TreeWAS – Variant ID: rs13245023

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
M25.5 Pain in joint	0.156	0.844
M25.50 Pain in joint (Multiple sites)	0.153	0.847
M25 Other joint disorders, not elsewhere classified	0.147	0.853
M20-M25 Other joint disorders	0.145	0.855
M25.51 Pain in joint (Shoulder region)	0.139	0.861
M24 Other specific joint derangements	0.134	0.866
M23 Internal derangement of knee	0.132	0.868
M25.54 Pain in joint (Hand)	0.132	0.868
M25.55 Pain in joint (Pelvic region and thigh)	0.126	0.874
M25.57 Pain in joint (Ankle and foot)	0.126	0.874
M25.59 Pain in joint (Site unspecified)	0.125	0.875
M25.58 Pain in joint (Other)	0.123	0.877
M25.3 Other instability of joint	0.122	0.878
M34 Systemic sclerosis	0.121	0.879
M31 Other necrotising vasculopathies	0.121	0.879
M22 Disorders of patella	0.120	0.880
M23.8 Other internal derangements of knee	0.118	0.882
M23.3 Other meniscus derangements	0.118	0.882
M24.0 Loose body in joint	0.113	0.886
M24.4 Recurrent dislocation and subluxation of joint	0.113	0.887
M21 Other acquired deformities of limbs	0.113	0.887
M35 Other systemic involvement of connective tissue	0.111	0.889
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)	0.106	0.894
M25.2 Flail joint	0.106	0.894
M25.1 Fistula of joint	0.106	0.894
M25.0 Haemarthrosis	0.106	0.894
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.105	0.895
M23.9 Internal derangement of knee, unspecified	0.105	0.895
M24.2 Disorder of ligament	0.104	0.896
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.104	0.896
M33 Dermatopolymyositis	0.104	0.896
M32 Systemic lupus erythematosus	0.104	0.896
M30 Polyarteritis nodosa and related conditions	0.104	0.896
M25.9 Joint disorder, unspecified	0.104	0.896
M23.6 Other spontaneous disruption of ligament(s) of knee	0.102	0.898
M25.56 Pain in joint (Lower leg)	0.102	0.898
M23.0 Cystic meniscus	0.101	0.899
M24.8 Other specific joint derangements, not elsewhere classified	0.099	0.901
M24.02 Loose body in joint (Upper arm)	0.099	0.901
M24.41 Recurrent dislocation and subluxation of joint (Shoulder region)	0.098	0.902
M25.6 Stiffness of joint, not elsewhere classified	0.098	0.902
M31.3 Wegener's granulomatosis	0.098	0.902
M25.52 Pain in joint (Upper arm)	0.097	0.902
M34.1 CR(E)ST syndrome	0.097	0.903
M25.36 Other instability of joint (Lower leg)	0.097	0.903
M34.9 Systemic sclerosis, unspecified	0.097	0.903
M25.37 Other instability of joint (Ankle and foot)	0.097	0.903
M25.53 Pain in joint (Forearm)	0.096	0.904
M25.7 Osteophyte	0.096	0.904
M35.3 Polymyalgia rheumatica	0.096	0.904
M24.9 Joint derangement, unspecified	0.096	0.904
M24.7 Protrusio acetabuli	0.096	0.904
M24.6 Ankylosis of joint	0.096	0.904
M24.5 Contracture of joint	0.096	0.904
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.096	0.904
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.096	0.904
M23.4 Loose body in knee	0.095	0.904
M22.2 Patellofemoral disorders	0.095	0.904
M23.1 Discoid meniscus (congenital)	0.095	0.905
M24.1 Other articular cartilage disorders	0.095	0.905
M25.8 Other specified joint disorders	0.093	0.907
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.093	0.907
M21.2 Flexion deformity	0.092	0.908
M25.4 Effusion of joint	0.091	0.908
M23.5 Chronic instability of knee	0.091	0.909
M22.3 Other derangements of patella	0.091	0.909
M22.4 Chondromalacia patellae	0.091	0.909
M23.80 Other internal derangements of knee (Multiple sites)	0.090	0.910
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.089	0.911
M25.39 Other instability of joint (Site unspecified)	0.088	0.912
M25.38 Other instability of joint (Other)	0.088	0.912
M25.35 Other instability of joint (Pelvic region and thigh)	0.088	0.912
M25.34 Other instability of joint (Hand)	0.088	0.912
M25.33 Other instability of joint (Forearm)	0.088	0.912
M25.32 Other instability of joint (Upper arm)	0.088	0.912
M25.31 Other instability of joint (Shoulder region)	0.088	0.912
M25.30 Other instability of joint (Multiple sites)	0.088	0.912
M23.30 Other meniscus derangements (Multiple sites)	0.087	0.913
M34.8 Other forms of systemic sclerosis	0.087	0.913
M34.2 Systemic sclerosis induced by drugs and chemicals	0.087	0.913
M34.0 Progressive systemic sclerosis	0.087	0.913
M22.8 Other disorders of patella	0.087	0.913
M31.9 Necrotising vasculopathy, unspecified	0.087	0.913
M31.8 Other specified necrotising vasculopathies	0.087	0.913
M31.7 Microscopic polyangiitis	0.087	0.913
M31.4 Aortic arch syndrome [Takayasu]	0.087	0.913
M31.2 Lethal midline granuloma	0.087	0.913
M31.1 Thrombotic microangiopathy	0.087	0.913
M31.0 Hypersensitivity angiitis	0.087	0.913
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.086	0.914
M22.1 Recurrent subluxation of patella	0.086	0.914
M22.9 Disorder of patella, unspecified	0.086	0.914
M22.0 Recurrent dislocation of patella	0.086	0.914
M21.6 Other acquired deformities of ankle and foot	0.086	0.914
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.086	0.914
M35.7 Hypermobility syndrome	0.086	0.914
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.085	0.915
M23.99 Internal derangement of knee, unspecified (Unspecified ligament or Unspecified meniscus)	0.085	0.915
M23.87 Other internal derangements of knee (Capsular ligament)	0.085	0.915
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.085	0.915
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.085	0.915
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.085	0.915
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.085	0.915
M31.6 Other giant cell arteritis	0.085	0.915
M23.37 Other meniscus derangements-Capsular lig	0.084	0.915
M21.4 Flat foot [pes planus] (acquired)	0.084	0.916
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)	0.084	0.916
M23.81 Other internal derangements of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.083	0.916
M25.76 Osteophyte (Lower leg)	0.083	0.917
M24.24 Disorder of ligament (Hand)	0.082	0.918
M24.09 Loose body in joint (Site unspecified)	0.081	0.918
M24.08 Loose body in joint (Other)	0.081	0.918
M24.07 Loose body in joint (Ankle and foot)	0.081	0.918
M24.06 Loose body in joint-Lower leg	0.081	0.918
M24.05 Loose body in joint (Pelvic region and thigh)	0.081	0.918
M24.04 Loose body in joint (Hand)	0.081	0.918
M24.03 Loose body in joint (Forearm)	0.081	0.918
M24.01 Loose body in joint (Shoulder region)	0.081	0.918
M24.00 Loose body in joint (Multiple sites)	0.081	0.918
M24.49 Recurrent dislocation and subluxation of joint (Site unspecified)	0.081	0.919
M24.48 Recurrent dislocation and subluxation of joint (Other)	0.081	0.919
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)	0.081	0.919
M24.46 Recurrent dislocation and subluxation of joint (Lower leg)	0.081	0.919
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.081	0.919
M24.44 Recurrent dislocation and subluxation of joint (Hand)	0.081	0.919
M24.43 Recurrent dislocation and subluxation of joint (Forearm)	0.081	0.919
M24.42 Recurrent dislocation and subluxation of joint (Upper arm)	0.081	0.919
M24.40 Recurrent dislocation and subluxation of joint (Multiple sites)	0.081	0.919
M21.0 Valgus deformity, not elsewhere classified	0.081	0.919
M21.9 Acquired deformity of limb, unspecified	0.081	0.919
M21.8 Other specified acquired deformities of limbs	0.081	0.919
M21.7 Unequal limb length (acquired)	0.081	0.919
M23.61 Other spontaneous disruption of ligament(s) of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.080	0.920
M35.9 Systemic involvement of connective tissue, unspecified	0.080	0.920
M35.8 Other specified systemic involvement of connective tissue	0.080	0.920
M35.6 Relapsing panniculitis [Weber-Christian]	0.080	0.920
M35.5 Multifocal fibrosclerosis	0.080	0.920
M35.4 Diffuse (eosinophilic) fasciitis	0.080	0.920
M35.2 Behcet's disease	0.080	0.920
M35.1 Other overlap syndromes	0.080	0.920
M25.77 Osteophyte (Ankle and foot)	0.079	0.921
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)	0.079	0.921
M21.1 Varus deformity, not elsewhere classified	0.078	0.922
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.077	0.923
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.077	0.923
M24.23 Disorder of ligament (Forearm)	0.077	0.923
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.077	0.923
M25.09 Haemarthrosis (Site unspecified)	0.076	0.924
M25.08 Haemarthrosis (Other)	0.076	0.924
M25.07 Haemarthrosis (Ankle and foot)	0.076	0.924
M25.06 Haemarthrosis (Lower leg)	0.076	0.924
M25.05 Haemarthrosis (Pelvic region and thigh)	0.076	0.924
M25.04 Haemarthrosis (Hand)	0.076	0.924
M25.03 Haemarthrosis (Forearm)	0.076	0.924
M25.02 Haemarthrosis (Upper arm)	0.076	0.924
M25.01 Haemarthrosis (Shoulder region)	0.076	0.924
M25.00 Haemarthrosis (Multiple sites)	0.076	0.924
M25.19 Fistula of joint (Site unspecified)	0.076	0.924
M25.18 Fistula of joint (Other)	0.076	0.924
M25.17 Fistula of joint (Ankle and foot)	0.076	0.924
M25.16 Fistula of joint (Lower leg)	0.076	0.924
M25.15 Fistula of joint (Pelvic region and thigh)	0.076	0.924
M25.14 Fistula of joint (Hand)	0.076	0.924
M25.13 Fistula of joint (Forearm)	0.076	0.924
M25.12 Fistula of joint (Upper arm)	0.076	0.924
M25.11 Fistula of joint (Shoulder region)	0.076	0.924
M25.10 Fistula of joint (Multiple sites)	0.076	0.924
M25.29 Flail joint (Site unspecified)	0.076	0.924
M25.28 Flail joint (Other)	0.076	0.924
M25.27 Flail joint (Ankle and foot)	0.076	0.924
M25.26 Flail joint (Lower leg)	0.076	0.924
M25.25 Flail joint (Pelvic region and thigh)	0.076	0.924
M25.24 Flail joint (Hand)	0.076	0.924
M25.23 Flail joint (Forearm)	0.076	0.924
M25.22 Flail joint (Upper arm)	0.076	0.924
M25.21 Flail joint (Shoulder region)	0.076	0.924
M25.20 Flail joint (Multiple sites)	0.076	0.924
M23.97 Internal derangement of knee, unspecified (Capsular ligament)	0.075	0.924
M23.96 Internal derangement of knee, unspecified (Other and unspecified lateral meniscus)	0.075	0.924
M23.95 Internal derangement of knee, unspecified (Posterior horn of lateral meniscus)	0.075	0.924
M23.94 Internal derangement of knee, unspecified (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.075	0.924
M23.93 Internal derangement of knee, unspecified (Medial collateral ligament or Other and unspecified medial meniscus)	0.075	0.924
M23.92 Internal derangement of knee, unspecified (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.075	0.924
M23.91 Internal derangement of knee, unspecified (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.075	0.924
M23.90 Internal derangement of knee, unspecified (Multiple sites)	0.075	0.924
M24.29 Disorder of ligament (Site unspecified)	0.075	0.925
M24.28 Disorder of ligament (Other)	0.075	0.925
M24.27 Disorder of ligament (Ankle and foot)	0.075	0.925
M24.26 Disorder of ligament (Lower leg)	0.075	0.925
M24.25 Disorder of ligament (Pelvic region and thigh)	0.075	0.925
M24.22 Disorder of ligament (Upper arm)	0.075	0.925
M24.21 Disorder of ligament (Shoulder region)	0.075	0.925
M24.20 Disorder of ligament (Multiple sites)	0.075	0.925
M30.8 Other conditions related to polyarteritis nodosa	0.075	0.925
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.075	0.925
M30.2 Juvenile polyarteritis	0.075	0.925
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.075	0.925
M30.0 Polyarteritis nodosa	0.075	0.925
M32.9 Systemic lupus erythematosus, unspecified	0.075	0.925
M32.8 Other forms of systemic lupus erythematosus	0.075	0.925
M32.1 Systemic lupus erythematosus with organ or system involvement	0.075	0.925
M32.0 Drug-induced systemic lupus erythematosus	0.075	0.925
M33.9 Dermatopolymyositis, unspecified	0.075	0.925
M33.2 Polymyositis	0.075	0.925
M33.1 Other dermatomyositis	0.075	0.925
M33.0 Juvenile dermatomyositis	0.075	0.925
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.075	0.925
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.075	0.925
M36.3 Arthropathy in other blood disorders	0.075	0.925
M36.2 Haemophilic arthropathy	0.075	0.925
M36.1 Arthropathy in neoplastic disease	0.075	0.925
M36.0 Dermato(poly)myositis in neoplastic disease	0.075	0.925
M25.99 Joint disorder, unspecified (Site unspecified)	0.075	0.925
M25.98 Joint disorder, unspecified (Other)	0.075	0.925
M25.97 Joint disorder, unspecified (Ankle and foot)	0.075	0.925
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.075	0.925
M25.94 Joint disorder, unspecified (Hand)	0.075	0.925
M25.93 Joint disorder, unspecified (Forearm)	0.075	0.925
M25.92 Joint disorder, unspecified (Upper arm)	0.075	0.925
M25.91 Joint disorder, unspecified (Shoulder region)	0.075	0.925
M25.90 Joint disorder, unspecified (Multiple sites)	0.075	0.925
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.074	0.926
M24.11 Other articular cartilage disorders (Shoulder region)	0.074	0.926
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.073	0.926
M23.69 Other spontaneous disruption of ligament(s) of knee (Unspecified ligament or Unspecified meniscus)	0.073	0.927
M23.67 Other spontaneous disruption of ligament(s) of knee (Capsular ligament)	0.073	0.927
M23.66 Other spontaneous disruption of ligament(s) of knee-O/unsp	0.073	0.927
M23.65 Other spontaneous disruption of ligament(s) of knee-Pst hrn	0.073	0.927
M23.64 Other spontaneous disruption of ligament(s) of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.073	0.927
M23.63 Other spontaneous disruption of ligament(s) of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.073	0.927
M23.62 Other spontaneous disruption of ligament(s) of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.073	0.927
M23.60 Other spontaneous disruption of ligament(s) of knee (Multiple sites)	0.073	0.927
M23.09 Cystic meniscus (Unspecified ligament or Unspecified meniscus)	0.073	0.927
M23.07 Cystic meniscus-Capsular lig	0.073	0.927
M23.06 Cystic meniscus (Other and unspecified lateral meniscus)	0.073	0.927
M23.05 Cystic meniscus (Posterior horn of lateral meniscus)	0.073	0.927
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.073	0.927
M23.02 Cystic meniscus (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.073	0.927
M23.01 Cystic meniscus (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.073	0.927
M23.00 Cystic meniscus (Multiple sites)	0.073	0.927
M25.96 Joint disorder, unspecified (Lower leg)	0.073	0.927
M21.27 Flexion deformity (Ankle and foot)	0.073	0.927
M25.75 Osteophyte (Pelvic region and thigh)	0.072	0.928
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.071	0.928
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.071	0.928
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.071	0.928
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.071	0.928
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.071	0.928
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.071	0.928
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.071	0.928
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.071	0.928
M21.24 Flexion deformity (Hand)	0.071	0.929
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.070	0.929
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.070	0.929
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.070	0.929
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.070	0.929
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.070	0.929
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.070	0.929
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.070	0.929
M25.87 Other specified joint disorders (Ankle and foot)	0.070	0.929
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.069	0.931
M25.79 Osteophyte (Site unspecified)	0.069	0.931
M25.73 Osteophyte (Forearm)	0.069	0.931
M25.70 Osteophyte (Multiple sites)	0.069	0.931
M23.49 Loose body in knee-Unspec lig/men	0.069	0.931
M24.39 Pathological dislocation and subluxation of joint, not elsewhere classified (Site unspecified)	0.069	0.931
M24.38 Pathological dislocation and subluxation of joint, not elsewhere classified (Other)	0.069	0.931
M24.37 Pathological dislocation and subluxation of joint, not elsewhere classified (Ankle and foot)	0.069	0.931
M24.36 Pathological dislocation and subluxation of joint, not elsewhere classified (Lower leg)	0.069	0.931
M24.35 Pathological dislocation and subluxation of joint, not elsewhere classified (Pelvic region and thigh)	0.069	0.931
M24.34 Pathological dislocation and subluxation of joint, not elsewhere classified (Hand)	0.069	0.931
M24.33 Pathological dislocation and subluxation of joint, not elsewhere classified (Forearm)	0.069	0.931
M24.32 Pathological dislocation and subluxation of joint, not elsewhere classified (Upper arm)	0.069	0.931
M24.31 Pathological dislocation and subluxation of joint, not elsewhere classified (Shoulder region)	0.069	0.931
M24.30 Pathological dislocation and subluxation of joint, not elsewhere classified (Multiple sites)	0.069	0.931
M24.59 Contracture of joint (Site unspecified)	0.069	0.931
M24.58 Contracture of joint (Other)	0.069	0.931
M24.57 Contracture of joint (Ankle and foot)	0.069	0.931
M24.56 Contracture of joint (Lower leg)	0.069	0.931
M24.55 Contracture of joint (Pelvic region and thigh)	0.069	0.931
M24.54 Contracture of joint (Hand)	0.069	0.931
M24.53 Contracture of joint (Forearm)	0.069	0.931
M24.52 Contracture of joint (Upper arm)	0.069	0.931
M24.51 Contracture of joint (Shoulder region)	0.069	0.931
M24.50 Contracture of joint (Multiple sites)	0.069	0.931
M24.69 Ankylosis of joint (Site unspecified)	0.069	0.931
M24.68 Ankylosis of joint (Other)	0.069	0.931
M24.67 Ankylosis of joint (Ankle and foot)	0.069	0.931
M24.66 Ankylosis of joint (Lower leg)	0.069	0.931
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.069	0.931
M24.64 Ankylosis of joint (Hand)	0.069	0.931
M24.63 Ankylosis of joint (Forearm)	0.069	0.931
M24.62 Ankylosis of joint (Upper arm)	0.069	0.931
M24.61 Ankylosis of joint (Shoulder region)	0.069	0.931
M24.60 Ankylosis of joint (Multiple sites)	0.069	0.931
M24.79 Protrusio acetabuli-Site unspec	0.069	0.931
M24.78 Protrusio acetabuli-Other	0.069	0.931
M24.77 Protrusio acetabuli-Ankle/foot	0.069	0.931
M24.76 Protrusio acetabuli-Lower leg	0.069	0.931
M24.75 Protrusio acetabuli-Pelvic/thigh	0.069	0.931
M24.74 Protrusio acetabuli-Hand	0.069	0.931
M24.73 Protrusio acetabuli-Forearm	0.069	0.931
M24.72 Protrusio acetabuli-Upper arm	0.069	0.931
M24.71 Protrusio acetabuli-Shldr region	0.069	0.931
M24.70 Protrusio acetabuli-Mult sites	0.069	0.931
M24.99 Joint derangement, unspecified (Site unspecified)	0.069	0.931
M24.98 Joint derangement, unspecified (Other)	0.069	0.931
M24.97 Joint derangement, unspecified (Ankle and foot)	0.069	0.931
M24.96 Joint derangement, unspecified (Lower leg)	0.069	0.931
M24.95 Joint derangement, unspecified (Pelvic region and thigh)	0.069	0.931
M24.94 Joint derangement, unspecified (Hand)	0.069	0.931
M24.93 Joint derangement, unspecified (Forearm)	0.069	0.931
M24.92 Joint derangement, unspecified (Upper arm)	0.069	0.931
M24.91 Joint derangement, unspecified (Shoulder region)	0.069	0.931
M24.90 Joint derangement, unspecified (Multiple sites)	0.069	0.931
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.069	0.931
M23.47 Loose body in knee-Capsular lig	0.069	0.931
M23.46 Loose body in knee-O/unsp lat men	0.069	0.931
M23.45 Loose body in knee-Pst hrn lat men	0.069	0.931
M23.44 Loose body in knee-Lat lig/ant men	0.069	0.931
M23.43 Loose body in knee-Med lig/oth men	0.069	0.931
M23.42 Loose body in knee-Pst lig/hrn men	0.069	0.931
M23.41 Loose body in knee-Ant lig/hrn men	0.069	0.931
M23.40 Loose body in knee-Mult sites	0.069	0.931
M25.72 Osteophyte (Upper arm)	0.069	0.931
M23.19 Discoid meniscus (congenital) (Unspecified ligament or Unspecified meniscus)	0.068	0.932
M23.17 Discoid meniscus (congenital)-Capsular lig	0.068	0.932
M23.16 Discoid meniscus (congenital) (Other and unspecified lateral meniscus)	0.068	0.932
M23.15 Discoid meniscus (congenital) (Posterior horn of lateral meniscus)	0.068	0.932
M23.14 Discoid meniscus (congenital) (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.068	0.932
M23.13 Discoid meniscus (congenital) (Medial collateral ligament or Other and unspecified medial meniscus)	0.068	0.932
M23.12 Discoid meniscus (congenital) (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.068	0.932
M23.11 Discoid meniscus (congenital) (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.068	0.932
M23.10 Discoid meniscus (congenital) (Multiple sites)	0.068	0.932
M24.19 Other articular cartilage disorders (Site unspecified)	0.068	0.932
M24.18 Other articular cartilage disorders (Other)	0.068	0.932
M24.17 Other articular cartilage disorders (Ankle and foot)	0.068	0.932
M24.14 Other articular cartilage disorders (Hand)	0.068	0.932
M24.13 Other articular cartilage disorders (Forearm)	0.068	0.932
M24.12 Other articular cartilage disorders (Upper arm)	0.068	0.932
M24.10 Other articular cartilage disorders (Multiple sites)	0.068	0.932
M25.47 Effusion of joint (Ankle and foot)	0.068	0.932
M25.89 Other specified joint disorders (Site unspecified)	0.067	0.933
M25.88 Other specified joint disorders (Other)	0.067	0.933
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.067	0.933
M25.83 Other specified joint disorders (Forearm)	0.067	0.933
M25.82 Other specified joint disorders (Upper arm)	0.067	0.933
M25.81 Other specified joint disorders (Shoulder region)	0.067	0.933
M25.80 Other specified joint disorders (Multiple sites)	0.067	0.933
M21.67 Other acquired deformities of ankle and foot-Ankle/foot	0.067	0.933
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.066	0.933
M21.29 Flexion deformity (Site unspecified)	0.066	0.934
M21.28 Flexion deformity (Other)	0.066	0.934
M21.26 Flexion deformity (Lower leg)	0.066	0.934
M21.25 Flexion deformity (Pelvic region and thigh)	0.066	0.934
M21.23 Flexion deformity (Forearm)	0.066	0.934
M21.22 Flexion deformity (Upper arm)	0.066	0.934
M21.21 Flexion deformity (Shoulder region)	0.066	0.934
M21.20 Flexion deformity (Multiple sites)	0.066	0.934
M25.49 Effusion of joint (Site unspecified)	0.066	0.934
M25.48 Effusion of joint (Other)	0.066	0.934
M25.45 Effusion of joint (Pelvic region and thigh)	0.066	0.934
M25.44 Effusion of joint (Hand)	0.066	0.934
M25.43 Effusion of joint (Forearm)	0.066	0.934
M25.42 Effusion of joint (Upper arm)	0.066	0.934
M25.41 Effusion of joint (Shoulder region)	0.066	0.934
M25.40 Effusion of joint (Multiple sites)	0.066	0.934
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.066	0.934
M23.57 Chronic instability of knee (Capsular ligament)	0.066	0.934
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.066	0.934
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.066	0.934
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.066	0.934
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.066	0.934
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.066	0.934
M23.50 Chronic instability of knee (Multiple sites)	0.066	0.934
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.065	0.935
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.064	0.936
M21.3 Wrist or foot drop (acquired)	0.063	0.936
M22.10 Recurrent subluxation of patella, unspecified knee	0.062	0.938
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.062	0.938
M21.69 Other acquired deformities of ankle and foot-Site unspec	0.062	0.938
M21.68 Other acquired deformities of ankle and foot-Other	0.062	0.938
M21.66 Other acquired deformities of ankle and foot-Lower leg	0.062	0.938
M21.65 Other acquired deformities of ankle and foot-Pelvic/thigh	0.062	0.938
M21.64 Other acquired deformities of ankle and foot-Hand	0.062	0.938
M21.63 Other acquired deformities of ankle and foot-Forearm	0.062	0.938
M21.62 Other acquired deformities of ankle and foot-Upper arm	0.062	0.938
M21.61 Other acquired deformities of ankle and foot-Shldr region	0.062	0.938
M21.60 Other acquired deformities of ankle and foot-Mult sites	0.062	0.938
M21.59 Acquired clawhand, clubhand, clawfoot and clubfoot-Site uns	0.062	0.938
M21.58 Acquired clawhand, clubhand, clawfoot and clubfoot-Other	0.062	0.938
M21.56 Acquired clawhand, clubhand, clawfoot and clubfoot-Lower le	0.062	0.938
M21.55 Acquired clawhand, clubhand, clawfoot and clubfoot-Pelvic/t	0.062	0.938
M21.54 Acquired clawhand, clubhand, clawfoot and clubfoot (Hand)	0.062	0.938
M21.53 Acquired clawhand, clubhand, clawfoot and clubfoot-Forearm	0.062	0.938
M21.52 Acquired clawhand, clubhand, clawfoot and clubfoot-Upper ar	0.062	0.938
M21.51 Acquired clawhand, clubhand, clawfoot and clubfoot-Shldr re	0.062	0.938
M21.50 Acquired clawhand, clubhand, clawfoot and clubfoot (Multiple sites)	0.062	0.938
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.061	0.939
M21.49 Flat foot [pes planus] (acquired)-Site unspec	0.060	0.939
M21.48 Flat foot [pes planus] (acquired)-Other	0.060	0.939
M21.46 Flat foot [pes planus] (acquired)-Lower leg	0.060	0.939
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh	0.060	0.939
M21.44 Flat foot [pes planus] (acquired)-Hand	0.060	0.939
M21.43 Flat foot [pes planus] (acquired)-Forearm	0.060	0.939
M21.42 Flat foot [pes planus] (acquired)-Upper arm	0.060	0.939
M21.41 Flat foot [pes planus] (acquired)-Shldr region	0.060	0.939
M21.40 Flat foot [pes planus] (acquired)-Mult sites	0.060	0.939
M25.84 Other specified joint disorders (Hand)	0.060	0.940
M21.09 Valgus deformity, not elsewhere classified (Site unspecified)	0.058	0.942
M21.08 Valgus deformity, not elsewhere classified (Other)	0.058	0.942
M21.05 Valgus deformity, not elsewhere classified (Pelvic region and thigh)	0.058	0.942
M21.04 Valgus deformity, not elsewhere classified (Hand)	0.058	0.942
M21.03 Valgus deformity, not elsewhere classified (Forearm)	0.058	0.942
M21.02 Valgus deformity, not elsewhere classified (Upper arm)	0.058	0.942
M21.01 Valgus deformity, not elsewhere classified (Shoulder region)	0.058	0.942
M21.00 Valgus deformity, not elsewhere classified (Multiple sites)	0.058	0.942
M25.86 Other specified joint disorders (Lower leg)	0.058	0.942
M21.79 Unequal limb length (acquired) (Site unspecified)	0.058	0.942
M21.78 Unequal limb length (acquired)-Other	0.058	0.942
M21.77 Unequal limb length (acquired) (Ankle and foot)	0.058	0.942
M21.76 Unequal limb length (acquired) (Lower leg)	0.058	0.942
M21.75 Unequal limb length (acquired) (Pelvic region and thigh)	0.058	0.942
M21.74 Unequal limb length (acquired) (Hand)	0.058	0.942
M21.73 Unequal limb length (acquired) (Forearm)	0.058	0.942
M21.72 Unequal limb length (acquired) (Upper arm)	0.058	0.942
M21.71 Unequal limb length (acquired)-Shldr region	0.058	0.942
M21.70 Unequal limb length (acquired) (Multiple sites)	0.058	0.942
M21.89 Other specified acquired deformities of limbs (Site unspecified)	0.058	0.942
M21.88 Other specified acquired deformities of limbs-Other	0.058	0.942
M21.87 Other specified acquired deformities of limbs (Ankle and foot)	0.058	0.942
M21.86 Other specified acquired deformities of limbs (Lower leg)	0.058	0.942
M21.85 Other specified acquired deformities of limbs (Pelvic region and thigh)	0.058	0.942
M21.84 Other specified acquired deformities of limbs (Hand)	0.058	0.942
M21.83 Other specified acquired deformities of limbs (Forearm)	0.058	0.942
M21.82 Other specified acquired deformities of limbs (Upper arm)	0.058	0.942
M21.81 Other specified acquired deformities of limbs (Shoulder region)	0.058	0.942
M21.80 Other specified acquired deformities of limbs (Multiple sites)	0.058	0.942
M21.99 Acquired deformity of limb, unspecified (Site unspecified)	0.058	0.942
M21.98 Acquired deformity of limb, unspecified-Other	0.058	0.942
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.058	0.942
M21.96 Acquired deformity of limb, unspecified (Lower leg)	0.058	0.942
M21.95 Acquired deformity of limb, unspecified (Pelvic region and thigh)	0.058	0.942
M21.94 Acquired deformity of limb, unspecified (Hand)	0.058	0.942
M21.93 Acquired deformity of limb, unspecified (Forearm)	0.058	0.942
M21.92 Acquired deformity of limb, unspecified (Upper arm)	0.058	0.942
M21.91 Acquired deformity of limb, unspecified (Shoulder region)	0.058	0.942
M21.90 Acquired deformity of limb, unspecified (Multiple sites)	0.058	0.942
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified	0.057	0.942
M25.71 Osteophyte (Shoulder region)	0.056	0.944
M21.19 Varus deformity, not elsewhere classified (Site unspecified)	0.056	0.944
M21.18 Varus deformity, not elsewhere classified (Other)	0.056	0.944
M21.15 Varus deformity, not elsewhere classified (Pelvic region and thigh)	0.056	0.944
M21.14 Varus deformity, not elsewhere classified (Hand)	0.056	0.944
M21.13 Varus deformity, not elsewhere classified (Forearm)	0.056	0.944
M21.12 Varus deformity, not elsewhere classified (Upper arm)	0.056	0.944
M21.11 Varus deformity, not elsewhere classified (Shoulder region)	0.056	0.944
M21.10 Varus deformity, not elsewhere classified (Multiple sites)	0.056	0.944
M21.17 Varus deformity, not elsewhere classified (Ankle and foot)	0.055	0.945
M32.90 Systemic lupus erythematosus, unspecified, Multiple sites	0.054	0.946
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.054	0.946
M35.0 Sicca syndrome [Sjogren]	0.052	0.947
M25.74 Osteophyte (Hand)	0.051	0.949
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.050	0.950
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.048	0.951
M24.16 Other articular cartilage disorders (Lower leg)	0.048	0.952
M25.46 Effusion of joint (Lower leg)	0.048	0.952
M25.78 Osteophyte (Other)	0.047	0.952
M50-M54 Other dorsopathies	0.047	0.953
M21.39 Wrist or foot drop (acquired)-Site unspec	0.045	0.954
M21.38 Wrist or foot drop (acquired)-Other	0.045	0.954
M21.36 Wrist or foot drop (acquired)-Lower leg	0.045	0.954
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.045	0.954
M21.34 Wrist or foot drop (acquired) (Hand)	0.045	0.954
M21.33 Wrist or foot drop (acquired) (Forearm)	0.045	0.954
M21.32 Wrist or foot drop (acquired)-Upper arm	0.045	0.954
M21.31 Wrist or foot drop (acquired)-Shldr region	0.045	0.954
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.045	0.954
M65-M68 Disorders of synovium and tendon	0.044	0.956
M51 Other intervertebral disk disorders	0.041	0.959
M60-M63 Disorders of muscles	0.041	0.959
M54 Dorsalgia	0.040	0.960
M40-M43 Deforming dorsopathies	0.040	0.960
M91-M94 Chondropathies	0.040	0.960
M67 Other disorders of synovium and tendon	0.039	0.961
M53 Other dorsopathies, not elsewhere classified	0.038	0.962
M70-M79 Other soft tissue disorders	0.038	0.962
M51.8 Other specified intervertebral disk disorders	0.037	0.963
M67.8 Other specified disorders of synovium and tendon	0.036	0.964
M86-M90 Other osteopathies	0.036	0.964
M54.2 Cervicalgia	0.036	0.964
M00-M03 Infectious arthropathies	0.035	0.964
M20 Acquired deformities of fingers and toes	0.035	0.965
M70 Soft tissue disorders related to use, overuse and pressure	0.035	0.965
M41 Scoliosis	0.034	0.966
M66 Spontaneous rupture of synovium and tendon	0.033	0.967
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.033	0.967
M70.6 Trochanteric bursitis	0.033	0.967
M54.4 Lumbago with sciatica	0.033	0.967
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.032	0.968

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations