TreeWAS – Variant ID: rs191655746

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
M20-M25 Other joint disorders	0.999	0.001
M54 Dorsalgia	0.999	0.001
M50-M54 Other dorsopathies	0.998	0.002
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.998	0.002
M20 Acquired deformities of fingers and toes	0.996	0.004
M54.5 Low back pain	0.988	0.012
M25 Other joint disorders, not elsewhere classified	0.983	0.017
M54.3 Sciatica	0.974	0.026
M54.9 Dorsalgia, unspecified	0.974	0.026
M20.1 Hallux valgus (acquired)	0.961	0.039
M54.59 Low back pain (Site unspecified)	0.950	0.050
M20.5 Other deformities of toe(s) (acquired)	0.947	0.053
M54.99 Dorsalgia, unspecified (Site unspecified)	0.947	0.053
M54.39 Sciatica (Site unspecified)	0.928	0.072
M23 Internal derangement of knee	0.926	0.074
M54.58 Low back pain (Sacral and sacrococcygeal region)	0.898	0.102
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.894	0.106
M25.5 Pain in joint	0.894	0.106
M23.2 Derangement of meniscus due to old tear or injury	0.876	0.124
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.875	0.125
# Top node	0.872	0.128
M25.4 Effusion of joint	0.871	0.129
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.870	0.130
M20.4 Other hammer toe(s) (acquired)	0.870	0.130
M54.1 Radiculopathy	0.858	0.142
Chapter V Mental and behavioural disorders	0.843	0.157
M54.56 Low back pain (Lumbar region)	0.832	0.167
M54.37 Sciatica (Lumbosacral region)	0.831	0.169
M21 Other acquired deformities of limbs	0.830	0.170
S00-S09 Injuries to the head	0.827	0.173
M80-M85 Disorders of bone density and structure	0.821	0.179
M25.7 Osteophyte	0.816	0.184
S80-S89 Injuries to the knee and lower leg	0.811	0.189
M31 Other necrotising vasculopathies	0.810	0.190
S40-S49 Injuries to the shoulder and upper arm	0.806	0.194
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.799	0.201
F30-F39 Mood [affective] disorders	0.799	0.201
M25.8 Other specified joint disorders	0.793	0.207
M22 Disorders of patella	0.791	0.209
M25.46 Effusion of joint (Lower leg)	0.790	0.210
M20.2 Hallux rigidus	0.787	0.213
M54.96 Dorsalgia, unspecified (Lumbar region)	0.784	0.216
T84.0 Mechanical complication of internal joint prosthesis	0.782	0.218
M25.56 Pain in joint (Lower leg)	0.771	0.228
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.771	0.229
M24 Other specific joint derangements	0.770	0.230
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.768	0.232
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.766	0.234
M25.6 Stiffness of joint, not elsewhere classified	0.763	0.237
M54.36 Sciatica (Lumbar region)	0.762	0.238
M23.23 Derangement of meniscus due to old tear or injury (Medial collateral ligament or Other and unspecified medial meniscus)	0.762	0.238
M20.6 Acquired deformity of toe(s), unspecified	0.760	0.240
S70-S79 Injuries to the hip and thigh	0.757	0.243
Chapter XXI Factors influencing health status and contact with health services	0.755	0.245
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.754	0.246
M23.20 Derangement of meniscus due to old tear or injury (Multiple sites)	0.750	0.250
Z00-Z13 Persons encountering health services for examination and investigation	0.750	0.250
F10 Mental and behavioural disorders due to use of alcohol	0.749	0.251
S09 Other and unspecified injuries of head	0.747	0.253
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms	0.741	0.259
M34 Systemic sclerosis	0.741	0.259
M86-M90 Other osteopathies	0.741	0.259
M25.54 Pain in joint (Hand)	0.737	0.263
M53 Other dorsopathies, not elsewhere classified	0.734	0.266
M23.22 Derangement of meniscus due to old tear or injury (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.731	0.269
Z09.2 Follow-up examination after chemotherapy for other conditions	0.730	0.270
S60-S69 Injuries to the wrist and hand	0.727	0.272
S82 Fracture of lower leg, including ankle	0.726	0.274
M54.17 Radiculopathy (Lumbosacral region)	0.723	0.277
M25.55 Pain in joint (Pelvic region and thigh)	0.722	0.278
M23.26 Derangement of meniscus due to old tear or injury (Other and unspecified lateral meniscus)	0.717	0.283
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.716	0.283
M33 Dermatopolymyositis	0.716	0.283
M32 Systemic lupus erythematosus	0.716	0.283
M30 Polyarteritis nodosa and related conditions	0.716	0.283
M54.8 Other dorsalgia	0.716	0.284
M54.6 Pain in thoracic spine	0.716	0.284
M54.0 Panniculitis affecting regions of neck and back	0.716	0.284
M91-M94 Chondropathies	0.715	0.285
M60-M63 Disorders of muscles	0.715	0.285
M00-M03 Infectious arthropathies	0.715	0.285
M20.3 Other deformity of hallux (acquired)	0.714	0.286
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.713	0.287
M25.57 Pain in joint (Ankle and foot)	0.710	0.290
S80 Superficial injury of lower leg	0.710	0.290
M54.55 Low back pain (Thoracolumbar region)	0.709	0.291
M54.54 Low back pain-Thoracic	0.709	0.291
M54.53 Low back pain-Cervicothoracic	0.709	0.291
M54.52 Low back pain-Cervical	0.709	0.291
M54.51 Low back pain-Occipit-atl-axl	0.709	0.291
M54.50 Low back pain (Multiple sites in spine)	0.709	0.291
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.707	0.293
F10.0 Acute intoxication	0.706	0.294
M25.9 Joint disorder, unspecified	0.705	0.295
M25.3 Other instability of joint	0.705	0.295
M25.2 Flail joint	0.705	0.295
M25.1 Fistula of joint	0.705	0.295
M25.0 Haemarthrosis	0.705	0.295
F32 Depressive episode	0.702	0.298
F10.2 Dependence syndrome	0.701	0.299
T84.1 Mechanical complication of internal fixation device of bones of limb	0.701	0.299
T79-T79 Certain early complications of trauma	0.700	0.300
S42 Fracture of shoulder and upper arm	0.698	0.302
M54.38 Sciatica (Sacral and sacrococcygeal region)	0.698	0.302
M54.35 Sciatica (Thoracolumbar region)	0.698	0.302
M54.34 Sciatica-Thoracic	0.698	0.302
M54.33 Sciatica-Cervicothoracic	0.698	0.302
M54.32 Sciatica-Cervical	0.698	0.302
M54.31 Sciatica-Occipit-atl-axl	0.698	0.302
M54.30 Sciatica (Multiple sites in spine)	0.698	0.302
M54.98 Dorsalgia, unspecified (Sacral and sacrococcygeal region)	0.698	0.302
M54.97 Dorsalgia, unspecified (Lumbosacral region)	0.698	0.302
M54.95 Dorsalgia, unspecified (Thoracolumbar region)	0.698	0.302
M54.94 Dorsalgia, unspecified (Thoracic region)	0.698	0.302
M54.93 Dorsalgia, unspecified (Cervicothoracic region)	0.698	0.302
M54.92 Dorsalgia, unspecified (Cervical region)	0.698	0.302
M54.91 Dorsalgia, unspecified (Occipito-atlanto-axial region)	0.698	0.302
M54.90 Dorsalgia, unspecified (Multiple sites in spine)	0.698	0.302
M23.8 Other internal derangements of knee	0.698	0.302
M84 Disorders of continuity of bone	0.698	0.302
M54.2 Cervicalgia	0.693	0.306
S20-S29 Injuries to the thorax	0.693	0.307
M45-M49 Spondylopathies	0.692	0.308
S09.9 Unspecified injury of head	0.691	0.309
Z09.0 Follow-up examination after surgery for other conditions	0.690	0.310
M54.4 Lumbago with sciatica	0.688	0.312
M54.57 Low back pain (Lumbosacral region)	0.687	0.313
Chapter I Certain infectious and parasitic diseases	0.684	0.316
T15-T19 Effects of foreign body entering through natural orifice	0.682	0.318
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.682	0.318
M54.12 Radiculopathy (Cervical region)	0.681	0.319
F33 Recurrent depressive disorder	0.680	0.320
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.677	0.323
M25.59 Pain in joint (Site unspecified)	0.676	0.324
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.673	0.327
Z13 Special screening examination for other diseases and disorders	0.672	0.328
F99-F99 Unspecified mental disorder	0.670	0.330
M31.3 Wegener's granulomatosis	0.666	0.334
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis	0.665	0.335
M23.9 Internal derangement of knee, unspecified	0.664	0.336
M23.6 Other spontaneous disruption of ligament(s) of knee	0.664	0.336
M23.5 Chronic instability of knee	0.664	0.336
M23.1 Discoid meniscus (congenital)	0.664	0.336
M23.0 Cystic meniscus	0.664	0.336
S40 Superficial injury of shoulder and upper arm	0.662	0.338
Chapter XII Diseases of the skin and subcutaneous tissue	0.661	0.339
Z13.0 Special screening examination for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.661	0.339
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.661	0.339
M21.4 Flat foot [pes planus] (acquired)	0.660	0.340
S70 Superficial injury of hip and thigh	0.660	0.340
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.659	0.341
M40-M43 Deforming dorsopathies	0.658	0.342
M25.86 Other specified joint disorders (Lower leg)	0.656	0.344
Q60-Q64 Congenital malformations of the urinary system	0.656	0.344
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.654	0.346
M25.76 Osteophyte (Lower leg)	0.654	0.346
S50-S59 Injuries to the elbow and forearm	0.651	0.349
M21.3 Wrist or foot drop (acquired)	0.649	0.351
M22.8 Other disorders of patella	0.648	0.352
S02 Fracture of skull and facial bones	0.648	0.352
T85 Complications of other internal prosthetic devices, implants and grafts	0.647	0.353
Chapter IX Diseases of the circulatory system	0.647	0.353
Chapter XXII Codes for special purposes	0.646	0.354
M23.4 Loose body in knee	0.645	0.355
T66-T78 Other and unspecified effects of external causes	0.644	0.356
T33-T35 Frostbite	0.641	0.359
T26-T28 Burns and corrosions confined to eye and internal organs	0.641	0.359
T20-T25 Burns and corrosions of external body surface, specified by site	0.641	0.359
T00-T07 Injuries involving multiple body regions	0.641	0.359
S10-S19 Injuries to the neck	0.641	0.359
M25.58 Pain in joint (Other)	0.641	0.359
M25.52 Pain in joint (Upper arm)	0.641	0.359
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.640	0.360
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.638	0.362
M23.3 Other meniscus derangements	0.634	0.366
M25.75 Osteophyte (Pelvic region and thigh)	0.633	0.367
F30 Manic episode	0.632	0.368
M51 Other intervertebral disk disorders	0.632	0.368
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.631	0.369
B95-B98 Bacterial, viral and other infectious agents	0.631	0.369
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.631	0.369
M25.77 Osteophyte (Ankle and foot)	0.628	0.372
M23.29 Derangement of meniscus due to old tear or injury (Unspecified ligament or Unspecified meniscus)	0.628	0.372
M23.27 Derangement of meniscus due to old tear or injury-Capsular	0.628	0.372
M20.0 Deformity of finger(s)	0.628	0.372
T87 Complications peculiar to reattachment and amputation	0.628	0.372
T86 Failure and rejection of transplanted organs and tissues	0.628	0.372
T80 Complications following infusion, transfusion and therapeutic injection	0.628	0.372
M50 Cervical disk disorders	0.627	0.373
Chapter XVI Certain conditions originating in the perinatal period	0.625	0.375
M25.49 Effusion of joint (Site unspecified)	0.624	0.376
M25.48 Effusion of joint (Other)	0.624	0.376
M25.47 Effusion of joint (Ankle and foot)	0.624	0.376
M25.45 Effusion of joint (Pelvic region and thigh)	0.624	0.376
M25.44 Effusion of joint (Hand)	0.624	0.376
M25.43 Effusion of joint (Forearm)	0.624	0.376
M25.42 Effusion of joint (Upper arm)	0.624	0.376
M25.41 Effusion of joint (Shoulder region)	0.624	0.376
M25.40 Effusion of joint (Multiple sites)	0.624	0.376
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.624	0.376
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.624	0.376
T84.3 Mechanical complication of other bone devices, implants and grafts	0.624	0.376
M81 Osteoporosis without pathological fracture	0.623	0.376
M24.5 Contracture of joint	0.623	0.377
S00 Superficial injury of head	0.622	0.378
Z29 Need for other prophylactic measures	0.621	0.378
M23.25 Derangement of meniscus due to old tear or injury (Posterior horn of lateral meniscus)	0.620	0.380
S82.8 Fractures of other parts of lower leg	0.619	0.381
I84 Haemorrhoids	0.616	0.384
M54.19 Radiculopathy (Site unspecified)	0.615	0.385
M54.18 Radiculopathy (Sacral and sacrococcygeal region)	0.615	0.385
M54.15 Radiculopathy (Thoracolumbar region)	0.615	0.385
M54.14 Radiculopathy (Thoracic region)	0.615	0.385
M54.13 Radiculopathy (Cervicothoracic region)	0.615	0.385
M54.11 Radiculopathy (Occipito-atlanto-axial region)	0.615	0.385
M54.10 Radiculopathy (Multiple sites in spine)	0.615	0.385
S06 Intracranial injury	0.615	0.385
S61 Open wound of wrist and hand	0.613	0.387
M21.1 Varus deformity, not elsewhere classified	0.612	0.387
T84.2 Mechanical complication of internal fixation device of other bones	0.610	0.389
Q38-Q45 Other congenital malformations of the digestive system	0.610	0.390
M84.1 Nonunion of fracture [pseudarthrosis]	0.609	0.391
M54.16 Radiculopathy (Lumbar region)	0.609	0.391
F31 Bipolar affective disorder	0.607	0.393
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.606	0.393
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.606	0.394
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.604	0.396
F70-F79 Mental retardation	0.604	0.396
F60-F69 Disorders of adult personality and behaviour	0.604	0.396
F80-F89 Disorders of psychological development	0.604	0.396
I05-I09 Chronic rheumatic heart diseases	0.603	0.397
T88 Other complications of surgical and medical care, not elsewhere classified	0.602	0.398
F32.9 Depressive episode, unspecified	0.601	0.399
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.597	0.403
M31.6 Other giant cell arteritis	0.596	0.404
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.595	0.405
M21.9 Acquired deformity of limb, unspecified	0.595	0.405
M21.8 Other specified acquired deformities of limbs	0.595	0.405
M21.7 Unequal limb length (acquired)	0.595	0.405
M21.6 Other acquired deformities of ankle and foot	0.595	0.405
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.595	0.405
M21.2 Flexion deformity	0.595	0.405
M21.0 Valgus deformity, not elsewhere classified	0.595	0.405
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.593	0.406
S08 Traumatic amputation of part of head	0.593	0.407
S07 Crushing injury of head	0.593	0.407
S05 Injury of eye and orbit	0.593	0.407
S04 Injury of cranial nerves	0.593	0.407
S03 Dislocation, sprain and strain of joints and ligaments of head	0.593	0.407
D69 Purpura and other haemorrhagic conditions	0.591	0.409
S01 Open wound of head	0.591	0.409
S70.9 Superficial injury of hip and thigh, unspecified	0.590	0.410
Z08 Follow-up examination after treatment for malignant neoplasm	0.590	0.410
M25.51 Pain in joint (Shoulder region)	0.589	0.411
M85 Other disorders of bone density and structure	0.588	0.411
M83 Adult osteomalacia	0.588	0.411
M82 Osteoporosis in diseases classified elsewhere	0.588	0.411
I84.9 Unspecified haemorrhoids without complication	0.586	0.414
M25.79 Osteophyte (Site unspecified)	0.585	0.415
M25.73 Osteophyte (Forearm)	0.585	0.415
M25.72 Osteophyte (Upper arm)	0.585	0.415
M25.71 Osteophyte (Shoulder region)	0.585	0.415
M25.70 Osteophyte (Multiple sites)	0.585	0.415
M65-M68 Disorders of synovium and tendon	0.584	0.415
S90-S99 Injuries to the ankle and foot	0.583	0.417
T31 Burns classified according to extent of body surface involved	0.582	0.418
S89 Other and unspecified injuries of lower leg	0.582	0.418
S88 Traumatic amputation of lower leg	0.582	0.418
S87 Crushing injury of lower leg	0.582	0.418
S86 Injury of muscle and tendon at lower leg level	0.582	0.418
S85 Injury of blood vessels at lower leg level	0.582	0.418
S84 Injury of nerves at lower leg level	0.582	0.418
M31.9 Necrotising vasculopathy, unspecified	0.581	0.419
M31.8 Other specified necrotising vasculopathies	0.581	0.419
M31.7 Microscopic polyangiitis	0.581	0.419
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.581	0.419
M31.4 Aortic arch syndrome [Takayasu]	0.581	0.419
M31.2 Lethal midline granuloma	0.581	0.419
M31.1 Thrombotic microangiopathy	0.581	0.419
M31.0 Hypersensitivity angiitis	0.581	0.419
M05-M14 Inflammatory polyarthropathies	0.581	0.419
M25.53 Pain in joint (Forearm)	0.580	0.420
M95 Other acquired deformities of musculoskeletal system and connective tissue	0.580	0.420
M25.74 Osteophyte (Hand)	0.579	0.421
S49 Other and unspecified injuries of shoulder and upper arm	0.578	0.422
S48 Traumatic amputation of shoulder and upper arm	0.578	0.422
S46 Injury of muscle and tendon at shoulder and upper arm level	0.578	0.422
S45 Injury of blood vessels at shoulder and upper arm level	0.578	0.422
S44 Injury of nerves at shoulder and upper arm level	0.578	0.422
S41 Open wound of shoulder and upper arm	0.578	0.422
S47 Crushing injury of shoulder and upper arm	0.578	0.422
F10.4 Withdrawal state with delirium	0.578	0.422
S80.9 Superficial injury of lower leg, unspecified	0.578	0.422
Z01.6 Radiological examination, not elsewhere classified	0.574	0.426
S81 Open wound of lower leg	0.574	0.426
B35-B49 Mycoses	0.574	0.426
S42.0 Fracture of clavicle	0.574	0.426
F38 Other mood [affective] disorders	0.573	0.427
F34 Persistent mood [affective] disorders	0.573	0.427
F39 Unspecified mood [affective] disorder	0.573	0.427
S80.1 Contusion of other and unspecified parts of lower leg	0.572	0.428
S61.0 Open wound of finger(s) without damage to nail	0.570	0.430
F10.3 Withdrawal state	0.570	0.430
M25.89 Other specified joint disorders (Site unspecified)	0.568	0.432
M25.88 Other specified joint disorders (Other)	0.568	0.432
M25.87 Other specified joint disorders (Ankle and foot)	0.568	0.432
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.568	0.432
M25.84 Other specified joint disorders (Hand)	0.568	0.432
M25.83 Other specified joint disorders (Forearm)	0.568	0.432
M25.82 Other specified joint disorders (Upper arm)	0.568	0.432
M25.81 Other specified joint disorders (Shoulder region)	0.568	0.432
M25.80 Other specified joint disorders (Multiple sites)	0.568	0.432
Z29.2 Other prophylactic chemotherapy	0.568	0.432
M22.1 Recurrent subluxation of patella	0.567	0.433
M22.9 Disorder of patella, unspecified	0.567	0.433
M22.3 Other derangements of patella	0.567	0.433
M22.2 Patellofemoral disorders	0.567	0.433
M22.0 Recurrent dislocation of patella	0.567	0.433
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.567	0.433
L60-L75 Disorders of skin appendages	0.567	0.433
M23.21 Derangement of meniscus due to old tear or injury (Anterior cruciate ligament or Anterior horn of medial meniscus)	0.566	0.433
S42.4 Fracture of lower end of humerus	0.566	0.434
M25.50 Pain in joint (Multiple sites)	0.565	0.434
S82.0 Fracture of patella	0.565	0.435
S20 Superficial injury of thorax	0.565	0.435
S82.5 Fracture of medial malleolus	0.565	0.435
I08 Multiple valve diseases	0.564	0.436
Q61 Cystic kidney disease	0.563	0.436
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.562	0.438
T79 Certain early complications of trauma, not elsewhere classified	0.560	0.440
M23.89 Other internal derangements of knee (Unspecified ligament or Unspecified meniscus)	0.559	0.441
Q00-Q07 Congenital malformations of the nervous system	0.559	0.441
M25.78 Osteophyte (Other)	0.559	0.441
S60 Superficial injury of wrist and hand	0.559	0.441
M22.4 Chondromalacia patellae	0.558	0.442
F00-F09 Organic, including symptomatic, mental disorders	0.557	0.443
M89 Other disorders of bone	0.557	0.443
M34.9 Systemic sclerosis, unspecified	0.556	0.444
M23.24 Derangement of meniscus due to old tear or injury (Lateral collateral ligament or Anterior horn of lateral meniscus)	0.555	0.445
Z04 Examination and observation for other reasons	0.555	0.445
Z11 Special screening examination for infectious and parasitic diseases	0.554	0.446
F19 Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances	0.552	0.447
F18 Mental and behavioural disorders due to use of volatile solvents	0.552	0.447
F16 Mental and behavioural disorders due to use of hallucinogens	0.552	0.447
F15 Mental and behavioural disorders due to use of other stimulants, including caffeine	0.552	0.447
F14 Mental and behavioural disorders due to use of cocaine	0.552	0.447
F13 Mental and behavioural disorders due to use of sedatives or hypnotics	0.552	0.447
F12 Mental and behavioural disorders due to use of cannabinoids	0.552	0.447
F11 Mental and behavioural disorders due to use of opioids	0.552	0.447
M24.9 Joint derangement, unspecified	0.552	0.448
M24.8 Other specific joint derangements, not elsewhere classified	0.552	0.448
M24.7 Protrusio acetabuli	0.552	0.448
M24.6 Ankylosis of joint	0.552	0.448
M24.4 Recurrent dislocation and subluxation of joint	0.552	0.448
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.552	0.448
M24.2 Disorder of ligament	0.552	0.448
M24.0 Loose body in joint	0.552	0.448
I87 Other disorders of veins	0.552	0.448
S82.3 Fracture of lower end of tibia	0.552	0.448
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.550	0.450
Q80-Q89 Other congenital malformations	0.550	0.450
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.550	0.450
Q35-Q37 Cleft lip and cleft palate	0.550	0.450
Q30-Q34 Congenital malformations of the respiratory system	0.550	0.450
S80.0 Contusion of knee	0.550	0.450
F32.3 Severe depressive episode with psychotic symptoms	0.548	0.452
Q50-Q56 Congenital malformations of genital organs	0.548	0.452
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.547	0.453
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.547	0.453
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.547	0.453
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.547	0.453
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.547	0.453
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.547	0.453
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.547	0.453
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.547	0.453
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.547	0.453
F99 Mental disorder, not otherwise specified	0.547	0.453
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified	0.547	0.453
S30 Superficial injury of abdomen, lower back and pelvis	0.546	0.454
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.544	0.456
S79 Other and unspecified injuries of hip and thigh	0.543	0.457
S78 Traumatic amputation of hip and thigh	0.543	0.457
S77 Crushing injury of hip and thigh	0.543	0.457
S76 Injury of muscle and tendon at hip and thigh level	0.543	0.457
S75 Injury of blood vessels at hip and thigh level	0.543	0.457
S74 Injury of nerves at hip and thigh level	0.543	0.457
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.543	0.457
S71 Open wound of hip and thigh	0.543	0.457
F33.9 Recurrent depressive disorder, unspecified	0.542	0.458
B98 Other specified infectious agents as the cause of diseases classified to other chapters	0.542	0.458
S82.80 Fractures of other parts of lower leg (closed)	0.542	0.458
M99 Biomechanical lesions, not elsewhere classified	0.541	0.459
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.541	0.459
M35 Other systemic involvement of connective tissue	0.540	0.460
S72 Fracture of femur	0.540	0.460
M80 Osteoporosis with pathological fracture	0.539	0.460
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.538	0.462
D69.6 Thrombocytopenia, unspecified	0.538	0.462
Z10 Routine general health check-up of defined subpopulation	0.537	0.462
F10.9 Unspecified mental and behavioural disorder	0.537	0.463
F10.8 Other mental and behavioural disorders	0.537	0.463
F10.7 Residual and late-onset psychotic disorder	0.537	0.463
F10.6 Amnesic syndrome	0.537	0.463
F10.5 Psychotic disorder	0.537	0.463
Z00 General examination and investigation of persons without complaint or reported diagnosis	0.536	0.463
D80-D89 Certain disorders involving the immune mechanism	0.536	0.464
S09.8 Other specified injuries of head	0.536	0.464
S09.7 Multiple injuries of head	0.536	0.464
S09.2 Traumatic rupture of ear drum	0.536	0.464
S09.1 Injury of muscle and tendon of head	0.536	0.464
S09.0 Injury of blood vessels of head, not elsewhere classified	0.536	0.464
S63.6 Sprain and strain of finger(s)	0.536	0.464
F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms	0.535	0.465
T17 Foreign body in respiratory tract	0.534	0.466
S40.0 Contusion of shoulder and upper arm	0.533	0.466
S82.1 Fracture of upper end of tibia	0.533	0.467
I84.2 Internal haemorrhoids without complication	0.532	0.468
L55-L59 Radiation-related disorders of the skin and subcutaneous tissue	0.532	0.468
Z09.7 Follow-up examination after combined treatment for other conditions	0.531	0.468
Z09.4 Follow-up examination after treatment of fracture	0.531	0.468
Z09.3 Follow-up examination after psychotherapy	0.531	0.468
Z09.1 Follow-up examination after radiotherapy for other conditions	0.531	0.468
M34.8 Other forms of systemic sclerosis	0.531	0.469
M34.2 Systemic sclerosis induced by drugs and chemicals	0.531	0.469
M34.1 CR(E)ST syndrome	0.531	0.469
M34.0 Progressive systemic sclerosis	0.531	0.469
M90 Osteopathies in diseases classified elsewhere	0.531	0.469
M88 Paget's disease of bone [osteitis deformans]	0.531	0.469
M87 Osteonecrosis	0.531	0.469
M86 Osteomyelitis	0.531	0.469
Z01.8 Other specified special examinations	0.531	0.469
M45 Ankylosing spondylitis	0.530	0.470
I08.1 Disorders of both mitral and tricuspid valves	0.530	0.470
S82.4 Fracture of fibula alone	0.529	0.471
F40-F48 Neurotic, stress-related and somatoform disorders	0.528	0.472
M24.1 Other articular cartilage disorders	0.528	0.472
M46 Other inflammatory spondylopathies	0.527	0.473
M53.9 Dorsopathy, unspecified	0.526	0.474
M53.8 Other specified dorsopathies	0.526	0.474
M53.2 Spinal instabilities	0.526	0.474
M53.1 Cervicobrachial syndrome	0.526	0.474
M53.0 Cervicocranial syndrome	0.526	0.474
T94 Sequelae of injuries involving multiple and unspecified body regions	0.526	0.474
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.526	0.474
F32.1 Moderate depressive episode	0.525	0.475
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)	0.524	0.476
S51 Open wound of forearm	0.523	0.477
S42.3 Fracture of shaft of humerus	0.522	0.478
T85.3 Mechanical complication of other ocular prosthetic devices, imnplants and grafts	0.522	0.478
S69 Other and unspecified injuries of wrist and hand	0.522	0.478
S67 Crushing injury of wrist and hand	0.522	0.478
S65 Injury of blood vessels at wrist and hand level	0.522	0.478
F33.1 Recurrent depressive disorder, current episode moderate	0.521	0.478
S82.9 Fracture of lower leg, part unspecified	0.521	0.479
S82.7 Multiple fractures of lower leg	0.521	0.479
L20-L30 Dermatitis and eczema	0.520	0.480
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.519	0.481
M23.32 Other meniscus derangements (Posterior cruciate ligament or Posterior horn of medial meniscus)	0.518	0.482
M24.54 Contracture of joint (Hand)	0.517	0.483
S82.2 Fracture of shaft of tibia	0.515	0.485
M30.8 Other conditions related to polyarteritis nodosa	0.514	0.486
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.514	0.486
M30.2 Juvenile polyarteritis	0.514	0.486
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.514	0.486
M30.0 Polyarteritis nodosa	0.514	0.486
M32.9 Systemic lupus erythematosus, unspecified	0.514	0.486
M32.8 Other forms of systemic lupus erythematosus	0.514	0.486
M32.1 Systemic lupus erythematosus with organ or system involvement	0.514	0.486
M32.0 Drug-induced systemic lupus erythematosus	0.514	0.486
M33.9 Dermatopolymyositis, unspecified	0.514	0.486
M33.2 Polymyositis	0.514	0.486
M33.1 Other dermatomyositis	0.514	0.486
M33.0 Juvenile dermatomyositis	0.514	0.486
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.514	0.486
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.514	0.486
M36.3 Arthropathy in other blood disorders	0.514	0.486
M36.2 Haemophilic arthropathy	0.514	0.486
M36.1 Arthropathy in neoplastic disease	0.514	0.486
M36.0 Dermato(poly)myositis in neoplastic disease	0.514	0.486
S66 Injury of muscle and tendon at wrist and hand level	0.514	0.486
M54.09 Panniculitis affecting regions of neck and back (Site unspecified)	0.513	0.486
M54.08 Panniculitis affecting regions of neck and back (Sacral and sacrococcygeal region)	0.513	0.486
M54.07 Panniculitis affecting regions of neck and back (Lumbosacral region)	0.513	0.486
M54.06 Panniculitis affecting regions of neck and back (Lumbar region)	0.513	0.486
M54.05 Panniculitis affecting regions of neck and back (Thoracolumbar region)	0.513	0.486
M54.04 Panniculitis affecting regions of neck and back (Thoracic region)	0.513	0.486
M54.03 Panniculitis affecting regions of neck and back (Cervicothoracic region)	0.513	0.486
M54.02 Panniculitis affecting regions of neck and back (Cervical region)	0.513	0.486
M54.01 Panniculitis affecting regions of neck and back (Occipito-atlanto-axial region)	0.513	0.486
M54.00 Panniculitis affecting regions of neck and back (Multiple sites in spine)	0.513	0.486
M54.69 Pain in thoracic spine-Site unspe	0.513	0.486
M54.68 Pain in thoracic spine-Sacral/sacrococ	0.513	0.486
M54.67 Pain in thoracic spine-Lumbosacral	0.513	0.486
M54.66 Pain in thoracic spine-Lumbar	0.513	0.486
M54.65 Pain in thoracic spine (Thoracolumbar region)	0.513	0.486
M54.64 Pain in thoracic spine (Thoracic region)	0.513	0.486
M54.63 Pain in thoracic spine (Cervicothoracic region)	0.513	0.486
M54.62 Pain in thoracic spine-Cervical	0.513	0.486
M54.61 Pain in thoracic spine-Occipit-atl-axl	0.513	0.486
M54.60 Pain in thoracic spine (Multiple sites in spine)	0.513	0.486

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations