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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs1686497
log Bayes Factor = 6.72908
Chromosome 2   position 10,961,184  (GRCh37) Explore rs1686497 on Ensembl!
Variant rs1686497 is part of Cluster X0179

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E11 Non-insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E11.9 Without complications
1.000 0.000 0.000
E14 Unspecified diabetes mellitus
0.996 0.004 0.000
E10.5 With peripheral circulatory complications
0.995 0.005 0.000
E10.3 With ophthalmic complications
0.964 0.036 0.000
E10.9 Without complications
0.962 0.038 0.000
E14.9 Without complications
0.954 0.046 0.000
E11.5 With peripheral circulatory complications
0.942 0.058 0.000
E11.1 With ketoacidosis
0.941 0.059 0.000
E10.2 With renal complications
0.928 0.072 0.000
E14.6 With other specified complications
0.919 0.081 0.000
E10.1 With ketoacidosis
0.919 0.081 0.000
E14.3 With ophthalmic complications
0.899 0.101 0.000
E11.0 With coma
0.863 0.137 0.000
E14.5 With peripheral circulatory complications
0.826 0.174 0.000
E11.6 With other specified complications
0.809 0.191 0.000
E11.2 With renal complications
0.806 0.194 0.000
E10.6 With other specified complications
0.775 0.225 0.000
E10.7 With multiple complications
0.753 0.247 0.000
E10.4 With neurological complications
0.723 0.277 0.000
E14.1 With ketoacidosis
0.721 0.279 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E11.7 With multiple complications
0.717 0.283 0.000
E14.4 With neurological complications
0.716 0.284 0.000
E14.7 With multiple complications
0.714 0.285 0.000
E14.0 With coma
0.714 0.285 0.000
E14.2 Withrenal complications
0.710 0.290 0.000
E14.8 With unspecified complications
0.700 0.300 0.000
E10.0 With coma
0.689 0.311 0.000
E13 Other specified diabetes mellitus
0.687 0.313 0.000
E10.8 With unspecified complications
0.596 0.404 0.000
E11.4 With neurological complications
0.572 0.428 0.000
E13.3 With ophthalmic complications
0.541 0.459 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
E13.8 With unspecified complications
0.492 0.507 0.000
E13.7 With multiple complications
0.492 0.507 0.000
E13.6 With other specified complications
0.492 0.507 0.000
E13.5 With peripheral circulatory complications
0.492 0.507 0.000
E13.4 With neurological complications
0.492 0.507 0.000
E13.2 With renal complications
0.492 0.507 0.000
E13.1 With ketoacidosis
0.492 0.507 0.000
E13.0 With coma
0.492 0.507 0.000
E11.3 With ophthalmic complications
0.474 0.526 0.000
E11.8 With unspecified complications
0.444 0.555 0.001
E13.9 Without complications
0.387 0.613 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.061 0.939 0.000
E65-E68 Obesity and other hyperalimentation
0.049 0.951 0.000
E66 Obesity
0.046 0.954 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.045 0.955 0.000
E66.8 Other obesity
0.044 0.956 0.000
E34 Other endocrine disorders
0.040 0.960 0.000
E40-E46 Malnutrition
0.039 0.960 0.000
E34.9 Endocrine disorder, unspecified
0.039 0.961 0.000
E20-E35 Disorders of other endocrine glands
0.039 0.961 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.038 0.962 0.000
E50-E64 Other nutritional deficiencies
0.037 0.963 0.000
E34.0 Carcinoid syndrome
0.036 0.964 0.000
E67 Other hyperalimentation
0.035 0.964 0.000
E68 Sequelae of hyperalimentation
0.035 0.964 0.000
E16 Other disorders of pancreatic internal secretion
0.034 0.966 0.000
E66.1 Drug-induced obesity
0.033 0.967 0.000
E15 Nondiabetic hypoglycaemic coma
0.033 0.967 0.000
E25 Adrenogenital disorders
0.032 0.968 0.000
E26 Hyperaldosteronism
0.030 0.970 0.000
E34.8 Other specified endocrine disorders
0.030 0.970 0.000
E61 Deficiency of other nutrient elements
0.030 0.970 0.000
E56 Other vitamin deficiencies
0.029 0.971 0.000
E66.0 Obesity due to excess calories
0.029 0.971 0.000
E34.5 Androgen resistance syndrome
0.029 0.971 0.000
E34.4 Constitutional tall stature
0.029 0.971 0.000
E34.3 Short stature, not elsewhere classified
0.029 0.971 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.029 0.971 0.000
E34.1 Other hypersecretion of intestinal hormones
0.029 0.971 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.028 0.971 0.000
E45 Retarded development following protein-energy malnutrition
0.028 0.971 0.000
E43 Unspecified severe protein-energy malnutrition
0.028 0.971 0.000
E42 Marasmic kwashiorkor
0.028 0.971 0.000
E41 Nutritional marasmus
0.028 0.971 0.000
E40 Kwashiorkor
0.028 0.971 0.000
E16.2 Hypoglycaemia, unspecified
0.028 0.972 0.000
E58 Dietary calcium deficiency
0.028 0.972 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.028 0.972 0.000
E32 Diseases of thymus
0.028 0.972 0.000
E30 Disorders of puberty, not elsewhere classified
0.028 0.972 0.000
E66.9 Obesity, unspecified
0.028 0.972 0.000
E31 Polyglandular dysfunction
0.027 0.973 0.000
E28 Ovarian dysfunction
0.027 0.973 0.000
E64 Sequelae of malnutrition and other nutritional deficiencies
0.027 0.973 0.000
E63 Other nutritional deficiencies
0.027 0.973 0.000
E50 Vitamin A deficiency
0.027 0.973 0.000
E60 Dietary zinc deficiency
0.027 0.973 0.000
E59 Dietary selenium deficiency
0.027 0.973 0.000
E54 Ascorbic acid deficiency
0.027 0.973 0.000
E52 Niacin deficiency [pellagra]
0.027 0.973 0.000
E20 Hypoparathyroidism
0.027 0.973 0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.027 0.973 0.000
E67.8 Other specified hyperalimentation
0.025 0.974 0.000
E67.3 Hypervitaminosis D
0.025 0.974 0.000
E67.2 Megavitamin-B6 syndrome
0.025 0.974 0.000
E67.1 Hypercarotenaemia
0.025 0.974 0.000
E67.0 Hypervitaminosis A
0.025 0.974 0.000
E23 Hypofunction and other disorders of pituitary gland
0.025 0.974 0.000
E51 Thiamine deficiency
0.025 0.975 0.000
E61.1 Iron deficiency
0.025 0.975 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.025 0.975 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.025 0.975 0.000
E16.4 Abnormal secretion of gastrin
0.025 0.975 0.000
E16.3 Increased secretion of glucagon
0.025 0.975 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.025 0.975 0.000
E22 Hyperfunction of pituitary gland
0.025 0.975 0.000
E46 Unspecified protein-energy malnutrition
0.024 0.976 0.000
E56.1 Deficiency of vitamin K
0.023 0.977 0.000
E26.9 Hyperaldosteronism, unspecified
0.023 0.977 0.000
E26.0 Primary hyperaldosteronism
0.023 0.977 0.000
E25.9 Adrenogenital disorder, unspecified
0.023 0.977 0.000
E25.8 Other adrenogenital disorders
0.023 0.977 0.000
E55 Vitamin D deficiency
0.023 0.977 0.000
E29 Testicular dysfunction
0.022 0.978 0.000
E26.8 Other hyperaldosteronism
0.022 0.978 0.000
E26.1 Secondary hyperaldosteronism
0.022 0.978 0.000
E16.1 Other hypoglycaemia
0.022 0.978 0.000
E61.9 Deficiency of nutrient element, unspecified
0.021 0.978 0.000
E61.8 Deficiency of other specified nutrient elements
0.021 0.978 0.000
E61.7 Deficiency of multiple nutrient elements
0.021 0.978 0.000
E61.6 Vanadium deficiency
0.021 0.978 0.000
E61.5 Molybdenum deficiency
0.021 0.978 0.000
E61.4 Chromium deficiency
0.021 0.978 0.000
E61.3 Manganese deficiency
0.021 0.978 0.000
E61.0 Copper deficiency
0.021 0.978 0.000
E23.6 Other disorders of pituitary gland
0.021 0.978 0.000
E56.9 Vitamin deficiency, unspecified
0.021 0.979 0.000
E56.8 Deficiency of other vitamins
0.021 0.979 0.000
E56.0 Deficiency of vitamin E
0.021 0.979 0.000
E44.1 Mild protein-energy malnutrition
0.021 0.979 0.000
E44.0 Moderate protein-energy malnutrition
0.021 0.979 0.000
E61.2 Magnesium deficiency
0.021 0.979 0.000
S81.9 Open wound of lower leg, part unspecified
0.020 0.980 0.000
E30.9 Disorder of puberty, unspecified
0.020 0.980 0.000
E30.8 Other disorders of puberty
0.020 0.980 0.000
E30.1 Precocious puberty
0.020 0.980 0.000
E30.0 Delayed puberty
0.020 0.980 0.000
E32.9 Disease of thymus, unspecified
0.020 0.980 0.000
E32.8 Other diseases of thymus
0.020 0.980 0.000
E32.1 Abscess of thymus
0.020 0.980 0.000
E32.0 Persistent hyperplasia of thymus
0.020 0.980 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.020 0.980 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.020 0.980 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.020 0.980 0.000
E23.2 Diabetes insipidus
0.020 0.980 0.000
E31.9 Polyglandular dysfunction, unspecified
0.020 0.980 0.000
E31.8 Other polyglandular dysfunction
0.020 0.980 0.000
E31.1 Polyglandular hyperfunction
0.020 0.980 0.000
E28.9 Ovarian dysfunction, unspecified
0.020 0.980 0.000
E28.8 Other ovarian dysfunction
0.020 0.980 0.000
E28.1 Androgen excess
0.020 0.980 0.000
E28.0 Oestrogen excess
0.020 0.980 0.000
S81 Open wound of lower leg
0.020 0.980 0.000
E65 Localised adiposity
0.019 0.980 0.000
E50.9 Vitamin A deficiency, unspecified
0.019 0.980 0.000
E50.8 Other manifestations of vitamin A deficiency
0.019 0.980 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.019 0.980 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.019 0.980 0.000
E50.5 Vitamin A deficiency with night blindness
0.019 0.980 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.019 0.980 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.019 0.980 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.019 0.980 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.019 0.980 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.019 0.980 0.000
E63.9 Nutritional deficiency, unspecified
0.019 0.980 0.000
E63.8 Other specified nutritional deficiencies
0.019 0.980 0.000
E63.1 Imbalance of constituents of food intake
0.019 0.980 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.019 0.980 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.019 0.980 0.000
E64.8 Sequelae of other nutritional deficiencies
0.019 0.980 0.000
E64.3 Sequelae of rickets
0.019 0.980 0.000
E64.2 Sequelae of vitamin C deficiency
0.019 0.980 0.000
E64.1 Sequelae of vitamin A deficiency
0.019 0.980 0.000
E64.0 Sequelae of protein-energy malnutrition
0.019 0.980 0.000
E20.8 Other hypoparathyroidism
0.019 0.981 0.000
E20.1 Pseudohypoparathyroidism
0.019 0.981 0.000
E20.0 Idiopathic hypoparathyroidism
0.019 0.981 0.000
E70-E90 Metabolic disorders
0.019 0.981 0.000
E22.9 Hyperfunction of pituitary gland, unspecified
0.019 0.981 0.000
E28.2 Polycystic ovarian syndrome
0.019 0.981 0.000
E28.3 Primary ovarian failure
0.019 0.981 0.000
E31.0 Autoimmune polyglandular failure
0.019 0.981 0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.018 0.981 0.000
E23.1 Drug-induced hypopituitarism
0.018 0.981 0.000
E22.0 Acromegaly and pituitary gigantism
0.018 0.981 0.000
S81.8 Open wound of other parts of lower leg
0.018 0.982 0.000
E51.9 Thiamine deficiency, unspecified
0.018 0.982 0.000
E51.8 Other manifestations of thiamine deficiency
0.018 0.982 0.000
E51.1 Beriberi
0.018 0.982 0.000
E20.9 Hypoparathyroidism, unspecified
0.018 0.982 0.000
E22.8 Other hyperfunction of pituitary gland
0.018 0.982 0.000
E22.1 Hyperprolactinaemia
0.018 0.982 0.000
S81.7 Multiple open wounds of lower leg
0.017 0.982 0.000
D61.9 Aplastic anaemia, unspecified
0.000 0.983 0.017
E83.1 Disorders of iron metabolism
0.017 0.983 0.000
E74 Other disorders of carbohydrate metabolism
0.017 0.983 0.000
E83 Disorders of mineral metabolism
0.017 0.983 0.000
E55.0 Rickets, active
0.017 0.983 0.000
E51.2 Wernicke's encephalopathy
0.016 0.983 0.000
E29.9 Testicular dysfunction, unspecified
0.016 0.984 0.000
E29.8 Other testicular dysfunction
0.016 0.984 0.000
E29.0 Testicular hyperfunction
0.016 0.984 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.016 0.984 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.016 0.984 0.000
E53 Deficiency of other B group vitamins
0.016 0.984 0.000
K20 Oesophagitis
0.016 0.984 0.000
E74.3 Other disorders of intestinal carbohydrate absorption
0.016 0.984 0.000
S80-S89 Injuries to the knee and lower leg
0.015 0.985 0.000
E84 Cystic fibrosis
0.015 0.985 0.000
E73 Lactose intolerance
0.015 0.985 0.000
E24 Cushing's syndrome
0.014 0.985 0.000
E85 Amyloidosis
0.014 0.986 0.000
E72 Other disorders of amino-acid metabolism
0.014 0.986 0.000
E27 Other disorders of adrenal gland
0.014 0.986 0.000
E23.0 Hypopituitarism
0.014 0.986 0.000
E77 Disorders of glycoprotein metabolism
0.014 0.986 0.000
E76 Disorders of glycosaminoglycan metabolism
0.014 0.986 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.014 0.986 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.014 0.986 0.000
E79 Disorders of purine and pyrimidine metabolism
0.014 0.986 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.014 0.986 0.000
S86 Injury of muscle and tendon at lower leg level
0.014 0.986 0.000
E70 Disorders of aromatic amino-acid metabolism
0.014 0.986 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.014 0.986 0.000
E75.2 Other sphingolipidosis
0.014 0.986 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.013 0.987 0.000
E21.0 Primary hyperparathyroidism
0.013 0.987 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.013 0.987 0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee
0.013 0.987 0.000
E55.9 Vitamin D deficiency, unspecified
0.013 0.987 0.000
E74.9 Disorder of carbohydrate metabolism, unspecified
0.012 0.987 0.000
E74.8 Other specified disorders of carbohydrate metabolism
0.012 0.987 0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.012 0.987 0.000
E74.2 Disorders of galactose metabolism
0.012 0.987 0.000
E74.1 Disorders of fructose metabolism
0.012 0.987 0.000
E74.0 Glycogen storage disease
0.012 0.987 0.000
M80 Osteoporosis with pathological fracture
0.013 0.987 0.000
E83.9 Disorder of mineral metabolism, unspecified
0.012 0.988 0.000
E83.8 Other disorders of mineral metabolism
0.012 0.988 0.000
E83.2 Disorders of zinc metabolism
0.012 0.988 0.000
E83.0 Disorders of copper metabolism
0.012 0.988 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.012 0.988 0.000
E23.7 Disorder of pituitary gland, unspecified
0.012 0.988 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.012 0.988 0.000
E85.4 Organ-limited amyloidosis
0.012 0.988 0.000
S87 Crushing injury of lower leg
0.012 0.988 0.000
E83.4 Disorders of magnesium metabolism
0.012 0.988 0.000
S82.1 Fracture of upper end of tibia
0.012 0.988 0.000
S82.10 Fracture of upper end of tibia (closed)
0.012 0.988 0.000
E27.2 Addisonian crisis
0.012 0.988 0.000
S82 Fracture of lower leg, including ankle
0.012 0.988 0.000
E78.4 Other hyperlipidaemia
0.012 0.988 0.000
E21.4 Other specified disorders of parathyroid gland
0.012 0.988 0.000
M80.8 Other osteoporosis with pathological fracture
0.012 0.988 0.000
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level
0.012 0.988 0.000
S84 Injury of nerves at lower leg level
0.012 0.988 0.000
E75.6 Lipid storage disorder, unspecified
0.012 0.988 0.000
E75.4 Neuronal ceroid lipofuscinosis
0.012 0.988 0.000
E75.3 Sphingolipidosis, unspecified
0.012 0.988 0.000
E75.1 Other gangliosidosis
0.012 0.988 0.000
E75.0 GM2 gangliosidosis
0.012 0.988 0.000
E84.9 Cystic fibrosis, unspecified
0.011 0.988 0.000
E21.2 Other hyperparathyroidism
0.011 0.988 0.000
E53.1 Pyridoxine deficiency
0.011 0.988 0.000
E53.0 Riboflavin deficiency
0.011 0.988 0.000
M80.98 Unspecified osteoporosis with pathological fracture (Other)
0.012 0.988 0.000
E73.9 Lactose intolerance, unspecified
0.011 0.989 0.000
R02 Gangrene, not elsewhere classified
0.011 0.989 0.000
E75.5 Other lipid storage disorders
0.011 0.989 0.000
M80.88 Other osteoporosis with pathological fracture (Other)
0.011 0.989 0.000
S88 Traumatic amputation of lower leg
0.011 0.989 0.000
S85 Injury of blood vessels at lower leg level
0.011 0.989 0.000
S83.7 Injury to multiple structures of knee
0.011 0.989 0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level
0.011 0.989 0.000
E84.8 Cystic fibrosis with other manifestations
0.011 0.989 0.000
E84.1 Cystic fibrosis with intestinal manifestations
0.011 0.989 0.000
E84.0 Cystic fibrosis with pulmonary manifestations
0.011 0.989 0.000
M80.90 Unspecified osteoporosis with pathological fracture (Multiple sites)
0.011 0.989 0.000
E72.0 Disorders of amino-acid transport
0.011 0.989 0.000
E78.0 Pure hypercholesterolaemia
0.011 0.989 0.000
E73.8 Other lactose intolerance
0.011 0.989 0.000
E73.1 Secondary lactase deficiency
0.011 0.989 0.000
E73.0 Congenital lactase deficiency
0.011 0.989 0.000
S82.3 Fracture of lower end of tibia
0.011 0.989 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.010 0.989 0.000
E24.3 Ectopic ACTH syndrome
0.010 0.989 0.000
E24.1 Nelson's syndrome
0.010 0.989 0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture
0.011 0.989 0.000
S86.8 Injury of other muscles and tendons at lower leg level
0.011 0.989 0.000
E72.9 Disorder of amino-acid metabolism, unspecified
0.010 0.989 0.000
E72.8 Other specified disorders of amino-acid metabolism
0.010 0.989 0.000
E72.5 Disorders of glycine metabolism
0.010 0.989 0.000
E72.4 Disorders of ornithine metabolism
0.010 0.989 0.000
E72.3 Disorders of lysine and hydroxylysine metabolism
0.010 0.989 0.000
E72.2 Disorders of urea cycle metabolism
0.010 0.989 0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.010 0.989 0.000
E85.2 Heredofamilial amyloidosis, unspecified
0.010 0.989 0.000
E85.1 Neuropathic heredofamilial amyloidosis
0.010 0.989 0.000
E85.0 Nonneuropathic heredofamilial amyloidosis
0.010 0.989 0.000
E85.8 Other amyloidosis
0.010 0.989 0.000
E27.5 Adrenomedullary hyperfunction
0.010 0.989 0.000
E27.0 Other adrenocortical overactivity
0.010 0.989 0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level
0.010 0.989 0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level
0.010 0.989 0.000
S80 Superficial injury of lower leg
0.011 0.989 0.000
E24.8 Other Cushing's syndrome
0.010 0.989 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.010 0.989 0.000
E29.1 Testicular hypofunction
0.010 0.989 0.000
E71.3 Disorders of fatty-acid metabolism
0.010 0.990 0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.010 0.990 0.000
E71.1 Other disorders of branched-chain amino-acid metabolism
0.010 0.990 0.000
E71.0 Maple-syrup-urine disease
0.010 0.990 0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.010 0.990 0.000
E76.8 Other disorders of glucosaminoglycan metabolism
0.010 0.990 0.000
E76.3 Mucopolysaccharidosis, unspecified
0.010 0.990 0.000
E76.2 Other mucopolysaccharidoses
0.010 0.990 0.000
E76.1 Mucopolysaccharidosis, type II
0.010 0.990 0.000
E76.0 Mucopolysaccharidosis, type I
0.010 0.990 0.000
E77.9 Disorder of glycoprotein metabolism, unspecified
0.010 0.990 0.000
E77.8 Other disorders of glycoprotein metabolism
0.010 0.990 0.000
E77.1 Defects in glycoprotein degradation
0.010 0.990 0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.010 0.990 0.000
S82.30 Fracture of lower end of tibia (closed)
0.010 0.990 0.000
S81.0 Open wound of knee
0.010 0.990 0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.010 0.990 0.000
E79.8 Other disorders of purine and pyrimidine metabolism
0.010 0.990 0.000
E79.1 Lesch-Nyhan syndrome
0.010 0.990 0.000
S83.1 Dislocation of knee
0.010 0.990 0.000
S83.0 Dislocation of patella
0.010 0.990 0.000
E89.0 Postprocedural hypothyroidism
0.010 0.990 0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.010 0.990 0.000
E70.8 Other disorders of aromatic amino-acid metabolism
0.010 0.990 0.000
E70.2 Disorders of tyrosine metabolism
0.010 0.990 0.000
E70.1 Other hyperphenylalaninaemias
0.010 0.990 0.000
E70.0 Classical phenylketonuria
0.010 0.990 0.000
S86.0 Injury of Achilles tendon
0.010 0.990 0.000
S86.7 Injury of multiple muscles and tendons at lower leg level
0.010 0.990 0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.010 0.990 0.000
M80.5 Idiopathic osteoporosis with pathological fracture
0.010 0.990 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.010 0.990 0.000
E83.3 Disorders of phosphorus metabolism
0.010 0.990 0.000
E70.3 Albinism
0.010 0.990 0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.010 0.990 0.000
E78.3 Hyperchylomicronaemia
0.010 0.990 0.000
E85.9 Amyloidosis, unspecified
0.010 0.990 0.000
S82.11 Fracture of upper end of tibia (open)
0.010 0.990 0.000
E27.8 Other specified disorders of adrenal gland
0.010 0.990 0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)
0.010 0.990 0.000
E85.3 Secondary systemic amyloidosis
0.010 0.990 0.000
S87.8 Crushing injury of other and unspecified parts of lower leg
0.010 0.990 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.009 0.990 0.000
E78.8 Other disorders of lipoprotein metabolism
0.010 0.990 0.000
M81.40 Drug-induced osteoporosis (Multiple sites)
0.010 0.990 0.000
E89.2 Postprocedural hypoparathyroidism
0.009 0.990 0.000
M81.4 Drug-induced osteoporosis
0.010 0.990 0.000
M81 Osteoporosis without pathological fracture
0.010 0.990 0.000
E83.5 Disorders of calcium metabolism
0.010 0.990 0.000
S83.3 Tear of articular cartilage of knee, current
0.009 0.991 0.000
S80.7 Multiple superficial injuries of lower leg
0.009 0.991 0.000
E89.1 Postprocedural hypoinsulinaemia
0.009 0.991 0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)
0.009 0.991 0.000
E78.6 Lipoprotein deficiency
0.009 0.991 0.000
M80-M85 Disorders of bone density and structure
0.009 0.991 0.000
E27.1 Primary adrenocortical insufficiency
0.009 0.991 0.000
M80.4 Drug-induced osteoporosis with pathological fracture
0.009 0.991 0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture
0.009 0.991 0.000
M80.2 Osteoporosis of disuse with pathological fracture
0.009 0.991 0.000
M80.97 Unspecified osteoporosis with pathological fracture (Ankle and foot)
0.009 0.991 0.000
M80.96 Unspecified osteoporosis with pathological fracture (Lower leg)
0.009 0.991 0.000
M80.94 Unspecified osteoporosis with pathological fracture (Hand)
0.009 0.991 0.000
M80.93 Unspecified osteoporosis with pathological fracture (Forearm)
0.009 0.991 0.000
M80.92 Unspecified osteoporosis with pathological fracture (Upper arm)
0.009 0.991 0.000
M80.91 Unspecified osteoporosis with pathological fracture (Shoulder region)
0.009 0.991 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.009 0.991 0.000
S84.1 Injury of peroneal nerve at lower leg level
0.009 0.991 0.000
E24.0 Pituitary-dependent Cushing's disease
0.009 0.991 0.001
M80.81 Other osteoporosis with pathological fracture (Shoulder region)
0.009 0.991 0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.009 0.991 0.000
E89.8 Other postprocedural endocrine and metabolic disorders
0.009 0.991 0.000
E89.5 Postprocedural testicular hypofunction
0.009 0.991 0.000
M80.0 Postmenopausal osteoporosis with pathological fracture
0.009 0.991 0.000
S82.6 Fracture of lateral malleolus
0.009 0.991 0.000
E24.2 Drug-induced Cushing's syndrome
0.008 0.991 0.001
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)
0.009 0.991 0.000
S87.0 Crushing injury of knee
0.009 0.991 0.000
E53.9 Vitamin B deficiency, unspecified
0.009 0.991 0.000
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)
0.009 0.991 0.000
E88 Other metabolic disorders
0.009 0.991 0.000
M80.89 Other osteoporosis with pathological fracture (Site unspecified)
0.009 0.991 0.000
M80.87 Other osteoporosis with pathological fracture (Ankle and foot)
0.009 0.991 0.000
M80.86 Other osteoporosis with pathological fracture (Lower leg)
0.009 0.991 0.000
M80.85 Other osteoporosis with pathological fracture (Pelvic region and thigh)
0.009 0.991 0.000
M80.84 Other osteoporosis with pathological fracture (Hand)
0.009 0.991 0.000
M80.83 Other osteoporosis with pathological fracture (Forearm)
0.009 0.991 0.000
M80.82 Other osteoporosis with pathological fracture (Upper arm)
0.009 0.991 0.000
M80.80 Other osteoporosis with pathological fracture (Multiple sites)
0.009 0.991 0.000
S84.9 Injury of unspecified nerve at lower leg level
0.008 0.991 0.000
S84.8 Injury of other nerves at lower leg level
0.008 0.991 0.000
S84.7 Injury of multiple nerves at lower leg level
0.008 0.991 0.000
S84.2 Injury of cutaneous sensory nerve at lower leg level
0.008 0.991 0.000
S84.0 Injury of tibial nerve at lower leg level
0.008 0.991 0.000
S83.6 Sprain and strain of other and unspecified parts of knee
0.008 0.991 0.000
E89.4 Postprocedural ovarian failure
0.008 0.992 0.000
S80.8 Other superficial injuries of lower leg
0.008 0.992 0.000
S85.9 Injury of unspecified blood vessel at lower leg level
0.008 0.992 0.000
S85.8 Injury of other blood vessels at lower leg level
0.008 0.992 0.000
S85.7 Injury of multiple blood vessels at lower leg level
0.008 0.992 0.000
S85.5 Injury of popliteal vein
0.008 0.992 0.000
S85.4 Injury of lesser saphenous vein at lower leg level
0.008 0.992 0.000
S85.3 Injury of greater saphenous vein at lower leg level
0.008 0.992 0.000
S85.2 Injury of peroneal artery
0.008 0.992 0.000
S85.1 Injury of (anterior)(posterior) tibial artery
0.008 0.992 0.000
S85.0 Injury of popliteal artery
0.008 0.992 0.000
S88.9 Traumatic amputation of lower leg, level unspecified
0.008 0.992 0.000
S88.1 Traumatic amputation at level between knee and ankle
0.008 0.992 0.000
S88.0 Traumatic amputation at knee level
0.008 0.992 0.000
M84.4 Pathological fracture, not elsewhere classified
0.008 0.992 0.000
S82.4 Fracture of fibula alone
0.008 0.992 0.000
S89 Other and unspecified injuries of lower leg
0.008 0.992 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.008 0.992 0.000
S82.2 Fracture of shaft of tibia
0.008 0.992 0.000
S82.8 Fractures of other parts of lower leg
0.008 0.992 0.000
S82.9 Fracture of lower leg, part unspecified
0.008 0.992 0.000
M83 Adult osteomalacia
0.008 0.992 0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)
0.008 0.992 0.000
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)
0.008 0.992 0.000
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)
0.008 0.992 0.000
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)
0.008 0.992 0.000
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)
0.008 0.992 0.000
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)
0.008 0.992 0.000
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)
0.008 0.992 0.000
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)
0.008 0.992 0.000
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)
0.008 0.992 0.000
M84.42 Pathological fracture, not elsewhere classified (Upper arm)
0.008 0.992 0.000
M81.49 Drug-induced osteoporosis (Site unspecified)
0.008 0.992 0.000
M81.90 Osteoporosis, unspecified (Multiple sites)
0.008 0.992 0.000
S80.9 Superficial injury of lower leg, unspecified
0.008 0.992 0.000
S86.00 Unspecified injury of Achilles tendon
0.007 0.992 0.000
M84 Disorders of continuity of bone
0.008 0.992 0.000
M81.8 Other osteoporosis
0.007 0.992 0.000
M81.2 Osteoporosis of disuse
0.007 0.992 0.000
M80.59 Idiopathic osteoporosis with pathological fracture (Site unspecified)
0.007 0.992 0.000
M80.58 Idiopathic osteoporosis with pathological fracture (Other)
0.007 0.992 0.000
M80.57 Idiopathic osteoporosis with pathological fracture (Ankle and foot)
0.007 0.992 0.000
M80.56 Idiopathic osteoporosis with pathological fracture (Lower leg)
0.007 0.992 0.000
M80.55 Idiopathic osteoporosis with pathological fracture (Pelvic region and thigh)
0.007 0.992 0.000
M80.54 Idiopathic osteoporosis with pathological fracture (Hand)
0.007 0.992 0.000
M80.53 Idiopathic osteoporosis with pathological fracture (Forearm)
0.007 0.992 0.000
M80.51 Idiopathic osteoporosis with pathological fracture (Shoulder region)
0.007 0.992 0.000
E78.1 Pure hyperglyceridaemia
0.007 0.992 0.000
M84.48 Pathological fracture, not elsewhere classified (Other)
0.007 0.993 0.000
S82.31 Fracture of lower end of tibia (open)
0.007 0.993 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.007 0.993 0.000
S82.7 Multiple fractures of lower leg
0.007 0.993 0.000
S82.5 Fracture of medial malleolus
0.007 0.993 0.000
E80.1 Porphyria cutanea tarda
0.007 0.993 0.000
M81.48 Drug-induced osteoporosis (Other)
0.007 0.993 0.000
M81.47 Drug-induced osteoporosis (Ankle and foot)
0.007 0.993 0.000
M81.46 Drug-induced osteoporosis (Lower leg)
0.007 0.993 0.000
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)
0.007 0.993 0.000
M81.44 Drug-induced osteoporosis (Hand)
0.007 0.993 0.000
M81.43 Drug-induced osteoporosis (Forearm)
0.007 0.993 0.000
M81.42 Drug-induced osteoporosis (Upper arm)
0.007 0.993 0.000
M81.41 Drug-induced osteoporosis (Shoulder region)
0.007 0.993 0.000
M81.6 Localised osteoporosis [Lequesne]
0.007 0.993 0.000
M81.5 Idiopathic osteoporosis
0.007 0.993 0.000
M81.3 Postsurgical malabsorption osteoporosis
0.007 0.993 0.000
M81.1 Postoophorectomy osteoporosis
0.007 0.993 0.000
M81.9 Osteoporosis, unspecified
0.007 0.993 0.000
M83.1 Senile osteomalacia
0.007 0.993 0.000
S82.61 Fracture of lateral malleolus (open)
0.007 0.993 0.000
E88.2 Lipomatosis, not elsewhere classified
0.007 0.993 0.000
M80.29 Osteoporosis of disuse with pathological fracture (Site unspecified)
0.007 0.993 0.000
M80.28 Osteoporosis of disuse with pathological fracture (Other)
0.007 0.993 0.000
M80.27 Osteoporosis of disuse with pathological fracture (Ankle and foot)
0.007 0.993 0.000
M80.26 Osteoporosis of disuse with pathological fracture (Lower leg)
0.007 0.993 0.000
M80.25 Osteoporosis of disuse with pathological fracture (Pelvic region and thigh)
0.007 0.993 0.000
M80.24 Osteoporosis of disuse with pathological fracture (Hand)
0.007 0.993 0.000
M80.23 Osteoporosis of disuse with pathological fracture (Forearm)
0.007 0.993 0.000
M80.22 Osteoporosis of disuse with pathological fracture (Upper arm)
0.007 0.993 0.000
M80.21 Osteoporosis of disuse with pathological fracture (Shoulder region)
0.007 0.993 0.000
M80.20 Osteoporosis of disuse with pathological fracture (Multiple sites)
0.007 0.993 0.000
M80.39 Postsurgical malabsorption osteoporosis with pathological fracture (Site unspecified)
0.007 0.993 0.000
M80.38 Postsurgical malabsorption osteoporosis with pathological fracture (Other)
0.007 0.993 0.000
M80.37 Postsurgical malabsorption osteoporosis with pathological fracture (Ankle and foot)
0.007 0.993 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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