TreeWAS – Variant ID: rs11663697

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
T36-T50 Poisoning by drugs, medicaments and biological substances	0.200	0.800
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.196	0.804
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.192	0.808
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.191	0.809
T43.0 Tricyclic and tetracyclic antidepressants	0.188	0.812
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.185	0.815
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.183	0.817
T39.0 Salicylates	0.167	0.833
T46 Poisoning by agents primarily affecting the cardiovascular system	0.165	0.835
T39.1 4-Aminophenol derivatives	0.158	0.842
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.158	0.842
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.157	0.843
T43.3 Phenothiazine antipsychotics and neuroleptics	0.157	0.843
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.155	0.845
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.149	0.851
T43.5 Other and unspecified antipsychotics and neuroleptics	0.148	0.852
T42.4 Benzodiazepines	0.145	0.855
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.144	0.856
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.144	0.856
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.144	0.856
T41 Poisoning by anaesthetics and therapeutic gases	0.144	0.856
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.144	0.856
T36 Poisoning by systemic antibiotics	0.144	0.856
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.141	0.859
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.140	0.859
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.140	0.859
T39.4 Antirheumatics, not elsewhere classified	0.140	0.859
T39.2 Pyrazolone derivatives	0.140	0.859
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.138	0.862
T43.9 Psychotropic drug, unspecified	0.138	0.862
T43.8 Other psychotropic drugs, not elsewhere classified	0.138	0.862
T43.6 Psychostimulants with abuse potential	0.138	0.862
T43.4 Butyrophenone and thioxanthene neuroleptics	0.138	0.862
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.138	0.862
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.137	0.863
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.137	0.863
T42.5 Mixed antiepileptics, not elsewhere classified	0.137	0.863
T42.3 Barbiturates	0.137	0.863
T42.2 Succinimides and oxazolidinediones	0.137	0.863
T42.1 Iminostilbenes	0.137	0.863
T42.0 Hydantoin derivatives	0.137	0.863
T40.6 Other and unspecified narcotics	0.132	0.868
T50.9 Other and unspecified drugs, medicaments and biological substances	0.126	0.874
T45.0 Antiallergic and antiemetic drugs	0.123	0.877
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.118	0.882
T46.8 Antivaricose drugs, including sclerosing agents	0.118	0.882
T46.7 Peripheral vasodilators	0.118	0.882
T46.5 Other antihypertensive drugs, not elsewhere classified	0.118	0.882
T46.3 Coronary vasodilators, not elsewhere classified	0.118	0.882
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.118	0.882
T46.1 Calcium-channel blockers	0.118	0.882
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.118	0.882
T46.4 Angiotensin-converting-enzyme inhibitors	0.115	0.885
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.113	0.887
T40.8 Lysergide [LSD]	0.113	0.887
T40.7 Cannabis (derivatives)	0.113	0.887
T40.5 Cocaine	0.113	0.887
T40.3 Methadone	0.113	0.887
T40.1 Heroin	0.113	0.887
T40.0 Opium	0.113	0.887
T50.8 Diagnostic agents	0.113	0.887
T50.7 Analeptics and opioid receptor antagonists	0.113	0.887
T50.6 Antidotes and chelating agents, not elsewhere classified	0.113	0.887
T50.5 Appetite depressants	0.113	0.887
T50.4 Drugs affecting uric acid metabolism	0.113	0.887
T50.3 Electrolytic, caloric and water-balance agents	0.113	0.887
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.113	0.887
T50.1 Loop [high-ceiling] diuretics	0.113	0.887
T50.0 Mineralocorticoids and their antagonists	0.113	0.887
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.112	0.887
T45.9 Primarily systemic and haematological agent, unspecified	0.111	0.888
T45.8 Other primarily systemic and haematological agents	0.111	0.888
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.111	0.888
T45.6 Fibrinolysis-affecting drugs	0.111	0.888
T45.5 Anticoagulants	0.111	0.888
T45.4 Iron and its compounds	0.111	0.888
T45.3 Enzymes, not elsewhere classified	0.111	0.888
T45.2 Vitamins, not elsewhere classified	0.111	0.888
T45.1 Antineoplastic and immunosuppressive drugs	0.111	0.888
T40.2 Other opioids	0.111	0.889
T40.4 Other synthetic narcotics	0.108	0.892
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.107	0.893
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.107	0.893
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.107	0.893
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.107	0.893
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.107	0.893
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.107	0.893
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.107	0.893
T44.1 Other parasympathomimetics [cholinergics]	0.107	0.893
T44.0 Anticholinesterase agents	0.107	0.893
T36.9 Systemic antibiotic, unspecified	0.103	0.897
T36.8 Other systemic antibiotics	0.103	0.897
T36.7 Antifungal antibiotics, systemically used	0.103	0.897
T36.6 Rifamycins	0.103	0.897
T36.5 Aminoglycosides	0.103	0.897
T36.4 Tetracyclines	0.103	0.897
T36.3 Macrolides	0.103	0.897
T36.2 Chloramphenicol group	0.103	0.897
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.103	0.897
T36.0 Penicillins	0.103	0.897
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.103	0.897
T37.8 Other specified systemic anti-infectives and antiparasitics	0.103	0.897
T37.5 Antiviral drugs	0.103	0.897
T37.4 Anthelminthics	0.103	0.897
T37.3 Other antiprotozoal drugs	0.103	0.897
T37.2 Antimalarials and drugs acting on other blood protozoa	0.103	0.897
T37.1 Antimycobacterial drugs	0.103	0.897
T37.0 Sulphonamides	0.103	0.897
T41.5 Therapeutic gases	0.103	0.897
T41.4 Anaesthetic, unspecified	0.103	0.897
T41.3 Local anaesthetics	0.103	0.897
T41.2 Other and unspecified general anaesthetics	0.103	0.897
T41.1 Intravenous anaesthetics	0.103	0.897
T41.0 Inhaled anaesthetics	0.103	0.897
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.103	0.897
T47.8 Other agents primarily affecting the gastro-intestinal system	0.103	0.897
T47.7 Emetics	0.103	0.897
T47.6 Antidiarrhoeal drugs	0.103	0.897
T47.5 Digestants	0.103	0.897
T47.4 Other laxatives	0.103	0.897
T47.3 Saline and osmotic laxatives	0.103	0.897
T47.2 Stimulant laxatives	0.103	0.897
T47.1 Other antacids and anti-gastric-secretion drugs	0.103	0.897
T47.0 Histamine H(2)-receptor antagonists	0.103	0.897
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.103	0.897
T48.6 Antiasthmatics, not elsewhere classified	0.103	0.897
T48.5 Anti-common-cold drugs	0.103	0.897
T48.4 Expectorants	0.103	0.897
T48.3 Antitussives	0.103	0.897
T48.2 Other and unspecified agents primarily acting on muscles	0.103	0.897
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.103	0.897
T48.0 Oxytocic drugs	0.103	0.897
T49.9 Topical agent, unspecified	0.103	0.897
T49.8 Other topical agents	0.103	0.897
T49.7 Dental drugs, topically applied	0.103	0.897
T49.6 Otorhinolaryngological drugs and preparations	0.103	0.897
T49.5 Ophthalmological drugs and preparations	0.103	0.897
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.103	0.897
T49.3 Emollients, demulcents and protectants	0.103	0.897
T49.2 Local astringents and local detergents	0.103	0.897
T49.1 Antipruritics	0.103	0.897
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.103	0.897
T38.9 Other and unspecified hormone antagonists	0.099	0.901
T38.8 Other and unspecified hormones and their synthetic substitutes	0.099	0.901
T38.7 Androgens and anabolic congeners	0.099	0.901
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.099	0.901
T38.5 Other oestrogens and progestogens	0.099	0.901
T38.4 Oral contraceptives	0.099	0.901
T38.2 Antithyroid drugs	0.099	0.901
T38.1 Thyroid hormones and substitutes	0.099	0.901
T38.0 Glucocorticoids and synthetic analogues	0.099	0.901
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.094	0.906
T43.2 Other and unspecified antidepressants	0.086	0.914
D75.1 Secondary polycythaemia	0.072	0.928
D69.6 Thrombocytopenia, unspecified	0.072	0.928
D69 Purpura and other haemorrhagic conditions	0.072	0.928
D75 Other diseases of blood and blood-forming organs	0.070	0.930
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.069	0.931
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.069	0.931
D70-D77 Other diseases of blood and blood-forming organs	0.069	0.931
J44.9 Chronic obstructive pulmonary disease, unspecified	0.069	0.931
J44 Other chronic obstructive pulmonary disease	0.068	0.932
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified	0.064	0.936
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.063	0.937
D80-D89 Certain disorders involving the immune mechanism	0.062	0.938
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection	0.062	0.938
D69.3 Idiopathic thrombocytopenic purpura	0.061	0.939
A09.9 Gastroenteritis and colitis of unspecified origin	0.061	0.939
D86 Sarcoidosis	0.058	0.942
J40-J47 Chronic lower respiratory diseases	0.057	0.943
S70-S79 Injuries to the hip and thigh	0.056	0.944
D69.5 Secondary thrombocytopenia	0.056	0.944
J47 Bronchiectasis	0.055	0.945
D72 Other disorders of white blood cells	0.054	0.946
D75.2 Essential thrombocytosis	0.054	0.946
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.053	0.947
D86.9 Sarcoidosis, unspecified	0.053	0.947
A09 Diarrhoea and gastro-enteritis of presumed infectious origin	0.053	0.947
D55-D59 Haemolytic anaemias	0.052	0.948
D69.9 Haemorrhagic condition, unspecified	0.052	0.948
D69.8 Other specified haemorrhagic conditions	0.052	0.948
D69.4 Other primary thrombocytopenia	0.052	0.948
D69.2 Other nonthrombocytopenic purpura	0.052	0.948
D69.1 Qualitative platelet defects	0.052	0.948
D69.0 Allergic purpura	0.052	0.948
S72 Fracture of femur	0.052	0.948
D50-D53 Nutritional anaemias	0.051	0.949
D75.9 Disease of blood and blood-forming organs, unspecified	0.051	0.949
D75.0 Familial erythrocytosis	0.050	0.949
D67 Hereditary factor IX deficiency	0.050	0.950
D66 Hereditary factor VIII deficiency	0.050	0.950
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.050	0.950
D86.0 Sarcoidosis of lung	0.050	0.950
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.050	0.950
D74 Methaemoglobinaemia	0.050	0.950
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.050	0.950
D71 Functional disorders of polymorphonuclear neutrophils	0.050	0.950
S10-S19 Injuries to the neck	0.050	0.950
T66-T78 Other and unspecified effects of external causes	0.049	0.951
B37.0 Candidal stomatitis	0.049	0.951
D73 Diseases of spleen	0.048	0.952
T15-T19 Effects of foreign body entering through natural orifice	0.048	0.952
S90-S99 Injuries to the ankle and foot	0.048	0.952
D75.8 Other specified diseases of blood and blood-forming organs	0.048	0.952
T79-T79 Certain early complications of trauma	0.048	0.952
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.048	0.952
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.047	0.953
D80 Immunodeficiency with predominantly antibody defects	0.047	0.953
S72.3 Fracture of shaft of femur	0.047	0.953
D68 Other coagulation defects	0.046	0.954
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.046	0.954
S72.0 Fracture of neck of femur	0.046	0.954
D70 Agranulocytosis	0.045	0.955
T33-T35 Frostbite	0.045	0.955
T26-T28 Burns and corrosions confined to eye and internal organs	0.045	0.955
T20-T25 Burns and corrosions of external body surface, specified by site	0.045	0.955
T00-T07 Injuries involving multiple body regions	0.045	0.955
T90 Sequelae of injuries of head	0.045	0.955
D84 Other immunodeficiencies	0.045	0.955
D83 Common variable immunodeficiency	0.045	0.955
D82 Immunodeficiency associated with other major defects	0.045	0.955
D81 Combined immunodeficiencies	0.045	0.955
S70 Superficial injury of hip and thigh	0.045	0.955
J43 Emphysema	0.044	0.956
A00-A09 Intestinal infectious diseases	0.044	0.956
S72.30 Fracture of shaft of femur (closed)	0.043	0.957
B37 Candidiasis	0.043	0.957
T94 Sequelae of injuries involving multiple and unspecified body regions	0.043	0.957
D72.1 Eosinophilia	0.043	0.957
S20-S29 Injuries to the thorax	0.043	0.957
B35-B49 Mycoses	0.043	0.957
D51 Vitamin B12 deficiency anaemia	0.042	0.957
A09.0 Other and unspecified gastroenteritis and colitis of infectious origin	0.042	0.958
S72.00 Fracture of neck of femur (closed)	0.042	0.958
J40 Bronchitis, not specified as acute or chronic	0.042	0.958
D86.8 Sarcoidosis of other and combined sites	0.042	0.958
D86.3 Sarcoidosis of skin	0.042	0.958
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.042	0.958
D86.1 Sarcoidosis of lymph nodes	0.042	0.958
J41 Simple and mucopurulent chronic bronchitis	0.041	0.959
S80-S89 Injuries to the knee and lower leg	0.041	0.959
Chapter I Certain infectious and parasitic diseases	0.041	0.959
S00-S09 Injuries to the head	0.041	0.959
D52 Folate deficiency anaemia	0.041	0.959
S78 Traumatic amputation of hip and thigh	0.040	0.960
S77 Crushing injury of hip and thigh	0.040	0.960
S76 Injury of muscle and tendon at hip and thigh level	0.040	0.960
S75 Injury of blood vessels at hip and thigh level	0.040	0.960
S74 Injury of nerves at hip and thigh level	0.040	0.960
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.040	0.960
S71 Open wound of hip and thigh	0.040	0.960
J42 Unspecified chronic bronchitis	0.040	0.960
D73.5 Infarction of spleen	0.040	0.960
T78 Adverse effects, not elsewhere classified	0.040	0.960
D59 Acquired haemolytic anaemia	0.040	0.960
D60-D64 Aplastic and other anaemias	0.040	0.960
D72.8 Other specified disorders of white blood cells	0.040	0.960
S40-S49 Injuries to the shoulder and upper arm	0.040	0.960
S13 Dislocation, sprain and strain of joints and ligaments at neck level	0.039	0.960
T17 Foreign body in respiratory tract	0.039	0.960
D72.9 Disorder of white blood cells, unspecified	0.039	0.961
D72.0 Genetic anomalies of leukocytes	0.039	0.961
J46 Status asthmaticus	0.039	0.961
T90.9 Sequelae of unspecified injury of head	0.039	0.961
T63 Toxic effect of contact with venomous animals	0.039	0.961
T98 Sequelae of other and unspecified effects of external causes	0.038	0.962
T95 Sequelae of burns, corrosions and frostbite	0.038	0.962
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.038	0.962
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.038	0.962
T91 Sequelae of injuries of neck and trunk	0.038	0.962
S72.2 Subtrochanteric fracture	0.038	0.962
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.038	0.962
D58 Other hereditary haemolytic anaemias	0.037	0.962
D57 Sickle-cell disorders	0.037	0.962
D56 Thalassaemia	0.037	0.962
D55 Anaemia due to enzyme disorders	0.037	0.962
S10 Superficial injury of neck	0.038	0.962
T92 Sequelae of injuries of upper limb	0.037	0.963
S72.9 Fracture of femur, part unspecified	0.037	0.963
S72.8 Fractures of other parts of femur	0.037	0.963
S72.7 Multiple fractures of femur	0.037	0.963
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.037	0.963
T79 Certain early complications of trauma, not elsewhere classified	0.037	0.963
D53 Other nutritional anaemias	0.037	0.963
S70.0 Contusion of hip	0.037	0.963
S12 Fracture of neck	0.037	0.963
S72.4 Fracture of lower end of femur	0.036	0.963
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.036	0.963
D80.1 Nonfamilial hypogammaglobulinaemia	0.036	0.964
T14 Injury of unspecified body region	0.036	0.964
S86 Injury of muscle and tendon at lower leg level	0.036	0.964
S90 Superficial injury of ankle and foot	0.036	0.964
D74.9 Methaemoglobinaemia, unspecified	0.036	0.964
D74.8 Other methaemoglobinaemias	0.036	0.964
D74.0 Congenital methaemoglobinaemia	0.036	0.964
D76.3 Other histiocytosis syndromes	0.036	0.964
D76.2 Haemophagocytic syndrome, infection-associated	0.036	0.964
D76.1 Haemophagocytic lymphohistiocytosis	0.036	0.964
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.036	0.964
T94.1 Sequelae of injuries, not specified by body region	0.036	0.964
S17 Crushing injury of neck	0.036	0.964
S15 Injury of blood vessels at neck level	0.036	0.964
S14 Injury of nerves and spinal cord at neck level	0.036	0.964
S11 Open wound of neck	0.036	0.964
S18 Traumatic amputation at neck level	0.036	0.964
S16 Injury of muscle and tendon at neck level	0.036	0.964
D68.9 Coagulation defect, unspecified	0.035	0.964
J43.9 Emphysema, unspecified	0.035	0.965
D63 Anaemia in chronic diseases classified elsewhere	0.035	0.965
T75 Effects of other external causes	0.035	0.965
T74 Maltreatment syndromes	0.035	0.965
T73 Effects of other deprivation	0.035	0.965
T70 Effects of air pressure and water pressure	0.035	0.965
T69 Other effects of reduced temperature	0.035	0.965
T67 Effects of heat and light	0.035	0.965
T71 Asphyxiation	0.035	0.965
T66 Unspecified effects of radiation	0.035	0.965
T93 Sequelae of injuries of lower limb	0.035	0.965
S06 Intracranial injury	0.035	0.965
D68.0 Von Willebrand's disease	0.035	0.965
D73.9 Disease of spleen, unspecified	0.035	0.965
D73.8 Other diseases of spleen	0.035	0.965
D73.4 Cyst of spleen	0.035	0.965
D73.3 Abscess of spleen	0.035	0.965
D73.2 Chronic congestive splenomegaly	0.035	0.965
D73.1 Hypersplenism	0.035	0.965
S92 Fracture of foot, except ankle	0.035	0.965
T19 Foreign body in genito-urinary tract	0.035	0.965
T15 Foreign body on external eye	0.035	0.965
T16 Foreign body in ear	0.035	0.965
S99 Other and unspecified injuries of ankle and foot	0.035	0.965
S98 Traumatic amputation of ankle and foot	0.035	0.965
S97 Crushing injury of ankle and foot	0.035	0.965
S96 Injury of muscle and tendon at ankle and foot level	0.035	0.965
S95 Injury of blood vessels at ankle and foot level	0.035	0.965
S94 Injury of nerves at ankle and foot level	0.035	0.965
T65 Toxic effect of other and unspecified substances	0.034	0.965
T62 Toxic effect of other noxious substances eaten as food	0.034	0.965
T61 Toxic effect of noxious substances eaten as seafood	0.034	0.965
T60 Toxic effect of pesticides	0.034	0.965
T59 Toxic effect of other gases, fumes and vapours	0.034	0.965
T57 Toxic effect of other inorganic substances	0.034	0.965
T56 Toxic effect of metals	0.034	0.965
T54 Toxic effect of corrosive substances	0.034	0.965
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone	0.034	0.965
T52 Toxic effect of organic solvents	0.034	0.965
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants	0.034	0.965
T58 Toxic effect of carbon monoxide	0.034	0.965
T55 Toxic effect of soaps and detergents	0.034	0.965
S27 Injury of other and unspecified intrathoracic organs	0.034	0.966
T31 Burns classified according to extent of body surface involved	0.034	0.966
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.034	0.966
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.034	0.966
T13 Other injuries of lower limb, level unspecified	0.034	0.966
T11 Other injuries of upper limb, level unspecified	0.034	0.966
T09 Other injuries of spine and trunk, level unspecified	0.034	0.966
T12.X1 Fracture of lower limb, level unspecified (open)	0.034	0.966
T12.X0 Fracture of lower limb, level unspecified (closed)	0.034	0.966
T12 Fracture of lower limb, level unspecified	0.034	0.966
T10.X1 Fracture of upper limb, level unspecified (open)	0.034	0.966
T10.X0 Fracture of upper limb, level unspecified (closed)	0.034	0.966
T10 Fracture of upper limb, level unspecified	0.034	0.966
T08.X1 Fracture of spine, level unspecified (open)	0.034	0.966
T08.X0 Fracture of spine, level unspecified (closed)	0.034	0.966
T08 Fracture of spine, level unspecified	0.034	0.966
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.034	0.966
D80.8 Other immunodeficiencies with predominantly antibody defects	0.034	0.966
D80.7 Transient hypogammaglobulinaemia of infancy	0.034	0.966
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.034	0.966
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.034	0.966
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.034	0.966
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.034	0.966
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.034	0.966
D80.0 Hereditary hypogammaglobulinaemia	0.034	0.966
S79 Other and unspecified injuries of hip and thigh	0.034	0.966
T78.0 Anaphylactic shock due to adverse food reaction	0.034	0.966
# Top node	0.034	0.966
B49 Unspecified mycosis	0.034	0.966
T90.2 Sequelae of fracture of skull and facial bones	0.034	0.966
S72.31 Fracture of shaft of femur (open)	0.034	0.966
J44.8 Other specified chronic obstructive pulmonary disease	0.034	0.966
S09 Other and unspecified injuries of head	0.034	0.966
S19 Other and unspecified injuries of neck	0.033	0.966
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.033	0.967
B44 Aspergillosis	0.033	0.967
D68.6 Other Thrombophilia	0.033	0.967
D68.5 Primary Thrombophilia	0.033	0.967
D68.4 Acquired coagulation factor deficiency	0.033	0.967
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.033	0.967
D68.1 Hereditary factor XI deficiency	0.033	0.967
T32 Corrosions classified according to extent of body surface involved	0.033	0.967
T30 Burn and corrosion, body region unspecified	0.033	0.967
T29 Burns and corrosions of multiple body regions	0.033	0.967
S72.01 Fracture of neck of femur (open)	0.033	0.967
B35 Dermatophytosis	0.033	0.967
S91 Open wound of ankle and foot	0.033	0.967
T68 Hypothermia	0.033	0.967
D52.9 Folate deficiency anaemia, unspecified	0.033	0.967
T06 Other injuries involving multiple body regions, not elsewhere classified	0.032	0.967
T05 Traumatic amputations involving multiple body regions	0.032	0.967
T04 Crushing injuries involving multiple body regions	0.032	0.967
T03 Dislocations, sprains and strains involving multiple body regions	0.032	0.967
T02 Fractures involving multiple body regions	0.032	0.967
T01 Open wounds involving multiple body regions	0.032	0.967
T00 Superficial injuries involving multiple body regions	0.032	0.967
T07 Unspecified multiple injuries	0.032	0.967
T25 Burn and corrosion of ankle and foot	0.032	0.967
T24 Burn and corrosion of hip and lower limb, except ankle and foot	0.032	0.967
T23 Burn and corrosion of wrist and hand	0.032	0.967
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand	0.032	0.967
T21 Burn and corrosion of trunk	0.032	0.967
T20 Burn and corrosion of head and neck	0.032	0.967
T28 Burn and corrosion of other internal organs	0.032	0.967
T27 Burn and corrosion of respiratory tract	0.032	0.967
T26 Burn and corrosion confined to eye and adnexa	0.032	0.967
T35 Frostbite involving multiple body regions and unspecified frostbite	0.032	0.967
T34 Frostbite with tissue necrosis	0.032	0.967
T33 Superficial frostbite	0.032	0.967
S13.4 Sprain and strain of cervical spine	0.032	0.968
T63.4 Venom of other arthropods	0.032	0.968
T90.8 Sequelae of other specified injuries of head	0.032	0.968
T90.4 Sequelae of injury of eye and orbit	0.032	0.968
T90.3 Sequelae of injury of cranial nerves	0.032	0.968
T90.1 Sequelae of open wound of head	0.032	0.968
T90.0 Sequelae of superficial injury of head	0.032	0.968
D81.9 Combined immunodeficiency, unspecified	0.032	0.968
D81.8 Other combined immunodeficiencies	0.032	0.968
D81.7 Major histocompatibility complex class II deficiency	0.032	0.968
D81.6 Major histocompatibility complex class I deficiency	0.032	0.968
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.032	0.968
D81.4 Nezelof's syndrome	0.032	0.968
D81.3 Adenosine deaminase [ADA] deficiency	0.032	0.968
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.032	0.968
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.032	0.968
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.032	0.968
D82.9 Immunodeficiency associated with major defect, unspecified	0.032	0.968
D82.8 Immunodeficiency associated with other specified major defects	0.032	0.968
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.032	0.968
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.032	0.968
D82.2 Immunodeficiency with short-limbed stature	0.032	0.968
D82.1 Di George's syndrome	0.032	0.968
D82.0 Wiskott-Aldrich syndrome	0.032	0.968
D83.9 Common variable immunodeficiency, unspecified	0.032	0.968
D83.8 Other common variable immunodeficiencies	0.032	0.968
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.032	0.968
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.032	0.968
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.032	0.968
D84.9 Immunodeficiency, unspecified	0.032	0.968
D84.8 Other specified immunodeficiencies	0.032	0.968
D84.1 Defects in the complement system	0.032	0.968
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.032	0.968
B99-B99 Other infectious diseases	0.032	0.968
S70.8 Other superficial injuries of hip and thigh	0.032	0.968
S70.7 Multiple superficial injuries of hip and thigh	0.032	0.968
S70.1 Contusion of thigh	0.032	0.968
T18 Foreign body in alimentary tract	0.032	0.968
D63.0 Anaemia in neoplastic disease	0.032	0.968
O40 Polyhydramnios	0.032	0.968
J43.8 Other emphysema	0.032	0.968
J43.2 Centrilobular emphysema	0.032	0.968
J43.1 Panlobular emphysema	0.032	0.968
J43.0 MacLeod's syndrome	0.032	0.968
T51 Toxic effect of alcohol	0.032	0.968
A02 Other Salmonella infections	0.032	0.968
T78.1 Other adverse food reactions, not elsewhere classified	0.032	0.968
A07 Other protozoal intestinal diseases	0.032	0.968
A06 Amoebiasis	0.032	0.968
A05 Other bacterial foodborne intoxications	0.032	0.968
A03 Shigellosis	0.032	0.968
A01 Typhoid and paratyphoid fevers	0.032	0.968
A00 Cholera	0.032	0.968
S50-S59 Injuries to the elbow and forearm	0.032	0.968
B90-B94 Sequelae of infectious and parasitic diseases	0.032	0.968
T17.9 Foreign body in respiratory tract, part unspecified	0.031	0.968
D59.1 Other autoimmune haemolytic anaemias	0.031	0.968
S86.8 Injury of other muscles and tendons at lower leg level	0.031	0.968
T90.5 Sequelae of intracranial injury	0.031	0.968
D68.8 Other specified coagulation defects	0.031	0.969
S70.9 Superficial injury of hip and thigh, unspecified	0.031	0.969
B15-B19 Viral hepatitis	0.031	0.969
B37.8 Candidiasis of other sites	0.031	0.969
B37.7 Candidal septicaemia	0.031	0.969
B37.6 Candidal endocarditis	0.031	0.969
B37.5 Candidal meningitis	0.031	0.969
B37.4 Candidiasis of other urogenital sites	0.031	0.969
B37.2 Candidiasis of skin and nail	0.031	0.969
B37.1 Pulmonary candidiasis	0.031	0.969
T79.7 Traumatic subcutaneous emphysema	0.031	0.969
T94.0 Sequelae of injuries involving multiple body regions	0.031	0.969
T78.2 Anaphylactic shock, unspecified	0.031	0.969
B20-B24 Human immunodeficiency virus [HIV] disease	0.031	0.969
T17.2 Foreign body in pharynx	0.031	0.969
O32 Maternal care for known or suspected malpresentation of foetus	0.031	0.969
S28 Crushing injury of thorax and traumatic amputation of part of thorax	0.031	0.969
S26 Injury of heart	0.031	0.969
S25 Injury of blood vessels of thorax	0.031	0.969
S24 Injury of nerves and spinal cord at thorax level	0.031	0.969
S23 Dislocation, sprain and strain of joints and ligaments of thorax	0.031	0.969
S21 Open wound of thorax	0.031	0.969
S81 Open wound of lower leg	0.031	0.969

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations