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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs13195040
log Bayes Factor = 183.66
Chromosome 6   position 27,413,924  (GRCh37) Explore rs13195040 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E10.9 Without complications
1.000 0.000 0.000
K90.0 Coeliac disease
1.000 0.000 0.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
N40 Hyperplasia of prostate
0.000 0.000 1.000
R31 Unspecified haematuria
0.000 0.000 1.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
M20-M25 Other joint disorders
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
K40.9 Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.000 0.000 1.000
D64.9 Anaemia, unspecified
1.000 0.000 0.000
K44.9 Diaphragmatic hernia without obstruction or gangrene
0.000 0.000 1.000
E03 Other hypothyroidism
1.000 0.000 0.000
K40 Inguinal hernia
0.000 0.000 1.000
N40-N51 Diseases of male genital organs
0.000 0.000 1.000
N30-N39 Other diseases of urinary system
0.000 0.000 1.000
D60-D64 Aplastic and other anaemias
1.000 0.000 0.000
K40-K46 Hernia
0.000 0.000 1.000
D64 Other anaemias
1.000 0.000 0.000
K44 Diaphragmatic hernia
0.000 0.000 1.000
Chapter XI Diseases of the digestive system
0.103 0.000 0.896
Chapter XIV Diseases of the genitourinary system
0.000 0.000 1.000
M35 Other systemic involvement of connective tissue
1.000 0.000 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.999 0.001 0.000
M35.0 Sicca syndrome [Sjogren]
0.999 0.001 0.000
E83.1 Disorders of iron metabolism
0.000 0.001 0.999
N39 Other disorders of urinary system
0.000 0.001 0.999
Chapter VII Diseases of the eye and adnexa
0.999 0.001 0.000
E16 Other disorders of pancreatic internal secretion
0.999 0.001 0.000
E16.2 Hypoglycaemia, unspecified
0.999 0.001 0.000
K90-K93 Other diseases of the digestive system
0.104 0.004 0.892
N80-N98 Noninflammatory disorders of female genital tract
0.000 0.004 0.996
D80-D89 Certain disorders involving the immune mechanism
0.995 0.005 0.000
N81 Female genital prolapse
0.000 0.005 0.995
M05-M14 Inflammatory polyarthropathies
0.992 0.008 0.000
N42 Other disorders of prostate
0.000 0.008 0.992
N81.2 Incomplete uterovaginal prolapse
0.000 0.008 0.992
E05.0 Thyrotoxicosis with diffuse goitre
0.991 0.009 0.000
M23 Internal derangement of knee
0.991 0.009 0.000
H30-H36 Disorders of choroid and retina
0.990 0.010 0.000
N87 Dysplasia of cervix uteri
0.000 0.011 0.989
D86 Sarcoidosis
0.988 0.012 0.000
N39.8 Other specified disorders of urinary system
0.000 0.013 0.987
M15-M19 Arthrosis
0.986 0.014 0.000
E20-E35 Disorders of other endocrine glands
0.986 0.014 0.000
N32 Other disorders of bladder
0.000 0.015 0.985
M17 Gonarthrosis [arthrosis of knee]
0.984 0.016 0.000
E27 Other disorders of adrenal gland
0.983 0.017 0.000
K51 Ulcerative colitis
0.000 0.017 0.983
K50-K52 Noninfective enteritis and colitis
0.023 0.018 0.959
M20.1 Hallux valgus (acquired)
0.000 0.018 0.982
E11 Non-insulin-dependent diabetes mellitus
0.981 0.019 0.000
E27.1 Primary adrenocortical insufficiency
0.981 0.019 0.000
N32.0 Bladder-neck obstruction
0.000 0.019 0.981
D86.9 Sarcoidosis, unspecified
0.978 0.022 0.000
M20 Acquired deformities of fingers and toes
0.000 0.023 0.977
K51.2 Ulcerative (chronic) proctitis
0.000 0.023 0.977
E10.3 With ophthalmic complications
0.975 0.025 0.000
K51.9 Ulcerative colitis, unspecified
0.000 0.026 0.974
M17.9 Gonarthrosis, unspecified
0.973 0.027 0.000
E14 Unspecified diabetes mellitus
0.971 0.029 0.000
M20.5 Other deformities of toe(s) (acquired)
0.000 0.030 0.970
N39.0 Urinary tract infection, site not specified
0.000 0.032 0.968
M34 Systemic sclerosis
0.967 0.033 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.000 0.034 0.965
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.035 0.965
I70-I79 Diseases of arteries, arterioles and capillaries
0.964 0.036 0.000
T39.1 4-Aminophenol derivatives
0.000 0.037 0.963
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.039 0.961
I73 Other peripheral vascular diseases
0.960 0.040 0.000
N81.4 Uterovaginal prolapse, unspecified
0.000 0.041 0.959
H43-H45 Disorders of vitreous body and globe
0.959 0.041 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.959 0.041 0.000
T42.4 Benzodiazepines
0.000 0.043 0.957
K40.2 Bilateral inguinal hernia, without obstruction or gangrene
0.000 0.044 0.956
N87.9 Dysplasia of cervix uteri, unspecified
0.000 0.045 0.955
Chapter IX Diseases of the circulatory system
0.954 0.046 0.000
I73.9 Peripheral vascular disease, unspecified
0.952 0.048 0.000
M60-M63 Disorders of muscles
0.950 0.050 0.000
M20.4 Other hammer toe(s) (acquired)
0.000 0.053 0.947
N39.3 Stress incontinence
0.000 0.054 0.946
H36 Retinal disorders in diseases classified elsewhere
0.945 0.055 0.000
H25-H28 Disorders of lens
0.945 0.055 0.000
M65-M68 Disorders of synovium and tendon
0.944 0.056 0.000
N42.8 Other specified disorders of prostate
0.000 0.057 0.943
E11.9 Without complications
0.942 0.058 0.000
E10.2 With renal complications
0.940 0.060 0.000
M17.1 Other primary gonarthrosis
0.940 0.060 0.000
E10.1 With ketoacidosis
0.939 0.061 0.000
N97 Female infertility
0.000 0.061 0.939
E11.5 With peripheral circulatory complications
0.934 0.066 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.000 0.066 0.934
N85 Other noninflammatory disorders of uterus, except cervix
0.000 0.067 0.933
K50 Crohn's disease [regional enteritis]
0.001 0.068 0.931
H46-H48 Disorders of optic nerve and visual pathways
0.930 0.070 0.000
M22 Disorders of patella
0.930 0.070 0.000
H43 Disorders of vitreous body
0.929 0.071 0.000
L20-L30 Dermatitis and eczema
0.928 0.072 0.000
M31 Other necrotising vasculopathies
0.927 0.073 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.927 0.073 0.000
H34 Retinal vascular occlusions
0.926 0.074 0.000
N87.0 Mild cervical dysplasia
0.000 0.076 0.924
M06 Other rheumatoid arthritis
0.924 0.076 0.000
N42.1 Congestion and haemorrhage of prostate
0.000 0.076 0.924
M23.3 Other meniscus derangements
0.922 0.078 0.000
E14.3 With ophthalmic complications
0.920 0.080 0.000
M67 Other disorders of synovium and tendon
0.919 0.081 0.000
H26 Other cataract
0.918 0.082 0.000
R30-R39 Symptoms and signs involving the urinary system
0.000 0.082 0.918
K90 Intestinal malabsorption
0.865 0.083 0.052
M23.2 Derangement of meniscus due to old tear or injury
0.915 0.085 0.000
H36.0 Diabetic retinopathy
0.913 0.087 0.000
K92 Other diseases of digestive system
0.002 0.088 0.910
M70-M79 Other soft tissue disorders
0.912 0.088 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.089 0.911
M62 Other disorders of muscle
0.911 0.089 0.000
H26.9 Cataract, unspecified
0.910 0.090 0.000
L50-L54 Urticaria and erythema
0.908 0.092 0.000
M24 Other specific joint derangements
0.904 0.096 0.000
H43.1 Vitreous haemorrhage
0.904 0.096 0.000
I77 Other disorders of arteries and arterioles
0.902 0.098 0.000
M06.9 Rheumatoid arthritis, unspecified
0.901 0.099 0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere
0.900 0.100 0.000
M72 Fibroblastic disorders
0.898 0.102 0.000
M67.8 Other specified disorders of synovium and tendon
0.897 0.103 0.000
N84 Polyp of female genital tract
0.000 0.104 0.896
L30 Other dermatitis
0.893 0.107 0.000
N85.2 Hypertrophy of uterus
0.000 0.107 0.893
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.107 0.893
N39.9 Disorder of urinary system, unspecified
0.000 0.108 0.892
K92.0 Haematemesis
0.000 0.109 0.890
M72.0 Palmar fascial fibromatosis [Dupuytren]
0.888 0.112 0.000
T39.0 Salicylates
0.000 0.114 0.886
N34 Urethritis and urethral syndrome
0.000 0.116 0.884
E27.4 Other and unspecified adrenocortical insufficiency
0.882 0.118 0.000
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand
0.882 0.118 0.000
M34.9 Systemic sclerosis, unspecified
0.880 0.120 0.000
M11 Other crystal arthropathies
0.878 0.122 0.000
R39 Other symptoms and signs involving the urinary system
0.000 0.125 0.875
K51.4 Pseudopolyposis of colon
0.000 0.125 0.875
M07 Psoriatic and enteropathic arthropathies
0.873 0.127 0.000
N84.1 Polyp of cervix uteri
0.000 0.127 0.873
N97.9 Female infertility, unspecified
0.000 0.130 0.870
M62.8 Other specified disorders of muscle
0.868 0.132 0.000
R39.8 Other and unspecified symptoms and signs involving the urinary system
0.000 0.132 0.868
D50-D53 Nutritional anaemias
0.868 0.132 0.000
K92.1 Melaena
0.000 0.133 0.867
M31.6 Other giant cell arteritis
0.865 0.135 0.000
N36 Other disorders of urethra
0.000 0.135 0.865
N41 Inflammatory diseases of prostate
0.000 0.137 0.863
E11.3 With ophthalmic complications
0.862 0.138 0.000
M34.1 CR(E)ST syndrome
0.862 0.138 0.000
L30.9 Dermatitis, unspecified
0.859 0.141 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.859 0.141 0.000
N87.1 Moderate cervical dysplasia
0.000 0.144 0.856
H34.8 Other retinal vascular occlusions
0.855 0.145 0.000
M10 Gout
0.853 0.147 0.000
E10.4 With neurological complications
0.852 0.148 0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)
0.848 0.152 0.000
E14.9 Without complications
0.848 0.152 0.000
N85.0 Endometrial glandular hyperplasia
0.000 0.152 0.848
M23.9 Internal derangement of knee, unspecified
0.847 0.153 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.847 0.153 0.000
I73.0 Raynaud's syndrome
0.846 0.154 0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.843 0.157 0.000
H35 Other retinal disorders
0.843 0.157 0.000
N81.9 Female genital prolapse, unspecified
0.000 0.158 0.842
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.838 0.162 0.000
R33 Retention of urine
0.000 0.162 0.838
K92.2 Gastro-intestinal haemorrhage, unspecified
0.000 0.164 0.836
I77.6 Arteritis, unspecified
0.835 0.165 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.165 0.835
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.000 0.168 0.832
M86-M90 Other osteopathies
0.832 0.168 0.000
E10.5 With peripheral circulatory complications
0.831 0.169 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.830 0.170 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.826 0.174 0.000
L10-L14 Bullous disorders
0.825 0.175 0.000
M22.3 Other derangements of patella
0.825 0.175 0.000
K51.3 Ulcerative (chronic) rectosigmoiditis
0.000 0.176 0.824
E70-E90 Metabolic disorders
0.824 0.176 0.000
D55-D59 Haemolytic anaemias
0.823 0.177 0.000
L27 Dermatitis due to substances taken internally
0.823 0.177 0.000
E50-E64 Other nutritional deficiencies
0.823 0.177 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.820 0.180 0.000
I74 Arterial embolism and thrombosis
0.820 0.180 0.000
M25 Other joint disorders, not elsewhere classified
0.820 0.180 0.000
K50.0 Crohn's disease of small intestine
0.000 0.181 0.819
K50.8 Other Crohn's disease
0.000 0.181 0.818
L52 Erythema nodosum
0.819 0.181 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.817 0.183 0.000
D61 Other aplastic anaemias
0.814 0.186 0.000
H35.8 Other specified retinal disorders
0.812 0.188 0.000
N42.9 Disorder of prostate, unspecified
0.000 0.191 0.809
L40-L45 Papulosquamous disorders
0.809 0.191 0.000
D83 Common variable immunodeficiency
0.806 0.194 0.000
M62.86 Other specified disorders of muscle (Lower leg)
0.804 0.196 0.000
N34.2 Other urethritis
0.000 0.196 0.804
L50 Urticaria
0.803 0.197 0.000
E10.8 With unspecified complications
0.802 0.198 0.000
K50.1 Crohn's disease of large intestine
0.000 0.198 0.802
D50 Iron deficiency anaemia
0.802 0.198 0.000
M15 Polyarthrosis
0.801 0.199 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.800 0.200 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.000 0.200 0.800
I70 Atherosclerosis
0.799 0.201 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.797 0.203 0.000
M11.2 Other chondrocalcinosis
0.797 0.203 0.000
M18 Arthrosis of first carpometacarpal joint
0.796 0.204 0.000
N20-N23 Urolithiasis
0.000 0.207 0.793
D86.0 Sarcoidosis of lung
0.792 0.208 0.000
H34.2 Other retinal artery occlusions
0.791 0.209 0.000
H27 Other disorders of lens
0.790 0.210 0.000
D86.8 Sarcoidosis of other and combined sites
0.789 0.211 0.000
E16.1 Other hypoglycaemia
0.789 0.211 0.000
M07.3 Other psoriatic arthropathies
0.789 0.211 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.787 0.213 0.000
N81.3 Complete uterovaginal prolapse
0.000 0.214 0.786
E13 Other specified diabetes mellitus
0.785 0.215 0.000
E20 Hypoparathyroidism
0.784 0.216 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.781 0.219 0.000
R35 Polyuria
0.000 0.219 0.781
K20-K31 Diseases of oesophagus, stomach and duodenum
0.000 0.219 0.781
N97.1 Female infertility of tubal origin
0.000 0.219 0.781
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.000 0.219 0.781
K92.9 Disease of digestive system, unspecified
0.001 0.220 0.779
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.779 0.221 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.775 0.225 0.000
I77.1 Stricture of artery
0.775 0.225 0.000
N36.2 Urethral caruncle
0.000 0.226 0.774
M23.6 Other spontaneous disruption of ligament(s) of knee
0.774 0.226 0.000
M34.8 Other forms of systemic sclerosis
0.773 0.227 0.000
N46 Male infertility
0.000 0.229 0.771
H26.1 Traumatic cataract
0.770 0.230 0.000
Chapter II Neoplasms
0.770 0.230 0.000
M76 Enthesopathies of lower limb, excluding foot
0.770 0.230 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.000 0.231 0.769
E10.0 With coma
0.768 0.232 0.000
K90.9 Intestinal malabsorption, unspecified
0.748 0.232 0.019
H26.4 After-cataract
0.767 0.233 0.000
D80 Immunodeficiency with predominantly antibody defects
0.767 0.233 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.766 0.234 0.000
H31 Other disorders of choroid
0.766 0.234 0.000
D86.3 Sarcoidosis of skin
0.765 0.235 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.765 0.235 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.764 0.236 0.000
N41.0 Acute prostatitis
0.000 0.236 0.764
M86 Osteomyelitis
0.763 0.237 0.000
E11.6 With other specified complications
0.762 0.238 0.000
M23.1 Discoid meniscus (congenital)
0.761 0.239 0.000
M14 Arthropathies in other diseases classified elsewhere
0.760 0.240 0.000
K51.8 Other ulcerative colitis
0.000 0.240 0.760
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.760 0.240 0.000
M35.7 Hypermobility syndrome
0.759 0.241 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.759 0.241 0.000
M25.9 Joint disorder, unspecified
0.759 0.241 0.000
N91 Absent, scanty and rare menstruation
0.000 0.242 0.758
M00-M03 Infectious arthropathies
0.757 0.243 0.000
M10.0 Idiopathic gout
0.757 0.243 0.000
D84 Other immunodeficiencies
0.755 0.245 0.000
K21 Gastro-oesophageal reflux disease
0.000 0.246 0.754
K46 Unspecified abdominal hernia
0.000 0.247 0.753
E23 Hypofunction and other disorders of pituitary gland
0.753 0.247 0.000
N30 Cystitis
0.000 0.247 0.753
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.725 0.250 0.025
L43 Lichen planus
0.750 0.250 0.000
N42.2 Atrophy of prostate
0.000 0.250 0.750
H46 Optic neuritis
0.750 0.250 0.000
K20 Oesophagitis
0.000 0.251 0.749
N32.8 Other specified disorders of bladder
0.000 0.253 0.747
E11.0 With coma
0.746 0.253 0.000
N20 Calculus of kidney and ureter
0.000 0.254 0.746
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.746 0.254 0.000
M12 Other specific arthropathies
0.745 0.255 0.000
N42.0 Calculus of prostate
0.000 0.255 0.745
Q38-Q45 Other congenital malformations of the digestive system
0.744 0.256 0.000
M22.8 Other disorders of patella
0.744 0.256 0.000
M23.99 Internal derangement of knee, unspecified (Unspecified ligament or Unspecified meniscus)
0.744 0.256 0.000
M62.6 Muscle strain
0.744 0.256 0.000
N32.3 Diverticulum of bladder
0.000 0.257 0.743
K22 Other diseases of oesophagus
0.000 0.258 0.742
N81.6 Rectocele
0.000 0.258 0.742
N85.6 Intra-uterine synechiae
0.000 0.260 0.740
M32 Systemic lupus erythematosus
0.739 0.261 0.000
H47.2 Optic atrophy
0.739 0.261 0.000
H30 Chorioretinal inflammation
0.739 0.261 0.000
M35.3 Polymyalgia rheumatica
0.739 0.261 0.000
M11.26 Other chondrocalcinosis (Lower leg)
0.738 0.262 0.000
M23.0 Cystic meniscus
0.737 0.263 0.000
Chapter XX External causes of morbidity and mortality
0.735 0.265 0.000
H53-H54 Visual disturbances and blindness
0.734 0.266 0.000
E07 Other disorders of thyroid
0.734 0.266 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.734 0.266 0.000
E10.6 With other specified complications
0.734 0.266 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.732 0.268 0.000
N20.0 Calculus of kidney
0.000 0.269 0.731
M24.1 Other articular cartilage disorders
0.730 0.270 0.000
H43.2 Crystalline deposits in vitreous body
0.730 0.270 0.000
M17.0 Primary gonarthrosis, bilateral
0.729 0.271 0.000
E27.2 Addisonian crisis
0.729 0.271 0.000
K44.0 Diaphragmatic hernia with obstruction, without gangrene
0.000 0.271 0.728
M67.4 Ganglion
0.728 0.271 0.000
M22.2 Patellofemoral disorders
0.728 0.272 0.000
I78 Diseases of capillaries
0.728 0.272 0.000
D50.9 Iron deficiency anaemia, unspecified
0.727 0.273 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.727 0.273 0.000
K40.0 Bilateral inguinal hernia, with obstruction, without gangrene
0.000 0.273 0.726
D62 Acute posthaemorrhagic anaemia
0.726 0.274 0.000
M23.8 Other internal derangements of knee
0.726 0.274 0.000
H43.8 Other disorders of vitreous body
0.726 0.274 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.726 0.274 0.000
E24 Cushing's syndrome
0.725 0.275 0.000
M23.4 Loose body in knee
0.725 0.275 0.000
L23 Allergic contact dermatitis
0.725 0.275 0.000
E06 Thyroiditis
0.723 0.277 0.000
H47.3 Other disorders of optic disk
0.722 0.278 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.722 0.278 0.000
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)
0.721 0.279 0.000
K21.9 Gastro-oesophageal reflux disease without oesophagitis
0.000 0.279 0.721
E14.1 With ketoacidosis
0.720 0.280 0.000
E29 Testicular dysfunction
0.720 0.280 0.000
L28 Lichen simplex chronicus and prurigo
0.718 0.282 0.000
E03.8 Other specified hypothyroidism
0.718 0.282 0.000
N36.3 Prolapsed urethral mucosa
0.000 0.282 0.718
D50.8 Other iron deficiency anaemias
0.718 0.282 0.000
C43 Malignant melanoma of skin
0.717 0.283 0.000
K22.1 Ulcer of oesophagus
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E10.7 With multiple complications
0.717 0.283 0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
E03.5 Myxoedema coma
0.717 0.283 0.000
E03.4 Atrophy of thyroid (acquired)
0.717 0.283 0.000
E03.3 Postinfectious hypothyroidism
0.717 0.283 0.000
E03.1 Congenital hypothyroidism without goitre
0.717 0.283 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.717 0.283 0.000
K40.4 Unilateral or unspecified inguinal hernia, with gangrene
0.000 0.283 0.717
K40.1 Bilateral inguinal hernia, with gangrene
0.000 0.283 0.717
N51 Disorders of male genital organs in diseases classified elsewhere
0.000 0.283 0.717
N44 Torsion of testis
0.000 0.283 0.717
N84.9 Polyp of female genital tract, unspecified
0.000 0.283 0.717
N37 Urethral disorders in diseases classified elsewhere
0.000 0.283 0.717
N33 Bladder disorders in diseases classified elsewhere
0.000 0.283 0.717
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.717 0.283 0.000
D64.4 Congenital dyserythropoietic anaemia
0.717 0.283 0.000
D64.3 Other sideroblastic anaemias
0.717 0.283 0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins
0.717 0.283 0.000
D64.1 Secondary sideroblastic anaemia due to disease
0.717 0.283 0.000
D64.0 Hereditary sideroblastic anaemia
0.717 0.283 0.000
K44.1 Diaphragmatic hernia with gangrene
0.000 0.283 0.717
M35.9 Systemic involvement of connective tissue, unspecified
0.717 0.283 0.000
M35.8 Other specified systemic involvement of connective tissue
0.717 0.283 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.717 0.283 0.000
M35.5 Multifocal fibrosclerosis
0.717 0.283 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.717 0.283 0.000
M35.2 Behcet's disease
0.717 0.283 0.000
E15 Nondiabetic hypoglycaemic coma
0.716 0.283 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.717 0.283 0.000
N39.2 Orthostatic proteinuria, unspecified
0.000 0.283 0.716
E16.9 Disorder of pancreatic internal secretion, unspecified
0.716 0.284 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.716 0.284 0.000
E16.4 Abnormal secretion of gastrin
0.716 0.284 0.000
E16.3 Increased secretion of glucagon
0.716 0.284 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.715 0.285 0.000
T43.2 Other and unspecified antidepressants
0.000 0.285 0.715
M62.82 Other specified disorders of muscle (Upper arm)
0.715 0.285 0.000
E11.1 With ketoacidosis
0.714 0.286 0.000
K93 Disorders of other digestive organs in diseases classified elsewhere
0.075 0.286 0.639
D82 Immunodeficiency associated with other major defects
0.713 0.287 0.000
D81 Combined immunodeficiencies
0.713 0.287 0.000
M17.3 Other posttraumatic gonarthrosis
0.713 0.287 0.000
K50.9 Crohn's disease, unspecified
0.000 0.287 0.713
L30.8 Other specified dermatitis
0.712 0.288 0.000
T36 Poisoning by systemic antibiotics
0.000 0.289 0.711
M09 Juvenile arthritis in diseases classified elsewhere
0.711 0.289 0.000
M08 Juvenile arthritis
0.711 0.289 0.000
M13 Other arthritis
0.711 0.289 0.000
N42.3 Dysplasia of prostate
0.000 0.289 0.711
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.711 0.289 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.710 0.290 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.710 0.290 0.000
H43.9 Disorder of vitreous body, unspecified
0.709 0.291 0.000
M33 Dermatopolymyositis
0.709 0.291 0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.709 0.291 0.000
E78.6 Lipoprotein deficiency
0.709 0.291 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.708 0.292 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.707 0.293 0.000
E32 Diseases of thymus
0.707 0.293 0.000
E31 Polyglandular dysfunction
0.707 0.293 0.000
E30 Disorders of puberty, not elsewhere classified
0.707 0.293 0.000
E25 Adrenogenital disorders
0.707 0.293 0.000
N32.4 Rupture of bladder, nontraumatic
0.000 0.294 0.706
N32.2 Vesical fistula, not elsewhere classified
0.000 0.294 0.706
M17.4 Other secondary gonarthrosis, bilateral
0.705 0.294 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.705 0.294 0.000
E27.5 Adrenomedullary hyperfunction
0.705 0.295 0.000
E27.0 Other adrenocortical overactivity
0.705 0.295 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.000 0.295 0.705
K51.1 Ulcerative (chronic) ileocolitis
0.000 0.295 0.705
H02 Other disorders of eyelid
0.704 0.296 0.000
T42.1 Iminostilbenes
0.000 0.296 0.704
L13 Other bullous disorders
0.704 0.296 0.000
M25.7 Osteophyte
0.703 0.297 0.000
E11.7 With multiple complications
0.703 0.297 0.000
L50.0 Allergic urticaria
0.703 0.297 0.000
M60 Myositis
0.703 0.297 0.000
M62.81 Other specified disorders of muscle (Shoulder region)
0.703 0.297 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.703 0.297 0.000
E78.1 Pure hyperglyceridaemia
0.702 0.298 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.702 0.298 0.000
M30 Polyarteritis nodosa and related conditions
0.700 0.300 0.000
Q50-Q56 Congenital malformations of genital organs
0.699 0.301 0.000
H44 Disorders of globe
0.699 0.301 0.000
M24.2 Disorder of ligament
0.698 0.302 0.000
C02 Malignant neoplasm of other and unspecified parts of tongue
0.698 0.302 0.000
E14.8 With unspecified complications
0.696 0.304 0.000
E14.7 With multiple complications
0.696 0.304 0.000
E14.6 With other specified complications
0.696 0.304 0.000
E14.5 With peripheral circulatory complications
0.696 0.304 0.000
E14.4 With neurological complications
0.696 0.304 0.000
E14.2 Withrenal complications
0.696 0.304 0.000
E14.0 With coma
0.696 0.304 0.000
L43.9 Lichen planus, unspecified
0.696 0.304 0.000
O60-O75 Complications of labour and delivery
0.696 0.304 0.000
D59 Acquired haemolytic anaemia
0.695 0.305 0.000
M06.4 Inflammatory polyarthropathy
0.695 0.305 0.000
M86.9 Osteomyelitis, unspecified
0.694 0.306 0.000
M62.83 Other specified disorders of muscle (Forearm)
0.694 0.306 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.000 0.306 0.694
N32.1 Vesicointestinal fistula
0.000 0.307 0.693
M34.2 Systemic sclerosis induced by drugs and chemicals
0.693 0.307 0.000
M34.0 Progressive systemic sclerosis
0.693 0.307 0.000
I60-I69 Cerebrovascular diseases
0.693 0.307 0.000
E83 Disorders of mineral metabolism
0.613 0.307 0.079
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.000 0.308 0.692
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.000 0.308 0.692
T41 Poisoning by anaesthetics and therapeutic gases
0.000 0.308 0.692
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.000 0.308 0.692
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.000 0.308 0.692
T39.4 Antirheumatics, not elsewhere classified
0.000 0.308 0.692
T39.2 Pyrazolone derivatives
0.000 0.308 0.692
L27.0 Generalised skin eruption due to drugs and medicaments
0.691 0.309 0.000
D64.8 Other specified anaemias
0.690 0.310 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.000 0.311 0.689
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.000 0.311 0.689
T42.5 Mixed antiepileptics, not elsewhere classified
0.000 0.311 0.689
T42.3 Barbiturates
0.000 0.311 0.689
T42.2 Succinimides and oxazolidinediones
0.000 0.311 0.689
M10.07 Idiopathic gout (Ankle and foot)
0.689 0.311 0.000
M07.36 Other psoriatic arthropathies (Lower leg)
0.688 0.312 0.000
O73 Retained placenta and membranes, without haemorrhage
0.688 0.312 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.687 0.313 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.687 0.313 0.000
D86.1 Sarcoidosis of lymph nodes
0.687 0.313 0.000
E05.8 Other thyrotoxicosis
0.686 0.314 0.000
V20-V29 Motorcycle rider injured in transport accident
0.686 0.314 0.000
N41.9 Inflammatory disease of prostate, unspecified
0.000 0.315 0.685
I00-I02 Acute rheumatic fever
0.684 0.316 0.000
R30 Pain associated with micturition
0.000 0.316 0.684
M22.4 Chondromalacia patellae
0.684 0.316 0.000
I77.2 Rupture of artery
0.682 0.318 0.000
M22.0 Recurrent dislocation of patella
0.682 0.318 0.000
L27.1 Localised skin eruption due to drugs and medicaments
0.682 0.318 0.000
H02.5 Other disorders affecting eyelid function
0.682 0.318 0.000
K22.2 Oesophageal obstruction
0.000 0.319 0.681
O73.0 Retained placenta, without haemorrhage
0.681 0.319 0.000
M63 Disorders of muscle in diseases classified elsewhere
0.681 0.319 0.000
M61 Calcification and ossification of muscle
0.681 0.319 0.000
O62 Abnormalities of forces of labour
0.681 0.319 0.000
M62.80 Other specified disorders of muscle (Multiple sites)
0.681 0.319 0.000
D61.9 Aplastic anaemia, unspecified
0.681 0.319 0.000
C04 Malignant neoplasm of floor of mouth
0.680 0.320 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.679 0.321 0.000
H36.8 Other retinal disorders in diseases classified elsewhere
0.678 0.322 0.000
H28 Cataract and other disorders of lens in diseases classified elsewhere
0.677 0.323 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.677 0.323 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.677 0.323 0.000
I77.8 Other specified disorders of arteries and arterioles
0.677 0.323 0.000
H27.0 Aphakia
0.676 0.324 0.000
N48 Other disorders of penis
0.000 0.325 0.675
K40.3 Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
0.000 0.326 0.674
H47.0 Disorders of optic nerve, not elsewhere classified
0.674 0.326 0.000
N99-N99 Other disorders of the genitourinary system
0.000 0.326 0.674
N97.8 Female infertility of other origin
0.000 0.327 0.673
N97.4 Female infertility associated with male factors
0.000 0.327 0.673
N97.3 Female infertility of cervical origin
0.000 0.327 0.673
N97.2 Female infertility of uterine origin
0.000 0.327 0.673

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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