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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs138450362
log Bayes Factor = 1.99354
Chromosome 16   position 22,950,613  (GRCh37) Explore rs138450362 on Ensembl!
Variant rs138450362 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
0.987 0.013 0.000
# Top node
0.986 0.014 0.000
Chapter VII Diseases of the eye and adnexa
0.985 0.015 0.000
M20-M25 Other joint disorders
0.983 0.017 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.983 0.017 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.978 0.022 0.000
M23 Internal derangement of knee
0.970 0.030 0.000
M20 Acquired deformities of fingers and toes
0.963 0.037 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.937 0.063 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.934 0.066 0.000
M20.5 Other deformities of toe(s) (acquired)
0.932 0.068 0.000
Chapter VI Diseases of the nervous system
0.921 0.079 0.000
I84 Haemorrhoids
0.917 0.083 0.000
H43-H45 Disorders of vitreous body and globe
0.912 0.088 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.910 0.090 0.000
M20.1 Hallux valgus (acquired)
0.906 0.094 0.000
H53-H54 Visual disturbances and blindness
0.901 0.099 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.886 0.114 0.000
I30-I52 Other forms of heart disease
0.881 0.119 0.000
Chapter II Neoplasms
0.872 0.128 0.000
M23.3 Other meniscus derangements
0.871 0.129 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.868 0.132 0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)
0.864 0.136 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.862 0.138 0.000
H43 Disorders of vitreous body
0.861 0.139 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.858 0.142 0.000
I20-I25 Ischaemic heart diseases
0.853 0.147 0.000
I60-I69 Cerebrovascular diseases
0.852 0.148 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.847 0.153 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.844 0.156 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.844 0.156 0.000
H53 Visual disturbances
0.837 0.163 0.000
C79 Secondary malignant neoplasm of other sites
0.836 0.164 0.000
I34 Nonrheumatic mitral valve disorders
0.829 0.171 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.828 0.172 0.000
I84.2 Internal haemorrhoids without complication
0.828 0.172 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.819 0.181 0.000
M86-M90 Other osteopathies
0.812 0.188 0.000
H50 Other strabismus
0.810 0.190 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.810 0.190 0.000
H43.8 Other disorders of vitreous body
0.810 0.190 0.000
H04 Disorders of lachrymal system
0.809 0.191 0.000
I84.6 Residual haemorrhoidal skin tags
0.808 0.192 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.807 0.193 0.000
I84.4 External haemorrhoids with other complications
0.806 0.194 0.000
D70 Agranulocytosis
0.806 0.194 0.000
I84.8 Unspecified haemorrhoids with other complications
0.806 0.194 0.000
I85 Oesophageal varices
0.801 0.199 0.000
I71 Aortic aneurysm and dissection
0.799 0.201 0.000
I34.0 Mitral (valve) insufficiency
0.799 0.201 0.000
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)
0.797 0.203 0.000
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)
0.795 0.205 0.000
I87 Other disorders of veins
0.794 0.206 0.000
G90-G99 Other disorders of the nervous system
0.793 0.207 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.788 0.212 0.000
H30-H36 Disorders of choroid and retina
0.787 0.213 0.000
M35 Other systemic involvement of connective tissue
0.785 0.215 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.783 0.217 0.000
H55-H59 Other disorders of eye and adnexa
0.781 0.219 0.000
I45 Other conduction disorders
0.779 0.221 0.000
M24 Other specific joint derangements
0.777 0.222 0.000
M23.6 Other spontaneous disruption of ligament(s) of knee
0.777 0.223 0.000
Chapter XXII Codes for special purposes
0.776 0.224 0.000
I86 Varicose veins of other sites
0.774 0.226 0.000
C15-C26 Malignant neoplasms of digestive organs
0.771 0.229 0.000
I74 Arterial embolism and thrombosis
0.770 0.230 0.000
H53.4 Visual field defects
0.767 0.233 0.000
I21 Acute myocardial infarction
0.761 0.239 0.000
M80-M85 Disorders of bone density and structure
0.760 0.240 0.000
I89.0 Lymphoedema, not elsewhere classified
0.759 0.241 0.000
H02 Other disorders of eyelid
0.752 0.248 0.000
Chapter I Certain infectious and parasitic diseases
0.751 0.249 0.000
I80 Phlebitis and thrombophlebitis
0.750 0.250 0.000
I84.7 Unspecified thrombosed haemorrhoids
0.747 0.253 0.000
I82 Other venous embolism and thrombosis
0.746 0.254 0.000
H50.1 Divergent concomitant strabismus
0.745 0.255 0.000
I77 Other disorders of arteries and arterioles
0.745 0.255 0.000
M34 Systemic sclerosis
0.745 0.255 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.744 0.256 0.000
M21 Other acquired deformities of limbs
0.743 0.257 0.000
M23.30 Other meniscus derangements (Multiple sites)
0.743 0.257 0.000
I31 Other diseases of pericardium
0.743 0.257 0.000
M40-M43 Deforming dorsopathies
0.742 0.258 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.740 0.260 0.000
C79.6 Secondary malignant neoplasm of ovary
0.738 0.262 0.000
G81 Hemiplegia
0.737 0.263 0.000
M22 Disorders of patella
0.737 0.263 0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)
0.736 0.264 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.734 0.266 0.000
C79.9 Secondary malignant neoplasm, unspecified site
0.733 0.267 0.000
I69 Sequelae of cerebrovascular disease
0.732 0.268 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.729 0.271 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.728 0.272 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.728 0.272 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.725 0.274 0.000
H16 Keratitis
0.725 0.275 0.000
I63 Cerebral infarction
0.724 0.276 0.000
H10-H13 Disorders of conjunctiva
0.724 0.276 0.000
H01 Other inflammation of eyelid
0.723 0.277 0.000
H00 Hordeolum and chalazion
0.722 0.278 0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.721 0.279 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.716 0.284 0.000
I62 Other nontraumatic intracranial haemorrhage
0.715 0.284 0.000
I05-I09 Chronic rheumatic heart diseases
0.713 0.287 0.000
A30-A49 Other bacterial diseases
0.712 0.288 0.000
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)
0.710 0.290 0.000
I00-I02 Acute rheumatic fever
0.708 0.292 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.707 0.293 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.706 0.294 0.000
H05 Disorders of orbit
0.706 0.294 0.000
H53.0 Amblyopia ex anopsia
0.706 0.294 0.000
I95 Hypotension
0.705 0.295 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.705 0.295 0.000
M33 Dermatopolymyositis
0.705 0.295 0.000
M32 Systemic lupus erythematosus
0.705 0.295 0.000
M30 Polyarteritis nodosa and related conditions
0.705 0.295 0.000
M91-M94 Chondropathies
0.704 0.295 0.000
M60-M63 Disorders of muscles
0.704 0.295 0.000
M00-M03 Infectious arthropathies
0.704 0.295 0.000
H53.1 Subjective visual disturbances
0.704 0.296 0.000
I88 Nonspecific lymphadenitis
0.701 0.299 0.000
I81 Portal vein thrombosis
0.701 0.299 0.000
G20-G26 Extrapyramidal and movement disorders
0.701 0.299 0.000
M45-M49 Spondylopathies
0.701 0.299 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.697 0.303 0.000
H43.1 Vitreous haemorrhage
0.697 0.303 0.000
Q50-Q56 Congenital malformations of genital organs
0.696 0.304 0.000
I46 Cardiac arrest
0.696 0.304 0.000
M23.9 Internal derangement of knee, unspecified
0.695 0.304 0.000
M23.5 Chronic instability of knee
0.695 0.304 0.000
M23.1 Discoid meniscus (congenital)
0.695 0.304 0.000
M23.0 Cystic meniscus
0.695 0.304 0.000
I23 Certain current complications following acute myocardial infarction
0.694 0.306 0.000
M23.4 Loose body in knee
0.689 0.311 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.686 0.314 0.000
H33 Retinal detachments and breaks
0.684 0.316 0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.684 0.316 0.000
H04.1 Other disorders of lachrymal gland
0.683 0.317 0.000
I70 Atherosclerosis
0.682 0.318 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.681 0.318 0.000
I42 Cardiomyopathy
0.681 0.318 0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)
0.678 0.322 0.000
I25 Chronic ischaemic heart disease
0.676 0.324 0.000
H18 Other disorders of cornea
0.675 0.325 0.000
I85.9 Oesophageal varices without bleeding
0.674 0.326 0.000
M20.3 Other deformity of hallux (acquired)
0.673 0.327 0.000
Chapter XIV Diseases of the genitourinary system
0.673 0.327 0.000
I45.6 Preexcitation syndrome
0.673 0.327 0.000
G81.9 Hemiplegia, unspecified
0.672 0.328 0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular
0.672 0.328 0.000
I36 Nonrheumatic tricuspid valve disorders
0.671 0.329 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.669 0.330 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.669 0.331 0.000
I87.1 Compression of vein
0.669 0.331 0.000
I22 Subsequent myocardial infarction
0.669 0.331 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.668 0.332 0.000
A49 Bacterial infection of unspecified site
0.667 0.333 0.000
I89.1 Lymphangitis
0.667 0.333 0.000
H02.5 Other disorders affecting eyelid function
0.667 0.333 0.000
H20 Iridocyclitis
0.666 0.334 0.000
M23.8 Other internal derangements of knee
0.666 0.334 0.000
M65-M68 Disorders of synovium and tendon
0.663 0.336 0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.663 0.337 0.000
M31 Other necrotising vasculopathies
0.663 0.337 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.661 0.339 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.661 0.339 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.661 0.339 0.000
N40-N51 Diseases of male genital organs
0.660 0.340 0.000
G93 Other disorders of brain
0.660 0.340 0.000
M23.36 Other meniscus derangements (Other and unspecified lateral meniscus)
0.659 0.341 0.000
I83 Varicose veins of lower extremities
0.659 0.341 0.000
I99 Other and unspecified disorders of circulatory system
0.659 0.341 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.659 0.341 0.000
H54 Blindness and low vision
0.659 0.341 0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.658 0.342 0.000
I84.0 Internal thrombosed haemorrhoids
0.657 0.342 0.000
G70-G73 Diseases of myoneural junction and muscle
0.655 0.344 0.000
H45 Disorders of vitreous body and globe in diseases classified elsewhere
0.654 0.346 0.000
M20.0 Deformity of finger(s)
0.653 0.347 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.653 0.347 0.000
I72 Other aneurysm
0.653 0.347 0.000
I31.9 Disease of pericardium, unspecified
0.650 0.350 0.000
H50.9 Strabismus, unspecified
0.649 0.350 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.648 0.352 0.000
H52 Disorders of refraction and accommodation
0.648 0.352 0.000
M35.0 Sicca syndrome [Sjogren]
0.647 0.353 0.000
H47 Other disorders of optic [2nd] nerve and visual pathways
0.646 0.354 0.000
M86 Osteomyelitis
0.645 0.355 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.644 0.356 0.000
H21 Other disorders of iris and ciliary body
0.644 0.356 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.643 0.357 0.000
H44 Disorders of globe
0.643 0.357 0.000
C60-C63 Malignant neoplasms of male genital organs
0.640 0.360 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.640 0.360 0.000
M23.61 Other spontaneous disruption of ligament(s) of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.639 0.360 0.000
C16 Malignant neoplasm of stomach
0.639 0.361 0.000
C92 Myeloid leukaemia
0.638 0.362 0.000
I60 Subarachnoid haemorrhage
0.637 0.363 0.000
N43 Hydrocele and spermatocele
0.636 0.364 0.000
M88 Paget's disease of bone [osteitis deformans]
0.636 0.364 0.000
H51 Other disorders of binocular movement
0.635 0.365 0.000
H49 Paralytic strabismus
0.635 0.365 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.635 0.365 0.000
I30 Acute pericarditis
0.633 0.367 0.000
I52 Other heart disorders in diseases classified elsewhere
0.631 0.369 0.000
I48 Atrial fibrillation and flutter
0.631 0.369 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.631 0.369 0.000
I41 Myocarditis in diseases classified elsewhere
0.631 0.369 0.000
I40 Acute myocarditis
0.631 0.369 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.631 0.369 0.000
I37 Pulmonary valve disorders
0.631 0.369 0.000
I32 Pericarditis in diseases classified elsewhere
0.631 0.369 0.000
M50-M54 Other dorsopathies
0.631 0.369 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.631 0.369 0.000
I33 Acute and subacute endocarditis
0.630 0.370 0.000
C81 Hodgkin's disease
0.629 0.371 0.000
G83 Other paralytic syndromes
0.629 0.371 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.629 0.371 0.000
I86.1 Scrotal varices
0.627 0.373 0.000
N47 Redundant prepuce, phimosis and paraphimosis
0.627 0.373 0.000
I77.1 Stricture of artery
0.626 0.374 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.625 0.375 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.625 0.375 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.625 0.375 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.625 0.375 0.000
M23.37 Other meniscus derangements-Capsular lig
0.624 0.375 0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)
0.624 0.375 0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.624 0.375 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.624 0.376 0.000
G90 Disorders of autonomic nervous system
0.623 0.377 0.000
H16.0 Corneal ulcer
0.623 0.377 0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.623 0.377 0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere
0.622 0.377 0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere
0.622 0.377 0.000
H17 Corneal scars and opacities
0.622 0.377 0.000
H15 Disorders of sclera
0.622 0.377 0.000
C85.1 B-cell lymphoma, unspecified
0.622 0.378 0.000
H59 Postprocedural disorders of eye and adnexa, not elsewhere classified
0.621 0.378 0.000
C71 Malignant neoplasm of brain
0.621 0.379 0.000
C80 Malignant neoplasm without specification of site
0.621 0.379 0.000
M20.4 Other hammer toe(s) (acquired)
0.620 0.379 0.000
H33.2 Serous retinal detachment
0.620 0.380 0.000
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.620 0.380 0.000
I78 Diseases of capillaries
0.620 0.380 0.000
I21.4 Acute subendocardial myocardial infarction
0.619 0.381 0.000
N43.3 Hydrocele, unspecified
0.619 0.381 0.000
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.618 0.382 0.000
I89.8 Other specified non-infective disorders of lymphatic vessels and lymph nodes
0.618 0.382 0.000
H43.9 Disorder of vitreous body, unspecified
0.618 0.382 0.000
H43.2 Crystalline deposits in vitreous body
0.618 0.382 0.000
H43.0 Vitreous prolapse
0.618 0.382 0.000
I62.0 Subdural haemorrhage (acute) (nontraumatic)
0.618 0.382 0.000
I98 Other disorders of circulatory system in diseases classified elsewhere
0.617 0.383 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.616 0.384 0.000
G54 Nerve root and plexus disorders
0.616 0.384 0.000
G80 Infantile cerebral palsy
0.616 0.384 0.000
G58 Other mononeuropathies
0.615 0.385 0.000
Q90-Q99 Chromosomal abnormalities, not elsewhere classified
0.615 0.385 0.000
Q80-Q89 Other congenital malformations
0.615 0.385 0.000
Q35-Q37 Cleft lip and cleft palate
0.615 0.385 0.000
Q30-Q34 Congenital malformations of the respiratory system
0.615 0.385 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.615 0.385 0.000
Q00-Q07 Congenital malformations of the nervous system
0.615 0.385 0.000
C79.2 Secondary malignant neoplasm of skin
0.615 0.385 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.614 0.386 0.000
I74.5 Embolism and thrombosis of iliac artery
0.614 0.386 0.000
I45.1 Other and unspecified right bundle-branch block
0.612 0.388 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.611 0.389 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.611 0.389 0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)
0.611 0.389 0.000
H02.3 Blepharochalasis
0.610 0.390 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.610 0.390 0.000
G40-G47 Episodic and paroxysmal disorders
0.610 0.390 0.000
M24.5 Contracture of joint
0.610 0.390 0.000
I67 Other cerebrovascular diseases
0.610 0.390 0.000
D80-D89 Certain disorders involving the immune mechanism
0.609 0.391 0.000
C21 Malignant neoplasm of anus and anal canal
0.608 0.392 0.000
H43.3 Other vitreous opacities
0.608 0.392 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.608 0.392 0.000
I61 Intracerebral haemorrhage
0.607 0.393 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.606 0.394 0.000
D55-D59 Haemolytic anaemias
0.605 0.395 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.605 0.395 0.000
G82 Paraplegia and tetraplegia
0.603 0.397 0.000
M05-M14 Inflammatory polyarthropathies
0.603 0.397 0.000
I82.2 Embolism and thrombosis of vena cava
0.601 0.399 0.000
H53.6 Night blindness
0.600 0.400 0.000
H53.5 Colour vision deficiencies
0.600 0.400 0.000
H53.3 Other disorders of binocular vision
0.600 0.400 0.000
I38 Endocarditis, valve unspecified
0.600 0.400 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.599 0.401 0.000
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.599 0.401 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.599 0.401 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.599 0.401 0.000
I83.0 Varicose veins of lower extremities with ulcer
0.599 0.401 0.000
I84.5 External haemorrhoids without complication
0.598 0.402 0.000
I95.9 Hypotension, unspecified
0.598 0.402 0.000
H58 Other disorders of eye and adnexa in diseases classified elsewhere
0.597 0.402 0.000
M20.2 Hallux rigidus
0.597 0.403 0.000
A49.8 Other bacterial infections of unspecified site
0.596 0.404 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.595 0.405 0.000
M84 Disorders of continuity of bone
0.595 0.405 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.594 0.406 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.594 0.406 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.594 0.406 0.000
C51-C58 Malignant neoplasms of female genital organs
0.593 0.407 0.000
I80.1 Phlebitis and thrombophlebitis of femoral vein
0.593 0.407 0.000
M25 Other joint disorders, not elsewhere classified
0.591 0.409 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.591 0.409 0.000
M89 Other disorders of bone
0.591 0.409 0.000
C20 Malignant neoplasm of rectum
0.590 0.410 0.000
I46.0 Cardiac arrest with successful resuscitation
0.589 0.411 0.000
Q60-Q64 Congenital malformations of the urinary system
0.588 0.412 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.587 0.413 0.000
D74 Methaemoglobinaemia
0.587 0.413 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.587 0.413 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.587 0.413 0.000
H02.4 Ptosis of eyelid
0.586 0.414 0.000
I80.9 Phlebitis and thrombophlebitis of unspecified site
0.584 0.415 0.000
I87.8 Other specified disorders of veins
0.584 0.416 0.000
A41 Other septicaemia
0.583 0.417 0.000
D75 Other diseases of blood and blood-forming organs
0.582 0.418 0.000
M90 Osteopathies in diseases classified elsewhere
0.582 0.418 0.000
M87 Osteonecrosis
0.582 0.418 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.581 0.419 0.000
H50.8 Other specified strabismus
0.581 0.419 0.000
H50.6 Mechanical strabismus
0.581 0.419 0.000
H50.5 Heterophoria
0.581 0.419 0.000
H50.4 Other and unspecified heterotropia
0.581 0.419 0.000
H50.3 Intermittent heterotropia
0.581 0.419 0.000
H50.2 Vertical strabismus
0.581 0.419 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.581 0.419 0.000
G52 Disorders of other cranial nerves
0.581 0.419 0.000
I45.5 Other specified heart block
0.580 0.420 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.580 0.420 0.000
D73 Diseases of spleen
0.580 0.420 0.000
H04.9 Disorder of lachrymal system, unspecified
0.580 0.420 0.000
H04.8 Other disorders of lachrymal system
0.580 0.420 0.000
H04.6 Other changes in lachrymal passages
0.580 0.420 0.000
H04.4 Chronic inflammation of lachrymal passages
0.580 0.420 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.580 0.420 0.000
H04.0 Dacryoadenitis
0.580 0.420 0.000
I23.8 Other current complications following acute myocardial infarction
0.580 0.420 0.000
H06.2 Dysthyroid exophthalmos
0.580 0.420 0.000
Q51 Congenital malformations of uterus and cervix
0.579 0.420 0.000
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.579 0.421 0.000
I84.3 External thrombosed haemorrhoids
0.579 0.421 0.000
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.579 0.421 0.000
C95 Leukaemia of unspecified cell type
0.579 0.421 0.000
C94 Other leukaemias of specified cell type
0.579 0.421 0.000
C93 Monocytic leukaemia
0.579 0.421 0.000
C88 Malignant immunoproliferative diseases
0.579 0.421 0.000
C86 Other specified types of T/NK-cell lymphoma
0.579 0.421 0.000
C84 Peripheral and cutaneous T-cell lymphomas
0.579 0.421 0.000
G91 Hydrocephalus
0.575 0.425 0.000
M24.1 Other articular cartilage disorders
0.575 0.425 0.000
N60-N64 Disorders of breast
0.575 0.425 0.000
I85.0 Oesophageal varices with bleeding
0.574 0.426 0.000
M34.9 Systemic sclerosis, unspecified
0.574 0.426 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.573 0.427 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.573 0.427 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.573 0.427 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.573 0.427 0.000
I71.0 Dissection of aorta [any part]
0.573 0.427 0.000
M43 Other deforming dorsopathies
0.572 0.428 0.000
I51 Complications and ill-defined descriptions of heart disease
0.572 0.428 0.000
H53.9 Visual disturbance, unspecified
0.572 0.428 0.000
Chapter XX External causes of morbidity and mortality
0.572 0.428 0.000
H01.0 Blepharitis
0.572 0.428 0.000
I05 Rheumatic mitral valve diseases
0.570 0.430 0.000
G24 Dystonia
0.569 0.431 0.000
I87.9 Disorder of vein, unspecified
0.569 0.431 0.000
I87.0 Postphlebitic syndrome
0.569 0.431 0.000
G96 Other disorders of central nervous system
0.569 0.431 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.569 0.431 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.569 0.431 0.000
G92 Toxic encephalopathy
0.569 0.431 0.000
M22.2 Patellofemoral disorders
0.568 0.432 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.568 0.432 0.000
I24 Other acute ischaemic heart diseases
0.568 0.432 0.000
H57 Other disorders of eye and adnexa
0.566 0.433 0.000
I63.9 Cerebral infarction, unspecified
0.565 0.435 0.000
H48 Disorders of optic [2nd] nerve and visual pathways in diseases classified elsewhere
0.565 0.435 0.000
H46 Optic neuritis
0.565 0.435 0.000
H32 Chorioretinal disorders in diseases classified elsewhere
0.564 0.435 0.000
H31 Other disorders of choroid
0.564 0.435 0.000
H30 Chorioretinal inflammation
0.564 0.435 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.565 0.435 0.000
I25.2 Old myocardial infarction
0.564 0.436 0.000
M21.0 Valgus deformity, not elsewhere classified
0.564 0.436 0.000
G50 Disorders of trigeminal nerve
0.563 0.436 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.563 0.437 0.000
M80 Osteoporosis with pathological fracture
0.563 0.437 0.000
M95 Other acquired deformities of musculoskeletal system and connective tissue
0.563 0.437 0.000
M35.9 Systemic involvement of connective tissue, unspecified
0.563 0.437 0.000
M35.8 Other specified systemic involvement of connective tissue
0.563 0.437 0.000
M35.7 Hypermobility syndrome
0.563 0.437 0.000
M35.6 Relapsing panniculitis [Weber-Christian]
0.563 0.437 0.000
M35.5 Multifocal fibrosclerosis
0.563 0.437 0.000
M35.4 Diffuse (eosinophilic) fasciitis
0.563 0.437 0.000
M35.2 Behcet's disease
0.563 0.437 0.000
M35.1 Other overlap syndromes
0.563 0.437 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.561 0.438 0.000
H40-H42 Glaucoma
0.561 0.439 0.000
H36 Retinal disorders in diseases classified elsewhere
0.560 0.440 0.000
N99-N99 Other disorders of the genitourinary system
0.560 0.440 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.559 0.441 0.000
M45 Ankylosing spondylitis
0.559 0.441 0.000
I45.9 Conduction disorder, unspecified
0.559 0.441 0.000
I45.8 Other specified conduction disorders
0.559 0.441 0.000
I45.4 Nonspecific intraventricular block
0.559 0.441 0.000
I45.3 Trifascicular block
0.559 0.441 0.000
I45.2 Bifascicular block
0.559 0.441 0.000
I45.0 Right fascicular block
0.559 0.441 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.558 0.442 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.558 0.442 0.000
M24.9 Joint derangement, unspecified
0.557 0.442 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.557 0.442 0.000
M24.7 Protrusio acetabuli
0.557 0.442 0.000
M24.6 Ankylosis of joint
0.557 0.442 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.557 0.442 0.000
M24.2 Disorder of ligament
0.557 0.442 0.000
M24.0 Loose body in joint
0.557 0.442 0.000
M23.69 Other spontaneous disruption of ligament(s) of knee (Unspecified ligament or Unspecified meniscus)
0.557 0.442 0.000
M23.67 Other spontaneous disruption of ligament(s) of knee (Capsular ligament)
0.557 0.442 0.000
M23.66 Other spontaneous disruption of ligament(s) of knee-O/unsp
0.557 0.442 0.000
M23.65 Other spontaneous disruption of ligament(s) of knee-Pst hrn
0.557 0.442 0.000
M23.64 Other spontaneous disruption of ligament(s) of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)
0.557 0.442 0.000
M23.63 Other spontaneous disruption of ligament(s) of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.557 0.442 0.000
M23.62 Other spontaneous disruption of ligament(s) of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)
0.557 0.442 0.000
M23.60 Other spontaneous disruption of ligament(s) of knee (Multiple sites)
0.557 0.442 0.000
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
0.557 0.443 0.000
M35.3 Polymyalgia rheumatica
0.557 0.443 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.557 0.443 0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries
0.556 0.444 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.556 0.444 0.000
I86.8 Varicose veins of other specified sites
0.555 0.445 0.000
I86.4 Gastric varices
0.555 0.445 0.000
I86.3 Vulval varices
0.555 0.445 0.000
I86.2 Pelvic varices
0.555 0.445 0.000
I86.0 Sublingual varices
0.555 0.445 0.000
C16.9 Stomach, unspecified
0.554 0.446 0.000
A49.1 Streptococcal infection, unspecified
0.553 0.447 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.553 0.447 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.553 0.447 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.553 0.447 0.000
C17 Malignant neoplasm of small intestine
0.553 0.447 0.000
C23 Malignant neoplasm of gallbladder
0.553 0.447 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.552 0.447 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.552 0.448 0.000
I74.8 Embolism and thrombosis of other arteries
0.552 0.448 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.552 0.448 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.552 0.448 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.552 0.448 0.000
H33.3 Retinal breaks without detachment
0.552 0.448 0.000
H00.1 Chalazion
0.552 0.448 0.000
C50-C50 Malignant neoplasm of breast
0.552 0.448 0.000
M81 Osteoporosis without pathological fracture
0.552 0.448 0.000
G95 Other diseases of spinal cord
0.551 0.449 0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)
0.550 0.450 0.000
H34 Retinal vascular occlusions
0.549 0.451 0.000
I22.8 Subsequent myocardial infarction of other sites
0.548 0.452 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.546 0.454 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.546 0.454 0.000
C18 Malignant neoplasm of colon
0.546 0.454 0.000
G57 Mononeuropathies of lower limb
0.545 0.455 0.000
M83 Adult osteomalacia
0.545 0.455 0.000
M82 Osteoporosis in diseases classified elsewhere
0.545 0.455 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.545 0.455 0.000
I73 Other peripheral vascular diseases
0.544 0.456 0.000
O60-O75 Complications of labour and delivery
0.544 0.456 0.000
M21.1 Varus deformity, not elsewhere classified
0.543 0.456 0.000
H05.0 Acute inflammation of orbit
0.542 0.457 0.000
H50.0 Convergent concomitant strabismus
0.542 0.458 0.000
M22.8 Other disorders of patella
0.542 0.458 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.541 0.459 0.000
I34.1 Mitral (valve) prolapse
0.541 0.459 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.541 0.459 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.541 0.459 0.000
Q21 Congenital malformations of cardiac septa
0.540 0.460 0.000
H00.0 Hordeolum and other deep inflammation of eyelid
0.540 0.460 0.000
C90 Multiple myeloma and malignant plasma cell neoplasms
0.540 0.460 0.000
I25.5 Ischaemic cardiomyopathy
0.540 0.460 0.000
I80.8 Phlebitis and thrombophlebitis of other sites
0.539 0.461 0.000
I87.2 Venous insufficiency (chronic) (peripheral)
0.539 0.461 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.539 0.461 0.000
H02.2 Lagophthalmos
0.539 0.461 0.000
B99-B99 Other infectious diseases
0.538 0.461 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.538 0.461 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.538 0.461 0.000
B65-B83 Helminthiases
0.538 0.461 0.000
B50-B64 Protozoal diseases
0.538 0.461 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.538 0.461 0.000
B15-B19 Viral hepatitis
0.538 0.461 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.538 0.461 0.000
A80-A89 Viral infections of the central nervous system
0.538 0.461 0.000
A75-A79 Rickettsioses
0.538 0.461 0.000
A70-A74 Other diseases caused by chlamydiae
0.538 0.461 0.000
A65-A69 Other spirochaetal diseases
0.538 0.461 0.000
A20-A28 Certain zoonotic bacterial diseases
0.538 0.461 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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