TreeWAS – Variant ID: rs8009420

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M51 Other intervertebral disk disorders	0.771	0.229	0.000
M50-M54 Other dorsopathies	0.767	0.233	0.000
M80-M85 Disorders of bone density and structure	0.757	0.243	0.000
M51.2 Other specified intervertebral disk displacement	0.754	0.246	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.752	0.248	0.000
M81 Osteoporosis without pathological fracture	0.746	0.254	0.000
M81.9 Osteoporosis, unspecified	0.736	0.264	0.000
M85 Other disorders of bone density and structure	0.729	0.271	0.000
M81.99 Osteoporosis, unspecified (Site unspecified)	0.724	0.276	0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy	0.699	0.301	0.000
M20-M25 Other joint disorders	0.678	0.322	0.000
M86-M90 Other osteopathies	0.674	0.326	0.000
M51.8 Other specified intervertebral disk disorders	0.664	0.336	0.000
M60-M63 Disorders of muscles	0.662	0.338	0.000
M25 Other joint disorders, not elsewhere classified	0.662	0.338	0.000
M85.6 Other cyst of bone	0.651	0.349	0.000
M53 Other dorsopathies, not elsewhere classified	0.650	0.350	0.000
M51.9 Intervertebral disk disorder, unspecified	0.644	0.356	0.000
M54 Dorsalgia	0.636	0.364	0.000
M84 Disorders of continuity of bone	0.632	0.368	0.000
M25.5 Pain in joint	0.631	0.369	0.000
M85.0 Fibrous dysplasia (monostotic)	0.624	0.376	0.000
M85.8 Other specified disorders of bone density and structure	0.622	0.378	0.000
M00-M03 Infectious arthropathies	0.620	0.380	0.000
M25.55 Pain in joint (Pelvic region and thigh)	0.615	0.385	0.000
M87 Osteonecrosis	0.605	0.395	0.000
M51.3 Other specified intervertebral disk degeneration	0.602	0.398	0.000
M81.93 Osteoporosis, unspecified (Forearm)	0.597	0.403	0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.597	0.403	0.000
M62 Other disorders of muscle	0.594	0.406	0.000
M50 Cervical disk disorders	0.594	0.406	0.000
M30 Polyarteritis nodosa and related conditions	0.591	0.409	0.000
M25.8 Other specified joint disorders	0.582	0.418	0.000
M25.0 Haemarthrosis	0.578	0.422	0.000
M81.4 Drug-induced osteoporosis	0.570	0.430	0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.566	0.434	0.000
M25.3 Other instability of joint	0.566	0.434	0.000
M82 Osteoporosis in diseases classified elsewhere	0.564	0.435	0.000
M51.4 Schmorl's nodes	0.563	0.437	0.000
M54.4 Lumbago with sciatica	0.563	0.437	0.000
M85.65 Other cyst of bone (Pelvic region and thigh)	0.559	0.441	0.000
M50.2 Other cervical disk displacement	0.557	0.443	0.000
M89 Other disorders of bone	0.555	0.445	0.000
M81.98 Osteoporosis, unspecified (Other)	0.553	0.447	0.000
M51.1 Lumbar and other intervertebral disk disorders with radiculopathy	0.553	0.447	0.000
M84.0 Malunion of fracture	0.552	0.448	0.000
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.548	0.452	0.000
M83 Adult osteomalacia	0.543	0.457	0.000
M24 Other specific joint derangements	0.541	0.459	0.000
M25.59 Pain in joint (Site unspecified)	0.539	0.461	0.000
M85.64 Other cyst of bone (Hand)	0.538	0.462	0.000
M25.51 Pain in joint (Shoulder region)	0.538	0.462	0.000
M81.8 Other osteoporosis	0.535	0.465	0.000
M81.6 Localised osteoporosis [Lequesne]	0.535	0.465	0.000
M81.5 Idiopathic osteoporosis	0.535	0.465	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.535	0.465	0.000
M81.1 Postoophorectomy osteoporosis	0.535	0.465	0.000
M81.0 Postmenopausal osteoporosis	0.535	0.465	0.000
M62.8 Other specified disorders of muscle	0.529	0.471	0.000
M34 Systemic sclerosis	0.529	0.471	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.529	0.471	0.000
M81.96 Osteoporosis, unspecified (Lower leg)	0.528	0.472	0.000
M81.94 Osteoporosis, unspecified (Hand)	0.528	0.472	0.000
M81.92 Osteoporosis, unspecified (Upper arm)	0.528	0.472	0.000
M81.91 Osteoporosis, unspecified (Shoulder region)	0.528	0.472	0.000
M91-M94 Chondropathies	0.525	0.475	0.000
M85.9 Disorder of bone density and structure, unspecified	0.523	0.477	0.000
M85.5 Aneurysmal bone cyst	0.523	0.477	0.000
M85.4 Solitary bone cyst	0.523	0.477	0.000
M85.3 Osteitis condensans	0.523	0.477	0.000
M85.2 Hyperostosis of skull	0.523	0.477	0.000
M85.1 Skeletal fluorosis	0.523	0.477	0.000
M05-M14 Inflammatory polyarthropathies	0.522	0.478	0.000
M81.2 Osteoporosis of disuse	0.521	0.479	0.000
M54.1 Radiculopathy	0.521	0.479	0.000
M25.84 Other specified joint disorders (Hand)	0.520	0.480	0.000
M54.6 Pain in thoracic spine	0.519	0.481	0.000
M33 Dermatopolymyositis	0.518	0.482	0.000
M25.06 Haemarthrosis (Lower leg)	0.518	0.482	0.000
M21 Other acquired deformities of limbs	0.517	0.483	0.000
M40-M43 Deforming dorsopathies	0.517	0.483	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.512	0.488	0.000
M87.2 Osteonecrosis due to previous trauma	0.508	0.492	0.000
M80 Osteoporosis with pathological fracture	0.507	0.493	0.000
M53.38 Sacrococcygeal disorders, not elsewhere classified-Sacral/s	0.506	0.494	0.000
M25.81 Other specified joint disorders (Shoulder region)	0.504	0.496	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.503	0.497	0.000
M54.9 Dorsalgia, unspecified	0.501	0.499	0.000
M25.57 Pain in joint (Ankle and foot)	0.498	0.502	0.000
M00 Pyogenic arthritis	0.496	0.504	0.000
M87.9 Osteonecrosis, unspecified	0.496	0.504	0.000
M86 Osteomyelitis	0.492	0.508	0.000
M85.85 Other specified disorders of bone density and structure (Pelvic region and thigh)	0.492	0.508	0.000
M54.46 Lumbago with sciatica (Lumbar region)	0.490	0.510	0.000
M32 Systemic lupus erythematosus	0.488	0.512	0.000
M60 Myositis	0.486	0.514	0.000
M02 Reactive arthropathies	0.486	0.514	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.486	0.514	0.000
M25.9 Joint disorder, unspecified	0.485	0.515	0.000
M25.53 Pain in joint (Forearm)	0.482	0.518	0.000
M54.8 Other dorsalgia	0.481	0.519	0.000
M51.37 Other intervertebral disc degeneration, lumbosacral region	0.481	0.519	0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.480	0.520	0.000
M25.50 Pain in joint (Multiple sites)	0.479	0.521	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.475	0.525	0.000
M61 Calcification and ossification of muscle	0.475	0.525	0.000
M25.2 Flail joint	0.475	0.525	0.000
M25.1 Fistula of joint	0.475	0.525	0.000
M62.88 Other specified disorders of muscle (Other)	0.472	0.528	0.000
M24.0 Loose body in joint	0.472	0.528	0.000
M87.8 Other osteonecrosis	0.468	0.532	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.467	0.533	0.000
M85.69 Other cyst of bone (Site unspecified)	0.467	0.533	0.000
M85.68 Other cyst of bone (Other)	0.467	0.533	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.467	0.533	0.000
M85.66 Other cyst of bone (Lower leg)	0.467	0.533	0.000
M85.63 Other cyst of bone (Forearm)	0.467	0.533	0.000
M85.62 Other cyst of bone (Upper arm)	0.467	0.533	0.000
M85.61 Other cyst of bone (Shoulder region)	0.467	0.533	0.000
M85.60 Other cyst of bone (Multiple sites)	0.467	0.533	0.000
M53.9 Dorsopathy, unspecified	0.466	0.534	0.000
M53.8 Other specified dorsopathies	0.466	0.534	0.000
M53.2 Spinal instabilities	0.466	0.534	0.000
M53.1 Cervicobrachial syndrome	0.466	0.534	0.000
M53.0 Cervicocranial syndrome	0.466	0.534	0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)	0.459	0.541	0.000
M21.1 Varus deformity, not elsewhere classified	0.458	0.542	0.000
M25.37 Other instability of joint (Ankle and foot)	0.458	0.542	0.000
M25.4 Effusion of joint	0.458	0.542	0.000
M89.0 Algoneurodystrophy	0.456	0.543	0.000
M54.0 Panniculitis affecting regions of neck and back	0.456	0.544	0.000
M84.4 Pathological fracture, not elsewhere classified	0.455	0.545	0.000
M84.9 Disorder of continuity of bone, unspecified	0.453	0.546	0.000
M84.8 Other disorders of continuity of bone	0.453	0.546	0.000
M84.3 Stress fracture, not elsewhere classified	0.453	0.546	0.000
M84.2 Delayed union of fracture	0.453	0.546	0.000
M88 Paget's disease of bone [osteitis deformans]	0.452	0.548	0.000
M22 Disorders of patella	0.450	0.550	0.000
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.447	0.553	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.447	0.553	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.447	0.553	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.447	0.553	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.447	0.553	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.447	0.553	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.447	0.553	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.447	0.553	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.447	0.553	0.000
M90 Osteopathies in diseases classified elsewhere	0.447	0.553	0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.446	0.554	0.000
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.446	0.554	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.446	0.554	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.446	0.554	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.446	0.554	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.446	0.554	0.000
M05 Seropositive rheumatoid arthritis	0.446	0.554	0.000
M54.47 Lumbago with sciatica (Lumbosacral region)	0.446	0.554	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.445	0.555	0.000
M03 Postinfective and reactive arthropathies in diseases classified elsewhere	0.444	0.555	0.000
M01 Direct infections of joint in infectious and parasitic diseases classified elsewhere	0.444	0.555	0.000
M25.31 Other instability of joint (Shoulder region)	0.441	0.559	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.440	0.560	0.000
M84.01 Malunion of fracture (Shoulder region)	0.439	0.561	0.000
M81.49 Drug-induced osteoporosis (Site unspecified)	0.439	0.561	0.000
M87.20 Osteonecrosis due to previous trauma (Multiple sites)	0.438	0.561	0.000
M50.1 Cervical disk disorder with radiculopathy	0.438	0.562	0.000
M84.03 Malunion of fracture (Forearm)	0.438	0.562	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.436	0.564	0.000
M25.34 Other instability of joint (Hand)	0.436	0.564	0.000
M54.64 Pain in thoracic spine (Thoracic region)	0.434	0.566	0.000
M87.3 Other secondary osteonecrosis	0.434	0.566	0.000
M87.1 Osteonecrosis due to drugs	0.434	0.566	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.434	0.566	0.000
M84.06 Malunion of fracture (Lower leg)	0.430	0.569	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.430	0.570	0.000
M84.02 Malunion of fracture (Upper arm)	0.428	0.572	0.000
M24.6 Ankylosis of joint	0.428	0.572	0.000
M82.1 Osteoporosis in endocrine disorders	0.426	0.574	0.000
M62.9 Disorder of muscle, unspecified	0.426	0.574	0.000
M62.6 Muscle strain	0.426	0.574	0.000
M62.4 Contracture of muscle	0.426	0.574	0.000
M62.3 Immobility syndrome (paraplegic)	0.426	0.574	0.000
M62.2 Ischaemic infarction of muscle	0.426	0.574	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.426	0.574	0.000
M62.0 Diastasis of muscle	0.426	0.574	0.000
M50.9 Cervical disk disorder, unspecified	0.426	0.574	0.000
M50.8 Other cervical disk disorders	0.426	0.574	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.424	0.576	0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.424	0.576	0.000
M30.2 Juvenile polyarteritis	0.424	0.576	0.000
M30.0 Polyarteritis nodosa	0.424	0.576	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.422	0.577	0.000
M35 Other systemic involvement of connective tissue	0.421	0.579	0.000
M54.19 Radiculopathy (Site unspecified)	0.420	0.580	0.000
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.420	0.580	0.000
M21.6 Other acquired deformities of ankle and foot	0.419	0.581	0.000
M25.89 Other specified joint disorders (Site unspecified)	0.417	0.582	0.000
M25.88 Other specified joint disorders (Other)	0.417	0.582	0.000
M25.82 Other specified joint disorders (Upper arm)	0.417	0.582	0.000
M25.80 Other specified joint disorders (Multiple sites)	0.417	0.582	0.000
M25.83 Other specified joint disorders (Forearm)	0.416	0.584	0.000
M81.40 Drug-induced osteoporosis (Multiple sites)	0.415	0.585	0.000
M89.8 Other specified disorders of bone	0.415	0.585	0.000
M25.09 Haemarthrosis (Site unspecified)	0.414	0.585	0.000
M25.08 Haemarthrosis (Other)	0.414	0.585	0.000
M25.07 Haemarthrosis (Ankle and foot)	0.414	0.585	0.000
M25.05 Haemarthrosis (Pelvic region and thigh)	0.414	0.585	0.000
M25.04 Haemarthrosis (Hand)	0.414	0.585	0.000
M25.03 Haemarthrosis (Forearm)	0.414	0.585	0.000
M25.02 Haemarthrosis (Upper arm)	0.414	0.585	0.000
M25.01 Haemarthrosis (Shoulder region)	0.414	0.585	0.000
M25.00 Haemarthrosis (Multiple sites)	0.414	0.585	0.000
M34.9 Systemic sclerosis, unspecified	0.414	0.586	0.000
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.413	0.587	0.000
M81.48 Drug-induced osteoporosis (Other)	0.409	0.591	0.000
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.409	0.591	0.000
M81.46 Drug-induced osteoporosis (Lower leg)	0.409	0.591	0.000
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.409	0.591	0.000
M81.44 Drug-induced osteoporosis (Hand)	0.409	0.591	0.000
M81.43 Drug-induced osteoporosis (Forearm)	0.409	0.591	0.000
M81.42 Drug-induced osteoporosis (Upper arm)	0.409	0.591	0.000
M81.41 Drug-induced osteoporosis (Shoulder region)	0.409	0.591	0.000
M00.9 Pyogenic arthritis, unspecified	0.408	0.592	0.000
M53.39 Sacrococcygeal disorders, not elsewhere classified-Site uns	0.406	0.594	0.000
M53.37 Sacrococcygeal disorders, not elsewhere classified-Lumbosac	0.406	0.594	0.000
M53.36 Sacrococcygeal disorders, not elsewhere classified-Lumbar	0.406	0.594	0.000
M53.35 Sacrococcygeal disorders, not elsewhere classified-Thoracol	0.406	0.594	0.000
M53.34 Sacrococcygeal disorders, not elsewhere classified-Thoracic	0.406	0.594	0.000
M53.33 Sacrococcygeal disorders, not elsewhere classified-Cervicot	0.406	0.594	0.000
M53.32 Sacrococcygeal disorders, not elsewhere classified-Cervical	0.406	0.594	0.000
M53.31 Sacrococcygeal disorders, not elsewhere classified-Occipit-	0.406	0.594	0.000
M53.30 Sacrococcygeal disorders, not elsewhere classified-Mult sit	0.406	0.594	0.000
M25.39 Other instability of joint (Site unspecified)	0.406	0.594	0.000
M25.38 Other instability of joint (Other)	0.406	0.594	0.000
M25.36 Other instability of joint (Lower leg)	0.406	0.594	0.000
M25.35 Other instability of joint (Pelvic region and thigh)	0.406	0.594	0.000
M25.33 Other instability of joint (Forearm)	0.406	0.594	0.000
M25.32 Other instability of joint (Upper arm)	0.406	0.594	0.000
M25.30 Other instability of joint (Multiple sites)	0.406	0.594	0.000
M54.99 Dorsalgia, unspecified (Site unspecified)	0.405	0.595	0.000
M82.8 Osteoporosis in other diseases classified elsewhere	0.405	0.595	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.405	0.595	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.405	0.595	0.000
M89.9 Disorder of bone, unspecified	0.405	0.595	0.000
M54.49 Lumbago with sciatica (Site unspecified)	0.404	0.595	0.000
M54.48 Lumbago with sciatica (Sacral and sacrococcygeal region)	0.403	0.596	0.000
M54.45 Lumbago with sciatica (Thoracolumbar region)	0.403	0.596	0.000
M54.44 Lumbago with sciatica-Thoracic	0.403	0.596	0.000
M54.43 Lumbago with sciatica-Cervicothoracic	0.403	0.596	0.000
M54.42 Lumbago with sciatica-Cervical	0.403	0.596	0.000
M54.41 Lumbago with sciatica-Occipit-atl-axl	0.403	0.596	0.000
M54.40 Lumbago with sciatica (Multiple sites in spine)	0.403	0.596	0.000
M06 Other rheumatoid arthritis	0.402	0.598	0.000
M25.58 Pain in joint (Other)	0.400	0.600	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.398	0.601	0.000
M89.6 Osteopathy after poliomyelitis	0.398	0.602	0.000
M89.5 Osteolysis	0.398	0.602	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.398	0.602	0.000
M89.3 Hypertrophy of bone	0.398	0.602	0.000
M89.2 Other disorders of bone development and growth	0.398	0.602	0.000
M89.1 Epiphyseal arrest	0.398	0.602	0.000
M25.86 Other specified joint disorders (Lower leg)	0.398	0.602	0.000
M51.19 Lumbar and other intervertebral disc disorders with radiculopathy; site unspecified	0.396	0.603	0.000
M51.16 Intervertebral disc disorders w radiculopathy, lumbar region	0.396	0.603	0.000
M84.09 Malunion of fracture (Site unspecified)	0.396	0.604	0.000
M84.08 Malunion of fracture (Other)	0.396	0.604	0.000
M84.05 Malunion of fracture (Pelvic region and thigh)	0.396	0.604	0.000
M84.04 Malunion of fracture (Hand)	0.396	0.604	0.000
M84.00 Malunion of fracture (Multiple sites)	0.396	0.604	0.000
M54.92 Dorsalgia, unspecified (Cervical region)	0.396	0.604	0.000
M24.03 Loose body in joint (Forearm)	0.395	0.605	0.000
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)	0.395	0.605	0.000
M92 Other juvenile osteochondrosis	0.394	0.606	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.394	0.606	0.000
M21.4 Flat foot [pes planus] (acquired)	0.393	0.607	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.392	0.608	0.000
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.391	0.609	0.000
M33.1 Other dermatomyositis	0.390	0.610	0.000
M02.3 Reiter's disease	0.390	0.610	0.000
M83.9 Adult osteomalacia, unspecified	0.389	0.610	0.000
M83.8 Other adult osteomalacia	0.389	0.610	0.000
M83.5 Other drug-induced osteomalacia in adults	0.389	0.610	0.000
M83.4 Aluminum bone disease	0.389	0.610	0.000
M83.3 Adult osteomalacia due to malnutrition	0.389	0.610	0.000
M83.2 Adult osteomalacia due to malabsorption	0.389	0.610	0.000
M83.1 Senile osteomalacia	0.389	0.610	0.000
M83.0 Puerperal osteomalacia	0.389	0.610	0.000
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.389	0.611	0.000
M34.1 CR(E)ST syndrome	0.388	0.611	0.000
M24.9 Joint derangement, unspecified	0.388	0.612	0.000
M24.7 Protrusio acetabuli	0.388	0.612	0.000
M33.2 Polymyositis	0.387	0.613	0.000
M25.87 Other specified joint disorders (Ankle and foot)	0.386	0.614	0.000
M24.02 Loose body in joint (Upper arm)	0.385	0.615	0.000
M54.12 Radiculopathy (Cervical region)	0.385	0.615	0.000
M41 Scoliosis	0.385	0.615	0.000
M87.91 Osteonecrosis, unspecified (Shoulder region)	0.385	0.615	0.000
M25.52 Pain in joint (Upper arm)	0.384	0.616	0.000
M81.09 Postmenopausal osteoporosis (Site unspecified)	0.383	0.616	0.000
M81.08 Postmenopausal osteoporosis (Other)	0.383	0.616	0.000
M81.07 Postmenopausal osteoporosis (Ankle and foot)	0.383	0.616	0.000
M81.06 Postmenopausal osteoporosis (Lower leg)	0.383	0.616	0.000
M81.05 Postmenopausal osteoporosis (Pelvic region and thigh)	0.383	0.616	0.000
M81.04 Postmenopausal osteoporosis (Hand)	0.383	0.616	0.000
M81.03 Postmenopausal osteoporosis (Forearm)	0.383	0.616	0.000
M81.02 Postmenopausal osteoporosis (Upper arm)	0.383	0.616	0.000
M81.01 Postmenopausal osteoporosis (Shoulder region)	0.383	0.616	0.000
M81.00 Postmenopausal osteoporosis (Multiple sites)	0.383	0.616	0.000
M81.19 Postoophorectomy osteoporosis (Site unspecified)	0.383	0.616	0.000
M81.18 Postoophorectomy osteoporosis (Other)	0.383	0.616	0.000
M81.17 Postoophorectomy osteoporosis (Ankle and foot)	0.383	0.616	0.000
M81.16 Postoophorectomy osteoporosis (Lower leg)	0.383	0.616	0.000
M81.15 Postoophorectomy osteoporosis (Pelvic region and thigh)	0.383	0.616	0.000
M81.14 Postoophorectomy osteoporosis (Hand)	0.383	0.616	0.000
M81.13 Postoophorectomy osteoporosis (Forearm)	0.383	0.616	0.000
M81.12 Postoophorectomy osteoporosis (Upper arm)	0.383	0.616	0.000
M81.11 Postoophorectomy osteoporosis (Shoulder region)	0.383	0.616	0.000
M81.10 Postoophorectomy osteoporosis (Multiple sites)	0.383	0.616	0.000
M81.39 Postsurgical malabsorption osteoporosis (Site unspecified)	0.383	0.616	0.000
M81.38 Postsurgical malabsorption osteoporosis (Other)	0.383	0.616	0.000
M81.37 Postsurgical malabsorption osteoporosis (Ankle and foot)	0.383	0.616	0.000
M81.36 Postsurgical malabsorption osteoporosis (Lower leg)	0.383	0.616	0.000
M81.35 Postsurgical malabsorption osteoporosis (Pelvic region and thigh)	0.383	0.616	0.000
M81.34 Postsurgical malabsorption osteoporosis (Hand)	0.383	0.616	0.000
M81.33 Postsurgical malabsorption osteoporosis (Forearm)	0.383	0.616	0.000
M81.32 Postsurgical malabsorption osteoporosis (Upper arm)	0.383	0.616	0.000
M81.31 Postsurgical malabsorption osteoporosis (Shoulder region)	0.383	0.616	0.000
M81.30 Postsurgical malabsorption osteoporosis (Multiple sites)	0.383	0.616	0.000
M81.59 Idiopathic osteoporosis (Site unspecified)	0.383	0.616	0.000
M81.58 Idiopathic osteoporosis (Other)	0.383	0.616	0.000
M81.57 Idiopathic osteoporosis (Ankle and foot)	0.383	0.616	0.000
M81.56 Idiopathic osteoporosis (Lower leg)	0.383	0.616	0.000
M81.55 Idiopathic osteoporosis (Pelvic region and thigh)	0.383	0.616	0.000
M81.54 Idiopathic osteoporosis (Hand)	0.383	0.616	0.000
M81.53 Idiopathic osteoporosis (Forearm)	0.383	0.616	0.000
M81.52 Idiopathic osteoporosis (Upper arm)	0.383	0.616	0.000
M81.51 Idiopathic osteoporosis (Shoulder region)	0.383	0.616	0.000
M81.50 Idiopathic osteoporosis (Multiple sites)	0.383	0.616	0.000
M81.69 Localized osteoporosis [Lequesne] (Site unspecified)	0.383	0.616	0.000
M81.68 Localized osteoporosis [Lequesne] (Other)	0.383	0.616	0.000
M81.67 Localized osteoporosis [Lequesne] (Ankle and foot)	0.383	0.616	0.000
M81.66 Localized osteoporosis [Lequesne] (Lower leg)	0.383	0.616	0.000
M81.65 Localized osteoporosis [Lequesne] (Pelvic region and thigh)	0.383	0.616	0.000
M81.64 Localized osteoporosis [Lequesne] (Hand)	0.383	0.616	0.000
M81.63 Localized osteoporosis [Lequesne] (Forearm)	0.383	0.616	0.000
M81.62 Localized osteoporosis [Lequesne] (Upper arm)	0.383	0.616	0.000
M81.61 Localized osteoporosis [Lequesne] (Shoulder region)	0.383	0.616	0.000
M81.60 Localized osteoporosis [Lequesne] (Multiple sites)	0.383	0.616	0.000
M81.89 Other osteoporosis (Site unspecified)	0.383	0.616	0.000
M81.88 Other osteoporosis (Other)	0.383	0.616	0.000
M81.87 Other osteoporosis (Ankle and foot)	0.383	0.616	0.000
M81.86 Other osteoporosis (Lower leg)	0.383	0.616	0.000
M81.85 Other osteoporosis (Pelvic region and thigh)	0.383	0.616	0.000
M81.84 Other osteoporosis (Hand)	0.383	0.616	0.000
M81.83 Other osteoporosis (Forearm)	0.383	0.616	0.000
M81.82 Other osteoporosis (Upper arm)	0.383	0.616	0.000
M81.81 Other osteoporosis (Shoulder region)	0.383	0.616	0.000
M81.80 Other osteoporosis (Multiple sites)	0.383	0.616	0.000
M22.2 Patellofemoral disorders	0.382	0.618	0.000
M34.8 Other forms of systemic sclerosis	0.382	0.618	0.000
M24.5 Contracture of joint	0.380	0.620	0.000
M62.87 Other specified disorders of muscle (Ankle and foot)	0.380	0.620	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.380	0.620	0.000
M62.84 Other specified disorders of muscle (Hand)	0.380	0.620	0.000
M62.83 Other specified disorders of muscle (Forearm)	0.380	0.620	0.000
M62.82 Other specified disorders of muscle (Upper arm)	0.380	0.620	0.000
M62.81 Other specified disorders of muscle (Shoulder region)	0.380	0.620	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.379	0.620	0.000
M34.0 Progressive systemic sclerosis	0.379	0.620	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.379	0.621	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.378	0.621	0.000
M65-M68 Disorders of synovium and tendon	0.378	0.622	0.001
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.377	0.623	0.000
M40 Kyphosis and lordosis	0.377	0.623	0.000
M91 Juvenile osteochondrosis of hip and pelvis	0.376	0.624	0.000
M62.54 Muscle wasting and atrophy, not elsewhere classified (Hand)	0.376	0.624	0.000
M85.19 Skeletal fluorosis (Site unspecified)	0.375	0.625	0.000
M85.18 Skeletal fluorosis (Other)	0.375	0.625	0.000
M85.17 Skeletal fluorosis (Ankle and foot)	0.375	0.625	0.000
M85.16 Skeletal fluorosis (Lower leg)	0.375	0.625	0.000
M85.15 Skeletal fluorosis (Pelvic region and thigh)	0.375	0.625	0.000
M85.14 Skeletal fluorosis (Hand)	0.375	0.625	0.000
M85.13 Skeletal fluorosis (Forearm)	0.375	0.625	0.000
M85.12 Skeletal fluorosis (Upper arm)	0.375	0.625	0.000
M85.11 Skeletal fluorosis (Shoulder region)	0.375	0.625	0.000
M85.10 Skeletal fluorosis (Multiple sites)	0.375	0.625	0.000
M85.29 Hyperostosis of skull-Site unspec	0.375	0.625	0.000
M85.28 Hyperostosis of skull-Other	0.375	0.625	0.000
M85.27 Hyperostosis of skull-Ankle/Foot	0.375	0.625	0.000
M85.26 Hyperostosis of skull-Lower Leg	0.375	0.625	0.000
M85.25 Hyperostosis of skull-Pelvic/Thigh	0.375	0.625	0.000
M85.24 Hyperostosis of skull-Hand	0.375	0.625	0.000
M85.23 Hyperostosis of skull-Forearm	0.375	0.625	0.000
M85.22 Hyperostosis of skull-Upper arm	0.375	0.625	0.000
M85.21 Hyperostosis of skull-Shldr region	0.375	0.625	0.000
M85.20 Hyperostosis of skull-Mult sites	0.375	0.625	0.000
M85.39 Osteitis condensans (Site unspecified)	0.375	0.625	0.000
M85.38 Osteitis condensans (Other)	0.375	0.625	0.000
M85.37 Osteitis condensans (Ankle and foot)	0.375	0.625	0.000
M85.36 Osteitis condensans (Lower leg)	0.375	0.625	0.000
M85.35 Osteitis condensans (Pelvic region and thigh)	0.375	0.625	0.000
M85.34 Osteitis condensans (Hand)	0.375	0.625	0.000
M85.33 Osteitis condensans (Forearm)	0.375	0.625	0.000
M85.32 Osteitis condensans (Upper arm)	0.375	0.625	0.000
M85.31 Osteitis condensans (Shoulder region)	0.375	0.625	0.000
M85.30 Osteitis condensans (Multiple sites)	0.375	0.625	0.000
M85.49 Solitary bone cyst (Site unspecified)	0.375	0.625	0.000
M85.48 Solitary bone cyst (Other)	0.375	0.625	0.000
M85.47 Solitary bone cyst (Ankle and foot)	0.375	0.625	0.000
M85.46 Solitary bone cyst (Lower leg)	0.375	0.625	0.000
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.375	0.625	0.000
M85.44 Solitary bone cyst (Hand)	0.375	0.625	0.000
M85.43 Solitary bone cyst (Forearm)	0.375	0.625	0.000
M85.42 Solitary bone cyst (Upper arm)	0.375	0.625	0.000
M85.41 Solitary bone cyst (Shoulder region)	0.375	0.625	0.000
M85.40 Solitary bone cyst (Multiple sites)	0.375	0.625	0.000
M85.59 Aneurysmal bone cyst (Site unspecified)	0.375	0.625	0.000
M85.58 Aneurysmal bone cyst (Other)	0.375	0.625	0.000
M85.57 Aneurysmal bone cyst (Ankle and foot)	0.375	0.625	0.000
M85.56 Aneurysmal bone cyst (Lower leg)	0.375	0.625	0.000
M85.55 Aneurysmal bone cyst (Pelvic region and thigh)	0.375	0.625	0.000
M85.54 Aneurysmal bone cyst (Hand)	0.375	0.625	0.000
M85.53 Aneurysmal bone cyst (Forearm)	0.375	0.625	0.000
M85.52 Aneurysmal bone cyst (Upper arm)	0.375	0.625	0.000
M85.51 Aneurysmal bone cyst (Shoulder region)	0.375	0.625	0.000
M85.50 Aneurysmal bone cyst (Multiple sites)	0.375	0.625	0.000
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.375	0.625	0.000
M85.98 Disorder of bone density and structure, unspecified (Other)	0.375	0.625	0.000
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.375	0.625	0.000
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.375	0.625	0.000
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.375	0.625	0.000
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.375	0.625	0.000
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.375	0.625	0.000
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.375	0.625	0.000
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.375	0.625	0.000
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.375	0.625	0.000
M12 Other specific arthropathies	0.374	0.626	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.374	0.626	0.000
M08 Juvenile arthritis	0.374	0.626	0.000
M81.29 Osteoporosis of disuse (Site unspecified)	0.374	0.626	0.000
M81.28 Osteoporosis of disuse (Other)	0.374	0.626	0.000
M81.27 Osteoporosis of disuse (Ankle and foot)	0.374	0.626	0.000
M81.26 Osteoporosis of disuse (Lower leg)	0.374	0.626	0.000
M81.25 Osteoporosis of disuse (Pelvic region and thigh)	0.374	0.626	0.000
M81.24 Osteoporosis of disuse (Hand)	0.374	0.626	0.000
M81.23 Osteoporosis of disuse (Forearm)	0.374	0.626	0.000
M81.22 Osteoporosis of disuse (Upper arm)	0.374	0.626	0.000
M81.21 Osteoporosis of disuse (Shoulder region)	0.374	0.626	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.373	0.627	0.000
M54.15 Radiculopathy (Thoracolumbar region)	0.373	0.627	0.000
M54.14 Radiculopathy (Thoracic region)	0.373	0.627	0.000
M54.13 Radiculopathy (Cervicothoracic region)	0.373	0.627	0.000
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.373	0.627	0.000
M54.10 Radiculopathy (Multiple sites in spine)	0.373	0.627	0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.373	0.627	0.000
M54.69 Pain in thoracic spine-Site unspe	0.372	0.628	0.000
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.372	0.628	0.000
M54.67 Pain in thoracic spine-Lumbosacral	0.372	0.628	0.000
M54.66 Pain in thoracic spine-Lumbar	0.372	0.628	0.000
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.372	0.628	0.000
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.372	0.628	0.000
M54.62 Pain in thoracic spine-Cervical	0.372	0.628	0.000
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.372	0.628	0.000
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.372	0.628	0.000
M33.9 Dermatopolymyositis, unspecified	0.371	0.628	0.000
M33.0 Juvenile dermatomyositis	0.371	0.628	0.000
M21.9 Acquired deformity of limb, unspecified	0.371	0.629	0.000
M21.8 Other specified acquired deformities of limbs	0.371	0.629	0.000
M21.7 Unequal limb length (acquired)	0.371	0.629	0.000
M42 Spinal osteochondrosis	0.371	0.629	0.000
M54.89 Other dorsalgia (Site unspecified)	0.370	0.630	0.000
M87.85 Other osteonecrosis (Pelvic region and thigh)	0.369	0.630	0.000
M54.17 Radiculopathy (Lumbosacral region)	0.369	0.631	0.000
M89.03 Algoneurodystrophy (Forearm)	0.368	0.632	0.000
M25.91 Joint disorder, unspecified (Shoulder region)	0.368	0.632	0.000
M62.89 Other specified disorders of muscle (Site unspecified)	0.367	0.633	0.000
M87.29 Osteonecrosis due to previous trauma (Site unspecified)	0.364	0.636	0.000
M87.28 Osteonecrosis due to previous trauma (Other)	0.364	0.636	0.000
M87.27 Osteonecrosis due to previous trauma (Ankle and foot)	0.364	0.636	0.000
M87.26 Osteonecrosis due to previous trauma (Lower leg)	0.364	0.636	0.000
M87.25 Osteonecrosis due to previous trauma (Pelvic region and thigh)	0.364	0.636	0.000
M87.24 Osteonecrosis due to previous trauma (Hand)	0.364	0.636	0.000
M87.23 Osteonecrosis due to previous trauma (Forearm)	0.364	0.636	0.000
M87.22 Osteonecrosis due to previous trauma (Upper arm)	0.364	0.636	0.000
M87.21 Osteonecrosis due to previous trauma (Shoulder region)	0.364	0.636	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.364	0.636	0.000
M80.8 Other osteoporosis with pathological fracture	0.363	0.636	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.363	0.636	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.363	0.636	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.363	0.636	0.000
M07 Psoriatic and enteropathic arthropathies	0.363	0.636	0.000
M93 Other osteochondropathies	0.363	0.637	0.000
M54.2 Cervicalgia	0.363	0.637	0.000
M86.9 Osteomyelitis, unspecified	0.362	0.638	0.000
M81.20 Osteoporosis of disuse (Multiple sites)	0.361	0.639	0.000
M87.97 Osteonecrosis, unspecified (Ankle and foot)	0.360	0.640	0.000
M60.9 Myositis, unspecified	0.360	0.640	0.000
M89.96 Disorder of bone, unspecified (Lower leg)	0.360	0.640	0.000
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.359	0.641	0.000
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.359	0.641	0.000
M31 Other necrotising vasculopathies	0.358	0.642	0.001

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations