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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1237485
log Bayes Factor = 54.0728
Chromosome 6   position 28,894,344  (GRCh37) Explore rs1237485 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E05.9 Thyrotoxicosis, unspecified
0.000 0.001 0.999
E10.9 Without complications
0.000 0.002 0.998
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.003 0.997
E10-E14 Diabetes mellitus
0.000 0.003 0.997
E16 Other disorders of pancreatic internal secretion
0.000 0.003 0.997
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.004 0.996
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.005 0.995
E00-E07 Disorders of thyroid gland
0.000 0.007 0.993
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.047 0.953
E10.2 With renal complications
0.000 0.055 0.945
E10.1 With ketoacidosis
0.000 0.071 0.929
E10.4 With neurological complications
0.000 0.084 0.916
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.828 0.172 0.000
E05.8 Other thyrotoxicosis
0.000 0.185 0.815
E13 Other specified diabetes mellitus
0.000 0.205 0.795
E16.1 Other hypoglycaemia
0.000 0.220 0.780
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.233 0.767
E10.7 With multiple complications
0.000 0.250 0.750
E05.5 Thyroid crisis or storm
0.000 0.285 0.715
E05.4 Thyrotoxicosis factitia
0.000 0.285 0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.285 0.715
E12 Malnutrition-related diabetes mellitus
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
E15 Nondiabetic hypoglycaemic coma
0.000 0.286 0.714
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.288 0.712
E00 Congenital iodine-deficiency syndrome
0.000 0.288 0.712
E10.0 With coma
0.000 0.305 0.695
E10.5 With peripheral circulatory complications
0.000 0.319 0.681
E40-E46 Malnutrition
0.000 0.322 0.678
E10.6 With other specified complications
0.000 0.330 0.670
E14 Unspecified diabetes mellitus
0.000 0.341 0.659
E13.9 Without complications
0.000 0.353 0.647
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.363 0.637
E07 Other disorders of thyroid
0.000 0.400 0.600
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.425 0.575
E13.3 With ophthalmic complications
0.000 0.425 0.575
E13.8 With unspecified complications
0.000 0.430 0.570
E13.7 With multiple complications
0.000 0.430 0.570
E13.6 With other specified complications
0.000 0.430 0.570
E13.5 With peripheral circulatory complications
0.000 0.430 0.570
E13.4 With neurological complications
0.000 0.430 0.570
E13.2 With renal complications
0.000 0.430 0.570
E13.1 With ketoacidosis
0.000 0.430 0.570
E13.0 With coma
0.000 0.430 0.570
E06 Thyroiditis
0.000 0.433 0.567
E14.3 With ophthalmic complications
0.000 0.459 0.541
E14.1 With ketoacidosis
0.000 0.468 0.532
E12.9 Without complications
0.000 0.487 0.512
E12.8 With unspecified complications
0.000 0.487 0.512
E12.7 With multiple complications
0.000 0.487 0.512
E12.6 With other specified complications
0.000 0.487 0.512
E12.5 With peripheral circulatory complications
0.000 0.487 0.512
E12.4 With neurological complications
0.000 0.487 0.512
E12.3 With ophthalmic complications
0.000 0.487 0.512
E12.2 With renal complications
0.000 0.487 0.512
E12.1 With ketoacidosis
0.000 0.487 0.512
E12.0 With coma
0.000 0.487 0.512
E10.8 With unspecified complications
0.000 0.489 0.510
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.489 0.511
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.489 0.511
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.489 0.511
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.489 0.511
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.489 0.511
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.489 0.511
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.489 0.511
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.489 0.511
E14.6 With other specified complications
0.000 0.498 0.501
E14.4 With neurological complications
0.000 0.509 0.491
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.514 0.486
E45 Retarded development following protein-energy malnutrition
0.000 0.514 0.486
E43 Unspecified severe protein-energy malnutrition
0.000 0.514 0.486
E42 Marasmic kwashiorkor
0.000 0.514 0.486
E41 Nutritional marasmus
0.000 0.514 0.486
E40 Kwashiorkor
0.000 0.514 0.486
E14.8 With unspecified complications
0.000 0.520 0.480
E07.8 Other specified disorders of thyroid
0.000 0.524 0.476
E14.7 With multiple complications
0.000 0.528 0.472
E06.9 Thyroiditis, unspecified
0.000 0.540 0.460
E14.2 Withrenal complications
0.000 0.548 0.452
E46 Unspecified protein-energy malnutrition
0.000 0.550 0.450
E14.5 With peripheral circulatory complications
0.000 0.553 0.446
E14.0 With coma
0.000 0.557 0.442
E07.1 Dyshormogenetic goitre
0.000 0.570 0.430
E07.0 Hypersecretion of calcitonin
0.000 0.570 0.430
K90 Intestinal malabsorption
0.000 0.571 0.428
E06.1 Subacute thyroiditis
0.000 0.589 0.410
E03 Other hypothyroidism
0.000 0.591 0.409
E06.4 Drug-induced thyroiditis
0.000 0.593 0.406
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.593 0.406
E06.0 Acute thyroiditis
0.000 0.593 0.406
E11 Non-insulin-dependent diabetes mellitus
0.000 0.598 0.402
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.608 0.391
E06.5 Other chronic thyroiditis
0.000 0.609 0.390
E11.6 With other specified complications
0.000 0.633 0.367
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.634 0.366
E44.1 Mild protein-energy malnutrition
0.000 0.651 0.349
E44.0 Moderate protein-energy malnutrition
0.000 0.651 0.349
E11.1 With ketoacidosis
0.000 0.653 0.347
E11.0 With coma
0.000 0.666 0.334
E65-E68 Obesity and other hyperalimentation
0.000 0.673 0.327
E11.2 With renal complications
0.000 0.677 0.323
E50-E64 Other nutritional deficiencies
0.000 0.687 0.312
K90.3 Pancreatic steatorrhoea
0.000 0.693 0.307
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.693 0.307
K90.1 Tropical sprue
0.000 0.693 0.307
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.694 0.306
K90.8 Other intestinal malabsorption
0.000 0.706 0.294
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.706 0.294
E03.5 Myxoedema coma
0.000 0.707 0.293
E03.4 Atrophy of thyroid (acquired)
0.000 0.707 0.293
E03.3 Postinfectious hypothyroidism
0.000 0.707 0.293
E11.7 With multiple complications
0.000 0.711 0.288
E03.1 Congenital hypothyroidism without goitre
0.000 0.718 0.282
E03.8 Other specified hypothyroidism
0.000 0.761 0.239
E11.8 With unspecified complications
0.000 0.761 0.239
E67 Other hyperalimentation
0.000 0.766 0.234
E68 Sequelae of hyperalimentation
0.000 0.766 0.234
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.768 0.232
E54 Ascorbic acid deficiency
0.000 0.772 0.228
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.776 0.224
E63 Other nutritional deficiencies
0.000 0.776 0.224
E50 Vitamin A deficiency
0.000 0.776 0.224
E60 Dietary zinc deficiency
0.000 0.776 0.224
E59 Dietary selenium deficiency
0.000 0.776 0.224
E52 Niacin deficiency [pellagra]
0.000 0.776 0.224
E51 Thiamine deficiency
0.000 0.777 0.223
K90.9 Intestinal malabsorption, unspecified
0.000 0.786 0.214
E07.9 Disorder of thyroid, unspecified
0.000 0.787 0.213
E83 Disorders of mineral metabolism
0.163 0.787 0.050
E56 Other vitamin deficiencies
0.000 0.788 0.212
E55 Vitamin D deficiency
0.000 0.793 0.207
E11.5 With peripheral circulatory complications
0.000 0.801 0.199
E58 Dietary calcium deficiency
0.000 0.805 0.195
I83 Varicose veins of lower extremities
0.186 0.814 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.821 0.179
E65 Localised adiposity
0.000 0.823 0.177
E70-E90 Metabolic disorders
0.001 0.829 0.169
E67.8 Other specified hyperalimentation
0.000 0.832 0.168
E67.3 Hypervitaminosis D
0.000 0.832 0.168
E67.2 Megavitamin-B6 syndrome
0.000 0.832 0.168
E67.1 Hypercarotenaemia
0.000 0.832 0.168
E67.0 Hypervitaminosis A
0.000 0.832 0.168
M45.X9 Ankylosing spondylitis (Site unspecified)
0.167 0.833 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.836 0.164
E24 Cushing's syndrome
0.000 0.837 0.163
E61 Deficiency of other nutrient elements
0.000 0.839 0.161
E50.9 Vitamin A deficiency, unspecified
0.000 0.839 0.161
E50.8 Other manifestations of vitamin A deficiency
0.000 0.839 0.161
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.839 0.161
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.839 0.161
E50.5 Vitamin A deficiency with night blindness
0.000 0.839 0.161
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.839 0.161
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.839 0.161
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.839 0.161
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.839 0.161
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.839 0.161
E63.9 Nutritional deficiency, unspecified
0.000 0.839 0.161
E63.8 Other specified nutritional deficiencies
0.000 0.839 0.161
E63.1 Imbalance of constituents of food intake
0.000 0.839 0.161
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.839 0.161
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.839 0.161
E64.8 Sequelae of other nutritional deficiencies
0.000 0.839 0.161
E64.3 Sequelae of rickets
0.000 0.839 0.161
E64.2 Sequelae of vitamin C deficiency
0.000 0.839 0.161
E64.1 Sequelae of vitamin A deficiency
0.000 0.839 0.161
E64.0 Sequelae of protein-energy malnutrition
0.000 0.839 0.161
E51.9 Thiamine deficiency, unspecified
0.000 0.840 0.160
E51.8 Other manifestations of thiamine deficiency
0.000 0.840 0.160
E51.1 Beriberi
0.000 0.840 0.160
E78.2 Mixed hyperlipidaemia
0.000 0.840 0.160
E51.2 Wernicke's encephalopathy
0.000 0.841 0.159
E83.8 Other disorders of mineral metabolism
0.117 0.847 0.036
E83.2 Disorders of zinc metabolism
0.117 0.847 0.036
E83.0 Disorders of copper metabolism
0.117 0.847 0.036
E56.9 Vitamin deficiency, unspecified
0.000 0.848 0.152
E56.8 Deficiency of other vitamins
0.000 0.848 0.152
E56.0 Deficiency of vitamin E
0.000 0.848 0.152
E83.3 Disorders of phosphorus metabolism
0.139 0.848 0.012
E83.9 Disorder of mineral metabolism, unspecified
0.117 0.848 0.035
E53 Deficiency of other B group vitamins
0.000 0.850 0.150
E55.0 Rickets, active
0.000 0.851 0.149
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.855 0.145
E78.1 Pure hyperglyceridaemia
0.000 0.856 0.144
E78.5 Hyperlipidaemia, unspecified
0.000 0.858 0.142
E06.3 Autoimmune thyroiditis
0.001 0.860 0.139
E24.9 Cushing's syndrome, unspecified
0.000 0.860 0.140
E56.1 Deficiency of vitamin K
0.000 0.860 0.139
E88 Other metabolic disorders
0.000 0.862 0.137
E21.3 Hyperparathyroidism, unspecified
0.000 0.862 0.138
E24.0 Pituitary-dependent Cushing's disease
0.000 0.865 0.135
E20 Hypoparathyroidism
0.000 0.865 0.135
I83.0 Varicose veins of lower extremities with ulcer
0.134 0.866 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.866 0.133
E78.6 Lipoprotein deficiency
0.000 0.868 0.132
E55.9 Vitamin D deficiency, unspecified
0.000 0.868 0.131
E74 Other disorders of carbohydrate metabolism
0.001 0.869 0.130
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.871 0.129
E32 Diseases of thymus
0.000 0.871 0.129
E30 Disorders of puberty, not elsewhere classified
0.000 0.871 0.129
E25 Adrenogenital disorders
0.000 0.872 0.128
E28 Ovarian dysfunction
0.000 0.873 0.127
E31 Polyglandular dysfunction
0.000 0.873 0.126
E14.9 Without complications
0.000 0.875 0.125
E78.3 Hyperchylomicronaemia
0.000 0.876 0.124
E84 Cystic fibrosis
0.001 0.876 0.123
E85 Amyloidosis
0.001 0.877 0.123
E24.2 Drug-induced Cushing's syndrome
0.000 0.877 0.123
E77 Disorders of glycoprotein metabolism
0.001 0.877 0.122
E76 Disorders of glycosaminoglycan metabolism
0.001 0.877 0.122
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.877 0.122
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.877 0.122
E73 Lactose intolerance
0.001 0.878 0.121
I77 Other disorders of arteries and arterioles
0.000 0.879 0.121
I73 Other peripheral vascular diseases
0.000 0.879 0.121
E11.3 With ophthalmic complications
0.000 0.879 0.121
I73.9 Peripheral vascular disease, unspecified
0.000 0.879 0.121
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.120 0.879 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.880 0.120
E88.9 Metabolic disorder, unspecified
0.000 0.881 0.119
C15-C26 Malignant neoplasms of digestive organs
0.000 0.882 0.118
C15 Malignant neoplasm of oesophagus
0.000 0.883 0.117
E24.8 Other Cushing's syndrome
0.000 0.883 0.117
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.883 0.117
E24.3 Ectopic ACTH syndrome
0.000 0.883 0.117
E24.1 Nelson's syndrome
0.000 0.883 0.117
C20 Malignant neoplasm of rectum
0.000 0.883 0.117
E70 Disorders of aromatic amino-acid metabolism
0.001 0.883 0.115
E61.9 Deficiency of nutrient element, unspecified
0.000 0.884 0.115
E61.8 Deficiency of other specified nutrient elements
0.000 0.884 0.115
E61.7 Deficiency of multiple nutrient elements
0.000 0.884 0.115
E61.6 Vanadium deficiency
0.000 0.884 0.115
E61.5 Molybdenum deficiency
0.000 0.884 0.115
E61.4 Chromium deficiency
0.000 0.884 0.115
E61.3 Manganese deficiency
0.000 0.884 0.115
E61.0 Copper deficiency
0.000 0.884 0.115
I74 Arterial embolism and thrombosis
0.000 0.885 0.115
I77.6 Arteritis, unspecified
0.000 0.885 0.115
E79 Disorders of purine and pyrimidine metabolism
0.001 0.885 0.113
I77.9 Disorder of arteries and arterioles, unspecified
0.000 0.886 0.114
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.888 0.112
E72 Other disorders of amino-acid metabolism
0.001 0.888 0.111
E29 Testicular dysfunction
0.000 0.888 0.111
E03.9 Hypothyroidism, unspecified
0.000 0.889 0.111
E53.9 Vitamin B deficiency, unspecified
0.000 0.889 0.110
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.890 0.110
E88.2 Lipomatosis, not elsewhere classified
0.000 0.891 0.108
I74.5 Embolism and thrombosis of iliac artery
0.000 0.892 0.108
I72 Other aneurysm
0.000 0.892 0.108
E53.1 Pyridoxine deficiency
0.000 0.892 0.108
E53.0 Riboflavin deficiency
0.000 0.892 0.108
E75.5 Other lipid storage disorders
0.001 0.894 0.106
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.894 0.105
E34 Other endocrine disorders
0.000 0.895 0.105
E21.2 Other hyperparathyroidism
0.000 0.895 0.105
C15.5 Lower third of oesophagus
0.000 0.895 0.105
E21.4 Other specified disorders of parathyroid gland
0.000 0.895 0.104
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.895 0.104
I73.0 Raynaud's syndrome
0.000 0.897 0.103
C15.4 Middle third of oesophagus
0.000 0.897 0.103
E20.9 Hypoparathyroidism, unspecified
0.000 0.897 0.103
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.898 0.102
I77.8 Other specified disorders of arteries and arterioles
0.000 0.898 0.102
E61.2 Magnesium deficiency
0.000 0.898 0.102
E85.4 Organ-limited amyloidosis
0.000 0.898 0.101
E78.4 Other hyperlipidaemia
0.000 0.899 0.101
C15.9 Oesophagus, unspecified
0.000 0.901 0.099
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.902 0.098
E75.2 Other sphingolipidosis
0.001 0.902 0.097
E20.8 Other hypoparathyroidism
0.000 0.903 0.097
E20.1 Pseudohypoparathyroidism
0.000 0.903 0.097
E20.0 Idiopathic hypoparathyroidism
0.000 0.903 0.097
E75.6 Lipid storage disorder, unspecified
0.001 0.904 0.095
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.904 0.095
E75.3 Sphingolipidosis, unspecified
0.001 0.904 0.095
E75.1 Other gangliosidosis
0.001 0.904 0.095
E75.0 GM2 gangliosidosis
0.001 0.904 0.095
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.904 0.096
E28.2 Polycystic ovarian syndrome
0.000 0.905 0.095
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.906 0.093
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.906 0.093
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.906 0.093
E74.2 Disorders of galactose metabolism
0.001 0.906 0.093
E74.1 Disorders of fructose metabolism
0.001 0.906 0.093
E85.3 Secondary systemic amyloidosis
0.001 0.907 0.092
C25 Malignant neoplasm of pancreas
0.000 0.907 0.093
I70 Atherosclerosis
0.000 0.907 0.093
E30.9 Disorder of puberty, unspecified
0.000 0.907 0.092
E30.8 Other disorders of puberty
0.000 0.907 0.092
E30.1 Precocious puberty
0.000 0.907 0.092
E30.0 Delayed puberty
0.000 0.907 0.092
E32.9 Disease of thymus, unspecified
0.000 0.907 0.092
E32.8 Other diseases of thymus
0.000 0.907 0.092
E32.1 Abscess of thymus
0.000 0.907 0.092
E32.0 Persistent hyperplasia of thymus
0.000 0.907 0.092
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.907 0.092
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.907 0.092
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.907 0.092
E25.9 Adrenogenital disorder, unspecified
0.000 0.908 0.092
E25.8 Other adrenogenital disorders
0.000 0.908 0.092
I77.3 Arterial fibromuscular dysplasia
0.000 0.908 0.092
I72.4 Aneurysm of artery of lower extremity
0.000 0.908 0.092
E28.9 Ovarian dysfunction, unspecified
0.000 0.908 0.091
E28.8 Other ovarian dysfunction
0.000 0.908 0.091
E28.1 Androgen excess
0.000 0.908 0.091
E28.0 Oestrogen excess
0.000 0.908 0.091
E74.0 Glycogen storage disease
0.001 0.908 0.091
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.908 0.091
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.909 0.091
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.909 0.090
E31.9 Polyglandular dysfunction, unspecified
0.000 0.909 0.091
E31.8 Other polyglandular dysfunction
0.000 0.909 0.091
E31.1 Polyglandular hyperfunction
0.000 0.909 0.091
I77.1 Stricture of artery
0.000 0.909 0.091
C15.0 Cervical part of oesophagus
0.000 0.909 0.091
I72.3 Aneurysm of iliac artery
0.000 0.910 0.090
E85.8 Other amyloidosis
0.001 0.911 0.089
I73.8 Other specified peripheral vascular diseases
0.000 0.911 0.089
E84.8 Cystic fibrosis with other manifestations
0.001 0.911 0.088
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.911 0.088
E88.8 Other specified metabolic disorders
0.000 0.911 0.089
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.911 0.088
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.911 0.088
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.911 0.088
E31.0 Autoimmune polyglandular failure
0.000 0.911 0.088
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.911 0.089
E84.9 Cystic fibrosis, unspecified
0.001 0.912 0.088
E71.3 Disorders of fatty-acid metabolism
0.001 0.912 0.087
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.912 0.087
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.912 0.087
E71.0 Maple-syrup-urine disease
0.001 0.912 0.087
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.912 0.087
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.912 0.087
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.912 0.087
E76.2 Other mucopolysaccharidoses
0.001 0.912 0.087
E76.1 Mucopolysaccharidosis, type II
0.001 0.912 0.087
E76.0 Mucopolysaccharidosis, type I
0.001 0.912 0.087
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.912 0.087
E77.8 Other disorders of glycoprotein metabolism
0.001 0.912 0.087
E77.1 Defects in glycoprotein degradation
0.001 0.912 0.087
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.912 0.087
I77.2 Rupture of artery
0.000 0.912 0.088
I72.0 Aneurysm of carotid artery
0.000 0.912 0.088
E73.8 Other lactose intolerance
0.001 0.912 0.087
E73.1 Secondary lactase deficiency
0.001 0.912 0.087
E73.0 Congenital lactase deficiency
0.001 0.912 0.087
I77.5 Necrosis of artery
0.000 0.913 0.087
I77.4 Coeliac artery compression syndrome
0.000 0.913 0.087
E28.3 Primary ovarian failure
0.000 0.913 0.087
E73.9 Lactose intolerance, unspecified
0.001 0.913 0.086
C15.3 Upper third of oesophagus
0.000 0.915 0.085
C15.1 Thoracic part of oesophagus
0.000 0.915 0.085
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.915 0.085
C15.8 Overlapping lesion of oesophagus
0.000 0.916 0.084
C15.2 Abdominal part of oesophagus
0.000 0.916 0.084
I72.1 Aneurysm of artery of upper extremity
0.000 0.916 0.084
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.916 0.083
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.916 0.083
E70.2 Disorders of tyrosine metabolism
0.001 0.916 0.083
E70.1 Other hyperphenylalaninaemias
0.001 0.916 0.083
E70.0 Classical phenylketonuria
0.001 0.916 0.083
C17 Malignant neoplasm of small intestine
0.000 0.916 0.084
E11.4 With neurological complications
0.000 0.917 0.083
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.917 0.083
E26 Hyperaldosteronism
0.001 0.917 0.083
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.918 0.081
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.918 0.081
E79.1 Lesch-Nyhan syndrome
0.001 0.918 0.081
E88.3 Tumour lysis syndrome
0.001 0.918 0.081
E29.9 Testicular dysfunction, unspecified
0.000 0.919 0.081
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.920 0.080
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.920 0.079
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.920 0.079
E72.5 Disorders of glycine metabolism
0.001 0.920 0.079
E72.4 Disorders of ornithine metabolism
0.001 0.920 0.079
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.920 0.079
E72.2 Disorders of urea cycle metabolism
0.001 0.920 0.079
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.920 0.080
E29.8 Other testicular dysfunction
0.000 0.920 0.080
E29.0 Testicular hyperfunction
0.000 0.920 0.080
M45 Ankylosing spondylitis
0.080 0.920 0.000
C17.0 Duodenum
0.000 0.921 0.079
E72.0 Disorders of amino-acid transport
0.001 0.922 0.077
I72.6 Aneurysm and dissection of vertebral artery
0.000 0.922 0.078
I72.5 Aneurysm and dissection of other precerebral arteries
0.000 0.922 0.078
E70.3 Albinism
0.001 0.922 0.077
E61.1 Iron deficiency
0.000 0.923 0.077
C25.3 Pancreatic duct
0.000 0.923 0.077
E34.3 Short stature, not elsewhere classified
0.000 0.923 0.077
I72.9 Aneurysm of unspecified site
0.000 0.923 0.076
E78.8 Other disorders of lipoprotein metabolism
0.000 0.924 0.076
E34.5 Androgen resistance syndrome
0.000 0.924 0.076
E34.4 Constitutional tall stature
0.000 0.924 0.076
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.924 0.076
E34.1 Other hypersecretion of intestinal hormones
0.000 0.924 0.076
E83.4 Disorders of magnesium metabolism
0.053 0.924 0.023
C25.1 Body of pancreas
0.000 0.924 0.076
C21 Malignant neoplasm of anus and anal canal
0.000 0.925 0.075
C25.2 Tail of pancreas
0.000 0.925 0.075
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.926 0.073
I70.2 Atherosclerosis of arteries of the extremities
0.000 0.926 0.074
C25.8 Overlapping lesion of pancreas
0.000 0.927 0.072
E34.9 Endocrine disorder, unspecified
0.000 0.928 0.072
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.928 0.071
C25.4 Endocrine pancreas
0.000 0.928 0.072
I72.2 Aneurysm of renal artery
0.000 0.929 0.071
E22 Hyperfunction of pituitary gland
0.000 0.929 0.071
E34.8 Other specified endocrine disorders
0.000 0.929 0.071
I70.8 Atherosclerosis of other arteries
0.000 0.930 0.070
C24.0 Extrahepatic bile duct
0.000 0.931 0.069
I70.1 Atherosclerosis of renal artery
0.000 0.931 0.069
E21.0 Primary hyperparathyroidism
0.000 0.931 0.069
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.931 0.068
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.000 0.932 0.068
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.933 0.067
E23 Hypofunction and other disorders of pituitary gland
0.000 0.933 0.067
I72.8 Aneurysm of other specified arteries
0.000 0.934 0.066
I79.1 Aortitis in diseases classified elsewhere
0.000 0.934 0.066
I79.0 Aneurysm of aorta in diseases classified elsewhere
0.000 0.934 0.066
I83.1 Varicose veins of lower extremities with inflammation
0.065 0.935 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.936 0.063
M45.X2 Ankylosing spondylitis (Cervical region)
0.063 0.937 0.000
I70.9 Generalised and unspecified atherosclerosis
0.000 0.937 0.063
E34.0 Carcinoid syndrome
0.000 0.937 0.063
M45.X6 Ankylosing spondylitis (Lumbar region)
0.062 0.938 0.000
E78.0 Pure hypercholesterolaemia
0.000 0.939 0.061
I70.0 Atherosclerosis of aorta
0.000 0.939 0.061
E29.1 Testicular hypofunction
0.000 0.939 0.061
C25.7 Other parts of pancreas
0.000 0.939 0.061
I70.21 Atherosclerosis of arteries of extremities (with gangrene)
0.000 0.940 0.060
C17.8 Overlapping lesion of small intestine
0.000 0.940 0.060
C17.3 Meckel's diverticulum
0.000 0.940 0.060
E26.8 Other hyperaldosteronism
0.001 0.940 0.059
E26.1 Secondary hyperaldosteronism
0.001 0.940 0.059
E85.9 Amyloidosis, unspecified
0.001 0.940 0.059
C25.9 Pancreas, unspecified
0.000 0.942 0.058
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.942 0.058
E23.7 Disorder of pituitary gland, unspecified
0.000 0.942 0.058
C24.8 Overlapping lesion of biliary tract
0.000 0.942 0.058
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.058 0.942 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.058 0.942 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.058 0.942 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.058 0.942 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.058 0.942 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.058 0.942 0.000
I78 Diseases of capillaries
0.000 0.945 0.055
C24.9 Biliary tract, unspecified
0.000 0.945 0.054
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.000 0.946 0.054
I70.80 Atherosclerosis of other arteries (without gangrene)
0.000 0.946 0.054
C21.2 Cloacogenic zone
0.000 0.946 0.054
C17.1 Jejunum
0.000 0.946 0.054
I77.0 Arteriovenous fistula, acquired
0.000 0.946 0.053
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.946 0.053
E26.9 Hyperaldosteronism, unspecified
0.001 0.947 0.052
I70.10 Atherosclerosis of renal artery (without gangrene)
0.000 0.948 0.052
E22.8 Other hyperfunction of pituitary gland
0.000 0.949 0.051
I74.8 Embolism and thrombosis of other arteries
0.000 0.949 0.051
I70.81 Atherosclerosis of other arteries (with gangrene)
0.000 0.949 0.050
I70.11 Atherosclerosis of renal artery (with gangrene)
0.000 0.950 0.050
C23 Malignant neoplasm of gallbladder
0.000 0.951 0.049
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.951 0.049
E80.2 Other porphyria
0.001 0.951 0.048
E22.1 Hyperprolactinaemia
0.000 0.951 0.048
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.952 0.048
E23.1 Drug-induced hypopituitarism
0.000 0.952 0.048
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.952 0.048
I78.0 Hereditary haemorrhagic telangiectasia
0.000 0.952 0.048
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.953 0.047
C21.0 Anus, unspecified
0.000 0.953 0.047
C21.1 Anal canal
0.000 0.954 0.046
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.954 0.045
E80.5 Crigler-Najjar syndrome
0.001 0.954 0.045
E80.3 Defects of catalase and peroxydase
0.001 0.954 0.045
E80.0 Hereditary erythropoietic porphyria
0.001 0.954 0.045
I70.91 Generalized and unspecified atherosclerosis (with gangrene)
0.000 0.954 0.045
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.045 0.955 0.000
E83.5 Disorders of calcium metabolism
0.005 0.955 0.040
I70.01 Atherosclerosis of aorta (with gangrene)
0.000 0.956 0.044
I70.90 Generalized and unspecified atherosclerosis (without gangrene)
0.000 0.958 0.042
E04 Other non-toxic goitre
0.002 0.958 0.039
C17.9 Small intestine, unspecified
0.000 0.960 0.040
C17.2 Ileum
0.000 0.960 0.039
E80.6 Other disorders of bilirubin metabolism
0.001 0.961 0.038
C26.8 Overlapping lesion of digestive system
0.000 0.961 0.038
C26.1 Spleen
0.000 0.961 0.038
E80.1 Porphyria cutanea tarda
0.001 0.962 0.037
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.962 0.038
I70.00 Atherosclerosis of aorta (without gangrene)
0.000 0.962 0.038
I78.8 Other diseases of capillaries
0.000 0.963 0.037
C22.9 Liver, unspecified
0.000 0.965 0.035
C22.7 Other specified carcinomas of liver
0.000 0.965 0.035
C22.4 Other sarcomas of liver
0.000 0.965 0.035
C22.3 Angiosarcoma of liver
0.000 0.965 0.035

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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