TreeWAS – Variant ID: rs173896

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
H66.3 Other chronic suppurative otitis media	0.018	0.982	0.000
H66 Suppurative and unspecified otitis media	0.018	0.982	0.000
H71 Cholesteatoma of middle ear	0.017	0.983	0.000
H65-H75 Diseases of middle ear and mastoid	0.016	0.984	0.000
H66.0 Acute suppurative otitis media	0.016	0.984	0.000
H66.1 Chronic tubotympanic suppurative otitis media	0.014	0.985	0.000
Chapter VIII Diseases of the ear and mastoid process	0.013	0.987	0.000
H72 Perforation of tympanic membrane	0.013	0.987	0.000
H69 Other disorders of Eustachian tube	0.013	0.987	0.000
H66.4 Suppurative otitis media, unspecified	0.013	0.987	0.000
H66.2 Chronic atticoantral suppurative otitis media	0.013	0.987	0.000
H90-H95 Other disorders of ear	0.013	0.987	0.000
H70 Mastoiditis and related conditions	0.012	0.988	0.000
H90 Conductive and sensorineural hearing loss	0.012	0.988	0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.012	0.988	0.000
H68 Eustachian salpingitis and obstruction	0.012	0.988	0.000
H67 Otitis media in diseases classified elsewhere	0.012	0.988	0.000
H80-H83 Diseases of inner ear	0.012	0.988	0.000
H72.1 Attic perforation of tympanic membrane	0.012	0.988	0.000
H83.0 Labyrinthitis	0.011	0.989	0.000
H83 Other diseases of inner ear	0.011	0.989	0.000
H90.2 Conductive hearing loss, unspecified	0.011	0.989	0.000
H69.9 Eustachian tube disorder, unspecified	0.011	0.989	0.000
H73 Other disorders of tympanic membrane	0.011	0.989	0.000
H72.2 Other marginal perforations of tympanic membrane	0.011	0.989	0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.011	0.989	0.000
H72.8 Other perforations of tympanic membrane	0.010	0.989	0.000
H90.5 Sensorineural hearing loss, unspecified	0.010	0.990	0.000
H90.3 Sensorineural hearing loss, bilateral	0.010	0.990	0.000
H92 Otalgia and effusion of ear	0.010	0.990	0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.010	0.990	0.000
H93 Other disorders of ear, not elsewhere classified	0.010	0.990	0.000
H69.0 Patulous Eustachian tube	0.009	0.990	0.000
N31.8 Other neuromuscular dysfunction of bladder	0.010	0.990	0.000
H60-H62 Diseases of external ear	0.009	0.991	0.000
Y44.2 Anticoagulants	0.009	0.991	0.000
H94 Other disorders of ear in diseases classified elsewhere	0.009	0.991	0.000
S82.80 Fractures of other parts of lower leg (closed)	0.000	0.991	0.009
H70.9 Mastoiditis, unspecified	0.009	0.991	0.000
H90.0 Conductive hearing loss, bilateral	0.009	0.991	0.000
H70.8 Other mastoiditis and related conditions	0.009	0.991	0.000
H70.2 Petrositis	0.009	0.991	0.000
H70.1 Chronic mastoiditis	0.009	0.991	0.000
H70.0 Acute mastoiditis	0.009	0.991	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.009	0.991	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.009	0.991	0.000
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity	0.009	0.991	0.000
H67.8 Otitis media in other diseases classified elsewhere	0.009	0.991	0.000
H67.1 Otitis media in viral diseases classified elsewhere	0.009	0.991	0.000
H67.0 Otitis media in bacterial diseases classified elsewhere	0.009	0.991	0.000
H68.1 Obstruction of Eustachian tube	0.009	0.991	0.000
H68.0 Eustachian salpingitis	0.009	0.991	0.000
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere	0.009	0.991	0.000
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere	0.009	0.991	0.000
H69.8 Other specified disorders of Eustachian tube	0.009	0.991	0.000
Y44 Agents primarily affecting blood constituents	0.009	0.991	0.000
H66.9 Otitis media, unspecified	0.009	0.991	0.000
H82 Vertiginous syndromes in diseases classified elsewhere	0.009	0.991	0.000
H83.9 Disease of inner ear, unspecified	0.008	0.992	0.000
H83.8 Other specified diseases of inner ear	0.008	0.992	0.000
H83.3 Noise effects on inner ear	0.008	0.992	0.000
H83.2 Labyrinthine dysfunction	0.008	0.992	0.000
H83.1 Labyrinthine fistula	0.008	0.992	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.008	0.992	0.000
H95.1 Other disorders following mastoidectomy	0.008	0.992	0.000
H18.4 Corneal degeneration	0.008	0.992	0.000
H81 Disorders of vestibular function	0.008	0.992	0.000
H92.0 Otalgia	0.008	0.992	0.000
H73.9 Disorder of tympanic membrane, unspecified	0.008	0.992	0.000
H73.1 Chronic myringitis	0.008	0.992	0.000
H73.0 Acute myringitis	0.008	0.992	0.000
Y40 Systemic antibiotics	0.008	0.992	0.000
H72.9 Perforation of tympanic membrane, unspecified	0.008	0.992	0.000
H65 Nonsuppurative otitis media	0.008	0.992	0.000
H95.9 Postprocedural disorder of ear and mastoid process, unspecified	0.008	0.992	0.000
H95.8 Other postprocedural disorders of ear and mastoid process	0.008	0.992	0.000
H61.0 Perichondritis of external ear	0.008	0.992	0.000
E04.1 Non-toxic single thyroid nodule	0.008	0.992	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.008	0.992	0.000
Y52 Agents primarily affecting the cardiovascular system	0.008	0.992	0.000
Y40.0 Penicillins	0.008	0.992	0.000
H92.1 Otorrhoea	0.008	0.992	0.000
H18 Other disorders of cornea	0.008	0.992	0.000
H61 Other disorders of external ear	0.008	0.992	0.000
H80 Otosclerosis	0.007	0.992	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.007	0.992	0.000
H92.2 Otorrhagia	0.007	0.992	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.007	0.992	0.000
H81.0 Meniere's disease	0.007	0.993	0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.007	0.993	0.000
H93.1 Tinnitus	0.007	0.993	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.007	0.993	0.000
Y42.5 Other oestrogens and progestogens	0.007	0.993	0.000
H74 Other disorders of middle ear and mastoid	0.007	0.993	0.000
Y48 Anaesthetics and therapeutic gases	0.007	0.993	0.000
H72.0 Central perforation of tympanic membrane	0.007	0.993	0.000
H93.9 Disorder of ear, unspecified	0.007	0.993	0.000
H93.8 Other specified disorders of ear	0.007	0.993	0.000
H93.3 Disorders of acoustic nerve	0.007	0.993	0.000
H93.2 Other abnormal auditory perceptions	0.007	0.993	0.000
H93.0 Degenerative and vascular disorders of ear	0.007	0.993	0.000
L90.5 Scar conditions and fibrosis of skin	0.007	0.993	0.000
Y40.8 Other systemic antibiotics	0.007	0.993	0.000
H62 Disorders of external ear in diseases classified elsewhere	0.007	0.993	0.000
H94.8 Other specified disorders of ear in diseases classified elsewhere	0.007	0.993	0.000
H94.0 Acoustic neuritis in infectious and parasitic diseases classified elsewhere	0.007	0.993	0.000
H73.8 Other specified disorders of tympanic membrane	0.007	0.993	0.000
Y46.4 Iminostilbenes	0.007	0.993	0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.006	0.993	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.007	0.993	0.000
Y44.9 Other and unspecified agents affecting blood constituents	0.006	0.993	0.000
Y44.7 Plasma substitutes	0.006	0.993	0.000
Y44.6 Natural blood and blood products	0.006	0.993	0.000
Y44.5 Thrombolytic drugs	0.006	0.993	0.000
Y44.4 Antithrombotic drugs [platelet-aggregation inhibitors]	0.006	0.993	0.000
Y44.3 Anticoagulant antagonists, vitamin K and other coagulants	0.006	0.993	0.000
Y44.1 Vitamin B12, folic acid and other anti-megaloblastic-anaemia preparations	0.006	0.993	0.000
Y44.0 Iron preparations and other anti-hypochromic-anaemia preparations	0.006	0.993	0.000
J35.1 Hypertrophy of tonsils	0.000	0.993	0.007
H91 Other hearing loss	0.006	0.993	0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.007	0.993	0.000
H18.8 Other specified disorders of cornea	0.006	0.994	0.000
