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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1421085
log Bayes Factor = 51.7214
Chromosome 16   position 53,800,954  (GRCh37) Explore rs1421085 on Ensembl!
Variant rs1421085 is listed in the   GWAS Catalog   ⇪
Variant rs1421085 is part of Cluster X0314

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E11.9 Without complications
1.000 0.000 0.000
E66.9 Obesity, unspecified
1.000 0.000 0.000
E66.8 Other obesity
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
1.000 0.000 0.000
E66 Obesity
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.999 0.001 0.000
E65-E68 Obesity and other hyperalimentation
0.998 0.002 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.996 0.004 0.000
E11.4 With neurological complications
0.996 0.004 0.000
E14 Unspecified diabetes mellitus
0.982 0.018 0.000
E11.5 With peripheral circulatory complications
0.976 0.024 0.000
E14.9 Without complications
0.975 0.025 0.000
K66.0 Peritoneal adhesions
0.964 0.036 0.000
M17.0 Primary gonarthrosis, bilateral
0.936 0.064 0.000
M17 Gonarthrosis [arthrosis of knee]
0.932 0.068 0.000
E20-E35 Disorders of other endocrine glands
0.931 0.069 0.000
M15-M19 Arthrosis
0.923 0.077 0.000
M16 Coxarthrosis [arthrosis of hip]
0.913 0.087 0.000
M18 Arthrosis of first carpometacarpal joint
0.903 0.097 0.000
E27 Other disorders of adrenal gland
0.896 0.104 0.000
E11.3 With ophthalmic complications
0.891 0.109 0.000
M17.9 Gonarthrosis, unspecified
0.885 0.115 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.873 0.127 0.000
M18.1 Other primary arthrosis of first carpometacarpal joint
0.873 0.127 0.000
G47.3 Sleep apnoea
0.870 0.130 0.000
M16.9 Coxarthrosis, unspecified
0.869 0.131 0.000
E24 Cushing's syndrome
0.868 0.132 0.000
M18.0 Primary arthrosis of first carpometacarpal joints, bilateral
0.858 0.142 0.000
E27.2 Addisonian crisis
0.847 0.153 0.000
M16.1 Other primary coxarthrosis
0.839 0.161 0.000
G56.0 Carpal tunnel syndrome
0.835 0.165 0.000
E65 Localised adiposity
0.833 0.167 0.000
E66.0 Obesity due to excess calories
0.827 0.173 0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral
0.814 0.186 0.000
L03.1 Cellulitis of other parts of limb
0.803 0.197 0.000
E14.4 With neurological complications
0.786 0.214 0.000
L03 Cellulitis
0.785 0.215 0.000
L02.2 Cutaneous abscess, furuncle and carbuncle of trunk
0.783 0.217 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.782 0.218 0.000
E24.9 Cushing's syndrome, unspecified
0.781 0.219 0.000
E14.6 With other specified complications
0.780 0.220 0.000
L00-L08 Infections of the skin and subcutaneous tissue
0.777 0.223 0.000
L02 Cutaneous abscess, furuncle and carbuncle
0.777 0.223 0.000
E27.9 Disorder of adrenal gland, unspecified
0.776 0.224 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.774 0.226 0.000
G47 Sleep disorders
0.772 0.228 0.000
M16.3 Other dysplastic coxarthrosis
0.771 0.229 0.000
M17.4 Other secondary gonarthrosis, bilateral
0.768 0.232 0.000
G62 Other polyneuropathies
0.764 0.236 0.000
G56 Mononeuropathies of upper limb
0.764 0.236 0.000
E14.1 With ketoacidosis
0.762 0.238 0.000
E11.8 With unspecified complications
0.760 0.240 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.760 0.240 0.000
Chapter VI Diseases of the nervous system
0.759 0.241 0.000
E11.6 With other specified complications
0.759 0.241 0.000
G40-G47 Episodic and paroxysmal disorders
0.754 0.246 0.000
G63 Polyneuropathy in diseases classified elsewhere
0.753 0.246 0.000
E25 Adrenogenital disorders
0.752 0.248 0.000
E40-E46 Malnutrition
0.745 0.255 0.000
G63.2 Diabetic polyneuropathy
0.739 0.261 0.000
L05 Pilonidal cyst
0.732 0.268 0.000
L03.8 Cellulitis of other sites
0.732 0.268 0.000
M17.1 Other primary gonarthrosis
0.732 0.268 0.000
M16.0 Primary coxarthrosis, bilateral
0.726 0.274 0.000
E11.1 With ketoacidosis
0.725 0.275 0.000
G41 Status epilepticus
0.723 0.277 0.000
E26 Hyperaldosteronism
0.721 0.278 0.000
E11.7 With multiple complications
0.718 0.282 0.000
E66.1 Drug-induced obesity
0.717 0.283 0.000
G62.8 Other specified polyneuropathies
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.716 0.284 0.000
E67 Other hyperalimentation
0.716 0.284 0.000
E68 Sequelae of hyperalimentation
0.716 0.284 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.715 0.285 0.000
M18.3 Other posttraumatic arthrosis of first carpometacarpal joint
0.708 0.292 0.000
G62.9 Polyneuropathy, unspecified
0.706 0.294 0.000
G51 Facial nerve disorders
0.705 0.295 0.000
E14.7 With multiple complications
0.704 0.296 0.000
E14.0 With coma
0.704 0.296 0.000
L05.9 Pilonidal cyst without abscess
0.704 0.296 0.000
G41.9 Status epilepticus, unspecified
0.703 0.297 0.000
E13 Other specified diabetes mellitus
0.702 0.298 0.000
G61 Inflammatory polyneuropathy
0.699 0.301 0.000
E24.0 Pituitary-dependent Cushing's disease
0.698 0.302 0.000
M15 Polyarthrosis
0.697 0.303 0.000
I10 Essential (primary) hypertension
0.691 0.309 0.000
G59.0 Diabetic mononeuropathy
0.684 0.316 0.000
E24.2 Drug-induced Cushing's syndrome
0.682 0.318 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.679 0.321 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.667 0.333 0.000
E32 Diseases of thymus
0.667 0.333 0.000
E30 Disorders of puberty, not elsewhere classified
0.667 0.333 0.000
E14.5 With peripheral circulatory complications
0.665 0.335 0.000
L02.4 Cutaneous abscess, furuncle and carbuncle of limb
0.662 0.338 0.000
E31 Polyglandular dysfunction
0.661 0.339 0.000
E27.1 Primary adrenocortical insufficiency
0.657 0.343 0.000
M16.4 Posttraumatic coxarthrosis, bilateral
0.654 0.346 0.000
E11.2 With renal complications
0.654 0.346 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.652 0.347 0.000
E21.0 Primary hyperparathyroidism
0.649 0.351 0.000
M18.5 Other secondary arthrosis of first carpometacarpal joint
0.648 0.352 0.000
M18.4 Other secondary arthrosis of first carpometacarpal joints, bilateral
0.648 0.352 0.000
M18.2 Posttraumatic arthrosis of first carpometacarpal joints, bilateral
0.648 0.352 0.000
G51.9 Disorder of facial nerve, unspecified
0.647 0.353 0.000
G51.0 Bell's palsy
0.646 0.354 0.000
M17.2 Posttraumatic gonarthrosis, bilateral
0.643 0.357 0.000
E27.5 Adrenomedullary hyperfunction
0.642 0.358 0.000
E27.0 Other adrenocortical overactivity
0.642 0.358 0.000
E21.2 Other hyperparathyroidism
0.641 0.359 0.000
G61.0 Guillain-Barre syndrome
0.631 0.369 0.000
E14.8 With unspecified complications
0.626 0.373 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.624 0.375 0.000
E24.8 Other Cushing's syndrome
0.622 0.378 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.622 0.378 0.000
E24.3 Ectopic ACTH syndrome
0.622 0.378 0.000
E24.1 Nelson's syndrome
0.622 0.378 0.000
G62.1 Alcoholic polyneuropathy
0.621 0.379 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.619 0.381 0.000
E20 Hypoparathyroidism
0.617 0.383 0.000
L02.0 Cutaneous abscess, furuncle and carbuncle of face
0.610 0.390 0.000
E28 Ovarian dysfunction
0.609 0.391 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.607 0.393 0.000
L02.8 Cutaneous abscess, furuncle and carbuncle of other sites
0.595 0.405 0.000
L02.9 Cutaneous abscess, furuncle and carbuncle, unspecified
0.591 0.409 0.000
E50-E64 Other nutritional deficiencies
0.588 0.412 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.587 0.413 0.000
G61.9 Inflammatory polyneuropathy, unspecified
0.585 0.415 0.000
L03.3 Cellulitis of trunk
0.575 0.425 0.000
M15.1 Heberden's nodes (with arthropathy)
0.575 0.425 0.000
E14.2 Withrenal complications
0.572 0.428 0.000
E26.0 Primary hyperaldosteronism
0.572 0.428 0.000
G52 Disorders of other cranial nerves
0.571 0.428 0.000
G62.0 Drug-induced polyneuropathy
0.569 0.431 0.000
E46 Unspecified protein-energy malnutrition
0.565 0.435 0.000
M16.6 Other secondary coxarthrosis, bilateral
0.560 0.440 0.000
E13.3 With ophthalmic complications
0.558 0.442 0.000
L00 Staphylococcal scalded skin syndrome
0.557 0.443 0.000
E22 Hyperfunction of pituitary gland
0.556 0.444 0.000
G64 Other disorders of peripheral nervous system
0.555 0.445 0.000
L04 Acute lymphadenitis
0.554 0.446 0.000
G83 Other paralytic syndromes
0.552 0.448 0.000
G56.1 Other lesions of median nerve
0.551 0.449 0.000
E21.4 Other specified disorders of parathyroid gland
0.550 0.449 0.000
G47.9 Sleep disorder, unspecified
0.550 0.450 0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]
0.549 0.451 0.000
G62.2 Polyneuropathy due to other toxic agents
0.548 0.452 0.000
M15.4 Erosive (osteo)arthrosis
0.548 0.452 0.000
M15.9 Polyarthrosis, unspecified
0.542 0.457 0.000
G63.8 Polyneuropathy in other diseases classified elsewhere
0.540 0.460 0.000
G63.6 Polyneuropathy in other musculoskeletal disorders
0.540 0.460 0.000
G63.5 Polyneuropathy in systemic connective tissue disorders
0.540 0.460 0.000
G63.4 Polyneuropathy in nutritional deficiency
0.540 0.460 0.000
G63.3 Polyneuropathy in other endocrine and metabolic diseases
0.540 0.460 0.000
G63.1 Polyneuropathy in neoplastic disease
0.540 0.460 0.000
G63.0 Polyneuropathy in infectious and parasitic diseases classified elsewhere
0.540 0.460 0.000
E25.9 Adrenogenital disorder, unspecified
0.539 0.460 0.000
E25.8 Other adrenogenital disorders
0.539 0.460 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.534 0.466 0.000
E45 Retarded development following protein-energy malnutrition
0.534 0.466 0.000
E43 Unspecified severe protein-energy malnutrition
0.534 0.466 0.000
E42 Marasmic kwashiorkor
0.534 0.466 0.000
E41 Nutritional marasmus
0.534 0.466 0.000
E40 Kwashiorkor
0.534 0.466 0.000
E27.8 Other specified disorders of adrenal gland
0.534 0.466 0.000
K66 Other disorders of peritoneum
0.521 0.479 0.000
G56.8 Other mononeuropathies of upper limb
0.519 0.481 0.000
G41.8 Other status epilepticus
0.518 0.481 0.000
G41.2 Complex partial status epilepticus
0.518 0.481 0.000
G41.1 Petit mal status epilepticus
0.518 0.481 0.000
E26.9 Hyperaldosteronism, unspecified
0.517 0.483 0.000
E26.8 Other hyperaldosteronism
0.517 0.483 0.000
E26.1 Secondary hyperaldosteronism
0.517 0.483 0.000
G47.2 Disorders of the sleep-wake schedule
0.517 0.483 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
E67.8 Other specified hyperalimentation
0.513 0.487 0.000
E67.3 Hypervitaminosis D
0.513 0.487 0.000
E67.2 Megavitamin-B6 syndrome
0.513 0.487 0.000
E67.1 Hypercarotenaemia
0.513 0.487 0.000
E67.0 Hypervitaminosis A
0.513 0.487 0.000
G59.8 Other mononeuropathies in diseases classified elsewhere
0.513 0.487 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.511 0.489 0.000
G60 Hereditary and idiopathic neuropathy
0.507 0.493 0.000
G51.4 Facial myokymia
0.506 0.494 0.000
G51.2 Melkersson's syndrome
0.506 0.494 0.000
G51.1 Geniculate ganglionitis
0.506 0.494 0.000
G41.0 Grand mal status epilepticus
0.505 0.495 0.000
G47.4 Narcolepsy and cataplexy
0.504 0.496 0.000
E13.8 With unspecified complications
0.503 0.497 0.000
E13.7 With multiple complications
0.503 0.497 0.000
E13.6 With other specified complications
0.503 0.497 0.000
E13.5 With peripheral circulatory complications
0.503 0.497 0.000
E13.4 With neurological complications
0.503 0.497 0.000
E13.2 With renal complications
0.503 0.497 0.000
E13.1 With ketoacidosis
0.503 0.497 0.000
E13.0 With coma
0.503 0.497 0.000
G50 Disorders of trigeminal nerve
0.501 0.499 0.000
G61.1 Serum neuropathy
0.501 0.499 0.000
L05.0 Pilonidal cyst with abscess
0.500 0.500 0.000
M15.0 Primary generalised (osteo)arthrosis
0.500 0.500 0.000
M15.3 Secondary multiple arthrosis
0.500 0.500 0.000
E22.0 Acromegaly and pituitary gigantism
0.500 0.500 0.000
M17.5 Other secondary gonarthrosis
0.498 0.501 0.000
L01 Impetigo
0.496 0.504 0.000
M16.7 Other secondary coxarthrosis
0.489 0.511 0.000
E29 Testicular dysfunction
0.489 0.511 0.000
G80 Infantile cerebral palsy
0.486 0.514 0.000
E30.9 Disorder of puberty, unspecified
0.478 0.521 0.000
E30.8 Other disorders of puberty
0.478 0.521 0.000
E30.1 Precocious puberty
0.478 0.521 0.000
E30.0 Delayed puberty
0.478 0.521 0.000
E32.9 Disease of thymus, unspecified
0.478 0.521 0.000
E32.8 Other diseases of thymus
0.478 0.521 0.000
E32.1 Abscess of thymus
0.478 0.521 0.000
E32.0 Persistent hyperplasia of thymus
0.478 0.521 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.478 0.521 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.478 0.521 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.478 0.521 0.000
E31.9 Polyglandular dysfunction, unspecified
0.474 0.526 0.000
E31.8 Other polyglandular dysfunction
0.474 0.526 0.000
E31.1 Polyglandular hyperfunction
0.474 0.526 0.000
G58 Other mononeuropathies
0.473 0.527 0.000
E63 Other nutritional deficiencies
0.472 0.528 0.000
G20-G26 Extrapyramidal and movement disorders
0.471 0.529 0.000
G56.9 Mononeuropathy of upper limb, unspecified
0.471 0.529 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.468 0.531 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.468 0.532 0.000
G46 Vascular syndromes of brain in cerebrovascular diseases
0.468 0.532 0.000
E31.0 Autoimmune polyglandular failure
0.467 0.532 0.000
G56.4 Causalgia
0.467 0.533 0.000
G83.8 Other specified paralytic syndromes
0.458 0.542 0.000
G83.9 Paralytic syndrome, unspecified
0.456 0.544 0.000
E28.2 Polycystic ovarian syndrome
0.456 0.544 0.000
G30-G32 Other degenerative diseases of the nervous system
0.454 0.546 0.000
G47.8 Other sleep disorders
0.454 0.546 0.000
L03.9 Cellulitis, unspecified
0.451 0.549 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.450 0.550 0.000
G52.3 Disorders of hypoglossal nerve
0.448 0.552 0.000
E54 Ascorbic acid deficiency
0.445 0.554 0.000
E20.8 Other hypoparathyroidism
0.442 0.557 0.000
E20.1 Pseudohypoparathyroidism
0.442 0.557 0.000
E20.0 Idiopathic hypoparathyroidism
0.442 0.557 0.000
M16.5 Other posttraumatic coxarthrosis
0.441 0.558 0.000
E28.9 Ovarian dysfunction, unspecified
0.437 0.563 0.000
E28.8 Other ovarian dysfunction
0.437 0.563 0.000
E28.1 Androgen excess
0.437 0.563 0.000
E28.0 Oestrogen excess
0.437 0.563 0.000
G57 Mononeuropathies of lower limb
0.435 0.565 0.000
M15.2 Bouchard's nodes (with arthropathy)
0.435 0.565 0.000
E56 Other vitamin deficiencies
0.434 0.566 0.000
G51.8 Other disorders of facial nerve
0.433 0.566 0.000
M15.99 Polyosteoarthritis, unspecified
0.431 0.568 0.000
G83.2 Monoplegia of upper limb
0.426 0.574 0.000
G56.3 Lesion of radial nerve
0.425 0.574 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.421 0.578 0.000
E50 Vitamin A deficiency
0.421 0.578 0.000
E60 Dietary zinc deficiency
0.421 0.578 0.000
E59 Dietary selenium deficiency
0.421 0.578 0.000
E52 Niacin deficiency [pellagra]
0.421 0.578 0.000
G61.8 Other inflammatory polyneuropathies
0.421 0.579 0.000
L04.0 Acute lymphadenitis of face, head and neck
0.420 0.580 0.000
K66.8 Other specified disorders of peritoneum
0.418 0.582 0.000
G50.8 Other disorders of trigeminal nerve
0.417 0.583 0.000
G58.7 Mononeuritis multiplex
0.417 0.583 0.000
G52.9 Cranial nerve disorder, unspecified
0.416 0.584 0.000
G83.1 Monoplegia of lower limb
0.412 0.588 0.000
E58 Dietary calcium deficiency
0.411 0.589 0.000
G52.7 Disorders of multiple cranial nerves
0.410 0.590 0.000
G52.2 Disorders of vagus nerve
0.410 0.590 0.000
G52.1 Disorders of glossopharyngeal nerve
0.410 0.590 0.000
G52.0 Disorders of olfactory nerve
0.410 0.590 0.000
E13.9 Without complications
0.407 0.593 0.000
G83.4 Cauda equina syndrome
0.406 0.594 0.000
E61 Deficiency of other nutrient elements
0.406 0.594 0.000
G24 Dystonia
0.404 0.596 0.000
G80.9 Infantile cerebral palsy, unspecified
0.403 0.597 0.000
E51 Thiamine deficiency
0.402 0.598 0.000
E11.0 With coma
0.399 0.601 0.001
E22.9 Hyperfunction of pituitary gland, unspecified
0.399 0.601 0.000
E22.8 Other hyperfunction of pituitary gland
0.399 0.601 0.000
L04.8 Acute lymphadenitis of other sites
0.397 0.603 0.000
L04.3 Acute lymphadenitis of lower limb
0.397 0.603 0.000
G47.1 Disorders of excessive somnolence [hypersomnias]
0.396 0.604 0.000
G83.5 Locked-in syndrome
0.396 0.604 0.000
G83.3 Monoplegia, unspecified
0.396 0.604 0.000
G83.0 Diplegia of upper limbs
0.396 0.604 0.000
G60.8 Other hereditary and idiopathic neuropathies
0.395 0.605 0.000
G30 Alzheimer's disease
0.393 0.607 0.000
Z85.3 Personal history of malignant neoplasm of breast
0.000 0.607 0.393
E20.9 Hypoparathyroidism, unspecified
0.392 0.607 0.000
G44 Other headache syndromes
0.392 0.608 0.000
L04.2 Acute lymphadenitis of upper limb
0.392 0.608 0.000
L04.1 Acute lymphadenitis of trunk
0.391 0.608 0.000
G50.9 Disorder of trigeminal nerve, unspecified
0.390 0.610 0.000
E63.9 Nutritional deficiency, unspecified
0.390 0.610 0.000
G52.8 Disorders of other specified cranial nerves
0.387 0.613 0.000
E14.3 With ophthalmic complications
0.387 0.613 0.000
E44.1 Mild protein-energy malnutrition
0.383 0.617 0.000
E44.0 Moderate protein-energy malnutrition
0.383 0.617 0.000
E34 Other endocrine disorders
0.380 0.620 0.000
G60.9 Hereditary and idiopathic neuropathy, unspecified
0.380 0.620 0.000
L04.9 Acute lymphadenitis, unspecified
0.379 0.620 0.000
E21.3 Hyperparathyroidism, unspecified
0.376 0.624 0.000
G80.8 Other infantile cerebral palsy
0.375 0.625 0.000
G03 Meningitis due to other and unspecified causes
0.374 0.626 0.000
G51.3 Clonic hemifacial spasm
0.370 0.630 0.000
G57.5 Tarsal tunnel syndrome
0.369 0.631 0.000
M15.8 Other polyarthrosis
0.368 0.631 0.000
E15 Nondiabetic hypoglycaemic coma
0.366 0.634 0.000
G82 Paraplegia and tetraplegia
0.365 0.635 0.000
G50.1 Atypical facial pain
0.364 0.636 0.000
G60.3 Idiopathic progressive neuropathy
0.364 0.636 0.000
G60.2 Neuropathy in association with hereditary ataxia
0.364 0.636 0.000
G60.1 Refsum's disease
0.364 0.636 0.000
K66.9 Disorder of peritoneum, unspecified
0.362 0.638 0.000
M15.00 Primary generalized (osteo)arthrosis, Multiple sites
0.358 0.641 0.000
G80.2 Infantile hemiplegia
0.359 0.641 0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere
0.358 0.642 0.000
L01.1 Impetiginisation of other dermatoses
0.356 0.644 0.000
G02 Meningitis in other infectious and parasitic diseases classified elsewhere
0.354 0.646 0.000
G57.3 Lesion of lateral popliteal nerve
0.352 0.648 0.000
E29.8 Other testicular dysfunction
0.350 0.649 0.000
E29.0 Testicular hyperfunction
0.350 0.649 0.000
E28.3 Primary ovarian failure
0.349 0.650 0.000
G12 Spinal muscular atrophy and related syndromes
0.349 0.651 0.000
G23 Other degenerative diseases of basal ganglia
0.349 0.651 0.000
G80.4 Ataxic cerebral palsy
0.348 0.652 0.000
G80.3 Dyskinetic cerebral palsy
0.348 0.652 0.000
K66.1 Haemoperitoneum
0.348 0.652 0.000
G01 Meningitis in bacterial diseases classified elsewhere
0.343 0.657 0.000
E63.8 Other specified nutritional deficiencies
0.339 0.661 0.000
E63.1 Imbalance of constituents of food intake
0.339 0.661 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.339 0.661 0.000
G58.0 Intercostal neuropathy
0.339 0.661 0.000
E29.9 Testicular dysfunction, unspecified
0.338 0.662 0.000
G30.0 Alzheimer's disease with early onset
0.338 0.662 0.000
G21 Secondary Parkinsonism
0.338 0.662 0.000
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.338 0.662 0.000
G22 Parkinsonism in diseases classified elsewhere
0.338 0.662 0.000
G24.9 Dystonia, unspecified
0.338 0.662 0.000
M17.3 Other posttraumatic gonarthrosis
0.336 0.663 0.001
G14 Postpolio syndrome
0.336 0.664 0.000
G53.8 Other cranial nerve disorders in other diseases classified elsewhere
0.336 0.664 0.000
G53.3 Multiple cranial nerve palsies in neoplastic disease
0.336 0.664 0.000
G53.2 Multiple cranial nerve palsies in sarcoidosis
0.336 0.664 0.000
G53.1 Multiple cranial nerve palsies in infectious and parasitic diseases classified elsewhere
0.336 0.664 0.000
G46.8 Other vascular syndromes of brain in cerebrovascular diseases
0.335 0.664 0.000
G46.6 Pure sensory lacunar syndrome
0.335 0.664 0.000
G46.5 Pure motor lacunar syndrome
0.335 0.664 0.000
G46.2 Posterior cerebral artery syndrome
0.335 0.664 0.000
G46.1 Anterior cerebral artery syndrome
0.335 0.664 0.000
G46.0 Middle cerebral artery syndrome
0.335 0.664 0.000
E53 Deficiency of other B group vitamins
0.335 0.665 0.000
G46.3 Brain stem stroke syndrome
0.334 0.666 0.000
G57.0 Lesion of sciatic nerve
0.332 0.668 0.000
L03.0 Cellulitis of finger and toe
0.331 0.669 0.000
G04 Encephalitis, myelitis and encephalomyelitis
0.329 0.671 0.000
G80.0 Spastic cerebral palsy
0.329 0.671 0.000
G24.3 Spasmodic torticollis
0.328 0.671 0.000
E56.1 Deficiency of vitamin K
0.324 0.676 0.000
L03.2 Cellulitis of face
0.324 0.676 0.000
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.323 0.677 0.000
G07 Intracranial and intraspinal abscess and granuloma in diseases classified elsewhere
0.322 0.677 0.000
G03.9 Meningitis, unspecified
0.320 0.680 0.000
G46.4 Cerebellar stroke syndrome
0.317 0.683 0.000
E55 Vitamin D deficiency
0.317 0.683 0.000
G80.1 Spastic diplegia
0.317 0.683 0.000
G44.8 Other specified headache syndromes
0.315 0.685 0.000
G57.4 Lesion of medial popliteal nerve
0.312 0.688 0.000
G57.2 Lesion of femoral nerve
0.312 0.688 0.000
G90-G99 Other disorders of the nervous system
0.312 0.688 0.000
E56.9 Vitamin deficiency, unspecified
0.311 0.688 0.000
E56.8 Deficiency of other vitamins
0.311 0.688 0.000
E56.0 Deficiency of vitamin E
0.311 0.688 0.000
G57.8 Other mononeuropathies of lower limb
0.311 0.689 0.000
G30.1 Alzheimer's disease with late onset
0.306 0.693 0.000
G82.5 Tetraplegia, unspecified
0.306 0.694 0.000
G24.1 Idiopathic familial dystonia
0.304 0.696 0.000
E50.9 Vitamin A deficiency, unspecified
0.302 0.698 0.000
E50.8 Other manifestations of vitamin A deficiency
0.302 0.698 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.302 0.698 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.302 0.698 0.000
E50.5 Vitamin A deficiency with night blindness
0.302 0.698 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.302 0.698 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.302 0.698 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.302 0.698 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.302 0.698 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.302 0.698 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.302 0.698 0.000
E64.8 Sequelae of other nutritional deficiencies
0.302 0.698 0.000
E64.3 Sequelae of rickets
0.302 0.698 0.000
E64.2 Sequelae of vitamin C deficiency
0.302 0.698 0.000
E64.1 Sequelae of vitamin A deficiency
0.302 0.698 0.000
E64.0 Sequelae of protein-energy malnutrition
0.302 0.698 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.300 0.700 0.000
G10 Huntington's disease
0.299 0.701 0.000
G30.9 Alzheimer's disease, unspecified
0.297 0.703 0.000
G24.5 Blepharospasm
0.296 0.704 0.000
L01.0 Impetigo [any organism] [any site]
0.294 0.705 0.000
L02.1 Cutaneous abscess, furuncle and carbuncle of neck
0.294 0.706 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.294 0.706 0.000
E61.9 Deficiency of nutrient element, unspecified
0.291 0.709 0.000
E61.8 Deficiency of other specified nutrient elements
0.291 0.709 0.000
E61.7 Deficiency of multiple nutrient elements
0.291 0.709 0.000
E61.6 Vanadium deficiency
0.291 0.709 0.000
E61.5 Molybdenum deficiency
0.291 0.709 0.000
E61.4 Chromium deficiency
0.291 0.709 0.000
E61.3 Manganese deficiency
0.291 0.709 0.000
E61.0 Copper deficiency
0.291 0.709 0.000
G90 Disorders of autonomic nervous system
0.290 0.710 0.000
G24.4 Idiopathic orofacial dystonia
0.290 0.710 0.000
G24.2 Idiopathic nonfamilial dystonia
0.290 0.710 0.000
G24.0 Drug-induced dystonia
0.290 0.710 0.000
G46.7 Other lacunar syndromes
0.289 0.711 0.000
E61.2 Magnesium deficiency
0.288 0.712 0.000
E51.9 Thiamine deficiency, unspecified
0.288 0.712 0.000
E51.8 Other manifestations of thiamine deficiency
0.288 0.712 0.000
E51.1 Beriberi
0.288 0.712 0.000
G57.1 Meralgia paraesthetica
0.288 0.712 0.000
G02.0 Meningitis in viral diseases classified elsewhere
0.285 0.714 0.000
G13.0 Paraneoplastic neuromyopathy and neuropathy
0.279 0.721 0.000
E61.1 Iron deficiency
0.279 0.721 0.000
E23 Hypofunction and other disorders of pituitary gland
0.275 0.724 0.001
E34.5 Androgen resistance syndrome
0.272 0.727 0.000
E34.4 Constitutional tall stature
0.272 0.727 0.000
E34.3 Short stature, not elsewhere classified
0.272 0.727 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.272 0.727 0.000
E34.1 Other hypersecretion of intestinal hormones
0.272 0.727 0.000
G44.4 Drug-induced headache, not elsewhere classified
0.272 0.728 0.000
G44.2 Tension-type headache
0.271 0.729 0.000
G58.9 Mononeuropathy, unspecified
0.270 0.730 0.000
E51.2 Wernicke's encephalopathy
0.268 0.732 0.000
G03.8 Meningitis due to other specified causes
0.268 0.732 0.000
G03.2 Benign recurrent meningitis [Mollaret]
0.268 0.732 0.000
G03.1 Chronic meningitis
0.268 0.732 0.000
G03.0 Nonpyogenic meningitis
0.268 0.732 0.000
G81 Hemiplegia
0.268 0.732 0.000
G00 Bacterial meningitis, not elsewhere classified
0.267 0.733 0.000
G12.2 Motor neuron disease
0.264 0.736 0.000
G90.0 Idiopathic peripheral autonomic neuropathy
0.264 0.736 0.000
G82.3 Flaccid tetraplegia
0.262 0.738 0.000
G82.0 Flaccid paraplegia
0.262 0.738 0.000
G44.3 Chronic posttraumatic headache
0.261 0.738 0.000
G23.8 Other specified degenerative diseases of basal ganglia
0.261 0.739 0.000
G54 Nerve root and plexus disorders
0.260 0.740 0.000
G30.8 Other Alzheimer's disease
0.259 0.740 0.000
G53.0 Postzoster neuralgia
0.259 0.741 0.000
G13.8 Systemic atrophy primarily affecting central nervous system in other diseases classified elsewhere
0.257 0.743 0.000
G13.2 Systemic atrophy primarily affecting central nervous system in myxoedema
0.257 0.743 0.000
G13.1 Other systemic atrophy primarily affecting central nervous system in neoplastic disease
0.257 0.743 0.000
G82.2 Paraplegia, unspecified
0.256 0.744 0.000
G90.2 Horner's syndrome
0.255 0.745 0.000
G02.8 Meningitis in other specified infectious and parasitic diseases classified elsewhere
0.254 0.746 0.000
G02.1 Meningitis in mycoses
0.254 0.746 0.000
G11 Hereditary ataxia
0.251 0.749 0.000
G24.8 Other dystonia
0.251 0.749 0.000
G12.9 Spinal muscular atrophy, unspecified
0.251 0.749 0.000
G12.8 Other spinal muscular atrophies and related syndromes
0.251 0.749 0.000
G12.1 Other inherited spinal muscular atrophy
0.251 0.749 0.000
G12.0 Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]
0.251 0.749 0.000
G23.9 Degenerative disease of basal ganglia, unspecified
0.250 0.750 0.000
G23.3 Multiple system atrophy, cerebellar type
0.250 0.750 0.000
G23.2 Striatonigral degeneration
0.250 0.750 0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
0.250 0.750 0.000
G23.0 Hallervorden-Spatz disease
0.250 0.750 0.000
G04.9 Encephalitis, myelitis and encephalomyelitis, unspecified
0.249 0.751 0.000
G08 Intracranial and intraspinal phlebitis and thrombophlebitis
0.244 0.756 0.000
E34.8 Other specified endocrine disorders
0.242 0.757 0.001
G21.9 Secondary Parkinsonism, unspecified
0.242 0.757 0.000
G21.8 Other secondary Parkinsonism
0.242 0.757 0.000
G21.4 Vascular parkinsonism
0.242 0.757 0.000
G21.3 Postencephalitic Parkinsonism
0.242 0.757 0.000
G21.2 Secondary Parkinsonism due to other external agents
0.242 0.757 0.000
G21.1 Other drug-induced secondary Parkinsonism
0.242 0.757 0.000
G21.0 Malignant neuroleptic syndrome
0.242 0.757 0.000
G92 Toxic encephalopathy
0.242 0.758 0.000
E53.1 Pyridoxine deficiency
0.240 0.760 0.000
E53.0 Riboflavin deficiency
0.240 0.760 0.000
G82.4 Spastic tetraplegia
0.239 0.761 0.000
G04.0 Acute disseminated encephalitis
0.237 0.763 0.000
G04.2 Bacterial meningoencephalitis and meningomyelitis, not elsewhere classified
0.236 0.764 0.000
G04.1 Tropical spastic paraplegia
0.236 0.764 0.000
G05.1 Encephalitis, myelitis and encephalomyelitis in viral diseases classified elsewhere
0.232 0.768 0.000
G05.8 Encephalitis, myelitis and encephalomyelitis in other diseases classified elsewhere
0.232 0.768 0.000
G05.2 Encephalitis, myelitis and encephalomyelitis in other infectious and parasitic diseases classified elsewhere
0.232 0.768 0.000
G05.0 Encephalitis, myelitis and encephalomyelitis in bacterial diseases classified elsewhere
0.232 0.768 0.000
G25 Other extrapyramidal and movement disorders
0.231 0.769 0.000
G60.0 Hereditary motor and sensory neuropathy
0.231 0.769 0.000
G04.8 Other encephalitis, myelitis and encephalomyelitis
0.228 0.772 0.000
E55.0 Rickets, active
0.227 0.772 0.000
G20 Parkinson's disease
0.225 0.775 0.000
G96 Other disorders of central nervous system
0.224 0.776 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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