TreeWAS – Variant ID: rs17421627

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M25 Other joint disorders, not elsewhere classified	0.352	0.648	0.000
M25.7 Osteophyte	0.347	0.653	0.000
M25.8 Other specified joint disorders	0.341	0.659	0.000
M25.78 Osteophyte (Other)	0.336	0.664	0.000
M25.86 Other specified joint disorders (Lower leg)	0.320	0.680	0.000
M25.4 Effusion of joint	0.309	0.691	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.309	0.691	0.000
M25.84 Other specified joint disorders (Hand)	0.306	0.694	0.000
M25.74 Osteophyte (Hand)	0.298	0.702	0.000
M25.3 Other instability of joint	0.294	0.706	0.000
M25.46 Effusion of joint (Lower leg)	0.293	0.707	0.000
M25.72 Osteophyte (Upper arm)	0.289	0.711	0.000
M25.9 Joint disorder, unspecified	0.289	0.711	0.000
M20-M25 Other joint disorders	0.288	0.712	0.000
M25.71 Osteophyte (Shoulder region)	0.273	0.726	0.000
M25.81 Other specified joint disorders (Shoulder region)	0.271	0.729	0.000
M25.83 Other specified joint disorders (Forearm)	0.265	0.735	0.000
M23 Internal derangement of knee	0.263	0.737	0.000
M25.76 Osteophyte (Lower leg)	0.255	0.745	0.000
M24 Other specific joint derangements	0.255	0.745	0.000
M25.2 Flail joint	0.252	0.747	0.000
M25.1 Fistula of joint	0.252	0.747	0.000
M25.79 Osteophyte (Site unspecified)	0.249	0.751	0.000
M25.73 Osteophyte (Forearm)	0.249	0.751	0.000
M25.70 Osteophyte (Multiple sites)	0.249	0.751	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.249	0.751	0.000
M25.89 Other specified joint disorders (Site unspecified)	0.245	0.755	0.000
M25.88 Other specified joint disorders (Other)	0.245	0.755	0.000
M25.82 Other specified joint disorders (Upper arm)	0.245	0.755	0.000
M25.80 Other specified joint disorders (Multiple sites)	0.245	0.755	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.240	0.760	0.000
M25.36 Other instability of joint (Lower leg)	0.240	0.760	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.238	0.762	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.236	0.764	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.235	0.765	0.000
M23.4 Loose body in knee	0.235	0.765	0.000
M25.31 Other instability of joint (Shoulder region)	0.231	0.769	0.000
M25.96 Joint disorder, unspecified (Lower leg)	0.229	0.771	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.228	0.772	0.000
M25.94 Joint disorder, unspecified (Hand)	0.228	0.772	0.000
M25.0 Haemarthrosis	0.224	0.775	0.000
M23.2 Derangement of meniscus due to old tear or injury	0.224	0.776	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.223	0.777	0.000
M25.49 Effusion of joint (Site unspecified)	0.222	0.778	0.000
M25.48 Effusion of joint (Other)	0.222	0.778	0.000
M25.44 Effusion of joint (Hand)	0.222	0.778	0.000
M25.43 Effusion of joint (Forearm)	0.222	0.778	0.000
M25.42 Effusion of joint (Upper arm)	0.222	0.778	0.000
M25.41 Effusion of joint (Shoulder region)	0.222	0.778	0.000
M25.40 Effusion of joint (Multiple sites)	0.222	0.778	0.000
M86-M90 Other osteopathies	0.222	0.778	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.222	0.778	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.222	0.778	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.222	0.778	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.222	0.778	0.000
M24.2 Disorder of ligament	0.220	0.780	0.000
M25.45 Effusion of joint (Pelvic region and thigh)	0.218	0.782	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.217	0.782	0.000
M24.1 Other articular cartilage disorders	0.217	0.783	0.000
M25.37 Other instability of joint (Ankle and foot)	0.216	0.784	0.000
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.216	0.784	0.000
M23.49 Loose body in knee-Unspec lig/men	0.214	0.786	0.000
M05-M14 Inflammatory polyarthropathies	0.213	0.787	0.000
M35 Other systemic involvement of connective tissue	0.213	0.787	0.000
M80-M85 Disorders of bone density and structure	0.212	0.788	0.000
M86 Osteomyelitis	0.212	0.788	0.000
M25.39 Other instability of joint (Site unspecified)	0.211	0.789	0.000
M25.38 Other instability of joint (Other)	0.211	0.789	0.000
M25.35 Other instability of joint (Pelvic region and thigh)	0.211	0.789	0.000
M25.33 Other instability of joint (Forearm)	0.211	0.789	0.000
M25.32 Other instability of joint (Upper arm)	0.211	0.789	0.000
M25.30 Other instability of joint (Multiple sites)	0.211	0.789	0.000
M25.77 Osteophyte (Ankle and foot)	0.210	0.790	0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.210	0.790	0.000
M25.99 Joint disorder, unspecified (Site unspecified)	0.207	0.793	0.000
M25.98 Joint disorder, unspecified (Other)	0.207	0.793	0.000
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.207	0.793	0.000
M25.93 Joint disorder, unspecified (Forearm)	0.207	0.793	0.000
M25.92 Joint disorder, unspecified (Upper arm)	0.207	0.793	0.000
M25.91 Joint disorder, unspecified (Shoulder region)	0.207	0.793	0.000
M25.90 Joint disorder, unspecified (Multiple sites)	0.207	0.793	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.207	0.793	0.000
M32 Systemic lupus erythematosus	0.207	0.793	0.000
M33 Dermatopolymyositis	0.206	0.794	0.000
M25.97 Joint disorder, unspecified (Ankle and foot)	0.206	0.794	0.000
M25.34 Other instability of joint (Hand)	0.206	0.794	0.000
M30 Polyarteritis nodosa and related conditions	0.205	0.795	0.000
M22 Disorders of patella	0.204	0.796	0.000
M23.8 Other internal derangements of knee	0.204	0.796	0.000
M24.5 Contracture of joint	0.203	0.797	0.000
M25.87 Other specified joint disorders (Ankle and foot)	0.203	0.797	0.000
M31 Other necrotising vasculopathies	0.203	0.797	0.000
M23.3 Other meniscus derangements	0.196	0.804	0.000
M60-M63 Disorders of muscles	0.195	0.805	0.000
M34 Systemic sclerosis	0.195	0.805	0.000
M86.9 Osteomyelitis, unspecified	0.194	0.806	0.000
M84 Disorders of continuity of bone	0.193	0.807	0.000
M23.0 Cystic meniscus	0.189	0.810	0.000
M13 Other arthritis	0.189	0.811	0.000
M06 Other rheumatoid arthritis	0.189	0.811	0.000
M22.4 Chondromalacia patellae	0.189	0.811	0.000
M23.1 Discoid meniscus (congenital)	0.189	0.811	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.188	0.812	0.000
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.187	0.813	0.000
H25.9 Senile cataract, unspecified	0.000	0.814	0.186
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)	0.185	0.815	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.184	0.816	0.000
M85 Other disorders of bone density and structure	0.184	0.816	0.000
M24.9 Joint derangement, unspecified	0.183	0.817	0.000
M24.7 Protrusio acetabuli	0.183	0.817	0.000
M24.6 Ankylosis of joint	0.183	0.817	0.000
M45-M49 Spondylopathies	0.183	0.817	0.000
M24.17 Other articular cartilage disorders (Ankle and foot)	0.182	0.818	0.000
M24.26 Disorder of ligament (Lower leg)	0.182	0.818	0.000
M70-M79 Other soft tissue disorders	0.182	0.818	0.000
M25.19 Fistula of joint (Site unspecified)	0.181	0.819	0.000
M25.18 Fistula of joint (Other)	0.181	0.819	0.000
M25.17 Fistula of joint (Ankle and foot)	0.181	0.819	0.000
M25.16 Fistula of joint (Lower leg)	0.181	0.819	0.000
M25.15 Fistula of joint (Pelvic region and thigh)	0.181	0.819	0.000
M25.14 Fistula of joint (Hand)	0.181	0.819	0.000
M25.13 Fistula of joint (Forearm)	0.181	0.819	0.000
M25.12 Fistula of joint (Upper arm)	0.181	0.819	0.000
M25.11 Fistula of joint (Shoulder region)	0.181	0.819	0.000
M25.10 Fistula of joint (Multiple sites)	0.181	0.819	0.000
M25.29 Flail joint (Site unspecified)	0.181	0.819	0.000
M25.28 Flail joint (Other)	0.181	0.819	0.000
M25.27 Flail joint (Ankle and foot)	0.181	0.819	0.000
M25.26 Flail joint (Lower leg)	0.181	0.819	0.000
M25.25 Flail joint (Pelvic region and thigh)	0.181	0.819	0.000
M25.24 Flail joint (Hand)	0.181	0.819	0.000
M25.23 Flail joint (Forearm)	0.181	0.819	0.000
M25.22 Flail joint (Upper arm)	0.181	0.819	0.000
M25.21 Flail joint (Shoulder region)	0.181	0.819	0.000
M25.20 Flail joint (Multiple sites)	0.181	0.819	0.000
H25.1 Senile nuclear cataract	0.000	0.819	0.181
M35.7 Hypermobility syndrome	0.180	0.820	0.000
M23.5 Chronic instability of knee	0.180	0.820	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.179	0.821	0.000
M23.82 Other internal derangements of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.177	0.822	0.000
H25 Senile cataract	0.000	0.823	0.177
M86.6 Other chronic osteomyelitis	0.177	0.823	0.000
M23.9 Internal derangement of knee, unspecified	0.176	0.823	0.000
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)	0.174	0.826	0.000
M90 Osteopathies in diseases classified elsewhere	0.173	0.827	0.000
M86.97 Osteomyelitis, unspecified (Ankle and foot)	0.172	0.828	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.172	0.828	0.000
M35.1 Other overlap syndromes	0.172	0.828	0.000
M65-M68 Disorders of synovium and tendon	0.171	0.829	0.000
M23.86 Other internal derangements of knee (Other and unspecified lateral meniscus)	0.171	0.829	0.000
M86.1 Other acute osteomyelitis	0.170	0.829	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.170	0.830	0.000
M13.9 Arthritis, unspecified	0.169	0.831	0.000
M24.24 Disorder of ligament (Hand)	0.169	0.831	0.000
M23.47 Loose body in knee-Capsular lig	0.168	0.832	0.000
M23.46 Loose body in knee-O/unsp lat men	0.168	0.832	0.000
M23.45 Loose body in knee-Pst hrn lat men	0.168	0.832	0.000
M23.44 Loose body in knee-Lat lig/ant men	0.168	0.832	0.000
M23.43 Loose body in knee-Med lig/oth men	0.168	0.832	0.000
M23.42 Loose body in knee-Pst lig/hrn men	0.168	0.832	0.000
M23.41 Loose body in knee-Ant lig/hrn men	0.168	0.832	0.000
M23.40 Loose body in knee-Mult sites	0.168	0.832	0.000
M24.23 Disorder of ligament (Forearm)	0.167	0.832	0.000
M23.39 Other meniscus derangements (Unspecified ligament or Unspecified meniscus)	0.167	0.833	0.000
M62 Other disorders of muscle	0.166	0.833	0.000
M23.6 Other spontaneous disruption of ligament(s) of knee	0.166	0.834	0.000
M00-M03 Infectious arthropathies	0.165	0.835	0.000
M79.0 Rheumatism, unspecified	0.164	0.836	0.000
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.164	0.836	0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.163	0.837	0.000
M40-M43 Deforming dorsopathies	0.163	0.837	0.000
M06.3 Rheumatoid nodule	0.162	0.838	0.000
M24.0 Loose body in joint	0.162	0.838	0.000
M25.09 Haemarthrosis (Site unspecified)	0.161	0.839	0.000
M25.08 Haemarthrosis (Other)	0.161	0.839	0.000
M25.07 Haemarthrosis (Ankle and foot)	0.161	0.839	0.000
M25.05 Haemarthrosis (Pelvic region and thigh)	0.161	0.839	0.000
M25.04 Haemarthrosis (Hand)	0.161	0.839	0.000
M25.03 Haemarthrosis (Forearm)	0.161	0.839	0.000
M25.02 Haemarthrosis (Upper arm)	0.161	0.839	0.000
M25.01 Haemarthrosis (Shoulder region)	0.161	0.839	0.000
M25.00 Haemarthrosis (Multiple sites)	0.161	0.839	0.000
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.161	0.839	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.161	0.839	0.000
M07 Psoriatic and enteropathic arthropathies	0.161	0.839	0.000
M24.27 Disorder of ligament (Ankle and foot)	0.160	0.840	0.000
M86.99 Osteomyelitis, unspecified (Site unspecified)	0.160	0.840	0.000
M24.54 Contracture of joint (Hand)	0.159	0.841	0.000
M25.47 Effusion of joint (Ankle and foot)	0.159	0.841	0.000
M06.0 Seronegative rheumatoid arthritis	0.159	0.841	0.000
M82 Osteoporosis in diseases classified elsewhere	0.159	0.841	0.000
M21 Other acquired deformities of limbs	0.159	0.841	0.000
M35.0 Sicca syndrome [Sjogren]	0.159	0.841	0.000
M88 Paget's disease of bone [osteitis deformans]	0.158	0.842	0.000
M11 Other crystal arthropathies	0.158	0.842	0.000
M14 Arthropathies in other diseases classified elsewhere	0.158	0.842	0.000
M24.29 Disorder of ligament (Site unspecified)	0.158	0.842	0.000
M24.28 Disorder of ligament (Other)	0.158	0.842	0.000
M24.25 Disorder of ligament (Pelvic region and thigh)	0.158	0.842	0.000
M24.22 Disorder of ligament (Upper arm)	0.158	0.842	0.000
M24.21 Disorder of ligament (Shoulder region)	0.158	0.842	0.000
M24.20 Disorder of ligament (Multiple sites)	0.158	0.842	0.000
M91-M94 Chondropathies	0.157	0.843	0.000
M13.98 Arthritis, unspecified (Other)	0.157	0.843	0.000
M24.19 Other articular cartilage disorders (Site unspecified)	0.156	0.844	0.000
M24.18 Other articular cartilage disorders (Other)	0.156	0.844	0.000
M24.14 Other articular cartilage disorders (Hand)	0.156	0.844	0.000
M24.12 Other articular cartilage disorders (Upper arm)	0.156	0.844	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.156	0.844	0.000
M24.10 Other articular cartilage disorders (Multiple sites)	0.156	0.844	0.000
M87 Osteonecrosis	0.155	0.844	0.000
M13.99 Arthritis, unspecified (Site unspecified)	0.155	0.845	0.000
M79.09 Rheumatism, unspecified (Site unspecified)	0.155	0.845	0.000
M24.56 Contracture of joint (Lower leg)	0.155	0.845	0.000
M24.13 Other articular cartilage disorders (Forearm)	0.155	0.845	0.000
M34.8 Other forms of systemic sclerosis	0.153	0.846	0.000
M12 Other specific arthropathies	0.153	0.847	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.153	0.847	0.000
M08 Juvenile arthritis	0.153	0.847	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.152	0.847	0.000
M35.8 Other specified systemic involvement of connective tissue	0.152	0.847	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.152	0.847	0.000
M35.5 Multifocal fibrosclerosis	0.152	0.847	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.152	0.847	0.000
M35.2 Behcet's disease	0.152	0.847	0.000
M83 Adult osteomalacia	0.152	0.848	0.000
M86.67 Other chronic osteomyelitis (Ankle and foot)	0.152	0.848	0.000
M86.8 Other osteomyelitis	0.152	0.848	0.000
M86.5 Other chronic haematogenous osteomyelitis	0.152	0.848	0.000
M86.4 Chronic osteomyelitis with draining sinus	0.152	0.848	0.000
M86.3 Chronic multifocal osteomyelitis	0.152	0.848	0.000
M86.2 Subacute osteomyelitis	0.152	0.848	0.000
M86.0 Acute haematogenous osteomyelitis	0.152	0.848	0.000
M89 Other disorders of bone	0.152	0.848	0.000
M84.8 Other disorders of continuity of bone	0.150	0.850	0.000
M71 Other bursopathies	0.150	0.850	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.149	0.850	0.000
M23.35 Other meniscus derangements (Posterior horn of lateral meniscus)	0.149	0.851	0.000
M84.0 Malunion of fracture	0.149	0.851	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.148	0.851	0.000
M32.8 Other forms of systemic lupus erythematosus	0.148	0.851	0.000
M32.1 Systemic lupus erythematosus with organ or system involvement	0.148	0.851	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.148	0.851	0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.148	0.851	0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.148	0.851	0.000
M36.3 Arthropathy in other blood disorders	0.148	0.851	0.000
M36.2 Haemophilic arthropathy	0.148	0.851	0.000
M36.1 Arthropathy in neoplastic disease	0.148	0.851	0.000
M36.0 Dermato(poly)myositis in neoplastic disease	0.148	0.851	0.000
M47 Spondylosis	0.148	0.852	0.000
M33.9 Dermatopolymyositis, unspecified	0.148	0.852	0.000
M33.2 Polymyositis	0.148	0.852	0.000
M33.0 Juvenile dermatomyositis	0.148	0.852	0.000
M23.31 Other meniscus derangements (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.148	0.852	0.000
M85.8 Other specified disorders of bone density and structure	0.147	0.853	0.000
M33.1 Other dermatomyositis	0.147	0.853	0.000
M31.3 Wegener's granulomatosis	0.147	0.853	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.147	0.853	0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.147	0.853	0.000
M30.2 Juvenile polyarteritis	0.147	0.853	0.000
M30.0 Polyarteritis nodosa	0.147	0.853	0.000
M85.0 Fibrous dysplasia (monostotic)	0.147	0.853	0.000
M23.33 Other meniscus derangements (Medial collateral ligament or Other and unspecified medial meniscus)	0.147	0.853	0.000
M22.1 Recurrent subluxation of patella	0.147	0.853	0.000
M22.9 Disorder of patella, unspecified	0.147	0.853	0.000
M22.0 Recurrent dislocation of patella	0.147	0.853	0.000
M23.87 Other internal derangements of knee (Capsular ligament)	0.147	0.853	0.000
M23.85 Other internal derangements of knee (Posterior horn of lateral meniscus)	0.147	0.853	0.000
M23.84 Other internal derangements of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.147	0.853	0.000
M79.7 Fibromyalgia	0.147	0.853	0.000
M62.8 Other specified disorders of muscle	0.146	0.854	0.000
M25.5 Pain in joint	0.146	0.854	0.000
M24.59 Contracture of joint (Site unspecified)	0.146	0.854	0.000
M24.58 Contracture of joint (Other)	0.146	0.854	0.000
M24.57 Contracture of joint (Ankle and foot)	0.146	0.854	0.000
M24.55 Contracture of joint (Pelvic region and thigh)	0.146	0.854	0.000
M24.53 Contracture of joint (Forearm)	0.146	0.854	0.000
M24.52 Contracture of joint (Upper arm)	0.146	0.854	0.000
M24.51 Contracture of joint (Shoulder region)	0.146	0.854	0.000
M24.50 Contracture of joint (Multiple sites)	0.146	0.854	0.000
M31.9 Necrotising vasculopathy, unspecified	0.145	0.854	0.000
M31.8 Other specified necrotising vasculopathies	0.145	0.854	0.000
M31.7 Microscopic polyangiitis	0.145	0.854	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.145	0.854	0.000
M31.2 Lethal midline granuloma	0.145	0.854	0.000
M31.1 Thrombotic microangiopathy	0.145	0.854	0.000
M31.0 Hypersensitivity angiitis	0.145	0.854	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.145	0.855	0.000
M23.83 Other internal derangements of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.145	0.855	0.000
M46 Other inflammatory spondylopathies	0.145	0.855	0.000
M06.9 Rheumatoid arthritis, unspecified	0.144	0.856	0.000
M23.80 Other internal derangements of knee (Multiple sites)	0.144	0.856	0.000
M85.6 Other cyst of bone	0.143	0.857	0.000
M79.1 Myalgia	0.143	0.857	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.142	0.858	0.000
M25.50 Pain in joint (Multiple sites)	0.142	0.858	0.000
M13.8 Other specified arthritis	0.141	0.859	0.000
M86.17 Other acute osteomyelitis (Ankle and foot)	0.141	0.859	0.000
M23.37 Other meniscus derangements-Capsular lig	0.140	0.860	0.000
M24.37 Pathological dislocation and subluxation of joint, not elsewhere classified (Ankle and foot)	0.140	0.860	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.140	0.860	0.000
M61 Calcification and ossification of muscle	0.140	0.860	0.000
M60 Myositis	0.140	0.860	0.000
M23.06 Cystic meniscus (Other and unspecified lateral meniscus)	0.140	0.860	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.140	0.860	0.000
M34.0 Progressive systemic sclerosis	0.140	0.860	0.000
M13.0 Polyarthritis, unspecified	0.139	0.861	0.000
M86.98 Osteomyelitis, unspecified (Other)	0.139	0.861	0.000
M86.96 Osteomyelitis, unspecified (Lower leg)	0.139	0.861	0.000
M86.95 Osteomyelitis, unspecified (Pelvic region and thigh)	0.139	0.861	0.000
M86.94 Osteomyelitis, unspecified (Hand)	0.139	0.861	0.000
M86.93 Osteomyelitis, unspecified (Forearm)	0.139	0.861	0.000
M86.92 Osteomyelitis, unspecified (Upper arm)	0.139	0.861	0.000
M86.91 Osteomyelitis, unspecified (Shoulder region)	0.139	0.861	0.000
M86.90 Osteomyelitis, unspecified (Multiple sites)	0.139	0.861	0.000
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)	0.139	0.861	0.000
M66 Spontaneous rupture of synovium and tendon	0.139	0.861	0.000
M76 Enthesopathies of lower limb, excluding foot	0.139	0.861	0.000
M84.9 Disorder of continuity of bone, unspecified	0.138	0.861	0.000
M84.4 Pathological fracture, not elsewhere classified	0.138	0.861	0.000
M84.3 Stress fracture, not elsewhere classified	0.138	0.861	0.000
M84.2 Delayed union of fracture	0.138	0.861	0.000
M65 Synovitis and tenosynovitis	0.138	0.862	0.000
M84.17 Nonunion of fracture [pseudarthrosis] (Ankle and foot)	0.138	0.862	0.000
M90.7 Fracture of bone in neoplastic disease	0.138	0.862	0.000
M79.2 Neuralgia and neuritis, unspecified	0.137	0.863	0.000
M45 Ankylosing spondylitis	0.136	0.864	0.000
M23.34 Other meniscus derangements (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.136	0.864	0.000
M23.09 Cystic meniscus (Unspecified ligament or Unspecified meniscus)	0.136	0.864	0.000
M23.07 Cystic meniscus-Capsular lig	0.136	0.864	0.000
M23.05 Cystic meniscus (Posterior horn of lateral meniscus)	0.136	0.864	0.000
M23.04 Cystic meniscus (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.136	0.864	0.000
M23.02 Cystic meniscus (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.136	0.864	0.000
M23.01 Cystic meniscus (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.136	0.864	0.000
M23.00 Cystic meniscus (Multiple sites)	0.136	0.864	0.000
M13.1 Monoarthritis, not elsewhere classified	0.136	0.864	0.000
M06.8 Other specified rheumatoid arthritis	0.136	0.864	0.000
M06.2 Rheumatoid bursitis	0.136	0.864	0.000
M06.1 Adult-onset Still's disease	0.136	0.864	0.000
M23.19 Discoid meniscus (congenital) (Unspecified ligament or Unspecified meniscus)	0.135	0.864	0.000
M23.17 Discoid meniscus (congenital)-Capsular lig	0.135	0.864	0.000
M23.16 Discoid meniscus (congenital) (Other and unspecified lateral meniscus)	0.135	0.864	0.000
M23.15 Discoid meniscus (congenital) (Posterior horn of lateral meniscus)	0.135	0.864	0.000
M23.14 Discoid meniscus (congenital) (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.135	0.864	0.000
M23.13 Discoid meniscus (congenital) (Medial collateral ligament or Other and unspecified medial meniscus)	0.135	0.864	0.000
M23.12 Discoid meniscus (congenital) (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.135	0.864	0.000
M23.11 Discoid meniscus (congenital) (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.135	0.864	0.000
M23.10 Discoid meniscus (congenital) (Multiple sites)	0.135	0.864	0.000
H25-H28 Disorders of lens	0.000	0.864	0.136
M24.39 Pathological dislocation and subluxation of joint, not elsewhere classified (Site unspecified)	0.135	0.865	0.000
M24.38 Pathological dislocation and subluxation of joint, not elsewhere classified (Other)	0.135	0.865	0.000
M24.36 Pathological dislocation and subluxation of joint, not elsewhere classified (Lower leg)	0.135	0.865	0.000
M24.35 Pathological dislocation and subluxation of joint, not elsewhere classified (Pelvic region and thigh)	0.135	0.865	0.000
M24.34 Pathological dislocation and subluxation of joint, not elsewhere classified (Hand)	0.135	0.865	0.000
M24.33 Pathological dislocation and subluxation of joint, not elsewhere classified (Forearm)	0.135	0.865	0.000
M24.32 Pathological dislocation and subluxation of joint, not elsewhere classified (Upper arm)	0.135	0.865	0.000
M24.31 Pathological dislocation and subluxation of joint, not elsewhere classified (Shoulder region)	0.135	0.865	0.000
M24.30 Pathological dislocation and subluxation of joint, not elsewhere classified (Multiple sites)	0.135	0.865	0.000
M47.8 Other spondylosis	0.134	0.866	0.000
M25.06 Haemarthrosis (Lower leg)	0.133	0.867	0.000
M79.00 Rheumatism, unspecified (Multiple sites)	0.133	0.867	0.000
M23.03 Cystic meniscus (Medial collateral ligament or Other and unspecified medial meniscus)	0.133	0.867	0.000
M05 Seropositive rheumatoid arthritis	0.132	0.868	0.000
M85.9 Disorder of bone density and structure, unspecified	0.132	0.868	0.000
M85.5 Aneurysmal bone cyst	0.132	0.868	0.000
M85.4 Solitary bone cyst	0.132	0.868	0.000
M85.3 Osteitis condensans	0.132	0.868	0.000
M85.2 Hyperostosis of skull	0.132	0.868	0.000
M85.1 Skeletal fluorosis	0.132	0.868	0.000
M81 Osteoporosis without pathological fracture	0.132	0.868	0.000
M79.9 Soft tissue disorder, unspecified	0.132	0.868	0.000
M24.69 Ankylosis of joint (Site unspecified)	0.131	0.869	0.000
M24.68 Ankylosis of joint (Other)	0.131	0.869	0.000
M24.67 Ankylosis of joint (Ankle and foot)	0.131	0.869	0.000
M24.66 Ankylosis of joint (Lower leg)	0.131	0.869	0.000
M24.65 Ankylosis of joint (Pelvic region and thigh)	0.131	0.869	0.000
M24.64 Ankylosis of joint (Hand)	0.131	0.869	0.000
M24.63 Ankylosis of joint (Forearm)	0.131	0.869	0.000
M24.62 Ankylosis of joint (Upper arm)	0.131	0.869	0.000
M24.61 Ankylosis of joint (Shoulder region)	0.131	0.869	0.000
M24.60 Ankylosis of joint (Multiple sites)	0.131	0.869	0.000
M24.79 Protrusio acetabuli-Site unspec	0.131	0.869	0.000
M24.78 Protrusio acetabuli-Other	0.131	0.869	0.000
M24.77 Protrusio acetabuli-Ankle/foot	0.131	0.869	0.000
M24.76 Protrusio acetabuli-Lower leg	0.131	0.869	0.000
M24.75 Protrusio acetabuli-Pelvic/thigh	0.131	0.869	0.000
M24.74 Protrusio acetabuli-Hand	0.131	0.869	0.000
M24.73 Protrusio acetabuli-Forearm	0.131	0.869	0.000
M24.72 Protrusio acetabuli-Upper arm	0.131	0.869	0.000
M24.71 Protrusio acetabuli-Shldr region	0.131	0.869	0.000
M24.70 Protrusio acetabuli-Mult sites	0.131	0.869	0.000
M24.99 Joint derangement, unspecified (Site unspecified)	0.131	0.869	0.000
M24.98 Joint derangement, unspecified (Other)	0.131	0.869	0.000
M24.97 Joint derangement, unspecified (Ankle and foot)	0.131	0.869	0.000
M24.96 Joint derangement, unspecified (Lower leg)	0.131	0.869	0.000
M24.95 Joint derangement, unspecified (Pelvic region and thigh)	0.131	0.869	0.000
M24.94 Joint derangement, unspecified (Hand)	0.131	0.869	0.000
M24.93 Joint derangement, unspecified (Forearm)	0.131	0.869	0.000
M24.92 Joint derangement, unspecified (Upper arm)	0.131	0.869	0.000
M24.91 Joint derangement, unspecified (Shoulder region)	0.131	0.869	0.000
M24.90 Joint derangement, unspecified (Multiple sites)	0.131	0.869	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.131	0.869	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.130	0.870	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.130	0.870	0.000
M84.12 Nonunion of fracture [pseudarthrosis] (Upper arm)	0.130	0.870	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.130	0.870	0.000
M71.2 Synovial cyst of popliteal space [Baker]	0.130	0.870	0.000
M24.16 Other articular cartilage disorders (Lower leg)	0.130	0.870	0.000
M23.30 Other meniscus derangements (Multiple sites)	0.129	0.871	0.000
M23.59 Chronic instability of knee (Unspecified ligament or Unspecified meniscus)	0.129	0.871	0.000
M23.57 Chronic instability of knee (Capsular ligament)	0.129	0.871	0.000
M23.56 Chronic instability of knee (Other and unspecified lateral meniscus)	0.129	0.871	0.000
M23.55 Chronic instability of knee (Posterior horn of lateral meniscus)	0.129	0.871	0.000
M23.54 Chronic instability of knee (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.129	0.871	0.000
M23.53 Chronic instability of knee (Medial collateral ligament or Other and unspecified medial meniscus)	0.129	0.871	0.000
M23.52 Chronic instability of knee (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.129	0.871	0.000
M23.50 Chronic instability of knee (Multiple sites)	0.129	0.871	0.000
M49 Spondylopathies in diseases classified elsewhere	0.129	0.871	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.129	0.871	0.000
M13.90 Arthritis, unspecified (Multiple sites)	0.128	0.872	0.000
M24.89 Other specific joint derangements, not elsewhere classified (Site unspecified)	0.128	0.872	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.128	0.872	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.128	0.872	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.128	0.872	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.128	0.872	0.000
M24.81 Other specific joint derangements, not elsewhere classified (Shoulder region)	0.128	0.872	0.000
M24.80 Other specific joint derangements, not elsewhere classified (Multiple sites)	0.128	0.872	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.128	0.872	0.000
H25.2 Senile cataract, morgagnian type	0.000	0.872	0.127
M86.69 Other chronic osteomyelitis (Site unspecified)	0.127	0.873	0.000
M86.68 Other chronic osteomyelitis (Other)	0.127	0.873	0.000
M86.66 Other chronic osteomyelitis (Lower leg)	0.127	0.873	0.000
M86.65 Other chronic osteomyelitis (Pelvic region and thigh)	0.127	0.873	0.000
M86.64 Other chronic osteomyelitis (Hand)	0.127	0.873	0.000
M86.63 Other chronic osteomyelitis (Forearm)	0.127	0.873	0.000
M86.62 Other chronic osteomyelitis (Upper arm)	0.127	0.873	0.000
M86.61 Other chronic osteomyelitis (Shoulder region)	0.127	0.873	0.000
M86.60 Other chronic osteomyelitis (Multiple sites)	0.127	0.873	0.000
M34.1 CR(E)ST syndrome	0.127	0.873	0.000
M13.97 Arthritis, unspecified (Ankle and foot)	0.127	0.873	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.127	0.873	0.000
M23.97 Internal derangement of knee, unspecified (Capsular ligament)	0.127	0.873	0.000
M23.96 Internal derangement of knee, unspecified (Other and unspecified lateral meniscus)	0.127	0.873	0.000
M23.95 Internal derangement of knee, unspecified (Posterior horn of lateral meniscus)	0.127	0.873	0.000
M23.94 Internal derangement of knee, unspecified (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.127	0.873	0.000
M23.93 Internal derangement of knee, unspecified (Medial collateral ligament or Other and unspecified medial meniscus)	0.127	0.873	0.000
M23.92 Internal derangement of knee, unspecified (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.127	0.873	0.000
M23.91 Internal derangement of knee, unspecified (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.127	0.873	0.000
M23.90 Internal derangement of knee, unspecified (Multiple sites)	0.127	0.873	0.000
H26 Other cataract	0.000	0.873	0.127
M80 Osteoporosis with pathological fracture	0.127	0.873	0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.127	0.873	0.000
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.127	0.873	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.126	0.874	0.000
M79.5 Residual foreign body in soft tissue	0.125	0.875	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.125	0.875	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.125	0.875	0.000
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.125	0.875	0.000
M90.8 Osteopathy in other diseases classified elsewhere	0.124	0.876	0.000
M90.6 Osteitis deformans in neoplastic disease	0.124	0.876	0.000
M90.5 Osteonecrosis in other diseases classified elsewhere	0.124	0.876	0.000
M90.4 Osteonecrosis due to heamoglobinopathy	0.124	0.876	0.000
M90.3 Osteonecrosis in caisson disease	0.124	0.876	0.000
M90.2 Osteopathy in other infectious diseases classified elsewhere	0.124	0.876	0.000
M90.1 Periostitis in other infectious diseases classified elsewhere	0.124	0.876	0.000
M90.0 Tuberculosis of bone	0.124	0.876	0.000
M79.10 Myalgia (Multiple sites)	0.124	0.876	0.000
M24.85 Other specific joint derangements, not elsewhere classified (Pelvic region and thigh)	0.124	0.876	0.000
M79.4 Hypertrophy of (infrapatellar) fat pad	0.124	0.876	0.000
M79.3 Panniculitis, unspecified	0.124	0.876	0.000
M46.2 Osteomyelitis of vertebra	0.123	0.876	0.000
M13.96 Arthritis, unspecified (Lower leg)	0.124	0.876	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.123	0.877	0.000
M47.86 Other spondylosis (Lumbar region)	0.123	0.877	0.000
M79.79 Fibromyalgia (Site unspecified)	0.123	0.877	0.000
M07.3 Other psoriatic arthropathies	0.123	0.877	0.000
M34.9 Systemic sclerosis, unspecified	0.122	0.877	0.000
M86.19 Other acute osteomyelitis (Site unspecified)	0.122	0.877	0.000
M86.18 Other acute osteomyelitis (Other)	0.122	0.877	0.000
M86.16 Other acute osteomyelitis (Lower leg)	0.122	0.877	0.000
M86.15 Other acute osteomyelitis (Pelvic region and thigh)	0.122	0.877	0.000
M86.14 Other acute osteomyelitis (Hand)	0.122	0.877	0.000
M86.13 Other acute osteomyelitis (Forearm)	0.122	0.877	0.000
M86.12 Other acute osteomyelitis (Upper arm)	0.122	0.877	0.000
M86.11 Other acute osteomyelitis (Shoulder region)	0.122	0.877	0.000
M86.10 Other acute osteomyelitis (Multiple sites)	0.122	0.877	0.000
M84.19 Nonunion of fracture [pseudarthrosis] (Site unspecified)	0.122	0.878	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.122	0.878	0.000
M84.10 Nonunion of fracture [pseudarthrosis] (Multiple sites)	0.122	0.878	0.000
M25.54 Pain in joint (Hand)	0.122	0.878	0.000
H26.9 Cataract, unspecified	0.000	0.878	0.122
M13.92 Arthritis, unspecified (Upper arm)	0.122	0.878	0.000
M89.3 Hypertrophy of bone	0.122	0.878	0.000
M24.02 Loose body in joint (Upper arm)	0.121	0.879	0.000
M43 Other deforming dorsopathies	0.121	0.879	0.000
M62.88 Other specified disorders of muscle (Other)	0.121	0.879	0.000
M82.1 Osteoporosis in endocrine disorders	0.120	0.879	0.000
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.120	0.880	0.000
M40 Kyphosis and lordosis	0.120	0.880	0.000
M23.51 Chronic instability of knee (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.120	0.880	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations