (Pelvic region and thigh)	0.025	0.975
M24.53 Contracture of joint (Forearm)	0.025	0.975
M24.52 Contracture of joint (Upper arm)	0.025	0.975
M24.50 Contracture of joint (Multiple sites)	0.025	0.975
M24.54 Contracture of joint (Hand)	0.025	0.975
M23.6 Other spontaneous disruption of ligament(s) of knee	0.025	0.975
M24.66 Ankylosis of joint (Lower leg)	0.025	0.975
M21.27 Flexion deformity (Ankle and foot)	0.025	0.975
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.024	0.975
M21.98 Acquired deformity of limb, unspecified-Other	0.024	0.975
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.024	0.975
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.024	0.975
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.024	0.975
M21.94 Acquired deformity of limb, unspecified (Hand)	0.024	0.975
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.024	0.975
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.024	0.975
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.024	0.975
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.024	0.975
M24.29 Disorder of ligament (Site unspecified)	0.024	0.975
M24.28 Disorder of ligament (Other)	0.024	0.975
M24.25 Disorder of ligament (Pelvic region and thigh)	0.024	0.975
M24.22 Disorder of ligament (Upper arm)	0.024	0.975
M24.20 Disorder of ligament (Multiple sites)	0.024	0.975
M21.79 Unequal limb length (acquired) (Site unspecified)	0.024	0.975
M21.78 Unequal limb length (acquired)-Other	0.024	0.975
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.024	0.975
M21.76 Unequal limb length (acquired) (Lower leg)	0.024	0.975
M21.74 Unequal limb length (acquired) (Hand)	0.024	0.975
M21.73 Unequal limb length (acquired) (Forearm)	0.024	0.975
M21.72 Unequal limb length (acquired) (Upper arm)	0.024	0.975
M21.71 Unequal limb length (acquired)-Shldr region	0.024	0.975
M21.70 Unequal limb length (acquired) (Multiple sites)	0.024	0.975
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.024	0.976
M24.13 Other articular cartilage disorders (Forearm)	0.024	0.976
M33.1 Other dermatomyositis	0.024	0.976
M24.24 Disorder of ligament (Hand)	0.024	0.976
M21.29 Flexion deformity (Site unspecified)	0.024	0.976
M21.28 Flexion deformity (Other)	0.024	0.976
M21.25 Flexion deformity (Pelvic region and thigh)	0.024	0.976
M21.23 Flexion deformity (Forearm)	0.024	0.976
M21.22 Flexion deformity (Upper arm)	0.024	0.976
M21.21 Flexion deformity (Shoulder region)	0.024	0.976
M21.20 Flexion deformity (Multiple sites)	0.024	0.976
Z85.8 Personal history of malignant neoplasms of other organs and systems	0.024	0.976
M24.27 Disorder of ligament (Ankle and foot)	0.023	0.976
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.023	0.976
M81.4 Drug-induced osteoporosis	0.023	0.977
M23.4 Loose body in knee	0.023	0.977
M35 Other systemic involvement of connective tissue	0.023	0.977
M24.03 Loose body in joint (Forearm)	0.023	0.977
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.023	0.977
M85.9 Disorder of bone density and structure, unspecified	0.023	0.977
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.023	0.977
M62.6 Muscle strain	0.023	0.977
M45-M49 Spondylopathies	0.023	0.977
M81.2 Osteoporosis of disuse	0.023	0.977
M80.0 Postmenopausal osteoporosis with pathological fracture	0.023	0.977
M24.16 Other articular cartilage disorders (Lower leg)	0.023	0.977
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.022	0.977
M83 Adult osteomalacia	0.022	0.978
M85.0 Fibrous dysplasia (monostotic)	0.022	0.978
M20.5 Other deformities of toe(s) (acquired)	0.022	0.978
M81.0 Postmenopausal osteoporosis	0.022	0.978
M62.87 Other specified disorders of muscle (Ankle and foot)	0.022	0.978
M62.84 Other specified disorders of muscle (Hand)	0.022	0.978
M62.83 Other specified disorders of muscle (Forearm)	0.022	0.978
M62.82 Other specified disorders of muscle (Upper arm)	0.022	0.978
M85.2 Hyperostosis of skull	0.022	0.978
M81.93 Osteoporosis, unspecified (Forearm)	0.022	0.978
M24.21 Disorder of ligament (Shoulder region)	0.022	0.978
M84 Disorders of continuity of bone	0.022	0.978
M23.61 Other spontaneous disruption of ligament(s) of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.022	0.978
M24.07 Loose body in joint (Ankle and foot)	0.022	0.978
M62.9 Disorder of muscle, unspecified	0.022	0.978
M62.4 Contracture of muscle	0.022	0.978
M62.3 Immobility syndrome (paraplegic)	0.022	0.978
M62.2 Ischaemic infarction of muscle	0.022	0.978
M62.1 Other rupture of muscle (nontraumatic)	0.022	0.978
M62.0 Diastasis of muscle	0.022	0.978
M46 Other inflammatory spondylopathies	0.022	0.978
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.022	0.978
M22.10 Recurrent subluxation of patella, unspecified knee	0.022	0.978
M24.09 Loose body in joint (Site unspecified)	0.022	0.978
M24.08 Loose body in joint (Other)	0.022	0.978
M24.06 Loose body in joint-Lower leg	0.022	0.978
M24.05 Loose body in joint (Pelvic region and thigh)	0.022	0.978
M24.04 Loose body in joint (Hand)	0.022	0.978
M24.00 Loose body in joint (Multiple sites)	0.022	0.978
M24.56 Contracture of joint (Lower leg)	0.021	0.978
M81.8 Other osteoporosis	0.022	0.978
M81.6 Localised osteoporosis [Lequesne]	0.022	0.978
M81.5 Idiopathic osteoporosis	0.022	0.978
M81.3 Postsurgical malabsorption osteoporosis	0.022	0.978
M81.1 Postoophorectomy osteoporosis	0.022	0.978
M23.9 Internal derangement of knee, unspecified	0.022	0.978
M32.90 Systemic lupus erythematosus, unspecified, Multiple sites	0.021	0.978
M00-M03 Infectious arthropathies	0.021	0.978
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.021	0.979
M21.08 Valgus deformity, not elsewhere classified (Other)	0.021	0.979
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.021	0.979
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.021	0.979
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.021	0.979
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.021	0.979
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.021	0.979
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.021	0.979
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.021	0.979
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.021	0.979
M23.1 Discoid meniscus (congenital)	0.021	0.979
M23.0 Cystic meniscus	0.021	0.979
M48.5 Collapsed vertebra, not elsewhere classified	0.021	0.979
M63 Disorders of muscle in diseases classified elsewhere	0.021	0.979
M61 Calcification and ossification of muscle	0.021	0.979
M85.6 Other cyst of bone	0.021	0.979
M24.01 Loose body in joint (Shoulder region)	0.020	0.979
M81.94 Osteoporosis, unspecified (Hand)	0.020	0.979
M81.92 Osteoporosis, unspecified (Upper arm)	0.020	0.979
M81.91 Osteoporosis, unspecified (Shoulder region)	0.020	0.979
M40-M43 Deforming dorsopathies	0.021	0.979
M80.4 Drug-induced osteoporosis with pathological fracture	0.020	0.979
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.020	0.979
M80.2 Osteoporosis of disuse with pathological fracture	0.020	0.979
M60 Myositis	0.020	0.979
M48 Other spondylopathies	0.020	0.980
M80.8 Other osteoporosis with pathological fracture	0.020	0.980
M62.81 Other specified disorders of muscle (Shoulder region)	0.020	0.980
M62.56 Muscle wasting and atrophy, not elsewhere classified (Lower leg)	0.020	0.980
M91-M94 Chondropathies	0.020	0.980
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.020	0.980
M86-M90 Other osteopathies	0.020	0.980
M85.5 Aneurysmal bone cyst	0.020	0.980
M85.4 Solitary bone cyst	0.020	0.980
M85.3 Osteitis condensans	0.020	0.980
M85.1 Skeletal fluorosis	0.020	0.980
M20.3 Other deformity of hallux (acquired)	0.020	0.980
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.020	0.980
M81.96 Osteoporosis, unspecified (Lower leg)	0.020	0.980
M82 Osteoporosis in diseases classified elsewhere	0.020	0.980
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.019	0.980
M62.50 Muscle wasting and atrophy, not elsewhere classified (Multiple sites)	0.019	0.980
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.019	0.981
M62.59 Muscle wasting and atrophy, not elsewhere classified (Site unspecified)	0.019	0.981
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.019	0.981
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.019	0.981
M21.18 Varus deformity, not elsewhere classified (Other)	0.019	0.981
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.019	0.981
M21.14 Varus deformity, not elsewhere classified (Hand)	0.019	0.981
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.019	0.981
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.019	0.981
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.019	0.981
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.019	0.981
M35.7 Hypermobility syndrome	0.019	0.981
M25 Other joint disorders, not elsewhere classified	0.019	0.981
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.019	0.981
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.019	0.981
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.019	0.981
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.019	0.981
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.019	0.981
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.019	0.981
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.019	0.981
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.019	0.981
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.019	0.981
M23.49 Loose body in knee-Unspec lig/men	0.019	0.981
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.019	0.981
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.018	0.981
M85.8 Other specified disorders of bone density and structure	0.018	0.981
M46.2 Osteomyelitis of vertebra	0.018	0.981
M23.57 Chronic instability of knee (Capsular ligament)	0.018	0.982
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.018	0.982
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.018	0.982
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.018	0.982
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.018	0.982
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.018	0.982
M23.50 Chronic instability of knee (Multiple sites)	0.018	0.982
M85.20 Hyperostosis of skull-Mult sites	0.018	0.982
M62.58 Muscle wasting and atrophy, not elsewhere classified (Other)	0.018	0.982
M62.57 Muscle wasting and atrophy, not elsewhere classified (Ankle and foot)	0.018	0.982
M62.55 Muscle wasting and atrophy, not elsewhere classified (Pelvic region and thigh)	0.018	0.982
M62.54 Muscle wasting and atrophy, not elsewhere classified (Hand)	0.018	0.982
M62.53 Muscle wasting and atrophy, not elsewhere classified (Forearm)	0.018	0.982
M62.52 Muscle wasting and atrophy, not elsewhere classified (Upper arm)	0.018	0.982
M62.51 Muscle wasting and atrophy, not elsewhere classified (Shoulder region)	0.018	0.982
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.018	0.982
M81.49 Drug-induced osteoporosis (Site unspecified)	0.018	0.982
M84.2 Delayed union of fracture	0.018	0.982
M80.5 Idiopathic osteoporosis with pathological fracture	0.018	0.982
M46.4 Discitis, unspecified	0.018	0.982
M31 Other necrotising vasculopathies	0.018	0.982
M23.69 Other spontaneous disruption of ligament(s) of knee (Unspecified ligament or Unspecified meniscus)	0.018	0.982
M23.67 Other spontaneous disruption of ligament(s) of knee (Capsular ligament)	0.018	0.982
M23.66 Other spontaneous disruption of ligament(s) of knee-O/unsp	0.018	0.982
M23.65 Other spontaneous disruption of ligament(s) of knee-Pst hrn	0.018	0.982
M23.64 Other spontaneous disruption of ligament(s) of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.018	0.982
M23.63 Other spontaneous disruption of ligament(s) of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.018	0.982
M23.62 Other spontaneous disruption of ligament(s) of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.018	0.982
M23.60 Other spontaneous disruption of ligament(s) of knee (Multiple sites)	0.018	0.982
M23.43 Loose body in knee-Med lig/oth men	0.018	0.982
M81.20 Osteoporosis of disuse (Multiple sites)	0.018	0.982
M62.65 Muscle strain (Pelvic region and thigh)	0.018	0.982
M46.9 Inflammatory spondylopathy, unspecified	0.018	0.982
M81.40 Drug-induced osteoporosis (Multiple sites)	0.018	0.982
M46.0 Spinal enthesopathy	0.018	0.982
M40 Kyphosis and lordosis	0.018	0.982
M48.55 Collapsed vertebra, not elsewhere classified (Thoracolumbar region)	0.017	0.983
M81.90 Osteoporosis, unspecified (Multiple sites)	0.017	0.983
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.017	0.983
M25.3 Other instability of joint	0.017	0.983
M25.7 Osteophyte	0.017	0.983
M81.48 Drug-induced osteoporosis (Other)	0.017	0.983
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.017	0.983
M81.46 Drug-induced osteoporosis (Lower leg)	0.017	0.983
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.017	0.983
M81.44 Drug-induced osteoporosis (Hand)	0.017	0.983
M81.43 Drug-induced osteoporosis (Forearm)	0.017	0.983
M81.42 Drug-induced osteoporosis (Upper arm)	0.017	0.983
M81.41 Drug-induced osteoporosis (Shoulder region)	0.017	0.983
M23.47 Loose body in knee-Capsular lig	0.017	0.983
M23.45 Loose body in knee-Pst hrn lat men	0.017	0.983
M23.44 Loose body in knee-Lat lig/ant men	0.017	0.983
M23.42 Loose body in knee-Pst lig/hrn men	0.017	0.983
M23.41 Loose body in knee-Ant lig/hrn men	0.017	0.983
M23.40 Loose body in knee-Mult sites	0.017	0.983
M35.9 Systemic involvement of connective tissue, unspecified	0.017	0.983
M35.8 Other specified systemic involvement of connective tissue	0.017	0.983
M35.6 Relapsing panniculitis [Weber-Christian]	0.017	0.983
M35.5 Multifocal fibrosclerosis	0.017	0.983
M35.4 Diffuse (eosinophilic) fasciitis	0.017	0.983
M35.2 Behcet's disease	0.017	0.983
M23.46 Loose body in knee-O/unsp lat men	0.017	0.983
M25.76 Osteophyte (Lower leg)	0.017	0.983
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.017	0.983
M62.86 Other specified disorders of muscle (Lower leg)	0.017	0.983
M85.98 Disorder of bone density and structure, unspecified (Other)	0.017	0.983
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.017	0.983
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.017	0.983
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.017	0.983
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.017	0.983
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.017	0.983
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.017	0.983
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.017	0.983
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.017	0.983
M81.09 Postmenopausal osteoporosis (Site unspecified)	0.017	0.983
L59 Other disorders of skin and subcutaneous tissue related to radiation	0.017	0.983
L58 Radiodermatitis	0.017	0.983
L55 Sunburn	0.017	0.983
M49 Spondylopathies in diseases classified elsewhere	0.017	0.983
M62.69 Muscle strain (Site unspecified)	0.017	0.983
M62.68 Muscle strain (Other)	0.017	0.983
M62.67 Muscle strain (Ankle and foot)	0.017	0.983
M62.66 Muscle strain (Lower leg)	0.017	0.983
M62.64 Muscle strain (Hand)	0.017	0.983
M62.63 Muscle strain (Forearm)	0.017	0.983
M62.62 Muscle strain (Upper arm)	0.017	0.983
M62.61 Muscle strain (Shoulder region)	0.017	0.983
M62.60 Muscle strain (Multiple sites)	0.017	0.983
M00 Pyogenic arthritis	0.017	0.983
M81.29 Osteoporosis of disuse (Site unspecified)	0.017	0.983
M81.28 Osteoporosis of disuse (Other)	0.017	0.983
M81.27 Osteoporosis of disuse (Ankle and foot)	0.017	0.983
M81.26 Osteoporosis of disuse (Lower leg)	0.017	0.983
M81.25 Osteoporosis of disuse (Pelvic region and thigh)	0.017	0.983
M81.24 Osteoporosis of disuse (Hand)	0.017	0.983
M81.23 Osteoporosis of disuse (Forearm)	0.017	0.983
M81.22 Osteoporosis of disuse (Upper arm)	0.017	0.983
M81.21 Osteoporosis of disuse (Shoulder region)	0.017	0.983
M46.3 Infection of intervertebral disk (pyogenic)	0.017	0.983

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations