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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs115557540
log Bayes Factor = 7.70262
Chromosome 1   position 76,135,849  (GRCh37) Explore rs115557540 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.999 0.001 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.997 0.003 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.996 0.004 0.000
Chapter XX External causes of morbidity and mortality
0.994 0.006 0.000
D50-D53 Nutritional anaemias
0.983 0.017 0.000
M25 Other joint disorders, not elsewhere classified
0.965 0.035 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.963 0.037 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.962 0.038 0.000
D50 Iron deficiency anaemia
0.958 0.042 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.957 0.043 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.957 0.043 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.954 0.046 0.000
D50.8 Other iron deficiency anaemias
0.954 0.046 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.950 0.050 0.000
M23 Internal derangement of knee
0.949 0.051 0.000
S40-S49 Injuries to the shoulder and upper arm
0.949 0.051 0.000
M86-M90 Other osteopathies
0.948 0.052 0.000
S80-S89 Injuries to the knee and lower leg
0.945 0.055 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.938 0.062 0.000
M50-M54 Other dorsopathies
0.938 0.062 0.000
M35 Other systemic involvement of connective tissue
0.931 0.069 0.000
M22 Disorders of patella
0.930 0.070 0.000
T51 Toxic effect of alcohol
0.922 0.078 0.000
D70 Agranulocytosis
0.922 0.078 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.919 0.081 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.918 0.082 0.000
D68 Other coagulation defects
0.915 0.085 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.908 0.092 0.000
M05-M14 Inflammatory polyarthropathies
0.906 0.094 0.000
S82 Fracture of lower leg, including ankle
0.904 0.096 0.000
W00-W19 Falls
0.903 0.097 0.000
M24 Other specific joint derangements
0.898 0.102 0.000
M35.3 Polymyalgia rheumatica
0.892 0.108 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.889 0.111 0.000
T51.0 Ethanol
0.889 0.111 0.000
M23.3 Other meniscus derangements
0.887 0.113 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.882 0.118 0.000
T84.2 Mechanical complication of internal fixation device of other bones
0.880 0.120 0.000
M89 Other disorders of bone
0.880 0.120 0.000
M65-M68 Disorders of synovium and tendon
0.876 0.124 0.000
D51 Vitamin B12 deficiency anaemia
0.875 0.125 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.873 0.127 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.869 0.131 0.000
T39.1 4-Aminophenol derivatives
0.861 0.139 0.000
M25.7 Osteophyte
0.860 0.140 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.858 0.142 0.000
Chapter I Certain infectious and parasitic diseases
0.848 0.152 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.848 0.152 0.000
Y83.8 Other surgical procedures
0.846 0.154 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.846 0.154 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.838 0.162 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.835 0.165 0.000
T85.9 Unspecified complication of internal prosthetic device, implant and graft
0.834 0.166 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.833 0.167 0.000
M21 Other acquired deformities of limbs
0.830 0.170 0.000
M06 Other rheumatoid arthritis
0.828 0.172 0.000
M23.8 Other internal derangements of knee
0.828 0.172 0.000
S82.8 Fractures of other parts of lower leg
0.827 0.173 0.000
M45-M49 Spondylopathies
0.827 0.173 0.000
M54 Dorsalgia
0.826 0.174 0.000
T46.1 Calcium-channel blockers
0.826 0.174 0.000
M22.4 Chondromalacia patellae
0.825 0.175 0.000
S41 Open wound of shoulder and upper arm
0.824 0.176 0.000
M60-M63 Disorders of muscles
0.824 0.176 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.823 0.177 0.000
M40-M43 Deforming dorsopathies
0.822 0.178 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.821 0.179 0.000
Chapter X Diseases of the respiratory system
0.820 0.180 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.819 0.181 0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.818 0.182 0.000
Y84.2 Radiological procedure and radiotherapy
0.818 0.182 0.000
W20-W49 Exposure to inanimate mechanical forces
0.817 0.183 0.000
S40 Superficial injury of shoulder and upper arm
0.816 0.184 0.000
M53 Other dorsopathies, not elsewhere classified
0.815 0.185 0.000
M24.2 Disorder of ligament
0.814 0.186 0.000
S49 Other and unspecified injuries of shoulder and upper arm
0.812 0.188 0.000
M91-M94 Chondropathies
0.807 0.193 0.000
J30-J39 Other diseases of upper respiratory tract
0.807 0.193 0.000
M22.2 Patellofemoral disorders
0.807 0.193 0.000
M51 Other intervertebral disk disorders
0.804 0.196 0.000
T92 Sequelae of injuries of upper limb
0.804 0.196 0.000
S89 Other and unspecified injuries of lower leg
0.803 0.197 0.000
M25.3 Other instability of joint
0.803 0.197 0.000
D68.6 Other Thrombophilia
0.802 0.198 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.801 0.199 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.799 0.201 0.000
M89.9 Disorder of bone, unspecified
0.795 0.205 0.000
D55-D59 Haemolytic anaemias
0.795 0.205 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.792 0.208 0.000
S90-S99 Injuries to the ankle and foot
0.786 0.214 0.000
D68.8 Other specified coagulation defects
0.785 0.215 0.000
T84.0 Mechanical complication of internal joint prosthesis
0.782 0.218 0.000
M25.0 Haemarthrosis
0.781 0.219 0.000
M86 Osteomyelitis
0.780 0.220 0.000
S81 Open wound of lower leg
0.779 0.221 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.778 0.222 0.000
S20-S29 Injuries to the thorax
0.777 0.223 0.000
M05 Seropositive rheumatoid arthritis
0.773 0.227 0.000
Y84.0 Cardiac catheterisation
0.773 0.227 0.000
S82.80 Fractures of other parts of lower leg (closed)
0.772 0.228 0.000
T81 Complications of procedures, not elsewhere classified
0.772 0.228 0.000
B35-B49 Mycoses
0.771 0.229 0.000
X10-X19 Contact with heat and hot substances
0.769 0.231 0.000
M25.5 Pain in joint
0.767 0.233 0.000
J32 Chronic sinusitis
0.766 0.234 0.000
M23.80 Other internal derangements of knee (Multiple sites)
0.765 0.235 0.000
S82.6 Fracture of lateral malleolus
0.764 0.236 0.000
D72 Other disorders of white blood cells
0.761 0.239 0.000
T84.1 Mechanical complication of internal fixation device of bones of limb
0.761 0.239 0.000
T85.4 Mechanical complication of breast prosthesis and implant
0.761 0.239 0.000
D80-D89 Certain disorders involving the immune mechanism
0.761 0.239 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.761 0.239 0.000
D69 Purpura and other haemorrhagic conditions
0.760 0.240 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.760 0.240 0.000
V40-V49 Car occupant injured in transport accident
0.758 0.242 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.757 0.242 0.000
M65 Synovitis and tenosynovitis
0.757 0.243 0.000
M25.77 Osteophyte (Ankle and foot)
0.757 0.243 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.756 0.244 0.000
Y00-Y09 Assault
0.756 0.244 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.751 0.249 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.750 0.250 0.000
T85.1 Mechanical complication of implanted electronic stimulator of nervous system
0.750 0.250 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.749 0.251 0.000
Y83.9 Surgical procedure, unspecified
0.748 0.252 0.000
M23.0 Cystic meniscus
0.747 0.253 0.000
B15-B19 Viral hepatitis
0.746 0.253 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.746 0.254 0.000
Q60-Q64 Congenital malformations of the urinary system
0.745 0.254 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.744 0.256 0.000
M30 Polyarteritis nodosa and related conditions
0.743 0.257 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.741 0.259 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.740 0.260 0.000
Q80-Q89 Other congenital malformations
0.739 0.261 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.738 0.262 0.000
W13 Fall from, out of or through building or structure
0.738 0.262 0.000
M90 Osteopathies in diseases classified elsewhere
0.737 0.263 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.737 0.263 0.000
M35.1 Other overlap syndromes
0.737 0.263 0.000
T51.9 Alcohol, unspecified
0.737 0.263 0.000
M23.5 Chronic instability of knee
0.736 0.264 0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified
0.735 0.265 0.000
S41.1 Open wound of upper arm
0.735 0.265 0.000
M41 Scoliosis
0.735 0.265 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.734 0.266 0.000
T93 Sequelae of injuries of lower limb
0.734 0.266 0.000
J95-J99 Other diseases of the respiratory system
0.734 0.266 0.000
M31 Other necrotising vasculopathies
0.732 0.268 0.000
T82.1 Mechanical complication of cardiac electronic device
0.732 0.268 0.000
W17 Other fall from one level to another
0.731 0.269 0.000
W02 Fall involving ice-skates, skis, roller-skates or skateboards
0.730 0.270 0.000
M88 Paget's disease of bone [osteitis deformans]
0.729 0.271 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.728 0.272 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.727 0.273 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.727 0.273 0.000
S42 Fracture of shoulder and upper arm
0.726 0.274 0.000
T95 Sequelae of burns, corrosions and frostbite
0.726 0.274 0.000
V80-V89 Other land transport accidents
0.725 0.274 0.000
M06.9 Rheumatoid arthritis, unspecified
0.725 0.275 0.000
M54.2 Cervicalgia
0.725 0.275 0.000
W18 Other fall on same level
0.723 0.277 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.722 0.278 0.000
M54.4 Lumbago with sciatica
0.722 0.278 0.000
J30 Vasomotor and allergic rhinitis
0.721 0.279 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.720 0.280 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.720 0.280 0.000
S40.9 Superficial injury of shoulder and upper arm, unspecified
0.720 0.280 0.000
Y83.4 Other reconstructive surgery
0.720 0.280 0.000
D68.9 Coagulation defect, unspecified
0.719 0.281 0.000
B37 Candidiasis
0.718 0.282 0.000
S10-S19 Injuries to the neck
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
D68.5 Primary Thrombophilia
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
M33 Dermatopolymyositis
0.717 0.283 0.000
M32 Systemic lupus erythematosus
0.717 0.283 0.000
M07 Psoriatic and enteropathic arthropathies
0.717 0.283 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.715 0.285 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.715 0.285 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.715 0.285 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.715 0.285 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.715 0.285 0.000
T36 Poisoning by systemic antibiotics
0.715 0.285 0.000
M15-M19 Arthrosis
0.715 0.285 0.000
T87 Complications peculiar to reattachment and amputation
0.714 0.286 0.000
S49.9 Unspecified injury of shoulder and upper arm
0.714 0.286 0.000
W50-W64 Exposure to animate mechanical forces
0.713 0.287 0.000
Y35-Y36 Legal intervention and operations of war
0.713 0.287 0.000
Y10-Y34 Event of undetermined intent
0.713 0.287 0.000
X85-X99 Assault
0.713 0.287 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.713 0.287 0.000
X50-X57 Overexertion, travel and privation
0.713 0.287 0.000
X30-X39 Exposure to forces of nature
0.713 0.287 0.000
X00-X09 Exposure to smoke, fire and flames
0.713 0.287 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.713 0.287 0.000
W75-W84 Other accidental threats to breathing
0.713 0.287 0.000
W65-W74 Accidental drowning and submersion
0.713 0.287 0.000
V98-V99 Other and unspecified transport accidents
0.713 0.287 0.000
V95-V97 Air and space transport accidents
0.713 0.287 0.000
V90-V94 Water transport accidents
0.713 0.287 0.000
V70-V79 Bus occupant injured in transport accident
0.713 0.287 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.713 0.287 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.713 0.287 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.713 0.287 0.000
V01-V09 Pedestrian injured in transport accident
0.713 0.287 0.000
M23.4 Loose body in knee
0.711 0.289 0.000
M89.8 Other specified disorders of bone
0.711 0.289 0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts
0.710 0.290 0.000
X60-X84 Intentional self-harm
0.710 0.290 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.709 0.291 0.000
T39.0 Salicylates
0.708 0.292 0.000
T38.1 Thyroid hormones and substitutes
0.706 0.294 0.000
D53 Other nutritional anaemias
0.705 0.295 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.704 0.296 0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft
0.703 0.297 0.000
S82.5 Fracture of medial malleolus
0.703 0.297 0.000
M25.71 Osteophyte (Shoulder region)
0.702 0.298 0.000
W15 Fall from cliff
0.699 0.301 0.000
M06.4 Inflammatory polyarthropathy
0.699 0.301 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.697 0.303 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.697 0.303 0.000
M62 Other disorders of muscle
0.697 0.303 0.000
S86 Injury of muscle and tendon at lower leg level
0.696 0.304 0.000
T85.2 Mechanical complication of intraocular lens
0.696 0.304 0.000
X20-X29 Contact with venomous animals and plants
0.696 0.304 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.695 0.305 0.000
D75 Other diseases of blood and blood-forming organs
0.695 0.305 0.000
S46 Injury of muscle and tendon at shoulder and upper arm level
0.695 0.305 0.000
M24.27 Disorder of ligament (Ankle and foot)
0.694 0.306 0.000
S82.3 Fracture of lower end of tibia
0.693 0.307 0.000
M25.2 Flail joint
0.692 0.308 0.000
M25.1 Fistula of joint
0.692 0.308 0.000
Chapter XXII Codes for special purposes
0.691 0.309 0.000
S27 Injury of other and unspecified intrathoracic organs
0.690 0.310 0.000
S89.8 Other specified injuries of lower leg
0.690 0.310 0.000
T85.0 Mechanical complication of ventricular intracranial (communicating) shunt
0.690 0.310 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.690 0.310 0.000
J32.9 Chronic sinusitis, unspecified
0.689 0.311 0.000
M67 Other disorders of synovium and tendon
0.689 0.311 0.000
Q76 Congenital malformations of spine and bony thorax
0.689 0.311 0.000
M18 Arthrosis of first carpometacarpal joint
0.689 0.311 0.000
B37.0 Candidal stomatitis
0.688 0.312 0.000
D50.1 Sideropenic dysphagia
0.686 0.313 0.000
D67 Hereditary factor IX deficiency
0.686 0.314 0.000
D66 Hereditary factor VIII deficiency
0.686 0.314 0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.686 0.314 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.686 0.314 0.000
D74 Methaemoglobinaemia
0.686 0.314 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.686 0.314 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.686 0.314 0.000
M00-M03 Infectious arthropathies
0.686 0.314 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.686 0.314 0.000
D68.3 Haemorrhagic disorder due to circulating anticoagulants
0.685 0.314 0.000
M51.9 Intervertebral disk disorder, unspecified
0.684 0.315 0.000
T65 Toxic effect of other and unspecified substances
0.684 0.316 0.000
T63 Toxic effect of contact with venomous animals
0.684 0.316 0.000
T62 Toxic effect of other noxious substances eaten as food
0.684 0.316 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.684 0.316 0.000
T60 Toxic effect of pesticides
0.684 0.316 0.000
T59 Toxic effect of other gases, fumes and vapours
0.684 0.316 0.000
T57 Toxic effect of other inorganic substances
0.684 0.316 0.000
T56 Toxic effect of metals
0.684 0.316 0.000
T54 Toxic effect of corrosive substances
0.684 0.316 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.684 0.316 0.000
T52 Toxic effect of organic solvents
0.684 0.316 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.684 0.316 0.000
T58 Toxic effect of carbon monoxide
0.684 0.316 0.000
T55 Toxic effect of soaps and detergents
0.684 0.316 0.000
M48 Other spondylopathies
0.684 0.316 0.000
M25.76 Osteophyte (Lower leg)
0.683 0.317 0.000
M14 Arthropathies in other diseases classified elsewhere
0.683 0.317 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.681 0.319 0.000
W10 Fall on and from stairs and steps
0.681 0.319 0.000
Q35-Q37 Cleft lip and cleft palate
0.681 0.319 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.681 0.319 0.000
M23.9 Internal derangement of knee, unspecified
0.681 0.319 0.000
M23.1 Discoid meniscus (congenital)
0.681 0.319 0.000
A30-A49 Other bacterial diseases
0.680 0.320 0.000
S48 Traumatic amputation of shoulder and upper arm
0.680 0.320 0.000
S45 Injury of blood vessels at shoulder and upper arm level
0.680 0.320 0.000
S44 Injury of nerves at shoulder and upper arm level
0.680 0.320 0.000
S47 Crushing injury of shoulder and upper arm
0.680 0.320 0.000
J34 Other disorders of nose and nasal sinuses
0.680 0.320 0.000
M25.8 Other specified joint disorders
0.680 0.320 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.678 0.322 0.000
Q65 Congenital deformities of hip
0.678 0.322 0.000
S88 Traumatic amputation of lower leg
0.678 0.322 0.000
S87 Crushing injury of lower leg
0.678 0.322 0.000
S85 Injury of blood vessels at lower leg level
0.678 0.322 0.000
S84 Injury of nerves at lower leg level
0.678 0.322 0.000
Y79 Orthopaedic devices associated with adverse incidents
0.677 0.323 0.000
M53.9 Dorsopathy, unspecified
0.674 0.325 0.000
T66-T78 Other and unspecified effects of external causes
0.674 0.326 0.000
M18.9 Arthrosis of first carpometacarpal joint, unspecified
0.673 0.327 0.000
Y73 Gastro-enterology and urology devices associated with adverse incidents
0.673 0.327 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.672 0.327 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.672 0.327 0.000
T46.7 Peripheral vasodilators
0.672 0.327 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.672 0.327 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.672 0.327 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.672 0.327 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.672 0.327 0.000
M89.5 Osteolysis
0.672 0.328 0.000
M41.9 Scoliosis, unspecified
0.672 0.328 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.672 0.328 0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified
0.671 0.329 0.000
M94 Other disorders of cartilage
0.669 0.331 0.000
T83.5 Infection and inflammatory reaction due to prosthetic device, implant and graft in urinary system
0.669 0.331 0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)
0.668 0.332 0.000
J30.3 Other allergic rhinitis
0.668 0.332 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.667 0.332 0.000
M35.8 Other specified systemic involvement of connective tissue
0.667 0.332 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.667 0.332 0.000
M35.5 Multifocal fibrosclerosis
0.667 0.332 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.667 0.332 0.000
M35.2 Behcet's disease
0.667 0.332 0.000
T42.4 Benzodiazepines
0.667 0.333 0.000
J35 Chronic diseases of tonsils and adenoids
0.667 0.333 0.000
M22.1 Recurrent subluxation of patella
0.667 0.333 0.000
M22.9 Disorder of patella, unspecified
0.667 0.333 0.000
M22.3 Other derangements of patella
0.667 0.333 0.000
M22.0 Recurrent dislocation of patella
0.667 0.333 0.000
M35.7 Hypermobility syndrome
0.666 0.333 0.000
T92.2 Sequelae of fracture at wrist and hand level
0.666 0.334 0.000
S82.60 Fracture of lateral malleolus (closed)
0.665 0.335 0.000
M21.0 Valgus deformity, not elsewhere classified
0.664 0.336 0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)
0.664 0.336 0.000
T79-T79 Certain early complications of trauma
0.663 0.336 0.000
M25.4 Effusion of joint
0.663 0.337 0.000
S42.1 Fracture of scapula
0.663 0.337 0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.662 0.338 0.000
M22.8 Other disorders of patella
0.662 0.338 0.000
T51.8 Other alcohols
0.661 0.339 0.000
T51.3 Fusel oil
0.661 0.339 0.000
T51.2 2-Propanol
0.661 0.339 0.000
T51.1 Methanol
0.661 0.339 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.660 0.340 0.000
J34.3 Hypertrophy of nasal turbinates
0.660 0.340 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.659 0.341 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.659 0.341 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.658 0.341 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.658 0.341 0.000
T39.4 Antirheumatics, not elsewhere classified
0.658 0.341 0.000
T39.2 Pyrazolone derivatives
0.658 0.341 0.000
M54.22 Cervicalgia (Cervical region)
0.658 0.342 0.000
D68.4 Acquired coagulation factor deficiency
0.656 0.344 0.000
D68.1 Hereditary factor XI deficiency
0.656 0.344 0.000
D68.0 Von Willebrand's disease
0.656 0.344 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.656 0.344 0.000
Q50-Q56 Congenital malformations of genital organs
0.654 0.345 0.000
M25.55 Pain in joint (Pelvic region and thigh)
0.655 0.345 0.000
S82.2 Fracture of shaft of tibia
0.654 0.346 0.000
M47 Spondylosis
0.654 0.346 0.000
M21.6 Other acquired deformities of ankle and foot
0.653 0.347 0.000
M24.0 Loose body in joint
0.653 0.347 0.000
D68.2 Hereditary deficiency of other clotting factors
0.652 0.348 0.000
D52 Folate deficiency anaemia
0.651 0.348 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.651 0.349 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.651 0.349 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.651 0.349 0.000
S82.4 Fracture of fibula alone
0.651 0.349 0.000
T91 Sequelae of injuries of neck and trunk
0.650 0.349 0.000
S70-S79 Injuries to the hip and thigh
0.650 0.350 0.000
M24.26 Disorder of ligament (Lower leg)
0.650 0.350 0.000
M12 Other specific arthropathies
0.650 0.350 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.650 0.350 0.000
M08 Juvenile arthritis
0.650 0.350 0.000
T98 Sequelae of other and unspecified effects of external causes
0.650 0.350 0.000
W07 Fall involving chair
0.649 0.351 0.000
M89.94 Disorder of bone, unspecified (Hand)
0.649 0.351 0.000
M25.06 Haemarthrosis (Lower leg)
0.649 0.351 0.000
S82.9 Fracture of lower leg, part unspecified
0.648 0.352 0.000
S82.7 Multiple fractures of lower leg
0.648 0.352 0.000
W16 Diving or jumping into water causing injury other than drowning or submersion
0.648 0.352 0.000
W14 Fall from tree
0.648 0.352 0.000
W12 Fall on and from scaffolding
0.648 0.352 0.000
W11 Fall on and from ladder
0.648 0.352 0.000
W09 Fall involving playground equipment
0.648 0.352 0.000
W05 Fall involving wheelchair
0.648 0.352 0.000
W04 Fall while being carried or supported by other persons
0.648 0.352 0.000
W03 Other fall on same level due to collision with, or pushing by, another person
0.648 0.352 0.000
W01 Fall on same level from slipping, tripping and stumbling
0.648 0.352 0.000
W00 Fall on same level involving ice and snow
0.648 0.352 0.000
M34 Systemic sclerosis
0.647 0.353 0.000
B18 Chronic viral hepatitis
0.647 0.353 0.000
D58 Other hereditary haemolytic anaemias
0.646 0.354 0.000
S82.0 Fracture of patella
0.645 0.355 0.000
J98 Other respiratory disorders
0.644 0.356 0.000
M24.9 Joint derangement, unspecified
0.644 0.356 0.000
M24.7 Protrusio acetabuli
0.644 0.356 0.000
M24.6 Ankylosis of joint
0.644 0.356 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.644 0.356 0.000
M25.9 Joint disorder, unspecified
0.644 0.356 0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)
0.643 0.356 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.643 0.357 0.000
M96.0 Pseudarthrosis after fusion or arthrodesis
0.643 0.357 0.000
M21.2 Flexion deformity
0.642 0.357 0.000
W08 Fall involving other furniture
0.642 0.358 0.000
M25.36 Other instability of joint (Lower leg)
0.642 0.358 0.000
M65.3 Trigger finger
0.641 0.359 0.000
M25.37 Other instability of joint (Ankle and foot)
0.639 0.361 0.000
V20-V29 Motorcycle rider injured in transport accident
0.638 0.362 0.000
M11 Other crystal arthropathies
0.638 0.362 0.000
Y84.9 Medical procedure, unspecified
0.638 0.362 0.000
Y84.7 Blood-sampling
0.638 0.362 0.000
Y84.5 Insertion of gastric or duodenal sound
0.638 0.362 0.000
Y84.4 Aspiration of fluid
0.638 0.362 0.000
Y84.3 Shock therapy
0.638 0.362 0.000
W44 Foreign body entering into or through eye or natural orifice
0.637 0.363 0.000
M24.24 Disorder of ligament (Hand)
0.637 0.363 0.000
Q00-Q07 Congenital malformations of the nervous system
0.636 0.363 0.000
M23.37 Other meniscus derangements-Capsular lig
0.636 0.364 0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.636 0.364 0.000
M54.6 Pain in thoracic spine
0.634 0.366 0.000
M24.5 Contracture of joint
0.634 0.366 0.000
Q66 Congenital deformities of feet
0.634 0.366 0.000
M45 Ankylosing spondylitis
0.633 0.367 0.000
B99-B99 Other infectious diseases
0.633 0.367 0.000
T92.8 Sequelae of other specified injuries of upper limb
0.632 0.368 0.000
Y84.1 Kidney dialysis
0.631 0.368 0.000
M89.6 Osteopathy after poliomyelitis
0.631 0.369 0.000
M89.4 Other hypertrophic osteo-arthropathy
0.631 0.369 0.000
M89.3 Hypertrophy of bone
0.631 0.369 0.000
M89.2 Other disorders of bone development and growth
0.631 0.369 0.000
M89.1 Epiphyseal arrest
0.631 0.369 0.000
M89.0 Algoneurodystrophy
0.631 0.369 0.000
M54.9 Dorsalgia, unspecified
0.631 0.369 0.000
B65-B83 Helminthiases
0.631 0.369 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.630 0.370 0.000
M66 Spontaneous rupture of synovium and tendon
0.630 0.370 0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)
0.630 0.370 0.000
M89.98 Disorder of bone, unspecified (Other)
0.630 0.370 0.000
M54.46 Lumbago with sciatica (Lumbar region)
0.629 0.371 0.000
S81.8 Open wound of other parts of lower leg
0.629 0.371 0.000
W21 Striking against or struck by sports equipment
0.628 0.372 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.628 0.372 0.000
S90 Superficial injury of ankle and foot
0.628 0.372 0.000
J32.4 Chronic pansinusitis
0.628 0.372 0.000
W25 Contact with sharp glass
0.628 0.372 0.000
D51.8 Other vitamin B12 deficiency anaemias
0.627 0.372 0.000
D51.3 Other dietary vitamin B12 deficiency anaemia
0.627 0.372 0.000
D51.2 Transcobalamin II deficiency
0.627 0.372 0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.627 0.372 0.000
M86.6 Other chronic osteomyelitis
0.625 0.375 0.000
D80 Immunodeficiency with predominantly antibody defects
0.624 0.376 0.000
A80-A89 Viral infections of the central nervous system
0.624 0.376 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.624 0.376 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.623 0.377 0.000
W06 Fall involving bed
0.622 0.378 0.000
T92.1 Sequelae of fracture of arm
0.622 0.378 0.000
M51.0 Lumbar and other intervertebral disk disorders with myelopathy
0.622 0.378 0.000
M25.59 Pain in joint (Site unspecified)
0.622 0.378 0.000
D72.8 Other specified disorders of white blood cells
0.621 0.378 0.000
M21.4 Flat foot [pes planus] (acquired)
0.621 0.379 0.000
T40.6 Other and unspecified narcotics
0.620 0.380 0.000
W13.9 Unspecified place
0.619 0.381 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.618 0.382 0.000
W22 Striking against or struck by other objects
0.618 0.382 0.000
Q18 Other congenital malformations of face and neck
0.617 0.383 0.000
S42.10 Fracture of scapula (closed)
0.617 0.383 0.000
V10-V19 Pedal cyclist injured in transport accident
0.617 0.383 0.000
S81.0 Open wound of knee
0.617 0.383 0.000
M25.79 Osteophyte (Site unspecified)
0.616 0.384 0.000
M25.73 Osteophyte (Forearm)
0.616 0.384 0.000
M25.72 Osteophyte (Upper arm)
0.616 0.384 0.000
M25.70 Osteophyte (Multiple sites)
0.616 0.384 0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.616 0.384 0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
0.615 0.385 0.000
T83.2 Mechanical complication of graft of urinary organ
0.615 0.385 0.000
D73 Diseases of spleen
0.615 0.385 0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.615 0.385 0.000
M25.74 Osteophyte (Hand)
0.614 0.386 0.000
M21.1 Varus deformity, not elsewhere classified
0.614 0.386 0.000
S82.1 Fracture of upper end of tibia
0.613 0.387 0.000
M25.52 Pain in joint (Upper arm)
0.613 0.387 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.612 0.388 0.000
M65.8 Other synovitis and tenosynovitis
0.611 0.389 0.000
M25.50 Pain in joint (Multiple sites)
0.611 0.389 0.000
X45 Accidental poisoning by and exposure to alcohol
0.609 0.391 0.000
M06.3 Rheumatoid nodule
0.608 0.391 0.000
M86.9 Osteomyelitis, unspecified
0.608 0.392 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.608 0.392 0.000
B50-B64 Protozoal diseases
0.608 0.392 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.608 0.392 0.000
A75-A79 Rickettsioses
0.608 0.392 0.000
A70-A74 Other diseases caused by chlamydiae
0.608 0.392 0.000
A65-A69 Other spirochaetal diseases
0.608 0.392 0.000
A20-A28 Certain zoonotic bacterial diseases
0.608 0.392 0.000
A15-A19 Tuberculosis
0.608 0.392 0.000
D69.9 Haemorrhagic condition, unspecified
0.608 0.392 0.000
J32.0 Chronic maxillary sinusitis
0.608 0.392 0.000
W17.4 Street and highway
0.608 0.392 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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