TreeWAS – Variant ID: rs12866352

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M20-M25 Other joint disorders	0.768	0.232	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.768	0.232	0.000
Chapter V Mental and behavioural disorders	0.765	0.235	0.000
# Top node	0.765	0.235	0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.749	0.251	0.000
M23 Internal derangement of knee	0.744	0.256	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.742	0.258	0.000
F30-F39 Mood [affective] disorders	0.738	0.262	0.000
Chapter VIII Diseases of the ear and mastoid process	0.728	0.272	0.000
M25 Other joint disorders, not elsewhere classified	0.727	0.273	0.000
F20 Schizophrenia	0.722	0.278	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.717	0.283	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.710	0.290	0.000
F31 Bipolar affective disorder	0.708	0.292	0.000
M05-M14 Inflammatory polyarthropathies	0.705	0.295	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.705	0.295	0.000
M23.2 Derangement of meniscus due to old tear or injury	0.688	0.312	0.000
M15-M19 Arthrosis	0.687	0.313	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.685	0.315	0.000
L40-L45 Papulosquamous disorders	0.684	0.316	0.000
M25.5 Pain in joint	0.683	0.317	0.000
F33 Recurrent depressive disorder	0.678	0.322	0.000
Chapter I Certain infectious and parasitic diseases	0.674	0.326	0.000
F20.9 Schizophrenia, unspecified	0.673	0.327	0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.671	0.329	0.000
M23.3 Other meniscus derangements	0.667	0.333	0.000
H65-H75 Diseases of middle ear and mastoid	0.666	0.334	0.000
M35 Other systemic involvement of connective tissue	0.665	0.335	0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.662	0.338	0.000
M21 Other acquired deformities of limbs	0.658	0.342	0.000
H90-H95 Other disorders of ear	0.657	0.343	0.000
L40 Psoriasis	0.657	0.343	0.000
L50-L54 Urticaria and erythema	0.657	0.343	0.000
Chapter X Diseases of the respiratory system	0.652	0.348	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.650	0.350	0.000
M16 Coxarthrosis [arthrosis of hip]	0.650	0.350	0.000
M25.54 Pain in joint (Hand)	0.646	0.354	0.000
M13 Other arthritis	0.644	0.356	0.000
F20.0 Paranoid schizophrenia	0.638	0.362	0.000
F00-F09 Organic, including symptomatic, mental disorders	0.638	0.362	0.000
F31.9 Bipolar affective disorder, unspecified	0.637	0.363	0.000
L20-L30 Dermatitis and eczema	0.634	0.366	0.000
L40.5 Arthropathic psoriasis	0.632	0.368	0.000
F33.9 Recurrent depressive disorder, unspecified	0.631	0.369	0.000
M80-M85 Disorders of bone density and structure	0.630	0.370	0.000
J80-J84 Other respiratory diseases principally affecting the interstitium	0.628	0.372	0.000
L00-L08 Infections of the skin and subcutaneous tissue	0.628	0.372	0.000
F60-F69 Disorders of adult personality and behaviour	0.624	0.376	0.000
M86-M90 Other osteopathies	0.616	0.384	0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)	0.614	0.386	0.000
M16.9 Coxarthrosis, unspecified	0.612	0.388	0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.610	0.390	0.000
H90 Conductive and sensorineural hearing loss	0.610	0.390	0.000
F25 Schizoaffective disorders	0.610	0.390	0.000
A30-A49 Other bacterial diseases	0.609	0.391	0.000
M13.9 Arthritis, unspecified	0.606	0.394	0.000
Q60-Q64 Congenital malformations of the urinary system	0.604	0.396	0.000
M13.99 Arthritis, unspecified (Site unspecified)	0.597	0.403	0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts	0.597	0.403	0.000
F22 Persistent delusional disorders	0.596	0.404	0.000
M30 Polyarteritis nodosa and related conditions	0.594	0.406	0.000
Chapter II Neoplasms	0.594	0.406	0.000
M25.59 Pain in joint (Site unspecified)	0.593	0.407	0.000
J30-J39 Other diseases of upper respiratory tract	0.592	0.408	0.000
M35.3 Polymyalgia rheumatica	0.590	0.410	0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)	0.590	0.410	0.000
M25.4 Effusion of joint	0.589	0.411	0.000
H72 Perforation of tympanic membrane	0.589	0.411	0.000
T84.0 Mechanical complication of internal joint prosthesis	0.588	0.412	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.586	0.414	0.000
M23.4 Loose body in knee	0.584	0.416	0.000
M91-M94 Chondropathies	0.584	0.416	0.000
Chapter VI Diseases of the nervous system	0.581	0.419	0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.581	0.419	0.000
M25.7 Osteophyte	0.580	0.420	0.000
M60-M63 Disorders of muscles	0.580	0.420	0.000
J32 Chronic sinusitis	0.579	0.421	0.000
F31.0 Bipolar affective disorder, current episode hypomanic	0.578	0.422	0.000
H71 Cholesteatoma of middle ear	0.578	0.422	0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.577	0.423	0.000
T82.4 Mechanical complication of vascular dialysis catheter	0.577	0.423	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.575	0.425	0.000
M23.5 Chronic instability of knee	0.575	0.425	0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.575	0.425	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.575	0.425	0.000
L02 Cutaneous abscess, furuncle and carbuncle	0.573	0.427	0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms	0.571	0.429	0.000
J84 Other interstitial pulmonary diseases	0.571	0.429	0.000
M25.52 Pain in joint (Upper arm)	0.570	0.430	0.000
M06 Other rheumatoid arthritis	0.568	0.432	0.000
S90-S99 Injuries to the ankle and foot	0.566	0.434	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.563	0.437	0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts	0.562	0.438	0.000
C34 Malignant neoplasm of bronchus and lung	0.562	0.438	0.000
J81 Pulmonary oedema	0.559	0.441	0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.557	0.443	0.000
M07 Psoriatic and enteropathic arthropathies	0.557	0.443	0.000
Q00-Q07 Congenital malformations of the nervous system	0.557	0.443	0.000
M16.3 Other dysplastic coxarthrosis	0.556	0.444	0.000
F23 Acute and transient psychotic disorders	0.556	0.444	0.000
L53 Other erythematous conditions	0.554	0.446	0.000
M65-M68 Disorders of synovium and tendon	0.554	0.446	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.552	0.448	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.551	0.449	0.000
M34 Systemic sclerosis	0.551	0.449	0.000
M33 Dermatopolymyositis	0.551	0.449	0.000
M32 Systemic lupus erythematosus	0.551	0.449	0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.549	0.451	0.000
F70-F79 Mental retardation	0.549	0.451	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.548	0.452	0.000
A49 Bacterial infection of unspecified site	0.548	0.452	0.000
M25.56 Pain in joint (Lower leg)	0.548	0.452	0.000
L02.3 Cutaneous abscess, furuncle and carbuncle of buttock	0.547	0.453	0.000
F80-F89 Disorders of psychological development	0.547	0.453	0.000
L40.0 Psoriasis vulgaris	0.547	0.453	0.000
L50 Urticaria	0.546	0.454	0.000
T91 Sequelae of injuries of neck and trunk	0.546	0.454	0.000
A80-A89 Viral infections of the central nervous system	0.545	0.455	0.000
C34.9 Bronchus or lung, unspecified	0.545	0.455	0.000
M14 Arthropathies in other diseases classified elsewhere	0.544	0.456	0.000
L30 Other dermatitis	0.544	0.456	0.000
T92 Sequelae of injuries of upper limb	0.542	0.458	0.000
M25.50 Pain in joint (Multiple sites)	0.542	0.458	0.000
J32.0 Chronic maxillary sinusitis	0.541	0.459	0.000
H60-H62 Diseases of external ear	0.540	0.459	0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression	0.540	0.460	0.000
M00-M03 Infectious arthropathies	0.540	0.460	0.000
M84 Disorders of continuity of bone	0.539	0.460	0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms	0.538	0.462	0.000
Chapter XXII Codes for special purposes	0.538	0.462	0.000
H91 Other hearing loss	0.538	0.462	0.000
F29 Unspecified nonorganic psychosis	0.537	0.463	0.000
F28 Other nonorganic psychotic disorders	0.537	0.463	0.000
F24 Induced delusional disorder	0.537	0.463	0.000
F21 Schizotypal disorder	0.537	0.463	0.000
Q50-Q56 Congenital malformations of genital organs	0.535	0.464	0.000
T84.2 Mechanical complication of internal fixation device of other bones	0.535	0.465	0.000
M23.9 Internal derangement of knee, unspecified	0.533	0.466	0.000
M23.6 Other spontaneous disruption of ligament(s) of knee	0.533	0.466	0.000
M23.1 Discoid meniscus (congenital)	0.533	0.466	0.000
M23.0 Cystic meniscus	0.533	0.466	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.532	0.467	0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.532	0.468	0.000
L10-L14 Bullous disorders	0.532	0.468	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.532	0.468	0.000
B15-B19 Viral hepatitis	0.532	0.468	0.000
F00 Dementia in Alzheimer's disease	0.531	0.469	0.000
G50-G59 Nerve, nerve root and plexus disorders	0.531	0.469	0.000
F38 Other mood [affective] disorders	0.529	0.471	0.000
F34 Persistent mood [affective] disorders	0.529	0.471	0.000
F30 Manic episode	0.529	0.471	0.000
F39 Unspecified mood [affective] disorder	0.529	0.471	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.529	0.471	0.000
F99-F99 Unspecified mental disorder	0.528	0.471	0.000
M25.76 Osteophyte (Lower leg)	0.528	0.472	0.000
M31 Other necrotising vasculopathies	0.526	0.474	0.000
Chapter XX External causes of morbidity and mortality	0.526	0.474	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.525	0.475	0.000
T80 Complications following infusion, transfusion and therapeutic injection	0.524	0.475	0.000
Q80-Q89 Other congenital malformations	0.524	0.476	0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.523	0.476	0.000
F60 Specific personality disorders	0.523	0.477	0.000
L60-L75 Disorders of skin appendages	0.522	0.477	0.000
M25.9 Joint disorder, unspecified	0.522	0.478	0.000
M25.3 Other instability of joint	0.522	0.478	0.000
M25.2 Flail joint	0.522	0.478	0.000
M25.1 Fistula of joint	0.522	0.478	0.000
M25.0 Haemarthrosis	0.522	0.478	0.000
T79-T79 Certain early complications of trauma	0.521	0.479	0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.521	0.479	0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.519	0.481	0.000
M21.3 Wrist or foot drop (acquired)	0.518	0.482	0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants	0.518	0.482	0.000
F20.8 Other schizophrenia	0.517	0.483	0.000
F20.6 Simple schizophrenia	0.517	0.483	0.000
F20.5 Residual schizophrenia	0.517	0.483	0.000
F20.4 Postschizophrenic depression	0.517	0.483	0.000
F20.3 Undifferentiated schizophrenia	0.517	0.483	0.000
F20.2 Catatonic schizophrenia	0.517	0.483	0.000
F20.1 Hebephrenic schizophrenia	0.517	0.483	0.000
M89 Other disorders of bone	0.517	0.483	0.000
M17 Gonarthrosis [arthrosis of knee]	0.516	0.484	0.000
M11 Other crystal arthropathies	0.515	0.485	0.000
T33-T35 Frostbite	0.514	0.486	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.514	0.486	0.000
T00-T07 Injuries involving multiple body regions	0.514	0.486	0.000
S10-S19 Injuries to the neck	0.514	0.486	0.000
T86 Failure and rejection of transplanted organs and tissues	0.512	0.488	0.000
T87 Complications peculiar to reattachment and amputation	0.511	0.489	0.000
F25.9 Schizoaffective disorder, unspecified	0.510	0.490	0.000
T85 Complications of other internal prosthetic devices, implants and grafts	0.510	0.490	0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.510	0.490	0.000
M21.6 Other acquired deformities of ankle and foot	0.509	0.491	0.000
L05 Pilonidal cyst	0.509	0.491	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.509	0.491	0.000
L25 Unspecified contact dermatitis	0.509	0.491	0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.509	0.491	0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.509	0.491	0.000
Q35-Q37 Cleft lip and cleft palate	0.509	0.491	0.000
Q30-Q34 Congenital malformations of the respiratory system	0.509	0.491	0.000
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.509	0.491	0.000
M16.1 Other primary coxarthrosis	0.509	0.491	0.000
F33.1 Recurrent depressive disorder, current episode moderate	0.508	0.492	0.000
H70 Mastoiditis and related conditions	0.507	0.492	0.000
F31.8 Other bipolar affective disorders	0.507	0.493	0.000
F31.7 Bipolar affective disorder, currently in remission	0.507	0.493	0.000
F31.6 Bipolar affective disorder, current episode mixed	0.507	0.493	0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms	0.507	0.493	0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms	0.507	0.493	0.000
B65-B83 Helminthiases	0.507	0.493	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.507	0.493	0.000
H90.2 Conductive hearing loss, unspecified	0.506	0.494	0.000
M12 Other specific arthropathies	0.505	0.494	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.505	0.494	0.000
M08 Juvenile arthritis	0.505	0.494	0.000
G90-G99 Other disorders of the nervous system	0.505	0.495	0.000
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms	0.505	0.495	0.000
J32.9 Chronic sinusitis, unspecified	0.502	0.498	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.502	0.498	0.000
M20 Acquired deformities of fingers and toes	0.502	0.498	0.000
T88 Other complications of surgical and medical care, not elsewhere classified	0.500	0.500	0.000
B20-B24 Human immunodeficiency virus [HIV] disease	0.500	0.500	0.000
M13.98 Arthritis, unspecified (Other)	0.499	0.501	0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.498	0.501	0.000
J60-J70 Lung diseases due to external agents	0.497	0.503	0.000
S30 Superficial injury of abdomen, lower back and pelvis	0.497	0.503	0.000
B95-B98 Bacterial, viral and other infectious agents	0.497	0.503	0.000
H90.3 Sensorineural hearing loss, bilateral	0.496	0.504	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.496	0.504	0.000
L29 Pruritus	0.496	0.504	0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.496	0.504	0.000
Q63 Other congenital malformations of kidney	0.495	0.505	0.000
B35-B49 Mycoses	0.495	0.505	0.000
S50-S59 Injuries to the elbow and forearm	0.495	0.505	0.000
J84.1 Other interstitial pulmonary diseases with fibrosis	0.494	0.506	0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.494	0.506	0.000
C34.2 Middle lobe, bronchus or lung	0.493	0.507	0.000
M15 Polyarthrosis	0.493	0.507	0.000
M70-M79 Other soft tissue disorders	0.492	0.508	0.000
H72.8 Other perforations of tympanic membrane	0.492	0.508	0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft	0.491	0.509	0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis	0.491	0.509	0.000
T82.3 Mechanical complication of other vascular grafts	0.491	0.509	0.000
T82.0 Mechanical complication of heart valve prosthesis	0.491	0.509	0.000
J82 Pulmonary eosinophilia, not elsewhere classified	0.491	0.509	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.491	0.509	0.000
L44 Other papulosquamous disorders	0.490	0.509	0.000
L41 Parapsoriasis	0.490	0.509	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.490	0.509	0.000
L42 Pityriasis rosea	0.490	0.509	0.000
M25.58 Pain in joint (Other)	0.489	0.510	0.000
M22 Disorders of patella	0.489	0.510	0.000
M24 Other specific joint derangements	0.489	0.510	0.000
F05 Delirium, not induced by alcohol and other psychoactive substances	0.489	0.511	0.000
M40-M43 Deforming dorsopathies	0.486	0.513	0.000
F33.8 Other recurrent depressive disorders	0.486	0.514	0.000
F33.4 Recurrent depressive disorder, currently in remission	0.486	0.514	0.000
F33.0 Recurrent depressive disorder, current episode mild	0.486	0.514	0.000
M16.7 Other secondary coxarthrosis	0.486	0.514	0.000
F22.0 Delusional disorder	0.486	0.514	0.000
T93 Sequelae of injuries of lower limb	0.485	0.515	0.000
H72.0 Central perforation of tympanic membrane	0.484	0.516	0.000
Q61 Cystic kidney disease	0.484	0.516	0.000
B99-B99 Other infectious diseases	0.483	0.516	0.000
B90-B94 Sequelae of infectious and parasitic diseases	0.483	0.516	0.000
B85-B89 Pediculosis, acariasis and other infestations	0.483	0.516	0.000
B50-B64 Protozoal diseases	0.483	0.516	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.483	0.516	0.000
A75-A79 Rickettsioses	0.483	0.516	0.000
A70-A74 Other diseases caused by chlamydiae	0.483	0.516	0.000
A65-A69 Other spirochaetal diseases	0.483	0.516	0.000
A20-A28 Certain zoonotic bacterial diseases	0.483	0.516	0.000
A15-A19 Tuberculosis	0.483	0.516	0.000
M85 Other disorders of bone density and structure	0.483	0.517	0.000
J84.9 Interstitial pulmonary disease, unspecified	0.483	0.517	0.000
H66 Suppurative and unspecified otitis media	0.482	0.518	0.000
M13.94 Arthritis, unspecified (Hand)	0.482	0.518	0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.481	0.519	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.481	0.519	0.000
J33 Nasal polyp	0.481	0.519	0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.480	0.520	0.000
T98 Sequelae of other and unspecified effects of external causes	0.480	0.520	0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.479	0.521	0.000
C64-C68 Malignant neoplasms of urinary tract	0.479	0.521	0.000
M23.37 Other meniscus derangements-Capsular lig	0.478	0.521	0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.478	0.521	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.478	0.522	0.000
M35.0 Sicca syndrome [Sjogren]	0.478	0.522	0.000
M25.46 Effusion of joint (Lower leg)	0.478	0.522	0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.478	0.522	0.000
H74 Other disorders of middle ear and mastoid	0.478	0.522	0.000
H68 Eustachian salpingitis and obstruction	0.478	0.522	0.000
H67 Otitis media in diseases classified elsewhere	0.478	0.522	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.477	0.523	0.000
M35.8 Other specified systemic involvement of connective tissue	0.477	0.523	0.000
M35.7 Hypermobility syndrome	0.477	0.523	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.477	0.523	0.000
M35.5 Multifocal fibrosclerosis	0.477	0.523	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.477	0.523	0.000
M35.2 Behcet's disease	0.477	0.523	0.000
M35.1 Other overlap syndromes	0.477	0.523	0.000
T90 Sequelae of injuries of head	0.476	0.524	0.000
D10-D36 Benign neoplasms	0.476	0.524	0.000
S70-S79 Injuries to the hip and thigh	0.476	0.524	0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.475	0.525	0.000
T84.3 Mechanical complication of other bone devices, implants and grafts	0.475	0.525	0.000
A41 Other septicaemia	0.475	0.525	0.000
D23 Other benign neoplasms of skin	0.475	0.525	0.000
Q20-Q28 Congenital malformations of the circulatory system	0.474	0.526	0.000
M80 Osteoporosis with pathological fracture	0.474	0.526	0.000
J32.8 Other chronic sinusitis	0.473	0.527	0.000
M21.9 Acquired deformity of limb, unspecified	0.472	0.528	0.000
M21.8 Other specified acquired deformities of limbs	0.472	0.528	0.000
M21.7 Unequal limb length (acquired)	0.472	0.528	0.000
M21.4 Flat foot [pes planus] (acquired)	0.472	0.528	0.000
M21.2 Flexion deformity	0.472	0.528	0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.471	0.529	0.000
H94 Other disorders of ear in diseases classified elsewhere	0.471	0.529	0.000
L40.8 Other psoriasis	0.471	0.529	0.000
L40.4 Guttate psoriasis	0.471	0.529	0.000
L40.3 Pustulosis palmaris et plantaris	0.471	0.529	0.000
L40.2 Acrodermatitis continua	0.471	0.529	0.000
L40.1 Generalised pustular psoriasis	0.471	0.529	0.000
L54 Erythema in diseases classified elsewhere	0.471	0.529	0.000
L51 Erythema multiforme	0.471	0.529	0.000
L52 Erythema nodosum	0.471	0.529	0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.470	0.529	0.000
M21.0 Valgus deformity, not elsewhere classified	0.470	0.530	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.470	0.530	0.000
L02.0 Cutaneous abscess, furuncle and carbuncle of face	0.470	0.530	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.470	0.530	0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease	0.469	0.531	0.000
M23.49 Loose body in knee-Unspec lig/men	0.469	0.531	0.000
M06.9 Rheumatoid arthritis, unspecified	0.468	0.532	0.000
G95 Other diseases of spinal cord	0.468	0.532	0.000
M21.1 Varus deformity, not elsewhere classified	0.468	0.532	0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.467	0.533	0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.467	0.533	0.000
A49.8 Other bacterial infections of unspecified site	0.466	0.534	0.000
B25-B34 Other viral diseases	0.466	0.534	0.000
T95 Sequelae of burns, corrosions and frostbite	0.466	0.534	0.000
T94 Sequelae of injuries involving multiple and unspecified body regions	0.466	0.534	0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.466	0.534	0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.466	0.534	0.000
J39 Other diseases of upper respiratory tract	0.466	0.534	0.000
M16.6 Other secondary coxarthrosis, bilateral	0.466	0.534	0.000
M16.5 Other posttraumatic coxarthrosis	0.466	0.534	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.466	0.534	0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.466	0.534	0.000
C45 Mesothelioma	0.465	0.535	0.000
C73 Malignant neoplasm of thyroid gland	0.465	0.535	0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere	0.463	0.537	0.000
A49.1 Streptococcal infection, unspecified	0.463	0.537	0.000
M13.8 Other specified arthritis	0.462	0.538	0.000
M13.1 Monoarthritis, not elsewhere classified	0.462	0.538	0.000
L50.1 Idiopathic urticaria	0.461	0.539	0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.461	0.539	0.000
M25.8 Other specified joint disorders	0.460	0.539	0.000
D24 Benign neoplasm of breast	0.459	0.541	0.000
L30.8 Other specified dermatitis	0.459	0.541	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.459	0.541	0.000
M13.96 Arthritis, unspecified (Lower leg)	0.458	0.542	0.000
T91.8 Sequelae of other specified injuries of neck and trunk	0.458	0.542	0.000
H69 Other disorders of Eustachian tube	0.457	0.542	0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction	0.457	0.543	0.000
F02 Dementia in other diseases classified elsewhere	0.457	0.543	0.000
F09 Unspecified organic or symptomatic mental disorder	0.457	0.543	0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances	0.457	0.543	0.000
Q18 Other congenital malformations of face and neck	0.457	0.543	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.457	0.543	0.000
J32.2 Chronic ethmoidal sinusitis	0.455	0.545	0.000
J80 Adult respiratory distress syndrome	0.455	0.545	0.000
F00.9 Dementia in Alzheimer's disease, unspecified	0.455	0.545	0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms	0.455	0.545	0.000
L24 Irritant contact dermatitis	0.455	0.545	0.000
L23 Allergic contact dermatitis	0.455	0.545	0.000
L21 Seborrhoeic dermatitis	0.455	0.545	0.000
L20 Atopic dermatitis	0.455	0.545	0.000
L26 Exfoliative dermatitis	0.455	0.545	0.000
L22 Diaper [napkin] dermatitis	0.455	0.545	0.000
M17.1 Other primary gonarthrosis	0.454	0.546	0.000
L53.9 Erythematous condition, unspecified	0.454	0.546	0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.453	0.546	0.000
H73 Other disorders of tympanic membrane	0.453	0.547	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.453	0.547	0.000
T23 Burn and corrosion of wrist and hand	0.453	0.547	0.000
F03 Unspecified dementia	0.453	0.547	0.000
M19 Other arthrosis	0.453	0.547	0.000
H91.9 Hearing loss, unspecified	0.452	0.548	0.000
M83 Adult osteomalacia	0.451	0.548	0.000
M82 Osteoporosis in diseases classified elsewhere	0.451	0.548	0.000
H92 Otalgia and effusion of ear	0.451	0.549	0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.451	0.549	0.000
M07.3 Other psoriatic arthropathies	0.451	0.549	0.000
L04 Acute lymphadenitis	0.450	0.550	0.000
L01 Impetigo	0.450	0.550	0.000
L00 Staphylococcal scalded skin syndrome	0.450	0.550	0.000
M88 Paget's disease of bone [osteitis deformans]	0.450	0.550	0.000
T66-T78 Other and unspecified effects of external causes	0.448	0.552	0.000
F68 Other disorders of adult personality and behaviour	0.447	0.552	0.000
F66 Psychological and behavioural disorders associated with sexual development and orientation	0.447	0.552	0.000
F65 Disorders of sexual preference	0.447	0.552	0.000
F64 Gender identity disorders	0.447	0.552	0.000
F63 Habit and impulse disorders	0.447	0.552	0.000
F62 Enduring personality changes, not attributable to brain damage and disease	0.447	0.552	0.000
F69 Unspecified disorder of adult personality and behaviour	0.447	0.552	0.000
F61 Mixed and other personality disorders	0.447	0.552	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.447	0.553	0.000
Q12 Congenital lens malformations	0.447	0.553	0.000
L71 Rosacea	0.446	0.554	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.446	0.554	0.000
M67 Other disorders of synovium and tendon	0.446	0.554	0.000
M62 Other disorders of muscle	0.445	0.555	0.000
H80-H83 Diseases of inner ear	0.445	0.555	0.000
M86 Osteomyelitis	0.445	0.555	0.000
M94 Other disorders of cartilage	0.444	0.556	0.000
S91 Open wound of ankle and foot	0.444	0.556	0.000
M25.51 Pain in joint (Shoulder region)	0.443	0.557	0.000
M05 Seropositive rheumatoid arthritis	0.442	0.558	0.000
M25.47 Effusion of joint (Ankle and foot)	0.442	0.558	0.000
F01 Vascular dementia	0.442	0.558	0.000
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.442	0.558	0.000
M90 Osteopathies in diseases classified elsewhere	0.441	0.558	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.441	0.559	0.000
D23.3 Skin of other and unspecified parts of face	0.441	0.559	0.000
D50-D53 Nutritional anaemias	0.441	0.559	0.000
M23.8 Other internal derangements of knee	0.441	0.559	0.000
H65 Nonsuppurative otitis media	0.441	0.559	0.000
G55.2 Nerve root and plexus compressions in spondylosis	0.440	0.560	0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.440	0.560	0.000
G30-G32 Other degenerative diseases of the nervous system	0.440	0.560	0.000
J33.8 Other polyp of sinus	0.440	0.560	0.000
L53.8 Other specified erythematous conditions	0.440	0.560	0.000
X60-X84 Intentional self-harm	0.440	0.560	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.439	0.561	0.000
H72.9 Perforation of tympanic membrane, unspecified	0.439	0.561	0.000
S20-S29 Injuries to the thorax	0.437	0.561	0.001
D23.1 Skin of eyelid, including canthus	0.438	0.562	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.437	0.563	0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.437	0.563	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.437	0.563	0.000
H90.0 Conductive hearing loss, bilateral	0.437	0.563	0.000
F25.8 Other schizoaffective disorders	0.437	0.563	0.000
F25.2 Schizoaffective disorder, mixed type	0.437	0.563	0.000
F25.1 Schizoaffective disorder, depressive type	0.437	0.563	0.000
F25.0 Schizoaffective disorder, manic type	0.437	0.563	0.000
A48 Other bacterial diseases, not elsewhere classified	0.436	0.563	0.000
A44 Bartonellosis	0.436	0.563	0.000
A43 Nocardiosis	0.436	0.563	0.000
A42 Actinomycosis	0.436	0.563	0.000
A40 Streptococcal septicaemia	0.436	0.563	0.000
A39 Meningococcal infection	0.436	0.563	0.000
A37 Whooping cough	0.436	0.563	0.000
A36 Diphtheria	0.436	0.563	0.000
A32 Listeriosis	0.436	0.563	0.000
A31 Infection due to other mycobacteria	0.436	0.563	0.000
A30 Leprosy [Hansen's disease]	0.436	0.563	0.000
A46 Erysipelas	0.436	0.563	0.000
A38 Scarlet fever	0.436	0.563	0.000
A35 Other tetanus	0.436	0.563	0.000
A34 Obstetrical tetanus	0.436	0.563	0.000
A33 Tetanus neonatorum	0.436	0.563	0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts	0.436	0.564	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.436	0.564	0.000
M84.0 Malunion of fracture	0.434	0.565	0.000
M13.0 Polyarthritis, unspecified	0.434	0.566	0.000
M13.92 Arthritis, unspecified (Upper arm)	0.434	0.566	0.000
J09-J18 Influenza and pneumonia	0.434	0.566	0.000
L60 Nail disorders	0.434	0.566	0.000
G70-G73 Diseases of myoneural junction and muscle	0.434	0.566	0.000
H60 Otitis externa	0.433	0.566	0.000
Q64 Other congenital malformations of urinary system	0.433	0.567	0.000
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.433	0.567	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.433	0.567	0.000
M23.30 Other meniscus derangements (Multiple sites)	0.433	0.567	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.432	0.568	0.000
M13.93 Arthritis, unspecified (Forearm)	0.432	0.568	0.000
A86 Unspecified viral encephalitis	0.432	0.568	0.000
Q53 Undescended testicle	0.432	0.568	0.000
T40.2 Other opioids	0.431	0.569	0.000
J30 Vasomotor and allergic rhinitis	0.431	0.569	0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.431	0.569	0.000
M14.6 Neuropathic arthropathy	0.429	0.571	0.000
V10-V19 Pedal cyclist injured in transport accident	0.429	0.571	0.000
M93 Other osteochondropathies	0.427	0.572	0.000
F22.9 Persistent delusional disorder, unspecified	0.427	0.573	0.000
F22.8 Other persistent delusional disorders	0.427	0.573	0.000
T92.9 Sequelae of unspecified injury of upper limb	0.427	0.573	0.000
Q38 Other congenital malformations of tongue, mouth and pharynx	0.427	0.573	0.000
L30.9 Dermatitis, unspecified	0.427	0.573	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.427	0.573	0.000
Q07 Other congenital malformations of nervous system	0.427	0.573	0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)	0.426	0.574	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.426	0.574	0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.426	0.574	0.000
M30.2 Juvenile polyarteritis	0.426	0.574	0.000
M30.0 Polyarteritis nodosa	0.426	0.574	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.426	0.574	0.000
H90.5 Sensorineural hearing loss, unspecified	0.425	0.575	0.000
A49.9 Bacterial infection, unspecified	0.424	0.575	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations