TreeWAS – Variant ID: rs10889332

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.0 Pure hypercholesterolaemia	0.000	0.000	1.000
E78.5 Hyperlipidaemia, unspecified	0.000	0.000	1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.001	0.999
E78.1 Pure hyperglyceridaemia	0.000	0.170	0.830
E78.6 Lipoprotein deficiency	0.000	0.271	0.729
E78.3 Hyperchylomicronaemia	0.000	0.283	0.716
E78.8 Other disorders of lipoprotein metabolism	0.000	0.304	0.695
E78.4 Other hyperlipidaemia	0.000	0.369	0.631
E89.0 Postprocedural hypothyroidism	0.000	0.409	0.591
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.000	0.428	0.572
E70-E90 Metabolic disorders	0.000	0.430	0.570
E78.2 Mixed hyperlipidaemia	0.000	0.494	0.506
E80 Disorders of porphyrin and bilirubin metabolism	0.000	0.553	0.447
E79 Disorders of purine and pyrimidine metabolism	0.000	0.559	0.441
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.000	0.566	0.433
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.568	0.432
E84 Cystic fibrosis	0.000	0.582	0.418
E89.3 Postprocedural hypopituitarism	0.000	0.587	0.413
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.000	0.589	0.410
E89.8 Other postprocedural endocrine and metabolic disorders	0.000	0.589	0.410
E89.5 Postprocedural testicular hypofunction	0.000	0.589	0.410
E77 Disorders of glycoprotein metabolism	0.000	0.591	0.409
E76 Disorders of glycosaminoglycan metabolism	0.000	0.591	0.409
E72 Other disorders of amino-acid metabolism	0.000	0.591	0.409
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.000	0.591	0.409
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.000	0.591	0.409
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.000	0.605	0.395
E85 Amyloidosis	0.000	0.622	0.378
E89.1 Postprocedural hypoinsulinaemia	0.000	0.628	0.371
E87 Other disorders of fluid, electrolyte and acid-base balance	0.000	0.631	0.369
E87.6 Hypokalaemia	0.000	0.636	0.364
E89.2 Postprocedural hypoparathyroidism	0.000	0.641	0.359
E80.1 Porphyria cutanea tarda	0.000	0.650	0.350
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.000	0.651	0.349
E73 Lactose intolerance	0.000	0.654	0.346
E80.4 Gilbert's syndrome	0.000	0.656	0.344
E75.5 Other lipid storage disorders	0.000	0.664	0.336
E70 Disorders of aromatic amino-acid metabolism	0.000	0.668	0.332
E89.4 Postprocedural ovarian failure	0.000	0.675	0.325
E80.2 Other porphyria	0.000	0.679	0.321
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.000	0.679	0.321
E80.7 Disorder of bilirubin metabolism, unspecified	0.000	0.679	0.320
E80.5 Crigler-Najjar syndrome	0.000	0.679	0.320
E80.3 Defects of catalase and peroxydase	0.000	0.679	0.320
E80.0 Hereditary erythropoietic porphyria	0.000	0.679	0.320
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.000	0.683	0.316
E79.8 Other disorders of purine and pyrimidine metabolism	0.000	0.683	0.316
E79.1 Lesch-Nyhan syndrome	0.000	0.683	0.316
E75.6 Lipid storage disorder, unspecified	0.000	0.689	0.311
E75.4 Neuronal ceroid lipofuscinosis	0.000	0.689	0.311
E75.3 Sphingolipidosis, unspecified	0.000	0.689	0.311
E75.2 Other sphingolipidosis	0.000	0.689	0.311
E75.1 Other gangliosidosis	0.000	0.689	0.311
E75.0 GM2 gangliosidosis	0.000	0.689	0.311
E84.9 Cystic fibrosis, unspecified	0.000	0.691	0.309
E80.6 Other disorders of bilirubin metabolism	0.000	0.696	0.304
E84.8 Cystic fibrosis with other manifestations	0.000	0.700	0.300
E84.1 Cystic fibrosis with intestinal manifestations	0.000	0.700	0.300
E84.0 Cystic fibrosis with pulmonary manifestations	0.000	0.700	0.300
E87.5 Hyperkalaemia	0.000	0.703	0.297
E74 Other disorders of carbohydrate metabolism	0.000	0.704	0.295
E71.3 Disorders of fatty-acid metabolism	0.000	0.707	0.293
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.000	0.707	0.293
E71.1 Other disorders of branched-chain amino-acid metabolism	0.000	0.707	0.293
E71.0 Maple-syrup-urine disease	0.000	0.707	0.293
E72.9 Disorder of amino-acid metabolism, unspecified	0.000	0.707	0.293
E72.8 Other specified disorders of amino-acid metabolism	0.000	0.707	0.293
E72.5 Disorders of glycine metabolism	0.000	0.707	0.293
E72.4 Disorders of ornithine metabolism	0.000	0.707	0.293
E72.3 Disorders of lysine and hydroxylysine metabolism	0.000	0.707	0.293
E72.2 Disorders of urea cycle metabolism	0.000	0.707	0.293
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.000	0.707	0.293
E72.0 Disorders of amino-acid transport	0.000	0.707	0.293
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.000	0.707	0.293
E76.8 Other disorders of glucosaminoglycan metabolism	0.000	0.707	0.293
E76.3 Mucopolysaccharidosis, unspecified	0.000	0.707	0.293
E76.2 Other mucopolysaccharidoses	0.000	0.707	0.293
E76.1 Mucopolysaccharidosis, type II	0.000	0.707	0.293
E76.0 Mucopolysaccharidosis, type I	0.000	0.707	0.293
E77.9 Disorder of glycoprotein metabolism, unspecified	0.000	0.707	0.293
E77.8 Other disorders of glycoprotein metabolism	0.000	0.707	0.293
E77.1 Defects in glycoprotein degradation	0.000	0.707	0.293
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.000	0.707	0.293
E85.3 Secondary systemic amyloidosis	0.000	0.710	0.290
E88 Other metabolic disorders	0.000	0.717	0.283
E85.8 Other amyloidosis	0.000	0.729	0.271
E85.2 Heredofamilial amyloidosis, unspecified	0.000	0.729	0.271
E85.1 Neuropathic heredofamilial amyloidosis	0.000	0.729	0.271
E85.0 Nonneuropathic heredofamilial amyloidosis	0.000	0.729	0.271
E87.4 Mixed disorder of acid-base balance	0.000	0.735	0.265
E85.9 Amyloidosis, unspecified	0.000	0.742	0.257
E73.8 Other lactose intolerance	0.000	0.752	0.248
E73.1 Secondary lactase deficiency	0.000	0.752	0.248
E73.0 Congenital lactase deficiency	0.000	0.752	0.248
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.000	0.762	0.238
E70.8 Other disorders of aromatic amino-acid metabolism	0.000	0.762	0.238
E70.2 Disorders of tyrosine metabolism	0.000	0.762	0.238
E70.1 Other hyperphenylalaninaemias	0.000	0.762	0.238
E70.0 Classical phenylketonuria	0.000	0.762	0.238
E88.1 Lipodystrophy, not elsewhere classified	0.000	0.765	0.235
E85.4 Organ-limited amyloidosis	0.000	0.769	0.231
E74.9 Disorder of carbohydrate metabolism, unspecified	0.000	0.788	0.212
E74.8 Other specified disorders of carbohydrate metabolism	0.000	0.788	0.212
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.000	0.788	0.212
E74.2 Disorders of galactose metabolism	0.000	0.788	0.212
E74.1 Disorders of fructose metabolism	0.000	0.788	0.212
E88.3 Tumour lysis syndrome	0.000	0.798	0.202
E88.8 Other specified metabolic disorders	0.000	0.807	0.193
E88.9 Metabolic disorder, unspecified	0.000	0.807	0.193
E73.9 Lactose intolerance, unspecified	0.000	0.814	0.185
E87.0 Hyperosmolality and hypernatraemia	0.000	0.818	0.182
E74.0 Glycogen storage disease	0.001	0.832	0.167
E74.3 Other disorders of intestinal carbohydrate absorption	0.000	0.833	0.167
E87.3 Alkalosis	0.000	0.833	0.166
E70.3 Albinism	0.001	0.838	0.161
E87.7 Fluid overload	0.000	0.847	0.153
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.000	0.849	0.151
E83 Disorders of mineral metabolism	0.000	0.855	0.145
E88.2 Lipomatosis, not elsewhere classified	0.001	0.876	0.124
E10.3 With ophthalmic complications	0.000	0.888	0.112
E10 Insulin-dependent diabetes mellitus	0.000	0.892	0.108
E83.9 Disorder of mineral metabolism, unspecified	0.000	0.895	0.104
E83.8 Other disorders of mineral metabolism	0.000	0.895	0.104
E83.2 Disorders of zinc metabolism	0.000	0.895	0.104
E83.0 Disorders of copper metabolism	0.000	0.895	0.104
E83.4 Disorders of magnesium metabolism	0.000	0.896	0.104
E83.5 Disorders of calcium metabolism	0.000	0.899	0.101
E10.6 With other specified complications	0.000	0.901	0.099
E10.0 With coma	0.000	0.905	0.095
E10-E14 Diabetes mellitus	0.000	0.910	0.090
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.911	0.089
E10.9 Without complications	0.000	0.913	0.087
E10.1 With ketoacidosis	0.000	0.918	0.082
E10.4 With neurological complications	0.000	0.919	0.081
E10.7 With multiple complications	0.000	0.922	0.078
E10.5 With peripheral circulatory complications	0.000	0.925	0.075
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.933	0.067
E12 Malnutrition-related diabetes mellitus	0.000	0.935	0.065
E10.2 With renal complications	0.000	0.939	0.061
E13 Other specified diabetes mellitus	0.000	0.940	0.060
E10.8 With unspecified complications	0.000	0.942	0.058
E83.3 Disorders of phosphorus metabolism	0.000	0.945	0.055
E40-E46 Malnutrition	0.000	0.945	0.055
E87.1 Hypo-osmolality and hyponatraemia	0.000	0.946	0.054
E14 Unspecified diabetes mellitus	0.000	0.947	0.053
E16 Other disorders of pancreatic internal secretion	0.000	0.949	0.051
E87.2 Acidosis	0.000	0.950	0.050
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.952	0.048
E15 Nondiabetic hypoglycaemic coma	0.000	0.952	0.048
E12.9 Without complications	0.000	0.953	0.047
E12.8 With unspecified complications	0.000	0.953	0.047
E12.7 With multiple complications	0.000	0.953	0.047
E12.6 With other specified complications	0.000	0.953	0.047
E12.5 With peripheral circulatory complications	0.000	0.953	0.047
E12.4 With neurological complications	0.000	0.953	0.047
E12.3 With ophthalmic complications	0.000	0.953	0.047
E12.2 With renal complications	0.000	0.953	0.047
E12.1 With ketoacidosis	0.000	0.953	0.047
E12.0 With coma	0.000	0.953	0.047
E14.3 With ophthalmic complications	0.000	0.953	0.047
E13.3 With ophthalmic complications	0.000	0.956	0.044
E13.8 With unspecified complications	0.000	0.956	0.043
E13.7 With multiple complications	0.000	0.956	0.043
E13.6 With other specified complications	0.000	0.956	0.043
E13.5 With peripheral circulatory complications	0.000	0.956	0.043
E13.4 With neurological complications	0.000	0.956	0.043
E13.2 With renal complications	0.000	0.956	0.043
E13.1 With ketoacidosis	0.000	0.956	0.043
E13.0 With coma	0.000	0.956	0.043
E65-E68 Obesity and other hyperalimentation	0.000	0.958	0.042
E14.2 Withrenal complications	0.000	0.958	0.042
E86 Volume depletion	0.000	0.958	0.042
E14.6 With other specified complications	0.000	0.960	0.040
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.961	0.039
E45 Retarded development following protein-energy malnutrition	0.000	0.961	0.039
E43 Unspecified severe protein-energy malnutrition	0.000	0.961	0.039
E42 Marasmic kwashiorkor	0.000	0.961	0.039
E41 Nutritional marasmus	0.000	0.961	0.039
E40 Kwashiorkor	0.000	0.961	0.039
E13.9 Without complications	0.000	0.961	0.039
E14.7 With multiple complications	0.000	0.962	0.038
E14.0 With coma	0.000	0.962	0.038
E14.4 With neurological complications	0.000	0.963	0.037
E14.5 With peripheral circulatory complications	0.000	0.963	0.037
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.963	0.037
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.963	0.037
E16.4 Abnormal secretion of gastrin	0.000	0.963	0.037
E16.3 Increased secretion of glucagon	0.000	0.963	0.037
E14.8 With unspecified complications	0.000	0.964	0.036
E16.1 Other hypoglycaemia	0.000	0.965	0.035
M80.98 Unspecified osteoporosis with pathological fracture (Other)	0.035	0.965	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.034	0.966	0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)	0.032	0.968	0.000
E65 Localised adiposity	0.000	0.968	0.032
E67 Other hyperalimentation	0.000	0.969	0.031
E68 Sequelae of hyperalimentation	0.000	0.969	0.031
E46 Unspecified protein-energy malnutrition	0.000	0.970	0.030
E14.1 With ketoacidosis	0.000	0.971	0.029
E44.1 Mild protein-energy malnutrition	0.000	0.971	0.028
E44.0 Moderate protein-energy malnutrition	0.000	0.971	0.028
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.027	0.972	0.000
M80 Osteoporosis with pathological fracture	0.027	0.973	0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.027	0.973	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.027	0.973	0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)	0.025	0.975	0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)	0.025	0.975	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.025	0.975	0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)	0.025	0.975	0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)	0.025	0.975	0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)	0.025	0.975	0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)	0.025	0.975	0.000
E50-E64 Other nutritional deficiencies	0.000	0.976	0.024
M35.0 Sicca syndrome [Sjogren]	0.023	0.977	0.000
E67.8 Other specified hyperalimentation	0.000	0.978	0.022
E67.3 Hypervitaminosis D	0.000	0.978	0.022
E67.2 Megavitamin-B6 syndrome	0.000	0.978	0.022
E67.1 Hypercarotenaemia	0.000	0.978	0.022
E67.0 Hypervitaminosis A	0.000	0.978	0.022
E11 Non-insulin-dependent diabetes mellitus	0.000	0.979	0.021
M80.5 Idiopathic osteoporosis with pathological fracture	0.020	0.980	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.020	0.980	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.020	0.980	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.020	0.980	0.000
E83.1 Disorders of iron metabolism	0.000	0.981	0.019
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.019	0.981	0.000
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.019	0.981	0.000
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.019	0.981	0.000
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.019	0.981	0.000
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.019	0.981	0.000
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.019	0.981	0.000
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.019	0.981	0.000
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.019	0.981	0.000
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.019	0.981	0.000
E11.3 With ophthalmic complications	0.000	0.981	0.019
M80.8 Other osteoporosis with pathological fracture	0.019	0.981	0.000
E11.8 With unspecified complications	0.000	0.981	0.019
E56 Other vitamin deficiencies	0.000	0.981	0.018
G45.9 Transient cerebral ischaemic attack, unspecified	0.019	0.981	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.982	0.018
E50 Vitamin A deficiency	0.000	0.982	0.018
E60 Dietary zinc deficiency	0.000	0.982	0.018
E59 Dietary selenium deficiency	0.000	0.982	0.018
E54 Ascorbic acid deficiency	0.000	0.982	0.018
E52 Niacin deficiency [pellagra]	0.000	0.982	0.018
E63 Other nutritional deficiencies	0.000	0.983	0.017
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.017	0.983	0.000
E58 Dietary calcium deficiency	0.000	0.984	0.016
E11.7 With multiple complications	0.000	0.984	0.016
M80.81 Other osteoporosis with pathological fracture (Shoulder region)	0.015	0.985	0.000
C44.5 Skin of trunk	0.015	0.985	0.000
E51 Thiamine deficiency	0.000	0.985	0.015
E11.6 With other specified complications	0.000	0.985	0.015
M80.0 Postmenopausal osteoporosis with pathological fracture	0.015	0.985	0.000
E11.4 With neurological complications	0.000	0.985	0.015
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)	0.014	0.985	0.000
M80.58 Idiopathic osteoporosis with pathological fracture (Other)	0.014	0.985	0.000
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)	0.014	0.985	0.000
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)	0.014	0.985	0.000
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)	0.014	0.985	0.000
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)	0.014	0.985	0.000
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)	0.014	0.985	0.000
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)	0.014	0.985	0.000
M80.29 Osteoporosis of disuse with pathological fracture (Site unspecified)	0.014	0.986	0.000
M80.28 Osteoporosis of disuse with pathological fracture (Other)	0.014	0.986	0.000
M80.27 Osteoporosis of disuse with pathological fracture (Ankle and foot)	0.014	0.986	0.000
M80.26 Osteoporosis of disuse with pathological fracture (Lower leg)	0.014	0.986	0.000
M80.25 Osteoporosis of disuse with pathological fracture (Pelvic region and thigh)	0.014	0.986	0.000
M80.24 Osteoporosis of disuse with pathological fracture (Hand)	0.014	0.986	0.000
M80.23 Osteoporosis of disuse with pathological fracture (Forearm)	0.014	0.986	0.000
M80.22 Osteoporosis of disuse with pathological fracture (Upper arm)	0.014	0.986	0.000
M80.21 Osteoporosis of disuse with pathological fracture (Shoulder region)	0.014	0.986	0.000
M80.20 Osteoporosis of disuse with pathological fracture (Multiple sites)	0.014	0.986	0.000
M80.39 Postsurgical malabsorption osteoporosis with pathological fracture (Site unspecified)	0.014	0.986	0.000
M80.38 Postsurgical malabsorption osteoporosis with pathological fracture (Other)	0.014	0.986	0.000
M80.37 Postsurgical malabsorption osteoporosis with pathological fracture (Ankle and foot)	0.014	0.986	0.000
M80.36 Postsurgical malabsorption osteoporosis with pathological fracture (Lower leg)	0.014	0.986	0.000
M80.35 Postsurgical malabsorption osteoporosis with pathological fracture (Pelvic region and thigh)	0.014	0.986	0.000
M80.34 Postsurgical malabsorption osteoporosis with pathological fracture (Hand)	0.014	0.986	0.000
M80.33 Postsurgical malabsorption osteoporosis with pathological fracture (Forearm)	0.014	0.986	0.000
M80.32 Postsurgical malabsorption osteoporosis with pathological fracture (Upper arm)	0.014	0.986	0.000
M80.31 Postsurgical malabsorption osteoporosis with pathological fracture (Shoulder region)	0.014	0.986	0.000
M80.30 Postsurgical malabsorption osteoporosis with pathological fracture (Multiple sites)	0.014	0.986	0.000
M80.49 Drug-induced osteoporosis with pathological fracture (Site unspecified)	0.014	0.986	0.000
M80.48 Drug-induced osteoporosis with pathological fracture (Other)	0.014	0.986	0.000
M80.47 Drug-induced osteoporosis with pathological fracture (Ankle and foot)	0.014	0.986	0.000
M80.46 Drug-induced osteoporosis with pathological fracture (Lower leg)	0.014	0.986	0.000
M80.45 Drug-induced osteoporosis with pathological fracture (Pelvic region and thigh)	0.014	0.986	0.000
M80.44 Drug-induced osteoporosis with pathological fracture (Hand)	0.014	0.986	0.000
M80.43 Drug-induced osteoporosis with pathological fracture (Forearm)	0.014	0.986	0.000
M80.42 Drug-induced osteoporosis with pathological fracture (Upper arm)	0.014	0.986	0.000
M80.41 Drug-induced osteoporosis with pathological fracture (Shoulder region)	0.014	0.986	0.000
M80.40 Drug-induced osteoporosis with pathological fracture (Multiple sites)	0.014	0.986	0.000
E56.1 Deficiency of vitamin K	0.000	0.986	0.014
M80.89 Other osteoporosis with pathological fracture (Site unspecified)	0.014	0.986	0.000
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)	0.014	0.986	0.000
M80.86 Other osteoporosis with pathological fracture (Lower leg)	0.014	0.986	0.000
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)	0.014	0.986	0.000
M80.84 Other osteoporosis with pathological fracture (Hand)	0.014	0.986	0.000
M80.83 Other osteoporosis with pathological fracture (Forearm)	0.014	0.986	0.000
M80.82 Other osteoporosis with pathological fracture (Upper arm)	0.014	0.986	0.000
M80.80 Other osteoporosis with pathological fracture (Multiple sites)	0.014	0.986	0.000
E56.9 Vitamin deficiency, unspecified	0.000	0.986	0.013
E56.8 Deficiency of other vitamins	0.000	0.986	0.013
E56.0 Deficiency of vitamin E	0.000	0.986	0.013
E55 Vitamin D deficiency	0.000	0.986	0.014
M07.30 Other psoriatic arthropathies (Multiple sites)	0.013	0.987	0.000
E61 Deficiency of other nutrient elements	0.000	0.987	0.013
E50.9 Vitamin A deficiency, unspecified	0.000	0.987	0.013
E50.8 Other manifestations of vitamin A deficiency	0.000	0.987	0.013
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.987	0.013
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.987	0.013
E50.5 Vitamin A deficiency with night blindness	0.000	0.987	0.013
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.987	0.013
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.987	0.013
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.987	0.013
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.987	0.013
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.987	0.013
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.987	0.013
E64.8 Sequelae of other nutritional deficiencies	0.000	0.987	0.013
E64.3 Sequelae of rickets	0.000	0.987	0.013
E64.2 Sequelae of vitamin C deficiency	0.000	0.987	0.013
E64.1 Sequelae of vitamin A deficiency	0.000	0.987	0.013
E64.0 Sequelae of protein-energy malnutrition	0.000	0.987	0.013
E53 Deficiency of other B group vitamins	0.000	0.987	0.013
E63.8 Other specified nutritional deficiencies	0.000	0.987	0.012
E63.1 Imbalance of constituents of food intake	0.000	0.987	0.012
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.987	0.012
Q60.0 Renal agenesis, unilateral	0.012	0.988	0.000
M80-M85 Disorders of bone density and structure	0.012	0.988	0.000
E11.0 With coma	0.000	0.988	0.012
E63.9 Nutritional deficiency, unspecified	0.000	0.988	0.012
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)	0.011	0.988	0.000
M80.88 Other osteoporosis with pathological fracture (Other)	0.011	0.988	0.000
G43.9 Migraine, unspecified	0.012	0.988	0.000
E11.1 With ketoacidosis	0.000	0.989	0.011
E51.9 Thiamine deficiency, unspecified	0.000	0.989	0.011
E51.8 Other manifestations of thiamine deficiency	0.000	0.989	0.011
E51.1 Beriberi	0.000	0.989	0.011
M07.3 Other psoriatic arthropathies	0.011	0.989	0.000
M07.39 Other psoriatic arthropathies (Site unspecified)	0.011	0.989	0.000
M80.09 Postmenopausal osteoporosis with pathological fracture (Site unspecified)	0.011	0.989	0.000
M80.08 Postmenopausal osteoporosis with pathological fracture (Other)	0.011	0.989	0.000
M80.07 Postmenopausal osteoporosis with pathological fracture (Ankle and foot)	0.011	0.989	0.000
M80.06 Postmenopausal osteoporosis with pathological fracture (Lower leg)	0.011	0.989	0.000
M80.05 Postmenopausal osteoporosis with pathological fracture (Pelvic region and thigh)	0.011	0.989	0.000
M80.04 Postmenopausal osteoporosis with pathological fracture (Hand)	0.011	0.989	0.000
M80.03 Postmenopausal osteoporosis with pathological fracture (Forearm)	0.011	0.989	0.000
M80.02 Postmenopausal osteoporosis with pathological fracture (Upper arm)	0.011	0.989	0.000
M80.01 Postmenopausal osteoporosis with pathological fracture (Shoulder region)	0.011	0.989	0.000
M84.0 Malunion of fracture	0.011	0.989	0.000
M84.06 Malunion of fracture (Lower leg)	0.011	0.989	0.000
M84 Disorders of continuity of bone	0.010	0.990	0.000
E00-E07 Disorders of thyroid gland	0.001	0.990	0.010
E55.0 Rickets, active	0.000	0.990	0.010
S22.40 Multiple fractures of ribs (closed)	0.000	0.990	0.010
E11.5 With peripheral circulatory complications	0.000	0.990	0.010
E53.9 Vitamin B deficiency, unspecified	0.000	0.990	0.010
E11.2 With renal complications	0.000	0.990	0.010
E61.9 Deficiency of nutrient element, unspecified	0.000	0.990	0.009
E61.8 Deficiency of other specified nutrient elements	0.000	0.990	0.009
E61.7 Deficiency of multiple nutrient elements	0.000	0.990	0.009
E61.6 Vanadium deficiency	0.000	0.990	0.009
E61.5 Molybdenum deficiency	0.000	0.990	0.009
E61.4 Chromium deficiency	0.000	0.990	0.009
E61.3 Manganese deficiency	0.000	0.990	0.009
E61.0 Copper deficiency	0.000	0.990	0.009
E53.1 Pyridoxine deficiency	0.000	0.990	0.009
E53.0 Riboflavin deficiency	0.000	0.990	0.009
Q60 Renal agenesis and other reduction defects of kidney	0.009	0.991	0.000
M84.01 Malunion of fracture (Shoulder region)	0.009	0.991	0.000
M84.2 Delayed union of fracture	0.009	0.991	0.000
M84.03 Malunion of fracture (Forearm)	0.009	0.991	0.000
H36.0 Diabetic retinopathy	0.000	0.991	0.009
M85 Other disorders of bone density and structure	0.009	0.991	0.000
M83 Adult osteomalacia	0.009	0.991	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.009	0.991	0.000
M07.34 Other psoriatic arthropathies (Hand)	0.009	0.991	0.000
G43 Migraine	0.009	0.991	0.000
E51.2 Wernicke's encephalopathy	0.000	0.991	0.008
E03 Other hypothyroidism	0.000	0.991	0.008
M07.31 Other psoriatic arthropathies (Shoulder region)	0.009	0.991	0.000
G45 Transient cerebral ischaemic attacks and related syndromes	0.009	0.991	0.000
M84.08 Malunion of fracture (Other)	0.009	0.991	0.000
M84.26 Delayed union of fracture (Lower leg)	0.009	0.991	0.000
Q23 Congenital malformations of aortic and mitral valves	0.009	0.991	0.000
E03.9 Hypothyroidism, unspecified	0.000	0.991	0.009
M84.04 Malunion of fracture (Hand)	0.008	0.991	0.000
Z75.1 Person awaiting admission to adequate facility elsewhere	0.009	0.991	0.000
Q24 Other congenital malformations of heart	0.008	0.991	0.000
H90.0 Conductive hearing loss, bilateral	0.000	0.992	0.008
G43.8 Other migraine	0.008	0.992	0.000
Q24.9 Congenital malformation of the heart, unspecified	0.008	0.992	0.000
M07.38 Other psoriatic arthropathies (Other)	0.008	0.992	0.000
M07.33 Other psoriatic arthropathies (Forearm)	0.008	0.992	0.000
M07.32 Other psoriatic arthropathies (Upper arm)	0.008	0.992	0.000
H90.5 Sensorineural hearing loss, unspecified	0.000	0.992	0.008
Q25 Congenital malformations of great arteries	0.008	0.992	0.000
M85.2 Hyperostosis of skull	0.008	0.992	0.000
H90 Conductive and sensorineural hearing loss	0.000	0.992	0.008
E61.1 Iron deficiency	0.000	0.992	0.008
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)	0.008	0.992	0.000
M84.09 Malunion of fracture (Site unspecified)	0.008	0.992	0.000
M84.00 Malunion of fracture (Multiple sites)	0.008	0.992	0.000
M82 Osteoporosis in diseases classified elsewhere	0.008	0.992	0.000
Q23.1 Congenital insufficiency of aortic valve	0.008	0.992	0.000
M84.3 Stress fracture, not elsewhere classified	0.008	0.992	0.000
Q22 Congenital malformations of pulmonary and tricuspid valves	0.008	0.992	0.000
M84.9 Disorder of continuity of bone, unspecified	0.008	0.992	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.001	0.992	0.007
E00 Congenital iodine-deficiency syndrome	0.001	0.992	0.007
M85.4 Solitary bone cyst	0.008	0.992	0.000
E04.2 Non-toxic multinodular goitre	0.008	0.992	0.000
M84.8 Other disorders of continuity of bone	0.007	0.992	0.000
R21 Rash and other nonspecific skin eruption	0.000	0.992	0.008
M81 Osteoporosis without pathological fracture	0.008	0.992	0.000
M06.3 Rheumatoid nodule	0.008	0.992	0.000
G56.8 Other mononeuropathies of upper limb	0.008	0.992	0.000
H90.2 Conductive hearing loss, unspecified	0.000	0.992	0.008
M84.05 Malunion of fracture (Pelvic region and thigh)	0.007	0.992	0.000
Q26 Congenital malformations of great veins	0.007	0.992	0.000
G56.2 Lesion of ulnar nerve	0.007	0.993	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.000	0.993	0.007
E61.2 Magnesium deficiency	0.000	0.993	0.007
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.007	0.993	0.000
M07 Psoriatic and enteropathic arthropathies	0.007	0.993	0.000
Q60.2 Renal agenesis, unspecified	0.007	0.993	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.007	0.993	0.000
M06.34 Rheumatoid nodule (Hand)	0.007	0.993	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.993	0.007
M85.22 Hyperostosis of skull-Upper arm	0.007	0.993	0.000
Q24.4 Congenital subaortic stenosis	0.007	0.993	0.000
M84.07 Malunion of fracture (Ankle and foot)	0.007	0.993	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.000	0.993	0.007
M84.02 Malunion of fracture (Upper arm)	0.007	0.993	0.000
M84.21 Delayed union of fracture (Shoulder region)	0.007	0.993	0.000
G56.3 Lesion of radial nerve	0.007	0.993	0.000
K31.1 Adult hypertrophic pyloric stenosis	0.007	0.993	0.000
Q60-Q64 Congenital malformations of the urinary system	0.007	0.993	0.000
Q25.0 Patent ductus arteriosus	0.007	0.993	0.000
Q25.3 Stenosis of aorta	0.007	0.993	0.000
H90.3 Sensorineural hearing loss, bilateral	0.000	0.993	0.007
Q23.0 Congenital stenosis of aortic valve	0.007	0.993	0.000
Q60.6 Potter's syndrome	0.007	0.993	0.000
Q60.5 Renal hypoplasia, unspecified	0.007	0.993	0.000
Q60.4 Renal hypoplasia, bilateral	0.007	0.993	0.000
Q60.3 Renal hypoplasia, unilateral	0.007	0.993	0.000
Q60.1 Renal agenesis, bilateral	0.007	0.993	0.000
M83.8 Other adult osteomalacia	0.007	0.993	0.000
M84.29 Delayed union of fracture (Site unspecified)	0.007	0.993	0.000
M84.28 Delayed union of fracture (Other)	0.007	0.993	0.000
M84.27 Delayed union of fracture (Ankle and foot)	0.007	0.993	0.000
M84.25 Delayed union of fracture (Pelvic region and thigh)	0.007	0.993	0.000
M84.24 Delayed union of fracture (Hand)	0.007	0.993	0.000
M84.23 Delayed union of fracture (Forearm)	0.007	0.993	0.000
M84.22 Delayed union of fracture (Upper arm)	0.007	0.993	0.000
M84.20 Delayed union of fracture (Multiple sites)	0.007	0.993	0.000
G45.0 Vertebro-basilar artery syndrome	0.007	0.993	0.000
M85.0 Fibrous dysplasia (monostotic)	0.007	0.993	0.000
Q22.5 Ebstein's anomaly	0.007	0.993	0.000
Q50-Q56 Congenital malformations of genital organs	0.007	0.993	0.000
Q25.6 Stenosis of pulmonary artery	0.007	0.993	0.000
M85.5 Aneurysmal bone cyst	0.007	0.993	0.000
M85.3 Osteitis condensans	0.007	0.993	0.000
M85.1 Skeletal fluorosis	0.007	0.993	0.000
M06 Other rheumatoid arthritis	0.007	0.993	0.000
M83.9 Adult osteomalacia, unspecified	0.007	0.993	0.000
M83.5 Other drug-induced osteomalacia in adults	0.007	0.993	0.000
M83.4 Aluminum bone disease	0.007	0.993	0.000
M83.3 Adult osteomalacia due to malnutrition	0.007	0.993	0.000
M83.2 Adult osteomalacia due to malabsorption	0.007	0.993	0.000
M83.0 Puerperal osteomalacia	0.007	0.993	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.007	0.993	0.000
Q24.5 Malformation of coronary vessels	0.007	0.993	0.000
M85.20 Hyperostosis of skull-Mult sites	0.007	0.993	0.000
Q20 Congenital malformations of cardiac chambers and connexions	0.007	0.993	0.000
Q24.0 Dextrocardia	0.007	0.993	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.001	0.993	0.006
G43.2 Status migrainosus	0.007	0.993	0.000
M83.1 Senile osteomalacia	0.006	0.993	0.000
M07.36 Other psoriatic arthropathies (Lower leg)	0.006	0.993	0.000
E03.5 Myxoedema coma	0.000	0.993	0.006
E03.4 Atrophy of thyroid (acquired)	0.000	0.993	0.006
E03.3 Postinfectious hypothyroidism	0.000	0.993	0.006
E03.1 Congenital hypothyroidism without goitre	0.000	0.993	0.006
Q23.3 Congenital mitral insufficiency	0.006	0.993	0.000
G56 Mononeuropathies of upper limb	0.007	0.993	0.000
G45.2 Multiple and bilateral precerebral artery syndromes	0.006	0.993	0.000
Q74 Other congenital malformations of limb(s)	0.006	0.993	0.000
Q24.6 Congenital heart block	0.006	0.993	0.000
M85.45 Solitary bone cyst (Pelvic region and thigh)	0.006	0.994	0.000
Q23.9 Congenital malformation of aortic and mitral valves, unspecified	0.006	0.994	0.000
Q23.8 Other congenital malformations of aortic and mitral valves	0.006	0.994	0.000
Q23.4 Hypoplastic left heart syndrome	0.006	0.994	0.000
Q23.2 Congenital mitral stenosis	0.006	0.994	0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)	0.006	0.994	0.000
Q26.4 Anomalous pulmonary venous connexion, unspecified	0.006	0.994	0.000
Q24.3 Pulmonary infundibular stenosis	0.006	0.994	0.000
Q24.2 Cor triatriatum	0.006	0.994	0.000
Q24.1 Levocardia	0.006	0.994	0.000
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.006	0.994	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations