TreeWAS – Variant ID: rs2015648

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E83.1 Disorders of iron metabolism	0.000	0.000	1.000
K90.0 Coeliac disease	0.000	0.000	1.000
E10 Insulin-dependent diabetes mellitus	0.000	0.466	0.534
E10.9 Without complications	0.000	0.468	0.532
E10.4 With neurological complications	0.000	0.502	0.498
E10.5 With peripheral circulatory complications	0.000	0.509	0.491
E10.6 With other specified complications	0.000	0.518	0.481
E10.8 With unspecified complications	0.000	0.550	0.450
E10-E14 Diabetes mellitus	0.000	0.588	0.412
E10.1 With ketoacidosis	0.000	0.601	0.399
E10.2 With renal complications	0.000	0.602	0.398
E10.7 With multiple complications	0.000	0.617	0.383
E10.0 With coma	0.000	0.638	0.362
E13 Other specified diabetes mellitus	0.000	0.651	0.349
E10.3 With ophthalmic complications	0.000	0.653	0.347
E83 Disorders of mineral metabolism	0.000	0.654	0.346
E14 Unspecified diabetes mellitus	0.000	0.684	0.316
K90 Intestinal malabsorption	0.000	0.688	0.312
Chapter IV Endocrine, nutritional and metabolic diseases	0.000	0.690	0.310
E70-E90 Metabolic disorders	0.000	0.694	0.306
E13.9 Without complications	0.000	0.694	0.306
E14.3 With ophthalmic complications	0.000	0.698	0.302
E12 Malnutrition-related diabetes mellitus	0.000	0.704	0.296
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.000	0.731	0.268
E88 Other metabolic disorders	0.000	0.743	0.257
E40-E46 Malnutrition	0.000	0.743	0.257
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.000	0.744	0.256
E13.8 With unspecified complications	0.000	0.750	0.250
E13.7 With multiple complications	0.000	0.750	0.250
E13.6 With other specified complications	0.000	0.750	0.250
E13.5 With peripheral circulatory complications	0.000	0.750	0.250
E13.4 With neurological complications	0.000	0.750	0.250
E13.2 With renal complications	0.000	0.750	0.250
E13.1 With ketoacidosis	0.000	0.750	0.250
E13.0 With coma	0.000	0.750	0.250
E83.9 Disorder of mineral metabolism, unspecified	0.000	0.751	0.248
E83.8 Other disorders of mineral metabolism	0.000	0.751	0.248
E83.2 Disorders of zinc metabolism	0.000	0.751	0.248
E83.0 Disorders of copper metabolism	0.000	0.751	0.248
E85 Amyloidosis	0.000	0.753	0.247
E13.3 With ophthalmic complications	0.000	0.756	0.244
E16 Other disorders of pancreatic internal secretion	0.000	0.761	0.239
E14.5 With peripheral circulatory complications	0.000	0.764	0.236
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.000	0.771	0.229
E14.7 With multiple complications	0.000	0.773	0.226
E14.6 With other specified complications	0.000	0.773	0.226
E14.2 Withrenal complications	0.000	0.773	0.226
E14.0 With coma	0.000	0.773	0.226
E80 Disorders of porphyrin and bilirubin metabolism	0.000	0.774	0.226
E16.2 Hypoglycaemia, unspecified	0.000	0.775	0.225
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.000	0.776	0.224
K90.3 Pancreatic steatorrhoea	0.000	0.776	0.223
K90.2 Blind loop syndrome, not elsewhere classified	0.000	0.776	0.223
K90.1 Tropical sprue	0.000	0.776	0.223
E84 Cystic fibrosis	0.000	0.780	0.219
E77 Disorders of glycoprotein metabolism	0.000	0.780	0.219
E76 Disorders of glycosaminoglycan metabolism	0.000	0.780	0.219
E72 Other disorders of amino-acid metabolism	0.000	0.780	0.219
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.000	0.780	0.219
E70 Disorders of aromatic amino-acid metabolism	0.000	0.780	0.219
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.000	0.780	0.219
E46 Unspecified protein-energy malnutrition	0.000	0.781	0.219
E14.4 With neurological complications	0.000	0.781	0.218
K90.8 Other intestinal malabsorption	0.000	0.785	0.215
E12.9 Without complications	0.000	0.788	0.212
E12.8 With unspecified complications	0.000	0.788	0.212
E12.7 With multiple complications	0.000	0.788	0.212
E12.6 With other specified complications	0.000	0.788	0.212
E12.5 With peripheral circulatory complications	0.000	0.788	0.212
E12.4 With neurological complications	0.000	0.788	0.212
E12.3 With ophthalmic complications	0.000	0.788	0.212
E12.2 With renal complications	0.000	0.788	0.212
E12.1 With ketoacidosis	0.000	0.788	0.212
E12.0 With coma	0.000	0.788	0.212
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.000	0.791	0.209
E65-E68 Obesity and other hyperalimentation	0.000	0.791	0.209
E85.9 Amyloidosis, unspecified	0.000	0.794	0.206
E79 Disorders of purine and pyrimidine metabolism	0.000	0.804	0.196
E88.1 Lipodystrophy, not elsewhere classified	0.000	0.804	0.196
E88.8 Other specified metabolic disorders	0.000	0.805	0.195
E11 Non-insulin-dependent diabetes mellitus	0.000	0.805	0.195
E88.2 Lipomatosis, not elsewhere classified	0.000	0.806	0.194
E15 Nondiabetic hypoglycaemic coma	0.000	0.807	0.193
E14.1 With ketoacidosis	0.000	0.808	0.192
E14.8 With unspecified complications	0.000	0.813	0.187
E85.4 Organ-limited amyloidosis	0.000	0.814	0.186
E88.3 Tumour lysis syndrome	0.000	0.815	0.185
E44 Protein-energy malnutrition of moderate and mild degree	0.000	0.816	0.184
E45 Retarded development following protein-energy malnutrition	0.000	0.816	0.184
E43 Unspecified severe protein-energy malnutrition	0.000	0.816	0.184
E42 Marasmic kwashiorkor	0.000	0.816	0.184
E41 Nutritional marasmus	0.000	0.816	0.184
E40 Kwashiorkor	0.000	0.816	0.184
E89.2 Postprocedural hypoparathyroidism	0.000	0.816	0.184
E80.4 Gilbert's syndrome	0.000	0.821	0.179
E65 Localised adiposity	0.000	0.822	0.178
E85.8 Other amyloidosis	0.000	0.823	0.177
E85.2 Heredofamilial amyloidosis, unspecified	0.000	0.823	0.177
E85.1 Neuropathic heredofamilial amyloidosis	0.000	0.823	0.177
E85.0 Nonneuropathic heredofamilial amyloidosis	0.000	0.823	0.177
E16.0 Drug-induced hypoglycaemia without coma	0.000	0.823	0.177
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.000	0.823	0.177
E89.0 Postprocedural hypothyroidism	0.000	0.827	0.173
E74 Other disorders of carbohydrate metabolism	0.000	0.827	0.173
E88.9 Metabolic disorder, unspecified	0.000	0.828	0.172
E16.9 Disorder of pancreatic internal secretion, unspecified	0.000	0.828	0.172
E16.8 Other specified disorders of pancreatic internal secretion	0.000	0.828	0.172
E16.4 Abnormal secretion of gastrin	0.000	0.828	0.172
E16.3 Increased secretion of glucagon	0.000	0.828	0.172
E89.4 Postprocedural ovarian failure	0.000	0.829	0.171
E11.5 With peripheral circulatory complications	0.000	0.834	0.166
E75.5 Other lipid storage disorders	0.000	0.835	0.165
E85.3 Secondary systemic amyloidosis	0.000	0.835	0.165
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.000	0.836	0.164
E89.8 Other postprocedural endocrine and metabolic disorders	0.000	0.836	0.164
E89.5 Postprocedural testicular hypofunction	0.000	0.836	0.164
E89.1 Postprocedural hypoinsulinaemia	0.000	0.836	0.164
E80.7 Disorder of bilirubin metabolism, unspecified	0.000	0.838	0.162
E80.5 Crigler-Najjar syndrome	0.000	0.838	0.162
E80.3 Defects of catalase and peroxydase	0.000	0.838	0.162
E80.1 Porphyria cutanea tarda	0.000	0.838	0.162
E80.0 Hereditary erythropoietic porphyria	0.000	0.838	0.162
E73 Lactose intolerance	0.000	0.839	0.161
E75.6 Lipid storage disorder, unspecified	0.000	0.839	0.161
E75.4 Neuronal ceroid lipofuscinosis	0.000	0.839	0.161
E75.3 Sphingolipidosis, unspecified	0.000	0.839	0.161
E75.2 Other sphingolipidosis	0.000	0.839	0.161
E75.1 Other gangliosidosis	0.000	0.839	0.161
E75.0 GM2 gangliosidosis	0.000	0.839	0.161
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.000	0.842	0.157
E70.8 Other disorders of aromatic amino-acid metabolism	0.000	0.842	0.157
E70.3 Albinism	0.000	0.842	0.157
E70.2 Disorders of tyrosine metabolism	0.000	0.842	0.157
E70.1 Other hyperphenylalaninaemias	0.000	0.842	0.157
E70.0 Classical phenylketonuria	0.000	0.842	0.157
E71.3 Disorders of fatty-acid metabolism	0.000	0.842	0.157
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.000	0.842	0.157
E71.1 Other disorders of branched-chain amino-acid metabolism	0.000	0.842	0.157
E71.0 Maple-syrup-urine disease	0.000	0.842	0.157
E72.9 Disorder of amino-acid metabolism, unspecified	0.000	0.842	0.157
E72.8 Other specified disorders of amino-acid metabolism	0.000	0.842	0.157
E72.5 Disorders of glycine metabolism	0.000	0.842	0.157
E72.4 Disorders of ornithine metabolism	0.000	0.842	0.157
E72.3 Disorders of lysine and hydroxylysine metabolism	0.000	0.842	0.157
E72.2 Disorders of urea cycle metabolism	0.000	0.842	0.157
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.000	0.842	0.157
E72.0 Disorders of amino-acid transport	0.000	0.842	0.157
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.000	0.842	0.157
E76.8 Other disorders of glucosaminoglycan metabolism	0.000	0.842	0.157
E76.3 Mucopolysaccharidosis, unspecified	0.000	0.842	0.157
E76.2 Other mucopolysaccharidoses	0.000	0.842	0.157
E76.1 Mucopolysaccharidosis, type II	0.000	0.842	0.157
E76.0 Mucopolysaccharidosis, type I	0.000	0.842	0.157
E77.9 Disorder of glycoprotein metabolism, unspecified	0.000	0.842	0.157
E77.8 Other disorders of glycoprotein metabolism	0.000	0.842	0.157
E77.1 Defects in glycoprotein degradation	0.000	0.842	0.157
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.000	0.842	0.157
E84.9 Cystic fibrosis, unspecified	0.000	0.842	0.157
E84.8 Cystic fibrosis with other manifestations	0.000	0.842	0.157
E84.1 Cystic fibrosis with intestinal manifestations	0.000	0.842	0.157
E84.0 Cystic fibrosis with pulmonary manifestations	0.000	0.842	0.157
E80.2 Other porphyria	0.000	0.844	0.156
E80.6 Other disorders of bilirubin metabolism	0.000	0.846	0.154
E67 Other hyperalimentation	0.000	0.850	0.150
E68 Sequelae of hyperalimentation	0.000	0.850	0.150
E11.0 With coma	0.000	0.851	0.149
E00-E07 Disorders of thyroid gland	0.000	0.854	0.146
E11.8 With unspecified complications	0.000	0.854	0.146
E83.3 Disorders of phosphorus metabolism	0.000	0.855	0.144
E11.1 With ketoacidosis	0.000	0.857	0.143
E83.4 Disorders of magnesium metabolism	0.000	0.858	0.142
E11.2 With renal complications	0.000	0.859	0.141
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.000	0.859	0.141
E79.8 Other disorders of purine and pyrimidine metabolism	0.000	0.859	0.141
E79.1 Lesch-Nyhan syndrome	0.000	0.859	0.141
E11.7 With multiple complications	0.000	0.860	0.140
E11.6 With other specified complications	0.000	0.866	0.134
E44.1 Mild protein-energy malnutrition	0.000	0.868	0.132
E44.0 Moderate protein-energy malnutrition	0.000	0.868	0.132
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.000	0.868	0.132
E16.1 Other hypoglycaemia	0.000	0.870	0.130
E11.4 With neurological complications	0.000	0.872	0.128
E78.9 Disorder of lipoprotein metabolism, unspecified	0.000	0.873	0.127
E74.9 Disorder of carbohydrate metabolism, unspecified	0.000	0.875	0.124
E74.8 Other specified disorders of carbohydrate metabolism	0.000	0.875	0.124
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.000	0.875	0.124
E74.2 Disorders of galactose metabolism	0.000	0.875	0.124
E74.1 Disorders of fructose metabolism	0.000	0.875	0.124
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.000	0.882	0.117
E73.8 Other lactose intolerance	0.000	0.884	0.115
E73.1 Secondary lactase deficiency	0.000	0.884	0.115
E73.0 Congenital lactase deficiency	0.000	0.884	0.115
E74.0 Glycogen storage disease	0.000	0.886	0.114
E07 Other disorders of thyroid	0.000	0.886	0.114
E04 Other non-toxic goitre	0.000	0.887	0.113
E87 Other disorders of fluid, electrolyte and acid-base balance	0.000	0.891	0.109
E67.8 Other specified hyperalimentation	0.000	0.892	0.107
E67.3 Hypervitaminosis D	0.000	0.892	0.107
E67.2 Megavitamin-B6 syndrome	0.000	0.892	0.107
E67.1 Hypercarotenaemia	0.000	0.892	0.107
E67.0 Hypervitaminosis A	0.000	0.892	0.107
E78.4 Other hyperlipidaemia	0.000	0.893	0.107
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.895	0.105
E00 Congenital iodine-deficiency syndrome	0.000	0.895	0.105
E50-E64 Other nutritional deficiencies	0.000	0.896	0.104
E11.3 With ophthalmic complications	0.000	0.896	0.104
E04.9 Non-toxic goitre, unspecified	0.000	0.900	0.100
E78.6 Lipoprotein deficiency	0.000	0.900	0.100
E89.3 Postprocedural hypopituitarism	0.000	0.901	0.099
E87.3 Alkalosis	0.000	0.901	0.099
E06 Thyroiditis	0.000	0.901	0.099
K90.9 Intestinal malabsorption, unspecified	0.001	0.904	0.096
E07.9 Disorder of thyroid, unspecified	0.000	0.904	0.096
E03 Other hypothyroidism	0.000	0.905	0.095
E78.3 Hyperchylomicronaemia	0.000	0.905	0.095
E74.3 Other disorders of intestinal carbohydrate absorption	0.000	0.905	0.094
E14.9 Without complications	0.000	0.905	0.095
E20-E35 Disorders of other endocrine glands	0.000	0.910	0.090
E87.0 Hyperosmolality and hypernatraemia	0.000	0.910	0.090
E78.1 Pure hyperglyceridaemia	0.000	0.910	0.090
E78.2 Mixed hyperlipidaemia	0.000	0.913	0.087
E03.8 Other specified hypothyroidism	0.000	0.914	0.086
E04.0 Non-toxic diffuse goitre	0.000	0.914	0.086
E83.5 Disorders of calcium metabolism	0.000	0.916	0.084
E87.2 Acidosis	0.000	0.918	0.082
E07.1 Dyshormogenetic goitre	0.000	0.918	0.082
E07.0 Hypersecretion of calcitonin	0.000	0.918	0.082
E04.8 Other specified non-toxic goitre	0.000	0.919	0.081
E02 Subclinical iodine-deficiency hypothyroidism	0.000	0.920	0.080
E87.7 Fluid overload	0.000	0.920	0.080
E87.4 Mixed disorder of acid-base balance	0.000	0.922	0.078
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.000	0.924	0.075
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.000	0.924	0.075
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.000	0.924	0.075
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.000	0.924	0.075
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.000	0.924	0.075
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.000	0.924	0.075
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.000	0.924	0.075
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.000	0.924	0.075
E04.2 Non-toxic multinodular goitre	0.000	0.925	0.075
E64 Sequelae of malnutrition and other nutritional deficiencies	0.000	0.925	0.075
E63 Other nutritional deficiencies	0.000	0.925	0.075
E56 Other vitamin deficiencies	0.000	0.925	0.075
E50 Vitamin A deficiency	0.000	0.925	0.075
E60 Dietary zinc deficiency	0.000	0.925	0.075
E59 Dietary selenium deficiency	0.000	0.925	0.075
E54 Ascorbic acid deficiency	0.000	0.925	0.075
E52 Niacin deficiency [pellagra]	0.000	0.925	0.075
E58 Dietary calcium deficiency	0.000	0.926	0.074
E06.3 Autoimmune thyroiditis	0.000	0.927	0.073
E07.8 Other specified disorders of thyroid	0.000	0.928	0.072
E06.5 Other chronic thyroiditis	0.000	0.929	0.071
E06.4 Drug-induced thyroiditis	0.000	0.929	0.071
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.000	0.929	0.071
E06.1 Subacute thyroiditis	0.000	0.929	0.071
E06.0 Acute thyroiditis	0.000	0.929	0.071
E66 Obesity	0.000	0.930	0.070
E51 Thiamine deficiency	0.000	0.931	0.069
E53 Deficiency of other B group vitamins	0.000	0.931	0.069
E03.5 Myxoedema coma	0.000	0.931	0.068
E03.4 Atrophy of thyroid (acquired)	0.000	0.931	0.068
E03.3 Postinfectious hypothyroidism	0.000	0.931	0.068
E03.1 Congenital hypothyroidism without goitre	0.000	0.931	0.068
E03.0 Congenital hypothyroidism with diffuse goitre	0.000	0.931	0.068
E20 Hypoparathyroidism	0.000	0.931	0.068
E28 Ovarian dysfunction	0.000	0.932	0.068
E26 Hyperaldosteronism	0.000	0.932	0.068
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.000	0.933	0.067
E23 Hypofunction and other disorders of pituitary gland	0.000	0.934	0.066
E29 Testicular dysfunction	0.000	0.935	0.065
E35 Disorders of endocrine glands in diseases classified elsewhere	0.000	0.935	0.065
E32 Diseases of thymus	0.000	0.935	0.065
E31 Polyglandular dysfunction	0.000	0.935	0.065
E30 Disorders of puberty, not elsewhere classified	0.000	0.935	0.065
E25 Adrenogenital disorders	0.000	0.935	0.065
E87.5 Hyperkalaemia	0.000	0.937	0.063
E05 Thyrotoxicosis [hyperthyroidism]	0.000	0.937	0.063
E06.9 Thyroiditis, unspecified	0.000	0.938	0.062
E23.2 Diabetes insipidus	0.000	0.939	0.061
E28.2 Polycystic ovarian syndrome	0.000	0.940	0.060
E34 Other endocrine disorders	0.000	0.940	0.060
E55 Vitamin D deficiency	0.000	0.941	0.059
E24 Cushing's syndrome	0.000	0.941	0.059
E66.2 Extreme obesity with alveolar hypoventilation	0.000	0.941	0.059
E04.1 Non-toxic single thyroid nodule	0.000	0.942	0.058
E73.9 Lactose intolerance, unspecified	0.001	0.942	0.057
E78.8 Other disorders of lipoprotein metabolism	0.000	0.944	0.056
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.000	0.945	0.055
E50.9 Vitamin A deficiency, unspecified	0.000	0.946	0.054
E50.8 Other manifestations of vitamin A deficiency	0.000	0.946	0.054
E50.7 Other ocular manifestations of vitamin A deficiency	0.000	0.946	0.054
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.000	0.946	0.054
E50.5 Vitamin A deficiency with night blindness	0.000	0.946	0.054
E50.4 Vitamin A deficiency with keratomalacia	0.000	0.946	0.054
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.000	0.946	0.054
E50.2 Vitamin A deficiency with corneal xerosis	0.000	0.946	0.054
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.000	0.946	0.054
E50.0 Vitamin A deficiency with conjunctival xerosis	0.000	0.946	0.054
E56.9 Vitamin deficiency, unspecified	0.000	0.946	0.054
E56.8 Deficiency of other vitamins	0.000	0.946	0.054
E56.1 Deficiency of vitamin K	0.000	0.946	0.054
E56.0 Deficiency of vitamin E	0.000	0.946	0.054
E63.9 Nutritional deficiency, unspecified	0.000	0.946	0.054
E63.8 Other specified nutritional deficiencies	0.000	0.946	0.054
E63.1 Imbalance of constituents of food intake	0.000	0.946	0.054
E63.0 Essential fatty acid [EFA] deficiency	0.000	0.946	0.054
E64.9 Sequelae of unspecified nutritional deficiency	0.000	0.946	0.054
E64.8 Sequelae of other nutritional deficiencies	0.000	0.946	0.054
E64.3 Sequelae of rickets	0.000	0.946	0.054
E64.2 Sequelae of vitamin C deficiency	0.000	0.946	0.054
E64.1 Sequelae of vitamin A deficiency	0.000	0.946	0.054
E64.0 Sequelae of protein-energy malnutrition	0.000	0.946	0.054
E27 Other disorders of adrenal gland	0.000	0.946	0.053
E20.9 Hypoparathyroidism, unspecified	0.000	0.947	0.053
E26.0 Primary hyperaldosteronism	0.000	0.948	0.051
E66.1 Drug-induced obesity	0.000	0.949	0.050
E51.9 Thiamine deficiency, unspecified	0.000	0.950	0.050
E51.8 Other manifestations of thiamine deficiency	0.000	0.950	0.050
E51.1 Beriberi	0.000	0.950	0.050
E27.1 Primary adrenocortical insufficiency	0.000	0.950	0.050
E53.1 Pyridoxine deficiency	0.000	0.950	0.050
E53.0 Riboflavin deficiency	0.000	0.950	0.050
E20.8 Other hypoparathyroidism	0.000	0.951	0.049
E20.1 Pseudohypoparathyroidism	0.000	0.951	0.049
E20.0 Idiopathic hypoparathyroidism	0.000	0.951	0.049
E53.9 Vitamin B deficiency, unspecified	0.000	0.951	0.049
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.000	0.951	0.049
E28.9 Ovarian dysfunction, unspecified	0.000	0.951	0.049
E28.8 Other ovarian dysfunction	0.000	0.951	0.049
E28.1 Androgen excess	0.000	0.951	0.049
E28.0 Oestrogen excess	0.000	0.951	0.049
E24.2 Drug-induced Cushing's syndrome	0.000	0.951	0.049
E26.9 Hyperaldosteronism, unspecified	0.000	0.951	0.049
E26.8 Other hyperaldosteronism	0.000	0.951	0.049
E26.1 Secondary hyperaldosteronism	0.000	0.951	0.049
E66.0 Obesity due to excess calories	0.000	0.951	0.048
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.000	0.952	0.047
E23.1 Drug-induced hypopituitarism	0.000	0.952	0.047
E05.8 Other thyrotoxicosis	0.000	0.953	0.047
E29.1 Testicular hypofunction	0.000	0.953	0.047
E29.9 Testicular dysfunction, unspecified	0.000	0.953	0.047
E29.8 Other testicular dysfunction	0.000	0.953	0.047
E29.0 Testicular hyperfunction	0.000	0.953	0.047
E25.9 Adrenogenital disorder, unspecified	0.000	0.953	0.047
E25.8 Other adrenogenital disorders	0.000	0.953	0.047
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.000	0.953	0.047
E30.9 Disorder of puberty, unspecified	0.000	0.953	0.047
E30.8 Other disorders of puberty	0.000	0.953	0.047
E30.1 Precocious puberty	0.000	0.953	0.047
E30.0 Delayed puberty	0.000	0.953	0.047
E31.9 Polyglandular dysfunction, unspecified	0.000	0.953	0.047
E31.8 Other polyglandular dysfunction	0.000	0.953	0.047
E31.1 Polyglandular hyperfunction	0.000	0.953	0.047
E31.0 Autoimmune polyglandular failure	0.000	0.953	0.047
E32.9 Disease of thymus, unspecified	0.000	0.953	0.047
E32.8 Other diseases of thymus	0.000	0.953	0.047
E32.1 Abscess of thymus	0.000	0.953	0.047
E32.0 Persistent hyperplasia of thymus	0.000	0.953	0.047
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.000	0.953	0.047
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.000	0.953	0.047
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.000	0.953	0.047
E23.7 Disorder of pituitary gland, unspecified	0.000	0.954	0.046
E05.5 Thyroid crisis or storm	0.000	0.955	0.045
E05.4 Thyrotoxicosis factitia	0.000	0.955	0.045
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.000	0.955	0.045
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.000	0.955	0.045
E53.8 Deficiency of other specified B group vitamins	0.000	0.956	0.044
E51.2 Wernicke's encephalopathy	0.000	0.956	0.044
E34.9 Endocrine disorder, unspecified	0.000	0.956	0.044
E34.5 Androgen resistance syndrome	0.000	0.957	0.043
E34.4 Constitutional tall stature	0.000	0.957	0.043
E34.3 Short stature, not elsewhere classified	0.000	0.957	0.043
E34.2 Ectopic hormone secretion, not elsewhere classified	0.000	0.957	0.043
E34.1 Other hypersecretion of intestinal hormones	0.000	0.957	0.043
E55.0 Rickets, active	0.000	0.957	0.043
E24.8 Other Cushing's syndrome	0.000	0.958	0.042
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.000	0.958	0.042
E24.3 Ectopic ACTH syndrome	0.000	0.958	0.042
E24.1 Nelson's syndrome	0.000	0.958	0.042
E34.8 Other specified endocrine disorders	0.000	0.958	0.042
E23.6 Other disorders of pituitary gland	0.000	0.958	0.041
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.000	0.959	0.041
E27.3 Drug-induced adrenocortical insufficiency	0.000	0.960	0.040
E61 Deficiency of other nutrient elements	0.001	0.960	0.039
E34.0 Carcinoid syndrome	0.000	0.961	0.039
E27.5 Adrenomedullary hyperfunction	0.000	0.961	0.038
E27.0 Other adrenocortical overactivity	0.000	0.961	0.038
E24.0 Pituitary-dependent Cushing's disease	0.000	0.962	0.038
E27.4 Other and unspecified adrenocortical insufficiency	0.000	0.962	0.037
E05.0 Thyrotoxicosis with diffuse goitre	0.000	0.968	0.032
E28.3 Primary ovarian failure	0.000	0.969	0.031
E27.2 Addisonian crisis	0.000	0.970	0.030
E24.9 Cushing's syndrome, unspecified	0.000	0.970	0.030
E21.3 Hyperparathyroidism, unspecified	0.000	0.970	0.030
E86 Volume depletion	0.000	0.970	0.030
E21.4 Other specified disorders of parathyroid gland	0.000	0.970	0.029
E21.2 Other hyperparathyroidism	0.000	0.970	0.029
E22 Hyperfunction of pituitary gland	0.000	0.971	0.028
E61.9 Deficiency of nutrient element, unspecified	0.001	0.971	0.028
E61.8 Deficiency of other specified nutrient elements	0.001	0.971	0.028
E61.7 Deficiency of multiple nutrient elements	0.001	0.971	0.028
E61.6 Vanadium deficiency	0.001	0.971	0.028
E61.5 Molybdenum deficiency	0.001	0.971	0.028
E61.4 Chromium deficiency	0.001	0.971	0.028
E61.3 Manganese deficiency	0.001	0.971	0.028
E61.0 Copper deficiency	0.001	0.971	0.028
E21.5 Disorder of parathyroid gland, unspecified	0.000	0.973	0.027
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.000	0.973	0.027
E55.9 Vitamin D deficiency, unspecified	0.000	0.973	0.027
E27.8 Other specified disorders of adrenal gland	0.000	0.975	0.025
E23.0 Hypopituitarism	0.000	0.976	0.024
E61.2 Magnesium deficiency	0.001	0.977	0.022
E27.9 Disorder of adrenal gland, unspecified	0.001	0.978	0.022
E22.9 Hyperfunction of pituitary gland, unspecified	0.000	0.979	0.021
E22.8 Other hyperfunction of pituitary gland	0.000	0.979	0.021
E66.9 Obesity, unspecified	0.000	0.980	0.020
K90-K93 Other diseases of the digestive system	0.000	0.980	0.020
E22.1 Hyperprolactinaemia	0.000	0.981	0.018
E21.0 Primary hyperparathyroidism	0.000	0.984	0.016
C71.2 Temporal lobe	0.016	0.984	0.000
C71 Malignant neoplasm of brain	0.015	0.985	0.000
E87.6 Hypokalaemia	0.000	0.985	0.015
C71.9 Brain, unspecified	0.015	0.985	0.000
K93 Disorders of other digestive organs in diseases classified elsewhere	0.000	0.985	0.014
E05.9 Thyrotoxicosis, unspecified	0.000	0.986	0.014
E22.0 Acromegaly and pituitary gigantism	0.001	0.986	0.013
C71.3 Parietal lobe	0.013	0.987	0.000
C71.1 Frontal lobe	0.013	0.987	0.000
C71.7 Brain stem	0.011	0.988	0.000
R31 Unspecified haematuria	0.011	0.989	0.000
C71.6 Cerebellum	0.011	0.989	0.000
C71.5 Cerebral ventricle	0.011	0.989	0.000
C71.0 Cerebrum, except lobes and ventricles	0.011	0.989	0.000
C71.8 Overlapping lesion of brain	0.011	0.989	0.000
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere	0.000	0.989	0.010
K93.1 Megacolon in Chagas' disease	0.000	0.989	0.010
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands	0.000	0.989	0.010
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.001	0.989	0.010
G31.8 Other specified degenerative diseases of nervous system	0.000	0.989	0.011
E61.1 Iron deficiency	0.001	0.990	0.009
M41.9 Scoliosis, unspecified	0.010	0.990	0.000
M41.96 Scoliosis, unspecified (Lumbar region)	0.010	0.990	0.000
G31 Other degenerative diseases of nervous system, not elsewhere classified	0.000	0.990	0.010
C71.4 Occipital lobe	0.009	0.991	0.000
M41.97 Scoliosis, unspecified (Lumbosacral region)	0.009	0.991	0.000
M41.94 Scoliosis, unspecified (Thoracic region)	0.009	0.991	0.000
M41.99 Scoliosis, unspecified (Site unspecified)	0.009	0.991	0.000
G31.9 Degenerative disease of nervous system, unspecified	0.000	0.991	0.009
G31.0 Circumscribed brain atrophy	0.000	0.991	0.009
E66.8 Other obesity	0.000	0.991	0.009
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.009	0.991	0.000
C69 Malignant neoplasm of eye and adnexa	0.008	0.992	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.008	0.992	0.000
M41.98 Scoliosis, unspecified (Sacral and sacrococcygeal region)	0.007	0.992	0.000
M41.93 Scoliosis, unspecified (Cervicothoracic region)	0.007	0.992	0.000
M41.92 Scoliosis, unspecified (Cervical region)	0.007	0.992	0.000
M41.91 Scoliosis, unspecified (Occipito-atlanto-axial region)	0.007	0.992	0.000
M41.95 Scoliosis, unspecified (Thoracolumbar region)	0.007	0.993	0.000
G31.1 Senile degeneration of brain, not elsewhere classified	0.000	0.993	0.007
C70 Malignant neoplasm of meninges	0.007	0.993	0.000
G44.2 Tension-type headache	0.007	0.993	0.000
C69.9 Eye, unspecified	0.007	0.993	0.000
M41.90 Scoliosis, unspecified (Multiple sites in spine)	0.006	0.993	0.000
C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system	0.006	0.994	0.000
C69.3 Choroid	0.006	0.994	0.000
K62.5 Haemorrhage of anus and rectum	0.006	0.994	0.000
C69.8 Overlapping lesion of eye and adnexa	0.006	0.994	0.000
C69.5 Lachrymal gland and duct	0.006	0.994	0.000
C69.4 Ciliary body	0.006	0.994	0.000
C69.2 Retina	0.006	0.994	0.000
C69.1 Cornea	0.006	0.994	0.000
C70.0 Cerebral meninges	0.006	0.994	0.000
N04.9 Unspecified	0.000	0.994	0.006
C69.6 Orbit	0.006	0.994	0.000
G31.2 Degeneration of nervous system due to alcohol	0.000	0.994	0.006
M79.10 Myalgia (Multiple sites)	0.006	0.994	0.000
C69.0 Conjunctiva	0.005	0.994	0.000
G30-G32 Other degenerative diseases of the nervous system	0.000	0.994	0.006
G54.9 Nerve root and plexus disorder, unspecified	0.005	0.995	0.000
C70.9 Meninges, unspecified	0.005	0.995	0.000
C70.1 Spinal meninges	0.005	0.995	0.000
G30 Alzheimer's disease	0.000	0.995	0.005
M41 Scoliosis	0.005	0.995	0.000
C72.9 Central nervous system, unspecified	0.005	0.995	0.000
C72.8 Overlapping lesion of brain and other parts of central nervous system	0.005	0.995	0.000
C72.5 Other and unspecified cranial nerves	0.005	0.995	0.000
C72.4 Acoustic nerve	0.005	0.995	0.000
C72.3 Optic nerve	0.005	0.995	0.000
C72.2 Olfactory nerve	0.005	0.995	0.000
C72.1 Cauda equina	0.005	0.995	0.000
E11.9 Without complications	0.000	0.995	0.005
R52.1 Chronic intractable pain	0.005	0.995	0.000
G30.0 Alzheimer's disease with early onset	0.000	0.995	0.005
C72.0 Spinal cord	0.004	0.995	0.000
E87.1 Hypo-osmolality and hyponatraemia	0.000	0.995	0.005
K22.6 Gastro-oesophageal laceration-haemorrhage syndrome	0.004	0.996	0.000
M67.8 Other specified disorders of synovium and tendon	0.000	0.996	0.004
G30.9 Alzheimer's disease, unspecified	0.000	0.996	0.004
M22.2 Patellofemoral disorders	0.004	0.996	0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere	0.000	0.996	0.004

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations