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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs16897515
log Bayes Factor = 87.0233
Chromosome 6   position 27,278,020  (GRCh37) Explore rs16897515 on Ensembl!
Variant rs16897515 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
1.000 0.000 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
1.000 0.000 0.000
E05.9 Thyrotoxicosis, unspecified
1.000 0.000 0.000
E00-E07 Disorders of thyroid gland
1.000 0.000 0.000
E83.1 Disorders of iron metabolism
0.000 0.000 1.000
E05 Thyrotoxicosis [hyperthyroidism]
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
1.000 0.000 0.000
E10-E14 Diabetes mellitus
1.000 0.000 0.000
E10.9 Without complications
0.999 0.001 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.998 0.002 0.000
E16 Other disorders of pancreatic internal secretion
0.997 0.003 0.000
E20-E35 Disorders of other endocrine glands
0.996 0.004 0.000
E16.2 Hypoglycaemia, unspecified
0.995 0.005 0.000
E27 Other disorders of adrenal gland
0.995 0.005 0.000
E27.1 Primary adrenocortical insufficiency
0.991 0.009 0.000
R31 Unspecified haematuria
0.000 0.014 0.986
E03 Other hypothyroidism
0.985 0.015 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.000 0.020 0.980
T42.4 Benzodiazepines
0.000 0.022 0.978
T36-T50 Poisoning by drugs, medicaments and biological substances
0.000 0.028 0.972
E03.9 Hypothyroidism, unspecified
0.970 0.030 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.000 0.035 0.965
T39.1 4-Aminophenol derivatives
0.000 0.038 0.962
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.000 0.040 0.960
E10.3 With ophthalmic complications
0.960 0.040 0.000
E27.4 Other and unspecified adrenocortical insufficiency
0.960 0.040 0.000
N40 Hyperplasia of prostate
0.000 0.048 0.952
E05.0 Thyrotoxicosis with diffuse goitre
0.911 0.089 0.000
E10.2 With renal complications
0.891 0.109 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.000 0.132 0.868
E24 Cushing's syndrome
0.858 0.142 0.000
E10.1 With ketoacidosis
0.851 0.149 0.000
E13 Other specified diabetes mellitus
0.843 0.157 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.000 0.160 0.840
T39.0 Salicylates
0.000 0.161 0.839
E31 Polyglandular dysfunction
0.836 0.164 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.000 0.165 0.835
E14 Unspecified diabetes mellitus
0.827 0.173 0.000
E20 Hypoparathyroidism
0.808 0.192 0.000
E16.1 Other hypoglycaemia
0.806 0.194 0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.805 0.195 0.000
E50-E64 Other nutritional deficiencies
0.797 0.203 0.000
E27.3 Drug-induced adrenocortical insufficiency
0.794 0.206 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.000 0.207 0.793
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.000 0.210 0.790
E24.2 Drug-induced Cushing's syndrome
0.779 0.221 0.000
E40-E46 Malnutrition
0.776 0.224 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.000 0.238 0.762
D12.0 Caecum
0.000 0.247 0.753
E22 Hyperfunction of pituitary gland
0.749 0.251 0.000
E05.8 Other thyrotoxicosis
0.748 0.252 0.000
D12.2 Ascending colon
0.000 0.254 0.746
E10.5 With peripheral circulatory complications
0.743 0.257 0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal
0.000 0.260 0.740
E27.2 Addisonian crisis
0.739 0.261 0.000
K90 Intestinal malabsorption
0.734 0.266 0.000
E25 Adrenogenital disorders
0.733 0.267 0.000
E13.9 Without complications
0.730 0.270 0.000
E16.0 Drug-induced hypoglycaemia without coma
0.730 0.270 0.000
T42.0 Hydantoin derivatives
0.000 0.277 0.723
E31.0 Autoimmune polyglandular failure
0.721 0.279 0.000
T36 Poisoning by systemic antibiotics
0.000 0.280 0.720
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.717 0.283 0.000
E00 Congenital iodine-deficiency syndrome
0.717 0.283 0.000
E05.5 Thyroid crisis or storm
0.717 0.283 0.000
E05.4 Thyrotoxicosis factitia
0.717 0.283 0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.717 0.283 0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.717 0.283 0.000
E10.7 With multiple complications
0.717 0.283 0.000
E12 Malnutrition-related diabetes mellitus
0.717 0.283 0.000
E10.6 With other specified complications
0.716 0.284 0.000
E15 Nondiabetic hypoglycaemic coma
0.715 0.284 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.714 0.285 0.000
E16.8 Other specified disorders of pancreatic internal secretion
0.714 0.285 0.000
E16.4 Abnormal secretion of gastrin
0.714 0.285 0.000
E16.3 Increased secretion of glucagon
0.714 0.285 0.000
E35 Disorders of endocrine glands in diseases classified elsewhere
0.714 0.285 0.000
E32 Diseases of thymus
0.714 0.285 0.000
E30 Disorders of puberty, not elsewhere classified
0.714 0.285 0.000
E27.5 Adrenomedullary hyperfunction
0.713 0.287 0.000
E27.0 Other adrenocortical overactivity
0.713 0.287 0.000
E24.0 Pituitary-dependent Cushing's disease
0.713 0.287 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.000 0.290 0.710
T42.1 Iminostilbenes
0.000 0.291 0.709
E10.0 With coma
0.707 0.292 0.000
E03.5 Myxoedema coma
0.706 0.294 0.000
E03.4 Atrophy of thyroid (acquired)
0.706 0.294 0.000
E03.3 Postinfectious hypothyroidism
0.706 0.294 0.000
E03.1 Congenital hypothyroidism without goitre
0.706 0.294 0.000
E03.0 Congenital hypothyroidism with diffuse goitre
0.706 0.294 0.000
E34 Other endocrine disorders
0.704 0.296 0.000
E10.8 With unspecified complications
0.703 0.297 0.000
E14.1 With ketoacidosis
0.703 0.297 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.000 0.298 0.702
T42.5 Mixed antiepileptics, not elsewhere classified
0.000 0.298 0.702
T42.3 Barbiturates
0.000 0.298 0.702
T42.2 Succinimides and oxazolidinediones
0.000 0.298 0.702
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.000 0.303 0.697
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.000 0.303 0.697
T41 Poisoning by anaesthetics and therapeutic gases
0.000 0.303 0.697
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.000 0.303 0.697
T40.2 Other opioids
0.000 0.305 0.695
T40.4 Other synthetic narcotics
0.000 0.305 0.695
E14.3 With ophthalmic complications
0.693 0.307 0.000
T39.4 Antirheumatics, not elsewhere classified
0.000 0.308 0.692
T39.2 Pyrazolone derivatives
0.000 0.308 0.692
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.000 0.315 0.685
E03.8 Other specified hypothyroidism
0.674 0.326 0.000
E20.9 Hypoparathyroidism, unspecified
0.673 0.327 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.000 0.328 0.672
E23 Hypofunction and other disorders of pituitary gland
0.672 0.328 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.000 0.329 0.671
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.000 0.332 0.668
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.000 0.338 0.662
E53 Deficiency of other B group vitamins
0.651 0.349 0.000
K90.9 Intestinal malabsorption, unspecified
0.651 0.349 0.000
E29 Testicular dysfunction
0.649 0.351 0.000
E14.2 Withrenal complications
0.648 0.352 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.639 0.360 0.000
E26 Hyperaldosteronism
0.639 0.361 0.000
E07 Other disorders of thyroid
0.639 0.361 0.000
T43.6 Psychostimulants with abuse potential
0.000 0.366 0.634
E10.4 With neurological complications
0.633 0.367 0.000
T50.8 Diagnostic agents
0.000 0.378 0.622
T50.7 Analeptics and opioid receptor antagonists
0.000 0.378 0.622
T50.6 Antidotes and chelating agents, not elsewhere classified
0.000 0.378 0.622
T50.5 Appetite depressants
0.000 0.378 0.622
T50.4 Drugs affecting uric acid metabolism
0.000 0.378 0.622
T50.3 Electrolytic, caloric and water-balance agents
0.000 0.378 0.622
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.000 0.378 0.622
T50.1 Loop [high-ceiling] diuretics
0.000 0.378 0.622
T50.0 Mineralocorticoids and their antagonists
0.000 0.378 0.622
E46 Unspecified protein-energy malnutrition
0.616 0.384 0.000
E24.8 Other Cushing's syndrome
0.615 0.384 0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.615 0.384 0.000
E24.3 Ectopic ACTH syndrome
0.615 0.384 0.000
E24.1 Nelson's syndrome
0.615 0.384 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.611 0.389 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.000 0.392 0.608
E13.8 With unspecified complications
0.604 0.396 0.000
E13.7 With multiple complications
0.604 0.396 0.000
E13.6 With other specified complications
0.604 0.396 0.000
E13.5 With peripheral circulatory complications
0.604 0.396 0.000
E13.4 With neurological complications
0.604 0.396 0.000
E13.3 With ophthalmic complications
0.604 0.396 0.000
E13.2 With renal complications
0.604 0.396 0.000
E13.1 With ketoacidosis
0.604 0.396 0.000
E13.0 With coma
0.604 0.396 0.000
D12.7 Rectosigmoid junction
0.000 0.397 0.603
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.000 0.397 0.603
T40.8 Lysergide [LSD]
0.000 0.397 0.603
T40.7 Cannabis (derivatives)
0.000 0.397 0.603
T40.5 Cocaine
0.000 0.397 0.603
T40.3 Methadone
0.000 0.397 0.603
T40.1 Heroin
0.000 0.397 0.603
T40.0 Opium
0.000 0.397 0.603
E31.9 Polyglandular dysfunction, unspecified
0.599 0.401 0.000
E31.8 Other polyglandular dysfunction
0.599 0.401 0.000
E31.1 Polyglandular hyperfunction
0.599 0.401 0.000
T43.9 Psychotropic drug, unspecified
0.000 0.401 0.599
T43.8 Other psychotropic drugs, not elsewhere classified
0.000 0.401 0.599
E56 Other vitamin deficiencies
0.598 0.401 0.000
E14.5 With peripheral circulatory complications
0.595 0.405 0.000
E14.7 With multiple complications
0.593 0.407 0.000
E14.0 With coma
0.593 0.407 0.000
T40.6 Other and unspecified narcotics
0.000 0.412 0.588
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.586 0.414 0.000
E20.8 Other hypoparathyroidism
0.579 0.420 0.000
E20.1 Pseudohypoparathyroidism
0.579 0.420 0.000
E20.0 Idiopathic hypoparathyroidism
0.579 0.420 0.000
E61 Deficiency of other nutrient elements
0.578 0.422 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.000 0.423 0.577
T43.2 Other and unspecified antidepressants
0.000 0.423 0.577
E14.6 With other specified complications
0.572 0.428 0.000
D12.5 Sigmoid colon
0.000 0.428 0.572
E64 Sequelae of malnutrition and other nutritional deficiencies
0.571 0.429 0.000
E63 Other nutritional deficiencies
0.571 0.429 0.000
E50 Vitamin A deficiency
0.571 0.429 0.000
E60 Dietary zinc deficiency
0.571 0.429 0.000
E59 Dietary selenium deficiency
0.571 0.429 0.000
E58 Dietary calcium deficiency
0.571 0.429 0.000
E54 Ascorbic acid deficiency
0.571 0.429 0.000
E52 Niacin deficiency [pellagra]
0.571 0.429 0.000
E14.8 With unspecified complications
0.569 0.431 0.000
F32.9 Depressive episode, unspecified
0.000 0.435 0.565
E34.9 Endocrine disorder, unspecified
0.562 0.437 0.000
E51 Thiamine deficiency
0.561 0.439 0.000
F32 Depressive episode
0.000 0.441 0.559
D12.1 Appendix
0.000 0.442 0.558
E44 Protein-energy malnutrition of moderate and mild degree
0.557 0.443 0.000
E45 Retarded development following protein-energy malnutrition
0.557 0.443 0.000
E43 Unspecified severe protein-energy malnutrition
0.557 0.443 0.000
E42 Marasmic kwashiorkor
0.557 0.443 0.000
E41 Nutritional marasmus
0.557 0.443 0.000
E40 Kwashiorkor
0.557 0.443 0.000
F30-F39 Mood [affective] disorders
0.000 0.446 0.554
D12.3 Transverse colon
0.000 0.451 0.549
D12.6 Colon, unspecified
0.000 0.452 0.548
E22.1 Hyperprolactinaemia
0.548 0.452 0.000
F33 Recurrent depressive disorder
0.000 0.455 0.545
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.545 0.455 0.000
E53.8 Deficiency of other specified B group vitamins
0.544 0.456 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.000 0.458 0.542
E55 Vitamin D deficiency
0.542 0.458 0.000
T36.0 Penicillins
0.000 0.461 0.539
E22.9 Hyperfunction of pituitary gland, unspecified
0.537 0.463 0.000
E22.8 Other hyperfunction of pituitary gland
0.537 0.463 0.000
F33.9 Recurrent depressive disorder, unspecified
0.000 0.465 0.535
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.000 0.468 0.532
F32.2 Severe depressive episode without psychotic symptoms
0.000 0.471 0.529
K90.8 Other intestinal malabsorption
0.526 0.473 0.000
K90.3 Pancreatic steatorrhoea
0.526 0.473 0.000
K90.2 Blind loop syndrome, not elsewhere classified
0.526 0.473 0.000
K90.1 Tropical sprue
0.526 0.473 0.000
E25.9 Adrenogenital disorder, unspecified
0.526 0.474 0.000
E25.8 Other adrenogenital disorders
0.526 0.474 0.000
E23.7 Disorder of pituitary gland, unspecified
0.523 0.476 0.000
D12.9 Anus and anal canal
0.000 0.481 0.519
T36.9 Systemic antibiotic, unspecified
0.000 0.484 0.516
T36.8 Other systemic antibiotics
0.000 0.484 0.516
T36.7 Antifungal antibiotics, systemically used
0.000 0.484 0.516
T36.6 Rifamycins
0.000 0.484 0.516
T36.5 Aminoglycosides
0.000 0.484 0.516
T36.4 Tetracyclines
0.000 0.484 0.516
T36.3 Macrolides
0.000 0.484 0.516
T36.2 Chloramphenicol group
0.000 0.484 0.516
T36.1 Cefalosporins and other Beta-lactam antibiotics
0.000 0.484 0.516
E14.9 Without complications
0.516 0.484 0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.514 0.486 0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.514 0.486 0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.514 0.486 0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.514 0.486 0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.514 0.486 0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.514 0.486 0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.514 0.486 0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.514 0.486 0.000
E12.9 Without complications
0.514 0.486 0.000
E12.8 With unspecified complications
0.514 0.486 0.000
E12.7 With multiple complications
0.514 0.486 0.000
E12.6 With other specified complications
0.514 0.486 0.000
E12.5 With peripheral circulatory complications
0.514 0.486 0.000
E12.4 With neurological complications
0.514 0.486 0.000
E12.3 With ophthalmic complications
0.514 0.486 0.000
E12.2 With renal complications
0.514 0.486 0.000
E12.1 With ketoacidosis
0.514 0.486 0.000
E12.0 With coma
0.514 0.486 0.000
E30.9 Disorder of puberty, unspecified
0.512 0.488 0.000
E30.8 Other disorders of puberty
0.512 0.488 0.000
E30.1 Precocious puberty
0.512 0.488 0.000
E30.0 Delayed puberty
0.512 0.488 0.000
E32.9 Disease of thymus, unspecified
0.512 0.488 0.000
E32.8 Other diseases of thymus
0.512 0.488 0.000
E32.1 Abscess of thymus
0.512 0.488 0.000
E32.0 Persistent hyperplasia of thymus
0.512 0.488 0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.512 0.488 0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.512 0.488 0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.512 0.488 0.000
E27.9 Disorder of adrenal gland, unspecified
0.510 0.489 0.000
T45.0 Antiallergic and antiemetic drugs
0.000 0.490 0.510
E06 Thyroiditis
0.505 0.495 0.000
E34.5 Androgen resistance syndrome
0.505 0.495 0.000
E34.4 Constitutional tall stature
0.505 0.495 0.000
E34.3 Short stature, not elsewhere classified
0.505 0.495 0.000
E34.2 Ectopic hormone secretion, not elsewhere classified
0.505 0.495 0.000
E34.1 Other hypersecretion of intestinal hormones
0.505 0.495 0.000
E28 Ovarian dysfunction
0.502 0.497 0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified
0.000 0.500 0.500
T37.8 Other specified systemic anti-infectives and antiparasitics
0.000 0.500 0.500
T37.5 Antiviral drugs
0.000 0.500 0.500
T37.4 Anthelminthics
0.000 0.500 0.500
T37.3 Other antiprotozoal drugs
0.000 0.500 0.500
T37.2 Antimalarials and drugs acting on other blood protozoa
0.000 0.500 0.500
T37.1 Antimycobacterial drugs
0.000 0.500 0.500
T37.0 Sulphonamides
0.000 0.500 0.500
T41.5 Therapeutic gases
0.000 0.500 0.500
T41.4 Anaesthetic, unspecified
0.000 0.500 0.500
T41.3 Local anaesthetics
0.000 0.500 0.500
T41.2 Other and unspecified general anaesthetics
0.000 0.500 0.500
T41.1 Intravenous anaesthetics
0.000 0.500 0.500
T41.0 Inhaled anaesthetics
0.000 0.500 0.500
T48.7 Other and unspecified agents primarily acting on the respiratory system
0.000 0.500 0.500
T48.6 Antiasthmatics, not elsewhere classified
0.000 0.500 0.500
T48.5 Anti-common-cold drugs
0.000 0.500 0.500
T48.4 Expectorants
0.000 0.500 0.500
T48.3 Antitussives
0.000 0.500 0.500
T48.2 Other and unspecified agents primarily acting on muscles
0.000 0.500 0.500
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]
0.000 0.500 0.500
T48.0 Oxytocic drugs
0.000 0.500 0.500
T49.9 Topical agent, unspecified
0.000 0.500 0.500
T49.8 Other topical agents
0.000 0.500 0.500
T49.7 Dental drugs, topically applied
0.000 0.500 0.500
T49.6 Otorhinolaryngological drugs and preparations
0.000 0.500 0.500
T49.5 Ophthalmological drugs and preparations
0.000 0.500 0.500
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations
0.000 0.500 0.500
T49.3 Emollients, demulcents and protectants
0.000 0.500 0.500
T49.2 Local astringents and local detergents
0.000 0.500 0.500
T49.1 Antipruritics
0.000 0.500 0.500
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified
0.000 0.500 0.500
N40-N51 Diseases of male genital organs
0.000 0.503 0.497
T47.1 Other antacids and anti-gastric-secretion drugs
0.000 0.505 0.494
T45.2 Vitamins, not elsewhere classified
0.000 0.508 0.491
E14.4 With neurological complications
0.491 0.509 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.000 0.509 0.491
T45.8 Other primarily systemic and haematological agents
0.000 0.509 0.491
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.000 0.509 0.491
T45.6 Fibrinolysis-affecting drugs
0.000 0.509 0.491
T45.4 Iron and its compounds
0.000 0.509 0.491
T45.3 Enzymes, not elsewhere classified
0.000 0.509 0.491
E34.8 Other specified endocrine disorders
0.485 0.514 0.000
T45.5 Anticoagulants
0.000 0.517 0.483
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.483 0.517 0.000
N41 Inflammatory diseases of prostate
0.000 0.517 0.483
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.482 0.518 0.000
E23.1 Drug-induced hypopituitarism
0.482 0.518 0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.000 0.519 0.481
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.000 0.519 0.481
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.519 0.481
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.000 0.519 0.481
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.000 0.519 0.481
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.000 0.519 0.481
T44.1 Other parasympathomimetics [cholinergics]
0.000 0.519 0.481
T44.0 Anticholinesterase agents
0.000 0.519 0.481
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified
0.000 0.521 0.479
T47.8 Other agents primarily affecting the gastro-intestinal system
0.000 0.521 0.479
T47.7 Emetics
0.000 0.521 0.479
T47.6 Antidiarrhoeal drugs
0.000 0.521 0.479
T47.5 Digestants
0.000 0.521 0.479
T47.3 Saline and osmotic laxatives
0.000 0.521 0.479
T47.2 Stimulant laxatives
0.000 0.521 0.479
T47.0 Histamine H(2)-receptor antagonists
0.000 0.521 0.479
E23.2 Diabetes insipidus
0.479 0.521 0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.000 0.523 0.477
E23.6 Other disorders of pituitary gland
0.474 0.526 0.000
E53.9 Vitamin B deficiency, unspecified
0.473 0.527 0.000
F39 Unspecified mood [affective] disorder
0.000 0.528 0.472
N42 Other disorders of prostate
0.000 0.531 0.469
N41.1 Chronic prostatitis
0.000 0.531 0.469
E53.1 Pyridoxine deficiency
0.467 0.533 0.000
E53.0 Riboflavin deficiency
0.467 0.533 0.000
E29.9 Testicular dysfunction, unspecified
0.465 0.535 0.000
E29.8 Other testicular dysfunction
0.465 0.535 0.000
E29.0 Testicular hyperfunction
0.465 0.535 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.000 0.535 0.465
E22.0 Acromegaly and pituitary gigantism
0.461 0.539 0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.000 0.541 0.459
E26.9 Hyperaldosteronism, unspecified
0.458 0.541 0.000
E26.8 Other hyperaldosteronism
0.458 0.541 0.000
E26.1 Secondary hyperaldosteronism
0.458 0.541 0.000
E07.1 Dyshormogenetic goitre
0.458 0.542 0.000
E07.0 Hypersecretion of calcitonin
0.458 0.542 0.000
E56.1 Deficiency of vitamin K
0.456 0.543 0.000
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms
0.000 0.545 0.454
N41.0 Acute prostatitis
0.000 0.549 0.451
N42.8 Other specified disorders of prostate
0.000 0.554 0.446
E04 Other non-toxic goitre
0.444 0.555 0.001
F31 Bipolar affective disorder
0.000 0.556 0.444
T43.4 Butyrophenone and thioxanthene neuroleptics
0.000 0.558 0.441
F33.0 Recurrent depressive disorder, current episode mild
0.000 0.560 0.440
E34.0 Carcinoid syndrome
0.434 0.566 0.000
F30 Manic episode
0.000 0.568 0.432
T47.4 Other laxatives
0.000 0.569 0.431
E56.9 Vitamin deficiency, unspecified
0.429 0.571 0.000
E56.8 Deficiency of other vitamins
0.429 0.571 0.000
E56.0 Deficiency of vitamin E
0.429 0.571 0.000
F32.8 Other depressive episodes
0.000 0.573 0.427
E07.9 Disorder of thyroid, unspecified
0.426 0.573 0.000
E61.1 Iron deficiency
0.420 0.580 0.000
E07.8 Other specified disorders of thyroid
0.419 0.581 0.000
E61.2 Magnesium deficiency
0.415 0.585 0.000
E61.9 Deficiency of nutrient element, unspecified
0.414 0.586 0.000
E61.8 Deficiency of other specified nutrient elements
0.414 0.586 0.000
E61.7 Deficiency of multiple nutrient elements
0.414 0.586 0.000
E61.6 Vanadium deficiency
0.414 0.586 0.000
E61.5 Molybdenum deficiency
0.414 0.586 0.000
E61.4 Chromium deficiency
0.414 0.586 0.000
E61.3 Manganese deficiency
0.414 0.586 0.000
E61.0 Copper deficiency
0.414 0.586 0.000
T38.9 Other and unspecified hormone antagonists
0.000 0.586 0.414
T38.8 Other and unspecified hormones and their synthetic substitutes
0.000 0.586 0.414
T38.7 Androgens and anabolic congeners
0.000 0.586 0.414
T38.6 Antigonadotrophins. antioestrogens, antiandrogens, not elsewhere classified
0.000 0.586 0.414
T38.5 Other oestrogens and progestogens
0.000 0.586 0.414
T38.4 Oral contraceptives
0.000 0.586 0.414
T38.2 Antithyroid drugs
0.000 0.586 0.414
T38.0 Glucocorticoids and synthetic analogues
0.000 0.586 0.414
E04.9 Non-toxic goitre, unspecified
0.410 0.590 0.000
E50.9 Vitamin A deficiency, unspecified
0.409 0.590 0.000
E50.8 Other manifestations of vitamin A deficiency
0.409 0.590 0.000
E50.7 Other ocular manifestations of vitamin A deficiency
0.409 0.590 0.000
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.409 0.590 0.000
E50.5 Vitamin A deficiency with night blindness
0.409 0.590 0.000
E50.4 Vitamin A deficiency with keratomalacia
0.409 0.590 0.000
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.409 0.590 0.000
E50.2 Vitamin A deficiency with corneal xerosis
0.409 0.590 0.000
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.409 0.590 0.000
E50.0 Vitamin A deficiency with conjunctival xerosis
0.409 0.590 0.000
E63.9 Nutritional deficiency, unspecified
0.409 0.590 0.000
E63.8 Other specified nutritional deficiencies
0.409 0.590 0.000
E63.1 Imbalance of constituents of food intake
0.409 0.590 0.000
E63.0 Essential fatty acid [EFA] deficiency
0.409 0.590 0.000
E64.9 Sequelae of unspecified nutritional deficiency
0.409 0.590 0.000
E64.8 Sequelae of other nutritional deficiencies
0.409 0.590 0.000
E64.3 Sequelae of rickets
0.409 0.590 0.000
E64.2 Sequelae of vitamin C deficiency
0.409 0.590 0.000
E64.1 Sequelae of vitamin A deficiency
0.409 0.590 0.000
E64.0 Sequelae of protein-energy malnutrition
0.409 0.590 0.000
E27.8 Other specified disorders of adrenal gland
0.408 0.591 0.001
F34 Persistent mood [affective] disorders
0.000 0.594 0.406
E51.9 Thiamine deficiency, unspecified
0.402 0.597 0.000
E51.8 Other manifestations of thiamine deficiency
0.402 0.597 0.000
E51.1 Beriberi
0.402 0.597 0.000
E44.1 Mild protein-energy malnutrition
0.399 0.601 0.000
E44.0 Moderate protein-energy malnutrition
0.399 0.601 0.000
E29.1 Testicular hypofunction
0.399 0.601 0.000
F38 Other mood [affective] disorders
0.000 0.603 0.397
T38.1 Thyroid hormones and substitutes
0.000 0.605 0.395
E51.2 Wernicke's encephalopathy
0.393 0.607 0.000
F33.8 Other recurrent depressive disorders
0.000 0.609 0.391
F33.4 Recurrent depressive disorder, currently in remission
0.000 0.609 0.391
N49 Inflammatory disorders of male genital organs, not elsewhere classified
0.000 0.609 0.391
E23.0 Hypopituitarism
0.389 0.611 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.000 0.611 0.389
T46.8 Antivaricose drugs, including sclerosing agents
0.000 0.611 0.389
T46.7 Peripheral vasodilators
0.000 0.611 0.389
T46.3 Coronary vasodilators, not elsewhere classified
0.000 0.611 0.389
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.000 0.611 0.389
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.000 0.611 0.389
F33.1 Recurrent depressive disorder, current episode moderate
0.000 0.611 0.389
E55.0 Rickets, active
0.388 0.611 0.000
T46.1 Calcium-channel blockers
0.000 0.613 0.387
F31.0 Bipolar affective disorder, current episode hypomanic
0.000 0.614 0.386
E26.0 Primary hyperaldosteronism
0.383 0.617 0.000
N42.0 Calculus of prostate
0.000 0.617 0.383
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.000 0.622 0.378
N46 Male infertility
0.000 0.631 0.369
T46.5 Other antihypertensive drugs, not elsewhere classified
0.000 0.634 0.365
N42.1 Congestion and haemorrhage of prostate
0.000 0.635 0.365
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.000 0.636 0.364
T46.4 Angiotensin-converting-enzyme inhibitors
0.000 0.637 0.363
N42.2 Atrophy of prostate
0.000 0.637 0.363
E06.5 Other chronic thyroiditis
0.362 0.638 0.000
E06.4 Drug-induced thyroiditis
0.362 0.638 0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.362 0.638 0.000
E06.1 Subacute thyroiditis
0.362 0.638 0.000
E06.0 Acute thyroiditis
0.362 0.638 0.000
F30.0 Hypomania
0.000 0.639 0.361
E28.9 Ovarian dysfunction, unspecified
0.360 0.639 0.000
E28.8 Other ovarian dysfunction
0.360 0.639 0.000
E28.1 Androgen excess
0.360 0.639 0.000
E28.0 Oestrogen excess
0.360 0.639 0.000
E55.9 Vitamin D deficiency, unspecified
0.359 0.641 0.000
E24.9 Cushing's syndrome, unspecified
0.357 0.642 0.001
N51 Disorders of male genital organs in diseases classified elsewhere
0.000 0.644 0.356
E11 Non-insulin-dependent diabetes mellitus
0.356 0.644 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.000 0.651 0.349
N41.3 Prostatocystitis
0.000 0.654 0.346
N41.2 Abscess of prostate
0.000 0.654 0.346
N49.2 Inflammatory disorders of scrotum
0.000 0.659 0.341
N42.3 Dysplasia of prostate
0.000 0.663 0.336
F32.1 Moderate depressive episode
0.000 0.665 0.335
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs
0.000 0.676 0.324
N44 Torsion of testis
0.000 0.677 0.322
N48 Other disorders of penis
0.000 0.678 0.322
E04.8 Other specified non-toxic goitre
0.318 0.681 0.001
F31.7 Bipolar affective disorder, currently in remission
0.000 0.681 0.319
E06.9 Thyroiditis, unspecified
0.317 0.682 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.000 0.685 0.315
F30.8 Other manic episodes
0.000 0.690 0.310
F30.1 Mania without psychotic symptoms
0.000 0.690 0.310
E65-E68 Obesity and other hyperalimentation
0.309 0.691 0.000
F30.9 Manic episode, unspecified
0.000 0.693 0.307
F33.3 Recurrent depressive disorder, current episode severe with psychotic symptoms
0.000 0.698 0.302
D12.8 Rectum
0.000 0.699 0.301
F34.1 Dysthymia
0.000 0.700 0.300
E11.5 With peripheral circulatory complications
0.298 0.702 0.000
E04.0 Non-toxic diffuse goitre
0.295 0.704 0.001
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.000 0.705 0.295
E28.3 Primary ovarian failure
0.293 0.707 0.000
N41.8 Other inflammatory diseases of prostate
0.000 0.707 0.293
N48.1 Balanoposthitis
0.000 0.708 0.292
F34.9 Persistent mood [affective] disorder, unspecified
0.000 0.709 0.291
F34.8 Other persistent mood [affective] disorders
0.000 0.709 0.291
F34.0 Cyclothymia
0.000 0.709 0.291
F30.2 Mania with psychotic symptoms
0.000 0.713 0.287
F31.8 Other bipolar affective disorders
0.000 0.713 0.287
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.000 0.714 0.285
F38.8 Other specified mood [affective] disorders
0.000 0.715 0.285
F38.1 Other recurrent mood [affective] disorders
0.000 0.715 0.285
F38.0 Other single mood [affective] disorders
0.000 0.715 0.285
N48.2 Other inflammatory disorders of penis
0.000 0.718 0.282
N49.9 Inflammatory disorder of unspecified male genital organ
0.000 0.720 0.280
N49.1 Inflammatory disorders of spermatic cord, tunica vaginalis and vas deferens
0.000 0.720 0.280
N49.0 Inflammatory disorders of seminal vesicle
0.000 0.720 0.280
F32.3 Severe depressive episode with psychotic symptoms
0.000 0.726 0.274
F32.0 Mild depressive episode
0.000 0.727 0.272
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.000 0.729 0.271
E11.1 With ketoacidosis
0.264 0.736 0.000
E11.0 With coma
0.264 0.736 0.000
E28.2 Polycystic ovarian syndrome
0.262 0.737 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.000 0.738 0.262

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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