Y42.6 Antigonadotrophins, antioestrogens, antiandrogens, not elsewhere classified	0.006	0.994	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.006	0.994	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.006	0.994	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.006	0.994	0.000
H18.6 Keratoconus	0.006	0.994	0.000
Y59 Other and unspecified vaccines and biological substances	0.006	0.994	0.000
Y58 Bacterial vaccines	0.006	0.994	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.006	0.994	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.006	0.994	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.006	0.994	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.006	0.994	0.000
J35.0 Chronic tonsillitis	0.000	0.994	0.006
Y54.4 Loop [high-ceiling] diuretics	0.006	0.994	0.000
Y54.3 Benzothiadiazine derivatives	0.006	0.994	0.000
H65.9 Nonsuppurative otitis media, unspecified	0.006	0.994	0.000
H81.8 Other disorders of vestibular function	0.006	0.994	0.000
H81.4 Vertigo of central origin	0.006	0.994	0.000
H81.3 Other peripheral vertigo	0.006	0.994	0.000
H81.9 Disorder of vestibular function, unspecified	0.006	0.994	0.000
Y48.3 Local anaesthetics	0.006	0.994	0.000
Y40.7 Antifungal antibiotics, systemically used	0.006	0.994	0.000
Y40.6 Rifamycins	0.006	0.994	0.000
Y40.5 Aminoglycosides	0.006	0.994	0.000
Y40.4 Tetracyclines	0.006	0.994	0.000
Y40.2 Chloramphenicol group	0.006	0.994	0.000
H65.1 Other acute nonsuppurative otitis media	0.006	0.994	0.000
H65.0 Acute serous otitis media	0.006	0.994	0.000
Y54.8 Agents affecting uric acid metabolism	0.006	0.994	0.000
H60 Otitis externa	0.006	0.994	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.006	0.994	0.000
H61.3 Acquired stenosis of external ear canal	0.006	0.994	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.006	0.994	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.006	0.994	0.000
Y52.7 Peripheral vasodilators	0.006	0.994	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.006	0.994	0.000
J35 Chronic diseases of tonsils and adenoids	0.000	0.994	0.006
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.006	0.994	0.000
Y40.9 Systemic antibiotic, unspecified	0.006	0.994	0.000
Y48.4 Anaesthetic, unspecified	0.006	0.994	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.006	0.994	0.000
H18.7 Other corneal deformities	0.006	0.994	0.000
H18.3 Changes in corneal membranes	0.006	0.994	0.000
H18.1 Bullous keratopathy	0.006	0.994	0.000
H18.0 Corneal pigmentations and deposits	0.006	0.994	0.000
H74.2 Discontinuity and dislocation of ear ossicles	0.005	0.994	0.000
H18.5 Hereditary corneal dystrophies	0.006	0.994	0.000
H61.9 Disorder of external ear, unspecified	0.006	0.994	0.000
Y46.2 Hydantoin derivatives	0.006	0.994	0.000
H80.8 Other otosclerosis	0.005	0.994	0.000
H80.2 Cochlear otosclerosis	0.005	0.994	0.000
H80.1 Otosclerosis involving oval window, obliterative	0.005	0.994	0.000
H80.0 Otosclerosis involving oval window, nonobliterative	0.005	0.994	0.000
H21 Other disorders of iris and ciliary body	0.006	0.994	0.000
H18.9 Disorder of cornea, unspecified	0.006	0.994	0.000
Y46.8 Antispasticity drugs	0.005	0.994	0.000
Y46.7 Anti-Parkinsonism drugs	0.005	0.994	0.000
Y46.6 Other and unspecified antiepileptics	0.005	0.994	0.000
Y46.5 Valproic acid	0.005	0.994	0.000
Y46.3 Deoxybarbiturates	0.005	0.994	0.000
Y46.1 Oxazolidinediones	0.005	0.994	0.000
Y46.0 Succinimides	0.005	0.994	0.000
H65.2 Chronic serous otitis media	0.005	0.994	0.000
Y54.9 Mineral salts, not elsewhere classified	0.005	0.994	0.000
Y54.7 Agents affecting calcification	0.005	0.994	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.005	0.994	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.005	0.994	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.005	0.994	0.000
Y54.0 Mineralocorticoids	0.005	0.994	0.000
H20 Iridocyclitis	0.006	0.994	0.000
Y52.1 Calcium-channel blockers	0.005	0.994	0.000
Y54.5 Other diuretics	0.005	0.994	0.000
H61.1 Non-infective disorders of pinna	0.005	0.994	0.000
S82.8 Fractures of other parts of lower leg	0.000	0.994	0.005
Y42.9 Other and unspecified hormone antagonists	0.005	0.994	0.000
Y42.4 Oral contraceptives	0.005	0.994	0.000
Y42.2 Antithyroid drugs	0.005	0.994	0.000
Y42.1 Thyroid hormones and substitutes	0.005	0.994	0.000
Y42.0 Glucocorticoids and synthetic analogs	0.005	0.994	0.000
Y40.1 Cefalosporins and other -lactam antibiotics	0.005	0.994	0.000
Y42.8 Other and unspecified hormones and their synthetic substitutes	0.005	0.994	0.000
H74.9 Disorder of middle ear and mastoid, unspecified	0.005	0.995	0.000
H74.1 Adhesive middle ear disease	0.005	0.995	0.000
H19 Disorders of sclera and cornea in diseases classified elsewhere	0.005	0.995	0.000
Y48.5 Therapeutic gases	0.005	0.995	0.000
Y48.2 Other and unspecified general anaesthetics	0.005	0.995	0.000
Y48.1 Parenteral anaesthetics	0.005	0.995	0.000
Y48.0 Inhaled anaesthetics	0.005	0.995	0.000
Y40.3 Macrolides	0.005	0.995	0.000
H16 Keratitis	0.005	0.995	0.000
M72.04 Palmar fascial fibromatosis [Dupuytren]-Hand	0.005	0.995	0.000
H18.2 Other corneal oedema	0.005	0.995	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.005	0.995	0.000
H62.8 Other disorders of external ear in diseases classified elsewhere	0.005	0.995	0.000
H62.4 Otitis externa in other diseases classified elsewhere	0.005	0.995	0.000
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere	0.005	0.995	0.000
H62.2 Otitis externa in mycoses	0.005	0.995	0.000
H62.1 Otitis externa in viral diseases classified elsewhere	0.005	0.995	0.000
H62.0 Otitis externa in bacterial diseases classified elsewhere	0.005	0.995	0.000
H91.3 Deaf mutism, not elsewhere classified	0.005	0.995	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.005	0.995	0.000
H17 Corneal scars and opacities	0.005	0.995	0.000
H74.3 Other acquired abnormalities of ear ossicles	0.005	0.995	0.000
H65.4 Other chronic nonsuppurative otitis media	0.005	0.995	0.000
H21.8 Other specified disorders of iris and ciliary body	0.005	0.995	0.000
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.005	0.995	0.000
H91.1 Presbycusis	0.005	0.995	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.005	0.995	0.000
Y41.5 Antiviral drugs	0.005	0.995	0.000
Y41.4 Anthelminthics	0.005	0.995	0.000
Y41.3 Other antiprotozoal drugs	0.005	0.995	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.005	0.995	0.000
Y41.1 Antimycobacterial drugs	0.005	0.995	0.000
Y41.0 Sulphonamides	0.005	0.995	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.005	0.995	0.000
H74.0 Tympanosclerosis	0.005	0.995	0.000
H91.2 Sudden idiopathic hearing loss	0.005	0.995	0.000
H91.0 Ototoxic hearing loss	0.005	0.995	0.000
J35.9 Chronic disease of tonsils and adenoids, unspecified	0.000	0.995	0.005
Y47.1 Benzodiazepines	0.005	0.995	0.000
H22 Disorders of iris and ciliary body in diseases classified elsewhere	0.005	0.995	0.000
H15 Disorders of sclera	0.005	0.995	0.000
Y56.9 Topical agent, unspecified	0.005	0.995	0.000
Y56.8 Other topical agents	0.005	0.995	0.000
Y56.7 Dental drugs, topically applied	0.005	0.995	0.000
Y56.6 Otorhinolaryngological drugs and preparations	0.005	0.995	0.000
Y56.5 Ophthalmological drugs and preparations	0.005	0.995	0.000
Y56.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.005	0.995	0.000
Y56.3 Emollients, demulcents and protectants	0.005	0.995	0.000
Y56.2 Local astringents and local detergents	0.005	0.995	0.000
Y56.1 Antipruritics	0.005	0.995	0.000
E04 Other non-toxic goitre	0.005	0.995	0.000
H60.1 Cellulitis of external ear	0.005	0.995	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.005	0.995	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.005	0.995	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.005	0.995	0.000
Y47.4 Bromine compounds	0.005	0.995	0.000
Y47.3 Paraldehyde	0.005	0.995	0.000
Y47.2 Chloral derivatives	0.005	0.995	0.000
Y47.0 Barbiturates, not elsewhere classified	0.005	0.995	0.000
Y50.9 Central nervous system stimulant, unspecified	0.005	0.995	0.000
Y50.8 Other central nervous system stimulants	0.005	0.995	0.000
Y50.2 Methylxanthines, not elsewhere classified	0.005	0.995	0.000
Y50.1 Opioid receptor antagonists	0.005	0.995	0.000
Y50.0 Analeptics	0.005	0.995	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.005	0.995	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.005	0.995	0.000
Y55.5 Anticommon cold drugs	0.005	0.995	0.000
Y55.4 Expectorants	0.005	0.995	0.000
Y55.3 Antitussives	0.005	0.995	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.005	0.995	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.005	0.995	0.000
Y55.0 Oxytocic drugs	0.005	0.995	0.000
Y58.9 Other and unspecified bacterial vaccines	0.005	0.995	0.000
Y58.8 Mixed bacterial vaccines, except combinations with a pertussis component	0.005	0.995	0.000
Y58.6 Pertussis vaccine, including combinations with a pertussis component	0.005	0.995	0.000
Y58.5 Diphtheria vaccine	0.005	0.995	0.000
Y58.4 Tetanus vaccine	0.005	0.995	0.000
Y58.3 Plague vaccine	0.005	0.995	0.000
Y58.2 Cholera vaccine	0.005	0.995	0.000
Y58.1 Typhoid and paratyphoid vaccine	0.005	0.995	0.000
Y58.0 BCG vaccine	0.005	0.995	0.000
Y59.9 Vaccine or biological substance, unspecified	0.005	0.995	0.000
Y59.8 Other specified vaccines and biological substances	0.005	0.995	0.000
Y59.3 Immunoglobulin	0.005	0.995	0.000
Y59.2 Protozoal vaccines	0.005	0.995	0.000
Y59.1 Rickettsial vaccines	0.005	0.995	0.000
Y59.0 Viral vaccines	0.005	0.995	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.005	0.995	0.000
H20.9 Iridocyclitis, unspecified	0.005	0.995	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.005	0.995	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.005	0.995	0.000
Y53.7 Emetics	0.005	0.995	0.000
Y53.6 Antidiarrhoeal drugs	0.005	0.995	0.000
Y53.5 Digestants	0.005	0.995	0.000
Y53.4 Other laxatives	0.005	0.995	0.000
Y53.3 Saline and osmotic laxatives	0.005	0.995	0.000
Y53.2 Stimulant laxatives	0.005	0.995	0.000
Y53.0 Histamine H2-receptor antagonists	0.005	0.995	0.000
H19.1 Herpesviral keratitis and keratoconjunctivitis	0.005	0.995	0.000
H20.8 Other iridocyclitis	0.005	0.995	0.000
J35.8 Other chronic diseases of tonsils and adenoids	0.000	0.995	0.005
H20.1 Chronic iridocyclitis	0.005	0.995	0.000
H81.2 Vestibular neuronitis	0.004	0.995	0.000
H81.1 Benign paroxysmal vertigo	0.005	0.995	0.000
Y53.1 Other antacids and anti-gastric-secretion drugs	0.005	0.995	0.000
Y42.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.004	0.995	0.000
I50.0 Congestive heart failure	0.000	0.995	0.005
H60.5 Acute otitis externa, non-infective	0.004	0.995	0.000
E04.9 Non-toxic goitre, unspecified	0.005	0.995	0.000
H80.9 Otosclerosis, unspecified	0.004	0.995	0.000
H60.4 Cholesteatoma of external ear	0.004	0.995	0.000
H60.2 Malignant otitis externa	0.004	0.995	0.000
H60.0 Abscess of external ear	0.004	0.995	0.000
H91.8 Other specified hearing loss	0.004	0.995	0.000
S82.81 Fractures of other parts of lower leg (open)	0.000	0.995	0.004
H21.1 Other vascular disorders of iris and ciliary body	0.004	0.995	0.000
H60.3 Other infective otitis externa	0.004	0.995	0.000
Y49.9 Psychotropic drug, unspecified	0.004	0.995	0.000
Y49.8 Other psychotropic drugs, not elsewhere classified	0.004	0.995	0.000
Y49.7 Psychostimulants with abuse potential	0.004	0.995	0.000
Y49.6 Psychodysleptics [hallucinogens]	0.004	0.995	0.000
Y49.4 Butyrophenone and thioxanthene neuroleptics	0.004	0.995	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.004	0.995	0.000
Y49.2 Other and unspecified antidepressants	0.004	0.995	0.000
Y49.1 Monoamine-oxidase-inhibitor antidepressants	0.004	0.995	0.000
Y49.0 Tricyclic and tetracyclic antidepressants	0.004	0.995	0.000
Y52.4 Angiotensin-converting-enzyme inhibitors	0.004	0.995	0.000
H16.0 Corneal ulcer	0.004	0.995	0.000
N84.1 Polyp of cervix uteri	0.000	0.995	0.005
Y45.1 Salicylates	0.004	0.996	0.000
H60.8 Other otitis externa	0.004	0.996	0.000
J35.3 Hypertrophy of tonsils with hypertrophy of adenoids	0.000	0.996	0.004
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.004	0.996	0.000
Y45.8 Other analgesics and antipyretics	0.004	0.996	0.000
Y45.5 4-Aminophenol derivatives	0.004	0.996	0.000
Y45.4 Antirheumatics	0.004	0.996	0.000
Y51.9 Other and unspecified drugs primarily affecting the autonomic nervous system	0.004	0.996	0.000
Y51.8 Centrally acting and adrenergic-neuron-blocking agents, not elsewhere classified	0.004	0.996	0.000
Y51.6 @-Adrenoreceptor antagonists, not elsewhere classified	0.004	0.996	0.000
Y51.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.004	0.996	0.000
Y51.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.004	0.996	0.000
Y51.3 Other parasympatholytics [anticholinergics and antimuscarinics] and spasmolytics, not elsewhere classified	0.004	0.996	0.000
Y51.2 Ganglionic blocking drugs, not elsewhere classified	0.004	0.996	0.000
Y51.1 Other parasympathomimetics [cholinergics]	0.004	0.996	0.000
Y51.0 Anticholinesterase agents	0.004	0.996	0.000
Y57 Other and unspecified drugs and medicaments	0.004	0.996	0.000
H21.9 Disorder of iris and ciliary body, unspecified	0.004	0.996	0.000
H21.4 Pupillary membranes	0.004	0.996	0.000
H21.3 Cyst of iris, ciliary body and anterior chamber	0.004	0.996	0.000
H21.2 Degeneration of iris and ciliary body	0.004	0.996	0.000
H21.0 Hyphaema	0.004	0.996	0.000
H16.9 Keratitis, unspecified	0.004	0.996	0.000
H20.2 Lens-induced iridocyclitis	0.004	0.996	0.000
H17.9 Corneal scar and opacity, unspecified	0.004	0.996	0.000
H21.5 Other adhesions and disruptions of iris and ciliary body	0.004	0.996	0.000
J35.2 Hypertrophy of adenoids	0.000	0.996	0.004
H61.8 Other specified disorders of external ear	0.004	0.996	0.000
S82.86 Maisonneuve's fracture	0.000	0.996	0.004
H19.8 Other disorders of sclera and cornea in diseases classified elsewhere	0.004	0.996	0.000
H19.3 Keratitis and keratoconjunctivitis in other diseases classified elsewhere	0.004	0.996	0.000
H19.2 Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere	0.004	0.996	0.000
H19.0 Scleritis and episcleritis in diseases classified elsewhere	0.004	0.996	0.000
R26.8 Other and unspecified abnormalities of gait and mobility	0.000	0.996	0.004
H16.8 Other keratitis	0.004	0.996	0.000
H16.4 Corneal neovascularisation	0.004	0.996	0.000
H16.3 Interstitial and deep keratitis	0.004	0.996	0.000
H16.2 Keratoconjunctivitis	0.004	0.996	0.000
H16.1 Other superficial keratitis without conjunctivitis	0.004	0.996	0.000
H74.8 Other specified disorders of middle ear and mastoid	0.004	0.996	0.001
Y49.5 Other antipsychotics and neuroleptics	0.004	0.996	0.000
Y45.0 Opioids and related analgesics	0.004	0.996	0.000
H74.4 Polyp of middle ear	0.004	0.996	0.001
H17.8 Other corneal scars and opacities	0.004	0.996	0.000
H17.1 Other central corneal opacity	0.004	0.996	0.000
H17.0 Adherent leukoma	0.004	0.996	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.004	0.996	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.004	0.996	0.000
R29.8 Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems	0.000	0.996	0.004
T39.1 4-Aminophenol derivatives	0.004	0.996	0.000
Y51.7 Beta-Adrenoreceptor antagonists, not elsewhere classified	0.004	0.996	0.000
L90 Atrophic disorders of skin	0.004	0.996	0.000
H15.9 Disorder of sclera, unspecified	0.004	0.996	0.000
H15.8 Other disorders of sclera	0.004	0.996	0.000
H15.1 Episcleritis	0.004	0.996	0.000
H15.0 Scleritis	0.004	0.996	0.000
H22.8 Other disorders of iris and ciliary body in diseases classified elsewhere	0.004	0.996	0.000
H22.1 Iridocyclitis in other diseases classified elsewhere	0.004	0.996	0.000
H22.0 Iridocyclitis in infectious and parasitic diseases classified elsewhere	0.004	0.996	0.000
E04.8 Other specified non-toxic goitre	0.004	0.996	0.000
H61.2 Impacted cerumen	0.004	0.996	0.000
H20.0 Acute and subacute iridocyclitis	0.004	0.996	0.000
E04.2 Non-toxic multinodular goitre	0.004	0.996	0.000
Z87.2 Personal history of diseases of the skin and subcutaneous tissue	0.004	0.996	0.000
Y45.2 Propionic acid derivatives	0.003	0.996	0.000
R29 Other symptoms and signs involving the nervous and musculoskeletal systems	0.000	0.996	0.004
C25.9 Pancreas, unspecified	0.000	0.996	0.004
E04.0 Non-toxic diffuse goitre	0.003	0.996	0.000
H65.3 Chronic mucoid otitis media	0.003	0.996	0.000
R26 Abnormalities of gait and mobility	0.000	0.996	0.004
Z87.0 Personal history of diseases of the respiratory system	0.004	0.996	0.000
Y57.8 Other drugs and medicaments	0.003	0.996	0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified	0.003	0.997	0.000
I50.9 Heart failure, unspecified	0.000	0.997	0.003
Y57.7 Vitamins, not elsewhere classified	0.003	0.997	0.000
Y57.6 Other diagnostic agents	0.003	0.997	0.000
Y57.4 Pharmaceutical excipients	0.003	0.997	0.000
Y57.3 Alcohol deterrents	0.003	0.997	0.000
Y57.2 Antidotes and chelating agents, not elsewhere classified	0.003	0.997	0.000
Y57.1 Lipotropic drugs	0.003	0.997	0.000
Y57.0 Appetite depressants [anorectics]	0.003	0.997	0.000
L90.0 Lichen sclerosus et atrophicus	0.003	0.997	0.000
R29.6 Tendency to fall, not elsewhere classified	0.000	0.997	0.003
M72.0 Palmar fascial fibromatosis [Dupuytren]	0.003	0.997	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.003	0.997	0.000
M77.12 Lateral epicondylitis (Upper arm)	0.003	0.997	0.000
Y42.7 Androgens and anabolic congeners	0.003	0.997	0.000
H44.2 Degenerative myopia	0.000	0.997	0.003
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.003	0.997	0.000
T39.4 Antirheumatics, not elsewhere classified	0.003	0.997	0.000
T39.2 Pyrazolone derivatives	0.003	0.997	0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.000	0.997	0.003
R26.2 Difficulty in walking, not elsewhere classified	0.000	0.997	0.003
T39.0 Salicylates	0.003	0.997	0.000
L90.9 Atrophic disorder of skin, unspecified	0.003	0.997	0.000
L90.8 Other atrophic disorders of skin	0.003	0.997	0.000
L90.6 Striae atrophicae	0.003	0.997	0.000
L90.4 Acrodermatitis chronica atrophicans	0.003	0.997	0.000
L90.3 Atrophoderma of Pasini and Pierini	0.003	0.997	0.000
L90.2 Anetoderma of Jadassohn-Pellizzari	0.003	0.997	0.000
L90.1 Anetoderma of Schweninger-Buzzi	0.003	0.997	0.000
R25 Abnormal involuntary movements	0.000	0.997	0.003
Chapter XX External causes of morbidity and mortality	0.003	0.997	0.000
Y86 Sequelae of other accidents	0.003	0.997	0.000
N31.2 Flaccid neuropathic bladder, not elsewhere classified	0.003	0.997	0.000
R25.1 Tremor, unspecified	0.000	0.997	0.003
X40-X49 Accidental poisoning by and exposure to noxious substances	0.003	0.997	0.000
R29.4 Clicking hip	0.000	0.997	0.003
R29.3 Abnormal posture	0.000	0.997	0.003
R29.2 Abnormal reflex	0.000	0.997	0.003
R29.1 Meningismus	0.000	0.997	0.003
R29.0 Tetany	0.000	0.997	0.003
Y57.5 X-ray contrast media	0.002	0.997	0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.003	0.997	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.003	0.997	0.000
Y43 Primarily systemic agents	0.003	0.997	0.000
M86.97 Osteomyelitis, unspecified (Ankle and foot)	0.003	0.997	0.000
R26.1 Paralytic gait	0.000	0.997	0.003
N31.1 Reflex neuropathic bladder, not elsewhere classified	0.003	0.997	0.000
N31.0 Uninhibited neuropathic bladder, not elsewhere classified	0.003	0.997	0.000
H10.9 Conjunctivitis, unspecified	0.003	0.997	0.000
I50 Heart failure	0.000	0.997	0.003
M86.9 Osteomyelitis, unspecified	0.003	0.997	0.000
X49 Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances	0.003	0.997	0.000
R26.3 Immobility	0.000	0.997	0.003
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.003	0.997	0.000
R25.3 Fasciculation	0.000	0.997	0.003
W75-W84 Other accidental threats to breathing	0.003	0.997	0.000
M72.09 Palmar fascial fibromatosis [Dupuytren]-Site unspec	0.002	0.997	0.000
M72.08 Palmar fascial fibromatosis [Dupuytren]-Other	0.002	0.997	0.000
M72.07 Palmar fascial fibromatosis [Dupuytren]-Ankle/Foot	0.002	0.997	0.000
M72.06 Palmar fascial fibromatosis [Dupuytren]-Lower Leg	0.002	0.997	0.000
M72.05 Palmar fascial fibromatosis [Dupuytren]-Pelvic/Thigh	0.002	0.997	0.000
M72.03 Palmar fascial fibromatosis [Dupuytren]-Forearm	0.002	0.997	0.000
M72.02 Palmar fascial fibromatosis [Dupuytren]-Upper arm	0.002	0.997	0.000
M72.01 Palmar fascial fibromatosis [Dupuytren]-Shldr region	0.002	0.997	0.000
M72.00 Palmar fascial fibromatosis [Dupuytren]-Mult sites	0.002	0.997	0.000
X49.9 Unspecified place	0.003	0.997	0.000
Y10-Y34 Event of undetermined intent	0.002	0.997	0.000
H60.9 Otitis externa, unspecified	0.002	0.997	0.001
S32.00 Fracture of lumbar vertebra (closed)	0.000	0.997	0.003
I21.1 Acute transmural myocardial infarction of inferior wall	0.003	0.997	0.000
W50-W64 Exposure to animate mechanical forces	0.003	0.997	0.000
R26.0 Ataxic gait	0.000	0.997	0.002
Y89 Sequelae of other external causes	0.002	0.997	0.000
X10-X19 Contact with heat and hot substances	0.002	0.997	0.000
R25.2 Cramp and spasm	0.000	0.997	0.003
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified	0.002	0.997	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.002	0.997	0.000
S42.90 Fracture of shoulder girdle, part unspecified (closed)	0.002	0.997	0.000
W22 Striking against or struck by other objects	0.002	0.997	0.000
W20-W49 Exposure to inanimate mechanical forces	0.002	0.997	0.000
M86.94 Osteomyelitis, unspecified (Hand)	0.002	0.998	0.000
S82.00 Fracture of patella (closed)	0.000	0.998	0.002
X20-X29 Contact with venomous animals and plants	0.002	0.998	0.000
V20-V29 Motorcycle rider injured in transport accident	0.002	0.998	0.000
M86.99 Osteomyelitis, unspecified (Site unspecified)	0.002	0.998	0.000
R25.0 Abnormal head movements	0.000	0.998	0.002
W13.9 Unspecified place	0.002	0.998	0.000
Y35-Y36 Legal intervention and operations of war	0.002	0.998	0.000
Y00-Y09 Assault	0.002	0.998	0.000
X85-X99 Assault	0.002	0.998	0.000
X30-X39 Exposure to forces of nature	0.002	0.998	0.000
X00-X09 Exposure to smoke, fire and flames	0.002	0.998	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.002	0.998	0.000
W65-W74 Accidental drowning and submersion	0.002	0.998	0.000
V98-V99 Other and unspecified transport accidents	0.002	0.998	0.000
V95-V97 Air and space transport accidents	0.002	0.998	0.000
V90-V94 Water transport accidents	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations