TreeWAS – Variant ID: rs12477314

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.940	0.060	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.938	0.062	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.931	0.069	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.914	0.086	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.899	0.101	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.875	0.125	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.849	0.151	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.835	0.165	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.825	0.175	0.000
T43.6 Psychostimulants with abuse potential	0.807	0.193	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.790	0.210	0.000
T45.0 Antiallergic and antiemetic drugs	0.778	0.222	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.762	0.238	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.761	0.239	0.000
T36 Poisoning by systemic antibiotics	0.753	0.247	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.739	0.261	0.000
T42.4 Benzodiazepines	0.738	0.262	0.000
T45.2 Vitamins, not elsewhere classified	0.729	0.271	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.723	0.277	0.000
T50.4 Drugs affecting uric acid metabolism	0.721	0.278	0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics	0.718	0.282	0.000
T50.8 Diagnostic agents	0.700	0.300	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.682	0.318	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.682	0.318	0.000
T43.9 Psychotropic drug, unspecified	0.674	0.326	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.674	0.326	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.674	0.326	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.673	0.327	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.672	0.327	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.652	0.348	0.000
T50.7 Analeptics and opioid receptor antagonists	0.644	0.356	0.000
T50.6 Antidotes and chelating agents, not elsewhere classified	0.644	0.356	0.000
T50.5 Appetite depressants	0.644	0.356	0.000
T50.3 Electrolytic, caloric and water-balance agents	0.644	0.356	0.000
T50.1 Loop [high-ceiling] diuretics	0.644	0.356	0.000
T50.0 Mineralocorticoids and their antagonists	0.644	0.356	0.000
T47.2 Stimulant laxatives	0.644	0.356	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.642	0.358	0.000
T41.2 Other and unspecified general anaesthetics	0.634	0.366	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.627	0.373	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.627	0.373	0.000
T42.3 Barbiturates	0.627	0.373	0.000
T42.2 Succinimides and oxazolidinediones	0.627	0.373	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.627	0.373	0.000
T36.0 Penicillins	0.621	0.379	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.612	0.388	0.000
T45.9 Primarily systemic and haematological agent, unspecified	0.609	0.391	0.000
T45.8 Other primarily systemic and haematological agents	0.609	0.391	0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants	0.609	0.391	0.000
T45.6 Fibrinolysis-affecting drugs	0.609	0.391	0.000
T45.4 Iron and its compounds	0.609	0.391	0.000
T45.3 Enzymes, not elsewhere classified	0.609	0.391	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.605	0.395	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.586	0.414	0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified	0.577	0.423	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.576	0.424	0.000
T46.1 Calcium-channel blockers	0.571	0.429	0.000
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified	0.567	0.433	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.566	0.434	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.566	0.434	0.000
T47.7 Emetics	0.566	0.434	0.000
T47.6 Antidiarrhoeal drugs	0.566	0.434	0.000
T47.5 Digestants	0.566	0.434	0.000
T47.4 Other laxatives	0.566	0.434	0.000
T47.3 Saline and osmotic laxatives	0.566	0.434	0.000
T47.0 Histamine H(2)-receptor antagonists	0.566	0.434	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.559	0.441	0.000
T42.1 Iminostilbenes	0.548	0.452	0.000
T41.5 Therapeutic gases	0.545	0.454	0.000
T41.4 Anaesthetic, unspecified	0.545	0.454	0.000
T41.3 Local anaesthetics	0.545	0.454	0.000
T41.1 Intravenous anaesthetics	0.545	0.454	0.000
T41.0 Inhaled anaesthetics	0.545	0.454	0.000
T40.4 Other synthetic narcotics	0.545	0.455	0.000
T36.9 Systemic antibiotic, unspecified	0.540	0.460	0.000
T36.8 Other systemic antibiotics	0.540	0.460	0.000
T36.7 Antifungal antibiotics, systemically used	0.540	0.460	0.000
T36.6 Rifamycins	0.540	0.460	0.000
T36.5 Aminoglycosides	0.540	0.460	0.000
T36.4 Tetracyclines	0.540	0.460	0.000
T36.3 Macrolides	0.540	0.460	0.000
T36.2 Chloramphenicol group	0.540	0.460	0.000
T36.1 Cefalosporins and other Beta-lactam antibiotics	0.540	0.460	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.535	0.465	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.530	0.470	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.530	0.470	0.000
T46.7 Peripheral vasodilators	0.530	0.470	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.530	0.470	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.530	0.470	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.530	0.470	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.530	0.470	0.000
T39.0 Salicylates	0.521	0.479	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.520	0.480	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.518	0.482	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.518	0.482	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.518	0.482	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.518	0.482	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.518	0.482	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.518	0.482	0.000
T44.0 Anticholinesterase agents	0.518	0.482	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.514	0.486	0.000
T38.1 Thyroid hormones and substitutes	0.513	0.487	0.000
T42.0 Hydantoin derivatives	0.511	0.488	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.498	0.501	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.492	0.507	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.489	0.511	0.000
T48.5 Anti-common-cold drugs	0.489	0.511	0.000
T48.4 Expectorants	0.489	0.511	0.000
T48.3 Antitussives	0.489	0.511	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.489	0.511	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.489	0.511	0.000
T48.0 Oxytocic drugs	0.489	0.511	0.000
T39.4 Antirheumatics, not elsewhere classified	0.489	0.511	0.000
T39.2 Pyrazolone derivatives	0.489	0.511	0.000
T40.5 Cocaine	0.485	0.515	0.000
T38.9 Other and unspecified hormone antagonists	0.482	0.517	0.000
T38.8 Other and unspecified hormones and their synthetic substitutes	0.482	0.517	0.000
T38.7 Androgens and anabolic congeners	0.482	0.517	0.000
T38.5 Other oestrogens and progestogens	0.482	0.517	0.000
T38.4 Oral contraceptives	0.482	0.517	0.000
T38.2 Antithyroid drugs	0.482	0.517	0.000
T38.0 Glucocorticoids and synthetic analogues	0.482	0.517	0.000
T49.9 Topical agent, unspecified	0.482	0.518	0.000
T49.8 Other topical agents	0.482	0.518	0.000
T49.7 Dental drugs, topically applied	0.482	0.518	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.482	0.518	0.000
T49.5 Ophthalmological drugs and preparations	0.482	0.518	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.482	0.518	0.000
T49.3 Emollients, demulcents and protectants	0.482	0.518	0.000
T49.2 Local astringents and local detergents	0.482	0.518	0.000
T49.1 Antipruritics	0.482	0.518	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.482	0.518	0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]	0.468	0.532	0.000
T40.8 Lysergide [LSD]	0.468	0.532	0.000
T40.7 Cannabis (derivatives)	0.468	0.532	0.000
T40.3 Methadone	0.468	0.532	0.000
T40.1 Heroin	0.468	0.532	0.000
T40.0 Opium	0.468	0.532	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.460	0.540	0.000
T37.5 Antiviral drugs	0.460	0.540	0.000
T37.4 Anthelminthics	0.460	0.540	0.000
T37.3 Other antiprotozoal drugs	0.460	0.540	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.460	0.540	0.000
T37.1 Antimycobacterial drugs	0.460	0.540	0.000
T37.0 Sulphonamides	0.460	0.540	0.000
T43.2 Other and unspecified antidepressants	0.453	0.547	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.429	0.570	0.000
T45.5 Anticoagulants	0.421	0.578	0.001
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.421	0.578	0.000
T40.6 Other and unspecified narcotics	0.393	0.606	0.000
T40.2 Other opioids	0.375	0.625	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.264	0.735	0.001
T39.1 4-Aminophenol derivatives	0.154	0.846	0.000
C20 Malignant neoplasm of rectum	0.000	0.939	0.061
C15.5 Lower third of oesophagus	0.000	0.962	0.038
C15 Malignant neoplasm of oesophagus	0.000	0.964	0.036
C15-C26 Malignant neoplasms of digestive organs	0.000	0.966	0.034
C22 Malignant neoplasm of liver and intrahepatic bile ducts	0.000	0.967	0.033
C22.0 Liver cell carcinoma	0.000	0.968	0.032
C15.9 Oesophagus, unspecified	0.000	0.970	0.030
C15.4 Middle third of oesophagus	0.000	0.971	0.029
C22.9 Liver, unspecified	0.000	0.972	0.028
C15.8 Overlapping lesion of oesophagus	0.000	0.974	0.026
C15.2 Abdominal part of oesophagus	0.000	0.974	0.026
C15.1 Thoracic part of oesophagus	0.000	0.974	0.026
C15.0 Cervical part of oesophagus	0.000	0.974	0.026
C23 Malignant neoplasm of gallbladder	0.000	0.975	0.025
C21 Malignant neoplasm of anus and anal canal	0.000	0.976	0.024
C22.7 Other specified carcinomas of liver	0.000	0.976	0.024
C22.4 Other sarcomas of liver	0.000	0.976	0.024
C22.3 Angiosarcoma of liver	0.000	0.976	0.024
C22.2 Hepatoblastoma	0.000	0.976	0.024
C24 Malignant neoplasm of other and unspecified parts of biliary tract	0.000	0.978	0.022
C22.1 Intrahepatic bile duct carcinoma	0.000	0.979	0.021
C26 Malignant neoplasm of other and ill-defined digestive organs	0.000	0.979	0.021
C25 Malignant neoplasm of pancreas	0.000	0.979	0.021
C16 Malignant neoplasm of stomach	0.000	0.979	0.021
F60 Specific personality disorders	0.020	0.980	0.000
F60.9 Personality disorder, unspecified	0.020	0.980	0.000
C15.3 Upper third of oesophagus	0.000	0.981	0.019
C21.1 Anal canal	0.000	0.981	0.019
F60.3 Emotionally unstable personality disorder	0.019	0.981	0.000
C24.9 Biliary tract, unspecified	0.000	0.982	0.018
C21.2 Cloacogenic zone	0.000	0.982	0.018
F60.0 Paranoid personality disorder	0.018	0.982	0.000
C21.8 Overlapping lesion of rectum, anus and anal canal	0.000	0.983	0.017
F60.2 Dissocial personality disorder	0.016	0.983	0.000
C21.0 Anus, unspecified	0.000	0.983	0.016
C24.8 Overlapping lesion of biliary tract	0.000	0.984	0.016
C16.0 Cardia	0.000	0.984	0.016
C25.0 Head of pancreas	0.000	0.984	0.016
F60.6 Anxious [avoidant] personality disorder	0.016	0.984	0.000
C16.6 Greater curvature of stomach, unspecified	0.000	0.984	0.016
C24.1 Ampulla of Vater	0.000	0.984	0.015
C26.8 Overlapping lesion of digestive system	0.000	0.985	0.015
C26.1 Spleen	0.000	0.985	0.015
C25.1 Body of pancreas	0.000	0.985	0.015
C25.8 Overlapping lesion of pancreas	0.000	0.985	0.015
C25.4 Endocrine pancreas	0.000	0.985	0.015
C16.8 Overlapping lesion of stomach	0.000	0.985	0.015
C16.1 Fundus of stomach	0.000	0.985	0.015
F60.7 Dependent personality disorder	0.015	0.985	0.000
C16.5 Lesser curvature of stomach, unspecified	0.000	0.985	0.015
C16.4 Pylorus	0.000	0.985	0.015
F60.8 Other specific personality disorders	0.015	0.985	0.000
F60.4 Histrionic personality disorder	0.015	0.985	0.000
F60.1 Schizoid personality disorder	0.015	0.985	0.000
C16.9 Stomach, unspecified	0.000	0.985	0.015
C25.3 Pancreatic duct	0.000	0.985	0.014
C26.0 Intestinal tract, part unspecified	0.000	0.985	0.014
C25.7 Other parts of pancreas	0.000	0.986	0.014
C17 Malignant neoplasm of small intestine	0.000	0.986	0.014
F60.5 Anankastic personality disorder	0.014	0.986	0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.014	0.986	0.000
C25.2 Tail of pancreas	0.000	0.986	0.014
F60-F69 Disorders of adult personality and behaviour	0.014	0.986	0.000
S92.30 Fracture of metatarsal bone (closed)	0.000	0.986	0.014
C16.2 Body of stomach	0.000	0.986	0.014
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.014	0.986	0.000
C26.9 Ill-defined sites within the digestive system	0.000	0.987	0.013
C25.9 Pancreas, unspecified	0.000	0.987	0.013
G61 Inflammatory polyneuropathy	0.000	0.987	0.013
F69 Unspecified disorder of adult personality and behaviour	0.013	0.987	0.000
G62.8 Other specified polyneuropathies	0.000	0.987	0.013
C24.0 Extrahepatic bile duct	0.000	0.987	0.012
G61.8 Other inflammatory polyneuropathies	0.000	0.987	0.013
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.000	0.988	0.012
G61.0 Guillain-Barre syndrome	0.000	0.988	0.012
G62 Other polyneuropathies	0.000	0.988	0.012
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.012	0.988	0.000
C16.3 Pyloric antrum	0.000	0.988	0.012
S92.3 Fracture of metatarsal bone	0.000	0.988	0.011
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.011	0.989	0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.011	0.989	0.000
T84.2 Mechanical complication of internal fixation device of other bones	0.011	0.989	0.000
C19 Malignant neoplasm of rectosigmoid junction	0.000	0.989	0.011
G60 Hereditary and idiopathic neuropathy	0.000	0.989	0.010
C17.8 Overlapping lesion of small intestine	0.000	0.989	0.010
C17.3 Meckel's diverticulum	0.000	0.989	0.010
G61.9 Inflammatory polyneuropathy, unspecified	0.000	0.990	0.010
G63 Polyneuropathy in diseases classified elsewhere	0.000	0.990	0.010
C17.1 Jejunum	0.000	0.990	0.010
F64 Gender identity disorders	0.010	0.990	0.000
F68 Other disorders of adult personality and behaviour	0.010	0.990	0.000
F66 Psychological and behavioural disorders associated with sexual development and orientation	0.010	0.990	0.000
F65 Disorders of sexual preference	0.010	0.990	0.000
F63 Habit and impulse disorders	0.010	0.990	0.000
F62 Enduring personality changes, not attributable to brain damage and disease	0.010	0.990	0.000
F61 Mixed and other personality disorders	0.010	0.990	0.000
S92 Fracture of foot, except ankle	0.000	0.990	0.010
G61.1 Serum neuropathy	0.000	0.990	0.010
G60.0 Hereditary motor and sensory neuropathy	0.000	0.991	0.009
G63.2 Diabetic polyneuropathy	0.000	0.991	0.009
S92.0 Fracture of calcaneus	0.000	0.991	0.009
C17.9 Small intestine, unspecified	0.000	0.991	0.009
G64 Other disorders of peripheral nervous system	0.000	0.991	0.009
S92.00 Fracture of calcaneus (closed)	0.000	0.991	0.009
G62.2 Polyneuropathy due to other toxic agents	0.000	0.991	0.009
G62.1 Alcoholic polyneuropathy	0.000	0.991	0.009
S92.31 Fracture of metatarsal bone (open)	0.000	0.991	0.008
G62.9 Polyneuropathy, unspecified	0.000	0.992	0.008
C17.2 Ileum	0.000	0.992	0.008
S92.4 Fracture of great toe	0.000	0.992	0.008
S92.2 Fracture of other tarsal bone(s)	0.000	0.992	0.008
C17.0 Duodenum	0.000	0.992	0.008
G60.8 Other hereditary and idiopathic neuropathies	0.000	0.992	0.008
S92.1 Fracture of talus	0.000	0.992	0.008
G60.9 Hereditary and idiopathic neuropathy, unspecified	0.000	0.992	0.008
G60.3 Idiopathic progressive neuropathy	0.000	0.992	0.008
G60.2 Neuropathy in association with hereditary ataxia	0.000	0.992	0.008
G60.1 Refsum's disease	0.000	0.992	0.008
G63.8 Polyneuropathy in other diseases classified elsewhere	0.000	0.992	0.008
G63.6 Polyneuropathy in other musculoskeletal disorders	0.000	0.992	0.008
G63.5 Polyneuropathy in systemic connective tissue disorders	0.000	0.992	0.008
G63.4 Polyneuropathy in nutritional deficiency	0.000	0.992	0.008
G63.3 Polyneuropathy in other endocrine and metabolic diseases	0.000	0.992	0.008
G63.1 Polyneuropathy in neoplastic disease	0.000	0.992	0.008
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere	0.000	0.992	0.008
F62.9 Enduring personality change, unspecified	0.007	0.992	0.000
F62.8 Other enduring personality changes	0.007	0.992	0.000
F62.1 Enduring personality change after psychiatric illness	0.007	0.992	0.000
F62.0 Enduring personality change after catastrophic experience	0.007	0.992	0.000
F63.9 Habit and impulse disorder, unspecified	0.007	0.992	0.000
F63.8 Other habit and impulse disorders	0.007	0.992	0.000
F63.3 Trichotillomania	0.007	0.992	0.000
F63.2 Pathological stealing [kleptomania]	0.007	0.992	0.000
F63.1 Pathological fire-setting [pyromania]	0.007	0.992	0.000
F63.0 Pathological gambling	0.007	0.992	0.000
F64.9 Gender identity disorder, unspecified	0.007	0.992	0.000
F64.8 Other gender identity disorders	0.007	0.992	0.000
F64.2 Gender identity disorder of childhood	0.007	0.992	0.000
F64.1 Dual-role transvestism	0.007	0.992	0.000
F64.0 Transsexualism	0.007	0.992	0.000
F65.9 Disorder of sexual preference, unspecified	0.007	0.992	0.000
F65.8 Other disorders of sexual preference	0.007	0.992	0.000
F65.6 Multiple disorders of sexual preference	0.007	0.992	0.000
F65.5 Sadomasochism	0.007	0.992	0.000
F65.4 Paedophilia	0.007	0.992	0.000
F65.3 Voyeurism	0.007	0.992	0.000
F65.2 Exhibitionism	0.007	0.992	0.000
F65.1 Fetishistic transvestism	0.007	0.992	0.000
F65.0 Fetishism	0.007	0.992	0.000
F66.9 Psychosexual development disorder, unspecified	0.007	0.992	0.000
F66.8 Other psychosexual development disorders	0.007	0.992	0.000
F66.2 Sexual relationship disorder	0.007	0.992	0.000
F66.1 Egodystonic sexual orientation	0.007	0.992	0.000
F66.0 Sexual maturation disorder	0.007	0.992	0.000
F68.8 Other specified disorders of adult personality and behaviour	0.007	0.992	0.000
F68.1 Intentional production or feigning of symptoms or disabilities, either physical or psychological [factitious disorder]	0.007	0.992	0.000
F68.0 Elaboration of physical symptoms for psychological reasons	0.007	0.992	0.000
S92.5 Fracture of other toe	0.000	0.992	0.007
S92.7 Multiple fractures of foot	0.000	0.992	0.007
G62.0 Drug-induced polyneuropathy	0.000	0.993	0.007
S92.9 Fracture of foot, unspecified	0.000	0.993	0.007
S92.40 Fracture of great toe (closed)	0.000	0.993	0.007
S92.01 Fracture of calcaneus (open)	0.000	0.993	0.007
S92.20 Fracture of other tarsal bone(s) (closed)	0.000	0.993	0.007
Z41.1 Other plastic surgery for unacceptable cosmetic appearance	0.007	0.993	0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.006	0.993	0.000
S92.10 Fracture of talus (closed)	0.000	0.994	0.006
S92.50 Fracture of other toe (closed)	0.000	0.994	0.006
T84.3 Mechanical complication of other bone devices, implants and grafts	0.006	0.994	0.000
S92.21 Fracture of other tarsal bone(s) (open)	0.000	0.994	0.006
S92.11 Fracture of talus (open)	0.000	0.994	0.006
S92.70 Multiple fractures of foot (closed)	0.000	0.994	0.006
S92.71 Multiple fractures of foot (open)	0.000	0.994	0.005
S92.91 Fracture of foot, unspecified (open)	0.000	0.994	0.005
S92.90 Fracture of foot, unspecified (closed)	0.000	0.994	0.005
T84.1 Mechanical complication of internal fixation device of bones of limb	0.005	0.994	0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.005	0.995	0.000
S92.41 Fracture of great toe (open)	0.000	0.995	0.005
D86.9 Sarcoidosis, unspecified	0.005	0.995	0.000
Z91.5 Personal history of self-harm	0.005	0.995	0.000
S92.51 Fracture of other toe (open)	0.000	0.995	0.005
H04.5 Stenosis and insufficiency of lachrymal passages	0.000	0.995	0.005
S46.0 Injury of tendon of the rotator cuff of shoulder	0.004	0.996	0.000
L30.8 Other specified dermatitis	0.000	0.996	0.004
Q61.0 Congenital single renal cyst	0.004	0.996	0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)	0.000	0.996	0.004
D63.0 Anaemia in neoplastic disease	0.004	0.996	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.000	0.996	0.003
H02.6 Xanthelasma of eyelid	0.000	0.997	0.003
L81.4 Other melanin hyperpigmentation	0.003	0.997	0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.003	0.997	0.000
H02.5 Other disorders affecting eyelid function	0.000	0.997	0.003
Z41 Procedures for purposes other than remedying health state	0.003	0.997	0.000
M87.95 Osteonecrosis, unspecified (Pelvic region and thigh)	0.000	0.997	0.003
L27.0 Generalised skin eruption due to drugs and medicaments	0.000	0.997	0.003
E11.9 Without complications	0.000	0.997	0.003
N41.0 Acute prostatitis	0.003	0.997	0.000
Z91.8 Personal history of other specified risk-factors, not elsewhere classified	0.003	0.997	0.000
Z91 Personal history of risk-factors, not elsewhere classified	0.003	0.997	0.000
M82.10 Osteoporosis in endocrine disorders (Multiple sites)	0.003	0.997	0.000
F41.2 Mixed anxiety and depressive disorder	0.003	0.997	0.000
Q61 Cystic kidney disease	0.003	0.997	0.000
M82.11 Osteoporosis in endocrine disorders (Shoulder region)	0.003	0.997	0.000
R93.4 Abnormal findings on diagnostic imaging of urinary organs	0.000	0.997	0.003
I22.1 Subsequent myocardial infarction of inferior wall	0.000	0.997	0.003
N41.9 Inflammatory disease of prostate, unspecified	0.003	0.997	0.000
Q61.4 Renal dysplasia	0.003	0.997	0.000
H02.3 Blepharochalasis	0.000	0.997	0.003
D86 Sarcoidosis	0.003	0.997	0.000
D86.8 Sarcoidosis of other and combined sites	0.003	0.997	0.000
I22.8 Subsequent myocardial infarction of other sites	0.000	0.997	0.003
M96.0 Pseudarthrosis after fusion or arthrodesis	0.003	0.997	0.000
Z41.8 Other procedures for purposes other than remedying health state	0.003	0.997	0.000
I22 Subsequent myocardial infarction	0.000	0.997	0.003
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.003	0.997	0.000
L27 Dermatitis due to substances taken internally	0.000	0.997	0.003
Q61.2 Polycystic kidney, adult type	0.003	0.997	0.000
T84.0 Mechanical complication of internal joint prosthesis	0.003	0.997	0.000
M82.1 Osteoporosis in endocrine disorders	0.003	0.997	0.000
Z41.9 Procedures for purposes other than remedying health state, unspecified	0.002	0.997	0.000
Z41.3 Ear piercing	0.002	0.997	0.000
Z41.0 Hair transplant	0.002	0.997	0.000
H02 Other disorders of eyelid	0.000	0.997	0.003
M54.22 Cervicalgia (Cervical region)	0.003	0.997	0.000
Z41.2 Routine and ritual circumcision	0.002	0.997	0.000
M48.06 Spinal stenosis (Lumbar region)	0.000	0.997	0.003
L29.0 Pruritus ani	0.000	0.998	0.002
Z91.0 Personal history of allergy, other than to drugs and biological substances	0.002	0.998	0.000
Z91.7 Personal history of female genital mutilation	0.002	0.998	0.000
Z91.4 Personal history of psychological trauma, not elsewhere classified	0.002	0.998	0.000
Z91.3 Personal history of unhealthy sleep-wake schedule	0.002	0.998	0.000
G91.1 Obstructive hydrocephalus	0.002	0.998	0.000
N41 Inflammatory diseases of prostate	0.002	0.998	0.000
H02.1 Ectropion of eyelid	0.000	0.998	0.002
L27.1 Localised skin eruption due to drugs and medicaments	0.000	0.998	0.002
S90.8 Other superficial injuries of ankle and foot	0.002	0.998	0.000
C45.0 Mesothelioma of pleura	0.000	0.998	0.002
Z91.2 Personal history of poor personal hygiene	0.002	0.998	0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.002	0.998	0.000
S12.20 Fracture of other specified cervical vertebra (closed)	0.002	0.998	0.000
L30 Other dermatitis	0.000	0.998	0.002
Q61.9 Cystic kidney disease, unspecified	0.002	0.998	0.000
Q61.8 Other cystic kidney diseases	0.002	0.998	0.000
Q61.1 Polycystic kidney, infantile type	0.002	0.998	0.000
H02.2 Lagophthalmos	0.000	0.998	0.002
H04.2 Epiphora	0.000	0.998	0.002
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.002	0.998	0.000
Z91.1 Personal history of noncompliance with medical treatment and regimen	0.002	0.998	0.000
S82.30 Fracture of lower end of tibia (closed)	0.002	0.998	0.000
N41.8 Other inflammatory diseases of prostate	0.002	0.998	0.000
S01.5 Open wound of lip and oral cavity	0.002	0.998	0.000
L29 Pruritus	0.000	0.998	0.002
H02.4 Ptosis of eyelid	0.000	0.998	0.002
L27.9 Dermatitis due to unspecified substance taken internally	0.000	0.998	0.002
L27.8 Dermatitis due to other substances taken internally	0.000	0.998	0.002
H04 Disorders of lachrymal system	0.000	0.998	0.002
M54.23 Cervicalgia (Cervicothoracic region)	0.002	0.998	0.000
F06.7 Mild cognitive disorder	0.002	0.998	0.000
M23.3 Other meniscus derangements	0.002	0.998	0.000
Z91.6 Personal history of other physical trauma	0.002	0.998	0.000
M82.19 Osteoporosis in endocrine disorders (Site unspecified)	0.002	0.998	0.000
M82.18 Osteoporosis in endocrine disorders (Other)	0.002	0.998	0.000
M82.17 Osteoporosis in endocrine disorders (Ankle and foot)	0.002	0.998	0.000
M82.16 Osteoporosis in endocrine disorders (Lower leg)	0.002	0.998	0.000
M82.15 Osteoporosis in endocrine disorders (Pelvic region and thigh)	0.002	0.998	0.000
M82.14 Osteoporosis in endocrine disorders (Hand)	0.002	0.998	0.000
M82.13 Osteoporosis in endocrine disorders (Forearm)	0.002	0.998	0.000
M82.12 Osteoporosis in endocrine disorders (Upper arm)	0.002	0.998	0.000
D86.3 Sarcoidosis of skin	0.002	0.998	0.000
H02.7 Other degenerative disorders of eyelid and periocular area	0.000	0.998	0.002
M31.4 Aortic arch syndrome [Takayasu]	0.002	0.998	0.000
Q61.5 Medullary cystic kidney	0.002	0.998	0.000
L27.2 Dermatitis due to ingested food	0.000	0.998	0.002
M54.29 Cervicalgia-Site unspe	0.002	0.998	0.000
M54.2 Cervicalgia	0.002	0.998	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.002	0.998	0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.002	0.998	0.000
L20-L30 Dermatitis and eczema	0.000	0.998	0.002
X60.8 Other specified place	0.002	0.998	0.000
S10.9 Superficial injury of neck, part unspecified	0.002	0.998	0.000
S46 Injury of muscle and tendon at shoulder and upper arm level	0.002	0.998	0.000
S90 Superficial injury of ankle and foot	0.002	0.998	0.001
F41.1 Generalised anxiety disorder	0.002	0.998	0.000
N41.3 Prostatocystitis	0.002	0.998	0.000
N41.2 Abscess of prostate	0.002	0.998	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.002	0.998	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.000	0.998	0.002
N80.1 Endometriosis of ovary	0.000	0.998	0.002
Q61.3 Polycystic kidney, unspecified	0.002	0.998	0.000
L21 Seborrhoeic dermatitis	0.000	0.998	0.002
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.002	0.998	0.000
L21.9 Seborrhoeic dermatitis, unspecified	0.000	0.998	0.002
L30.5 Pityriasis alba	0.000	0.998	0.002
L30.3 Infective dermatitis	0.000	0.998	0.002
L30.2 Cutaneous autosensitisation	0.000	0.998	0.002
L30.1 Dyshidrosis [pompholyx]	0.000	0.998	0.002
L30.0 Nummular dermatitis	0.000	0.998	0.002
M96.1 Postlaminectomy syndrome, not elsewhere classified	0.002	0.998	0.000
M31.3 Wegener's granulomatosis	0.002	0.998	0.000
M31 Other necrotising vasculopathies	0.002	0.998	0.000
M90.71 Fracture of bone in neoplastic disease (Shoulder region)	0.002	0.998	0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.002	0.998	0.000
L29.9 Pruritus, unspecified	0.000	0.998	0.002
J98.0 Diseases of bronchus, not elsewhere classified	0.000	0.998	0.002
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.000	0.998	0.002
M23.30 Other meniscus derangements (Multiple sites)	0.002	0.998	0.000
L50.9 Urticaria, unspecified	0.000	0.998	0.002
S12.2 Fracture of other specified cervical vertebra	0.002	0.998	0.000
S46.1 Injury of muscle and tendon of long head of biceps	0.002	0.998	0.000
S90-S99 Injuries to the ankle and foot	0.000	0.998	0.002
D63.8 Anaemia in other chronic diseases classified elsewhere	0.002	0.998	0.000
D86.0 Sarcoidosis of lung	0.002	0.998	0.000
S90.9 Superficial injury of ankle and foot, unspecified	0.002	0.998	0.000
S90.0 Contusion of ankle	0.002	0.998	0.000
M90.75 Fracture of bone in neoplastic disease (Pelvic region and thigh)	0.002	0.998	0.000
C45.9 Mesothelioma, unspecified	0.000	0.998	0.002
K35.1 Acute appendicitis with peritoneal abscess	0.000	0.998	0.002
L29.3 Anogenital pruritus, unspecified	0.000	0.998	0.002
L29.1 Pruritus scroti	0.000	0.998	0.002
M23.37 Other meniscus derangements-Capsular lig	0.002	0.998	0.000
H04.9 Disorder of lachrymal system, unspecified	0.000	0.998	0.002
H04.8 Other disorders of lachrymal system	0.000	0.998	0.002
H04.0 Dacryoadenitis	0.000	0.998	0.002
N41.1 Chronic prostatitis	0.002	0.998	0.000
S72.20 Subtrochanteric fracture (closed)	0.000	0.998	0.002
S93.3 Dislocation of other and unspecified parts of foot	0.000	0.998	0.002
L30.4 Erythema intertrigo	0.000	0.998	0.002
M31.7 Microscopic polyangiitis	0.002	0.998	0.000
M90.7 Fracture of bone in neoplastic disease	0.002	0.998	0.000
C02.4 Lingual tonsil	0.002	0.998	0.000
H04.3 Acute and unspecified inflammation of lachrymal passages	0.000	0.998	0.002
J38.3 Other diseases of vocal cords	0.000	0.998	0.002
V89.2 Person injured in unspecified motor-vehicle accident, traffic	0.002	0.998	0.000
M54.28 Cervicalgia-Sacral/sacrococ	0.002	0.998	0.000
M54.27 Cervicalgia-Lumbosacral	0.002	0.998	0.000
M54.26 Cervicalgia-Lumbar	0.002	0.998	0.000
M54.25 Cervicalgia-Thoracolumbar	0.002	0.998	0.000
M54.24 Cervicalgia-Thoracic	0.002	0.998	0.000
M54.21 Cervicalgia (Occipito-atlanto-axial region)	0.002	0.998	0.000
M54.20 Cervicalgia-Mult site	0.002	0.998	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.002	0.998	0.000
H04.6 Other changes in lachrymal passages	0.000	0.998	0.002
L29.8 Other pruritus	0.000	0.998	0.002
S90.1 Contusion of toe(s) without damage to nail	0.001	0.998	0.000
S93.1 Dislocation of toe(s)	0.000	0.998	0.002
L24 Irritant contact dermatitis	0.000	0.998	0.002
L26 Exfoliative dermatitis	0.000	0.998	0.002

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations