TreeWAS – Variant ID: rs11231824

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.994	0.006
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.994	0.006
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.992	0.008
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.990	0.010
S80-S89 Injuries to the knee and lower leg	0.990	0.010
S82 Fracture of lower leg, including ankle	0.987	0.013
T88 Other complications of surgical and medical care, not elsewhere classified	0.974	0.026
S82.6 Fracture of lateral malleolus	0.955	0.045
S82.60 Fracture of lateral malleolus (closed)	0.932	0.068
T84.0 Mechanical complication of internal joint prosthesis	0.926	0.074
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.906	0.094
# Top node	0.905	0.095
M20-M25 Other joint disorders	0.903	0.097
S20-S29 Injuries to the thorax	0.896	0.104
T88.7 Unspecified adverse effect of drug or medicament	0.882	0.118
S82.2 Fracture of shaft of tibia	0.877	0.123
Chapter XV Pregnancy, childbirth and the puerperium	0.872	0.128
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.866	0.134
S82.5 Fracture of medial malleolus	0.863	0.136
M25 Other joint disorders, not elsewhere classified	0.857	0.143
O80-O84 Delivery	0.854	0.146
T88.4 Failed or difficult intubation	0.852	0.148
S80 Superficial injury of lower leg	0.848	0.152
S82.1 Fracture of upper end of tibia	0.845	0.155
T85 Complications of other internal prosthetic devices, implants and grafts	0.836	0.164
M23 Internal derangement of knee	0.829	0.171
Chapter VIII Diseases of the ear and mastoid process	0.827	0.173
Chapter II Neoplasms	0.827	0.173
S10-S19 Injuries to the neck	0.817	0.183
S82.4 Fracture of fibula alone	0.816	0.184
M25.7 Osteophyte	0.815	0.185
M80-M85 Disorders of bone density and structure	0.811	0.189
O82 Single delivery by Caesarean section	0.809	0.191
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.806	0.194
T88.5 Other complications of anaesthesia	0.805	0.195
S20 Superficial injury of thorax	0.803	0.197
M65-M68 Disorders of synovium and tendon	0.799	0.201
Chapter XXI Factors influencing health status and contact with health services	0.794	0.206
M24 Other specific joint derangements	0.793	0.207
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.789	0.211
M91-M94 Chondropathies	0.788	0.212
O80 Single spontaneous delivery	0.787	0.213
C51-C58 Malignant neoplasms of female genital organs	0.786	0.214
T88.8 Other specified complications of surgical and medical care, not elsewhere classified	0.785	0.215
M20 Acquired deformities of fingers and toes	0.784	0.216
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.783	0.217
R47-R49 Symptoms and signs involving speech and voice	0.782	0.218
T86 Failure and rejection of transplanted organs and tissues	0.779	0.221
T79-T79 Certain early complications of trauma	0.777	0.223
S82.50 Fracture of medial malleolus (closed)	0.775	0.225
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.771	0.229
R49 Voice disturbances	0.768	0.232
O82.0 Delivery by elective Caesarean section	0.766	0.234
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts	0.766	0.234
M21 Other acquired deformities of limbs	0.764	0.236
S82.21 Fracture of shaft of tibia (open)	0.761	0.239
R49.0 Dysphonia	0.757	0.243
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.756	0.244
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.756	0.244
M23.3 Other meniscus derangements	0.755	0.245
M65 Synovitis and tenosynovitis	0.755	0.245
S80.9 Superficial injury of lower leg, unspecified	0.755	0.245
T87 Complications peculiar to reattachment and amputation	0.754	0.246
H65-H75 Diseases of middle ear and mastoid	0.753	0.247
T20-T25 Burns and corrosions of external body surface, specified by site	0.752	0.248
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.749	0.250
M40-M43 Deforming dorsopathies	0.749	0.251
R23 Other skin changes	0.748	0.252
O94-O99 Other obstetric conditions, not elsewhere classified	0.747	0.253
M23.8 Other internal derangements of knee	0.746	0.254
S82.10 Fracture of upper end of tibia (closed)	0.744	0.256
M25.6 Stiffness of joint, not elsewhere classified	0.744	0.256
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.742	0.258
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered	0.741	0.259
S70-S79 Injuries to the hip and thigh	0.738	0.262
T66-T78 Other and unspecified effects of external causes	0.738	0.262
T80 Complications following infusion, transfusion and therapeutic injection	0.737	0.263
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.737	0.263
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.735	0.265
R91 Abnormal findings on diagnostic imaging of lung	0.730	0.270
S32 Fracture of lumbar spine and pelvis	0.730	0.270
R79 Other abnormal findings of blood chemistry	0.727	0.273
M25.76 Osteophyte (Lower leg)	0.723	0.277
R79.8 Other specified abnormal findings of blood chemistry	0.722	0.278
M65.9 Synovitis and tenosynovitis, unspecified	0.722	0.278
C15-C26 Malignant neoplasms of digestive organs	0.722	0.278
M50-M54 Other dorsopathies	0.721	0.279
S50-S59 Injuries to the elbow and forearm	0.719	0.281
M86-M90 Other osteopathies	0.718	0.282
T33-T35 Frostbite	0.712	0.288
T26-T28 Burns and corrosions confined to eye and internal organs	0.712	0.288
T00-T07 Injuries involving multiple body regions	0.712	0.288
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.711	0.289
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.711	0.289
S88 Traumatic amputation of lower leg	0.710	0.290
S87 Crushing injury of lower leg	0.710	0.290
S86 Injury of muscle and tendon at lower leg level	0.710	0.290
S85 Injury of blood vessels at lower leg level	0.710	0.290
S84 Injury of nerves at lower leg level	0.710	0.290
M25.72 Osteophyte (Upper arm)	0.709	0.291
C56 Malignant neoplasm of ovary	0.709	0.291
S81 Open wound of lower leg	0.708	0.292
S82.20 Fracture of shaft of tibia (closed)	0.708	0.292
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts	0.708	0.292
S82.9 Fracture of lower leg, part unspecified	0.707	0.292
S82.7 Multiple fractures of lower leg	0.707	0.292
M94 Other disorders of cartilage	0.706	0.294
S20.8 Superficial injuries of other and unspecified parts of thorax	0.705	0.295
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances	0.701	0.299
M33 Dermatopolymyositis	0.700	0.300
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.699	0.301
T88.9 Complication of surgical and medical care, unspecified	0.698	0.302
T88.3 Malignant hyperthermia due to anaesthesis	0.698	0.302
T88.2 Shock due to anaesthesia	0.698	0.302
T88.1 Other complications following immunisation, not elsewhere classified	0.698	0.302
T88.0 Infection following immunisation	0.698	0.302
O80.9 Single spontaneous delivery, unspecified	0.696	0.304
M24.1 Other articular cartilage disorders	0.695	0.305
M20.2 Hallux rigidus	0.695	0.305
T84.3 Mechanical complication of other bone devices, implants and grafts	0.694	0.306
S82.40 Fracture of fibula alone (closed)	0.694	0.306
D00-D09 In situ neoplasms	0.691	0.309
S39 Other and unspecified injuries of abdomen, lower back and pelvis	0.686	0.313
S82.61 Fracture of lateral malleolus (open)	0.684	0.316
R23.8 Other and unspecified skin changes	0.684	0.316
H66 Suppurative and unspecified otitis media	0.684	0.316
Z30-Z39 Persons encountering health services in circumstances related to reproduction	0.683	0.317
C50-C50 Malignant neoplasm of breast	0.682	0.318
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.682	0.318
S82.3 Fracture of lower end of tibia	0.681	0.318
M20.3 Other deformity of hallux (acquired)	0.681	0.319
H74 Other disorders of middle ear and mastoid	0.680	0.320
S90-S99 Injuries to the ankle and foot	0.678	0.321
Chapter XXII Codes for special purposes	0.676	0.324
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.676	0.324
H60-H62 Diseases of external ear	0.675	0.325
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.675	0.325
S40-S49 Injuries to the shoulder and upper arm	0.675	0.325
S82.0 Fracture of patella	0.671	0.329
M05-M14 Inflammatory polyarthropathies	0.670	0.330
O80.0 Spontaneous vertex delivery	0.668	0.332
S27 Injury of other and unspecified intrathoracic organs	0.667	0.333
M60-M63 Disorders of muscles	0.667	0.333
C51 Malignant neoplasm of vulva	0.667	0.333
M25.0 Haemarthrosis	0.666	0.334
S29 Other and unspecified injuries of thorax	0.666	0.334
M25.78 Osteophyte (Other)	0.666	0.334
M84 Disorders of continuity of bone	0.665	0.335
S82.8 Fractures of other parts of lower leg	0.663	0.337
S22 Fracture of rib(s), sternum and thoracic spine	0.663	0.337
M23.4 Loose body in knee	0.661	0.339
R20 Disturbances of skin sensation	0.660	0.340
M31 Other necrotising vasculopathies	0.660	0.340
S20.3 Other superficial injuries of front wall of thorax	0.659	0.341
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.658	0.342
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)	0.658	0.342
Chapter X Diseases of the respiratory system	0.658	0.342
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.657	0.343
S89 Other and unspecified injuries of lower leg	0.656	0.344
M25.77 Osteophyte (Ankle and foot)	0.656	0.344
R21 Rash and other nonspecific skin eruption	0.654	0.346
M00-M03 Infectious arthropathies	0.654	0.346
T86.1 Kidney transplant failure and rejection	0.654	0.346
M81 Osteoporosis without pathological fracture	0.651	0.349
Chapter XVI Certain conditions originating in the perinatal period	0.649	0.351
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.648	0.352
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.648	0.352
M34 Systemic sclerosis	0.648	0.352
M32 Systemic lupus erythematosus	0.648	0.352
M30 Polyarteritis nodosa and related conditions	0.648	0.352
C57 Malignant neoplasm of other and unspecified female genital organs	0.647	0.353
C80 Malignant neoplasm without specification of site	0.646	0.354
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.645	0.354
S60-S69 Injuries to the wrist and hand	0.645	0.355
S19 Other and unspecified injuries of neck	0.645	0.355
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum	0.645	0.355
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.643	0.357
S28 Crushing injury of thorax and traumatic amputation of part of thorax	0.642	0.358
S26 Injury of heart	0.642	0.358
S25 Injury of blood vessels of thorax	0.642	0.358
S24 Injury of nerves and spinal cord at thorax level	0.642	0.358
S23 Dislocation, sprain and strain of joints and ligaments of thorax	0.642	0.358
S21 Open wound of thorax	0.642	0.358
T11 Other injuries of upper limb, level unspecified	0.642	0.358
T15-T19 Effects of foreign body entering through natural orifice	0.642	0.358
M43 Other deforming dorsopathies	0.641	0.359
C64-C68 Malignant neoplasms of urinary tract	0.641	0.359
H66.9 Otitis media, unspecified	0.641	0.359
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.640	0.360
M65.97 Synovitis and tenosynovitis, unspecified (Ankle and foot)	0.639	0.361
S30 Superficial injury of abdomen, lower back and pelvis	0.639	0.361
Z36 Antenatal screening	0.639	0.361
J30-J39 Other diseases of upper respiratory tract	0.638	0.362
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.638	0.362
T85.2 Mechanical complication of intraocular lens	0.637	0.363
O82.1 Delivery by emergency Caesarean section	0.636	0.364
M10 Gout	0.634	0.366
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)	0.634	0.366
Z35 Supervision of high-risk pregnancy	0.633	0.367
M94.8 Other specified disorders of cartilage	0.632	0.368
M65.91 Synovitis and tenosynovitis, unspecified (Shoulder region)	0.630	0.369
O00-O08 Pregnancy with abortive outcome	0.630	0.370
M80 Osteoporosis with pathological fracture	0.629	0.371
R23.3 Spontaneous ecchymoses	0.627	0.373
R93 Abnormal findings on diagnostic imaging of other body structures	0.625	0.375
O85-O92 Complications predominantly related to the puerperium	0.623	0.377
S80.8 Other superficial injuries of lower leg	0.623	0.377
S14 Injury of nerves and spinal cord at neck level	0.623	0.377
C49 Malignant neoplasm of other connective and soft tissue	0.622	0.378
M25.3 Other instability of joint	0.622	0.378
T79 Certain early complications of trauma, not elsewhere classified	0.621	0.379
O46 Antepartum haemorrhage, not elsewhere classified	0.621	0.379
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis	0.621	0.379
S37 Injury of urinary and pelvic organs	0.621	0.379
S36 Injury of intra-abdominal organs	0.621	0.379
S35 Injury of blood vessels at abdomen, lower back and pelvis level	0.621	0.379
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level	0.621	0.379
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis	0.621	0.379
S31 Open wound of abdomen, lower back and pelvis	0.621	0.379
S82.51 Fracture of medial malleolus (open)	0.619	0.381
M24.0 Loose body in joint	0.618	0.382
J33 Nasal polyp	0.618	0.382
H74.0 Tympanosclerosis	0.617	0.383
M25.4 Effusion of joint	0.617	0.383
Z70-Z76 Persons encountering health services in other circumstances	0.616	0.384
M25.9 Joint disorder, unspecified	0.615	0.385
M25.2 Flail joint	0.615	0.385
M25.1 Fistula of joint	0.615	0.385
M21.3 Wrist or foot drop (acquired)	0.613	0.387
O84 Multiple delivery	0.613	0.387
O83 Other assisted single delivery	0.613	0.387
D04 Carcinoma in situ of skin	0.612	0.388
C25 Malignant neoplasm of pancreas	0.612	0.388
S80.7 Multiple superficial injuries of lower leg	0.608	0.392
C53 Malignant neoplasm of cervix uteri	0.608	0.392
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.608	0.392
S10 Superficial injury of neck	0.608	0.392
S32.7 Multiple fractures of lumbar spine and pelvis	0.608	0.392
M10.9 Gout, unspecified	0.607	0.393
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.607	0.393
S82.11 Fracture of upper end of tibia (open)	0.606	0.394
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.605	0.395
C20 Malignant neoplasm of rectum	0.605	0.395
O81 Single delivery by forceps and vacuum extractor	0.604	0.395
M82 Osteoporosis in diseases classified elsewhere	0.604	0.396
R20.8 Other and unspecified disturbances of skin sensation	0.604	0.396
Z57 Occupational exposure to risk-factors	0.603	0.397
C45 Mesothelioma	0.602	0.398
J33.9 Nasal polyp, unspecified	0.600	0.400
Chapter I Certain infectious and parasitic diseases	0.599	0.401
T85.9 Unspecified complication of internal prosthetic device, implant and graft	0.599	0.401
T85.1 Mechanical complication of implanted electronic stimulator of nervous system	0.599	0.401
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt	0.599	0.401
M21.2 Flexion deformity	0.597	0.403
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.596	0.404
S80.1 Contusion of other and unspecified parts of lower leg	0.595	0.405
O20-O29 Other maternal disorders predominantly related to pregnancy	0.595	0.405
M85 Other disorders of bone density and structure	0.595	0.405
M23.5 Chronic instability of knee	0.594	0.406
M23.9 Internal derangement of knee, unspecified	0.594	0.406
M23.1 Discoid meniscus (congenital)	0.594	0.406
M23.0 Cystic meniscus	0.594	0.406
M20.4 Other hammer toe(s) (acquired)	0.594	0.406
M20.6 Acquired deformity of toe(s), unspecified	0.594	0.406
C40-C41 Malignant neoplasms of bone and articular cartilage	0.593	0.407
M25.71 Osteophyte (Shoulder region)	0.593	0.407
S50 Superficial injury of forearm	0.592	0.408
T87.4 Infection of amputation stump	0.591	0.408
H90-H95 Other disorders of ear	0.590	0.410
S12 Fracture of neck	0.589	0.411
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.588	0.412
S13 Dislocation, sprain and strain of joints and ligaments at neck level	0.587	0.413
T31 Burns classified according to extent of body surface involved	0.586	0.414
C64 Malignant neoplasm of kidney, except renal pelvis	0.586	0.414
M25.8 Other specified joint disorders	0.586	0.414
S17 Crushing injury of neck	0.585	0.414
S15 Injury of blood vessels at neck level	0.585	0.414
S11 Open wound of neck	0.585	0.414
S18 Traumatic amputation at neck level	0.585	0.414
S16 Injury of muscle and tendon at neck level	0.585	0.414
S80.0 Contusion of knee	0.585	0.415
M65.93 Synovitis and tenosynovitis, unspecified (Forearm)	0.585	0.415
S82.41 Fracture of fibula alone (open)	0.585	0.415
C23 Malignant neoplasm of gallbladder	0.585	0.415
Z36.0 Antenatal screening for chromosomal anomalies	0.585	0.415
M94.86 Other specified disorders of cartilage (Lower leg)	0.585	0.415
M25.79 Osteophyte (Site unspecified)	0.584	0.416
M25.73 Osteophyte (Forearm)	0.584	0.416
M25.70 Osteophyte (Multiple sites)	0.584	0.416
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.584	0.416
C48 Malignant neoplasm of retroperitoneum and peritoneum	0.582	0.418
M83 Adult osteomalacia	0.581	0.418
C51.9 Vulva, unspecified	0.581	0.419
O82.9 Delivery by Caesarean section, unspecified	0.580	0.420
O82.8 Other single delivery by Caesarean section	0.580	0.420
O82.2 Delivery by Caesarean hysterectomy	0.580	0.420
S32.4 Fracture of acetabulum	0.580	0.420
M65.8 Other synovitis and tenosynovitis	0.580	0.420
M66 Spontaneous rupture of synovium and tendon	0.578	0.421
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.578	0.422
T23 Burn and corrosion of wrist and hand	0.578	0.422
R95-R99 Ill-defined and unknown causes of mortality	0.578	0.422
C50 Malignant neoplasm of breast	0.578	0.422
O46.9 Antepartum haemorrhage, unspecified	0.578	0.422
S20.7 Multiple superficial injuries of thorax	0.576	0.424
S20.4 Other superficial injuries of back wall of thorax	0.576	0.424
S20.1 Other and unspecified superficial injuries of breast	0.576	0.424
S20.0 Contusion of breast	0.576	0.424
R23.2 Flushing	0.575	0.425
M25.75 Osteophyte (Pelvic region and thigh)	0.574	0.426
H61 Other disorders of external ear	0.574	0.426
M65.4 Radial styloid tenosynovitis [de Quervain]	0.574	0.426
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.573	0.427
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.573	0.427
M54 Dorsalgia	0.573	0.427
T68 Hypothermia	0.573	0.427
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.572	0.428
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.571	0.429
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.571	0.429
M24.17 Other articular cartilage disorders (Ankle and foot)	0.570	0.430
M86 Osteomyelitis	0.569	0.431
M65.94 Synovitis and tenosynovitis, unspecified (Hand)	0.569	0.431
M24.9 Joint derangement, unspecified	0.569	0.431
M24.8 Other specific joint derangements, not elsewhere classified	0.569	0.431
M24.7 Protrusio acetabuli	0.569	0.431
M24.6 Ankylosis of joint	0.569	0.431
M24.5 Contracture of joint	0.569	0.431
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.569	0.431
Z00-Z13 Persons encountering health services for examination and investigation	0.568	0.432
T80.8 Other complications following infusion, transfusion and therapeutic injection	0.567	0.433
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.567	0.433
M23.6 Other spontaneous disruption of ligament(s) of knee	0.566	0.433
M89 Other disorders of bone	0.566	0.434
M24.4 Recurrent dislocation and subluxation of joint	0.566	0.434
M92 Other juvenile osteochondrosis	0.565	0.435
M91 Juvenile osteochondrosis of hip and pelvis	0.565	0.435
M21.0 Valgus deformity, not elsewhere classified	0.565	0.435
T85.4 Mechanical complication of breast prosthesis and implant	0.565	0.435
S72 Fracture of femur	0.565	0.435
S22.3 Fracture of rib	0.564	0.435
M24.2 Disorder of ligament	0.564	0.436
O80.8 Other single spontaneous delivery	0.564	0.436
O80.1 Spontaneous breech delivery	0.564	0.436
M21.1 Varus deformity, not elsewhere classified	0.564	0.436
C58 Malignant neoplasm of placenta	0.564	0.436
C52 Malignant neoplasm of vagina	0.564	0.436
C55 Malignant neoplasm of uterus, part unspecified	0.564	0.436
H72 Perforation of tympanic membrane	0.563	0.437
R49.8 Other and unspecified voice disturbances	0.562	0.438
T13 Other injuries of lower limb, level unspecified	0.561	0.438
T09 Other injuries of spine and trunk, level unspecified	0.561	0.438
T12.X1 Fracture of lower limb, level unspecified (open)	0.561	0.438
T12.X0 Fracture of lower limb, level unspecified (closed)	0.561	0.438
T12 Fracture of lower limb, level unspecified	0.561	0.438
T10.X1 Fracture of upper limb, level unspecified (open)	0.561	0.438
T10.X0 Fracture of upper limb, level unspecified (closed)	0.561	0.438
T10 Fracture of upper limb, level unspecified	0.561	0.438
T08.X1 Fracture of spine, level unspecified (open)	0.561	0.438
T08.X0 Fracture of spine, level unspecified (closed)	0.561	0.438
T08 Fracture of spine, level unspecified	0.561	0.438
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified	0.560	0.439
M43.1 Spondylolisthesis	0.560	0.440
H80-H83 Diseases of inner ear	0.560	0.440
S20.2 Contusion of thorax	0.559	0.440
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.559	0.441
T86.9 Failure and rejection of unspecified transplanted organ and tissue	0.559	0.441
T86.4 Liver transplant failure and rejection	0.559	0.441
T86.3 Heart-lung transplant failure and rejection	0.559	0.441
T86.2 Heart transplant failure and rejection	0.559	0.441
T86.0 Bone-marrow transplant rejection	0.559	0.441
M93 Other osteochondropathies	0.558	0.441
S39.9 Unspecified injury of abdomen, lower back and pelvis	0.558	0.442
M10.99 Gout, unspecified (Site unspecified)	0.558	0.442
S79 Other and unspecified injuries of hip and thigh	0.557	0.443
O47 False labour	0.557	0.443
M51 Other intervertebral disk disorders	0.556	0.444
C80.9 Malignant neoplasm, unspecified	0.556	0.444
M31.3 Wegener's granulomatosis	0.556	0.444
Z29 Need for other prophylactic measures	0.555	0.445
M33.1 Other dermatomyositis	0.554	0.446
Z63 Other problems related to primary support group, including family circumstances	0.552	0.448
C50.4 Upper-outer quadrant of breast	0.551	0.449
R49.2 Hypernasality and hyponasality	0.550	0.450
R49.1 Aphonia	0.550	0.450
S32.0 Fracture of lumbar vertebra	0.549	0.450
O32 Maternal care for known or suspected malpresentation of foetus	0.549	0.451
M21.9 Acquired deformity of limb, unspecified	0.548	0.452
M21.8 Other specified acquired deformities of limbs	0.548	0.452
M21.7 Unequal limb length (acquired)	0.548	0.452
M21.6 Other acquired deformities of ankle and foot	0.548	0.452
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.548	0.452
M21.4 Flat foot [pes planus] (acquired)	0.548	0.452
J80-J84 Other respiratory diseases principally affecting the interstitium	0.548	0.452
M94.9 Disorder of cartilage, unspecified	0.547	0.452
M20.0 Deformity of finger(s)	0.547	0.453
M20.5 Other deformities of toe(s) (acquired)	0.547	0.453
C57.0 Fallopian tube	0.547	0.453
S46 Injury of muscle and tendon at shoulder and upper arm level	0.546	0.454
C26 Malignant neoplasm of other and ill-defined digestive organs	0.546	0.454
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.546	0.454
T14 Injury of unspecified body region	0.546	0.454
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis	0.545	0.455
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.544	0.456
Z73 Problems related to life-management difficulty	0.543	0.456
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.543	0.457
C17 Malignant neoplasm of small intestine	0.543	0.457
Z36.9 Antenatal screening, unspecified	0.542	0.458
T32 Corrosions classified according to extent of body surface involved	0.542	0.458
T30 Burn and corrosion, body region unspecified	0.542	0.458
T29 Burns and corrosions of multiple body regions	0.542	0.458
R92 Abnormal findings on diagnostic imaging of breast	0.542	0.458
Z56 Problems related to employment and unemployment	0.542	0.458
C25.9 Pancreas, unspecified	0.542	0.458
M23.37 Other meniscus derangements-Capsular lig	0.542	0.458
M23.49 Loose body in knee-Unspec lig/men	0.542	0.458
T11.0 Superficial injury of upper limb, level unspecified	0.541	0.458
M65.2 Calcific tendinitis	0.541	0.459
M65.1 Other infective (teno)synovitis	0.541	0.459
M65.0 Abscess of tendon sheath	0.541	0.459
J37 Chronic laryngitis and laryngotracheitis	0.541	0.459
Z58 Problems related to physical environment	0.540	0.459
T87.5 Necrosis of amputation stump	0.540	0.460
T87.3 Neuroma of amputation stump	0.540	0.460
T87.2 Complications of other reattached body part	0.540	0.460
T87.1 Complications of reattached (part of) lower extremity	0.540	0.460
T87.0 Complications of reattached (part of) upper extremity	0.540	0.460
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.540	0.460
H70 Mastoiditis and related conditions	0.540	0.460
H68 Eustachian salpingitis and obstruction	0.540	0.460
H67 Otitis media in diseases classified elsewhere	0.540	0.460
T25 Burn and corrosion of ankle and foot	0.539	0.461
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.539	0.461
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.539	0.461
T21 Burn and corrosion of trunk	0.539	0.461
T20 Burn and corrosion of head and neck	0.539	0.461
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.539	0.461
O35 Maternal care for known or suspected foetal abnormality and damage	0.539	0.461
S62 Fracture at wrist and hand level	0.538	0.462
M42 Spinal osteochondrosis	0.537	0.463
M40 Kyphosis and lordosis	0.537	0.463
M35 Other systemic involvement of connective tissue	0.537	0.463
R23.4 Changes in skin texture	0.536	0.464
Z35.1 Supervision of pregnancy with history of abortive outcome	0.536	0.464
R23.1 Pallor	0.536	0.464
R23.0 Cyanosis	0.536	0.464
M53 Other dorsopathies, not elsewhere classified	0.536	0.464
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.536	0.464
O97 Death from sequelae of direct obstetric causes	0.536	0.464
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery	0.536	0.464
O95 Obstetric death of unspecified cause	0.536	0.464
O94 Sequelae of complication of pregnancy, childbirth and the puerperium	0.536	0.464
Z32 Pregnancy examination and test	0.536	0.464
O99.2 Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium	0.536	0.464
M23.87 Other internal derangements of knee (Capsular ligament)	0.535	0.465
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.535	0.465
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.535	0.465
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.535	0.465
M23.80 Other internal derangements of knee (Multiple sites)	0.535	0.465
D03 Melanoma in situ	0.535	0.465
M54.9 Dorsalgia, unspecified	0.535	0.465
M24.13 Other articular cartilage disorders (Forearm)	0.534	0.466
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.533	0.467
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.533	0.467
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.533	0.467
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.533	0.467
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.533	0.467
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.533	0.467
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.533	0.467
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.533	0.467
R79.9 Abnormal finding of blood chemistry, unspecified	0.532	0.468
Z35.0 Supervision of pregnancy with history of infertility	0.532	0.468
C47 Malignant neoplasm of peripheral nerves and autonomic nervous system	0.532	0.468
C46 Kaposi's sarcoma	0.532	0.468
O99.3 Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium	0.531	0.469
O43 Placental disorders	0.531	0.469
S90 Superficial injury of ankle and foot	0.530	0.470
S78 Traumatic amputation of hip and thigh	0.529	0.471
S77 Crushing injury of hip and thigh	0.529	0.471
S76 Injury of muscle and tendon at hip and thigh level	0.529	0.471
S75 Injury of blood vessels at hip and thigh level	0.529	0.471
S74 Injury of nerves at hip and thigh level	0.529	0.471
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.529	0.471
S71 Open wound of hip and thigh	0.529	0.471
T75 Effects of other external causes	0.529	0.471
T74 Maltreatment syndromes	0.529	0.471
T73 Effects of other deprivation	0.529	0.471
T70 Effects of air pressure and water pressure	0.529	0.471
T69 Other effects of reduced temperature	0.529	0.471
T67 Effects of heat and light	0.529	0.471
T71 Asphyxiation	0.529	0.471
T66 Unspecified effects of radiation	0.529	0.471
M25.06 Haemarthrosis (Lower leg)	0.529	0.471
M84.0 Malunion of fracture	0.529	0.471
T80.9 Unspecified complication following infusion, transfusion and therapeutic injection	0.528	0.471
T80.6 Other serum reactions	0.528	0.471
T80.5 Anaphylactic shock due to serum	0.528	0.471
T80.4 Rh incompatibility reaction	0.528	0.471
T80.3 ABO incompatibility reaction	0.528	0.471
T80.1 Vascular complications following infusion, transfusion and therapeutic injection	0.528	0.471
T80.0 Air embolism following infusion, transfusion and therapeutic injection	0.528	0.471

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations