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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs114478677
log Bayes Factor = 24.4689
Chromosome 4   position 109,941,043  (GRCh37) Explore rs114478677 on Ensembl!
Variant rs114478677 is part of Cluster X0214

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
Chapter XI Diseases of the digestive system
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
I30-I52 Other forms of heart disease
0.999 0.001 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.999 0.001 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.998 0.002 0.000
Chapter XXI Factors influencing health status and contact with health services
0.998 0.002 0.000
K55-K64 Other diseases of intestines
0.997 0.003 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.997 0.003 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.995 0.005 0.000
Chapter XX External causes of morbidity and mortality
0.994 0.006 0.000
Chapter VI Diseases of the nervous system
0.994 0.006 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.990 0.010 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.989 0.011 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.983 0.017 0.000
Chapter II Neoplasms
0.983 0.017 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.983 0.017 0.000
Chapter V Mental and behavioural disorders
0.983 0.017 0.000
I80 Phlebitis and thrombophlebitis
0.981 0.019 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.981 0.019 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.980 0.020 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.980 0.020 0.000
K62 Other diseases of anus and rectum
0.978 0.022 0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems
0.976 0.024 0.000
K70-K77 Diseases of liver
0.975 0.025 0.000
M20-M25 Other joint disorders
0.973 0.027 0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.973 0.027 0.000
Z87 Personal history of other diseases and conditions
0.971 0.029 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.970 0.030 0.000
C50-C50 Malignant neoplasm of breast
0.968 0.032 0.000
G40-G47 Episodic and paroxysmal disorders
0.961 0.039 0.000
I35 Nonrheumatic aortic valve disorders
0.959 0.041 0.000
C50 Malignant neoplasm of breast
0.958 0.042 0.000
I47 Paroxysmal tachycardia
0.953 0.047 0.000
F30-F39 Mood [affective] disorders
0.953 0.047 0.000
K61 Abscess of anal and rectal regions
0.952 0.048 0.000
K90-K93 Other diseases of the digestive system
0.950 0.050 0.000
R19 Other symptoms and signs involving the digestive system and abdomen
0.944 0.056 0.000
Z87.1 Personal history of diseases of the digestive system
0.943 0.057 0.000
R10 Abdominal and pelvic pain
0.942 0.058 0.000
R29.6 Tendency to fall, not elsewhere classified
0.942 0.058 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.941 0.059 0.000
R07 Pain in throat and chest
0.939 0.061 0.000
R13 Dysphagia
0.937 0.063 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.937 0.063 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.929 0.071 0.000
K76 Other diseases of liver
0.928 0.072 0.000
D10-D36 Benign neoplasms
0.927 0.073 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.924 0.076 0.000
C50.9 Breast, unspecified
0.921 0.079 0.000
Y83.6 Removal of other organ (partial) (total)
0.921 0.079 0.000
Z93 Artificial opening status
0.921 0.079 0.000
K61.0 Anal abscess
0.920 0.080 0.000
R07.2 Precordial pain
0.919 0.081 0.000
T81 Complications of procedures, not elsewhere classified
0.919 0.081 0.000
I47.1 Supraventricular tachycardia
0.916 0.084 0.000
M25 Other joint disorders, not elsewhere classified
0.916 0.084 0.000
F32 Depressive episode
0.911 0.089 0.000
Y83.8 Other surgical procedures
0.908 0.092 0.000
R50-R69 General symptoms and signs
0.906 0.094 0.000
G47 Sleep disorders
0.906 0.094 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.904 0.096 0.000
I10-I15 Hypertensive diseases
0.902 0.098 0.000
Z98 Other postsurgical states
0.900 0.100 0.000
K56 Paralytic ileus and intestinal obstruction without hernia
0.900 0.100 0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
0.897 0.103 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.895 0.105 0.000
I49 Other cardiac arrhythmias
0.890 0.110 0.000
K62.8 Other specified diseases of anus and rectum
0.890 0.110 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.890 0.110 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.889 0.111 0.000
K76.8 Other specified diseases of liver
0.886 0.114 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.884 0.116 0.000
T43.2 Other and unspecified antidepressants
0.880 0.120 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.880 0.120 0.000
K92 Other diseases of digestive system
0.880 0.120 0.000
Chapter I Certain infectious and parasitic diseases
0.879 0.121 0.000
C50.4 Upper-outer quadrant of breast
0.878 0.122 0.000
G43 Migraine
0.876 0.124 0.000
M45-M49 Spondylopathies
0.874 0.126 0.000
K62.1 Rectal polyp
0.874 0.126 0.000
G35 Multiple sclerosis
0.873 0.127 0.000
Z90.7 Acquired absence of genital organ(s)
0.867 0.133 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.866 0.134 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.865 0.135 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.862 0.138 0.000
I35.0 Aortic (valve) stenosis
0.860 0.140 0.000
R19.8 Other specified symptoms and signs involving the digestive system and abdomen
0.860 0.140 0.000
M25.7 Osteophyte
0.859 0.141 0.000
M50-M54 Other dorsopathies
0.859 0.141 0.000
K62.6 Ulcer of anus and rectum
0.858 0.142 0.000
R15 Faecal incontinence
0.857 0.143 0.000
Z42 Follow-up care involving plastic surgery
0.854 0.146 0.000
D25 Leiomyoma of uterus
0.852 0.148 0.000
I42 Cardiomyopathy
0.852 0.148 0.000
F32.9 Depressive episode, unspecified
0.851 0.149 0.000
K59 Other functional intestinal disorders
0.850 0.150 0.000
M05-M14 Inflammatory polyarthropathies
0.847 0.153 0.000
R19.4 Change in bowel habit
0.844 0.156 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.843 0.157 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.842 0.158 0.000
K02 Dental caries
0.841 0.159 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.839 0.161 0.000
R00 Abnormalities of heart beat
0.837 0.163 0.000
K10 Other diseases of jaws
0.837 0.163 0.000
I31 Other diseases of pericardium
0.836 0.164 0.000
K62.9 Disease of anus and rectum, unspecified
0.836 0.164 0.000
Z87.0 Personal history of diseases of the respiratory system
0.836 0.164 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.835 0.165 0.000
K56.6 Other and unspecified intestinal obstruction
0.834 0.166 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.833 0.167 0.000
K01 Embedded and impacted teeth
0.833 0.167 0.000
I49.9 Cardiac arrhythmia, unspecified
0.829 0.171 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.829 0.171 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.829 0.171 0.000
R10.1 Pain localised to upper abdomen
0.827 0.173 0.000
G47.3 Sleep apnoea
0.826 0.174 0.000
K75 Other inflammatory liver diseases
0.824 0.176 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.824 0.176 0.000
I44 Atrioventricular and left bundle-branch block
0.824 0.176 0.000
I95 Hypotension
0.821 0.179 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.820 0.180 0.000
R10.4 Other and unspecified abdominal pain
0.819 0.181 0.000
Z53 Persons encountering health services for specifie procedures, not carried out
0.819 0.181 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.817 0.183 0.000
K65-K67 Diseases of peritoneum
0.817 0.183 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.817 0.183 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.816 0.184 0.000
Chapter VII Diseases of the eye and adnexa
0.815 0.185 0.000
R05 Cough
0.815 0.185 0.000
B95-B98 Bacterial, viral and other infectious agents
0.814 0.186 0.000
I35.9 Aortic valve disorder, unspecified
0.814 0.186 0.000
M20 Acquired deformities of fingers and toes
0.814 0.186 0.000
R54 Senility
0.812 0.188 0.000
M80-M85 Disorders of bone density and structure
0.812 0.188 0.000
Z93.1 Gastrostomy status
0.810 0.190 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.810 0.190 0.000
K14 Diseases of tongue
0.809 0.191 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.809 0.191 0.000
M22 Disorders of patella
0.808 0.192 0.000
I12 Hypertensive renal disease
0.805 0.195 0.000
M65-M68 Disorders of synovium and tendon
0.805 0.195 0.000
T39.1 4-Aminophenol derivatives
0.805 0.195 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.803 0.197 0.000
Z85 Personal history of malignant neoplasm
0.802 0.198 0.000
K11 Diseases of salivary glands
0.801 0.199 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.801 0.199 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.800 0.200 0.000
Z98.0 Intestinal bypass and anastomosis status
0.800 0.200 0.000
K07 Dentofacial anomalies [including malocclusion]
0.797 0.202 0.000
K90 Intestinal malabsorption
0.797 0.203 0.000
I50 Heart failure
0.797 0.203 0.000
F99-F99 Unspecified mental disorder
0.794 0.206 0.000
M70-M79 Other soft tissue disorders
0.794 0.206 0.000
S40-S49 Injuries to the shoulder and upper arm
0.794 0.206 0.000
X10-X19 Contact with heat and hot substances
0.794 0.206 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.790 0.210 0.000
S90-S99 Injuries to the ankle and foot
0.790 0.210 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.789 0.211 0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas
0.789 0.211 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.789 0.211 0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.788 0.212 0.000
R03 Abnormal blood-pressure reading, without diagnosis
0.787 0.213 0.000
Z85.3 Personal history of malignant neoplasm of breast
0.787 0.213 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.787 0.213 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.785 0.215 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.783 0.217 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.782 0.218 0.000
R26 Abnormalities of gait and mobility
0.780 0.220 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.780 0.220 0.000
R00.0 Tachycardia, unspecified
0.780 0.220 0.000
D32 Benign neoplasm of meninges
0.780 0.220 0.000
I95.9 Hypotension, unspecified
0.779 0.221 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.778 0.222 0.000
K08 Other disorders of teeth and supporting structures
0.778 0.222 0.000
K29 Gastritis and duodenitis
0.778 0.222 0.000
C50.8 Overlapping lesion of breast
0.776 0.223 0.000
I46 Cardiac arrest
0.776 0.224 0.000
M34 Systemic sclerosis
0.775 0.225 0.000
Z42.1 Follow-up care involving plastic surgery of breast
0.775 0.225 0.000
K92.2 Gastro-intestinal haemorrhage, unspecified
0.774 0.226 0.000
G43.9 Migraine, unspecified
0.774 0.226 0.000
Y95 Nosocomial condition
0.773 0.227 0.000
K76.0 Fatty (change of) liver, not elsewhere classified
0.772 0.228 0.000
R25 Abnormal involuntary movements
0.772 0.228 0.000
M25.77 Osteophyte (Ankle and foot)
0.772 0.228 0.000
Y83.3 Surgical operation with formation of external stoma
0.772 0.228 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.772 0.228 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.771 0.229 0.000
R87 Abnormal findings in specimens from female genital organs
0.770 0.229 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.770 0.230 0.000
F33 Recurrent depressive disorder
0.769 0.231 0.000
Z94 Transplanted organ and tissue status
0.769 0.231 0.000
M54 Dorsalgia
0.767 0.233 0.000
K62.4 Stenosis of anus and rectum
0.766 0.234 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.765 0.235 0.000
K70 Alcoholic liver disease
0.764 0.236 0.000
Z43 Attention to artificial openings
0.762 0.237 0.000
M21 Other acquired deformities of limbs
0.762 0.238 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.762 0.238 0.000
Z90.1 Acquired absence of breast(s)
0.760 0.240 0.000
M13 Other arthritis
0.760 0.240 0.000
D25.2 Subserosal leiomyoma of uterus
0.759 0.241 0.000
R52 Pain, not elsewhere classified
0.759 0.241 0.000
I74 Arterial embolism and thrombosis
0.758 0.242 0.000
K29.7 Gastritis, unspecified
0.756 0.244 0.000
F80-F89 Disorders of psychological development
0.756 0.244 0.000
G81 Hemiplegia
0.755 0.245 0.000
K60 Fissure and fistula of anal and rectal regions
0.755 0.245 0.000
Z83 Family history of other specific disorders
0.754 0.246 0.000
R94 Abnormal results of function studies
0.753 0.247 0.000
I38 Endocarditis, valve unspecified
0.752 0.248 0.000
Z48 Other surgical follow-up care
0.752 0.248 0.000
K55 Vascular disorders of intestine
0.749 0.251 0.000
M86-M90 Other osteopathies
0.749 0.251 0.000
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified
0.748 0.252 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.747 0.252 0.000
Z53.0 Procedure not carried out because of contraindication
0.747 0.253 0.000
Z99.2 Dependence on renal dialysis
0.747 0.253 0.000
F31 Bipolar affective disorder
0.746 0.254 0.000
Z87.3 Personal history of diseases of the musculoskeletal system and connective tissue
0.746 0.254 0.000
R53 Malaise and fatigue
0.745 0.255 0.000
Z90.4 Acquired absence of other parts of digestive tract
0.744 0.256 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.743 0.257 0.000
C50.1 Central portion of breast
0.742 0.258 0.000
F60-F69 Disorders of adult personality and behaviour
0.742 0.258 0.000
R10.2 Pelvic and perineal pain
0.742 0.258 0.000
Z91.5 Personal history of self-harm
0.742 0.258 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.742 0.258 0.000
M31 Other necrotising vasculopathies
0.741 0.259 0.000
Z99.8 Dependence on other enabling machines and devices
0.741 0.259 0.000
K02.9 Dental caries, unspecified
0.741 0.259 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.741 0.259 0.000
R10.0 Acute abdomen
0.741 0.259 0.000
X60-X84 Intentional self-harm
0.740 0.260 0.000
G47.1 Disorders of excessive somnolence [hypersomnias]
0.739 0.261 0.000
I44.0 Atrioventricular block, first degree
0.738 0.262 0.000
C64-C68 Malignant neoplasms of urinary tract
0.738 0.262 0.000
Z98.8 Other specified postsurgical states
0.735 0.265 0.000
K10.8 Other specified diseases of jaws
0.734 0.266 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.734 0.266 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.733 0.267 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.733 0.267 0.000
C15-C26 Malignant neoplasms of digestive organs
0.733 0.267 0.000
K56.5 Intestinal adhesions [bands] with obstruction
0.732 0.268 0.000
I42.9 Cardiomyopathy, unspecified
0.732 0.268 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.730 0.270 0.000
Z97 Presence of other devices
0.730 0.270 0.000
F32.0 Mild depressive episode
0.730 0.270 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.730 0.270 0.000
G43.8 Other migraine
0.730 0.270 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.729 0.270 0.000
K30 Dyspepsia
0.729 0.271 0.000
R56 Convulsions, not elsewhere classified
0.729 0.271 0.000
Chapter XXII Codes for special purposes
0.729 0.271 0.000
K72 Hepatic failure, not elsewhere classified
0.728 0.272 0.000
S60-S69 Injuries to the wrist and hand
0.728 0.272 0.000
K01.1 Impacted teeth
0.727 0.273 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.727 0.273 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.726 0.273 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.726 0.273 0.000
I31.3 Pericardial effusion (noninflammatory)
0.726 0.274 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.726 0.274 0.000
K92.0 Haematemesis
0.726 0.274 0.000
I82 Other venous embolism and thrombosis
0.725 0.274 0.000
R60 Oedema, not elsewhere classified
0.725 0.275 0.000
I35.1 Aortic (valve) insufficiency
0.725 0.275 0.000
H30-H36 Disorders of choroid and retina
0.725 0.275 0.000
R07.0 Pain in throat
0.724 0.276 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.723 0.277 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.723 0.277 0.000
Z87.8 Personal history of other specified conditions
0.721 0.279 0.000
I05-I09 Chronic rheumatic heart diseases
0.721 0.279 0.000
R01 Cardiac murmurs and other cardiac sounds
0.720 0.280 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.718 0.282 0.000
R47-R49 Symptoms and signs involving speech and voice
0.718 0.282 0.000
Z49 Care involving dialysis
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
Z93.3 Colostomy status
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.716 0.283 0.000
I48 Atrial fibrillation and flutter
0.716 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.716 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.716 0.283 0.000
I40 Acute myocarditis
0.716 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.716 0.283 0.000
I37 Pulmonary valve disorders
0.716 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.716 0.283 0.000
I33 Acute and subacute endocarditis
0.716 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.716 0.283 0.000
I30 Acute pericarditis
0.716 0.283 0.000
T79-T79 Certain early complications of trauma
0.716 0.284 0.000
T33-T35 Frostbite
0.716 0.284 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.716 0.284 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.716 0.284 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.716 0.284 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.716 0.284 0.000
T00-T07 Injuries involving multiple body regions
0.716 0.284 0.000
S10-S19 Injuries to the neck
0.716 0.284 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.716 0.284 0.000
M91-M94 Chondropathies
0.716 0.284 0.000
M60-M63 Disorders of muscles
0.716 0.284 0.000
M00-M03 Infectious arthropathies
0.716 0.284 0.000
I10 Essential (primary) hypertension
0.716 0.284 0.000
I12.0 Hypertensive renal disease with renal failure
0.715 0.285 0.000
K64 Haemorrhoids and perianal venous thrombosis
0.715 0.285 0.000
Z93.0 Tracheostomy status
0.714 0.286 0.000
Z52 Donors of organs and tissues
0.714 0.286 0.000
Z89 Acquired absence of limb
0.713 0.287 0.000
Z84 Family history of other conditions
0.713 0.287 0.000
Z81 Family history of mental and behavioural disorders
0.713 0.287 0.000
I86 Varicose veins of other sites
0.713 0.287 0.000
G45 Transient cerebral ischaemic attacks and related syndromes
0.713 0.287 0.000
I89.0 Lymphoedema, not elsewhere classified
0.713 0.287 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.713 0.287 0.000
Y35-Y36 Legal intervention and operations of war
0.713 0.287 0.000
Y10-Y34 Event of undetermined intent
0.713 0.287 0.000
Y00-Y09 Assault
0.713 0.287 0.000
X85-X99 Assault
0.713 0.287 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.713 0.287 0.000
X50-X57 Overexertion, travel and privation
0.713 0.287 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.713 0.287 0.000
X30-X39 Exposure to forces of nature
0.713 0.287 0.000
X20-X29 Contact with venomous animals and plants
0.713 0.287 0.000
X00-X09 Exposure to smoke, fire and flames
0.713 0.287 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.713 0.287 0.000
W75-W84 Other accidental threats to breathing
0.713 0.287 0.000
W65-W74 Accidental drowning and submersion
0.713 0.287 0.000
W50-W64 Exposure to animate mechanical forces
0.713 0.287 0.000
W20-W49 Exposure to inanimate mechanical forces
0.713 0.287 0.000
V98-V99 Other and unspecified transport accidents
0.713 0.287 0.000
V95-V97 Air and space transport accidents
0.713 0.287 0.000
V90-V94 Water transport accidents
0.713 0.287 0.000
V80-V89 Other land transport accidents
0.713 0.287 0.000
V70-V79 Bus occupant injured in transport accident
0.713 0.287 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.713 0.287 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.713 0.287 0.000
V40-V49 Car occupant injured in transport accident
0.713 0.287 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.713 0.287 0.000
V20-V29 Motorcycle rider injured in transport accident
0.713 0.287 0.000
V10-V19 Pedal cyclist injured in transport accident
0.713 0.287 0.000
V01-V09 Pedestrian injured in transport accident
0.713 0.287 0.000
G70-G73 Diseases of myoneural junction and muscle
0.712 0.288 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.712 0.288 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.712 0.288 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.711 0.289 0.000
I47.2 Ventricular tachycardia
0.710 0.290 0.000
G47.9 Sleep disorder, unspecified
0.710 0.290 0.000
I88 Nonspecific lymphadenitis
0.710 0.290 0.000
I87 Other disorders of veins
0.710 0.290 0.000
I81 Portal vein thrombosis
0.710 0.290 0.000
Z90.3 Acquired absence of part of stomach
0.710 0.290 0.000
I83 Varicose veins of lower extremities
0.709 0.291 0.000
R27 Other lack of coordination
0.709 0.291 0.000
Z93.5 Cystostomy status
0.709 0.291 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.708 0.292 0.000
D21.1 Connective and other soft tissue of upper limb, including shoulder
0.708 0.292 0.000
S50-S59 Injuries to the elbow and forearm
0.708 0.292 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.705 0.295 0.000
Z98.2 Presence of cerebrospinal fluid drainage device
0.705 0.295 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.705 0.295 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.705 0.295 0.000
T87 Complications peculiar to reattachment and amputation
0.705 0.295 0.000
T86 Failure and rejection of transplanted organs and tissues
0.705 0.295 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.705 0.295 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.705 0.295 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.705 0.295 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.705 0.295 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.705 0.295 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.705 0.295 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.705 0.295 0.000
F70-F79 Mental retardation
0.705 0.295 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.705 0.295 0.000
M50 Cervical disk disorders
0.704 0.296 0.000
I80.9 Phlebitis and thrombophlebitis of unspecified site
0.704 0.296 0.000
I80.8 Phlebitis and thrombophlebitis of other sites
0.704 0.296 0.000
Z87.2 Personal history of diseases of the skin and subcutaneous tissue
0.704 0.296 0.000
M48 Other spondylopathies
0.704 0.296 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.704 0.296 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.704 0.296 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.704 0.296 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.704 0.296 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.704 0.296 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.704 0.296 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.704 0.296 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.704 0.296 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.704 0.296 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.704 0.296 0.000
T36 Poisoning by systemic antibiotics
0.704 0.296 0.000
R18 Ascites
0.704 0.296 0.000
I49.4 Other and unspecified premature depolarisation
0.703 0.297 0.000
T66-T78 Other and unspecified effects of external causes
0.703 0.297 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.703 0.297 0.000
R50 Fever of unknown origin
0.703 0.297 0.000
K09 Cysts of oral region, not elsewhere classified
0.702 0.298 0.000
K06 Other disorders of gingiva and edentulous alveolar ridge
0.702 0.298 0.000
K03 Other diseases of hard tissues of teeth
0.702 0.298 0.000
K00 Disorders of tooth development and eruption
0.702 0.298 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.702 0.298 0.000
R87.6 Abnormal cytological findings
0.702 0.298 0.000
F43 Reaction to severe stress, and adjustment disorders
0.702 0.298 0.000
M25.78 Osteophyte (Other)
0.702 0.298 0.000
Z46 Fitting and adjustment of other devices
0.702 0.298 0.000
K62.7 Radiation proctitis
0.701 0.299 0.000
K62.2 Anal prolapse
0.701 0.299 0.000
K74 Fibrosis and cirrhosis of liver
0.700 0.300 0.000
Z90.8 Acquired absence of other organs
0.700 0.300 0.000
R29.4 Clicking hip
0.699 0.300 0.000
R29.3 Abnormal posture
0.699 0.300 0.000
R29.2 Abnormal reflex
0.699 0.300 0.000
R29.1 Meningismus
0.699 0.300 0.000
R29.0 Tetany
0.699 0.300 0.000
K77 Liver disorders in diseases classified elsewhere
0.699 0.301 0.000
K73 Chronic hepatitis, not elsewhere classified
0.699 0.301 0.000
K71 Toxic liver disease
0.699 0.301 0.000
F45 Somatoform disorders
0.699 0.301 0.000
M13.9 Arthritis, unspecified
0.698 0.302 0.000
Z93.6 Other artificial openings of urinary tract status
0.698 0.302 0.000
S20-S29 Injuries to the thorax
0.697 0.302 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.697 0.303 0.000
M33 Dermatopolymyositis
0.697 0.303 0.000
M32 Systemic lupus erythematosus
0.697 0.303 0.000
M30 Polyarteritis nodosa and related conditions
0.697 0.303 0.000
F32.3 Severe depressive episode with psychotic symptoms
0.697 0.303 0.000
R09.0 Asphyxia
0.697 0.303 0.000
G30-G32 Other degenerative diseases of the nervous system
0.697 0.303 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.696 0.304 0.000
Z87.6 Personal history of certain conditions arising in the perinatal period
0.696 0.304 0.000
Z87.5 Personal history of complications of pregnancy, childbirth and the puerperium
0.696 0.304 0.000
Y83.9 Surgical procedure, unspecified
0.695 0.305 0.000
Y83.5 Amputation of limb(s)
0.695 0.305 0.000
Y83.0 Surgical operation with transplant of whole organ
0.695 0.305 0.000
Z53.9 Procedure not carried out, unspecified reason
0.695 0.305 0.000
D25.0 Submucous leiomyoma of uterus
0.694 0.306 0.000
M25.76 Osteophyte (Lower leg)
0.694 0.306 0.000
Z91.0 Personal history of allergy, other than to drugs and biological substances
0.694 0.306 0.000
D21.2 Connective and other soft tissue of lower limb, including hip
0.692 0.308 0.000
F32.2 Severe depressive episode without psychotic symptoms
0.692 0.308 0.000
K12 Stomatitis and related lesions
0.692 0.308 0.000
K05 Gingivitis and periodontal diseases
0.691 0.309 0.000
O80-O84 Delivery
0.690 0.310 0.000
I45 Other conduction disorders
0.689 0.311 0.000
M45 Ankylosing spondylitis
0.689 0.311 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.689 0.311 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.689 0.311 0.000
G41 Status epilepticus
0.689 0.311 0.000
M47 Spondylosis
0.688 0.312 0.000
Z36 Antenatal screening
0.688 0.312 0.000
I50.0 Congestive heart failure
0.688 0.312 0.000
I35.8 Other aortic valve disorders
0.688 0.312 0.000
K50-K52 Noninfective enteritis and colitis
0.688 0.312 0.000
K90.0 Coeliac disease
0.687 0.313 0.000
Z41 Procedures for purposes other than remedying health state
0.687 0.313 0.000
C50.6 Axillary tail of breast
0.687 0.313 0.000
C50.3 Lower-inner quadrant of breast
0.687 0.313 0.000
C50.0 Nipple and areola
0.687 0.313 0.000
I77 Other disorders of arteries and arterioles
0.686 0.314 0.000
K81 Cholecystitis
0.686 0.314 0.000
M67 Other disorders of synovium and tendon
0.686 0.314 0.000
M20.2 Hallux rigidus
0.685 0.315 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.685 0.315 0.000
K62.0 Anal polyp
0.684 0.316 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.683 0.317 0.000
I47.0 Reentry ventricular arrhythmia
0.683 0.317 0.000
F38 Other mood [affective] disorders
0.683 0.317 0.000
F34 Persistent mood [affective] disorders
0.683 0.317 0.000
F30 Manic episode
0.683 0.317 0.000
F39 Unspecified mood [affective] disorder
0.683 0.317 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.683 0.317 0.000
K14.8 Other diseases of tongue
0.683 0.317 0.000
K61.4 Intrasphincteric abscess
0.682 0.317 0.000
K61.3 Ischiorectal abscess
0.682 0.317 0.000
K61.2 Anorectal abscess
0.682 0.317 0.000
K61.1 Rectal abscess
0.682 0.317 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.682 0.318 0.000
M35 Other systemic involvement of connective tissue
0.682 0.318 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.681 0.319 0.000
R06 Abnormalities of breathing
0.681 0.319 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.680 0.320 0.000
D60-D64 Aplastic and other anaemias
0.680 0.320 0.000
K75.0 Abscess of liver
0.680 0.320 0.000
Z90.5 Acquired absence of kidney
0.680 0.320 0.000
I70 Atherosclerosis
0.680 0.320 0.000
M40-M43 Deforming dorsopathies
0.680 0.320 0.000
S70-S79 Injuries to the hip and thigh
0.679 0.321 0.000
I85 Oesophageal varices
0.679 0.321 0.000
G81.9 Hemiplegia, unspecified
0.678 0.322 0.000
K92.1 Melaena
0.678 0.322 0.000
R19.6 Halitosis
0.677 0.323 0.000
R19.3 Abdominal rigidity
0.677 0.323 0.000
R19.2 Visible peristalsis
0.677 0.323 0.000
R19.1 Abnormal bowel sounds
0.677 0.323 0.000
G44 Other headache syndromes
0.676 0.323 0.000
R17 Unspecified jaundice
0.676 0.323 0.000
I42.1 Obstructive hypertrophic cardiomyopathy
0.675 0.325 0.000
K59.9 Functional intestinal disorder, unspecified
0.675 0.325 0.000
Z90.0 Acquired absence of part of head and neck
0.675 0.325 0.000
R63 Symptoms and signs concerning food and fluid intake
0.674 0.326 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

This website was created, designed, and edited by ORCID iD iconPatrick K. Albers

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