TreeWAS – Variant ID: rs116909374

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	0.361	0.639
E04.2 Non-toxic multinodular goitre	0.572	0.428	0.000
E04 Other non-toxic goitre	0.570	0.428	0.001
E04.1 Non-toxic single thyroid nodule	0.539	0.461	0.000
E04.9 Non-toxic goitre, unspecified	0.535	0.465	0.000
E89.0 Postprocedural hypothyroidism	0.518	0.482	0.000
E00-E07 Disorders of thyroid gland	0.461	0.514	0.025
E03 Other hypothyroidism	0.193	0.526	0.281
E04.0 Non-toxic diffuse goitre	0.455	0.544	0.001
E05 Thyrotoxicosis [hyperthyroidism]	0.438	0.556	0.006
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.435	0.565	0.000
E04.8 Other specified non-toxic goitre	0.409	0.590	0.001
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.407	0.591	0.002
E05.9 Thyrotoxicosis, unspecified	0.379	0.620	0.001
E89.3 Postprocedural hypopituitarism	0.365	0.635	0.000
E89.2 Postprocedural hypoparathyroidism	0.361	0.639	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.330	0.651	0.018
E00 Congenital iodine-deficiency syndrome	0.330	0.651	0.018
E02 Subclinical iodine-deficiency hypothyroidism	0.330	0.651	0.018
E03.8 Other specified hypothyroidism	0.138	0.660	0.202
E03.5 Myxoedema coma	0.138	0.660	0.202
E03.4 Atrophy of thyroid (acquired)	0.138	0.660	0.202
E03.3 Postinfectious hypothyroidism	0.138	0.660	0.202
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.138	0.660	0.202
E03.1 Congenital hypothyroidism without goitre	0.138	0.660	0.202
E03.0 Congenital hypothyroidism with diffuse goitre	0.138	0.660	0.202
E06 Thyroiditis	0.307	0.675	0.018
E05.8 Other thyrotoxicosis	0.314	0.682	0.004
E05.5 Thyroid crisis or storm	0.314	0.682	0.004
E05.4 Thyrotoxicosis factitia	0.314	0.682	0.004
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.314	0.682	0.004
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.314	0.682	0.004
E07 Other disorders of thyroid	0.293	0.687	0.021
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.312	0.688	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.312	0.688	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.312	0.688	0.000
E89.5 Postprocedural testicular hypofunction	0.312	0.688	0.000
E89.4 Postprocedural ovarian failure	0.312	0.688	0.000
E89.1 Postprocedural hypoinsulinaemia	0.312	0.688	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.300	0.696	0.003
Chapter IV Endocrine, nutritional and metabolic diseases	0.261	0.734	0.005
E70-E90 Metabolic disorders	0.262	0.737	0.001
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.237	0.750	0.013
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.237	0.750	0.013
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.237	0.750	0.013
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.237	0.750	0.013
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.237	0.750	0.013
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.237	0.750	0.013
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.237	0.750	0.013
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.237	0.750	0.013
E07.8 Other specified disorders of thyroid	0.237	0.751	0.012
E06.9 Thyroiditis, unspecified	0.220	0.767	0.013
E06.5 Other chronic thyroiditis	0.220	0.767	0.013
E06.4 Drug-induced thyroiditis	0.220	0.767	0.013
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.220	0.767	0.013
E06.1 Subacute thyroiditis	0.220	0.767	0.013
E06.0 Acute thyroiditis	0.220	0.767	0.013
E07.1 Dyshormogenetic goitre	0.210	0.775	0.015
E07.0 Hypersecretion of calcitonin	0.210	0.775	0.015
E06.3 Autoimmune thyroiditis	0.196	0.790	0.013
E88 Other metabolic disorders	0.193	0.807	0.001
E85 Amyloidosis	0.188	0.811	0.001
E84 Cystic fibrosis	0.188	0.811	0.001
E79 Disorders of purine and pyrimidine metabolism	0.188	0.811	0.001
E77 Disorders of glycoprotein metabolism	0.188	0.811	0.001
E76 Disorders of glycosaminoglycan metabolism	0.188	0.811	0.001
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.188	0.811	0.001
E74 Other disorders of carbohydrate metabolism	0.188	0.811	0.001
E72 Other disorders of amino-acid metabolism	0.188	0.811	0.001
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.188	0.811	0.001
E70 Disorders of aromatic amino-acid metabolism	0.188	0.811	0.001
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.188	0.811	0.001
E73 Lactose intolerance	0.183	0.816	0.001
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.178	0.818	0.003
E50-E64 Other nutritional deficiencies	0.170	0.827	0.003
E40-E46 Malnutrition	0.166	0.830	0.004
E80 Disorders of porphyrin and bilirubin metabolism	0.162	0.837	0.001
E83 Disorders of mineral metabolism	0.153	0.846	0.000
E20-E35 Disorders of other endocrine glands	0.143	0.852	0.004
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.143	0.857	0.000
E65-E68 Obesity and other hyperalimentation	0.138	0.858	0.004
E88.9 Metabolic disorder, unspecified	0.138	0.861	0.001
E88.8 Other specified metabolic disorders	0.138	0.861	0.001
E88.3 Tumour lysis syndrome	0.138	0.861	0.001
E88.2 Lipomatosis, not elsewhere classified	0.138	0.861	0.001
E88.1 Lipodystrophy, not elsewhere classified	0.138	0.861	0.001
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.135	0.865	0.001
E70.8 Other disorders of aromatic amino-acid metabolism	0.135	0.865	0.001
E70.3 Albinism	0.135	0.865	0.001
E70.2 Disorders of tyrosine metabolism	0.135	0.865	0.001
E70.1 Other hyperphenylalaninaemias	0.135	0.865	0.001
E70.0 Classical phenylketonuria	0.135	0.865	0.001
E71.3 Disorders of fatty-acid metabolism	0.135	0.865	0.001
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.135	0.865	0.001
E71.1 Other disorders of branched-chain amino-acid metabolism	0.135	0.865	0.001
E71.0 Maple-syrup-urine disease	0.135	0.865	0.001
E72.9 Disorder of amino-acid metabolism, unspecified	0.135	0.865	0.001
E72.8 Other specified disorders of amino-acid metabolism	0.135	0.865	0.001
E72.5 Disorders of glycine metabolism	0.135	0.865	0.001
E72.4 Disorders of ornithine metabolism	0.135	0.865	0.001
E72.3 Disorders of lysine and hydroxylysine metabolism	0.135	0.865	0.001
E72.2 Disorders of urea cycle metabolism	0.135	0.865	0.001
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.135	0.865	0.001
E72.0 Disorders of amino-acid transport	0.135	0.865	0.001
E74.9 Disorder of carbohydrate metabolism, unspecified	0.135	0.865	0.001
E74.8 Other specified disorders of carbohydrate metabolism	0.135	0.865	0.001
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.135	0.865	0.001
E74.3 Other disorders of intestinal carbohydrate absorption	0.135	0.865	0.001
E74.2 Disorders of galactose metabolism	0.135	0.865	0.001
E74.1 Disorders of fructose metabolism	0.135	0.865	0.001
E74.0 Glycogen storage disease	0.135	0.865	0.001
E75.6 Lipid storage disorder, unspecified	0.135	0.865	0.001
E75.5 Other lipid storage disorders	0.135	0.865	0.001
E75.4 Neuronal ceroid lipofuscinosis	0.135	0.865	0.001
E75.3 Sphingolipidosis, unspecified	0.135	0.865	0.001
E75.2 Other sphingolipidosis	0.135	0.865	0.001
E75.1 Other gangliosidosis	0.135	0.865	0.001
E75.0 GM2 gangliosidosis	0.135	0.865	0.001
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.135	0.865	0.001
E76.8 Other disorders of glucosaminoglycan metabolism	0.135	0.865	0.001
E76.3 Mucopolysaccharidosis, unspecified	0.135	0.865	0.001
E76.2 Other mucopolysaccharidoses	0.135	0.865	0.001
E76.1 Mucopolysaccharidosis, type II	0.135	0.865	0.001
E76.0 Mucopolysaccharidosis, type I	0.135	0.865	0.001
E77.9 Disorder of glycoprotein metabolism, unspecified	0.135	0.865	0.001
E77.8 Other disorders of glycoprotein metabolism	0.135	0.865	0.001
E77.1 Defects in glycoprotein degradation	0.135	0.865	0.001
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.135	0.865	0.001
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.135	0.865	0.001
E79.8 Other disorders of purine and pyrimidine metabolism	0.135	0.865	0.001
E79.1 Lesch-Nyhan syndrome	0.135	0.865	0.001
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.135	0.865	0.001
E84.9 Cystic fibrosis, unspecified	0.135	0.865	0.001
E84.8 Cystic fibrosis with other manifestations	0.135	0.865	0.001
E84.1 Cystic fibrosis with intestinal manifestations	0.135	0.865	0.001
E84.0 Cystic fibrosis with pulmonary manifestations	0.135	0.865	0.001
E85.9 Amyloidosis, unspecified	0.135	0.865	0.001
E85.8 Other amyloidosis	0.135	0.865	0.001
E85.4 Organ-limited amyloidosis	0.135	0.865	0.001
E85.3 Secondary systemic amyloidosis	0.135	0.865	0.001
E85.2 Heredofamilial amyloidosis, unspecified	0.135	0.865	0.001
E85.1 Neuropathic heredofamilial amyloidosis	0.135	0.865	0.001
E85.0 Nonneuropathic heredofamilial amyloidosis	0.135	0.865	0.001
E07.9 Disorder of thyroid, unspecified	0.113	0.868	0.019
E73.8 Other lactose intolerance	0.131	0.868	0.001
E73.1 Secondary lactase deficiency	0.131	0.868	0.001
E73.0 Congenital lactase deficiency	0.131	0.868	0.001
E15 Nondiabetic hypoglycaemic coma	0.128	0.870	0.002
E22 Hyperfunction of pituitary gland	0.127	0.871	0.002
E73.9 Lactose intolerance, unspecified	0.127	0.873	0.001
E61 Deficiency of other nutrient elements	0.124	0.874	0.002
E64 Sequelae of malnutrition and other nutritional deficiencies	0.122	0.876	0.002
E63 Other nutritional deficiencies	0.122	0.876	0.002
E56 Other vitamin deficiencies	0.122	0.876	0.002
E51 Thiamine deficiency	0.122	0.876	0.002
E50 Vitamin A deficiency	0.122	0.876	0.002
E60 Dietary zinc deficiency	0.122	0.876	0.002
E59 Dietary selenium deficiency	0.122	0.876	0.002
E58 Dietary calcium deficiency	0.122	0.876	0.002
E54 Ascorbic acid deficiency	0.122	0.876	0.002
E52 Niacin deficiency [pellagra]	0.122	0.876	0.002
E44 Protein-energy malnutrition of moderate and mild degree	0.119	0.878	0.003
E45 Retarded development following protein-energy malnutrition	0.119	0.878	0.003
E43 Unspecified severe protein-energy malnutrition	0.119	0.878	0.003
E42 Marasmic kwashiorkor	0.119	0.878	0.003
E41 Nutritional marasmus	0.119	0.878	0.003
E40 Kwashiorkor	0.119	0.878	0.003
E16 Other disorders of pancreatic internal secretion	0.119	0.879	0.002
E83.1 Disorders of iron metabolism	0.120	0.880	0.000
E55 Vitamin D deficiency	0.117	0.881	0.002
E80.7 Disorder of bilirubin metabolism, unspecified	0.116	0.883	0.001
E80.6 Other disorders of bilirubin metabolism	0.116	0.883	0.001
E80.5 Crigler-Najjar syndrome	0.116	0.883	0.001
E80.3 Defects of catalase and peroxydase	0.116	0.883	0.001
E80.2 Other porphyria	0.116	0.883	0.001
E80.1 Porphyria cutanea tarda	0.116	0.883	0.001
E80.0 Hereditary erythropoietic porphyria	0.116	0.883	0.001
E53 Deficiency of other B group vitamins	0.109	0.889	0.002
E83.9 Disorder of mineral metabolism, unspecified	0.110	0.890	0.000
E83.8 Other disorders of mineral metabolism	0.110	0.890	0.000
E83.2 Disorders of zinc metabolism	0.110	0.890	0.000
E83.0 Disorders of copper metabolism	0.110	0.890	0.000
E26 Hyperaldosteronism	0.107	0.890	0.003
E24 Cushing's syndrome	0.106	0.891	0.003
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.108	0.891	0.001
E65 Localised adiposity	0.106	0.891	0.003
E35 Disorders of endocrine glands in diseases classified elsewhere	0.103	0.894	0.003
E34 Other endocrine disorders	0.103	0.894	0.003
E32 Diseases of thymus	0.103	0.894	0.003
E31 Polyglandular dysfunction	0.103	0.894	0.003
E30 Disorders of puberty, not elsewhere classified	0.103	0.894	0.003
E29 Testicular dysfunction	0.103	0.894	0.003
E25 Adrenogenital disorders	0.103	0.894	0.003
E20 Hypoparathyroidism	0.103	0.894	0.003
E22.0 Acromegaly and pituitary gigantism	0.102	0.897	0.001
E67 Other hyperalimentation	0.099	0.898	0.003
E68 Sequelae of hyperalimentation	0.099	0.898	0.003
E83.5 Disorders of calcium metabolism	0.102	0.898	0.000
E46 Unspecified protein-energy malnutrition	0.098	0.899	0.003
E83.4 Disorders of magnesium metabolism	0.098	0.902	0.000
E22.1 Hyperprolactinaemia	0.095	0.904	0.001
E22.9 Hyperfunction of pituitary gland, unspecified	0.091	0.907	0.002
E22.8 Other hyperfunction of pituitary gland	0.091	0.907	0.002
E61.1 Iron deficiency	0.091	0.907	0.001
E80.4 Gilbert's syndrome	0.090	0.909	0.001
E61.9 Deficiency of nutrient element, unspecified	0.089	0.909	0.002
E61.8 Deficiency of other specified nutrient elements	0.089	0.909	0.002
E61.7 Deficiency of multiple nutrient elements	0.089	0.909	0.002
E61.6 Vanadium deficiency	0.089	0.909	0.002
E61.5 Molybdenum deficiency	0.089	0.909	0.002
E61.4 Chromium deficiency	0.089	0.909	0.002
E61.3 Manganese deficiency	0.089	0.909	0.002
E61.2 Magnesium deficiency	0.089	0.909	0.002
E61.0 Copper deficiency	0.089	0.909	0.002
E50.9 Vitamin A deficiency, unspecified	0.088	0.911	0.002
E50.8 Other manifestations of vitamin A deficiency	0.088	0.911	0.002
E50.7 Other ocular manifestations of vitamin A deficiency	0.088	0.911	0.002
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.088	0.911	0.002
E50.5 Vitamin A deficiency with night blindness	0.088	0.911	0.002
E50.4 Vitamin A deficiency with keratomalacia	0.088	0.911	0.002
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.088	0.911	0.002
E50.2 Vitamin A deficiency with corneal xerosis	0.088	0.911	0.002
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.088	0.911	0.002
E50.0 Vitamin A deficiency with conjunctival xerosis	0.088	0.911	0.002
E51.9 Thiamine deficiency, unspecified	0.088	0.911	0.002
E51.8 Other manifestations of thiamine deficiency	0.088	0.911	0.002
E51.2 Wernicke's encephalopathy	0.088	0.911	0.002
E51.1 Beriberi	0.088	0.911	0.002
E56.9 Vitamin deficiency, unspecified	0.088	0.911	0.002
E56.8 Deficiency of other vitamins	0.088	0.911	0.002
E56.1 Deficiency of vitamin K	0.088	0.911	0.002
E56.0 Deficiency of vitamin E	0.088	0.911	0.002
E63.9 Nutritional deficiency, unspecified	0.088	0.911	0.002
E63.8 Other specified nutritional deficiencies	0.088	0.911	0.002
E63.1 Imbalance of constituents of food intake	0.088	0.911	0.002
E63.0 Essential fatty acid [EFA] deficiency	0.088	0.911	0.002
E64.9 Sequelae of unspecified nutritional deficiency	0.088	0.911	0.002
E64.8 Sequelae of other nutritional deficiencies	0.088	0.911	0.002
E64.3 Sequelae of rickets	0.088	0.911	0.002
E64.2 Sequelae of vitamin C deficiency	0.088	0.911	0.002
E64.1 Sequelae of vitamin A deficiency	0.088	0.911	0.002
E64.0 Sequelae of protein-energy malnutrition	0.088	0.911	0.002
E44.1 Mild protein-energy malnutrition	0.086	0.912	0.002
E44.0 Moderate protein-energy malnutrition	0.086	0.912	0.002
E83.3 Disorders of phosphorus metabolism	0.087	0.913	0.001
E16.9 Disorder of pancreatic internal secretion, unspecified	0.085	0.913	0.002
E16.8 Other specified disorders of pancreatic internal secretion	0.085	0.913	0.002
E16.4 Abnormal secretion of gastrin	0.085	0.913	0.002
E16.3 Increased secretion of glucagon	0.085	0.913	0.002
E16.1 Other hypoglycaemia	0.085	0.913	0.002
E16.0 Drug-induced hypoglycaemia without coma	0.085	0.913	0.002
E28 Ovarian dysfunction	0.082	0.914	0.004
E55.0 Rickets, active	0.084	0.915	0.002
E23 Hypofunction and other disorders of pituitary gland	0.081	0.915	0.004
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.082	0.915	0.003
E26.0 Primary hyperaldosteronism	0.082	0.916	0.002
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.082	0.918	0.001
E24.9 Cushing's syndrome, unspecified	0.080	0.918	0.002
E55.9 Vitamin D deficiency, unspecified	0.079	0.920	0.001
E53.9 Vitamin B deficiency, unspecified	0.078	0.921	0.002
E53.1 Pyridoxine deficiency	0.078	0.921	0.002
E53.0 Riboflavin deficiency	0.078	0.921	0.002
E26.9 Hyperaldosteronism, unspecified	0.077	0.921	0.002
E26.8 Other hyperaldosteronism	0.077	0.921	0.002
E26.1 Secondary hyperaldosteronism	0.077	0.921	0.002
E24.8 Other Cushing's syndrome	0.076	0.921	0.002
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.076	0.921	0.002
E24.3 Ectopic ACTH syndrome	0.076	0.921	0.002
E24.2 Drug-induced Cushing's syndrome	0.076	0.921	0.002
E24.1 Nelson's syndrome	0.076	0.921	0.002
E24.0 Pituitary-dependent Cushing's disease	0.076	0.921	0.002
E16.2 Hypoglycaemia, unspecified	0.076	0.923	0.001
E86 Volume depletion	0.076	0.923	0.000
E20.9 Hypoparathyroidism, unspecified	0.074	0.924	0.002
E20.8 Other hypoparathyroidism	0.074	0.924	0.002
E20.1 Pseudohypoparathyroidism	0.074	0.924	0.002
E20.0 Idiopathic hypoparathyroidism	0.074	0.924	0.002
E25.9 Adrenogenital disorder, unspecified	0.074	0.924	0.002
E25.8 Other adrenogenital disorders	0.074	0.924	0.002
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.074	0.924	0.002
E29.9 Testicular dysfunction, unspecified	0.074	0.924	0.002
E29.8 Other testicular dysfunction	0.074	0.924	0.002
E29.1 Testicular hypofunction	0.074	0.924	0.002
E29.0 Testicular hyperfunction	0.074	0.924	0.002
E30.9 Disorder of puberty, unspecified	0.074	0.924	0.002
E30.8 Other disorders of puberty	0.074	0.924	0.002
E30.1 Precocious puberty	0.074	0.924	0.002
E30.0 Delayed puberty	0.074	0.924	0.002
E31.9 Polyglandular dysfunction, unspecified	0.074	0.924	0.002
E31.8 Other polyglandular dysfunction	0.074	0.924	0.002
E31.1 Polyglandular hyperfunction	0.074	0.924	0.002
E31.0 Autoimmune polyglandular failure	0.074	0.924	0.002
E32.9 Disease of thymus, unspecified	0.074	0.924	0.002
E32.8 Other diseases of thymus	0.074	0.924	0.002
E32.1 Abscess of thymus	0.074	0.924	0.002
E32.0 Persistent hyperplasia of thymus	0.074	0.924	0.002
E34.9 Endocrine disorder, unspecified	0.074	0.924	0.002
E34.8 Other specified endocrine disorders	0.074	0.924	0.002
E34.5 Androgen resistance syndrome	0.074	0.924	0.002
E34.4 Constitutional tall stature	0.074	0.924	0.002
E34.3 Short stature, not elsewhere classified	0.074	0.924	0.002
E34.2 Ectopic hormone secretion, not elsewhere classified	0.074	0.924	0.002
E34.1 Other hypersecretion of intestinal hormones	0.074	0.924	0.002
E34.0 Carcinoid syndrome	0.074	0.924	0.002
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.074	0.924	0.002
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.074	0.924	0.002
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.074	0.924	0.002
E27 Other disorders of adrenal gland	0.071	0.925	0.004
E67.8 Other specified hyperalimentation	0.071	0.927	0.002
E67.3 Hypervitaminosis D	0.071	0.927	0.002
E67.2 Megavitamin-B6 syndrome	0.071	0.927	0.002
E67.1 Hypercarotenaemia	0.071	0.927	0.002
E67.0 Hypervitaminosis A	0.071	0.927	0.002
E78.4 Other hyperlipidaemia	0.069	0.931	0.000
E53.8 Deficiency of other specified B group vitamins	0.064	0.934	0.001
E78.8 Other disorders of lipoprotein metabolism	0.063	0.937	0.000
E23.2 Diabetes insipidus	0.059	0.938	0.003
E28.9 Ovarian dysfunction, unspecified	0.059	0.938	0.003
E28.8 Other ovarian dysfunction	0.059	0.938	0.003
E28.3 Primary ovarian failure	0.059	0.938	0.003
E28.1 Androgen excess	0.059	0.938	0.003
E28.0 Oestrogen excess	0.059	0.938	0.003
E23.7 Disorder of pituitary gland, unspecified	0.059	0.939	0.003
E23.6 Other disorders of pituitary gland	0.059	0.939	0.003
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.059	0.939	0.003
E23.1 Drug-induced hypopituitarism	0.059	0.939	0.003
E21.5 Disorder of parathyroid gland, unspecified	0.059	0.939	0.002
E21.4 Other specified disorders of parathyroid gland	0.059	0.939	0.002
E21.2 Other hyperparathyroidism	0.059	0.939	0.002
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.059	0.939	0.002
E78.2 Mixed hyperlipidaemia	0.060	0.939	0.000
E78.6 Lipoprotein deficiency	0.059	0.941	0.001
E78.3 Hyperchylomicronaemia	0.059	0.941	0.001
E78.1 Pure hyperglyceridaemia	0.059	0.941	0.001
E78.9 Disorder of lipoprotein metabolism, unspecified	0.058	0.941	0.000
E27.8 Other specified disorders of adrenal gland	0.052	0.945	0.003
E27.9 Disorder of adrenal gland, unspecified	0.051	0.946	0.003
E27.5 Adrenomedullary hyperfunction	0.051	0.946	0.003
E27.3 Drug-induced adrenocortical insufficiency	0.051	0.946	0.003
E27.2 Addisonian crisis	0.051	0.946	0.003
E27.0 Other adrenocortical overactivity	0.051	0.946	0.003
E10-E14 Diabetes mellitus	0.050	0.947	0.003
E21.3 Hyperparathyroidism, unspecified	0.050	0.948	0.002
E21.0 Primary hyperparathyroidism	0.050	0.948	0.002
E87 Other disorders of fluid, electrolyte and acid-base balance	0.049	0.951	0.001
E27.1 Primary adrenocortical insufficiency	0.042	0.955	0.003
E13 Other specified diabetes mellitus	0.041	0.957	0.002
E87.5 Hyperkalaemia	0.042	0.958	0.000
E28.2 Polycystic ovarian syndrome	0.038	0.958	0.004
E87.7 Fluid overload	0.041	0.959	0.000
E23.0 Hypopituitarism	0.036	0.961	0.004
E27.4 Other and unspecified adrenocortical insufficiency	0.035	0.962	0.004
E12 Malnutrition-related diabetes mellitus	0.036	0.962	0.003
E13.9 Without complications	0.035	0.964	0.001
E87.4 Mixed disorder of acid-base balance	0.035	0.964	0.001
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.033	0.967	0.001
E66 Obesity	0.028	0.968	0.004
E13.8 With unspecified complications	0.030	0.969	0.002
E13.7 With multiple complications	0.030	0.969	0.002
E13.6 With other specified complications	0.030	0.969	0.002
E13.5 With peripheral circulatory complications	0.030	0.969	0.002
E13.4 With neurological complications	0.030	0.969	0.002
E13.3 With ophthalmic complications	0.030	0.969	0.002
E13.2 With renal complications	0.030	0.969	0.002
E13.1 With ketoacidosis	0.030	0.969	0.002
E13.0 With coma	0.030	0.969	0.002
E87.3 Alkalosis	0.030	0.970	0.001
E12.9 Without complications	0.026	0.972	0.002
E12.8 With unspecified complications	0.026	0.972	0.002
E12.7 With multiple complications	0.026	0.972	0.002
E12.6 With other specified complications	0.026	0.972	0.002
E12.5 With peripheral circulatory complications	0.026	0.972	0.002
E12.4 With neurological complications	0.026	0.972	0.002
E12.3 With ophthalmic complications	0.026	0.972	0.002
E12.2 With renal complications	0.026	0.972	0.002
E12.1 With ketoacidosis	0.026	0.972	0.002
E12.0 With coma	0.026	0.972	0.002
E87.6 Hypokalaemia	0.024	0.975	0.000
E87.0 Hyperosmolality and hypernatraemia	0.023	0.976	0.001
E66.2 Extreme obesity with alveolar hypoventilation	0.021	0.977	0.003
E66.1 Drug-induced obesity	0.021	0.977	0.003
E66.0 Obesity due to excess calories	0.021	0.977	0.003
E14 Unspecified diabetes mellitus	0.018	0.978	0.004
G62.9 Polyneuropathy, unspecified	0.017	0.983	0.000
E87.1 Hypo-osmolality and hyponatraemia	0.016	0.984	0.001
E14.8 With unspecified complications	0.013	0.984	0.003
E14.7 With multiple complications	0.013	0.984	0.003
E14.6 With other specified complications	0.013	0.984	0.003
E14.5 With peripheral circulatory complications	0.013	0.984	0.003
E14.4 With neurological complications	0.013	0.984	0.003
E14.2 Withrenal complications	0.013	0.984	0.003
E14.1 With ketoacidosis	0.013	0.984	0.003
E14.0 With coma	0.013	0.984	0.003
C50.4 Upper-outer quadrant of breast	0.000	0.985	0.015
C73 Malignant neoplasm of thyroid gland	0.015	0.985	0.000
G35 Multiple sclerosis	0.015	0.985	0.000
E14.3 With ophthalmic complications	0.011	0.986	0.003
E10 Insulin-dependent diabetes mellitus	0.011	0.987	0.003
C50 Malignant neoplasm of breast	0.000	0.988	0.012
E11 Non-insulin-dependent diabetes mellitus	0.010	0.988	0.001
G62 Other polyneuropathies	0.011	0.988	0.000
C50.3 Lower-inner quadrant of breast	0.000	0.990	0.010
C50.5 Lower-outer quadrant of breast	0.000	0.990	0.010
G35-G37 Demyelinating diseases of the central nervous system	0.010	0.990	0.000
C50.9 Breast, unspecified	0.000	0.990	0.010
E10.8 With unspecified complications	0.008	0.990	0.002
E10.7 With multiple complications	0.008	0.990	0.002
E10.6 With other specified complications	0.008	0.990	0.002
E10.2 With renal complications	0.008	0.990	0.002
E10.0 With coma	0.008	0.990	0.002
E87.2 Acidosis	0.008	0.990	0.002
E10.4 With neurological complications	0.008	0.990	0.002
C50.0 Nipple and areola	0.000	0.990	0.010
E10.5 With peripheral circulatory complications	0.008	0.990	0.002
C50.6 Axillary tail of breast	0.000	0.991	0.009
C50.8 Overlapping lesion of breast	0.000	0.991	0.009
E11.0 With coma	0.008	0.991	0.001
E11.8 With unspecified complications	0.008	0.991	0.001
E11.7 With multiple complications	0.008	0.991	0.001
G62.2 Polyneuropathy due to other toxic agents	0.008	0.991	0.000
G62.1 Alcoholic polyneuropathy	0.008	0.991	0.000
G62.0 Drug-induced polyneuropathy	0.008	0.991	0.000
E11.1 With ketoacidosis	0.008	0.991	0.001
E66.8 Other obesity	0.004	0.992	0.005
G37 Other demyelinating diseases of central nervous system	0.008	0.992	0.000
E11.6 With other specified complications	0.007	0.992	0.001
G62.8 Other specified polyneuropathies	0.008	0.992	0.000
E11.2 With renal complications	0.007	0.992	0.001
C50.1 Central portion of breast	0.000	0.992	0.008
E11.4 With neurological complications	0.007	0.992	0.001
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.008	0.992	0.000
E10.1 With ketoacidosis	0.005	0.992	0.003
G36 Other acute disseminated demyelination	0.007	0.992	0.000
E10.3 With ophthalmic complications	0.005	0.993	0.002
G37.9 Demyelinating disease of central nervous system, unspecified	0.007	0.993	0.000
E11.5 With peripheral circulatory complications	0.006	0.993	0.001
G61 Inflammatory polyneuropathy	0.006	0.993	0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.006	0.994	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.006	0.994	0.000
G37.5 Concentric sclerosis [Balo]	0.006	0.994	0.000
G37.4 Subacute necrotising myelitis	0.006	0.994	0.000
G37.2 Central pontine myelinolysis	0.006	0.994	0.000
G37.1 Central demyelination of corpus callosum	0.006	0.994	0.000
G37.0 Diffuse sclerosis	0.006	0.994	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.006	0.994	0.000
C50.2 Upper-inner quadrant of breast	0.000	0.994	0.006
E14.9 Without complications	0.002	0.994	0.004
G60 Hereditary and idiopathic neuropathy	0.006	0.994	0.000
G64 Other disorders of peripheral nervous system	0.006	0.994	0.000
G36.9 Acute disseminated demyelination, unspecified	0.005	0.994	0.000
G36.8 Other specified acute disseminated demyelination	0.005	0.994	0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.005	0.994	0.000
G36.0 Neuromyelitis optica [Devic]	0.005	0.994	0.000
G61.8 Other inflammatory polyneuropathies	0.005	0.994	0.000
G63 Polyneuropathy in diseases classified elsewhere	0.005	0.994	0.000
C50-C50 Malignant neoplasm of breast	0.000	0.995	0.005
M79.67 Pain in limb (Ankle and foot)	0.005	0.995	0.000
G61.9 Inflammatory polyneuropathy, unspecified	0.005	0.995	0.000
G61.1 Serum neuropathy	0.005	0.995	0.000
R03.0 Elevated blood-pressure reading, without diagnosis of hypertension	0.000	0.995	0.005
G61.0 Guillain-Barre syndrome	0.005	0.995	0.000
C75 Malignant neoplasm of other endocrine glands and related structures	0.005	0.995	0.000
C74 Malignant neoplasm of adrenal gland	0.005	0.995	0.000
E11.3 With ophthalmic complications	0.004	0.995	0.001
Chapter VI Diseases of the nervous system	0.005	0.995	0.000
G60.9 Hereditary and idiopathic neuropathy, unspecified	0.004	0.995	0.000
G60.8 Other hereditary and idiopathic neuropathies	0.004	0.995	0.000
G60.3 Idiopathic progressive neuropathy	0.004	0.995	0.000
G60.2 Neuropathy in association with hereditary ataxia	0.004	0.995	0.000
G60.1 Refsum's disease	0.004	0.995	0.000
G60.0 Hereditary motor and sensory neuropathy	0.004	0.995	0.000
E11.9 Without complications	0.004	0.995	0.000
E10.9 Without complications	0.003	0.996	0.001
G30-G32 Other degenerative diseases of the nervous system	0.004	0.996	0.000
K20 Oesophagitis	0.004	0.996	0.000
G63.8 Polyneuropathy in other diseases classified elsewhere	0.004	0.996	0.000
G63.6 Polyneuropathy in other musculoskeletal disorders	0.004	0.996	0.000
G63.5 Polyneuropathy in systemic connective tissue disorders	0.004	0.996	0.000
G63.4 Polyneuropathy in nutritional deficiency	0.004	0.996	0.000
G63.3 Polyneuropathy in other endocrine and metabolic diseases	0.004	0.996	0.000
G63.1 Polyneuropathy in neoplastic disease	0.004	0.996	0.000
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere	0.004	0.996	0.000
E78.5 Hyperlipidaemia, unspecified	0.002	0.996	0.002
O63.1 Prolonged second stage (of labour)	0.000	0.996	0.004
R03.1 Nonspecific low blood-pressure reading	0.000	0.996	0.004
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.004	0.996	0.000
G31.9 Degenerative disease of nervous system, unspecified	0.004	0.996	0.000
G63.2 Diabetic polyneuropathy	0.004	0.996	0.000
C74.9 Adrenal gland, unspecified	0.004	0.996	0.000
C74.1 Medulla of adrenal gland	0.004	0.996	0.000
C74.0 Cortex of adrenal gland	0.004	0.996	0.000
C75.9 Endocrine gland, unspecified	0.004	0.996	0.000
C75.8 Pluriglandular involvement, unspecified	0.004	0.996	0.000
C75.5 Aortic body and other paraganglia	0.004	0.996	0.000
C75.4 Carotid body	0.004	0.996	0.000
C75.3 Pineal gland	0.004	0.996	0.000
C75.2 Craniopharyngeal duct	0.004	0.996	0.000
C75.1 Pituitary gland	0.004	0.996	0.000
C75.0 Parathyroid gland	0.004	0.996	0.000
R03 Abnormal blood-pressure reading, without diagnosis	0.000	0.996	0.004

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations