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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1077393
log Bayes Factor = 141.29
Chromosome 6   position 31,610,529  (GRCh37) Explore rs1077393 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.000 1.000
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.001 0.999
I10 Essential (primary) hypertension
0.999 0.001 0.000
E10.2 With renal complications
0.000 0.004 0.996
E10.1 With ketoacidosis
0.000 0.006 0.994
K90 Intestinal malabsorption
0.000 0.015 0.985
E50-E64 Other nutritional deficiencies
0.000 0.025 0.975
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.025 0.975
K90.9 Intestinal malabsorption, unspecified
0.000 0.029 0.971
E14 Unspecified diabetes mellitus
0.000 0.035 0.965
E16 Other disorders of pancreatic internal secretion
0.000 0.043 0.957
E10.4 With neurological complications
0.000 0.054 0.946
E53 Deficiency of other B group vitamins
0.000 0.068 0.932
E16.2 Hypoglycaemia, unspecified
0.000 0.069 0.931
E10.5 With peripheral circulatory complications
0.000 0.083 0.917
L40.9 Psoriasis, unspecified
0.909 0.091 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.098 0.902
E14.3 With ophthalmic complications
0.000 0.105 0.895
E55 Vitamin D deficiency
0.000 0.112 0.888
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.124 0.876
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.128 0.872
E10.0 With coma
0.000 0.131 0.869
E06 Thyroiditis
0.000 0.135 0.865
G37 Other demyelinating diseases of central nervous system
0.000 0.153 0.847
E53.8 Deficiency of other specified B group vitamins
0.000 0.156 0.844
E53.9 Vitamin B deficiency, unspecified
0.000 0.160 0.840
E14.6 With other specified complications
0.000 0.165 0.835
E55.9 Vitamin D deficiency, unspecified
0.000 0.174 0.826
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.177 0.823
T36-T50 Poisoning by drugs, medicaments and biological substances
0.786 0.214 0.000
E14.2 Withrenal complications
0.000 0.220 0.780
K90.8 Other intestinal malabsorption
0.000 0.229 0.771
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.769 0.231 0.000
E14.8 With unspecified complications
0.000 0.231 0.769
E14.1 With ketoacidosis
0.000 0.231 0.769
G37.8 Other specified demyelinating diseases of central nervous system
0.000 0.232 0.768
T39.1 4-Aminophenol derivatives
0.766 0.234 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.765 0.235 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.760 0.240 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.757 0.243 0.000
E14.5 With peripheral circulatory complications
0.000 0.245 0.755
R31 Unspecified haematuria
0.754 0.246 0.000
G37.9 Demyelinating disease of central nervous system, unspecified
0.000 0.248 0.752
E06.9 Thyroiditis, unspecified
0.000 0.253 0.747
E13 Other specified diabetes mellitus
0.000 0.253 0.747
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.742 0.258 0.000
E10.7 With multiple complications
0.000 0.259 0.741
E40-E46 Malnutrition
0.000 0.267 0.732
E51 Thiamine deficiency
0.000 0.270 0.730
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.728 0.272 0.000
E05.5 Thyroid crisis or storm
0.000 0.283 0.717
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.717
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.717
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E58 Dietary calcium deficiency
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.716
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.716
E10.6 With other specified complications
0.000 0.289 0.711
K90.3 Pancreatic steatorrhoea
0.000 0.294 0.706
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.294 0.706
K90.1 Tropical sprue
0.000 0.294 0.706
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.000 0.296 0.704
E06.3 Autoimmune thyroiditis
0.000 0.296 0.704
E14.4 With neurological complications
0.000 0.299 0.701
E05.8 Other thyrotoxicosis
0.000 0.300 0.700
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.301 0.699
E63 Other nutritional deficiencies
0.000 0.301 0.699
E50 Vitamin A deficiency
0.000 0.301 0.699
E60 Dietary zinc deficiency
0.000 0.301 0.699
E59 Dietary selenium deficiency
0.000 0.301 0.699
E52 Niacin deficiency [pellagra]
0.000 0.301 0.699
E15 Nondiabetic hypoglycaemic coma
0.000 0.301 0.699
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.698 0.302 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.693 0.307 0.000
E14.7 With multiple complications
0.000 0.308 0.692
E14.0 With coma
0.000 0.308 0.692
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.314 0.686
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.314 0.686
E16.4 Abnormal secretion of gastrin
0.000 0.314 0.686
E16.3 Increased secretion of glucagon
0.000 0.314 0.686
E61 Deficiency of other nutrient elements
0.000 0.314 0.686
T43.2 Other and unspecified antidepressants
0.677 0.323 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.670 0.330 0.000
E53.1 Pyridoxine deficiency
0.000 0.331 0.669
E53.0 Riboflavin deficiency
0.000 0.331 0.669
T50.9 Other and unspecified drugs, medicaments and biological substances
0.667 0.333 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.666 0.334 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.656 0.344 0.000
E54 Ascorbic acid deficiency
0.000 0.355 0.645
T39.0 Salicylates
0.638 0.362 0.000
E56 Other vitamin deficiencies
0.000 0.362 0.637
E55.0 Rickets, active
0.000 0.363 0.637
T43.3 Phenothiazine antipsychotics and neuroleptics
0.632 0.368 0.000
G36 Other acute disseminated demyelination
0.000 0.379 0.621
E06.4 Drug-induced thyroiditis
0.000 0.380 0.620
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.380 0.620
E06.0 Acute thyroiditis
0.000 0.380 0.620
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.619 0.381 0.000
E06.5 Other chronic thyroiditis
0.000 0.388 0.612
R04.0 Epistaxis
0.611 0.389 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.610 0.390 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.609 0.390 0.000
G37.5 Concentric sclerosis [Balo]
0.000 0.393 0.607
G37.4 Subacute necrotising myelitis
0.000 0.393 0.607
G37.2 Central pontine myelinolysis
0.000 0.393 0.607
G37.1 Central demyelination of corpus callosum
0.000 0.393 0.607
G37.0 Diffuse sclerosis
0.000 0.393 0.607
E10.8 With unspecified complications
0.000 0.396 0.604
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.411 0.589
E13.9 Without complications
0.000 0.416 0.584
L40 Psoriasis
0.579 0.421 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.576 0.424 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.576 0.424 0.000
T45.0 Antiallergic and antiemetic drugs
0.574 0.426 0.000
T43.6 Psychostimulants with abuse potential
0.574 0.426 0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.574 0.426 0.000
E61.2 Magnesium deficiency
0.000 0.427 0.573
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.571 0.428 0.000
E06.1 Subacute thyroiditis
0.000 0.430 0.570
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.569 0.431 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.569 0.431 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.569 0.431 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.566 0.434 0.000
T50.4 Drugs affecting uric acid metabolism
0.565 0.435 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.564 0.436 0.000
E51.2 Wernicke's encephalopathy
0.000 0.447 0.553
T39.4 Antirheumatics, not elsewhere classified
0.552 0.448 0.000
T39.2 Pyrazolone derivatives
0.552 0.448 0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.549 0.451 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.549 0.451 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.549 0.451 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.549 0.451 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.549 0.451 0.000
T44.0 Anticholinesterase agents
0.549 0.451 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.548 0.452 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.545 0.455 0.000
T46.7 Peripheral vasodilators
0.545 0.455 0.000
T43.9 Psychotropic drug, unspecified
0.543 0.457 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.543 0.457 0.000
E46 Unspecified protein-energy malnutrition
0.000 0.459 0.541
E13.8 With unspecified complications
0.000 0.464 0.536
E13.7 With multiple complications
0.000 0.464 0.536
E13.6 With other specified complications
0.000 0.464 0.536
E13.5 With peripheral circulatory complications
0.000 0.464 0.536
E13.4 With neurological complications
0.000 0.464 0.536
E13.2 With renal complications
0.000 0.464 0.536
E13.1 With ketoacidosis
0.000 0.464 0.536
E13.0 With coma
0.000 0.464 0.536
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.534 0.466 0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.533 0.467 0.000
E78.0 Pure hypercholesterolaemia
0.528 0.472 0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.528 0.472 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.475 0.525
E45 Retarded development following protein-energy malnutrition
0.000 0.475 0.525
E43 Unspecified severe protein-energy malnutrition
0.000 0.475 0.525
E42 Marasmic kwashiorkor
0.000 0.475 0.525
E41 Nutritional marasmus
0.000 0.475 0.525
E40 Kwashiorkor
0.000 0.475 0.525
E51.9 Thiamine deficiency, unspecified
0.000 0.477 0.523
E51.8 Other manifestations of thiamine deficiency
0.000 0.477 0.523
E51.1 Beriberi
0.000 0.477 0.523
T50.7 Analeptics and opioid receptor antagonists
0.522 0.478 0.000
T50.5 Appetite depressants
0.522 0.478 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.522 0.478 0.000
T50.1 Loop [high-ceiling] diuretics
0.522 0.478 0.000
T50.0 Mineralocorticoids and their antagonists
0.522 0.478 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.520 0.479 0.000
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E13.3 With ophthalmic complications
0.000 0.487 0.513
E16.1 Other hypoglycaemia
0.000 0.490 0.510
T36 Poisoning by systemic antibiotics
0.509 0.491 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.508 0.492 0.000
E50.9 Vitamin A deficiency, unspecified
0.000 0.498 0.501
E50.8 Other manifestations of vitamin A deficiency
0.000 0.498 0.501
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.498 0.501
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.498 0.501
E50.5 Vitamin A deficiency with night blindness
0.000 0.498 0.501
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.498 0.501
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.498 0.501
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.498 0.501
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.498 0.501
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.498 0.501
E63.9 Nutritional deficiency, unspecified
0.000 0.498 0.501
E63.8 Other specified nutritional deficiencies
0.000 0.498 0.501
E63.1 Imbalance of constituents of food intake
0.000 0.498 0.501
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.498 0.501
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.498 0.501
E64.8 Sequelae of other nutritional deficiencies
0.000 0.498 0.501
E64.3 Sequelae of rickets
0.000 0.498 0.501
E64.2 Sequelae of vitamin C deficiency
0.000 0.498 0.501
E64.1 Sequelae of vitamin A deficiency
0.000 0.498 0.501
E64.0 Sequelae of protein-energy malnutrition
0.000 0.498 0.501
T38.8 Other and unspecified hormones and their synthetic substitutes
0.495 0.505 0.000
E61.9 Deficiency of nutrient element, unspecified
0.000 0.508 0.492
E61.8 Deficiency of other specified nutrient elements
0.000 0.508 0.492
E61.7 Deficiency of multiple nutrient elements
0.000 0.508 0.492
E61.6 Vanadium deficiency
0.000 0.508 0.492
E61.5 Molybdenum deficiency
0.000 0.508 0.492
E61.4 Chromium deficiency
0.000 0.508 0.492
E61.3 Manganese deficiency
0.000 0.508 0.492
E61.0 Copper deficiency
0.000 0.508 0.492
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.487 0.512 0.000
L40.8 Other psoriasis
0.483 0.517 0.000
T38.1 Thyroid hormones and substitutes
0.481 0.519 0.000
T45.5 Anticoagulants
0.479 0.520 0.000
T38.0 Glucocorticoids and synthetic analogues
0.478 0.522 0.000
T38.9 Other and unspecified hormone antagonists
0.477 0.522 0.000
T38.7 Androgens and anabolic congeners
0.477 0.522 0.000
T38.5 Other oestrogens and progestogens
0.477 0.522 0.000
T38.4 Oral contraceptives
0.477 0.522 0.000
T38.2 Antithyroid drugs
0.477 0.522 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.522 0.478
T46.1 Calcium-channel blockers
0.470 0.530 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.470 0.530 0.000
T45.8 Other primarily systemic and haematological agents
0.470 0.530 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.470 0.530 0.000
T45.6 Fibrinolysis-affecting drugs
0.470 0.530 0.000
T45.4 Iron and its compounds
0.470 0.530 0.000
T45.3 Enzymes, not elsewhere classified
0.470 0.530 0.000
L40.5 Arthropathic psoriasis
0.467 0.533 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.462 0.538 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.459 0.541 0.000
T50.8 Diagnostic agents
0.459 0.541 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.459 0.541 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.458 0.542 0.000
E56.9 Vitamin deficiency, unspecified
0.000 0.543 0.457
E56.8 Deficiency of other vitamins
0.000 0.543 0.457
E56.0 Deficiency of vitamin E
0.000 0.543 0.457
L40.0 Psoriasis vulgaris
0.455 0.545 0.000
T37.2 Antimalarials and drugs acting on other blood protozoa
0.448 0.551 0.000
E11 Non-insulin-dependent diabetes mellitus
0.000 0.554 0.446
G36.9 Acute disseminated demyelination, unspecified
0.000 0.554 0.445
G36.8 Other specified acute disseminated demyelination
0.000 0.554 0.445
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.000 0.554 0.445
T43.0 Tricyclic and tetracyclic antidepressants
0.443 0.557 0.000
G36.0 Neuromyelitis optica [Devic]
0.000 0.558 0.442
T45.2 Vitamins, not elsewhere classified
0.441 0.559 0.000
E27 Other disorders of adrenal gland
0.000 0.567 0.433
E20-E35 Disorders of other endocrine glands
0.000 0.567 0.432
T47.2 Stimulant laxatives
0.432 0.568 0.000
L40.4 Guttate psoriasis
0.419 0.581 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.416 0.584 0.000
L40.2 Acrodermatitis continua
0.415 0.585 0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.413 0.587 0.000
T47.8 Other agents primarily affecting the gastro-intestinal system
0.413 0.587 0.000
T47.7 Emetics
0.413 0.587 0.000
T47.5 Digestants
0.413 0.587 0.000
T47.3 Saline and osmotic laxatives
0.413 0.587 0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.413 0.587 0.000
T37.5 Antiviral drugs
0.413 0.587 0.000
T37.4 Anthelminthics
0.413 0.587 0.000
T37.3 Other antiprotozoal drugs
0.413 0.587 0.000
T37.1 Antimycobacterial drugs
0.413 0.587 0.000
T37.0 Sulphonamides
0.413 0.587 0.000
E07 Other disorders of thyroid
0.000 0.590 0.410
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.408 0.592 0.000
T49.9 Topical agent, unspecified
0.406 0.594 0.000
T49.8 Other topical agents
0.406 0.594 0.000
T49.7 Dental drugs, topically applied
0.406 0.594 0.000
T49.6 Otorhinolaryngological drugs and preparations
0.406 0.594 0.000
T49.5 Ophthalmological drugs and preparations
0.406 0.594 0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.406 0.594 0.000
T49.3 Emollients, demulcents and protectants
0.406 0.594 0.000
T49.2 Local astringents and local detergents
0.406 0.594 0.000
T49.1 Antipruritics
0.406 0.594 0.000
T41.5 Therapeutic gases
0.404 0.596 0.000
T41.4 Anaesthetic, unspecified
0.404 0.596 0.000
T41.3 Local anaesthetics
0.404 0.596 0.000
T41.2 Other and unspecified general anaesthetics
0.404 0.596 0.000
T41.1 Intravenous anaesthetics
0.404 0.596 0.000
T41.0 Inhaled anaesthetics
0.404 0.596 0.000
E11.5 With peripheral circulatory complications
0.000 0.597 0.403
T47.4 Other laxatives
0.398 0.602 0.000
T47.0 Histamine H(2)-receptor antagonists
0.397 0.603 0.000
T42.0 Hydantoin derivatives
0.396 0.604 0.000
E56.1 Deficiency of vitamin K
0.000 0.605 0.395
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.394 0.605 0.000
T42.3 Barbiturates
0.394 0.605 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.384 0.616 0.000
T37.8 Other specified systemic anti-infectives and antiparasitics
0.382 0.618 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.382 0.618 0.000
D25.9 Leiomyoma of uterus, unspecified
0.381 0.619 0.000
T47.6 Antidiarrhoeal drugs
0.380 0.620 0.000
E44.1 Mild protein-energy malnutrition
0.000 0.623 0.377
E44.0 Moderate protein-energy malnutrition
0.000 0.623 0.377
T42.1 Iminostilbenes
0.374 0.626 0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.373 0.627 0.000
T48.4 Expectorants
0.373 0.627 0.000
T48.3 Antitussives
0.373 0.627 0.000
T48.2 Other and unspecified agents primarily acting on muscles
0.373 0.627 0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.373 0.627 0.000
T48.0 Oxytocic drugs
0.373 0.627 0.000
E11.4 With neurological complications
0.000 0.628 0.372
T36.9 Systemic antibiotic, unspecified
0.365 0.635 0.000
T36.8 Other systemic antibiotics
0.365 0.635 0.000
T36.7 Antifungal antibiotics, systemically used
0.365 0.635 0.000
T36.6 Rifamycins
0.365 0.635 0.000
T36.5 Aminoglycosides
0.365 0.635 0.000
T36.3 Macrolides
0.365 0.635 0.000
T36.2 Chloramphenicol group
0.365 0.635 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.364 0.636 0.000
T42.2 Succinimides and oxazolidinediones
0.364 0.636 0.000
T48.5 Anti-common-cold drugs
0.360 0.640 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.646 0.353
L40.1 Generalised pustular psoriasis
0.351 0.649 0.000
L40.3 Pustulosis palmaris et plantaris
0.349 0.651 0.000
T48.6 Antiasthmatics, not elsewhere classified
0.346 0.654 0.000
E11.0 With coma
0.000 0.660 0.339
T36.4 Tetracyclines
0.337 0.663 0.000
E11.1 With ketoacidosis
0.000 0.665 0.334
E20 Hypoparathyroidism
0.000 0.670 0.330
E61.1 Iron deficiency
0.000 0.672 0.328
E31 Polyglandular dysfunction
0.000 0.681 0.319
E24 Cushing's syndrome
0.000 0.683 0.317
E11.7 With multiple complications
0.000 0.687 0.313
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.311 0.689 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.690 0.310
E27.0 Other adrenocortical overactivity
0.000 0.690 0.310
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.690 0.310
E32 Diseases of thymus
0.000 0.690 0.310
E30 Disorders of puberty, not elsewhere classified
0.000 0.690 0.310
E11.6 With other specified complications
0.000 0.691 0.309
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.306 0.694 0.000
E11.8 With unspecified complications
0.000 0.695 0.305
K52.8 Other specified non-infective gastro-enteritis and colitis
0.000 0.695 0.305
E27.2 Addisonian crisis
0.000 0.696 0.304
T42.4 Benzodiazepines
0.303 0.697 0.000
E25 Adrenogenital disorders
0.000 0.701 0.299
T36.0 Penicillins
0.298 0.702 0.000
E07.1 Dyshormogenetic goitre
0.000 0.706 0.294
E07.0 Hypersecretion of calcitonin
0.000 0.706 0.294
M35.0 Sicca syndrome [Sjogren]
0.000 0.714 0.286
E34 Other endocrine disorders
0.000 0.729 0.271
E24.0 Pituitary-dependent Cushing's disease
0.000 0.739 0.261
E20.9 Hypoparathyroidism, unspecified
0.000 0.743 0.257
E27.9 Disorder of adrenal gland, unspecified
0.000 0.743 0.256
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.254 0.746 0.000
E67 Other hyperalimentation
0.000 0.746 0.253
E68 Sequelae of hyperalimentation
0.000 0.746 0.253
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.754 0.246
E31.0 Autoimmune polyglandular failure
0.000 0.763 0.237
E20.8 Other hypoparathyroidism
0.000 0.763 0.237
E20.1 Pseudohypoparathyroidism
0.000 0.763 0.237
E20.0 Idiopathic hypoparathyroidism
0.000 0.763 0.237
E07.8 Other specified disorders of thyroid
0.000 0.764 0.236
E24.9 Cushing's syndrome, unspecified
0.000 0.767 0.233
E31.9 Polyglandular dysfunction, unspecified
0.000 0.771 0.228
E31.8 Other polyglandular dysfunction
0.000 0.771 0.228
E31.1 Polyglandular hyperfunction
0.000 0.771 0.228
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.772 0.227
E24.3 Ectopic ACTH syndrome
0.000 0.772 0.227
E24.1 Nelson's syndrome
0.000 0.772 0.227
E30.9 Disorder of puberty, unspecified
0.000 0.777 0.222
E30.8 Other disorders of puberty
0.000 0.777 0.222
E30.1 Precocious puberty
0.000 0.777 0.222
E30.0 Delayed puberty
0.000 0.777 0.222
E32.9 Disease of thymus, unspecified
0.000 0.777 0.222
E32.8 Other diseases of thymus
0.000 0.777 0.222
E32.1 Abscess of thymus
0.000 0.777 0.222
E32.0 Persistent hyperplasia of thymus
0.000 0.777 0.222
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.777 0.222
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.777 0.222
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.777 0.222
E24.8 Other Cushing's syndrome
0.000 0.779 0.220
E04 Other non-toxic goitre
0.000 0.781 0.219
E34.8 Other specified endocrine disorders
0.000 0.785 0.215
E25.9 Adrenogenital disorder, unspecified
0.000 0.785 0.214
E25.8 Other adrenogenital disorders
0.000 0.785 0.214
I26.9 Pulmonary embolism without mention of acute cor pulmonale
0.000 0.790 0.210
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.797 0.203
N04.9 Unspecified
0.000 0.797 0.203
F41.9 Anxiety disorder, unspecified
0.203 0.797 0.000
E27.8 Other specified disorders of adrenal gland
0.000 0.801 0.198
T40.5 Cocaine
0.197 0.803 0.000
E03 Other hypothyroidism
0.000 0.803 0.196
N04 Nephrotic syndrome
0.000 0.805 0.195
E27.3 Drug-induced adrenocortical insufficiency
0.001 0.805 0.194
E34.5 Androgen resistance syndrome
0.000 0.806 0.194
E34.4 Constitutional tall stature
0.000 0.806 0.194
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.806 0.194
E34.1 Other hypersecretion of intestinal hormones
0.000 0.806 0.194
E11.2 With renal complications
0.000 0.807 0.193
E28 Ovarian dysfunction
0.000 0.808 0.192
E29 Testicular dysfunction
0.001 0.810 0.189
E24.2 Drug-induced Cushing's syndrome
0.000 0.813 0.187
E34.9 Endocrine disorder, unspecified
0.000 0.815 0.185
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.182 0.818 0.000
T40.8 Lysergide [LSD]
0.182 0.818 0.000
T40.7 Cannabis (derivatives)
0.182 0.818 0.000
T40.3 Methadone
0.182 0.818 0.000
T40.0 Opium
0.182 0.818 0.000
E67.8 Other specified hyperalimentation
0.000 0.818 0.182
E67.3 Hypervitaminosis D
0.000 0.818 0.182
E67.2 Megavitamin-B6 syndrome
0.000 0.818 0.182
E67.1 Hypercarotenaemia
0.000 0.818 0.182
E67.0 Hypervitaminosis A
0.000 0.818 0.182
R04 Haemorrhage from respiratory passages
0.182 0.818 0.000
N00-N08 Glomerular diseases
0.000 0.820 0.180
N08 Glomerular disorders in diseases classified elsewhere
0.000 0.820 0.180
E26 Hyperaldosteronism
0.001 0.820 0.178
E34.0 Carcinoid syndrome
0.000 0.821 0.179
T40.1 Heroin
0.176 0.824 0.000
F41 Other anxiety disorders
0.172 0.828 0.000
N08.3 Glomerular disorders in diabetes mellitus
0.000 0.828 0.172
N08.5 Glomerular disorders in systemic connective tissue disorders
0.000 0.830 0.170
L40-L45 Papulosquamous disorders
0.164 0.830 0.006
F41.2 Mixed anxiety and depressive disorder
0.167 0.833 0.000
E04.0 Non-toxic diffuse goitre
0.000 0.834 0.166
E14.9 Without complications
0.000 0.835 0.165
N04.1 Focal and segmental glomerular lesions
0.000 0.837 0.163
E22 Hyperfunction of pituitary gland
0.000 0.839 0.160
E11.3 With ophthalmic complications
0.000 0.840 0.160
N04.2 Diffuse membranous glomerulonephritis
0.000 0.841 0.159
N05 Unspecified nephritic syndrome
0.000 0.841 0.159
E04.8 Other specified non-toxic goitre
0.000 0.843 0.157
E34.3 Short stature, not elsewhere classified
0.000 0.846 0.154
E66 Obesity
0.000 0.846 0.154
N05.2 Diffuse membranous glomerulonephritis
0.000 0.850 0.150
T40.6 Other and unspecified narcotics
0.146 0.853 0.000
R04.8 Haemorrhage from other sites in respiratory passages
0.146 0.854 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.859 0.141
E03.5 Myxoedema coma
0.000 0.859 0.141
E03.4 Atrophy of thyroid (acquired)
0.000 0.859 0.141
E03.3 Postinfectious hypothyroidism
0.000 0.859 0.141
N04.8 Other
0.000 0.860 0.140
N04.7 Diffuse crescentic glomerulonephritis
0.000 0.860 0.140
N04.6 Dense deposit disease
0.000 0.860 0.140
N04.5 Diffuse mesangiocapillary glomerulonephritis
0.000 0.860 0.140
N04.4 Diffuse endocapillary proliferative glomerulonephritis
0.000 0.860 0.140
N04.3 Diffuse mesangial proliferative glomerulonephritis
0.000 0.860 0.140
E28.9 Ovarian dysfunction, unspecified
0.000 0.862 0.138
E28.8 Other ovarian dysfunction
0.000 0.862 0.138
E28.1 Androgen excess
0.000 0.862 0.138
E28.0 Oestrogen excess
0.000 0.862 0.138
E66.8 Other obesity
0.000 0.863 0.137
F40-F48 Neurotic, stress-related and somatoform disorders
0.137 0.863 0.000
I10-I15 Hypertensive diseases
0.137 0.863 0.000
E29.8 Other testicular dysfunction
0.001 0.864 0.136
E29.0 Testicular hyperfunction
0.001 0.864 0.136
R04.1 Haemorrhage from throat
0.136 0.864 0.000
E03.1 Congenital hypothyroidism without goitre
0.000 0.865 0.135
N04.0 Minor glomerular abnormality
0.000 0.867 0.133
N05.1 Focal and segmental glomerular lesions
0.000 0.869 0.131
R04.9 Haemorrhage from respiratory passages, unspecified
0.130 0.870 0.000
F43.0 Acute stress reaction
0.129 0.871 0.000
N07 Hereditary nephropathy, not elsewhere classified
0.000 0.871 0.129
N06 Isolated proteinuria with specified morphological lesion
0.000 0.871 0.129
N01 Rapidly progressive nephritic syndrome
0.000 0.871 0.129
N00 Acute nephritic syndrome
0.000 0.871 0.129
N08.8 Glomerular disorders in other diseases classified elsewhere
0.000 0.871 0.129
N08.1 Glomerular disorders in neoplastic diseases
0.000 0.871 0.129
N08.0 Glomerular disorders in infectious and parasitic diseases classified elsewhere
0.000 0.871 0.129
F40 Phobic anxiety disorders
0.129 0.871 0.000
E26.8 Other hyperaldosteronism
0.001 0.871 0.128
E26.1 Secondary hyperaldosteronism
0.001 0.871 0.128
F43 Reaction to severe stress, and adjustment disorders
0.129 0.871 0.000
L41 Parapsoriasis
0.125 0.871 0.004
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.872 0.128
N08.4 Glomerular disorders in other endocrine, nutritional and metabolic diseases
0.000 0.872 0.128
E07.9 Disorder of thyroid, unspecified
0.000 0.872 0.128
E29.9 Testicular dysfunction, unspecified
0.001 0.873 0.126
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.875 0.125
T40.2 Other opioids
0.125 0.875 0.000
F40.2 Specific (isolated) phobias
0.123 0.877 0.000
L42 Pityriasis rosea
0.119 0.878 0.004
B37.8 Candidiasis of other sites
0.000 0.878 0.122
L44 Other papulosquamous disorders
0.118 0.878 0.004
E65 Localised adiposity
0.001 0.878 0.121
I26 Pulmonary embolism
0.000 0.878 0.122
L45 Papulosquamous disorders in diseases classified elsewhere
0.118 0.878 0.004
N08.2 Glomerular disorders in blood diseases and disorders involving the immune mechanism
0.000 0.879 0.120
E28.3 Primary ovarian failure
0.000 0.881 0.119
E04.1 Non-toxic single thyroid nodule
0.000 0.883 0.117

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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