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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs114517646
log Bayes Factor = 10.2252
Chromosome 1   position 76,033,729  (GRCh37) Explore rs114517646 on Ensembl!
Variant rs114517646 is part of Cluster X0076

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter XX External causes of morbidity and mortality
0.999 0.001 0.000
Chapter II Neoplasms
0.998 0.002 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.998 0.002 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.998 0.002 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.998 0.002 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.996 0.004 0.000
M20-M25 Other joint disorders
0.994 0.006 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.994 0.006 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.994 0.006 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.992 0.008 0.000
D68 Other coagulation defects
0.984 0.016 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.979 0.021 0.000
C50-C50 Malignant neoplasm of breast
0.978 0.022 0.000
Y43 Primarily systemic agents
0.973 0.027 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.973 0.027 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.972 0.028 0.000
Chapter I Certain infectious and parasitic diseases
0.963 0.037 0.000
C50 Malignant neoplasm of breast
0.963 0.037 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.963 0.037 0.000
C77.5 Intrapelvic lymph nodes
0.962 0.038 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.960 0.040 0.000
Y43.3 Other antineoplastic drugs
0.959 0.041 0.000
Chapter XIV Diseases of the genitourinary system
0.957 0.043 0.000
C77.9 Lymph node, unspecified
0.953 0.047 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.947 0.053 0.000
C50.9 Breast, unspecified
0.944 0.056 0.000
D70 Agranulocytosis
0.944 0.056 0.000
Y52 Agents primarily affecting the cardiovascular system
0.943 0.057 0.000
C77.2 Intra-abdominal lymph nodes
0.942 0.058 0.000
A30-A49 Other bacterial diseases
0.938 0.062 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.937 0.063 0.000
M23 Internal derangement of knee
0.935 0.065 0.000
D68.2 Hereditary deficiency of other clotting factors
0.933 0.067 0.000
N10-N16 Renal tubulo-interstitial diseases
0.925 0.075 0.000
O60-O75 Complications of labour and delivery
0.924 0.076 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.924 0.076 0.000
M24 Other specific joint derangements
0.923 0.077 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.920 0.080 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.920 0.080 0.000
M91-M94 Chondropathies
0.914 0.086 0.000
N13 Obstructive and reflux uropathy
0.911 0.089 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.910 0.090 0.000
C77.0 Lymph nodes of head, face and neck
0.908 0.092 0.000
M45-M49 Spondylopathies
0.906 0.094 0.000
D69 Purpura and other haemorrhagic conditions
0.905 0.095 0.000
A41 Other septicaemia
0.904 0.096 0.000
R30-R39 Symptoms and signs involving the urinary system
0.903 0.097 0.000
M40-M43 Deforming dorsopathies
0.898 0.102 0.000
M23.8 Other internal derangements of knee
0.896 0.104 0.000
N13.5 Kinking and stricture of ureter without hydronephrosis
0.890 0.110 0.000
T39.1 4-Aminophenol derivatives
0.888 0.112 0.000
N30-N39 Other diseases of urinary system
0.881 0.119 0.000
R31 Unspecified haematuria
0.880 0.120 0.000
N17-N19 Renal failure
0.880 0.120 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.880 0.120 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.878 0.122 0.000
R21 Rash and other nonspecific skin eruption
0.877 0.123 0.000
N30 Cystitis
0.875 0.125 0.000
T90 Sequelae of injuries of head
0.873 0.127 0.000
Y83.8 Other surgical procedures
0.872 0.128 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.869 0.131 0.000
O72 Postpartum haemorrhage
0.868 0.132 0.000
M22 Disorders of patella
0.861 0.139 0.000
M35 Other systemic involvement of connective tissue
0.860 0.140 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.859 0.141 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.859 0.141 0.000
T92 Sequelae of injuries of upper limb
0.859 0.141 0.000
R39 Other symptoms and signs involving the urinary system
0.858 0.142 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.855 0.145 0.000
M48 Other spondylopathies
0.854 0.146 0.000
N17 Acute renal failure
0.852 0.148 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.847 0.153 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.843 0.157 0.000
B35-B49 Mycoses
0.839 0.161 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.838 0.162 0.000
A41.1 Septicaemia due to other specified staphylococcus
0.833 0.167 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.833 0.167 0.000
N17.9 Acute renal failure, unspecified
0.832 0.168 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.831 0.169 0.000
R47-R49 Symptoms and signs involving speech and voice
0.830 0.170 0.000
D68.5 Primary Thrombophilia
0.830 0.170 0.000
N30.2 Other chronic cystitis
0.829 0.171 0.000
Y52.4 Angiotensin-converting-enzyme inhibitors
0.827 0.173 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.827 0.173 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.826 0.174 0.000
O72.1 Other immediate postpartum haemorrhage
0.825 0.175 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.825 0.175 0.000
N75 Diseases of Bartholin's gland
0.824 0.176 0.000
T66-T78 Other and unspecified effects of external causes
0.824 0.176 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.820 0.180 0.000
W20-W49 Exposure to inanimate mechanical forces
0.820 0.180 0.000
Q80-Q89 Other congenital malformations
0.820 0.180 0.000
M94 Other disorders of cartilage
0.817 0.183 0.000
D68.6 Other Thrombophilia
0.817 0.183 0.000
B15-B19 Viral hepatitis
0.816 0.184 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.815 0.185 0.000
D68.9 Coagulation defect, unspecified
0.814 0.186 0.000
M60-M63 Disorders of muscles
0.814 0.186 0.000
C50.8 Overlapping lesion of breast
0.813 0.187 0.000
M25 Other joint disorders, not elsewhere classified
0.812 0.188 0.000
M23.3 Other meniscus derangements
0.811 0.189 0.000
C50.0 Nipple and areola
0.810 0.190 0.000
N73 Other female pelvic inflammatory diseases
0.809 0.190 0.000
C77.3 Axillary and upper limb lymph nodes
0.809 0.191 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.807 0.193 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.806 0.194 0.000
M48.0 Spinal stenosis
0.805 0.195 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.802 0.198 0.000
M24.2 Disorder of ligament
0.801 0.199 0.000
V40-V49 Car occupant injured in transport accident
0.799 0.201 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.799 0.201 0.000
T93 Sequelae of injuries of lower limb
0.797 0.203 0.000
N30.8 Other cystitis
0.797 0.203 0.000
O80-O84 Delivery
0.797 0.203 0.000
T95 Sequelae of burns, corrosions and frostbite
0.795 0.205 0.000
N13.0 Hydronephrosis with ureteropelvic junction obstruction
0.792 0.208 0.000
A40 Streptococcal septicaemia
0.791 0.209 0.000
L40-L45 Papulosquamous disorders
0.791 0.209 0.000
Chapter VIII Diseases of the ear and mastoid process
0.790 0.210 0.000
M41 Scoliosis
0.789 0.211 0.000
X10-X19 Contact with heat and hot substances
0.789 0.211 0.000
Y84.2 Radiological procedure and radiotherapy
0.786 0.214 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.785 0.215 0.000
C50.1 Central portion of breast
0.784 0.216 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.782 0.218 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.781 0.219 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.781 0.219 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.781 0.219 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.780 0.220 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.779 0.221 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.779 0.221 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.778 0.222 0.000
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.776 0.224 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.776 0.224 0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified
0.776 0.224 0.000
M21 Other acquired deformities of limbs
0.776 0.224 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.775 0.225 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.775 0.225 0.000
T92.8 Sequelae of other specified injuries of upper limb
0.775 0.225 0.000
R22.0 Localised swelling, mass and lump, head
0.775 0.225 0.000
S40-S49 Injuries to the shoulder and upper arm
0.773 0.227 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.772 0.228 0.000
Y84.0 Cardiac catheterisation
0.769 0.231 0.000
T90.2 Sequelae of fracture of skull and facial bones
0.768 0.232 0.000
Y48 Anaesthetics and therapeutic gases
0.767 0.233 0.000
B37 Candidiasis
0.767 0.233 0.000
M00-M03 Infectious arthropathies
0.765 0.235 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.765 0.235 0.000
C77.4 Inguinal and lower limb lymph nodes
0.764 0.236 0.000
A41.9 Septicaemia, unspecified
0.764 0.236 0.000
O62 Abnormalities of forces of labour
0.763 0.237 0.000
R23 Other skin changes
0.762 0.238 0.000
T40.6 Other and unspecified narcotics
0.761 0.239 0.000
N30.1 Interstitial cystitis (chronic)
0.761 0.239 0.000
D73 Diseases of spleen
0.760 0.240 0.000
Q60-Q64 Congenital malformations of the urinary system
0.760 0.240 0.000
L40 Psoriasis
0.757 0.243 0.000
N75.1 Abscess of Bartholin's gland
0.756 0.244 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.756 0.244 0.000
M31 Other necrotising vasculopathies
0.756 0.244 0.000
N71 Inflammatory disease of uterus, except cervix
0.755 0.245 0.000
C79 Secondary malignant neoplasm of other sites
0.752 0.248 0.000
Y83.3 Surgical operation with formation of external stoma
0.751 0.249 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.750 0.249 0.000
L40.9 Psoriasis, unspecified
0.751 0.249 0.000
M23.5 Chronic instability of knee
0.750 0.250 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.750 0.250 0.000
T98 Sequelae of other and unspecified effects of external causes
0.750 0.250 0.000
M33 Dermatopolymyositis
0.749 0.251 0.000
T39.0 Salicylates
0.749 0.251 0.000
N30.9 Cystitis, unspecified
0.749 0.251 0.000
R22.2 Localised swelling, mass and lump, trunk
0.749 0.251 0.000
D69.3 Idiopathic thrombocytopenic purpura
0.748 0.252 0.000
B37.0 Candidal stomatitis
0.748 0.252 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.747 0.253 0.000
Q76 Congenital malformations of spine and bony thorax
0.746 0.254 0.000
M86-M90 Other osteopathies
0.745 0.254 0.000
M22.2 Patellofemoral disorders
0.745 0.255 0.000
Q50-Q56 Congenital malformations of genital organs
0.745 0.255 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.742 0.258 0.000
M48.09 Spinal stenosis (Site unspecified)
0.742 0.258 0.000
W00-W19 Falls
0.741 0.259 0.000
S10-S19 Injuries to the neck
0.741 0.259 0.000
Y45.0 Opioids and related analgesics
0.741 0.259 0.000
D69.9 Haemorrhagic condition, unspecified
0.740 0.260 0.000
A41.8 Other specified septicaemia
0.739 0.260 0.000
M95.0 Acquired deformity of nose
0.739 0.261 0.000
Y52.3 Coronary vasodilators, not elsewhere classified
0.739 0.261 0.000
Y83.5 Amputation of limb(s)
0.739 0.261 0.000
Chapter XXI Factors influencing health status and contact with health services
0.738 0.262 0.000
Y00-Y09 Assault
0.738 0.262 0.000
M40 Kyphosis and lordosis
0.737 0.263 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.736 0.264 0.000
R25 Abnormal involuntary movements
0.735 0.265 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.735 0.265 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.735 0.265 0.000
M30 Polyarteritis nodosa and related conditions
0.734 0.266 0.000
R49 Voice disturbances
0.733 0.267 0.000
H65-H75 Diseases of middle ear and mastoid
0.733 0.267 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.733 0.267 0.000
N73.6 Female pelvic peritoneal adhesions
0.732 0.268 0.000
M92 Other juvenile osteochondrosis
0.732 0.268 0.000
Y84.8 Other medical procedures
0.731 0.269 0.000
B99-B99 Other infectious diseases
0.730 0.270 0.000
Y52.1 Calcium-channel blockers
0.729 0.271 0.000
Y43.4 Immunosuppressive agents
0.729 0.271 0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified
0.728 0.272 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.728 0.272 0.000
T51 Toxic effect of alcohol
0.727 0.273 0.000
R26 Abnormalities of gait and mobility
0.727 0.273 0.000
B50-B64 Protozoal diseases
0.726 0.274 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.726 0.274 0.000
O75.2 Pyrexia during labour, not elsewhere classified
0.726 0.274 0.000
M48.02 Spinal stenosis (Cervical region)
0.724 0.276 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.723 0.277 0.000
T78 Adverse effects, not elsewhere classified
0.722 0.278 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.720 0.280 0.000
R39.1 Other difficulties with micturition
0.719 0.281 0.000
N30.4 Irradiation cystitis
0.719 0.281 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.718 0.282 0.000
M35.0 Sicca syndrome [Sjogren]
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
D69.6 Thrombocytopenia, unspecified
0.717 0.283 0.000
Y35-Y36 Legal intervention and operations of war
0.716 0.283 0.000
Y10-Y34 Event of undetermined intent
0.716 0.283 0.000
X85-X99 Assault
0.716 0.283 0.000
X50-X57 Overexertion, travel and privation
0.716 0.283 0.000
X30-X39 Exposure to forces of nature
0.716 0.283 0.000
X00-X09 Exposure to smoke, fire and flames
0.716 0.283 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.716 0.283 0.000
W75-W84 Other accidental threats to breathing
0.716 0.283 0.000
W65-W74 Accidental drowning and submersion
0.716 0.283 0.000
V98-V99 Other and unspecified transport accidents
0.716 0.283 0.000
V95-V97 Air and space transport accidents
0.716 0.283 0.000
V90-V94 Water transport accidents
0.716 0.283 0.000
V70-V79 Bus occupant injured in transport accident
0.716 0.283 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.716 0.283 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.716 0.283 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.716 0.283 0.000
V01-V09 Pedestrian injured in transport accident
0.716 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.716 0.284 0.000
D66 Hereditary factor VIII deficiency
0.716 0.284 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.715 0.284 0.000
N11 Chronic tubulo-interstitial nephritis
0.715 0.284 0.000
M15-M19 Arthrosis
0.715 0.285 0.000
T90.9 Sequelae of unspecified injury of head
0.714 0.286 0.000
T33-T35 Frostbite
0.714 0.286 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.714 0.286 0.000
T00-T07 Injuries involving multiple body regions
0.714 0.286 0.000
C80 Malignant neoplasm without specification of site
0.713 0.287 0.000
D55-D59 Haemolytic anaemias
0.713 0.287 0.000
X60-X84 Intentional self-harm
0.713 0.287 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.712 0.287 0.000
M32 Systemic lupus erythematosus
0.712 0.287 0.000
Y59 Other and unspecified vaccines and biological substances
0.712 0.288 0.000
Y58 Bacterial vaccines
0.712 0.288 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.712 0.288 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.712 0.288 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.712 0.288 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.712 0.288 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.712 0.288 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.712 0.288 0.000
D67 Hereditary factor IX deficiency
0.712 0.288 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.712 0.288 0.000
W50-W64 Exposure to animate mechanical forces
0.712 0.288 0.000
M23.0 Cystic meniscus
0.712 0.288 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.711 0.289 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.711 0.289 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.711 0.289 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.711 0.289 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.711 0.289 0.000
T36 Poisoning by systemic antibiotics
0.711 0.289 0.000
M41.9 Scoliosis, unspecified
0.711 0.289 0.000
M22.4 Chondromalacia patellae
0.710 0.290 0.000
C51-C58 Malignant neoplasms of female genital organs
0.710 0.290 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.709 0.291 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.709 0.291 0.000
Y84.1 Kidney dialysis
0.709 0.291 0.000
O63 Long labour
0.708 0.292 0.000
B65-B83 Helminthiases
0.708 0.292 0.000
N60-N64 Disorders of breast
0.707 0.293 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.707 0.293 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.707 0.293 0.000
M24.27 Disorder of ligament (Ankle and foot)
0.706 0.294 0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)
0.706 0.294 0.000
A46 Erysipelas
0.706 0.294 0.000
M47 Spondylosis
0.706 0.294 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.705 0.294 0.000
D68.4 Acquired coagulation factor deficiency
0.705 0.295 0.000
D68.1 Hereditary factor XI deficiency
0.705 0.295 0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes
0.705 0.295 0.000
Y83.0 Surgical operation with transplant of whole organ
0.705 0.295 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.704 0.295 0.000
S70-S79 Injuries to the hip and thigh
0.704 0.296 0.000
Q79 Congenital malformations of musculoskeletal system, not elsewhere classified
0.704 0.296 0.000
D69.0 Allergic purpura
0.704 0.296 0.000
L20-L30 Dermatitis and eczema
0.703 0.297 0.000
R22.7 Localised swelling, mass and lump, multiple sites
0.703 0.297 0.000
N13.3 Other and unspecified hydronephrosis
0.701 0.299 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.701 0.299 0.000
N13.8 Other obstructive and reflux uropathy
0.700 0.300 0.000
C79.8 Secondary malignant neoplasm of other specified sites
0.699 0.301 0.000
Y43.9 Primarily systemic agent, unspecified
0.698 0.302 0.000
Y43.8 Other primarily systemic agents, not elsewhere classified
0.698 0.302 0.000
Y43.6 Enzymes, not elsewhere classified
0.698 0.302 0.000
Y43.5 Acidifying and alkalising agents
0.698 0.302 0.000
Y43.2 Antineoplastic natural products
0.698 0.302 0.000
Y43.0 Antiallergic and antiemetic drugs
0.698 0.302 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.698 0.302 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.698 0.302 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.698 0.302 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.698 0.302 0.000
M25.0 Haemarthrosis
0.698 0.302 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.697 0.302 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.697 0.303 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.697 0.303 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.697 0.303 0.000
Q35-Q37 Cleft lip and cleft palate
0.697 0.303 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.697 0.303 0.000
C49 Malignant neoplasm of other connective and soft tissue
0.697 0.303 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.696 0.304 0.000
T42.4 Benzodiazepines
0.696 0.304 0.000
T46.1 Calcium-channel blockers
0.696 0.304 0.000
A41.0 Septicaemia due to Staphylococcus aureus
0.695 0.305 0.000
D72 Other disorders of white blood cells
0.695 0.305 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.694 0.306 0.000
R25.2 Cramp and spasm
0.694 0.306 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.692 0.308 0.000
M25.7 Osteophyte
0.692 0.308 0.000
Y83.9 Surgical procedure, unspecified
0.692 0.308 0.000
T92.9 Sequelae of unspecified injury of upper limb
0.691 0.309 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.691 0.309 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.691 0.309 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.691 0.309 0.000
A75-A79 Rickettsioses
0.691 0.309 0.000
A70-A74 Other diseases caused by chlamydiae
0.691 0.309 0.000
A65-A69 Other spirochaetal diseases
0.691 0.309 0.000
A20-A28 Certain zoonotic bacterial diseases
0.691 0.309 0.000
A15-A19 Tuberculosis
0.691 0.309 0.000
C50.6 Axillary tail of breast
0.690 0.309 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.690 0.309 0.000
D74 Methaemoglobinaemia
0.690 0.309 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.690 0.309 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.690 0.309 0.000
Q65 Congenital deformities of hip
0.690 0.310 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.690 0.310 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.689 0.311 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.688 0.312 0.000
N75.0 Cyst of Bartholin's gland
0.688 0.312 0.000
M34 Systemic sclerosis
0.688 0.312 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.685 0.315 0.000
T40.2 Other opioids
0.685 0.315 0.000
Y44 Agents primarily affecting blood constituents
0.685 0.315 0.000
M94.8 Other specified disorders of cartilage
0.685 0.315 0.000
R81 Glycosuria
0.685 0.315 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.683 0.317 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.682 0.318 0.000
Q87 Other specified congenital malformation syndromes affecting multiple systems
0.682 0.318 0.000
X20-X29 Contact with venomous animals and plants
0.681 0.318 0.000
R26.8 Other and unspecified abnormalities of gait and mobility
0.681 0.319 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.681 0.319 0.000
C77.1 Intrathoracic lymph nodes
0.681 0.319 0.000
M62 Other disorders of muscle
0.681 0.319 0.000
M93 Other osteochondropathies
0.680 0.319 0.000
Q00-Q07 Congenital malformations of the nervous system
0.680 0.320 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.680 0.320 0.000
D68.8 Other specified coagulation defects
0.678 0.322 0.000
C50.3 Lower-inner quadrant of breast
0.677 0.322 0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system
0.676 0.324 0.000
Y52.8 Antivaricose drugs, including sclerosing agents
0.676 0.324 0.000
Y52.7 Peripheral vasodilators
0.676 0.324 0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.676 0.324 0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action
0.676 0.324 0.000
T93.1 Sequelae of fracture of femur
0.676 0.324 0.000
M94.2 Chondromalacia
0.676 0.324 0.000
N00-N08 Glomerular diseases
0.674 0.326 0.000
D68.0 Von Willebrand's disease
0.673 0.327 0.000
M18 Arthrosis of first carpometacarpal joint
0.673 0.327 0.000
N25-N29 Other disorders of kidney and ureter
0.673 0.327 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.672 0.328 0.000
A48 Other bacterial diseases, not elsewhere classified
0.672 0.328 0.000
A44 Bartonellosis
0.672 0.328 0.000
A43 Nocardiosis
0.672 0.328 0.000
A42 Actinomycosis
0.672 0.328 0.000
A39 Meningococcal infection
0.672 0.328 0.000
A37 Whooping cough
0.672 0.328 0.000
A36 Diphtheria
0.672 0.328 0.000
A32 Listeriosis
0.672 0.328 0.000
A31 Infection due to other mycobacteria
0.672 0.328 0.000
A30 Leprosy [Hansen's disease]
0.672 0.328 0.000
A38 Scarlet fever
0.672 0.328 0.000
A35 Other tetanus
0.672 0.328 0.000
A34 Obstetrical tetanus
0.672 0.328 0.000
A33 Tetanus neonatorum
0.672 0.328 0.000
A41.2 Septicaemia due to unspecified staphylococcus
0.672 0.328 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.671 0.329 0.000
M47.8 Other spondylosis
0.671 0.329 0.000
M23.9 Internal derangement of knee, unspecified
0.670 0.330 0.000
M23.1 Discoid meniscus (congenital)
0.670 0.330 0.000
T95.2 Sequelae of burn, corrosion and frostbite of upper limb
0.667 0.333 0.000
N63 Unspecified lump in breast
0.666 0.334 0.000
A40.0 Septicaemia due to streptococcus, group A
0.666 0.334 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.666 0.334 0.000
C95 Leukaemia of unspecified cell type
0.666 0.334 0.000
R22.3 Localised swelling, mass and lump, upper limb
0.665 0.335 0.000
C04 Malignant neoplasm of floor of mouth
0.665 0.335 0.000
M35.3 Polymyalgia rheumatica
0.665 0.335 0.000
Z71.9 Counselling, unspecified
0.663 0.337 0.000
N16 Renal tubulo-interstitial disorders in diseases classified elsewhere
0.663 0.337 0.000
N15 Other renal tubulo-interstitial diseases
0.663 0.337 0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
0.663 0.337 0.000
O74 Complications of anaesthesia during labour and delivery
0.663 0.337 0.000
O71 Other obstetric trauma
0.663 0.337 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.663 0.337 0.000
O60 Preterm delivery
0.663 0.337 0.000
Y43.1 Antineoplastic antimetabolites
0.663 0.337 0.000
N13.6 Pyonephrosis
0.663 0.337 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.662 0.338 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.662 0.338 0.000
T39.4 Antirheumatics, not elsewhere classified
0.662 0.338 0.000
T39.2 Pyrazolone derivatives
0.662 0.338 0.000
M70-M79 Other soft tissue disorders
0.662 0.338 0.000
Y84.4 Aspiration of fluid
0.662 0.338 0.000
M24.9 Joint derangement, unspecified
0.662 0.338 0.000
M24.7 Protrusio acetabuli
0.662 0.338 0.000
M24.6 Ankylosis of joint
0.662 0.338 0.000
M24.5 Contracture of joint
0.662 0.338 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.662 0.338 0.000
A80-A89 Viral infections of the central nervous system
0.661 0.339 0.000
O85-O92 Complications predominantly related to the puerperium
0.661 0.339 0.000
N13.4 Hydroureter
0.661 0.339 0.000
N73.9 Female pelvic inflammatory disease, unspecified
0.660 0.340 0.000
M99 Biomechanical lesions, not elsewhere classified
0.659 0.340 0.000
O72.0 Third-stage haemorrhage
0.659 0.341 0.000
R32 Unspecified urinary incontinence
0.659 0.341 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.658 0.342 0.000
R49.0 Dysphonia
0.657 0.343 0.000
Z71.8 Other specified counselling
0.657 0.343 0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)
0.657 0.343 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.656 0.344 0.000
M35.1 Other overlap syndromes
0.655 0.344 0.000
O34.2 Maternal care due to uterine scar from previous surgery
0.655 0.345 0.000
M91 Juvenile osteochondrosis of hip and pelvis
0.655 0.345 0.000
T51.0 Ethanol
0.654 0.346 0.000
N13.7 Vesicoureteral-reflux-associated uropathy
0.653 0.346 0.000
O82 Single delivery by Caesarean section
0.653 0.347 0.000
Y84.9 Medical procedure, unspecified
0.652 0.347 0.000
Y84.7 Blood-sampling
0.652 0.347 0.000
Y84.5 Insertion of gastric or duodenal sound
0.652 0.347 0.000
Y84.3 Shock therapy
0.652 0.347 0.000
B16 Acute hepatitis B
0.651 0.348 0.000
M65-M68 Disorders of synovium and tendon
0.651 0.349 0.000
O63.0 Prolonged first stage (of labour)
0.651 0.349 0.000
D80-D89 Certain disorders involving the immune mechanism
0.649 0.350 0.000
T91 Sequelae of injuries of neck and trunk
0.649 0.351 0.000
M49 Spondylopathies in diseases classified elsewhere
0.649 0.351 0.000
M96.8 Other postprocedural musculoskeletal disorders
0.649 0.351 0.000
V20-V29 Motorcycle rider injured in transport accident
0.649 0.351 0.000
D69.8 Other specified haemorrhagic conditions
0.649 0.351 0.000
D69.4 Other primary thrombocytopenia
0.649 0.351 0.000
D69.2 Other nonthrombocytopenic purpura
0.649 0.351 0.000
D69.1 Qualitative platelet defects
0.649 0.351 0.000
C14 Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx
0.649 0.351 0.000
A41.4 Septicaemia due to anaerobes
0.648 0.351 0.000
A41.3 Septicaemia due to Haemophilus influenzae
0.648 0.351 0.000
Y45.8 Other analgesics and antipyretics
0.648 0.352 0.000
R36 Urethral discharge
0.647 0.352 0.000
C01 Malignant neoplasm of base of tongue
0.645 0.355 0.000
C92 Myeloid leukaemia
0.644 0.356 0.000
A00-A09 Intestinal infectious diseases
0.644 0.356 0.000
M42 Spinal osteochondrosis
0.644 0.356 0.000
V80-V89 Other land transport accidents
0.644 0.356 0.000
X42 Accidental poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.644 0.356 0.000
M23.87 Other internal derangements of knee (Capsular ligament)
0.642 0.357 0.000
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)
0.642 0.357 0.000
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)
0.642 0.357 0.000
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.642 0.357 0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.642 0.357 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.642 0.358 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.642 0.358 0.000
T38.1 Thyroid hormones and substitutes
0.642 0.358 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.642 0.358 0.000
B18 Chronic viral hepatitis
0.642 0.358 0.000
O75.8 Other specified complications of labour and delivery
0.642 0.358 0.000
D37.5 Rectum
0.641 0.359 0.000
Y57 Other and unspecified drugs and medicaments
0.641 0.359 0.000
Q66 Congenital deformities of feet
0.641 0.359 0.000
W25 Contact with sharp glass
0.640 0.360 0.000
O64.0 Obstructed labour due to incomplete rotation of foetal head
0.640 0.360 0.000
H73 Other disorders of tympanic membrane
0.640 0.360 0.000
M24.1 Other articular cartilage disorders
0.639 0.361 0.000
N13.1 Hydronephrosis with ureteral stricture, not elsewhere classified
0.639 0.361 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.639 0.361 0.000
X12 Contact with other hot fluids
0.638 0.362 0.000
S41 Open wound of shoulder and upper arm
0.637 0.363 0.000
Q63 Other congenital malformations of kidney
0.637 0.363 0.000
Q85 Phakomatoses, not elsewhere classified
0.636 0.363 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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