TreeWAS – Variant ID: rs12261843

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
I10 Essential (primary) hypertension	0.000	0.905	0.095
H74.4 Polyp of middle ear	0.080	0.920	0.000
H74 Other disorders of middle ear and mastoid	0.076	0.924	0.000
H74.8 Other specified disorders of middle ear and mastoid	0.066	0.934	0.000
H74.2 Discontinuity and dislocation of ear ossicles	0.064	0.936	0.000
H74.0 Tympanosclerosis	0.063	0.937	0.000
H65-H75 Diseases of middle ear and mastoid	0.061	0.939	0.000
H66 Suppurative and unspecified otitis media	0.058	0.942	0.000
H74.1 Adhesive middle ear disease	0.058	0.942	0.000
I10-I15 Hypertensive diseases	0.000	0.943	0.057
H71 Cholesteatoma of middle ear	0.056	0.944	0.000
H66.3 Other chronic suppurative otitis media	0.056	0.944	0.000
I15 Secondary hypertension	0.000	0.944	0.056
I15.1 Hypertension secondary to other renal disorders	0.000	0.945	0.055
H66.2 Chronic atticoantral suppurative otitis media	0.053	0.947	0.000
H74.3 Other acquired abnormalities of ear ossicles	0.051	0.949	0.000
H66.4 Suppurative otitis media, unspecified	0.049	0.951	0.000
H73 Other disorders of tympanic membrane	0.048	0.952	0.000
H65 Nonsuppurative otitis media	0.047	0.953	0.000
H74.9 Disorder of middle ear and mastoid, unspecified	0.047	0.953	0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.044	0.956	0.000
H68 Eustachian salpingitis and obstruction	0.044	0.956	0.000
H67 Otitis media in diseases classified elsewhere	0.044	0.956	0.000
I15.9 Seconday hypertension, unspecified	0.000	0.956	0.043
H65.4 Other chronic nonsuppurative otitis media	0.043	0.957	0.000
H66.1 Chronic tubotympanic suppurative otitis media	0.043	0.957	0.000
H69 Other disorders of Eustachian tube	0.043	0.957	0.000
H73.1 Chronic myringitis	0.041	0.959	0.000
I15.2 Hypertension secondary to endocrine disorders	0.000	0.960	0.040
I15.0 Renovascular hypertension	0.000	0.960	0.040
H65.3 Chronic mucoid otitis media	0.039	0.961	0.000
I13 Hypertensive heart and renal disease	0.000	0.964	0.035
I15.8 Other secondary hypertension	0.000	0.965	0.035
H73.9 Disorder of tympanic membrane, unspecified	0.035	0.965	0.000
H73.0 Acute myringitis	0.035	0.965	0.000
I12 Hypertensive renal disease	0.000	0.965	0.035
H70 Mastoiditis and related conditions	0.034	0.966	0.000
H65.1 Other acute nonsuppurative otitis media	0.034	0.966	0.000
H66.0 Acute suppurative otitis media	0.034	0.966	0.000
H65.0 Acute serous otitis media	0.033	0.966	0.000
I11 Hypertensive heart disease	0.000	0.968	0.032
H69.9 Eustachian tube disorder, unspecified	0.032	0.968	0.000
H67.8 Otitis media in other diseases classified elsewhere	0.032	0.968	0.000
H67.1 Otitis media in viral diseases classified elsewhere	0.032	0.968	0.000
H67.0 Otitis media in bacterial diseases classified elsewhere	0.032	0.968	0.000
H68.1 Obstruction of Eustachian tube	0.032	0.968	0.000
H68.0 Eustachian salpingitis	0.032	0.968	0.000
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere	0.032	0.968	0.000
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere	0.032	0.968	0.000
H73.8 Other specified disorders of tympanic membrane	0.032	0.968	0.000
H69.0 Patulous Eustachian tube	0.031	0.969	0.000
H65.2 Chronic serous otitis media	0.031	0.969	0.000
I12.9 Hypertensive renal disease without renal failure	0.000	0.971	0.029
H69.8 Other specified disorders of Eustachian tube	0.028	0.972	0.000
I13.9 Hypertensive heart and renal disease, unspecified	0.000	0.974	0.025
I13.1 Hypertensive heart and renal disease with renal failure	0.000	0.974	0.025
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.000	0.974	0.025
H70.2 Petrositis	0.025	0.975	0.000
H70.0 Acute mastoiditis	0.025	0.975	0.000
H70.9 Mastoiditis, unspecified	0.023	0.977	0.000
H70.8 Other mastoiditis and related conditions	0.023	0.977	0.000
I11.9 Hypertensive heart disease without (congestive) heart failure	0.000	0.977	0.023
K50.9 Crohn's disease, unspecified	0.022	0.978	0.000
H70.1 Chronic mastoiditis	0.020	0.979	0.000
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.001	0.980	0.020
K50 Crohn's disease [regional enteritis]	0.016	0.984	0.000
I11.0 Hypertensive heart disease with (congestive) heart failure	0.000	0.984	0.015
C61 Malignant neoplasm of prostate	0.015	0.985	0.000
K50.8 Other Crohn's disease	0.015	0.985	0.000
H72 Perforation of tympanic membrane	0.015	0.985	0.000
K50.0 Crohn's disease of small intestine	0.013	0.987	0.000
K50.1 Crohn's disease of large intestine	0.011	0.989	0.000
H66.9 Otitis media, unspecified	0.011	0.989	0.000
O26.9 Pregnancy-related condition, unspecified	0.011	0.989	0.000
H72.9 Perforation of tympanic membrane, unspecified	0.011	0.989	0.000
H65.9 Nonsuppurative otitis media, unspecified	0.010	0.990	0.000
D48.5 Skin	0.010	0.990	0.000
H72.1 Attic perforation of tympanic membrane	0.009	0.991	0.000
H72.2 Other marginal perforations of tympanic membrane	0.009	0.991	0.000
S82.80 Fractures of other parts of lower leg (closed)	0.008	0.992	0.000
Chapter VIII Diseases of the ear and mastoid process	0.008	0.992	0.000
I12.0 Hypertensive renal disease with renal failure	0.000	0.992	0.008
S06.60 Traumatic subarachnoid haemorrhage (without open intracranial wound)	0.000	0.992	0.008
H72.0 Central perforation of tympanic membrane	0.008	0.992	0.000
H06.2 Dysthyroid exophthalmos	0.000	0.993	0.007
H60.8 Other otitis externa	0.007	0.993	0.000
H60 Otitis externa	0.007	0.993	0.000
H60-H62 Diseases of external ear	0.007	0.993	0.000
S06.6 Traumatic subarachnoid haemorrhage	0.000	0.993	0.007
C60-C63 Malignant neoplasms of male genital organs	0.006	0.994	0.000
N50.1 Vascular disorders of male genital organs	0.000	0.994	0.006
H60.4 Cholesteatoma of external ear	0.006	0.994	0.000
S06.20 Diffuse brain injury (without open intracranial wound)	0.000	0.994	0.006
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites	0.006	0.994	0.000
D48.0 Bone and articular cartilage	0.006	0.994	0.000
H60.2 Malignant otitis externa	0.006	0.994	0.000
H72.8 Other perforations of tympanic membrane	0.006	0.994	0.000
S06.2 Diffuse brain injury	0.000	0.994	0.006
S06 Intracranial injury	0.000	0.994	0.006
S06.40 Epidural haemorrhage (without open intracranial wound)	0.000	0.994	0.006
S06.4 Epidural haemorrhage	0.000	0.994	0.006
C63 Malignant neoplasm of other and unspecified male genital organs	0.005	0.994	0.000
H60.0 Abscess of external ear	0.005	0.995	0.000
H60.1 Cellulitis of external ear	0.005	0.995	0.000
H60.5 Acute otitis externa, non-infective	0.005	0.995	0.000
S06.8 Other intracranial injuries	0.000	0.995	0.005
O26 Maternal care for other conditions predominantly related to pregnancy	0.005	0.995	0.000
M88.90 Paget's disease of bone, unspecified (Multiple sites)	0.000	0.995	0.005
H62 Disorders of external ear in diseases classified elsewhere	0.005	0.995	0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk	0.005	0.995	0.000
S06.61 Traumatic subarachnoid haemorrhage (with open intracranial wound)	0.000	0.995	0.005
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.005	0.995	0.000
C63.2 Scrotum	0.005	0.995	0.000
Q21.1 Atrial septal defect	0.000	0.995	0.005
M89.94 Disorder of bone, unspecified (Hand)	0.005	0.995	0.000
S06.80 Other intracranial injuries (without open intracranial wound)	0.000	0.995	0.005
M89.9 Disorder of bone, unspecified	0.005	0.995	0.000
S06.3 Focal brain injury	0.000	0.995	0.005
C60 Malignant neoplasm of penis	0.005	0.995	0.000
O26.7 Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium	0.005	0.995	0.000
H60.3 Other infective otitis externa	0.005	0.995	0.000
D48.6 Breast	0.005	0.995	0.000
D48.4 Peritoneum	0.005	0.995	0.000
D48.3 Retroperitoneum	0.005	0.995	0.000
R02 Gangrene, not elsewhere classified	0.000	0.995	0.005
S06.21 Diffuse brain injury (with open intracranial wound)	0.000	0.995	0.004
D48.2 Peripheral nerves and autonomic nervous system	0.004	0.995	0.000
S06.7 Intracranial injury with prolonged coma	0.000	0.996	0.004
D48.7 Other specified sites	0.004	0.996	0.000
O26.2 Pregnancy care of habitual aborter	0.004	0.996	0.000
S06.5 Traumatic subdural haemorrhage	0.000	0.996	0.004
S06.41 Epidural haemorrhage (with open intracranial wound)	0.000	0.996	0.004
S06.1 Traumatic cerebral oedema	0.000	0.996	0.004
M89.92 Disorder of bone, unspecified (Upper arm)	0.004	0.996	0.000
D48.9 Neoplasms of uncertain or unknown behaviour, unspecified	0.004	0.996	0.000
D48.1 Connective and other soft tissue	0.004	0.996	0.000
O26.3 Retained intra-uterine contraceptive device in pregnancy	0.004	0.996	0.000
C63.9 Male genital organ, unspecified	0.004	0.996	0.000
C63.8 Overlapping lesion of male genital organs	0.004	0.996	0.000
C63.7 Other specified male genital organs	0.004	0.996	0.000
C63.1 Spermatic cord	0.004	0.996	0.000
C63.0 Epididymis	0.004	0.996	0.000
M89.8 Other specified disorders of bone	0.004	0.996	0.000
M89.95 Disorder of bone, unspecified (Pelvic region and thigh)	0.004	0.996	0.000
K75.8 Other specified inflammatory liver diseases	0.000	0.996	0.004
O26.6 Liver disorders in pregnancy, childbirth and the puerperium	0.004	0.996	0.000
S06.30 Focal brain injury (without open intracranial wound)	0.000	0.996	0.004
M89.88 Other specified disorders of bone (Other)	0.004	0.996	0.000
S06.81 Other intracranial injuries (with open intracranial wound)	0.000	0.996	0.004
O26.5 Maternal hypotension syndrome	0.004	0.996	0.000
O26.4 Herpes gestationis	0.004	0.996	0.000
O26.1 Low weight gain in pregnancy	0.004	0.996	0.000
S06.9 Intracranial injury, unspecified	0.000	0.996	0.004
M89 Other disorders of bone	0.004	0.996	0.000
H62.8 Other disorders of external ear in diseases classified elsewhere	0.004	0.996	0.000
H62.4 Otitis externa in other diseases classified elsewhere	0.004	0.996	0.000
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere	0.004	0.996	0.000
H62.2 Otitis externa in mycoses	0.004	0.996	0.000
H62.1 Otitis externa in viral diseases classified elsewhere	0.004	0.996	0.000
C62 Malignant neoplasm of testis	0.004	0.996	0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)	0.004	0.996	0.000
D03.6 Melanoma in situ of upper limb, including shoulder	0.004	0.996	0.000
H62.0 Otitis externa in bacterial diseases classified elsewhere	0.004	0.996	0.000
H61.1 Non-infective disorders of pinna	0.004	0.996	0.000
M89.99 Disorder of bone, unspecified (Site unspecified)	0.004	0.996	0.000
M89.93 Disorder of bone, unspecified (Forearm)	0.004	0.996	0.000
M89.91 Disorder of bone, unspecified (Shoulder region)	0.004	0.996	0.000
M89.90 Disorder of bone, unspecified (Multiple sites)	0.004	0.996	0.000
O26.0 Excessive weight gain in pregnancy	0.004	0.996	0.000
M89.96 Disorder of bone, unspecified (Lower leg)	0.004	0.996	0.000
S06.31 Focal brain injury (with open intracranial wound)	0.000	0.996	0.004
C60.8 Overlapping lesion of penis	0.004	0.996	0.000
C60.2 Body of penis	0.004	0.996	0.000
C60.1 Glans penis	0.004	0.996	0.000
C60.0 Prepuce	0.004	0.996	0.000
H61 Other disorders of external ear	0.004	0.996	0.000
S82.8 Fractures of other parts of lower leg	0.004	0.996	0.000
C60.9 Penis, unspecified	0.003	0.996	0.000
M89.89 Other specified disorders of bone (Site unspecified)	0.004	0.996	0.000
M89.86 Other specified disorders of bone (Lower leg)	0.004	0.996	0.000
D03.5 Melanoma in situ of trunk	0.004	0.996	0.000
M89.98 Disorder of bone, unspecified (Other)	0.003	0.996	0.000
M89.87 Other specified disorders of bone (Ankle and foot)	0.003	0.996	0.000
J84.1 Other interstitial pulmonary diseases with fibrosis	0.004	0.996	0.000
M89.0 Algoneurodystrophy	0.003	0.996	0.000
S06.71 Intracranial injury with prolonged coma (with open intracranial wound)	0.000	0.997	0.003
S06.70 Intracranial injury with prolonged coma (without open intracranial wound)	0.000	0.997	0.003
S06.0 Concussion	0.001	0.997	0.003
M88.9 Paget's disease of bone, unspecified	0.000	0.997	0.003
S06.51 Traumatic subdural haemorrhage (with open intracranial wound)	0.000	0.997	0.003
C62.1 Descended testis	0.003	0.997	0.000
M89.06 Algoneurodystrophy (Lower leg)	0.003	0.997	0.000
S06.11 Traumatic cerebral oedema (with open intracranial wound)	0.000	0.997	0.003
M89.85 Other specified disorders of bone (Pelvic region and thigh)	0.003	0.997	0.000
M89.83 Other specified disorders of bone (Forearm)	0.003	0.997	0.000
M89.82 Other specified disorders of bone (Upper arm)	0.003	0.997	0.000
M89.80 Other specified disorders of bone (Multiple sites)	0.003	0.997	0.000
H61.9 Disorder of external ear, unspecified	0.003	0.997	0.000
S06.10 Traumatic cerebral oedema (without open intracranial wound)	0.000	0.997	0.003
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)	0.000	0.997	0.003
M89.4 Other hypertrophic osteo-arthropathy	0.003	0.997	0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere	0.000	0.997	0.003
S06.91 Intracranial injury, unspecified (with open intracranial wound)	0.000	0.997	0.003
M41.90 Scoliosis, unspecified (Multiple sites in spine)	0.003	0.997	0.000
M89.6 Osteopathy after poliomyelitis	0.003	0.997	0.000
M89.2 Other disorders of bone development and growth	0.003	0.997	0.000
M89.1 Epiphyseal arrest	0.003	0.997	0.000
M89.84 Other specified disorders of bone (Hand)	0.003	0.997	0.000
C62.0 Undescended testis	0.003	0.997	0.000
M89.03 Algoneurodystrophy (Forearm)	0.003	0.997	0.000
K50-K52 Noninfective enteritis and colitis	0.003	0.997	0.000
M41.94 Scoliosis, unspecified (Thoracic region)	0.003	0.997	0.000
M89.81 Other specified disorders of bone (Shoulder region)	0.003	0.997	0.000
M41.9 Scoliosis, unspecified	0.003	0.997	0.000
S82.86 Maisonneuve's fracture	0.003	0.997	0.000
S82.81 Fractures of other parts of lower leg (open)	0.003	0.997	0.000
R23.1 Pallor	0.000	0.997	0.003
H33.2 Serous retinal detachment	0.000	0.997	0.003
R23.8 Other and unspecified skin changes	0.000	0.997	0.003
M89.04 Algoneurodystrophy (Hand)	0.003	0.997	0.000
E07.9 Disorder of thyroid, unspecified	0.000	0.997	0.003
M89.3 Hypertrophy of bone	0.003	0.997	0.000
M88.99 Paget's disease of bone, unspecified (Site unspecified)	0.000	0.997	0.003
R23 Other skin changes	0.000	0.997	0.003
M89.08 Algoneurodystrophy (Other)	0.003	0.997	0.000
M89.05 Algoneurodystrophy (Pelvic region and thigh)	0.003	0.997	0.000
M89.02 Algoneurodystrophy (Upper arm)	0.003	0.997	0.000
M89.01 Algoneurodystrophy (Shoulder region)	0.003	0.997	0.000
M89.00 Algoneurodystrophy (Multiple sites)	0.003	0.997	0.000
S06.01 Concussion (with open intracranial wound)	0.001	0.997	0.002
D03 Melanoma in situ	0.003	0.997	0.000
M41.97 Scoliosis, unspecified (Lumbosacral region)	0.003	0.997	0.000
M88.98 Paget's disease of bone, unspecified (Other)	0.000	0.997	0.002
M88.97 Paget's disease of bone, unspecified (Ankle and foot)	0.000	0.997	0.002
M88.96 Paget's disease of bone, unspecified (Lower leg)	0.000	0.997	0.002
M88.94 Paget's disease of bone, unspecified (Hand)	0.000	0.997	0.002
M88.93 Paget's disease of bone, unspecified (Forearm)	0.000	0.997	0.002
M88.92 Paget's disease of bone, unspecified (Upper arm)	0.000	0.997	0.002
M88.91 Paget's disease of bone, unspecified (Shoulder region)	0.000	0.997	0.002
M89.5 Osteolysis	0.003	0.997	0.000
E10.9 Without complications	0.003	0.997	0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)	0.003	0.997	0.000
S06.90 Intracranial injury, unspecified (without open intracranial wound)	0.000	0.997	0.002
S42.30 Fracture of shaft of humerus (closed)	0.003	0.997	0.000
C44.4 Skin of scalp and neck	0.003	0.997	0.000
H61.3 Acquired stenosis of external ear canal	0.002	0.997	0.000
M89.40 Other hypertrophic osteoarthropathy (Multiple sites)	0.002	0.997	0.000
C43.5 Malignant melanoma of trunk	0.003	0.997	0.000
H80-H83 Diseases of inner ear	0.003	0.997	0.000
M88.95 Paget's disease of bone, unspecified (Pelvic region and thigh)	0.000	0.997	0.002
M89.49 Other hypertrophic osteoarthropathy (Site unspecified)	0.002	0.997	0.000
M89.48 Other hypertrophic osteoarthropathy (Other)	0.002	0.997	0.000
M89.47 Other hypertrophic osteoarthropathy (Ankle and foot)	0.002	0.997	0.000
M89.46 Other hypertrophic osteoarthropathy (Lower leg)	0.002	0.997	0.000
M89.45 Other hypertrophic osteoarthropathy (Pelvic region and thigh)	0.002	0.997	0.000
M89.44 Other hypertrophic osteoarthropathy (Hand)	0.002	0.997	0.000
M89.43 Other hypertrophic osteoarthropathy (Forearm)	0.002	0.997	0.000
M89.42 Other hypertrophic osteoarthropathy (Upper arm)	0.002	0.997	0.000
M89.41 Other hypertrophic osteoarthropathy (Shoulder region)	0.002	0.997	0.000
R23.4 Changes in skin texture	0.000	0.997	0.003
M89.19 Epiphyseal arrest (Site unspecified)	0.002	0.997	0.000
M89.18 Epiphyseal arrest (Other)	0.002	0.997	0.000
M89.17 Epiphyseal arrest (Ankle and foot)	0.002	0.997	0.000
M89.16 Epiphyseal arrest (Lower leg)	0.002	0.997	0.000
M89.15 Epiphyseal arrest (Pelvic region and thigh)	0.002	0.997	0.000
M89.14 Epiphyseal arrest (Hand)	0.002	0.997	0.000
M89.13 Epiphyseal arrest (Forearm)	0.002	0.997	0.000
M89.12 Epiphyseal arrest (Upper arm)	0.002	0.997	0.000
M89.11 Epiphyseal arrest (Shoulder region)	0.002	0.997	0.000
M89.10 Epiphyseal arrest (Multiple sites)	0.002	0.997	0.000
M89.29 Other disorders of bone development and growth (Site unspecified)	0.002	0.997	0.000
M89.28 Other disorders of bone development and growth (Other)	0.002	0.997	0.000
M89.27 Other disorders of bone development and growth (Ankle and foot)	0.002	0.997	0.000
M89.26 Other disorders of bone development and growth (Lower leg)	0.002	0.997	0.000
M89.25 Other disorders of bone development and growth (Pelvic region and thigh)	0.002	0.997	0.000
M89.24 Other disorders of bone development and growth (Hand)	0.002	0.997	0.000
M89.23 Other disorders of bone development and growth (Forearm)	0.002	0.997	0.000
M89.22 Other disorders of bone development and growth (Upper arm)	0.002	0.997	0.000
M89.21 Other disorders of bone development and growth (Shoulder region)	0.002	0.997	0.000
M89.20 Other disorders of bone development and growth (Multiple sites)	0.002	0.997	0.000
M89.69 Osteopathy after poliomyelitis (Site unspecified)	0.002	0.997	0.000
M89.68 Osteopathy after poliomyelitis (Other)	0.002	0.997	0.000
M89.67 Osteopathy after poliomyelitis (Ankle and foot)	0.002	0.997	0.000
M89.66 Osteopathy after poliomyelitis (Lower leg)	0.002	0.997	0.000
M89.65 Osteopathy after poliomyelitis (Pelvic region and thigh)	0.002	0.997	0.000
M89.64 Osteopathy after poliomyelitis (Hand)	0.002	0.997	0.000
M89.63 Osteopathy after poliomyelitis (Forearm)	0.002	0.997	0.000
M89.62 Osteopathy after poliomyelitis (Upper arm)	0.002	0.997	0.000
M89.61 Osteopathy after poliomyelitis (Shoulder region)	0.002	0.997	0.000
M89.60 Osteopathy after poliomyelitis (Multiple sites)	0.002	0.997	0.000
H06.3 Other disorders of orbit in diseases classified elsewhere	0.000	0.997	0.002
H06.1 Parasitic infestation of orbit in diseases classified elsewhere	0.000	0.997	0.002
H06.0 Disorders of lachrymal system in diseases classified elsewhere	0.000	0.997	0.002
R23.2 Flushing	0.000	0.997	0.003
H61.8 Other specified disorders of external ear	0.002	0.997	0.000
H60.9 Otitis externa, unspecified	0.002	0.997	0.000
K51.3 Ulcerative (chronic) rectosigmoiditis	0.003	0.997	0.000
R23.0 Cyanosis	0.000	0.997	0.002
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.002	0.998	0.000
M89.09 Algoneurodystrophy (Site unspecified)	0.002	0.998	0.000
L02.0 Cutaneous abscess, furuncle and carbuncle of face	0.002	0.998	0.000
M66.24 Spontaneous rupture of extensor tendons (Hand)	0.002	0.998	0.000
K75 Other inflammatory liver diseases	0.000	0.998	0.002
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)	0.002	0.998	0.000
M41.93 Scoliosis, unspecified (Cervicothoracic region)	0.002	0.998	0.000
M41.92 Scoliosis, unspecified (Cervical region)	0.002	0.998	0.000
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)	0.002	0.998	0.000
M89.07 Algoneurodystrophy (Ankle and foot)	0.002	0.998	0.000
K75.9 Inflammatory liver disease, unspecified	0.000	0.998	0.002
T02.40 Fractures involving multiple regions of both upper limbs (closed)	0.002	0.998	0.000
K75.4 Autoimmune hepatitis	0.000	0.998	0.002
R23.3 Spontaneous ecchymoses	0.000	0.998	0.002
S62.80 Fracture of other and unspecified parts of wrist and hand (closed)	0.002	0.998	0.000
M89.39 Hypertrophy of bone (Site unspecified)	0.002	0.998	0.000
M89.38 Hypertrophy of bone (Other)	0.002	0.998	0.000
M89.36 Hypertrophy of bone (Lower leg)	0.002	0.998	0.000
M89.35 Hypertrophy of bone (Pelvic region and thigh)	0.002	0.998	0.000
M89.34 Hypertrophy of bone (Hand)	0.002	0.998	0.000
M89.33 Hypertrophy of bone (Forearm)	0.002	0.998	0.000
M89.32 Hypertrophy of bone (Upper arm)	0.002	0.998	0.000
M89.31 Hypertrophy of bone (Shoulder region)	0.002	0.998	0.000
M89.30 Hypertrophy of bone (Multiple sites)	0.002	0.998	0.000
J35.8 Other chronic diseases of tonsils and adenoids	0.002	0.998	0.000
M67.8 Other specified disorders of synovium and tendon	0.002	0.998	0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness	0.002	0.998	0.000
M88 Paget's disease of bone [osteitis deformans]	0.001	0.998	0.001
D03.7 Melanoma in situ of lower limb, including hip	0.002	0.998	0.000
D03.4 Melanoma in situ of scalp and neck	0.002	0.998	0.000
L30.9 Dermatitis, unspecified	0.000	0.998	0.002
D03.2 Melanoma in situ of ear and external auricular canal	0.002	0.998	0.000
M89.59 Osteolysis (Site unspecified)	0.002	0.998	0.000
M89.58 Osteolysis (Other)	0.002	0.998	0.000
M89.57 Osteolysis (Ankle and foot)	0.002	0.998	0.000
M89.56 Osteolysis (Lower leg)	0.002	0.998	0.000
M89.54 Osteolysis (Hand)	0.002	0.998	0.000
M89.53 Osteolysis (Forearm)	0.002	0.998	0.000
M89.52 Osteolysis (Upper arm)	0.002	0.998	0.000
M89.51 Osteolysis (Shoulder region)	0.002	0.998	0.000
M89.50 Osteolysis (Multiple sites)	0.002	0.998	0.000
D03.9 Melanoma in situ, unspecified	0.002	0.998	0.000
D03.8 Melanoma in situ of other sites	0.002	0.998	0.000
D03.1 Melanoma in situ of eyelid, including canthus	0.002	0.998	0.000
D03.0 Melanoma in situ of lip	0.002	0.998	0.000
N02.9 Unspecified	0.000	0.998	0.002
U89.8 Agent resistant to other single specified antibiotic	0.002	0.998	0.000
M41.96 Scoliosis, unspecified (Lumbar region)	0.002	0.998	0.000
L57.0 Actinic keratosis	0.002	0.998	0.000
H82 Vertiginous syndromes in diseases classified elsewhere	0.002	0.998	0.000
N75.0 Cyst of Bartholin's gland	0.002	0.998	0.000
K08.2 Atrophy of edentulous alveolar ridge	0.002	0.998	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.002	0.998	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.002	0.998	0.000
W11.6 Industrial and construction area	0.002	0.998	0.000
W07.9 Unspecified place	0.002	0.998	0.000
Z97.5 Presence of (intra-uterine) contraceptive device	0.000	0.998	0.002
N05.1 Focal and segmental glomerular lesions	0.000	0.998	0.002
L02 Cutaneous abscess, furuncle and carbuncle	0.002	0.998	0.000
M41.99 Scoliosis, unspecified (Site unspecified)	0.002	0.998	0.000
M89.37 Hypertrophy of bone (Ankle and foot)	0.002	0.998	0.000
K75.2 Nonspecific reactive hepatitis	0.000	0.998	0.002
K75.1 Phlebitis of portal vein	0.000	0.998	0.002
N76.4 Abscess of vulva	0.002	0.998	0.000
Q21 Congenital malformations of cardiac septa	0.000	0.998	0.002
H61.0 Perichondritis of external ear	0.002	0.998	0.000
H57.9 Disorder of eye and adnexa, unspecified	0.002	0.998	0.000
M88.8 Paget's disease of other bones	0.001	0.998	0.001
M88.0 Paget's disease of skull	0.001	0.998	0.001
N03.9 Unspecified	0.000	0.998	0.002
S06.00 Concussion (without open intracranial wound)	0.001	0.998	0.001
D37.4 Colon	0.002	0.998	0.000
M66.2 Spontaneous rupture of extensor tendons	0.002	0.998	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.002	0.998	0.000
E61.1 Iron deficiency	0.002	0.998	0.000
T50.8 Diagnostic agents	0.002	0.998	0.000
O16 Unspecified maternal hypertension	0.000	0.998	0.002
B44.9 Aspergillosis, unspecified	0.000	0.998	0.002
T46.4 Angiotensin-converting-enzyme inhibitors	0.002	0.998	0.000
Y04.8 Other specified place	0.000	0.998	0.002
I77.9 Disorder of arteries and arterioles, unspecified	0.000	0.998	0.002
K51.0 Ulcerative (chronic) enterocolitis	0.002	0.998	0.000
M18.1 Other primary arthrosis of first carpometacarpal joint	0.002	0.998	0.000
K51 Ulcerative colitis	0.002	0.998	0.000
N05 Unspecified nephritic syndrome	0.000	0.998	0.002
O36.4 Maternal care for intra-uterine death	0.000	0.998	0.002
T46.5 Other antihypertensive drugs, not elsewhere classified	0.002	0.998	0.000
M41 Scoliosis	0.002	0.998	0.000
M89.55 Osteolysis (Pelvic region and thigh)	0.001	0.998	0.000
H54.0 Blindness, both eyes	0.002	0.998	0.000
N05.9 Unspecified	0.000	0.998	0.002
N05.8 Other	0.000	0.998	0.002
V48.4 Person injured while boarding or alighting	0.002	0.998	0.000
H57.8 Other specified disorders of eye and adnexa	0.002	0.998	0.000
O12.1 Gestational proteinuria	0.000	0.998	0.002
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.002	0.998	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.002	0.998	0.000
T46.7 Peripheral vasodilators	0.002	0.998	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.002	0.998	0.000
S01.4 Open wound of cheek and temporomandibular area	0.000	0.998	0.002
Z63.0 Problems in relationship with spouse or partner	0.002	0.998	0.000
N70.1 Chronic salpingitis and oophoritis	0.002	0.998	0.000
R26.8 Other and unspecified abnormalities of gait and mobility	0.002	0.998	0.000
M86-M90 Other osteopathies	0.002	0.998	0.000
G93.4 Encephalopathy, unspecified	0.000	0.998	0.002
K08.9 Disorder of teeth and supporting structures, unspecified	0.002	0.998	0.000
L02.9 Cutaneous abscess, furuncle and carbuncle, unspecified	0.002	0.998	0.000
T50.4 Drugs affecting uric acid metabolism	0.002	0.998	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.002	0.998	0.000
N03 Chronic nephritic syndrome	0.000	0.998	0.002
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.002	0.998	0.000
L02.1 Cutaneous abscess, furuncle and carbuncle of neck	0.002	0.998	0.000
S56.5 Injury of other extensor muscle and tendon at forearm level	0.002	0.998	0.000
T02.4 Fractures involving multiple regions of both upper limbs	0.002	0.998	0.000
Z98.1 Arthrodesis status	0.000	0.998	0.002
M66.23 Spontaneous rupture of extensor tendons (Forearm)	0.002	0.998	0.000
M90.10 Periostitis in other infectious diseases classified elsewhere (Multiple sites)	0.002	0.998	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.002	0.998	0.000
W14.9 Unspecified place	0.002	0.998	0.000
N02 Recurrent and persistent haematuria	0.000	0.998	0.002
C92.0 Acute myeloid leukaemia	0.000	0.998	0.002
M41.8 Other forms of scoliosis	0.002	0.998	0.000
Q21.9 Congenital malformation of cardiac septum, unspecified	0.000	0.998	0.001
Q21.8 Other congenital malformations of cardiac septa	0.000	0.998	0.001
Q21.4 Aortopulmonary septal defect	0.000	0.998	0.001
Q21.2 Atrioventricular septal defect	0.000	0.998	0.001
W11 Fall on and from ladder	0.002	0.998	0.000
E61.2 Magnesium deficiency	0.002	0.998	0.000
K75.3 Granulomatous hepatitis, not elsewhere classified	0.000	0.998	0.001
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.002	0.998	0.000
W07 Fall involving chair	0.002	0.998	0.000
M88.09 Paget's disease of skull-Site unspec	0.001	0.998	0.001
M88.08 Paget's disease of skull-Other	0.001	0.998	0.001
M88.07 Paget's disease of skull-Ankle/Foot	0.001	0.998	0.001
M88.06 Paget's disease of skull-Lower Leg	0.001	0.998	0.001
M88.05 Paget's disease of skull-Pelvic/Thigh	0.001	0.998	0.001
M88.04 Paget's disease of skull-Hand	0.001	0.998	0.001
M88.03 Paget's disease of skull-Forearm	0.001	0.998	0.001
M88.02 Paget's disease of skull-Upper arm	0.001	0.998	0.001
M88.01 Paget's disease of skull-Shldr region	0.001	0.998	0.001
M88.00 Paget's disease of skull-Mult sites	0.001	0.998	0.001
M88.89 Paget's disease of other bones (Site unspecified)	0.001	0.998	0.001
M88.88 Paget's disease of other bones (Other)	0.001	0.998	0.001
M88.87 Paget's disease of other bones (Ankle and foot)	0.001	0.998	0.001
M88.86 Paget's disease of other bones (Lower leg)	0.001	0.998	0.001
M88.85 Paget's disease of other bones (Pelvic region and thigh)	0.001	0.998	0.001
M88.84 Paget's disease of other bones (Hand)	0.001	0.998	0.001
M88.83 Paget's disease of other bones (Forearm)	0.001	0.998	0.001
M88.82 Paget's disease of other bones (Upper arm)	0.001	0.998	0.001
M88.81 Paget's disease of other bones (Shoulder region)	0.001	0.998	0.001
M88.80 Paget's disease of other bones (Multiple sites)	0.001	0.998	0.001
F60.3 Emotionally unstable personality disorder	0.002	0.998	0.000
H57.0 Anomalies of pupillary function	0.002	0.998	0.000
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites	0.002	0.998	0.000
M90.1 Periostitis in other infectious diseases classified elsewhere	0.002	0.998	0.000
S56.3 Injury of extensor or abductor muscles and tendons of thumb at forearm level	0.002	0.998	0.000
J84 Other interstitial pulmonary diseases	0.002	0.998	0.000
J84.8 Other specified interstitial pulmonary diseases	0.002	0.998	0.000
L89.1 Stage II decubitus ulcer	0.002	0.998	0.000
M90 Osteopathies in diseases classified elsewhere	0.002	0.998	0.000
M66.29 Spontaneous rupture of extensor tendons (Site unspecified)	0.001	0.998	0.000
M66.28 Spontaneous rupture of extensor tendons-Other	0.001	0.998	0.000
M66.27 Spontaneous rupture of extensor tendons (Ankle and foot)	0.001	0.998	0.000
M66.26 Spontaneous rupture of extensor tendons (Lower leg)	0.001	0.998	0.000
M66.25 Spontaneous rupture of extensor tendons (Pelvic region and thigh)	0.001	0.998	0.000
M66.22 Spontaneous rupture of extensor tendons (Upper arm)	0.001	0.998	0.000
M66.21 Spontaneous rupture of extensor tendons (Shoulder region)	0.001	0.998	0.000
M66.20 Spontaneous rupture of extensor tendons (Multiple sites)	0.001	0.998	0.000
Z29.1 Prophylactic immunotherapy	0.000	0.998	0.002
Q21.0 Ventricular septal defect	0.000	0.998	0.001
H57 Other disorders of eye and adnexa	0.002	0.998	0.000
S82.30 Fracture of lower end of tibia (closed)	0.000	0.998	0.002
N05.7 Diffuse crescentic glomerulonephritis	0.000	0.998	0.001
N05.6 Dense deposit disease	0.000	0.998	0.001
N05.4 Diffuse endocapillary proliferative glomerulonephritis	0.000	0.998	0.001
N05.3 Diffuse mesangial proliferative glomerulonephritis	0.000	0.998	0.001
N05.0 Minor glomerular abnormality	0.000	0.998	0.001
N08.5 Glomerular disorders in systemic connective tissue disorders	0.000	0.998	0.002
N08 Glomerular disorders in diseases classified elsewhere	0.000	0.998	0.002
U89 Agent resistant to other and unspecified antibiotics	0.002	0.998	0.000
N00-N08 Glomerular diseases	0.000	0.998	0.002
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.000	0.998	0.002
H18.4 Corneal degeneration	0.002	0.998	0.000
K51.1 Ulcerative (chronic) ileocolitis	0.001	0.998	0.000
M41.5 Other secondary scoliosis	0.001	0.998	0.000
M41.4 Neuromuscular scoliosis	0.001	0.998	0.000
M41.3 Thoracogenic scoliosis	0.001	0.998	0.000
M41.2 Other idiopathic scoliosis	0.001	0.998	0.000
M41.1 Juvenile idiopathic scoliosis	0.001	0.998	0.000
M41.0 Infantile idiopathic scoliosis	0.001	0.998	0.000
O10.0 Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium	0.000	0.998	0.002
M41.80 Other forms of scoliosis (Multiple sites in spine)	0.001	0.998	0.000
M48.54 Collapsed vertebra, not elsewhere classified (Thoracic region)	0.002	0.998	0.000
W11.5 Trade and service area	0.001	0.998	0.000
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.000	0.998	0.002
M92.7 Juvenile osteochondrosis of metatarsus	0.001	0.998	0.000
R26.2 Difficulty in walking, not elsewhere classified	0.002	0.998	0.000
C43.9 Malignant melanoma of skin, unspecified	0.002	0.998	0.000
I70.2 Atherosclerosis of arteries of the extremities	0.001	0.998	0.000
K75.0 Abscess of liver	0.000	0.998	0.001
M87.2 Osteonecrosis due to previous trauma	0.001	0.998	0.000
V89.2 Person injured in unspecified motor-vehicle accident, traffic	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations